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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHANK2-HMGN3 (FusionGDB2 ID:80992)

Fusion Gene Summary for SHANK2-HMGN3

check button Fusion gene summary
Fusion gene informationFusion gene name: SHANK2-HMGN3
Fusion gene ID: 80992
HgeneTgene
Gene symbol

SHANK2

HMGN3

Gene ID

22941

9324

Gene nameSH3 and multiple ankyrin repeat domains 2high mobility group nucleosomal binding domain 3
SynonymsAUTS17|CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3PNAS-24|PNAS-25|TRIP7
Cytomap

11q13.3-q13.4

6q14.1

Type of geneprotein-codingprotein-coding
DescriptionSH3 and multiple ankyrin repeat domains protein 2GKAP/SAPAP interacting proteincortactin SH3 domain-binding proteincortactin-binding protein 1proline-rich synapse associated protein 1high mobility group nucleosome-binding domain-containing protein 3TR-interacting protein 7thyroid hormone receptor interacting protein 7
Modification date2020032620200313
UniProtAcc.

Q15651

Ensembl transtripts involved in fusion geneENST00000449833, ENST00000409161, 
ENST00000423696, ENST00000338508, 
ENST00000409530, ENST00000449116, 
ENST00000357171, ENST00000468619, 
ENST00000275036, ENST00000344726, 
Fusion gene scores* DoF score50 X 31 X 10=155007 X 5 X 4=140
# samples 517
** MAII scorelog2(51/15500*10)=-4.9256271581901
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHANK2 [Title/Abstract] AND HMGN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHANK2(70505933)-HMGN3(79924739), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SHANK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HMGN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Z-01ASHANK2chr11

70505933

-HMGN3chr6

79924739

-


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Fusion Gene ORF analysis for SHANK2-HMGN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000449833ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000449833ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000409161ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000409161ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000423696ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000423696ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000338508ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000338508ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000409530ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000409530ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000449116ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000449116ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000357171ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
In-frameENST00000357171ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-
intron-3CDSENST00000468619ENST00000275036SHANK2chr11

70505933

-HMGN3chr6

79924739

-
intron-3CDSENST00000468619ENST00000344726SHANK2chr11

70505933

-HMGN3chr6

79924739

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449833SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-103534845566173
ENST00000449833SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-107634845632195
ENST00000409161SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-9812940512170
ENST00000409161SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-10222940578192
ENST00000423696SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-1648961371179380
ENST00000423696SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-1689961371245402
ENST00000338508SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-2751206402282760
ENST00000338508SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-2792206402348782
ENST00000409530SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-9812940512170
ENST00000409530SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-10222940578192
ENST00000449116SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-105737067588173
ENST00000449116SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-109837067654195
ENST00000357171SHANK2chr1170505933-ENST00000275036HMGN3chr679924739-103534845566173
ENST00000357171SHANK2chr1170505933-ENST00000344726HMGN3chr679924739-107634845632195

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449833ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.0026073950.99739254
ENST00000449833ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0010071160.99899286
ENST00000409161ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.00216190.9978381
ENST00000409161ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0010291210.99897087
ENST00000423696ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.0023669220.9976331
ENST00000423696ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0018580130.998142
ENST00000338508ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.0031613270.9968387
ENST00000338508ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0026504390.9973495
ENST00000409530ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.00216190.9978381
ENST00000409530ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0010291210.99897087
ENST00000449116ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.0024708430.9975292
ENST00000449116ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0009480850.99905187
ENST00000357171ENST00000275036SHANK2chr1170505933-HMGN3chr679924739-0.0026073950.99739254
ENST00000357171ENST00000344726SHANK2chr1170505933-HMGN3chr679924739-0.0010071160.99899286

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Fusion Genomic Features for SHANK2-HMGN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SHANK2-HMGN3


check button Go to

FGviewer for the breakpoints of chr11:70505933-chr6:79924739

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HMGN3

Q15651

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHANK2chr11:70505933chr6:79924739ENST00000423696-716147_206308.01471.0DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHANK2chr11:70505933chr6:79924739ENST00000423696-716509_535308.01471.0Compositional biasNote=Pro-rich
HgeneSHANK2chr11:70505933chr6:79924739ENST00000449833-210509_53599.01255.0Compositional biasNote=Pro-rich
HgeneSHANK2chr11:70505933chr6:79924739ENST00000423696-7161407_1470308.01471.0DomainSAM
HgeneSHANK2chr11:70505933chr6:79924739ENST00000423696-716247_341308.01471.0DomainPDZ
HgeneSHANK2chr11:70505933chr6:79924739ENST00000449833-2101407_147099.01255.0DomainSAM
HgeneSHANK2chr11:70505933chr6:79924739ENST00000449833-210147_20699.01255.0DomainSH3
HgeneSHANK2chr11:70505933chr6:79924739ENST00000449833-210247_34199.01255.0DomainPDZ
HgeneSHANK2chr11:70505933chr6:79924739ENST00000423696-716948_954308.01471.0MotifSH3-binding
HgeneSHANK2chr11:70505933chr6:79924739ENST00000449833-210948_95499.01255.0MotifSH3-binding


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Fusion Gene Sequence for SHANK2-HMGN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000449833_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1035nt_BP=348nt
TCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTG
ATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAA
AAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCC
CTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAAT
ACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCT
GAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAA
GCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCT
TGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAG
GATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGT
GTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTT
CATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTG

>In-frame_ENST00000449833_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=173AA_start in transcript=45_stop in transcript=566
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ

--------------------------------------------------------------
>In-frame_ENST00000449833_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1076nt_BP=348nt
TCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTG
ATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAA
AAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCC
CTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAAT
ACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCT
GAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAA
GCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAA
TGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAA
TTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCA
TCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCT
GTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTT

>In-frame_ENST00000449833_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=195AA_start in transcript=45_stop in transcript=632
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ
AGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETK

--------------------------------------------------------------
>In-frame_ENST00000409161_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=981nt_BP=294nt
ATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGAC
TGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCC
ATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTA
AGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCT
GCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGC
AGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAAT
TGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTT
TAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTC
AAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCA
TACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATG

>In-frame_ENST00000409161_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=170AA_start in transcript=0_stop in transcript=512
MMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGL

--------------------------------------------------------------
>In-frame_ENST00000409161_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1022nt_BP=294nt
ATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGAC
TGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCC
ATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTA
AGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCT
GCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGC
AGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAG
GCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTT
AAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTA
TCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGAT
TCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTC
TAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTGCTGACTATTTGTG

>In-frame_ENST00000409161_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=192AA_start in transcript=0_stop in transcript=578
MMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGL
RTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEE

--------------------------------------------------------------
>In-frame_ENST00000423696_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1648nt_BP=961nt
ATATAATGAGCGGACCGCTGCCAAAGTCAGAGGGAAAATGAAGTCTTTGTTAAATGCCTTCACCAAGAAGGAAGTGCCCTTCCGAGAGGC
CCCGGCGTACTCCAACCGCCGGCGGCGGCCCCCCAACACGCTGGCCGCCCCCCGGGTCCTGCTGCGCTCCAACAGTGACAACAACCTCAA
TGCCAGCGCTCCCGACTGGGCCGTCTGCTCCACGGCCACCTCGCACCGCAGCCTGTCACCCCAGCTGCTGCAGCAGATGCCCAGCAAGCC
CGAGGGGGCCGCGAAGACCATTGGGAGCTACGTGCCCGGGCCCCGCAGCCGGTCCCCATCGCTCAACAGGCTGGGCGGCGCAGGCGAGGA
CGGCAAGAGGCCGCAGCCTCTCTGGCATGTCGGGTCGCCTTTTGCTCTTGGTGCCAACAAGGACTCACTCTCGGCCTTCGAGTACCCGGG
GCCCAAGCGGAAGCTCTACAGTGCCGTGCCCGGGAGGCTCTTCGTCGCTGTCAAGCCATACCAACCCCAAGTGGACGGCGAGATCCCCCT
TCACCGCGGTGACAGGGTCAAAGTTCTGAGCATCGGTGAAGGGGGCTTCTGGGAAGGCAGCGCCCGCGGCCACATCGGATGGTTTCCGGC
GGAGTGCGTGGAGGAGGTCCAGTGTAAGCCCAGGGACAGCCAGGCAGAAACCCGCGCTGACCGCAGCAAGAAGCTTTTCAGGCACTACAC
CGTGGGCTCCTATGACAGCTTCGACACTTCCAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTT
TGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTC
CGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGG
ATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAA
AACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGCAC
AGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAA
GCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGT
CTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAG
CATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGA
GCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTGCTGACTATTTGTGGTTT

>In-frame_ENST00000423696_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=380AA_start in transcript=37_stop in transcript=1179
MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVP
GPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIG
EGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTP
IEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKIS

--------------------------------------------------------------
>In-frame_ENST00000423696_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1689nt_BP=961nt
ATATAATGAGCGGACCGCTGCCAAAGTCAGAGGGAAAATGAAGTCTTTGTTAAATGCCTTCACCAAGAAGGAAGTGCCCTTCCGAGAGGC
CCCGGCGTACTCCAACCGCCGGCGGCGGCCCCCCAACACGCTGGCCGCCCCCCGGGTCCTGCTGCGCTCCAACAGTGACAACAACCTCAA
TGCCAGCGCTCCCGACTGGGCCGTCTGCTCCACGGCCACCTCGCACCGCAGCCTGTCACCCCAGCTGCTGCAGCAGATGCCCAGCAAGCC
CGAGGGGGCCGCGAAGACCATTGGGAGCTACGTGCCCGGGCCCCGCAGCCGGTCCCCATCGCTCAACAGGCTGGGCGGCGCAGGCGAGGA
CGGCAAGAGGCCGCAGCCTCTCTGGCATGTCGGGTCGCCTTTTGCTCTTGGTGCCAACAAGGACTCACTCTCGGCCTTCGAGTACCCGGG
GCCCAAGCGGAAGCTCTACAGTGCCGTGCCCGGGAGGCTCTTCGTCGCTGTCAAGCCATACCAACCCCAAGTGGACGGCGAGATCCCCCT
TCACCGCGGTGACAGGGTCAAAGTTCTGAGCATCGGTGAAGGGGGCTTCTGGGAAGGCAGCGCCCGCGGCCACATCGGATGGTTTCCGGC
GGAGTGCGTGGAGGAGGTCCAGTGTAAGCCCAGGGACAGCCAGGCAGAAACCCGCGCTGACCGCAGCAAGAAGCTTTTCAGGCACTACAC
CGTGGGCTCCTATGACAGCTTCGACACTTCCAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTT
TGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTC
CGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGG
ATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAA
AACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGTAC
TGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAA
TTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACT
AGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAA
TATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTT
TTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGA

>In-frame_ENST00000423696_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=402AA_start in transcript=37_stop in transcript=1245
MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQLLQQMPSKPEGAAKTIGSYVP
GPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQPQVDGEIPLHRGDRVKVLSIG
EGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTP
IEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKIS

--------------------------------------------------------------
>In-frame_ENST00000338508_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=2751nt_BP=2064nt
ATGCCGCGCAGCCCAACATCCAGCGAGGACGAGATGGCCCAGAGCTTCTCCGACTACTCCGTGGGGTCGGAGTCAGACAGCTCCAAAGAA
GAGACCATCTATGACACGATCCGGGCCACTGCGGAGAAGCCGGGCGGTGCCAGGACGGAGGAGAGCCAGGGCAACACGCTGGTGATCCGC
GTGGTCATCCATGACCTGCAGCAGACGAAATGCATTCGATTTAACCCGGATGCCACAGTGTGGGTTGCAAAGCAGCGGATCCTGTGTACA
TTAACCCAGAGTTTGAAAGATGTCCTGAACTACGGCCTGTTCCAGCCGGCCAGCAATGGGCGTGACGGCAAGTTCCTGGATGAGGAGCGG
CTCCTGCGCGAGTACCCACAGCCCGTGGGTGAGGGCGTTCCTTCCCTGGAGTTTCGATACAAGAAGCGGGTGTATAAACAAGCCAGTCTC
GATGAGAAACAGTTGGCCAAGCTCCACACGAAGACCAATCTGAAGAAATGCATGGATCACATTCAGCATCGCTTGGTGGAGAAGATCACC
AAGATGCTGGACCGAGGCCTGGATCCCAATTTCCACGACCCGGAGACCGGAGAGACCCCCCTGACCTTAGCCGCTCAGCTGGACGACTCT
GTGGAGGTCATCAAAGCTCTCAAAAATGGTGGAGCTCACCTGGACTTCCGTGCCAAAGATGGGATGACCGCCCTACACAAAGCTGCCCGA
GCGAGGAACCAAGTTGCCCTGAAGACCCTTTTAGAGCTTGGTGCATCCCCAGATTATAAAGACAGTTACGGCCTCACCCCGCTGTATCAC
ACAGCCATCGTCGGAGGTGATCCCTACTGCTGCGAGCTTCTCCTGCACGAACACGCCACTGTGTGCTGCAAAGATGAGAACGGCTGGCAC
GAGATCCACCAGTCTAGGTGCTGGGGACACATCAGTGAGCCACACCACACTCTGCTCTCTGGAAGTGCACGAAGTCAACAAAGCCGAAGT
GCTTCCTCTGCACTCCATGTCTGTGCTATGTATTCATCTTTTTCCTGTGTCAGAATCTCGTTGCTTTTTCATGGCCGAATAACTGAATTA
AAACAGTACAAAAAGAGCACCCCCTTCCAGGTGGCCATAATAGCAGGCAACTTTGAGCTGGCAGAATACATCAAGAACCACAAGGAAACA
GACATTGTGCCCTTCCGAGAGGCCCCGGCGTACTCCAACCGCCGGCGGCGGCCCCCCAACACGCTGGCCGCCCCCCGGGTCCTGCTGCGC
TCCAACAGTGACAACAACCTCAATGCCAGCGCTCCCGACTGGGCCGTCTGCTCCACGGCCACCTCGCACCGCAGCCTGTCACCCCAGCTG
CTGCAGCAGATGCCCAGCAAGCCCGAGGGGGCCGCGAAGACCATTGGGAGCTACGTGCCCGGGCCCCGCAGCCGGTCCCCATCGCTCAAC
AGGCTGGGCGGCGCAGGCGAGGACGGCAAGAGGCCGCAGCCTCTCTGGCATGTCGGGTCGCCTTTTGCTCTTGGTGCCAACAAGGACTCA
CTCTCGGCCTTCGAGTACCCGGGGCCCAAGCGGAAGCTCTACAGTGCCGTGCCCGGGAGGCTCTTCGTCGCTGTCAAGCCATACCAACCC
CAAGTGGACGGCGAGATCCCCCTTCACCGCGGTGACAGGGTCAAAGTTCTGAGCATCGGTGAAGGGGGCTTCTGGGAAGGCAGCGCCCGC
GGCCACATCGGATGGTTTCCGGCGGAGTGCGTGGAGGAGGTCCAGTGTAAGCCCAGGGACAGCCAGGCAGAAACCCGCGCTGACCGCAGC
AAGAAGCTTTTCAGGCACTACACCGTGGGCTCCTATGACAGCTTCGACACTTCCAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTG
CAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTC
CCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCA
GAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCA
AAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAG
CAGGAAGCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGT
ATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATA
TATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGA
AGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGA
ATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGC

>In-frame_ENST00000338508_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=760AA_start in transcript=0_stop in transcript=2282
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCT
LTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH
TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQSRCWGHISEPHHTLLSGSARSQQSRSASSALHVCAMYSSFSCVRISLLFHGRITEL
KQYKKSTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQL
LQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQP
QVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVL
QKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPP

--------------------------------------------------------------
>In-frame_ENST00000338508_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=2792nt_BP=2064nt
ATGCCGCGCAGCCCAACATCCAGCGAGGACGAGATGGCCCAGAGCTTCTCCGACTACTCCGTGGGGTCGGAGTCAGACAGCTCCAAAGAA
GAGACCATCTATGACACGATCCGGGCCACTGCGGAGAAGCCGGGCGGTGCCAGGACGGAGGAGAGCCAGGGCAACACGCTGGTGATCCGC
GTGGTCATCCATGACCTGCAGCAGACGAAATGCATTCGATTTAACCCGGATGCCACAGTGTGGGTTGCAAAGCAGCGGATCCTGTGTACA
TTAACCCAGAGTTTGAAAGATGTCCTGAACTACGGCCTGTTCCAGCCGGCCAGCAATGGGCGTGACGGCAAGTTCCTGGATGAGGAGCGG
CTCCTGCGCGAGTACCCACAGCCCGTGGGTGAGGGCGTTCCTTCCCTGGAGTTTCGATACAAGAAGCGGGTGTATAAACAAGCCAGTCTC
GATGAGAAACAGTTGGCCAAGCTCCACACGAAGACCAATCTGAAGAAATGCATGGATCACATTCAGCATCGCTTGGTGGAGAAGATCACC
AAGATGCTGGACCGAGGCCTGGATCCCAATTTCCACGACCCGGAGACCGGAGAGACCCCCCTGACCTTAGCCGCTCAGCTGGACGACTCT
GTGGAGGTCATCAAAGCTCTCAAAAATGGTGGAGCTCACCTGGACTTCCGTGCCAAAGATGGGATGACCGCCCTACACAAAGCTGCCCGA
GCGAGGAACCAAGTTGCCCTGAAGACCCTTTTAGAGCTTGGTGCATCCCCAGATTATAAAGACAGTTACGGCCTCACCCCGCTGTATCAC
ACAGCCATCGTCGGAGGTGATCCCTACTGCTGCGAGCTTCTCCTGCACGAACACGCCACTGTGTGCTGCAAAGATGAGAACGGCTGGCAC
GAGATCCACCAGTCTAGGTGCTGGGGACACATCAGTGAGCCACACCACACTCTGCTCTCTGGAAGTGCACGAAGTCAACAAAGCCGAAGT
GCTTCCTCTGCACTCCATGTCTGTGCTATGTATTCATCTTTTTCCTGTGTCAGAATCTCGTTGCTTTTTCATGGCCGAATAACTGAATTA
AAACAGTACAAAAAGAGCACCCCCTTCCAGGTGGCCATAATAGCAGGCAACTTTGAGCTGGCAGAATACATCAAGAACCACAAGGAAACA
GACATTGTGCCCTTCCGAGAGGCCCCGGCGTACTCCAACCGCCGGCGGCGGCCCCCCAACACGCTGGCCGCCCCCCGGGTCCTGCTGCGC
TCCAACAGTGACAACAACCTCAATGCCAGCGCTCCCGACTGGGCCGTCTGCTCCACGGCCACCTCGCACCGCAGCCTGTCACCCCAGCTG
CTGCAGCAGATGCCCAGCAAGCCCGAGGGGGCCGCGAAGACCATTGGGAGCTACGTGCCCGGGCCCCGCAGCCGGTCCCCATCGCTCAAC
AGGCTGGGCGGCGCAGGCGAGGACGGCAAGAGGCCGCAGCCTCTCTGGCATGTCGGGTCGCCTTTTGCTCTTGGTGCCAACAAGGACTCA
CTCTCGGCCTTCGAGTACCCGGGGCCCAAGCGGAAGCTCTACAGTGCCGTGCCCGGGAGGCTCTTCGTCGCTGTCAAGCCATACCAACCC
CAAGTGGACGGCGAGATCCCCCTTCACCGCGGTGACAGGGTCAAAGTTCTGAGCATCGGTGAAGGGGGCTTCTGGGAAGGCAGCGCCCGC
GGCCACATCGGATGGTTTCCGGCGGAGTGCGTGGAGGAGGTCCAGTGTAAGCCCAGGGACAGCCAGGCAGAAACCCGCGCTGACCGCAGC
AAGAAGCTTTTCAGGCACTACACCGTGGGCTCCTATGACAGCTTCGACACTTCCAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTG
CAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTC
CCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCA
GAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCA
AAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAG
CAGGAAGCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAGGCACAGAAAACTGAATCTGTAGATAACGAG
GGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAA
TGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTT
ACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTT
AGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACC
TAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTGCTGACTATTTGTGGTTTAAAATAAAAGGTTTACTTGTCTGCAG

>In-frame_ENST00000338508_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=782AA_start in transcript=0_stop in transcript=2348
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCT
LTQSLKDVLNYGLFQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH
TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQSRCWGHISEPHHTLLSGSARSQQSRSASSALHVCAMYSSFSCVRISLLFHGRITEL
KQYKKSTPFQVAIIAGNFELAEYIKNHKETDIVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNASAPDWAVCSTATSHRSLSPQL
LQQMPSKPEGAAKTIGSYVPGPRSRSPSLNRLGGAGEDGKRPQPLWHVGSPFALGANKDSLSAFEYPGPKRKLYSAVPGRLFVAVKPYQP
QVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDTSSDCIIEEKTVVL
QKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPP

--------------------------------------------------------------
>In-frame_ENST00000409530_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=981nt_BP=294nt
ATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGAC
TGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCC
ATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTA
AGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCT
GCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGC
AGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAAT
TGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTT
TAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTC
AAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCA
TACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATG

>In-frame_ENST00000409530_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=170AA_start in transcript=0_stop in transcript=512
MMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGL

--------------------------------------------------------------
>In-frame_ENST00000409530_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1022nt_BP=294nt
ATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGAC
TGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCC
ATTGAAGAATTCACACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTA
AGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCT
GCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGC
AGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAG
GCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTT
AAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTA
TCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGAT
TCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTC
TAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTGCTGACTATTTGTG

>In-frame_ENST00000409530_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=192AA_start in transcript=0_stop in transcript=578
MMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGL
RTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEE

--------------------------------------------------------------
>In-frame_ENST00000449116_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1057nt_BP=370nt
CTCCTCCTGCACCCTCGCTGCCTCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCC
CGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGA
GAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCAC
ACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTT
CTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGC
GAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGG
GAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATT
GGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAG
TTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATA
TCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTT
TACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAA

>In-frame_ENST00000449116_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=173AA_start in transcript=67_stop in transcript=588
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ

--------------------------------------------------------------
>In-frame_ENST00000449116_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1098nt_BP=370nt
CTCCTCCTGCACCCTCGCTGCCTCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCC
CGGCGGAGGAGCGGCCGCGGTGATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGA
GAAGACGGTGGTCCTGCAGAAAAAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCAC
ACCAACACCGGCTTTCCCAGCCCTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTT
CTTGATTGAGTCTCCAGAGAATACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGC
GAAACCTGCTCCACCAAAACCTGAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGG
GAAGAAGGAGGAAAAGCAGGAAGCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAGGCACAGAAAACTGA
ATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTA
CCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCA
TGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGC
ACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCA
GTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTGCTGACTATTTGTGGTTTAAAATAAAAG

>In-frame_ENST00000449116_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=195AA_start in transcript=67_stop in transcript=654
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ
AGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETK

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>In-frame_ENST00000357171_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1035nt_BP=348nt
TCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTG
ATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAA
AAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCC
CTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAAT
ACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCT
GAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAA
GCTGGAAAGGAAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAATGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCT
TGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAATTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAG
GATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCATCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGT
GTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCTGTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTT
CATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTTTTATGTGATTTTAATGAAACATGGATAGTTGTGGCCACCTG

>In-frame_ENST00000357171_ENST00000275036_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=173AA_start in transcript=45_stop in transcript=566
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ

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>In-frame_ENST00000357171_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(transcript)=1076nt_BP=348nt
TCCTTTCCTCCATGCTGCCTGGATCTGGCGAGCTGGGGTGATTAATTGGCTATGATGATGAACGTCCCCGGCGGAGGAGCGGCCGCGGTG
ATGATGACGGGCTACAATAATGGTCGCTGTCCCCGGAATTCTCTCTACAGTGACTGCATTATTGAGGAGAAGACGGTGGTCCTGCAGAAA
AAAGACAATGAGGGCTTTGGATTCGTGCTTCGAGGGGCCAAAGCTGACACACCCATTGAAGAATTCACACCAACACCGGCTTTCCCAGCC
CTACAGTACCTGGAGTCCGTGGATGAAGGTGGGGTGGCGTGGCAAGCCGGACTAAGGACCGGGGACTTCTTGATTGAGTCTCCAGAGAAT
ACAGAGGGCAAAGATGGATCCAAAGTAACTAAACAGGAGCCCACAAGACGGTCTGCCAGATTGTCAGCGAAACCTGCTCCACCAAAACCT
GAACCCAAACCAAGAAAAACATCTGCTAAGAAAGAACCTGGAGCAAAGATTAGCAGAGGTGCTAAAGGGAAGAAGGAGGAAAAGCAGGAA
GCTGGAAAGGAAGGTACTGCACCATCTGAAAATGGTGAAACTAAAGCTGAAGAGGCACAGAAAACTGAATCTGTAGATAACGAGGGAGAA
TGAATTGTCATGAAAAATTGGGGTTGATTTTATGTATCTCTTGGGACAACTTTTAAAAGCTATTTTTACCAAGTATTTTGTAAATGCTAA
TTTTTTAGGACTCTACTAGTTGGCATACGAAAATATATAAGGATGGACATTTTATCGTCTCATAGTCATGCTTTTTGGAAATTTACATCA
TCCTCAAGTAAAATAAATATCAGTTAAATATTGGAAGCTGTGTGTAAGATTGATTCAGCATTCCATGCACTTGCTTTAAAATTTAGTCCT
GTGCATACTGTGGTGTTTTTACTGTGCATATTTGAATTTTTCATGCAGTTTTTCTAGAGCAATAATCAGTGGTGCTTTTGTACCTAGGTT

>In-frame_ENST00000357171_ENST00000344726_TCGA-AR-A24Z-01A_SHANK2_chr11_70505933_-_HMGN3_chr6_79924739_length(amino acids)=195AA_start in transcript=45_stop in transcript=632
MAMMMNVPGGGAAAVMMTGYNNGRCPRNSLYSDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQ
AGLRTGDFLIESPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPRKTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETK

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Fusion Gene PPI Analysis for SHANK2-HMGN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHANK2-HMGN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHANK2-HMGN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSHANK2C0004352Autistic Disorder2CTD_human
HgeneSHANK2C0005586Bipolar Disorder1CTD_human
HgeneSHANK2C0005587Depression, Bipolar1CTD_human
HgeneSHANK2C0020796Profound Mental Retardation1CTD_human
HgeneSHANK2C0024713Manic Disorder1CTD_human
HgeneSHANK2C0025363Mental Retardation, Psychosocial1CTD_human
HgeneSHANK2C0338831Manic1CTD_human
HgeneSHANK2C0917816Mental deficiency1CTD_human
HgeneSHANK2C3150693AUTISM, SUSCEPTIBILITY TO, 171GENOMICS_ENGLAND
HgeneSHANK2C3714756Intellectual Disability1CTD_human