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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SFPQ-TFE3 (FusionGDB2 ID:80567)

Fusion Gene Summary for SFPQ-TFE3

check button Fusion gene summary
Fusion gene informationFusion gene name: SFPQ-TFE3
Fusion gene ID: 80567
HgeneTgene
Gene symbol

SFPQ

TFE3

Gene ID

654780

7030

Gene namesplicing factor proline/glutamine-richtranscription factor binding to IGHM enhancer 3
SynonymsSFPQRCCP2|RCCX1|TFEA|bHLHe33
Cytomap

16q24.1

Xp11.23

Type of genencRNAprotein-coding
Description-transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
Modification date2020030320200327
UniProtAcc.

P19532

Ensembl transtripts involved in fusion geneENST00000357214, ENST00000468598, 
ENST00000315869, ENST00000487451, 
Fusion gene scores* DoF score14 X 16 X 8=179214 X 15 X 6=1260
# samples 1915
** MAII scorelog2(19/1792*10)=-3.23749931372666
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFPQ [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSFPQ(35654604)-TFE3(48898095), # samples:14
TFE3(48900637)-SFPQ(35653691), # samples:3
Anticipated loss of major functional domain due to fusion event.TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TFE3-SFPQ seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SFPQ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-AK-3456-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-B0-5705-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-B8-5546-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-BP-4756-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-BP-4758-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SO-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SOSFPQchr1

35654603

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501SFPQchr1

35654603

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-B8-5546-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-AK-3456-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-BP-4758-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SOSFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501SFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-AK-3456-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-B0-5705-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-B8-5546-01ASFPQchr1

35652602

-TFE3chrX

48891766

-
ChimerDB4KIRCTCGA-BP-4756-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRCTCGA-BP-4758-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-G7-7501-01ASFPQchr1

35654604

-TFE3chrX

48898095

-
ChimerDB4KIRPTCGA-SX-A7SO-01ASFPQchr1

35654604

-TFE3chrX

48898095

-


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Fusion Gene ORF analysis for SFPQ-TFE3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000357214ENST00000315869SFPQchr1

35654604

-TFE3chrX

48898095

-
5CDS-intronENST00000357214ENST00000487451SFPQchr1

35654604

-TFE3chrX

48898095

-
intron-3CDSENST00000468598ENST00000315869SFPQchr1

35654604

-TFE3chrX

48898095

-
intron-intronENST00000468598ENST00000487451SFPQchr1

35654604

-TFE3chrX

48898095

-
In-frameENST00000357214ENST00000315869SFPQchr1

35652602

-TFE3chrX

48891766

-
5CDS-5UTRENST00000357214ENST00000487451SFPQchr1

35652602

-TFE3chrX

48891766

-
intron-3CDSENST00000468598ENST00000315869SFPQchr1

35652602

-TFE3chrX

48891766

-
intron-5UTRENST00000468598ENST00000487451SFPQchr1

35652602

-TFE3chrX

48891766

-
In-frameENST00000357214ENST00000315869SFPQchr1

35654603

-TFE3chrX

48898095

-
5CDS-intronENST00000357214ENST00000487451SFPQchr1

35654603

-TFE3chrX

48898095

-
intron-3CDSENST00000468598ENST00000315869SFPQchr1

35654603

-TFE3chrX

48898095

-
intron-intronENST00000468598ENST00000487451SFPQchr1

35654603

-TFE3chrX

48898095

-
5CDS-5UTRENST00000357214ENST00000487451SFPQchr1

35654603

-TFE3chrX

48891055

-
Frame-shiftENST00000357214ENST00000315869SFPQchr1

35654603

-TFE3chrX

48891055

-
intron-3CDSENST00000468598ENST00000315869SFPQchr1

35654603

-TFE3chrX

48891055

-
intron-5UTRENST00000468598ENST00000487451SFPQchr1

35654603

-TFE3chrX

48891055

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000357214SFPQchr135654604-ENST00000315869TFE3chrX48898095-483517968734071106
ENST00000357214SFPQchr135652602-ENST00000315869TFE3chrX48891766-43552085872927946
ENST00000357214SFPQchr135654603-ENST00000315869TFE3chrX48898095-483517968734071106

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357214ENST00000315869SFPQchr135654604-TFE3chrX48898095-0.0053817270.99461836
ENST00000357214ENST00000315869SFPQchr135652602-TFE3chrX48891766-0.0079983310.99200165
ENST00000357214ENST00000315869SFPQchr135654603-TFE3chrX48898095-0.0053817270.99461836

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Fusion Genomic Features for SFPQ-TFE3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SFPQ-TFE3


check button Go to

FGviewer for the breakpoints of chr1:35654604-chrX:48898095

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TFE3

P19532

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910497_596662.0708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91010_15662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91010_266662.0708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910184_188662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91020_27662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91056_65662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910571_574662.0708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910613_616662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910635_641662.0708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91067_71662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91095_98662.0708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91099_103662.0708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61010_15565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61010_266565.6666666666666708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610184_188565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61020_27565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61056_65565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61067_71565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61095_98565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61099_103565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61010_15565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61010_266565.6666666666666708.0Compositional biasNote=Gln/Glu/Pro-rich
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610184_188565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61020_27565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61056_65565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61067_71565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61095_98565.6666666666666708.0Compositional biasNote=Poly-Gln
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61099_103565.6666666666666708.0Compositional biasNote=Poly-Pro
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910297_369662.0708.0DomainRRM 1
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-910371_452662.0708.0DomainRRM 2
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610297_369565.6666666666666708.0DomainRRM 1
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610371_452565.6666666666666708.0DomainRRM 2
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610297_369565.6666666666666708.0DomainRRM 1
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610371_452565.6666666666666708.0DomainRRM 2
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-9109_27662.0708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-6109_27565.6666666666666708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-6109_27565.6666666666666708.0RegionNote=3 X 3 AA repeats of R-G-G
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91019_21662.0708.0RepeatNote=2
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-91025_27662.0708.0RepeatNote=3
HgeneSFPQchr1:35652602chrX:48891766ENST00000357214-9109_11662.0708.0RepeatNote=1
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61019_21565.6666666666666708.0RepeatNote=2
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-61025_27565.6666666666666708.0RepeatNote=3
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-6109_11565.6666666666666708.0RepeatNote=1
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61019_21565.6666666666666708.0RepeatNote=2
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-61025_27565.6666666666666708.0RepeatNote=3
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-6109_11565.6666666666666708.0RepeatNote=1
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410346_399295.0576.0DomainbHLH
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010346_39938.666666666666664576.0DomainbHLH
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010346_39938.666666666666664576.0DomainbHLH
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410409_430295.0576.0RegionNote=Leucine-zipper
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010260_27138.666666666666664576.0RegionStrong transcription activation domain
TgeneTFE3chr1:35654603chrX:48898095ENST00000315869010409_43038.666666666666664576.0RegionNote=Leucine-zipper
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010260_27138.666666666666664576.0RegionStrong transcription activation domain
TgeneTFE3chr1:35654604chrX:48898095ENST00000315869010409_43038.666666666666664576.0RegionNote=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610497_596565.6666666666666708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610497_596565.6666666666666708.0Coiled coilOntology_term=ECO:0000255,ECO:0000269
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610571_574565.6666666666666708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610613_616565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654603chrX:48898095ENST00000357214-610635_641565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610571_574565.6666666666666708.0Compositional biasNote=Poly-Arg
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610613_616565.6666666666666708.0Compositional biasNote=Poly-Gly
HgeneSFPQchr1:35654604chrX:48898095ENST00000357214-610635_641565.6666666666666708.0Compositional biasNote=Poly-Gly
TgeneTFE3chr1:35652602chrX:48891766ENST00000315869410260_271295.0576.0RegionStrong transcription activation domain


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Fusion Gene Sequence for SFPQ-TFE3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000357214_ENST00000315869_TCGA-AK-3456-01A_SFPQ_chr1_35654604_-_TFE3_chrX_48898095_length(transcript)=4835nt_BP=1796nt
GCCGCCTGTGTCATCCGCCATTTTGTGAGAAGCAAGGTGGCCTCCACGTTTCCTGAGCGTCTTCTTCGCTTTTGCCTCGACCGCCCCTTG
ACCACAGACATGTCTCGGGATCGGTTCCGGAGTCGTGGCGGTGGCGGTGGTGGCTTCCACAGGCGTGGAGGAGGCGGCGGCCGCGGCGGC
CTCCACGACTTCCGTTCTCCGCCGCCCGGCATGGGCCTCAATCAGAATCGCGGCCCCATGGGTCCTGGCCCGGGCCAGAGCGGCCCTAAG
CCTCCGATCCCGCCACCGCCTCCACACCAACAGCAGCAACAGCCACCACCGCAGCAGCCACCGCCGCAGCAGCCGCCACCGCATCAGCCG
CCGCCGCATCCACAGCCGCATCAGCAGCAGCAGCCGCCGCCACCGCCGCAGGACTCTTCCAAGCCCGTCGTTGCTCAGGGACCCGGCCCC
GCTCCCGGAGTAGGCAGCGCACCACCAGCCTCCAGCTCGGCCCCGCCCGCCACTCCACCAACCTCGGGGGCCCCGCCAGGGTCCGGGCCA
GGCCCGACTCCGACCCCGCCGCCTGCAGTCACCTCGGCCCCTCCCGGGGCGCCGCCACCCACCCCGCCAAGCAGCGGGGTCCCTACCACA
CCTCCTCAGGCCGGAGGCCCGCCGCCTCCGCCCGCGGCAGTCCCGGGCCCGGGTCCAGGGCCTAAGCAGGGCCCAGGTCCGGGTGGTCCC
AAAGGCGGCAAAATGCCTGGCGGGCCGAAGCCAGGTGGCGGCCCGGGCCTAAGTACGCCTGGCGGCCACCCCAAGCCGCCGCATCGAGGC
GGCGGGGAGCCCCGCGGGGGCCGCCAGCACCACCCGCCCTACCACCAGCAGCATCACCAGGGGCCCCCGCCCGGCGGGCCCGGCGGCCGC
AGCGAGGAGAAGATCTCGGACTCGGAGGGGTTTAAAGCCAATTTGTCTCTCTTGAGGAGGCCTGGAGAGAAAACTTACACACAGCGATGT
CGGTTGTTTGTTGGGAATCTACCTGCTGATATCACGGAGGATGAATTCAAAAGACTATTTGCTAAATATGGAGAACCAGGAGAAGTTTTT
ATCAACAAAGGCAAAGGATTCGGATTTATTAAGCTTGAATCTAGAGCTTTGGCTGAAATTGCCAAAGCCGAACTGGATGATACACCCATG
AGAGGTAGACAGCTTCGAGTTCGCTTTGCCACACATGCTGCTGCCCTTTCTGTTCGTAATCTTTCACCTTATGTTTCCAATGAACTGTTG
GAAGAAGCCTTTAGCCAATTTGGTCCTATTGAAAGGGCTGTTGTAATAGTGGATGATCGTGGAAGATCTACAGGGAAAGGCATTGTTGAA
TTTGCTTCTAAGCCAGCAGCAAGAAAGGCATTTGAACGATGCAGTGAAGGTGTTTTCTTACTGACGACAACTCCTCGTCCAGTCATTGTG
GAACCACTTGAACAACTAGATGATGAAGATGGTCTTCCTGAAAAACTTGCCCAGAAGAATCCAATGTATCAAAAGGAGAGAGAAACCCCT
CCTCGTTTTGCCCAGCATGGCACGTTTGAGTACGAATATTCTCAGCGATGGAAGTCTTTGGATGAAATGGAAAAACAGCAAAGGGAACAA
GTTGAAAAAAACATGAAAGATGCAAAAGACAAATTGGAAAGTGAAATGGAAGATGCCTATCATGAACATCAGGCAAATCTTTTGCGCCAA
GATCTGATGAGACGACAGGAAGAATTAAGACGCATGGAAGAACTTCACAATCAAGAAATGCAGAAACGTAAAGAAATGCAATTGAGCCTG
AACTCTTTGCTTCCGGAATCCGGGATTGTTGCTGACATAGAATTAGAAAACGTCCTTGATCCTGACAGCTTCTACGAGCTCAAAAGCCAA
CCCTTACCCCTTCGCTCAAGCCTCCCAATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTGCATCGTCTTCTGCAGGGGGC
TCCAGGACCCCTGCCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCCAGGCGCAGGAGCAGGAGAGG
CGTGAGCGTCGGGAACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTGTGGTTGGCGTCTCTGCTGGG
GGCCACACATTGAGCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGGAGAACCCAACGCGCTACCAC
CTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCG
GGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTG
CTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTC
AGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGC
GTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCC
CTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGC
ACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAG
AAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTA
GAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAG
CCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAG
CAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGG
CTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCC
CTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACC
CCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCC
CAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCC
CAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCA
CCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCA
GGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTC
AAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGA
GGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCC
AGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCA
ACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAG
GGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCC
CCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAG
AACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTG
GAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCT
CCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAG
ACACTCCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTG

>In-frame_ENST00000357214_ENST00000315869_TCGA-AK-3456-01A_SFPQ_chr1_35654604_-_TFE3_chrX_48898095_length(amino acids)=1106AA_start in transcript=87_stop in transcript=3407
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAG
GSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRY
HLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEM
LSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKEL
GTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSL
KPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASD

--------------------------------------------------------------
>In-frame_ENST00000357214_ENST00000315869_TCGA-B0-5705-01A_SFPQ_chr1_35652602_-_TFE3_chrX_48891766_length(transcript)=4355nt_BP=2085nt
GCCGCCTGTGTCATCCGCCATTTTGTGAGAAGCAAGGTGGCCTCCACGTTTCCTGAGCGTCTTCTTCGCTTTTGCCTCGACCGCCCCTTG
ACCACAGACATGTCTCGGGATCGGTTCCGGAGTCGTGGCGGTGGCGGTGGTGGCTTCCACAGGCGTGGAGGAGGCGGCGGCCGCGGCGGC
CTCCACGACTTCCGTTCTCCGCCGCCCGGCATGGGCCTCAATCAGAATCGCGGCCCCATGGGTCCTGGCCCGGGCCAGAGCGGCCCTAAG
CCTCCGATCCCGCCACCGCCTCCACACCAACAGCAGCAACAGCCACCACCGCAGCAGCCACCGCCGCAGCAGCCGCCACCGCATCAGCCG
CCGCCGCATCCACAGCCGCATCAGCAGCAGCAGCCGCCGCCACCGCCGCAGGACTCTTCCAAGCCCGTCGTTGCTCAGGGACCCGGCCCC
GCTCCCGGAGTAGGCAGCGCACCACCAGCCTCCAGCTCGGCCCCGCCCGCCACTCCACCAACCTCGGGGGCCCCGCCAGGGTCCGGGCCA
GGCCCGACTCCGACCCCGCCGCCTGCAGTCACCTCGGCCCCTCCCGGGGCGCCGCCACCCACCCCGCCAAGCAGCGGGGTCCCTACCACA
CCTCCTCAGGCCGGAGGCCCGCCGCCTCCGCCCGCGGCAGTCCCGGGCCCGGGTCCAGGGCCTAAGCAGGGCCCAGGTCCGGGTGGTCCC
AAAGGCGGCAAAATGCCTGGCGGGCCGAAGCCAGGTGGCGGCCCGGGCCTAAGTACGCCTGGCGGCCACCCCAAGCCGCCGCATCGAGGC
GGCGGGGAGCCCCGCGGGGGCCGCCAGCACCACCCGCCCTACCACCAGCAGCATCACCAGGGGCCCCCGCCCGGCGGGCCCGGCGGCCGC
AGCGAGGAGAAGATCTCGGACTCGGAGGGGTTTAAAGCCAATTTGTCTCTCTTGAGGAGGCCTGGAGAGAAAACTTACACACAGCGATGT
CGGTTGTTTGTTGGGAATCTACCTGCTGATATCACGGAGGATGAATTCAAAAGACTATTTGCTAAATATGGAGAACCAGGAGAAGTTTTT
ATCAACAAAGGCAAAGGATTCGGATTTATTAAGCTTGAATCTAGAGCTTTGGCTGAAATTGCCAAAGCCGAACTGGATGATACACCCATG
AGAGGTAGACAGCTTCGAGTTCGCTTTGCCACACATGCTGCTGCCCTTTCTGTTCGTAATCTTTCACCTTATGTTTCCAATGAACTGTTG
GAAGAAGCCTTTAGCCAATTTGGTCCTATTGAAAGGGCTGTTGTAATAGTGGATGATCGTGGAAGATCTACAGGGAAAGGCATTGTTGAA
TTTGCTTCTAAGCCAGCAGCAAGAAAGGCATTTGAACGATGCAGTGAAGGTGTTTTCTTACTGACGACAACTCCTCGTCCAGTCATTGTG
GAACCACTTGAACAACTAGATGATGAAGATGGTCTTCCTGAAAAACTTGCCCAGAAGAATCCAATGTATCAAAAGGAGAGAGAAACCCCT
CCTCGTTTTGCCCAGCATGGCACGTTTGAGTACGAATATTCTCAGCGATGGAAGTCTTTGGATGAAATGGAAAAACAGCAAAGGGAACAA
GTTGAAAAAAACATGAAAGATGCAAAAGACAAATTGGAAAGTGAAATGGAAGATGCCTATCATGAACATCAGGCAAATCTTTTGCGCCAA
GATCTGATGAGACGACAGGAAGAATTAAGACGCATGGAAGAACTTCACAATCAAGAAATGCAGAAACGTAAAGAAATGCAATTGAGGCAA
GAGGAGGAACGACGTAGAAGAGAGGAAGAGATGATGATTCGTCAACGTGAGATGGAAGAACAAATGAGGCGCCAAAGAGAGGAAAGTTAC
AGCCGAATGGGCTACATGGATCCACGGGAAAGAGACATGCGAATGGGTGGCGGAGGAGCAATGAACATGGGAGATCCCTATGGTTCAGGA
GGCCAGAAATTTCCACCTCTAGGAGGTGGTGGTGGCATAGGTTATGAAGCTAATCCTGGCGTTCCACCAGCAACCATGAGTGGTTCCATG
ATGGGAAGTGACATGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAAC
TCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAAT
CACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAG
ATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAG
AGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCA
GTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGC
AGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTT
CTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAG
GGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCC
AAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGAAAG
GAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGTGAT
CAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTTCAG
AAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTGCCC
AGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGGATG
TTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGGTTT
AAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGGAAC
TCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAATCA
GTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGCAGG
GAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGGAAG
GGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTCTTC
CTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAACAT
GTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTG
GAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCCAAC
CTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTCATA
CCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAATAAT

>In-frame_ENST00000357214_ENST00000315869_TCGA-B0-5705-01A_SFPQ_chr1_35652602_-_TFE3_chrX_48891766_length(amino acids)=946AA_start in transcript=87_stop in transcript=2927
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLRQEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPYGS
GGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKD
NHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGL
PVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEE

--------------------------------------------------------------
>In-frame_ENST00000357214_ENST00000315869_TCGA-SX-A7SO_SFPQ_chr1_35654603_-_TFE3_chrX_48898095_length(transcript)=4835nt_BP=1796nt
GCCGCCTGTGTCATCCGCCATTTTGTGAGAAGCAAGGTGGCCTCCACGTTTCCTGAGCGTCTTCTTCGCTTTTGCCTCGACCGCCCCTTG
ACCACAGACATGTCTCGGGATCGGTTCCGGAGTCGTGGCGGTGGCGGTGGTGGCTTCCACAGGCGTGGAGGAGGCGGCGGCCGCGGCGGC
CTCCACGACTTCCGTTCTCCGCCGCCCGGCATGGGCCTCAATCAGAATCGCGGCCCCATGGGTCCTGGCCCGGGCCAGAGCGGCCCTAAG
CCTCCGATCCCGCCACCGCCTCCACACCAACAGCAGCAACAGCCACCACCGCAGCAGCCACCGCCGCAGCAGCCGCCACCGCATCAGCCG
CCGCCGCATCCACAGCCGCATCAGCAGCAGCAGCCGCCGCCACCGCCGCAGGACTCTTCCAAGCCCGTCGTTGCTCAGGGACCCGGCCCC
GCTCCCGGAGTAGGCAGCGCACCACCAGCCTCCAGCTCGGCCCCGCCCGCCACTCCACCAACCTCGGGGGCCCCGCCAGGGTCCGGGCCA
GGCCCGACTCCGACCCCGCCGCCTGCAGTCACCTCGGCCCCTCCCGGGGCGCCGCCACCCACCCCGCCAAGCAGCGGGGTCCCTACCACA
CCTCCTCAGGCCGGAGGCCCGCCGCCTCCGCCCGCGGCAGTCCCGGGCCCGGGTCCAGGGCCTAAGCAGGGCCCAGGTCCGGGTGGTCCC
AAAGGCGGCAAAATGCCTGGCGGGCCGAAGCCAGGTGGCGGCCCGGGCCTAAGTACGCCTGGCGGCCACCCCAAGCCGCCGCATCGAGGC
GGCGGGGAGCCCCGCGGGGGCCGCCAGCACCACCCGCCCTACCACCAGCAGCATCACCAGGGGCCCCCGCCCGGCGGGCCCGGCGGCCGC
AGCGAGGAGAAGATCTCGGACTCGGAGGGGTTTAAAGCCAATTTGTCTCTCTTGAGGAGGCCTGGAGAGAAAACTTACACACAGCGATGT
CGGTTGTTTGTTGGGAATCTACCTGCTGATATCACGGAGGATGAATTCAAAAGACTATTTGCTAAATATGGAGAACCAGGAGAAGTTTTT
ATCAACAAAGGCAAAGGATTCGGATTTATTAAGCTTGAATCTAGAGCTTTGGCTGAAATTGCCAAAGCCGAACTGGATGATACACCCATG
AGAGGTAGACAGCTTCGAGTTCGCTTTGCCACACATGCTGCTGCCCTTTCTGTTCGTAATCTTTCACCTTATGTTTCCAATGAACTGTTG
GAAGAAGCCTTTAGCCAATTTGGTCCTATTGAAAGGGCTGTTGTAATAGTGGATGATCGTGGAAGATCTACAGGGAAAGGCATTGTTGAA
TTTGCTTCTAAGCCAGCAGCAAGAAAGGCATTTGAACGATGCAGTGAAGGTGTTTTCTTACTGACGACAACTCCTCGTCCAGTCATTGTG
GAACCACTTGAACAACTAGATGATGAAGATGGTCTTCCTGAAAAACTTGCCCAGAAGAATCCAATGTATCAAAAGGAGAGAGAAACCCCT
CCTCGTTTTGCCCAGCATGGCACGTTTGAGTACGAATATTCTCAGCGATGGAAGTCTTTGGATGAAATGGAAAAACAGCAAAGGGAACAA
GTTGAAAAAAACATGAAAGATGCAAAAGACAAATTGGAAAGTGAAATGGAAGATGCCTATCATGAACATCAGGCAAATCTTTTGCGCCAA
GATCTGATGAGACGACAGGAAGAATTAAGACGCATGGAAGAACTTCACAATCAAGAAATGCAGAAACGTAAAGAAATGCAATTGAGCCTG
AACTCTTTGCTTCCGGAATCCGGGATTGTTGCTGACATAGAATTAGAAAACGTCCTTGATCCTGACAGCTTCTACGAGCTCAAAAGCCAA
CCCTTACCCCTTCGCTCAAGCCTCCCAATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTGCATCGTCTTCTGCAGGGGGC
TCCAGGACCCCTGCCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCCAGGCGCAGGAGCAGGAGAGG
CGTGAGCGTCGGGAACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTGTGGTTGGCGTCTCTGCTGGG
GGCCACACATTGAGCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGGAGAACCCAACGCGCTACCAC
CTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCG
GGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTG
CTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTC
AGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGC
GTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCC
CTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGC
ACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAG
AAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTA
GAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAG
CCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAG
CAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGG
CTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCC
CTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACC
CCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCC
CAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCC
CAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCA
CCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCA
GGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTC
AAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGA
GGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCC
AGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCA
ACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAG
GGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCC
CCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAG
AACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTG
GAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCT
CCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAG
ACACTCCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTG

>In-frame_ENST00000357214_ENST00000315869_TCGA-SX-A7SO_SFPQ_chr1_35654603_-_TFE3_chrX_48898095_length(amino acids)=1106AA_start in transcript=87_stop in transcript=3407
MTTDMSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQ
PPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPT
TPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGG
RSEEKISDSEGFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGFGFIKLESRALAEIAKAELDDTP
MRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFSQFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVI
VEPLEQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLR
QDLMRRQEELRRMEELHNQEMQKRKEMQLSLNSLLPESGIVADIELENVLDPDSFYELKSQPLPLRSSLPISLQATPATPATLSASSSAG
GSRTPAMSSSSSSRVLLRQQLMRAQAQEQERRERREQAAAAPFPSPAPASPAISVVGVSAGGHTLSRPPPAQVPREVLKVQTHLENPTRY
HLQQARRQQVKQYLSTTLGPKLASQALTPPPGPASAQPLPAPEAAHTTGPTGSAPNSPMALLTIGSSSEKEIDDVIDEIISLESSYNDEM
LSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKEL
GTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSL
KPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASD

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Fusion Gene PPI Analysis for SFPQ-TFE3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SFPQ-TFE3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SFPQ-TFE3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFPQC4518356MiT family translocation renal cell carcinoma2ORPHANET
HgeneSFPQC0019693HIV Infections1CTD_human
HgeneSFPQC0037274Dermatologic disorders1CTD_human
HgeneSFPQC0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneSFPQC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneSFPQC0311375Arsenic Poisoning1CTD_human
HgeneSFPQC0751851Arsenic Encephalopathy1CTD_human
HgeneSFPQC0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneSFPQC4505456HIV Coinfection1CTD_human
TgeneTFE3C4518356MiT family translocation renal cell carcinoma2ORPHANET
TgeneTFE3C0206657Alveolar Soft Part Sarcoma1ORPHANET
TgeneTFE3C0206732Epithelioid hemangioendothelioma1ORPHANET