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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SH3TC1-FNBP1 (FusionGDB2 ID:80959)

Fusion Gene Summary for SH3TC1-FNBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3TC1-FNBP1
Fusion gene ID: 80959
HgeneTgene
Gene symbol

SH3TC1

FNBP1

Gene ID

54436

23048

Gene nameSH3 domain and tetratricopeptide repeats 1formin binding protein 1
Synonyms-FBP17
Cytomap

4p16.1

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain and tetratricopeptide repeat-containing protein 1SH3 domain and tetratricopeptide repeats-containing protein 1formin-binding protein 1formin-binding protein 17
Modification date2020031320200313
UniProtAcc.

Q5T0N5

Ensembl transtripts involved in fusion geneENST00000382521, ENST00000245105, 
ENST00000539824, ENST00000514274, 
ENST00000446176, ENST00000420781, 
ENST00000355681, ENST00000443566, 
ENST00000478129, 
Fusion gene scores* DoF score2 X 2 X 2=824 X 24 X 8=4608
# samples 226
** MAII scorelog2(2/8*10)=1.32192809488736log2(26/4608*10)=-4.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3TC1 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSH3TC1(8216307)-FNBP1(132658275), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SH3TC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FNBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5798-01ASH3TC1chr4

8216307

+FNBP1chr9

132658275

-


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Fusion Gene ORF analysis for SH3TC1-FNBP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000382521ENST00000446176SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000382521ENST00000420781SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000382521ENST00000355681SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000382521ENST00000443566SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-intronENST00000382521ENST00000478129SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000245105ENST00000446176SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000245105ENST00000420781SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000245105ENST00000355681SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000245105ENST00000443566SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
5CDS-intronENST00000245105ENST00000478129SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000539824ENST00000446176SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000539824ENST00000420781SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000539824ENST00000355681SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
In-frameENST00000539824ENST00000443566SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
5CDS-intronENST00000539824ENST00000478129SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000514274ENST00000446176SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000514274ENST00000420781SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000514274ENST00000355681SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-3CDSENST00000514274ENST00000443566SH3TC1chr4

8216307

+FNBP1chr9

132658275

-
intron-intronENST00000514274ENST00000478129SH3TC1chr4

8216307

+FNBP1chr9

132658275

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245105SH3TC1chr48216307+ENST00000446176FNBP1chr9132658275-406754858714218
ENST00000245105SH3TC1chr48216307+ENST00000420781FNBP1chr9132658275-406754858714218
ENST00000245105SH3TC1chr48216307+ENST00000355681FNBP1chr9132658275-73354858726222
ENST00000245105SH3TC1chr48216307+ENST00000443566FNBP1chr9132658275-86954858714218
ENST00000539824SH3TC1chr48216307+ENST00000446176FNBP1chr9132658275-414662713461984212
ENST00000539824SH3TC1chr48216307+ENST00000420781FNBP1chr9132658275-414662713461984212
ENST00000539824SH3TC1chr48216307+ENST00000355681FNBP1chr9132658275-812627188805205
ENST00000539824SH3TC1chr48216307+ENST00000443566FNBP1chr9132658275-948627188793201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245105ENST00000446176SH3TC1chr48216307+FNBP1chr9132658275-0.0066145090.9933855
ENST00000245105ENST00000420781SH3TC1chr48216307+FNBP1chr9132658275-0.0066145090.9933855
ENST00000245105ENST00000355681SH3TC1chr48216307+FNBP1chr9132658275-0.0077340890.9922659
ENST00000245105ENST00000443566SH3TC1chr48216307+FNBP1chr9132658275-0.0115119850.988488
ENST00000539824ENST00000446176SH3TC1chr48216307+FNBP1chr9132658275-0.621085940.378914
ENST00000539824ENST00000420781SH3TC1chr48216307+FNBP1chr9132658275-0.621085940.378914
ENST00000539824ENST00000355681SH3TC1chr48216307+FNBP1chr9132658275-0.0119951040.98800486
ENST00000539824ENST00000443566SH3TC1chr48216307+FNBP1chr9132658275-0.0152684390.98473155

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Fusion Genomic Features for SH3TC1-FNBP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SH3TC1-FNBP1


check button Go to

FGviewer for the breakpoints of chr4:8216307-chr9:132658275

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FNBP1

Q5T0N5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416550_611533.3333333333334593.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518305_368160.333333333333341337.0DomainSH3
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181027_1063160.333333333333341337.0RepeatNote=TPR 7
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181192_1225160.333333333333341337.0RepeatNote=TPR 8
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181277_1311160.333333333333341337.0RepeatNote=TPR 9
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518560_593160.333333333333341337.0RepeatNote=TPR 1
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518601_634160.333333333333341337.0RepeatNote=TPR 2
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518665_698160.333333333333341337.0RepeatNote=TPR 3
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518786_819160.333333333333341337.0RepeatNote=TPR 4
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518863_896160.333333333333341337.0RepeatNote=TPR 5
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518946_979160.333333333333341337.0RepeatNote=TPR 6
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416398_490533.3333333333334593.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr4:8216307chr9:132658275ENST00000355681141667_259533.3333333333334593.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417398_490562.3333333333334618.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr4:8216307chr9:132658275ENST00000446176141767_259562.3333333333334618.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416340_345533.3333333333334593.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417340_345562.3333333333334618.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_264533.3333333333334593.0DomainF-BAR
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416404_481533.3333333333334593.0DomainREM-1
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_264562.3333333333334618.0DomainF-BAR
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417404_481562.3333333333334618.0DomainREM-1
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417550_611562.3333333333334618.0DomainSH3
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_79533.3333333333334593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416251_617533.3333333333334593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_79562.3333333333334618.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417251_617562.3333333333334618.0RegionNote=Required for self-association and induction of membrane tubulation


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Fusion Gene Sequence for SH3TC1-FNBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000245105_ENST00000446176_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=4067nt_BP=548nt
CTGTGGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGAC
CACTGAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAG
GCCCTCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCC
TGCTGCTGGGACCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCG
GGACCCCGGCCTACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATC
AGCCAGGCTGCTGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCA
TGCTCTCGGTCAGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCG
CATTCGGAGAAATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGG
AGTGCCTGCGAGCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCC
ACCCCTCCGCAGCCCCATCCCTGCGGGGCGGTCTCTCTCTCTCTCCAGCATGCTCCCTGCGGCCCTGCCCTCCCGCCCAGCCCGGGCCAC
CTCGTGGGGGACAAGTCTCGCCAGCGCCCACCCCCATGGCTCGGGTCAGTCCTCATCGCTCCCCCTCCCCACCCCGCGCAGGCCACTGAG
ACGGTGGGACACACGCCCCTACCTGCTCCTTCCTGGGCCCTCAGTCCACCCGGGCTCGTCCTGGCAGCCCTTCCGCGCTTCACACAGTGC
CTTTTGTGAAAGTGTCATCACGGGTCCCCTGAGGAGACAAGGCAGGTCCAGCGCACATCAGGCGGACTGAGCACTCGATGTCATCCGTGT
CGATGTCATCCGTGTGTCCCAGACTGTCTGCTGTAGAAAACACTTCCTCCTCTCCTGAGTCTGTGAAGTCCTCAGTGGTCCTTTTTGGAT
TCTAGGCTTGCACCTCATACTAAACATTGACCCTTTCACTATGCCCTCAACCTGGGAGCATCTGGCAGGCAGGGGGGCAGGTACACACAC
ACCCACAGGCACACCCACCAGTACACACGCGTGCGCATACACACATTTTGGTTTGACGCCCTGTTTTCAGTGGCCTGGGGAGGTCCACAC
TGGAAGTCGAATTCCAGCTCGCCTTGTTGACTCGCCTGTGTCCACCGGCCATGAGGAGCCCACGCCTGTCCTCCCCATCACTTTCCTGTC
CCTGAGAACTGTAGATCATGCGCTTGTGAGCGAGGCCCTCCCCTCTGCACCAGCTCATTGCAAAGCGAACATCCTCTCCTTTCCAGGAGC
CCCAGGATTAGCATCTGAAAAGGGTAGCACTTCCTTTTTTGTTGTTGTTTTTTTTTTTTTTTTGAGACGGGAGTCTCGCTCTATTGTTCA
GACTGGAGTGCAGTGGCATGATCTCGGCTCACTACAACCTCCACCTCCTGGGTTCCAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTG
TGATTACAGGCGTGCACCACCACGCCCGGCTAATGTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGTCAGGCTGGTCTCAAAC
TCCTGACCTCAGGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCTACCGCACCCCGCCGAGGTTAGCACTTT
CATCACCAAAGACCCCGTGCCTCTCGTGGTCCTTTGAGGGATCCCGCCGCCACCACCCTTGTATTTTATCACGTGCTCTTCAGGGCATGT
GGAATTCGTTGAGTTTGCTTTTAGAGCCAAGTTTCTTTCCCTGTGTGGGTTTTTGAGGAAAACCTGAGGTCCCCTAATCTGTGGCCACCA
CCCCCCCCCCCCGCCACGCCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCCTAGAGCTCC
TGTGACCGAGAGCGCCACGGAAGCCTGGGGATGACGTCGGGCAGCTTTATTCTTTGCTTGGCTTTGGTAACTAGGTGGTCCCCTCAAGCA
TCCTCAGTTCCTCTTGCTGTTTATGAATCTAAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAGGGACGGAAAGGACAGGTCCCAAGGG
ATGGGGCTGTCTTTACTTGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAAGGTTGACCACACACCACCCTTCCGGAGCAGCTCAGT
CAGCCCTCGGGGACGAGAAACCACAAGCGCAGAGACGCTGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTTGGGTTTTTAAAGTAGGTGA
GCGTGAGCCTCTCTGACTGCTTCTTCCCCGGGGGGGACTGCAAACCGCTCAGGGTTGCGGCAGAGCCATGGACTTCCGGTCCCTGCAACG
GGTGACCTAAGCGTGGTGCACCCATCAGTCACGCAGGAGGACTGACTTGACAGACGAAAGACAAGCCCGGATGACACAGGGTGAGAAGAG
TCAGGGCCGCACCTCTGTCCCTGCAAACCAACAGGTGCATGGTGAGTGTGGCAGTCCCCACAGCTCCACAATGGGCTCCCCCGCCAACGG
GGACGACAGGGATCTTCAGGAACTTCTGACCTCACCAAGTCAAGTGGACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAAT
GGGATTTTAGAGCCTCGGGAATGCATGTGCGTCACATCTTTCATATTATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGGAAAAGA
TATAAGCTGCAGTAATTTGCTCTTTGAATGACCGTCACCCCCAGTATAGGATATGCTTGTATCCCCCCGTCACTCCTCCGCCTGTTTTTT
AAACTTTTCCACCACCTGCGTCCAAAAAGAATGTTATAGCGAGTGCTCTTAAATGTTGAACCTGGGTGTTGCTTCCGGGCCAGTCTGCGT
GGCTCCATGAAAAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATCATTTACTCTGGGAATCCTAC
TGTGAAATCATGTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAATGTGGAATTTCCCGTGAACGTCTCCTTCCTCCCCCGTATCTG
CCGCCTGTCACTTCGCCACCGTGCTAGAATACTGTTGTGTTGTAAGATGACTAATTTTAAAAGAACCTGCCCTGAAAAGTTCTTAGAAAC
GCAGTGAAAGGGAGGAACTTGTCCTTTACCCAGTTTTTCCTTTGTAGGATGGGAAAGTATAAAAAGGCACAGAAGGTTGTCATGGGCTGT
TCCTTGGGGGTTTTTATCCTGCTCACCGTGGAGATAAGCCTGCGGCTTGTCTAACCAGCGCAGCGCAAAGGTCTCGATGCCTTTTGGTAA
CATCCGTCATTGCAGAAGAAAGTTTACACGACGTCAAAAAGTGACGTTCATGCTAAGTGTTTTTCCAGAAATATTGGTTTCATGTTTCTT
ATTGGCTCTGCCTCCTGTGCTTATATCATCCAAAAACTTTTTAAAAAGGTCCAGAATTCTATTTTAACCTGATGTTGAGCACCTTTAAAA
TGTTCGTATGTGTGTTGCACTAATTCTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCGATCGCCACTGTAAAGGTCCTAGAGTTGCCTG
TTTGTCTCTGGAGATGGAATTAAACCAAATAAAGAGCTTCCACTGGAGGCTTGTATTGACCTTGTAACTATATGTTAATCTCGTGTTAAA

>In-frame_ENST00000245105_ENST00000446176_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=218AA_start in transcript=58_stop in transcript=714
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------
>In-frame_ENST00000245105_ENST00000420781_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=4067nt_BP=548nt
CTGTGGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGAC
CACTGAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAG
GCCCTCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCC
TGCTGCTGGGACCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCG
GGACCCCGGCCTACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATC
AGCCAGGCTGCTGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCA
TGCTCTCGGTCAGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCG
CATTCGGAGAAATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGG
AGTGCCTGCGAGCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCC
ACCCCTCCGCAGCCCCATCCCTGCGGGGCGGTCTCTCTCTCTCTCCAGCATGCTCCCTGCGGCCCTGCCCTCCCGCCCAGCCCGGGCCAC
CTCGTGGGGGACAAGTCTCGCCAGCGCCCACCCCCATGGCTCGGGTCAGTCCTCATCGCTCCCCCTCCCCACCCCGCGCAGGCCACTGAG
ACGGTGGGACACACGCCCCTACCTGCTCCTTCCTGGGCCCTCAGTCCACCCGGGCTCGTCCTGGCAGCCCTTCCGCGCTTCACACAGTGC
CTTTTGTGAAAGTGTCATCACGGGTCCCCTGAGGAGACAAGGCAGGTCCAGCGCACATCAGGCGGACTGAGCACTCGATGTCATCCGTGT
CGATGTCATCCGTGTGTCCCAGACTGTCTGCTGTAGAAAACACTTCCTCCTCTCCTGAGTCTGTGAAGTCCTCAGTGGTCCTTTTTGGAT
TCTAGGCTTGCACCTCATACTAAACATTGACCCTTTCACTATGCCCTCAACCTGGGAGCATCTGGCAGGCAGGGGGGCAGGTACACACAC
ACCCACAGGCACACCCACCAGTACACACGCGTGCGCATACACACATTTTGGTTTGACGCCCTGTTTTCAGTGGCCTGGGGAGGTCCACAC
TGGAAGTCGAATTCCAGCTCGCCTTGTTGACTCGCCTGTGTCCACCGGCCATGAGGAGCCCACGCCTGTCCTCCCCATCACTTTCCTGTC
CCTGAGAACTGTAGATCATGCGCTTGTGAGCGAGGCCCTCCCCTCTGCACCAGCTCATTGCAAAGCGAACATCCTCTCCTTTCCAGGAGC
CCCAGGATTAGCATCTGAAAAGGGTAGCACTTCCTTTTTTGTTGTTGTTTTTTTTTTTTTTTTGAGACGGGAGTCTCGCTCTATTGTTCA
GACTGGAGTGCAGTGGCATGATCTCGGCTCACTACAACCTCCACCTCCTGGGTTCCAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTG
TGATTACAGGCGTGCACCACCACGCCCGGCTAATGTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGTCAGGCTGGTCTCAAAC
TCCTGACCTCAGGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCTACCGCACCCCGCCGAGGTTAGCACTTT
CATCACCAAAGACCCCGTGCCTCTCGTGGTCCTTTGAGGGATCCCGCCGCCACCACCCTTGTATTTTATCACGTGCTCTTCAGGGCATGT
GGAATTCGTTGAGTTTGCTTTTAGAGCCAAGTTTCTTTCCCTGTGTGGGTTTTTGAGGAAAACCTGAGGTCCCCTAATCTGTGGCCACCA
CCCCCCCCCCCCGCCACGCCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCCTAGAGCTCC
TGTGACCGAGAGCGCCACGGAAGCCTGGGGATGACGTCGGGCAGCTTTATTCTTTGCTTGGCTTTGGTAACTAGGTGGTCCCCTCAAGCA
TCCTCAGTTCCTCTTGCTGTTTATGAATCTAAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAGGGACGGAAAGGACAGGTCCCAAGGG
ATGGGGCTGTCTTTACTTGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAAGGTTGACCACACACCACCCTTCCGGAGCAGCTCAGT
CAGCCCTCGGGGACGAGAAACCACAAGCGCAGAGACGCTGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTTGGGTTTTTAAAGTAGGTGA
GCGTGAGCCTCTCTGACTGCTTCTTCCCCGGGGGGGACTGCAAACCGCTCAGGGTTGCGGCAGAGCCATGGACTTCCGGTCCCTGCAACG
GGTGACCTAAGCGTGGTGCACCCATCAGTCACGCAGGAGGACTGACTTGACAGACGAAAGACAAGCCCGGATGACACAGGGTGAGAAGAG
TCAGGGCCGCACCTCTGTCCCTGCAAACCAACAGGTGCATGGTGAGTGTGGCAGTCCCCACAGCTCCACAATGGGCTCCCCCGCCAACGG
GGACGACAGGGATCTTCAGGAACTTCTGACCTCACCAAGTCAAGTGGACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAAT
GGGATTTTAGAGCCTCGGGAATGCATGTGCGTCACATCTTTCATATTATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGGAAAAGA
TATAAGCTGCAGTAATTTGCTCTTTGAATGACCGTCACCCCCAGTATAGGATATGCTTGTATCCCCCCGTCACTCCTCCGCCTGTTTTTT
AAACTTTTCCACCACCTGCGTCCAAAAAGAATGTTATAGCGAGTGCTCTTAAATGTTGAACCTGGGTGTTGCTTCCGGGCCAGTCTGCGT
GGCTCCATGAAAAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATCATTTACTCTGGGAATCCTAC
TGTGAAATCATGTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAATGTGGAATTTCCCGTGAACGTCTCCTTCCTCCCCCGTATCTG
CCGCCTGTCACTTCGCCACCGTGCTAGAATACTGTTGTGTTGTAAGATGACTAATTTTAAAAGAACCTGCCCTGAAAAGTTCTTAGAAAC
GCAGTGAAAGGGAGGAACTTGTCCTTTACCCAGTTTTTCCTTTGTAGGATGGGAAAGTATAAAAAGGCACAGAAGGTTGTCATGGGCTGT
TCCTTGGGGGTTTTTATCCTGCTCACCGTGGAGATAAGCCTGCGGCTTGTCTAACCAGCGCAGCGCAAAGGTCTCGATGCCTTTTGGTAA
CATCCGTCATTGCAGAAGAAAGTTTACACGACGTCAAAAAGTGACGTTCATGCTAAGTGTTTTTCCAGAAATATTGGTTTCATGTTTCTT
ATTGGCTCTGCCTCCTGTGCTTATATCATCCAAAAACTTTTTAAAAAGGTCCAGAATTCTATTTTAACCTGATGTTGAGCACCTTTAAAA
TGTTCGTATGTGTGTTGCACTAATTCTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCGATCGCCACTGTAAAGGTCCTAGAGTTGCCTG
TTTGTCTCTGGAGATGGAATTAAACCAAATAAAGAGCTTCCACTGGAGGCTTGTATTGACCTTGTAACTATATGTTAATCTCGTGTTAAA

>In-frame_ENST00000245105_ENST00000420781_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=218AA_start in transcript=58_stop in transcript=714
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------
>In-frame_ENST00000245105_ENST00000355681_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=733nt_BP=548nt
CTGTGGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGAC
CACTGAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAG
GCCCTCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCC
TGCTGCTGGGACCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCG
GGACCCCGGCCTACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATC
AGCCAGGCTGCTGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCA
TGCTCTCGGTCAGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCG
CATTCGGAGAAATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGGTGCTAAGACTTA

>In-frame_ENST00000245105_ENST00000355681_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=222AA_start in transcript=58_stop in transcript=726
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------
>In-frame_ENST00000245105_ENST00000443566_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=869nt_BP=548nt
CTGTGGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGAC
CACTGAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAG
GCCCTCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCC
TGCTGCTGGGACCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCG
GGACCCCGGCCTACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATC
AGCCAGGCTGCTGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCA
TGCTCTCGGTCAGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCG
CATTCGGAGAAATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGG
AGTGCCTGCGAGCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCC

>In-frame_ENST00000245105_ENST00000443566_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=218AA_start in transcript=58_stop in transcript=714
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------
>In-frame_ENST00000539824_ENST00000446176_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=4146nt_BP=627nt
GGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGACCACT
GAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAGGCCC
TCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGAGAGACCTGGAGCGTTTGGCGCCTTCAGAGGAGCC
AGGCCTTTGCTTGGTCTCCCCTAATCCTGGGAACCTGCTGTGTTGCAGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCCTGCTGCTGGGA
CCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCGGGACCCCGGCC
TACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATCAGCCAGGCTGC
TGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCATGCTCTCGGTC
AGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCGCATTCGGAGAA
ATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGGAGTGCCTGCGA
GCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCCACCCCTCCGCA
GCCCCATCCCTGCGGGGCGGTCTCTCTCTCTCTCCAGCATGCTCCCTGCGGCCCTGCCCTCCCGCCCAGCCCGGGCCACCTCGTGGGGGA
CAAGTCTCGCCAGCGCCCACCCCCATGGCTCGGGTCAGTCCTCATCGCTCCCCCTCCCCACCCCGCGCAGGCCACTGAGACGGTGGGACA
CACGCCCCTACCTGCTCCTTCCTGGGCCCTCAGTCCACCCGGGCTCGTCCTGGCAGCCCTTCCGCGCTTCACACAGTGCCTTTTGTGAAA
GTGTCATCACGGGTCCCCTGAGGAGACAAGGCAGGTCCAGCGCACATCAGGCGGACTGAGCACTCGATGTCATCCGTGTCGATGTCATCC
GTGTGTCCCAGACTGTCTGCTGTAGAAAACACTTCCTCCTCTCCTGAGTCTGTGAAGTCCTCAGTGGTCCTTTTTGGATTCTAGGCTTGC
ACCTCATACTAAACATTGACCCTTTCACTATGCCCTCAACCTGGGAGCATCTGGCAGGCAGGGGGGCAGGTACACACACACCCACAGGCA
CACCCACCAGTACACACGCGTGCGCATACACACATTTTGGTTTGACGCCCTGTTTTCAGTGGCCTGGGGAGGTCCACACTGGAAGTCGAA
TTCCAGCTCGCCTTGTTGACTCGCCTGTGTCCACCGGCCATGAGGAGCCCACGCCTGTCCTCCCCATCACTTTCCTGTCCCTGAGAACTG
TAGATCATGCGCTTGTGAGCGAGGCCCTCCCCTCTGCACCAGCTCATTGCAAAGCGAACATCCTCTCCTTTCCAGGAGCCCCAGGATTAG
CATCTGAAAAGGGTAGCACTTCCTTTTTTGTTGTTGTTTTTTTTTTTTTTTTGAGACGGGAGTCTCGCTCTATTGTTCAGACTGGAGTGC
AGTGGCATGATCTCGGCTCACTACAACCTCCACCTCCTGGGTTCCAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTGTGATTACAGGC
GTGCACCACCACGCCCGGCTAATGTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCA
GGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCTACCGCACCCCGCCGAGGTTAGCACTTTCATCACCAAAG
ACCCCGTGCCTCTCGTGGTCCTTTGAGGGATCCCGCCGCCACCACCCTTGTATTTTATCACGTGCTCTTCAGGGCATGTGGAATTCGTTG
AGTTTGCTTTTAGAGCCAAGTTTCTTTCCCTGTGTGGGTTTTTGAGGAAAACCTGAGGTCCCCTAATCTGTGGCCACCACCCCCCCCCCC
CGCCACGCCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCCTAGAGCTCCTGTGACCGAGA
GCGCCACGGAAGCCTGGGGATGACGTCGGGCAGCTTTATTCTTTGCTTGGCTTTGGTAACTAGGTGGTCCCCTCAAGCATCCTCAGTTCC
TCTTGCTGTTTATGAATCTAAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAGGGACGGAAAGGACAGGTCCCAAGGGATGGGGCTGTC
TTTACTTGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAAGGTTGACCACACACCACCCTTCCGGAGCAGCTCAGTCAGCCCTCGGG
GACGAGAAACCACAAGCGCAGAGACGCTGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTTGGGTTTTTAAAGTAGGTGAGCGTGAGCCTC
TCTGACTGCTTCTTCCCCGGGGGGGACTGCAAACCGCTCAGGGTTGCGGCAGAGCCATGGACTTCCGGTCCCTGCAACGGGTGACCTAAG
CGTGGTGCACCCATCAGTCACGCAGGAGGACTGACTTGACAGACGAAAGACAAGCCCGGATGACACAGGGTGAGAAGAGTCAGGGCCGCA
CCTCTGTCCCTGCAAACCAACAGGTGCATGGTGAGTGTGGCAGTCCCCACAGCTCCACAATGGGCTCCCCCGCCAACGGGGACGACAGGG
ATCTTCAGGAACTTCTGACCTCACCAAGTCAAGTGGACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAATGGGATTTTAGA
GCCTCGGGAATGCATGTGCGTCACATCTTTCATATTATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGGAAAAGATATAAGCTGCA
GTAATTTGCTCTTTGAATGACCGTCACCCCCAGTATAGGATATGCTTGTATCCCCCCGTCACTCCTCCGCCTGTTTTTTAAACTTTTCCA
CCACCTGCGTCCAAAAAGAATGTTATAGCGAGTGCTCTTAAATGTTGAACCTGGGTGTTGCTTCCGGGCCAGTCTGCGTGGCTCCATGAA
AAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATCATTTACTCTGGGAATCCTACTGTGAAATCAT
GTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAATGTGGAATTTCCCGTGAACGTCTCCTTCCTCCCCCGTATCTGCCGCCTGTCAC
TTCGCCACCGTGCTAGAATACTGTTGTGTTGTAAGATGACTAATTTTAAAAGAACCTGCCCTGAAAAGTTCTTAGAAACGCAGTGAAAGG
GAGGAACTTGTCCTTTACCCAGTTTTTCCTTTGTAGGATGGGAAAGTATAAAAAGGCACAGAAGGTTGTCATGGGCTGTTCCTTGGGGGT
TTTTATCCTGCTCACCGTGGAGATAAGCCTGCGGCTTGTCTAACCAGCGCAGCGCAAAGGTCTCGATGCCTTTTGGTAACATCCGTCATT
GCAGAAGAAAGTTTACACGACGTCAAAAAGTGACGTTCATGCTAAGTGTTTTTCCAGAAATATTGGTTTCATGTTTCTTATTGGCTCTGC
CTCCTGTGCTTATATCATCCAAAAACTTTTTAAAAAGGTCCAGAATTCTATTTTAACCTGATGTTGAGCACCTTTAAAATGTTCGTATGT
GTGTTGCACTAATTCTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCGATCGCCACTGTAAAGGTCCTAGAGTTGCCTGTTTGTCTCTGG
AGATGGAATTAAACCAAATAAAGAGCTTCCACTGGAGGCTTGTATTGACCTTGTAACTATATGTTAATCTCGTGTTAAAATAAAATATAA

>In-frame_ENST00000539824_ENST00000446176_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=212AA_start in transcript=1346_stop in transcript=1984
MHLILNIDPFTMPSTWEHLAGRGAGTHTPTGTPTSTHACAYTHFGLTPCFQWPGEVHTGSRIPARLVDSPVSTGHEEPTPVLPITFLSLR
TVDHALVSEALPSAPAHCKANILSFPGAPGLASEKGSTSFFVVVFFFFLRRESRSIVQTGVQWHDLGSLQPPPPGFQRFSCLSLPNSCDY

--------------------------------------------------------------
>In-frame_ENST00000539824_ENST00000420781_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=4146nt_BP=627nt
GGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGACCACT
GAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAGGCCC
TCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGAGAGACCTGGAGCGTTTGGCGCCTTCAGAGGAGCC
AGGCCTTTGCTTGGTCTCCCCTAATCCTGGGAACCTGCTGTGTTGCAGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCCTGCTGCTGGGA
CCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCGGGACCCCGGCC
TACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATCAGCCAGGCTGC
TGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCATGCTCTCGGTC
AGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCGCATTCGGAGAA
ATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGGAGTGCCTGCGA
GCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCCACCCCTCCGCA
GCCCCATCCCTGCGGGGCGGTCTCTCTCTCTCTCCAGCATGCTCCCTGCGGCCCTGCCCTCCCGCCCAGCCCGGGCCACCTCGTGGGGGA
CAAGTCTCGCCAGCGCCCACCCCCATGGCTCGGGTCAGTCCTCATCGCTCCCCCTCCCCACCCCGCGCAGGCCACTGAGACGGTGGGACA
CACGCCCCTACCTGCTCCTTCCTGGGCCCTCAGTCCACCCGGGCTCGTCCTGGCAGCCCTTCCGCGCTTCACACAGTGCCTTTTGTGAAA
GTGTCATCACGGGTCCCCTGAGGAGACAAGGCAGGTCCAGCGCACATCAGGCGGACTGAGCACTCGATGTCATCCGTGTCGATGTCATCC
GTGTGTCCCAGACTGTCTGCTGTAGAAAACACTTCCTCCTCTCCTGAGTCTGTGAAGTCCTCAGTGGTCCTTTTTGGATTCTAGGCTTGC
ACCTCATACTAAACATTGACCCTTTCACTATGCCCTCAACCTGGGAGCATCTGGCAGGCAGGGGGGCAGGTACACACACACCCACAGGCA
CACCCACCAGTACACACGCGTGCGCATACACACATTTTGGTTTGACGCCCTGTTTTCAGTGGCCTGGGGAGGTCCACACTGGAAGTCGAA
TTCCAGCTCGCCTTGTTGACTCGCCTGTGTCCACCGGCCATGAGGAGCCCACGCCTGTCCTCCCCATCACTTTCCTGTCCCTGAGAACTG
TAGATCATGCGCTTGTGAGCGAGGCCCTCCCCTCTGCACCAGCTCATTGCAAAGCGAACATCCTCTCCTTTCCAGGAGCCCCAGGATTAG
CATCTGAAAAGGGTAGCACTTCCTTTTTTGTTGTTGTTTTTTTTTTTTTTTTGAGACGGGAGTCTCGCTCTATTGTTCAGACTGGAGTGC
AGTGGCATGATCTCGGCTCACTACAACCTCCACCTCCTGGGTTCCAGCGATTCTCCTGCCTCAGCCTCCCAAATAGCTGTGATTACAGGC
GTGCACCACCACGCCCGGCTAATGTTTGTATTTTTAGTAGAGACAGGGTTTCACCGTGTTGGTCAGGCTGGTCTCAAACTCCTGACCTCA
GGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCTACCGCACCCCGCCGAGGTTAGCACTTTCATCACCAAAG
ACCCCGTGCCTCTCGTGGTCCTTTGAGGGATCCCGCCGCCACCACCCTTGTATTTTATCACGTGCTCTTCAGGGCATGTGGAATTCGTTG
AGTTTGCTTTTAGAGCCAAGTTTCTTTCCCTGTGTGGGTTTTTGAGGAAAACCTGAGGTCCCCTAATCTGTGGCCACCACCCCCCCCCCC
CGCCACGCCTTAGAGCAGAGCAGCCCCTCCTCTCATTTGGTGCAGAAACAGTCAAGAGGAACCATTGGCCTAGAGCTCCTGTGACCGAGA
GCGCCACGGAAGCCTGGGGATGACGTCGGGCAGCTTTATTCTTTGCTTGGCTTTGGTAACTAGGTGGTCCCCTCAAGCATCCTCAGTTCC
TCTTGCTGTTTATGAATCTAAGACAAGGAAGTCCTATAGAAGCCAAAGGGACAGGGACGGAAAGGACAGGTCCCAAGGGATGGGGCTGTC
TTTACTTGTGGAAACCAGGAAATTGCTCCTCTCAGCCAACCAAGGTTGACCACACACCACCCTTCCGGAGCAGCTCAGTCAGCCCTCGGG
GACGAGAAACCACAAGCGCAGAGACGCTGAGGCCCAGGCAGGTGAAGAGGAAGTGGCTTTGGGTTTTTAAAGTAGGTGAGCGTGAGCCTC
TCTGACTGCTTCTTCCCCGGGGGGGACTGCAAACCGCTCAGGGTTGCGGCAGAGCCATGGACTTCCGGTCCCTGCAACGGGTGACCTAAG
CGTGGTGCACCCATCAGTCACGCAGGAGGACTGACTTGACAGACGAAAGACAAGCCCGGATGACACAGGGTGAGAAGAGTCAGGGCCGCA
CCTCTGTCCCTGCAAACCAACAGGTGCATGGTGAGTGTGGCAGTCCCCACAGCTCCACAATGGGCTCCCCCGCCAACGGGGACGACAGGG
ATCTTCAGGAACTTCTGACCTCACCAAGTCAAGTGGACCACTCTCCACTCCACGAGGATGTGAAACGGTTCTTTAAAATGGGATTTTAGA
GCCTCGGGAATGCATGTGCGTCACATCTTTCATATTATGGGTCAGGATAGATTCATTTCTTGCAACATAGTGGAAAAGATATAAGCTGCA
GTAATTTGCTCTTTGAATGACCGTCACCCCCAGTATAGGATATGCTTGTATCCCCCCGTCACTCCTCCGCCTGTTTTTTAAACTTTTCCA
CCACCTGCGTCCAAAAAGAATGTTATAGCGAGTGCTCTTAAATGTTGAACCTGGGTGTTGCTTCCGGGCCAGTCTGCGTGGCTCCATGAA
AAGCTCACTGCTGCCCCAGCCGGGCTTCTTAGAGGAGGTCAGTTGTCCTATGTATCATCATTTACTCTGGGAATCCTACTGTGAAATCAT
GTCTGTATTTTTCTGGAGCAGTTCACATAGAGTAGAATGTGGAATTTCCCGTGAACGTCTCCTTCCTCCCCCGTATCTGCCGCCTGTCAC
TTCGCCACCGTGCTAGAATACTGTTGTGTTGTAAGATGACTAATTTTAAAAGAACCTGCCCTGAAAAGTTCTTAGAAACGCAGTGAAAGG
GAGGAACTTGTCCTTTACCCAGTTTTTCCTTTGTAGGATGGGAAAGTATAAAAAGGCACAGAAGGTTGTCATGGGCTGTTCCTTGGGGGT
TTTTATCCTGCTCACCGTGGAGATAAGCCTGCGGCTTGTCTAACCAGCGCAGCGCAAAGGTCTCGATGCCTTTTGGTAACATCCGTCATT
GCAGAAGAAAGTTTACACGACGTCAAAAAGTGACGTTCATGCTAAGTGTTTTTCCAGAAATATTGGTTTCATGTTTCTTATTGGCTCTGC
CTCCTGTGCTTATATCATCCAAAAACTTTTTAAAAAGGTCCAGAATTCTATTTTAACCTGATGTTGAGCACCTTTAAAATGTTCGTATGT
GTGTTGCACTAATTCTAAACTTTGGAGGCATTTTGCTGTGTGAGGCCGATCGCCACTGTAAAGGTCCTAGAGTTGCCTGTTTGTCTCTGG
AGATGGAATTAAACCAAATAAAGAGCTTCCACTGGAGGCTTGTATTGACCTTGTAACTATATGTTAATCTCGTGTTAAAATAAAATATAA

>In-frame_ENST00000539824_ENST00000420781_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=212AA_start in transcript=1346_stop in transcript=1984
MHLILNIDPFTMPSTWEHLAGRGAGTHTPTGTPTSTHACAYTHFGLTPCFQWPGEVHTGSRIPARLVDSPVSTGHEEPTPVLPITFLSLR
TVDHALVSEALPSAPAHCKANILSFPGAPGLASEKGSTSFFVVVFFFFLRRESRSIVQTGVQWHDLGSLQPPPPGFQRFSCLSLPNSCDY

--------------------------------------------------------------
>In-frame_ENST00000539824_ENST00000355681_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=812nt_BP=627nt
GGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGACCACT
GAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAGGCCC
TCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGAGAGACCTGGAGCGTTTGGCGCCTTCAGAGGAGCC
AGGCCTTTGCTTGGTCTCCCCTAATCCTGGGAACCTGCTGTGTTGCAGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCCTGCTGCTGGGA
CCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCGGGACCCCGGCC
TACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATCAGCCAGGCTGC
TGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCATGCTCTCGGTC
AGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCGCATTCGGAGAA
ATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGGTGCTAAGACTTATATTTAATACC

>In-frame_ENST00000539824_ENST00000355681_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=205AA_start in transcript=188_stop in transcript=805
MGESGARGGQGASERRETWSVWRLQRSQAFAWSPLILGTCCVADEAPPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQ
TLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNED

--------------------------------------------------------------
>In-frame_ENST00000539824_ENST00000443566_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(transcript)=948nt_BP=627nt
GGGCCTGGGAGCTGCCTCTGAGGAACACGCCGCAGGGCCAGGCATGTGAGGTCTCTGCGGGTCATGGAGAACCTCCCTGCCGTGACCACT
GAGGAGCCGACCCCCATGGGGAGGGGTCCTGTGGGACCCTCAGGAGGTGGCAGCACCCGGGACCAGGTCCGGACTGTGGTCATGAGGCCC
TCTGTGAGCTGGGAGAAAGCGGGGCCCGAGGAGGCCAAGGCGCCAGTGAGAGGCGAGAGACCTGGAGCGTTTGGCGCCTTCAGAGGAGCC
AGGCCTTTGCTTGGTCTCCCCTAATCCTGGGAACCTGCTGTGTTGCAGACGAGGCTCCTCCTGCCCGCGTGGCTGGGCCTGCTGCTGGGA
CCCCTCCCTGCCAGATGGGGGTTTATCCCACAGACCTGACCCTGCAGCTGCTGGCTGTGCGGAGGAAGAGCAGACTGCGGGACCCCGGCC
TACAGCAGACCCTCCGGGGCCAGCTCCGCCTGCTGGAGAATGATAGCCGGGAGATGGCCCGCGTGCTTGGGGAATTATCAGCCAGGCTGC
TGTCCATCCACAGTGACCAGGACCGGATCGTGGTGACGTTTAAGACTTTTGAAGAAATCTGGAAGTTTTCCACCTACCATGCTCTCGGTC
AGAATGAAGGAACGATTTCCGTAGTTGAAGGAGAAACATTGTATGTCATAGAGGAAGACAAAGGCGATGGCTGGACCCGCATTCGGAGAA
ATGAAGATGAAGAGGGTTATGTCCCCACTTCATATGTCGAAGTCTGTTTGGACAAAAATGCCAAAGATTCCTAGAGGGGAGTGCCTGCGA
GCCTCGGGTGAGCCTTCCTGGAGGAGCCTCCGTCTGCTTGTTCCCACAGGCCTCCAGCGCCCTGCCCTGTGGACAGCCCACCCCTCCGCA

>In-frame_ENST00000539824_ENST00000443566_TCGA-CD-5798-01A_SH3TC1_chr4_8216307_+_FNBP1_chr9_132658275_length(amino acids)=201AA_start in transcript=188_stop in transcript=793
MGESGARGGQGASERRETWSVWRLQRSQAFAWSPLILGTCCVADEAPPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQ
TLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNED

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SH3TC1-FNBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416550_617533.3333333333334593.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416535_617533.3333333333334593.0DNM1 and DNM3
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416553_609533.3333333333334593.0DNM2 and WASL
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416553_610533.3333333333334593.0FASLG


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417550_617562.3333333333334618.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417535_617562.3333333333334618.0DNM1 and DNM3
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417553_609562.3333333333334618.0DNM2 and WASL
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417553_610562.3333333333334618.0FASLG
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_335533.3333333333334593.0microtubules
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_335562.3333333333334618.0microtubules
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416495_617533.3333333333334593.0PDE6G
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417495_617562.3333333333334618.0PDE6G
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416400_552533.3333333333334593.0RND2
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417400_552562.3333333333334618.0RND2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SH3TC1-FNBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SH3TC1-FNBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3TC1C0009402Colorectal Carcinoma1CTD_human;UNIPROT
HgeneSH3TC1C0009404Colorectal Neoplasms1CTD_human
TgeneFNBP1C3495676Anorectal Malformations1GENOMICS_ENGLAND