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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SF1-ZSWIM5 (FusionGDB2 ID:80449)

Fusion Gene Summary for SF1-ZSWIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: SF1-ZSWIM5
Fusion gene ID: 80449
HgeneTgene
Gene symbol

SF1

ZSWIM5

Gene ID

7536

57643

Gene namesplicing factor 1zinc finger SWIM-type containing 5
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162-
Cytomap

11q13.1

1p34.1

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162zinc finger SWIM domain-containing protein 5zinc finger, SWIM domain containing 5
Modification date2020031820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000227503, 
ENST00000334944, ENST00000422298, 
ENST00000433274, ENST00000489544, 
ENST00000359600, ENST00000464588, 
Fusion gene scores* DoF score21 X 11 X 13=30039 X 6 X 4=216
# samples 269
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SF1 [Title/Abstract] AND ZSWIM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSF1(64543970)-ZSWIM5(45553909), # samples:2
Anticipated loss of major functional domain due to fusion event.SF1-ZSWIM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZSWIM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EY-A3QX-01ASF1chr11

64543970

-ZSWIM5chr1

45553909

-
ChimerDB4UCECTCGA-EY-A3QX-01ASF1chr11

64543970

-ZSWIM5chr1

45553909

-


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Fusion Gene ORF analysis for SF1-ZSWIM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377387ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000377387ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
In-frameENST00000377390ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000377390ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
In-frameENST00000377394ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000377394ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
In-frameENST00000227503ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000227503ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
In-frameENST00000334944ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000334944ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5UTR-3CDSENST00000422298ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5UTR-5UTRENST00000422298ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
Frame-shiftENST00000433274ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
5CDS-5UTRENST00000433274ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-
intron-3CDSENST00000489544ENST00000359600SF1chr11

64543970

-ZSWIM5chr1

45553909

-
intron-5UTRENST00000489544ENST00000464588SF1chr11

64543970

-ZSWIM5chr1

45553909

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377387SF1chr1164543970-ENST00000359600ZSWIM5chr145553909-56306127735741165
ENST00000377390SF1chr1164543970-ENST00000359600ZSWIM5chr145553909-551649833834601040
ENST00000377394SF1chr1164543970-ENST00000359600ZSWIM5chr145553909-553351535534771040
ENST00000227503SF1chr1164543970-ENST00000359600ZSWIM5chr145553909-553351535534771040
ENST00000334944SF1chr1164543970-ENST00000359600ZSWIM5chr145553909-557255439435161040

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377387ENST00000359600SF1chr1164543970-ZSWIM5chr145553909-0.0022746650.9977253
ENST00000377390ENST00000359600SF1chr1164543970-ZSWIM5chr145553909-0.0022771110.9977229
ENST00000377394ENST00000359600SF1chr1164543970-ZSWIM5chr145553909-0.0022919970.99770796
ENST00000227503ENST00000359600SF1chr1164543970-ZSWIM5chr145553909-0.0022919970.99770796
ENST00000334944ENST00000359600SF1chr1164543970-ZSWIM5chr145553909-0.0024338460.9975662

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Fusion Genomic Features for SF1-ZSWIM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SF1-ZSWIM5


check button Go to

FGviewer for the breakpoints of chr11:64543970-chr1:45553909

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543970chr1:45553909ENST00000227503-21315_1953.333333333333336549.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr1:45553909ENST00000334944-21415_1953.333333333333336639.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr1:45553909ENST00000377387-21315_19178.33333333333334674.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr1:45553909ENST00000377390-21315_1953.333333333333336640.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr1:45553909ENST00000377394-21315_1953.333333333333336572.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr1:45553909ENST00000433274-21315_1927.333333333333332614.0MotifNuclear localization signal
TgeneZSWIM5chr11:64543970chr1:45553909ENST00000359600014219_256198.333333333333341186.0Zinc fingerSWIM-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543970chr1:45553909ENST00000227503-213324_63753.333333333333336549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000334944-214324_63753.333333333333336639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000377387-213324_637178.33333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000377390-213324_63753.333333333333336640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000377394-213324_63753.333333333333336572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000433274-213324_63727.333333333333332614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr1:45553909ENST00000227503-213141_22253.333333333333336549.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000334944-214141_22253.333333333333336639.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000377387-213141_222178.33333333333334674.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000377390-213141_22253.333333333333336640.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000377394-213141_22253.333333333333336572.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000433274-213141_22227.333333333333332614.0DomainKH
HgeneSF1chr11:64543970chr1:45553909ENST00000227503-213277_29653.333333333333336549.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr1:45553909ENST00000334944-214277_29653.333333333333336639.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr1:45553909ENST00000377387-213277_296178.33333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr1:45553909ENST00000377390-213277_29653.333333333333336640.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr1:45553909ENST00000377394-213277_29653.333333333333336572.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr1:45553909ENST00000433274-213277_29627.333333333333332614.0Zinc fingerCCHC-type


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Fusion Gene Sequence for SF1-ZSWIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000377387_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(transcript)=5630nt_BP=612nt
CCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAG
CGAACGCCACGCCGTTGGGTAAGCTGGGCCCCCCCGGGCTGCCCCCGCTCCCCGGGCCCAAAGGAGGCTTCGAGCCGGGCCCTCCGCCTG
CACCCGGGCCTGGGGCGGGGCTGCTGGCTCCCGGGCCGCCGCCGCCCCCGCCCGTGGGCTCGATGGGGGCCCTGACCGCGGCCTTCCCCT
TCGCGGCGCTGCCTCCGCCGCCTCCGCCGCCGCCCCCTCCGCCTCCCCAGCAGCCGCCGCCGCCTCCACCGCCACCGTCCCCCGGCGCCT
CGTACCCGCCGCCGCAGCCGCCCCCTCCGCCGCCGCTCTACCAGCGCGTGTCGCCGCCGCAGCCGCCGCCACCCCAGCCGCCGCGTAAGG
ACCAGCAGCCGGGCCCGGCCGGCGGCGGAGGAGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGA
AGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGGCTTTCATCTGAGTGGCA
CAGTAACTGAGCTGGCCACTGCCTCTGAACCAGCAGTGACTTATAAAGTTGCAATCAGTTTTGATCGATGCAAAATCACCTCAGTGACAT
GTGGCTGTGGGAACAAGGACATATTCTACTGTGCCCATGTGGTAGCACTCTCACTCTACAGGATCCGTAAACCAGACCAAGTCAAATTGC
GTCTTCCTATCTCCGAAACCCTTTTCCAGATGAATAGGGACCAGCTACAAAAGTTTATTCAATATTTAATCACGGCACACCACACTGAAG
TTCTTCCTACTGCACAGAAACTGGCAGATGAGATTCTATCCTCCAACTCAGAAATCAACCAAGTGAATGGTGCCCCTGACCCCACAGCTG
GGGCCAGCATTGACGATGAGAACTGTTGGCATTTGGATGAAGAACAGGTGAAAGAACAAGTGAAGCTTTTTCTCTCCCAGGGCGGTTACT
GTGGCTCTGGAAAGCAACTCAACTCAATGTTTGCCAAGGTTCGAGAAATGCTGCGGATGAGAGATTCCAATGGAGCAAGGATGCTGACAC
TAATAACTGAGCAGTTTGTGGCTGACCCACGACTCACACTCTGGAGGCAGCAAGGAACAAACATGACAGACAAGTGCAGGCAGCTCTGGG
ATGAGCTAGGGGCTTTATGGGTGTGCATAATTTTAAATCCACACTGCAAACTGGAGGAGAAATCCTGCTGGCTGCAGCAGCTGCAGAAGT
GGAGCGACCTGGATGTCTGTCCCCTGGAGGATGGAAACTATGGACATGAGCTGCCCAACATCACCAATGCACTTCCCCAGAGTGCCATTC
ACAGCCCAGACTCCTTATCCAGACCAAGACGAACAGTATTCACTAGAGCCATTGAGGGGCGTGAATTACATTGGCAGGATAGCCACCTAC
AGCGAATAATCAGCAGTGATGTTTATACAGCTCCTGCCTGCCAGCGGGAAAGTGAAAGACTACTCTTTAATTCCCAAGGCCAGCCACTGT
GGCTTGAGCATGTGCCTACAGCCTGTGCTCGAGTTGACGCCCTGCGTTCCCATGGTTATCCAAAAGAGGCCCTCAGACTCACAGTGGCCA
TTATTAATACTCTGAGGTTGCAGCAGCAGCGGCAACTGGAAATCTACAAGCATCAGAAGAAAGAACTGTTGCAGAGAGGAACCACAACCA
TCACAAACCTGGAGGGCTGGGTGGGCCACCCCCTGGATCCCATCGACTGCCTGTTTCTCACTTTGACTGAGGCCTGCCGCCTGAATGATG
ATGGCTATCTGGAGATGTCAGATATGAATGAAAGCAGACCCCCTGTGTACCAGCATGTACCTGTGGCTGCAGGCTCCCCAAACAGCAGTG
AGTCCTACCTGTCATTGGCCCTGGAAGTTGCACTGATGGGCCTGGGTCAACAGAGGTTAATGCCTGAAGGCCTCTACGCACAGGACAAGG
TATGCCGTAATGAGGAGCAGCTCCTGAGCCAACTCCAAGAGCTGCAGCTGGACGATGAGCTAGTGCAAACACTGCAAAAACAATGCATCT
TACTGCTGGAAGGAGGTCCTTTCAGCGGTCTGGGAGAAGTCATCCACCGAGAGAGTGTTCCCATGCATACCTTTGCCAAGTATTTGTTCT
CAGCTCTGCTGCCTCATGATCCAGACCTGTCCTATAAATTAGCCTTACGTGCCATGAGGTTACCTGTTTTAGAAAACTCAGCTTCTGCAG
GCGACACATCCCACCCTCACCATATGGTGTCTGTGGTGCCCAGCCGTTATCCTCGCTGGTTCACGCTTGGACACTTGGAATCACAGCAGT
GTGAACTGGCCTCCACCATGCTGACTGCTGCCAAAGGAGACACTTTGAGACTCCGAACAATTCTGGAAGCAATACAGAAGCACATTCATT
CTTCCTCCCTCATCTTCAAACTGGCCCAAGATGCATTCAAGATTGCTACTCCCACCGACAGTAGTACTGACAGCACCCTGCTCAACGTTG
CCCTGGAACTTGGGTTACAGGTGATGCGGATGACCTTATCAACCCTTAACTGGAGACGCAGGGAGATGGTACGATGGTTGGTGACCTGTG
CTACAGAAGTGGGTGTGCGGGCCCTGGTGAGCATCTTGCAGAGCTGGTACACACTCTTCACCCCTACTGAGGCTACTAGTATTGTAGCTG
CCACAGCCGTATCCCACACCACTATCCTGCGCCTCAGTCTTGACTATCCACAGCGGGAGGAACTGGCTAGCTGTGCTCGCACACTGGCTC
TACAGTGTGCTATGAAGGATCCACAGAGCTGTGCCCTGTCAGCCCTTACACTCTGTGAGAAAGACCACATTGCCTTTGAGGCAGCCTACC
AGATTGCCATTGATGCTGCTGCTGGTGGTATGACCCATTCACAGCTGTTCACCATCGCCCGCTACATGGAGCTCCGTGGCTACCCGCTAC
GTGCCTTCAAGCTGGCCTCATTGGCCATGAGCCATCTTAACCTGGCCTACAACCAGGATACTCACCCAGCCATCAATGATGTGCTCTGGG
CTTGTGCTCTCAGCCACTCTCTGGGCAAGAATGAGCTGGCAGCTCTCATCCCCCTGGTGGTGAAGAGTGTGCACTGTGCCACAGTGCTTT
CAGACATCTTACGACGCTGCACAGTGACTGCACCTGGCCTGGCCGGCATCCCAGGCCGCCGAAGCTCTGGAAAGCTCATGTCCACTGACA
AAGCTCCATTGCGCCAGTTGCTGGATGCCACCATCAATGCCTATATCAACACTACACACTCACGCCTAACACACATCAGCCCTCGCCACT
ATGGAGAGTTCATTGAGTTTCTAAGCAAGGCTCGGGAGACCTTCCTGCTGCCCCAGGATGGCCACCTGCAGTTTGCCCAGTTCATCGACA
ACCTCAAACAGATCTACAAAGGCAAGAAAAAGTTGATGCTGCTGGTGCGAGAGCGCTTTGGCTGAGAGAGCAGATAGCTCACTGCCAGAG
CAGCCTGGGTTCCCAGGTAGTATCAGGTCAGGCCAAGGGCACTGAAACATTTGTCCACCCTGAGAGAACTCTGAGCACCTGTGGATGAGG
CCAAAGGACCACAGGGCTAAGGATGGGGAAAGTCCAGCTCTAGTCGATAATGCCTACCTTGGCAAGCTTCTGACTACAGCCTACTGTTCA
TGGAGGAGCTGGGCCCTGCAGATCGACCAGAAACCCCACAACATGCCACCTCATGCCCCTATATCCTGCGTGTCCTGAGCATTGGCCCTG
TCTCCCTTGGCAAACACAGAACACTGTTCCATCTCAGGGATTGCTTAACCAGAGAAACAGACACATTTGTGGGACTGTAAATACTATATG
TGTTGCTAATTATTGTAAACTTGTAACTATTTATAATTCTGCTTCTGATTTGATGGGCACTTGAAGTAGCTGTGGGTAGGAGGATATGCT
TATTTTCTGAGGAGACTCACAACCATTTCTCAGGTTTCCCTTGCAGAGTGTTTGCTGGTAGCAGTGGAAGAGTGGGGGTGCCAAGGAGAA
AAATGGCCAGTTAGGATCAACCCAAGTCTAGTCTATGCAGAATCCCCCACCTACAGACAGGGCATTTATAGTCCAGTGGTGAGTGAGGGA
CAGAGGCCAGGACTGGACTTAGACTTTTGCCTCACAAAACTGTGAGGACATTGAAGCTCCTGCCTCACACAGCCTCTTCAGGAGCCTGCT
GAACACCTGAGAAACAAGTGCAGGGAGAAGATGAAGGTCTGGGAAGCCGCTGAGTTCATAATATTCATCTACTGTGGTCACCTTTGTGTT
AGCAAGTGTGTGGTTTCATCTATAATTGTGTGTGTGTATCTTTATGGCTAAGTACATGTGTGTATGTACATAGATACATCTGTGCATGCC
TGTTTGTGCACATATATATTTATGTGTATGTGTCAGTTCTATGGCTGTGTACCTGTTTGAATATGTGCACACTGGACTGTGAGTTTCTAC
GTGAGGATATACACATTTTGTGTACATGTGAGGATGCACATCTTTGTGCAAATGCACTCATGTTTGTGCATGTTTAGTATGTGTATCTGC
GTACACGAGTGCATGTGTATAAACATGTTTGTATCCATGTGTATGCTTGTTATCCATGCATCTGTGTCTTTATATGTGTAACTGAGCGTA
TTTCTACATGTAGGGATGTCTGTGTATTCATGTTTGAGGATCTGCATCAATGTGTCCTTTTTGCCAGATTTCTCTTTCCCATTCCTCTTA
AATCTCTCTCGCCAGCTAAACGTTTGTTCCCCATCTCTGTGCCTCCTCTATTCATTCTCTCACCAAACAAGCTTCTAAGCACCAATCTCC
CTCTGCCATCAGATTGGCTGCTTTAGCTCCATAGTTCTCTTCTCGCCTCATACTTGCTTTCTTCCCCTGCCTTTCTACCTCAAGCTTCCT
CGCCGGCTTTTGTCACAGTCTCATTGCTCGCTGACTTGGAGGCTAGGGCTGGTCTGCACTTAGCCTCTCCCTTCCTAATTTCTAGCCCTA
GTGGGCAGTCCTGTCTTAGCCCTGGCTGACCTCCATAGTGTATCATGTTCCTGCTACCTTCCTGACCCCTGTGCTCAGCCTGGAATTGTT
ATAGGAGGTAGCAAGGGCACTCAGAAAAGTCAGTTGGAACCAGTGTCTTGGTGTTTACTGTTTCATGTCTTAGTTCCTGAGTTGGGGGTG
GGGTTTGATAGGGAAGGGGTGGTATAGCTAGAATGTGAACTAAGAACTTCTCCATCTGCTTTACTTTTTCTTTCTTCGACAAACTGTCAC
CTTTTTTACTCCAAACTGACCAAGAAGTTGTATTTGCCATTTGTGGCTACTCAAGTCTTACTGTCCAGCCAAGGGCCCCTACGTCTCAGC
CCAATGGGTTGGTTAAAAAAAAGAGAGAAGCCACTCTCATTTCTGTATCACAGTTGCCCTTTTTTAGCAAGTGTGTGAATTCACAGTGCT

>In-frame_ENST00000377387_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(amino acids)=1165AA_start in transcript=77_stop in transcript=3574
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGF
HLSGTVTELATASEPAVTYKVAISFDRCKITSVTCGCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITA
HHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAGASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGA
RMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWDELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALP
QSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQRIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALR
LTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTITNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGS
PNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKVCRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFA
KYLFSALLPHDPDLSYKLALRAMRLPVLENSASAGDTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQ
KHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVALELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEAT
SIVAATAVSHTTILRLSLDYPQREELASCARTLALQCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELR
GYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWACALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKL

--------------------------------------------------------------
>In-frame_ENST00000377390_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(transcript)=5516nt_BP=498nt
ACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAG
GCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCT
CCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCC
GGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCA
CGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTA
CAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGGCTTTCATCTGAGTGGCACAGTAACTGAGCTGGCCACTGCCT
CTGAACCAGCAGTGACTTATAAAGTTGCAATCAGTTTTGATCGATGCAAAATCACCTCAGTGACATGTGGCTGTGGGAACAAGGACATAT
TCTACTGTGCCCATGTGGTAGCACTCTCACTCTACAGGATCCGTAAACCAGACCAAGTCAAATTGCGTCTTCCTATCTCCGAAACCCTTT
TCCAGATGAATAGGGACCAGCTACAAAAGTTTATTCAATATTTAATCACGGCACACCACACTGAAGTTCTTCCTACTGCACAGAAACTGG
CAGATGAGATTCTATCCTCCAACTCAGAAATCAACCAAGTGAATGGTGCCCCTGACCCCACAGCTGGGGCCAGCATTGACGATGAGAACT
GTTGGCATTTGGATGAAGAACAGGTGAAAGAACAAGTGAAGCTTTTTCTCTCCCAGGGCGGTTACTGTGGCTCTGGAAAGCAACTCAACT
CAATGTTTGCCAAGGTTCGAGAAATGCTGCGGATGAGAGATTCCAATGGAGCAAGGATGCTGACACTAATAACTGAGCAGTTTGTGGCTG
ACCCACGACTCACACTCTGGAGGCAGCAAGGAACAAACATGACAGACAAGTGCAGGCAGCTCTGGGATGAGCTAGGGGCTTTATGGGTGT
GCATAATTTTAAATCCACACTGCAAACTGGAGGAGAAATCCTGCTGGCTGCAGCAGCTGCAGAAGTGGAGCGACCTGGATGTCTGTCCCC
TGGAGGATGGAAACTATGGACATGAGCTGCCCAACATCACCAATGCACTTCCCCAGAGTGCCATTCACAGCCCAGACTCCTTATCCAGAC
CAAGACGAACAGTATTCACTAGAGCCATTGAGGGGCGTGAATTACATTGGCAGGATAGCCACCTACAGCGAATAATCAGCAGTGATGTTT
ATACAGCTCCTGCCTGCCAGCGGGAAAGTGAAAGACTACTCTTTAATTCCCAAGGCCAGCCACTGTGGCTTGAGCATGTGCCTACAGCCT
GTGCTCGAGTTGACGCCCTGCGTTCCCATGGTTATCCAAAAGAGGCCCTCAGACTCACAGTGGCCATTATTAATACTCTGAGGTTGCAGC
AGCAGCGGCAACTGGAAATCTACAAGCATCAGAAGAAAGAACTGTTGCAGAGAGGAACCACAACCATCACAAACCTGGAGGGCTGGGTGG
GCCACCCCCTGGATCCCATCGACTGCCTGTTTCTCACTTTGACTGAGGCCTGCCGCCTGAATGATGATGGCTATCTGGAGATGTCAGATA
TGAATGAAAGCAGACCCCCTGTGTACCAGCATGTACCTGTGGCTGCAGGCTCCCCAAACAGCAGTGAGTCCTACCTGTCATTGGCCCTGG
AAGTTGCACTGATGGGCCTGGGTCAACAGAGGTTAATGCCTGAAGGCCTCTACGCACAGGACAAGGTATGCCGTAATGAGGAGCAGCTCC
TGAGCCAACTCCAAGAGCTGCAGCTGGACGATGAGCTAGTGCAAACACTGCAAAAACAATGCATCTTACTGCTGGAAGGAGGTCCTTTCA
GCGGTCTGGGAGAAGTCATCCACCGAGAGAGTGTTCCCATGCATACCTTTGCCAAGTATTTGTTCTCAGCTCTGCTGCCTCATGATCCAG
ACCTGTCCTATAAATTAGCCTTACGTGCCATGAGGTTACCTGTTTTAGAAAACTCAGCTTCTGCAGGCGACACATCCCACCCTCACCATA
TGGTGTCTGTGGTGCCCAGCCGTTATCCTCGCTGGTTCACGCTTGGACACTTGGAATCACAGCAGTGTGAACTGGCCTCCACCATGCTGA
CTGCTGCCAAAGGAGACACTTTGAGACTCCGAACAATTCTGGAAGCAATACAGAAGCACATTCATTCTTCCTCCCTCATCTTCAAACTGG
CCCAAGATGCATTCAAGATTGCTACTCCCACCGACAGTAGTACTGACAGCACCCTGCTCAACGTTGCCCTGGAACTTGGGTTACAGGTGA
TGCGGATGACCTTATCAACCCTTAACTGGAGACGCAGGGAGATGGTACGATGGTTGGTGACCTGTGCTACAGAAGTGGGTGTGCGGGCCC
TGGTGAGCATCTTGCAGAGCTGGTACACACTCTTCACCCCTACTGAGGCTACTAGTATTGTAGCTGCCACAGCCGTATCCCACACCACTA
TCCTGCGCCTCAGTCTTGACTATCCACAGCGGGAGGAACTGGCTAGCTGTGCTCGCACACTGGCTCTACAGTGTGCTATGAAGGATCCAC
AGAGCTGTGCCCTGTCAGCCCTTACACTCTGTGAGAAAGACCACATTGCCTTTGAGGCAGCCTACCAGATTGCCATTGATGCTGCTGCTG
GTGGTATGACCCATTCACAGCTGTTCACCATCGCCCGCTACATGGAGCTCCGTGGCTACCCGCTACGTGCCTTCAAGCTGGCCTCATTGG
CCATGAGCCATCTTAACCTGGCCTACAACCAGGATACTCACCCAGCCATCAATGATGTGCTCTGGGCTTGTGCTCTCAGCCACTCTCTGG
GCAAGAATGAGCTGGCAGCTCTCATCCCCCTGGTGGTGAAGAGTGTGCACTGTGCCACAGTGCTTTCAGACATCTTACGACGCTGCACAG
TGACTGCACCTGGCCTGGCCGGCATCCCAGGCCGCCGAAGCTCTGGAAAGCTCATGTCCACTGACAAAGCTCCATTGCGCCAGTTGCTGG
ATGCCACCATCAATGCCTATATCAACACTACACACTCACGCCTAACACACATCAGCCCTCGCCACTATGGAGAGTTCATTGAGTTTCTAA
GCAAGGCTCGGGAGACCTTCCTGCTGCCCCAGGATGGCCACCTGCAGTTTGCCCAGTTCATCGACAACCTCAAACAGATCTACAAAGGCA
AGAAAAAGTTGATGCTGCTGGTGCGAGAGCGCTTTGGCTGAGAGAGCAGATAGCTCACTGCCAGAGCAGCCTGGGTTCCCAGGTAGTATC
AGGTCAGGCCAAGGGCACTGAAACATTTGTCCACCCTGAGAGAACTCTGAGCACCTGTGGATGAGGCCAAAGGACCACAGGGCTAAGGAT
GGGGAAAGTCCAGCTCTAGTCGATAATGCCTACCTTGGCAAGCTTCTGACTACAGCCTACTGTTCATGGAGGAGCTGGGCCCTGCAGATC
GACCAGAAACCCCACAACATGCCACCTCATGCCCCTATATCCTGCGTGTCCTGAGCATTGGCCCTGTCTCCCTTGGCAAACACAGAACAC
TGTTCCATCTCAGGGATTGCTTAACCAGAGAAACAGACACATTTGTGGGACTGTAAATACTATATGTGTTGCTAATTATTGTAAACTTGT
AACTATTTATAATTCTGCTTCTGATTTGATGGGCACTTGAAGTAGCTGTGGGTAGGAGGATATGCTTATTTTCTGAGGAGACTCACAACC
ATTTCTCAGGTTTCCCTTGCAGAGTGTTTGCTGGTAGCAGTGGAAGAGTGGGGGTGCCAAGGAGAAAAATGGCCAGTTAGGATCAACCCA
AGTCTAGTCTATGCAGAATCCCCCACCTACAGACAGGGCATTTATAGTCCAGTGGTGAGTGAGGGACAGAGGCCAGGACTGGACTTAGAC
TTTTGCCTCACAAAACTGTGAGGACATTGAAGCTCCTGCCTCACACAGCCTCTTCAGGAGCCTGCTGAACACCTGAGAAACAAGTGCAGG
GAGAAGATGAAGGTCTGGGAAGCCGCTGAGTTCATAATATTCATCTACTGTGGTCACCTTTGTGTTAGCAAGTGTGTGGTTTCATCTATA
ATTGTGTGTGTGTATCTTTATGGCTAAGTACATGTGTGTATGTACATAGATACATCTGTGCATGCCTGTTTGTGCACATATATATTTATG
TGTATGTGTCAGTTCTATGGCTGTGTACCTGTTTGAATATGTGCACACTGGACTGTGAGTTTCTACGTGAGGATATACACATTTTGTGTA
CATGTGAGGATGCACATCTTTGTGCAAATGCACTCATGTTTGTGCATGTTTAGTATGTGTATCTGCGTACACGAGTGCATGTGTATAAAC
ATGTTTGTATCCATGTGTATGCTTGTTATCCATGCATCTGTGTCTTTATATGTGTAACTGAGCGTATTTCTACATGTAGGGATGTCTGTG
TATTCATGTTTGAGGATCTGCATCAATGTGTCCTTTTTGCCAGATTTCTCTTTCCCATTCCTCTTAAATCTCTCTCGCCAGCTAAACGTT
TGTTCCCCATCTCTGTGCCTCCTCTATTCATTCTCTCACCAAACAAGCTTCTAAGCACCAATCTCCCTCTGCCATCAGATTGGCTGCTTT
AGCTCCATAGTTCTCTTCTCGCCTCATACTTGCTTTCTTCCCCTGCCTTTCTACCTCAAGCTTCCTCGCCGGCTTTTGTCACAGTCTCAT
TGCTCGCTGACTTGGAGGCTAGGGCTGGTCTGCACTTAGCCTCTCCCTTCCTAATTTCTAGCCCTAGTGGGCAGTCCTGTCTTAGCCCTG
GCTGACCTCCATAGTGTATCATGTTCCTGCTACCTTCCTGACCCCTGTGCTCAGCCTGGAATTGTTATAGGAGGTAGCAAGGGCACTCAG
AAAAGTCAGTTGGAACCAGTGTCTTGGTGTTTACTGTTTCATGTCTTAGTTCCTGAGTTGGGGGTGGGGTTTGATAGGGAAGGGGTGGTA
TAGCTAGAATGTGAACTAAGAACTTCTCCATCTGCTTTACTTTTTCTTTCTTCGACAAACTGTCACCTTTTTTACTCCAAACTGACCAAG
AAGTTGTATTTGCCATTTGTGGCTACTCAAGTCTTACTGTCCAGCCAAGGGCCCCTACGTCTCAGCCCAATGGGTTGGTTAAAAAAAAGA
GAGAAGCCACTCTCATTTCTGTATCACAGTTGCCCTTTTTTAGCAAGTGTGTGAATTCACAGTGCTTTTCTATGAATAAATCATGGATCA

>In-frame_ENST00000377390_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(amino acids)=1040AA_start in transcript=338_stop in transcript=3460
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTC
GCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAG
ASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWD
ELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALPQSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQ
RIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTI
TNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKV
CRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSASAG
DTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVA
LELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLAL
QCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWA
CALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHY

--------------------------------------------------------------
>In-frame_ENST00000377394_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(transcript)=5533nt_BP=515nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGT
GATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGGCTTTCATCTGAGTGGCACAGTAAC
TGAGCTGGCCACTGCCTCTGAACCAGCAGTGACTTATAAAGTTGCAATCAGTTTTGATCGATGCAAAATCACCTCAGTGACATGTGGCTG
TGGGAACAAGGACATATTCTACTGTGCCCATGTGGTAGCACTCTCACTCTACAGGATCCGTAAACCAGACCAAGTCAAATTGCGTCTTCC
TATCTCCGAAACCCTTTTCCAGATGAATAGGGACCAGCTACAAAAGTTTATTCAATATTTAATCACGGCACACCACACTGAAGTTCTTCC
TACTGCACAGAAACTGGCAGATGAGATTCTATCCTCCAACTCAGAAATCAACCAAGTGAATGGTGCCCCTGACCCCACAGCTGGGGCCAG
CATTGACGATGAGAACTGTTGGCATTTGGATGAAGAACAGGTGAAAGAACAAGTGAAGCTTTTTCTCTCCCAGGGCGGTTACTGTGGCTC
TGGAAAGCAACTCAACTCAATGTTTGCCAAGGTTCGAGAAATGCTGCGGATGAGAGATTCCAATGGAGCAAGGATGCTGACACTAATAAC
TGAGCAGTTTGTGGCTGACCCACGACTCACACTCTGGAGGCAGCAAGGAACAAACATGACAGACAAGTGCAGGCAGCTCTGGGATGAGCT
AGGGGCTTTATGGGTGTGCATAATTTTAAATCCACACTGCAAACTGGAGGAGAAATCCTGCTGGCTGCAGCAGCTGCAGAAGTGGAGCGA
CCTGGATGTCTGTCCCCTGGAGGATGGAAACTATGGACATGAGCTGCCCAACATCACCAATGCACTTCCCCAGAGTGCCATTCACAGCCC
AGACTCCTTATCCAGACCAAGACGAACAGTATTCACTAGAGCCATTGAGGGGCGTGAATTACATTGGCAGGATAGCCACCTACAGCGAAT
AATCAGCAGTGATGTTTATACAGCTCCTGCCTGCCAGCGGGAAAGTGAAAGACTACTCTTTAATTCCCAAGGCCAGCCACTGTGGCTTGA
GCATGTGCCTACAGCCTGTGCTCGAGTTGACGCCCTGCGTTCCCATGGTTATCCAAAAGAGGCCCTCAGACTCACAGTGGCCATTATTAA
TACTCTGAGGTTGCAGCAGCAGCGGCAACTGGAAATCTACAAGCATCAGAAGAAAGAACTGTTGCAGAGAGGAACCACAACCATCACAAA
CCTGGAGGGCTGGGTGGGCCACCCCCTGGATCCCATCGACTGCCTGTTTCTCACTTTGACTGAGGCCTGCCGCCTGAATGATGATGGCTA
TCTGGAGATGTCAGATATGAATGAAAGCAGACCCCCTGTGTACCAGCATGTACCTGTGGCTGCAGGCTCCCCAAACAGCAGTGAGTCCTA
CCTGTCATTGGCCCTGGAAGTTGCACTGATGGGCCTGGGTCAACAGAGGTTAATGCCTGAAGGCCTCTACGCACAGGACAAGGTATGCCG
TAATGAGGAGCAGCTCCTGAGCCAACTCCAAGAGCTGCAGCTGGACGATGAGCTAGTGCAAACACTGCAAAAACAATGCATCTTACTGCT
GGAAGGAGGTCCTTTCAGCGGTCTGGGAGAAGTCATCCACCGAGAGAGTGTTCCCATGCATACCTTTGCCAAGTATTTGTTCTCAGCTCT
GCTGCCTCATGATCCAGACCTGTCCTATAAATTAGCCTTACGTGCCATGAGGTTACCTGTTTTAGAAAACTCAGCTTCTGCAGGCGACAC
ATCCCACCCTCACCATATGGTGTCTGTGGTGCCCAGCCGTTATCCTCGCTGGTTCACGCTTGGACACTTGGAATCACAGCAGTGTGAACT
GGCCTCCACCATGCTGACTGCTGCCAAAGGAGACACTTTGAGACTCCGAACAATTCTGGAAGCAATACAGAAGCACATTCATTCTTCCTC
CCTCATCTTCAAACTGGCCCAAGATGCATTCAAGATTGCTACTCCCACCGACAGTAGTACTGACAGCACCCTGCTCAACGTTGCCCTGGA
ACTTGGGTTACAGGTGATGCGGATGACCTTATCAACCCTTAACTGGAGACGCAGGGAGATGGTACGATGGTTGGTGACCTGTGCTACAGA
AGTGGGTGTGCGGGCCCTGGTGAGCATCTTGCAGAGCTGGTACACACTCTTCACCCCTACTGAGGCTACTAGTATTGTAGCTGCCACAGC
CGTATCCCACACCACTATCCTGCGCCTCAGTCTTGACTATCCACAGCGGGAGGAACTGGCTAGCTGTGCTCGCACACTGGCTCTACAGTG
TGCTATGAAGGATCCACAGAGCTGTGCCCTGTCAGCCCTTACACTCTGTGAGAAAGACCACATTGCCTTTGAGGCAGCCTACCAGATTGC
CATTGATGCTGCTGCTGGTGGTATGACCCATTCACAGCTGTTCACCATCGCCCGCTACATGGAGCTCCGTGGCTACCCGCTACGTGCCTT
CAAGCTGGCCTCATTGGCCATGAGCCATCTTAACCTGGCCTACAACCAGGATACTCACCCAGCCATCAATGATGTGCTCTGGGCTTGTGC
TCTCAGCCACTCTCTGGGCAAGAATGAGCTGGCAGCTCTCATCCCCCTGGTGGTGAAGAGTGTGCACTGTGCCACAGTGCTTTCAGACAT
CTTACGACGCTGCACAGTGACTGCACCTGGCCTGGCCGGCATCCCAGGCCGCCGAAGCTCTGGAAAGCTCATGTCCACTGACAAAGCTCC
ATTGCGCCAGTTGCTGGATGCCACCATCAATGCCTATATCAACACTACACACTCACGCCTAACACACATCAGCCCTCGCCACTATGGAGA
GTTCATTGAGTTTCTAAGCAAGGCTCGGGAGACCTTCCTGCTGCCCCAGGATGGCCACCTGCAGTTTGCCCAGTTCATCGACAACCTCAA
ACAGATCTACAAAGGCAAGAAAAAGTTGATGCTGCTGGTGCGAGAGCGCTTTGGCTGAGAGAGCAGATAGCTCACTGCCAGAGCAGCCTG
GGTTCCCAGGTAGTATCAGGTCAGGCCAAGGGCACTGAAACATTTGTCCACCCTGAGAGAACTCTGAGCACCTGTGGATGAGGCCAAAGG
ACCACAGGGCTAAGGATGGGGAAAGTCCAGCTCTAGTCGATAATGCCTACCTTGGCAAGCTTCTGACTACAGCCTACTGTTCATGGAGGA
GCTGGGCCCTGCAGATCGACCAGAAACCCCACAACATGCCACCTCATGCCCCTATATCCTGCGTGTCCTGAGCATTGGCCCTGTCTCCCT
TGGCAAACACAGAACACTGTTCCATCTCAGGGATTGCTTAACCAGAGAAACAGACACATTTGTGGGACTGTAAATACTATATGTGTTGCT
AATTATTGTAAACTTGTAACTATTTATAATTCTGCTTCTGATTTGATGGGCACTTGAAGTAGCTGTGGGTAGGAGGATATGCTTATTTTC
TGAGGAGACTCACAACCATTTCTCAGGTTTCCCTTGCAGAGTGTTTGCTGGTAGCAGTGGAAGAGTGGGGGTGCCAAGGAGAAAAATGGC
CAGTTAGGATCAACCCAAGTCTAGTCTATGCAGAATCCCCCACCTACAGACAGGGCATTTATAGTCCAGTGGTGAGTGAGGGACAGAGGC
CAGGACTGGACTTAGACTTTTGCCTCACAAAACTGTGAGGACATTGAAGCTCCTGCCTCACACAGCCTCTTCAGGAGCCTGCTGAACACC
TGAGAAACAAGTGCAGGGAGAAGATGAAGGTCTGGGAAGCCGCTGAGTTCATAATATTCATCTACTGTGGTCACCTTTGTGTTAGCAAGT
GTGTGGTTTCATCTATAATTGTGTGTGTGTATCTTTATGGCTAAGTACATGTGTGTATGTACATAGATACATCTGTGCATGCCTGTTTGT
GCACATATATATTTATGTGTATGTGTCAGTTCTATGGCTGTGTACCTGTTTGAATATGTGCACACTGGACTGTGAGTTTCTACGTGAGGA
TATACACATTTTGTGTACATGTGAGGATGCACATCTTTGTGCAAATGCACTCATGTTTGTGCATGTTTAGTATGTGTATCTGCGTACACG
AGTGCATGTGTATAAACATGTTTGTATCCATGTGTATGCTTGTTATCCATGCATCTGTGTCTTTATATGTGTAACTGAGCGTATTTCTAC
ATGTAGGGATGTCTGTGTATTCATGTTTGAGGATCTGCATCAATGTGTCCTTTTTGCCAGATTTCTCTTTCCCATTCCTCTTAAATCTCT
CTCGCCAGCTAAACGTTTGTTCCCCATCTCTGTGCCTCCTCTATTCATTCTCTCACCAAACAAGCTTCTAAGCACCAATCTCCCTCTGCC
ATCAGATTGGCTGCTTTAGCTCCATAGTTCTCTTCTCGCCTCATACTTGCTTTCTTCCCCTGCCTTTCTACCTCAAGCTTCCTCGCCGGC
TTTTGTCACAGTCTCATTGCTCGCTGACTTGGAGGCTAGGGCTGGTCTGCACTTAGCCTCTCCCTTCCTAATTTCTAGCCCTAGTGGGCA
GTCCTGTCTTAGCCCTGGCTGACCTCCATAGTGTATCATGTTCCTGCTACCTTCCTGACCCCTGTGCTCAGCCTGGAATTGTTATAGGAG
GTAGCAAGGGCACTCAGAAAAGTCAGTTGGAACCAGTGTCTTGGTGTTTACTGTTTCATGTCTTAGTTCCTGAGTTGGGGGTGGGGTTTG
ATAGGGAAGGGGTGGTATAGCTAGAATGTGAACTAAGAACTTCTCCATCTGCTTTACTTTTTCTTTCTTCGACAAACTGTCACCTTTTTT
ACTCCAAACTGACCAAGAAGTTGTATTTGCCATTTGTGGCTACTCAAGTCTTACTGTCCAGCCAAGGGCCCCTACGTCTCAGCCCAATGG
GTTGGTTAAAAAAAAGAGAGAAGCCACTCTCATTTCTGTATCACAGTTGCCCTTTTTTAGCAAGTGTGTGAATTCACAGTGCTTTTCTAT

>In-frame_ENST00000377394_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(amino acids)=1040AA_start in transcript=355_stop in transcript=3477
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTC
GCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAG
ASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWD
ELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALPQSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQ
RIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTI
TNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKV
CRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSASAG
DTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVA
LELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLAL
QCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWA
CALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHY

--------------------------------------------------------------
>In-frame_ENST00000227503_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(transcript)=5533nt_BP=515nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGT
GATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGGCTTTCATCTGAGTGGCACAGTAAC
TGAGCTGGCCACTGCCTCTGAACCAGCAGTGACTTATAAAGTTGCAATCAGTTTTGATCGATGCAAAATCACCTCAGTGACATGTGGCTG
TGGGAACAAGGACATATTCTACTGTGCCCATGTGGTAGCACTCTCACTCTACAGGATCCGTAAACCAGACCAAGTCAAATTGCGTCTTCC
TATCTCCGAAACCCTTTTCCAGATGAATAGGGACCAGCTACAAAAGTTTATTCAATATTTAATCACGGCACACCACACTGAAGTTCTTCC
TACTGCACAGAAACTGGCAGATGAGATTCTATCCTCCAACTCAGAAATCAACCAAGTGAATGGTGCCCCTGACCCCACAGCTGGGGCCAG
CATTGACGATGAGAACTGTTGGCATTTGGATGAAGAACAGGTGAAAGAACAAGTGAAGCTTTTTCTCTCCCAGGGCGGTTACTGTGGCTC
TGGAAAGCAACTCAACTCAATGTTTGCCAAGGTTCGAGAAATGCTGCGGATGAGAGATTCCAATGGAGCAAGGATGCTGACACTAATAAC
TGAGCAGTTTGTGGCTGACCCACGACTCACACTCTGGAGGCAGCAAGGAACAAACATGACAGACAAGTGCAGGCAGCTCTGGGATGAGCT
AGGGGCTTTATGGGTGTGCATAATTTTAAATCCACACTGCAAACTGGAGGAGAAATCCTGCTGGCTGCAGCAGCTGCAGAAGTGGAGCGA
CCTGGATGTCTGTCCCCTGGAGGATGGAAACTATGGACATGAGCTGCCCAACATCACCAATGCACTTCCCCAGAGTGCCATTCACAGCCC
AGACTCCTTATCCAGACCAAGACGAACAGTATTCACTAGAGCCATTGAGGGGCGTGAATTACATTGGCAGGATAGCCACCTACAGCGAAT
AATCAGCAGTGATGTTTATACAGCTCCTGCCTGCCAGCGGGAAAGTGAAAGACTACTCTTTAATTCCCAAGGCCAGCCACTGTGGCTTGA
GCATGTGCCTACAGCCTGTGCTCGAGTTGACGCCCTGCGTTCCCATGGTTATCCAAAAGAGGCCCTCAGACTCACAGTGGCCATTATTAA
TACTCTGAGGTTGCAGCAGCAGCGGCAACTGGAAATCTACAAGCATCAGAAGAAAGAACTGTTGCAGAGAGGAACCACAACCATCACAAA
CCTGGAGGGCTGGGTGGGCCACCCCCTGGATCCCATCGACTGCCTGTTTCTCACTTTGACTGAGGCCTGCCGCCTGAATGATGATGGCTA
TCTGGAGATGTCAGATATGAATGAAAGCAGACCCCCTGTGTACCAGCATGTACCTGTGGCTGCAGGCTCCCCAAACAGCAGTGAGTCCTA
CCTGTCATTGGCCCTGGAAGTTGCACTGATGGGCCTGGGTCAACAGAGGTTAATGCCTGAAGGCCTCTACGCACAGGACAAGGTATGCCG
TAATGAGGAGCAGCTCCTGAGCCAACTCCAAGAGCTGCAGCTGGACGATGAGCTAGTGCAAACACTGCAAAAACAATGCATCTTACTGCT
GGAAGGAGGTCCTTTCAGCGGTCTGGGAGAAGTCATCCACCGAGAGAGTGTTCCCATGCATACCTTTGCCAAGTATTTGTTCTCAGCTCT
GCTGCCTCATGATCCAGACCTGTCCTATAAATTAGCCTTACGTGCCATGAGGTTACCTGTTTTAGAAAACTCAGCTTCTGCAGGCGACAC
ATCCCACCCTCACCATATGGTGTCTGTGGTGCCCAGCCGTTATCCTCGCTGGTTCACGCTTGGACACTTGGAATCACAGCAGTGTGAACT
GGCCTCCACCATGCTGACTGCTGCCAAAGGAGACACTTTGAGACTCCGAACAATTCTGGAAGCAATACAGAAGCACATTCATTCTTCCTC
CCTCATCTTCAAACTGGCCCAAGATGCATTCAAGATTGCTACTCCCACCGACAGTAGTACTGACAGCACCCTGCTCAACGTTGCCCTGGA
ACTTGGGTTACAGGTGATGCGGATGACCTTATCAACCCTTAACTGGAGACGCAGGGAGATGGTACGATGGTTGGTGACCTGTGCTACAGA
AGTGGGTGTGCGGGCCCTGGTGAGCATCTTGCAGAGCTGGTACACACTCTTCACCCCTACTGAGGCTACTAGTATTGTAGCTGCCACAGC
CGTATCCCACACCACTATCCTGCGCCTCAGTCTTGACTATCCACAGCGGGAGGAACTGGCTAGCTGTGCTCGCACACTGGCTCTACAGTG
TGCTATGAAGGATCCACAGAGCTGTGCCCTGTCAGCCCTTACACTCTGTGAGAAAGACCACATTGCCTTTGAGGCAGCCTACCAGATTGC
CATTGATGCTGCTGCTGGTGGTATGACCCATTCACAGCTGTTCACCATCGCCCGCTACATGGAGCTCCGTGGCTACCCGCTACGTGCCTT
CAAGCTGGCCTCATTGGCCATGAGCCATCTTAACCTGGCCTACAACCAGGATACTCACCCAGCCATCAATGATGTGCTCTGGGCTTGTGC
TCTCAGCCACTCTCTGGGCAAGAATGAGCTGGCAGCTCTCATCCCCCTGGTGGTGAAGAGTGTGCACTGTGCCACAGTGCTTTCAGACAT
CTTACGACGCTGCACAGTGACTGCACCTGGCCTGGCCGGCATCCCAGGCCGCCGAAGCTCTGGAAAGCTCATGTCCACTGACAAAGCTCC
ATTGCGCCAGTTGCTGGATGCCACCATCAATGCCTATATCAACACTACACACTCACGCCTAACACACATCAGCCCTCGCCACTATGGAGA
GTTCATTGAGTTTCTAAGCAAGGCTCGGGAGACCTTCCTGCTGCCCCAGGATGGCCACCTGCAGTTTGCCCAGTTCATCGACAACCTCAA
ACAGATCTACAAAGGCAAGAAAAAGTTGATGCTGCTGGTGCGAGAGCGCTTTGGCTGAGAGAGCAGATAGCTCACTGCCAGAGCAGCCTG
GGTTCCCAGGTAGTATCAGGTCAGGCCAAGGGCACTGAAACATTTGTCCACCCTGAGAGAACTCTGAGCACCTGTGGATGAGGCCAAAGG
ACCACAGGGCTAAGGATGGGGAAAGTCCAGCTCTAGTCGATAATGCCTACCTTGGCAAGCTTCTGACTACAGCCTACTGTTCATGGAGGA
GCTGGGCCCTGCAGATCGACCAGAAACCCCACAACATGCCACCTCATGCCCCTATATCCTGCGTGTCCTGAGCATTGGCCCTGTCTCCCT
TGGCAAACACAGAACACTGTTCCATCTCAGGGATTGCTTAACCAGAGAAACAGACACATTTGTGGGACTGTAAATACTATATGTGTTGCT
AATTATTGTAAACTTGTAACTATTTATAATTCTGCTTCTGATTTGATGGGCACTTGAAGTAGCTGTGGGTAGGAGGATATGCTTATTTTC
TGAGGAGACTCACAACCATTTCTCAGGTTTCCCTTGCAGAGTGTTTGCTGGTAGCAGTGGAAGAGTGGGGGTGCCAAGGAGAAAAATGGC
CAGTTAGGATCAACCCAAGTCTAGTCTATGCAGAATCCCCCACCTACAGACAGGGCATTTATAGTCCAGTGGTGAGTGAGGGACAGAGGC
CAGGACTGGACTTAGACTTTTGCCTCACAAAACTGTGAGGACATTGAAGCTCCTGCCTCACACAGCCTCTTCAGGAGCCTGCTGAACACC
TGAGAAACAAGTGCAGGGAGAAGATGAAGGTCTGGGAAGCCGCTGAGTTCATAATATTCATCTACTGTGGTCACCTTTGTGTTAGCAAGT
GTGTGGTTTCATCTATAATTGTGTGTGTGTATCTTTATGGCTAAGTACATGTGTGTATGTACATAGATACATCTGTGCATGCCTGTTTGT
GCACATATATATTTATGTGTATGTGTCAGTTCTATGGCTGTGTACCTGTTTGAATATGTGCACACTGGACTGTGAGTTTCTACGTGAGGA
TATACACATTTTGTGTACATGTGAGGATGCACATCTTTGTGCAAATGCACTCATGTTTGTGCATGTTTAGTATGTGTATCTGCGTACACG
AGTGCATGTGTATAAACATGTTTGTATCCATGTGTATGCTTGTTATCCATGCATCTGTGTCTTTATATGTGTAACTGAGCGTATTTCTAC
ATGTAGGGATGTCTGTGTATTCATGTTTGAGGATCTGCATCAATGTGTCCTTTTTGCCAGATTTCTCTTTCCCATTCCTCTTAAATCTCT
CTCGCCAGCTAAACGTTTGTTCCCCATCTCTGTGCCTCCTCTATTCATTCTCTCACCAAACAAGCTTCTAAGCACCAATCTCCCTCTGCC
ATCAGATTGGCTGCTTTAGCTCCATAGTTCTCTTCTCGCCTCATACTTGCTTTCTTCCCCTGCCTTTCTACCTCAAGCTTCCTCGCCGGC
TTTTGTCACAGTCTCATTGCTCGCTGACTTGGAGGCTAGGGCTGGTCTGCACTTAGCCTCTCCCTTCCTAATTTCTAGCCCTAGTGGGCA
GTCCTGTCTTAGCCCTGGCTGACCTCCATAGTGTATCATGTTCCTGCTACCTTCCTGACCCCTGTGCTCAGCCTGGAATTGTTATAGGAG
GTAGCAAGGGCACTCAGAAAAGTCAGTTGGAACCAGTGTCTTGGTGTTTACTGTTTCATGTCTTAGTTCCTGAGTTGGGGGTGGGGTTTG
ATAGGGAAGGGGTGGTATAGCTAGAATGTGAACTAAGAACTTCTCCATCTGCTTTACTTTTTCTTTCTTCGACAAACTGTCACCTTTTTT
ACTCCAAACTGACCAAGAAGTTGTATTTGCCATTTGTGGCTACTCAAGTCTTACTGTCCAGCCAAGGGCCCCTACGTCTCAGCCCAATGG
GTTGGTTAAAAAAAAGAGAGAAGCCACTCTCATTTCTGTATCACAGTTGCCCTTTTTTAGCAAGTGTGTGAATTCACAGTGCTTTTCTAT

>In-frame_ENST00000227503_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(amino acids)=1040AA_start in transcript=355_stop in transcript=3477
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTC
GCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAG
ASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWD
ELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALPQSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQ
RIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTI
TNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKV
CRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSASAG
DTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVA
LELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLAL
QCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWA
CALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHY

--------------------------------------------------------------
>In-frame_ENST00000334944_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(transcript)=5572nt_BP=554nt
CGGAGCTCAGTTCACGCAGTAACAAATGAAGTGCGCGCTGCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTA
ACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCC
CAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGC
CGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGA
AAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAG
GAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGA
AAGAGCTTATATAGGCTTTCATCTGAGTGGCACAGTAACTGAGCTGGCCACTGCCTCTGAACCAGCAGTGACTTATAAAGTTGCAATCAG
TTTTGATCGATGCAAAATCACCTCAGTGACATGTGGCTGTGGGAACAAGGACATATTCTACTGTGCCCATGTGGTAGCACTCTCACTCTA
CAGGATCCGTAAACCAGACCAAGTCAAATTGCGTCTTCCTATCTCCGAAACCCTTTTCCAGATGAATAGGGACCAGCTACAAAAGTTTAT
TCAATATTTAATCACGGCACACCACACTGAAGTTCTTCCTACTGCACAGAAACTGGCAGATGAGATTCTATCCTCCAACTCAGAAATCAA
CCAAGTGAATGGTGCCCCTGACCCCACAGCTGGGGCCAGCATTGACGATGAGAACTGTTGGCATTTGGATGAAGAACAGGTGAAAGAACA
AGTGAAGCTTTTTCTCTCCCAGGGCGGTTACTGTGGCTCTGGAAAGCAACTCAACTCAATGTTTGCCAAGGTTCGAGAAATGCTGCGGAT
GAGAGATTCCAATGGAGCAAGGATGCTGACACTAATAACTGAGCAGTTTGTGGCTGACCCACGACTCACACTCTGGAGGCAGCAAGGAAC
AAACATGACAGACAAGTGCAGGCAGCTCTGGGATGAGCTAGGGGCTTTATGGGTGTGCATAATTTTAAATCCACACTGCAAACTGGAGGA
GAAATCCTGCTGGCTGCAGCAGCTGCAGAAGTGGAGCGACCTGGATGTCTGTCCCCTGGAGGATGGAAACTATGGACATGAGCTGCCCAA
CATCACCAATGCACTTCCCCAGAGTGCCATTCACAGCCCAGACTCCTTATCCAGACCAAGACGAACAGTATTCACTAGAGCCATTGAGGG
GCGTGAATTACATTGGCAGGATAGCCACCTACAGCGAATAATCAGCAGTGATGTTTATACAGCTCCTGCCTGCCAGCGGGAAAGTGAAAG
ACTACTCTTTAATTCCCAAGGCCAGCCACTGTGGCTTGAGCATGTGCCTACAGCCTGTGCTCGAGTTGACGCCCTGCGTTCCCATGGTTA
TCCAAAAGAGGCCCTCAGACTCACAGTGGCCATTATTAATACTCTGAGGTTGCAGCAGCAGCGGCAACTGGAAATCTACAAGCATCAGAA
GAAAGAACTGTTGCAGAGAGGAACCACAACCATCACAAACCTGGAGGGCTGGGTGGGCCACCCCCTGGATCCCATCGACTGCCTGTTTCT
CACTTTGACTGAGGCCTGCCGCCTGAATGATGATGGCTATCTGGAGATGTCAGATATGAATGAAAGCAGACCCCCTGTGTACCAGCATGT
ACCTGTGGCTGCAGGCTCCCCAAACAGCAGTGAGTCCTACCTGTCATTGGCCCTGGAAGTTGCACTGATGGGCCTGGGTCAACAGAGGTT
AATGCCTGAAGGCCTCTACGCACAGGACAAGGTATGCCGTAATGAGGAGCAGCTCCTGAGCCAACTCCAAGAGCTGCAGCTGGACGATGA
GCTAGTGCAAACACTGCAAAAACAATGCATCTTACTGCTGGAAGGAGGTCCTTTCAGCGGTCTGGGAGAAGTCATCCACCGAGAGAGTGT
TCCCATGCATACCTTTGCCAAGTATTTGTTCTCAGCTCTGCTGCCTCATGATCCAGACCTGTCCTATAAATTAGCCTTACGTGCCATGAG
GTTACCTGTTTTAGAAAACTCAGCTTCTGCAGGCGACACATCCCACCCTCACCATATGGTGTCTGTGGTGCCCAGCCGTTATCCTCGCTG
GTTCACGCTTGGACACTTGGAATCACAGCAGTGTGAACTGGCCTCCACCATGCTGACTGCTGCCAAAGGAGACACTTTGAGACTCCGAAC
AATTCTGGAAGCAATACAGAAGCACATTCATTCTTCCTCCCTCATCTTCAAACTGGCCCAAGATGCATTCAAGATTGCTACTCCCACCGA
CAGTAGTACTGACAGCACCCTGCTCAACGTTGCCCTGGAACTTGGGTTACAGGTGATGCGGATGACCTTATCAACCCTTAACTGGAGACG
CAGGGAGATGGTACGATGGTTGGTGACCTGTGCTACAGAAGTGGGTGTGCGGGCCCTGGTGAGCATCTTGCAGAGCTGGTACACACTCTT
CACCCCTACTGAGGCTACTAGTATTGTAGCTGCCACAGCCGTATCCCACACCACTATCCTGCGCCTCAGTCTTGACTATCCACAGCGGGA
GGAACTGGCTAGCTGTGCTCGCACACTGGCTCTACAGTGTGCTATGAAGGATCCACAGAGCTGTGCCCTGTCAGCCCTTACACTCTGTGA
GAAAGACCACATTGCCTTTGAGGCAGCCTACCAGATTGCCATTGATGCTGCTGCTGGTGGTATGACCCATTCACAGCTGTTCACCATCGC
CCGCTACATGGAGCTCCGTGGCTACCCGCTACGTGCCTTCAAGCTGGCCTCATTGGCCATGAGCCATCTTAACCTGGCCTACAACCAGGA
TACTCACCCAGCCATCAATGATGTGCTCTGGGCTTGTGCTCTCAGCCACTCTCTGGGCAAGAATGAGCTGGCAGCTCTCATCCCCCTGGT
GGTGAAGAGTGTGCACTGTGCCACAGTGCTTTCAGACATCTTACGACGCTGCACAGTGACTGCACCTGGCCTGGCCGGCATCCCAGGCCG
CCGAAGCTCTGGAAAGCTCATGTCCACTGACAAAGCTCCATTGCGCCAGTTGCTGGATGCCACCATCAATGCCTATATCAACACTACACA
CTCACGCCTAACACACATCAGCCCTCGCCACTATGGAGAGTTCATTGAGTTTCTAAGCAAGGCTCGGGAGACCTTCCTGCTGCCCCAGGA
TGGCCACCTGCAGTTTGCCCAGTTCATCGACAACCTCAAACAGATCTACAAAGGCAAGAAAAAGTTGATGCTGCTGGTGCGAGAGCGCTT
TGGCTGAGAGAGCAGATAGCTCACTGCCAGAGCAGCCTGGGTTCCCAGGTAGTATCAGGTCAGGCCAAGGGCACTGAAACATTTGTCCAC
CCTGAGAGAACTCTGAGCACCTGTGGATGAGGCCAAAGGACCACAGGGCTAAGGATGGGGAAAGTCCAGCTCTAGTCGATAATGCCTACC
TTGGCAAGCTTCTGACTACAGCCTACTGTTCATGGAGGAGCTGGGCCCTGCAGATCGACCAGAAACCCCACAACATGCCACCTCATGCCC
CTATATCCTGCGTGTCCTGAGCATTGGCCCTGTCTCCCTTGGCAAACACAGAACACTGTTCCATCTCAGGGATTGCTTAACCAGAGAAAC
AGACACATTTGTGGGACTGTAAATACTATATGTGTTGCTAATTATTGTAAACTTGTAACTATTTATAATTCTGCTTCTGATTTGATGGGC
ACTTGAAGTAGCTGTGGGTAGGAGGATATGCTTATTTTCTGAGGAGACTCACAACCATTTCTCAGGTTTCCCTTGCAGAGTGTTTGCTGG
TAGCAGTGGAAGAGTGGGGGTGCCAAGGAGAAAAATGGCCAGTTAGGATCAACCCAAGTCTAGTCTATGCAGAATCCCCCACCTACAGAC
AGGGCATTTATAGTCCAGTGGTGAGTGAGGGACAGAGGCCAGGACTGGACTTAGACTTTTGCCTCACAAAACTGTGAGGACATTGAAGCT
CCTGCCTCACACAGCCTCTTCAGGAGCCTGCTGAACACCTGAGAAACAAGTGCAGGGAGAAGATGAAGGTCTGGGAAGCCGCTGAGTTCA
TAATATTCATCTACTGTGGTCACCTTTGTGTTAGCAAGTGTGTGGTTTCATCTATAATTGTGTGTGTGTATCTTTATGGCTAAGTACATG
TGTGTATGTACATAGATACATCTGTGCATGCCTGTTTGTGCACATATATATTTATGTGTATGTGTCAGTTCTATGGCTGTGTACCTGTTT
GAATATGTGCACACTGGACTGTGAGTTTCTACGTGAGGATATACACATTTTGTGTACATGTGAGGATGCACATCTTTGTGCAAATGCACT
CATGTTTGTGCATGTTTAGTATGTGTATCTGCGTACACGAGTGCATGTGTATAAACATGTTTGTATCCATGTGTATGCTTGTTATCCATG
CATCTGTGTCTTTATATGTGTAACTGAGCGTATTTCTACATGTAGGGATGTCTGTGTATTCATGTTTGAGGATCTGCATCAATGTGTCCT
TTTTGCCAGATTTCTCTTTCCCATTCCTCTTAAATCTCTCTCGCCAGCTAAACGTTTGTTCCCCATCTCTGTGCCTCCTCTATTCATTCT
CTCACCAAACAAGCTTCTAAGCACCAATCTCCCTCTGCCATCAGATTGGCTGCTTTAGCTCCATAGTTCTCTTCTCGCCTCATACTTGCT
TTCTTCCCCTGCCTTTCTACCTCAAGCTTCCTCGCCGGCTTTTGTCACAGTCTCATTGCTCGCTGACTTGGAGGCTAGGGCTGGTCTGCA
CTTAGCCTCTCCCTTCCTAATTTCTAGCCCTAGTGGGCAGTCCTGTCTTAGCCCTGGCTGACCTCCATAGTGTATCATGTTCCTGCTACC
TTCCTGACCCCTGTGCTCAGCCTGGAATTGTTATAGGAGGTAGCAAGGGCACTCAGAAAAGTCAGTTGGAACCAGTGTCTTGGTGTTTAC
TGTTTCATGTCTTAGTTCCTGAGTTGGGGGTGGGGTTTGATAGGGAAGGGGTGGTATAGCTAGAATGTGAACTAAGAACTTCTCCATCTG
CTTTACTTTTTCTTTCTTCGACAAACTGTCACCTTTTTTACTCCAAACTGACCAAGAAGTTGTATTTGCCATTTGTGGCTACTCAAGTCT
TACTGTCCAGCCAAGGGCCCCTACGTCTCAGCCCAATGGGTTGGTTAAAAAAAAGAGAGAAGCCACTCTCATTTCTGTATCACAGTTGCC

>In-frame_ENST00000334944_ENST00000359600_TCGA-EY-A3QX-01A_SF1_chr11_64543970_-_ZSWIM5_chr1_45553909_length(amino acids)=1040AA_start in transcript=394_stop in transcript=3516
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGFHLSGTVTELATASEPAVTYKVAISFDRCKITSVTC
GCGNKDIFYCAHVVALSLYRIRKPDQVKLRLPISETLFQMNRDQLQKFIQYLITAHHTEVLPTAQKLADEILSSNSEINQVNGAPDPTAG
ASIDDENCWHLDEEQVKEQVKLFLSQGGYCGSGKQLNSMFAKVREMLRMRDSNGARMLTLITEQFVADPRLTLWRQQGTNMTDKCRQLWD
ELGALWVCIILNPHCKLEEKSCWLQQLQKWSDLDVCPLEDGNYGHELPNITNALPQSAIHSPDSLSRPRRTVFTRAIEGRELHWQDSHLQ
RIISSDVYTAPACQRESERLLFNSQGQPLWLEHVPTACARVDALRSHGYPKEALRLTVAIINTLRLQQQRQLEIYKHQKKELLQRGTTTI
TNLEGWVGHPLDPIDCLFLTLTEACRLNDDGYLEMSDMNESRPPVYQHVPVAAGSPNSSESYLSLALEVALMGLGQQRLMPEGLYAQDKV
CRNEEQLLSQLQELQLDDELVQTLQKQCILLLEGGPFSGLGEVIHRESVPMHTFAKYLFSALLPHDPDLSYKLALRAMRLPVLENSASAG
DTSHPHHMVSVVPSRYPRWFTLGHLESQQCELASTMLTAAKGDTLRLRTILEAIQKHIHSSSLIFKLAQDAFKIATPTDSSTDSTLLNVA
LELGLQVMRMTLSTLNWRRREMVRWLVTCATEVGVRALVSILQSWYTLFTPTEATSIVAATAVSHTTILRLSLDYPQREELASCARTLAL
QCAMKDPQSCALSALTLCEKDHIAFEAAYQIAIDAAAGGMTHSQLFTIARYMELRGYPLRAFKLASLAMSHLNLAYNQDTHPAINDVLWA
CALSHSLGKNELAALIPLVVKSVHCATVLSDILRRCTVTAPGLAGIPGRRSSGKLMSTDKAPLRQLLDATINAYINTTHSRLTHISPRHY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SF1-ZSWIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SF1-ZSWIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SF1-ZSWIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSF1C0025202melanoma1CTD_human
TgeneZSWIM5C0006142Malignant neoplasm of breast1CTD_human
TgeneZSWIM5C0678222Breast Carcinoma1CTD_human
TgeneZSWIM5C1257931Mammary Neoplasms, Human1CTD_human
TgeneZSWIM5C1458155Mammary Neoplasms1CTD_human
TgeneZSWIM5C4704874Mammary Carcinoma, Human1CTD_human