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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SFSWAP-TRIM27 (FusionGDB2 ID:80581)

Fusion Gene Summary for SFSWAP-TRIM27

check button Fusion gene summary
Fusion gene informationFusion gene name: SFSWAP-TRIM27
Fusion gene ID: 80581
HgeneTgene
Gene symbol

SFSWAP

TRIM27

Gene ID

6433

5987

Gene namesplicing factor SWAPtripartite motif containing 27
SynonymsSFRS8|SWAPRFP|RNF76
Cytomap

12q24.33

6p22.1

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor, suppressor of white-apricot homologsplicing factor SWAP homologsplicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot homolog, Drosophila)splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot, Drosophila hozinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27
Modification date2020031320200327
UniProtAcc.

P14373

Ensembl transtripts involved in fusion geneENST00000261674, ENST00000541286, 
ENST00000539506, 		ENST00000377194, 
ENST00000377199, ENST00000498117, 
ENST00000459807, ENST00000412687, 
ENST00000437160, ENST00000427689, 
ENST00000435528, ENST00000485666, 
ENST00000468364, ENST00000455861, 
ENST00000417660, ENST00000400720, 
ENST00000495323, ENST00000491158, 
ENST00000437415, ENST00000468047, 
ENST00000431123, ENST00000452265, 
Fusion gene scores* DoF score7 X 7 X 5=2454 X 4 X 2=32
# samples 84
** MAII scorelog2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SFSWAP [Title/Abstract] AND TRIM27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSFSWAP(132272886)-TRIM27(28891278), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRIM27

GO:0000122

negative regulation of transcription by RNA polymerase II

10976108

TgeneTRIM27

GO:0006469

negative regulation of protein kinase activity

22128329

TgeneTRIM27

GO:0032897

negative regulation of viral transcription

18248090

TgeneTRIM27

GO:0034314

Arp2/3 complex-mediated actin nucleation

23452853

TgeneTRIM27

GO:0042147

retrograde transport, endosome to Golgi

23452853

TgeneTRIM27

GO:0045087

innate immune response

18248090

TgeneTRIM27

GO:0045814

negative regulation of gene expression, epigenetic

10976108

TgeneTRIM27

GO:0051091

positive regulation of DNA-binding transcription factor activity

23077300


check buttonFusion gene breakpoints across SFSWAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TRIM27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AEC581207SFSWAPchr12

132272886

-TRIM27chr6

28891278

-


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Fusion Gene ORF analysis for SFSWAP-TRIM27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000261674ENST00000377194SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-3CDSENST00000261674ENST00000377199SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000498117SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000459807SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000412687SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000437160SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000427689SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000435528SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000485666SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000468364SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000455861SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000417660SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000400720SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000495323SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000491158SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000437415SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000468047SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000431123SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000261674ENST00000452265SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-3CDSENST00000541286ENST00000377194SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-3CDSENST00000541286ENST00000377199SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000498117SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000459807SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000412687SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000437160SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000427689SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000435528SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000485666SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000468364SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000455861SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000417660SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000400720SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000495323SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000491158SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000437415SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000468047SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000431123SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000541286ENST00000452265SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-3CDSENST00000539506ENST00000377194SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-3CDSENST00000539506ENST00000377199SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000498117SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000459807SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000412687SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000437160SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000427689SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000435528SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000485666SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000468364SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000455861SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000417660SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000400720SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000495323SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000491158SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000437415SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000468047SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000431123SFSWAPchr12

132272886

-TRIM27chr6

28891278

-
intron-intronENST00000539506ENST00000452265SFSWAPchr12

132272886

-TRIM27chr6

28891278

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SFSWAP-TRIM27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SFSWAP-TRIM27


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TRIM27

P14373

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269|PubMed:10976108, ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329, ECO:0000269|PubMed:23452853}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SFSWAP-TRIM27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SFSWAP-TRIM27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SFSWAP-TRIM27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SFSWAP-TRIM27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFSWAPC1510586Autism Spectrum Disorders1CTD_human
TgeneTRIM27C0238463Papillary thyroid carcinoma2ORPHANET