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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SHC1-IQGAP3 (FusionGDB2 ID:81064)

Fusion Gene Summary for SHC1-IQGAP3

Fusion gene summary

Fusion gene information	Fusion gene name: SHC1-IQGAP3
	Fusion gene ID: 81064
		Hgene	Tgene
	Gene symbol	SHC1	IQGAP3
	Gene ID	6464	128239
	Gene name	SHC adaptor protein 1	IQ motif containing GTPase activating protein 3
	Synonyms	SHC\|SHCA	-
	Cytomap	1q21.3	1q22
	Type of gene	protein-coding	protein-coding
	Description	SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A	ras GTPase-activating-like protein IQGAP3
	Modification date	20200327	20200329
	UniProtAcc	.	Q86VI3
	Ensembl transtripts involved in fusion gene	ENST00000368445, ENST00000368449, ENST00000448116, ENST00000368450, ENST00000368453, ENST00000606391, ENST00000490667,	ENST00000361170, ENST00000498755,
Fusion gene scores	* DoF score	12 X 13 X 8=1248	5 X 5 X 6=150
	# samples	15	7
	** MAII score	log2(15/1248*10)=-3.05658352836637 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SHC1 [Title/Abstract] AND IQGAP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SHC1(154940680)-IQGAP3(156498874), # samples:2
Anticipated loss of major functional domain due to fusion event.	SHC1-IQGAP3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SHC1	GO:0000165	MAPK cascade	14676841
Hgene	SHC1	GO:0000187	activation of MAPK activity	14676841
Hgene	SHC1	GO:0071363	cellular response to growth factor stimulus	20010870

Fusion gene breakpoints across SHC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IQGAP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A3AD-06A	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
ChimerDB4	SKCM	TCGA-EE-A3AD-06A	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-

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Fusion Gene ORF analysis for SHC1-IQGAP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000368445	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000368445	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
In-frame	ENST00000368449	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000368449	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
In-frame	ENST00000448116	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000448116	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
Frame-shift	ENST00000368450	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000368450	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
Frame-shift	ENST00000368453	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000368453	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
In-frame	ENST00000606391	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
5CDS-intron	ENST00000606391	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
intron-3CDS	ENST00000490667	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-
intron-intron	ENST00000490667	ENST00000498755	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368445	SHC1	chr1	154940680	-	ENST00000361170	IQGAP3	chr1	156498874	-	2592	1019	101	1510	469
ENST00000368449	SHC1	chr1	154940680	-	ENST00000361170	IQGAP3	chr1	156498874	-	1999	426	156	917	253
ENST00000448116	SHC1	chr1	154940680	-	ENST00000361170	IQGAP3	chr1	156498874	-	2598	1025	107	1516	469
ENST00000606391	SHC1	chr1	154940680	-	ENST00000361170	IQGAP3	chr1	156498874	-	1780	207	0	698	232

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000368445	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-	0.006604284	0.99339575
ENST00000368449	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-	0.011151972	0.988848
ENST00000448116	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-	0.006635478	0.9933646
ENST00000606391	ENST00000361170	SHC1	chr1	154940680	-	IQGAP3	chr1	156498874	-	0.004227539	0.9957724

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Fusion Genomic Features for SHC1-IQGAP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SHC1-IQGAP3

Go to
FGviewer for the breakpoints of chr1:154940680-chr1:156498874
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IQGAP3 Q86VI3
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368445

411_474

268.0

584.0

Compositional bias

Note=Pro-rich

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368450

411_474

158.0

474.0

Compositional bias

Note=Pro-rich

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368453

411_474

158.0

475.0

Compositional bias

Note=Pro-rich

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000448116

411_474

268.0

585.0

Compositional bias

Note=Pro-rich

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368445

156_339

268.0

584.0

Domain

PID

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368445

488_579

268.0

584.0

Domain

SH2

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368450

156_339

158.0

474.0

Domain

PID

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368450

488_579

158.0

474.0

Domain

SH2

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368453

156_339

158.0

475.0

Domain

PID

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368453

488_579

158.0

475.0

Domain

SH2

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000448116

156_339

268.0

585.0

Domain

PID

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000448116

488_579

268.0

585.0

Domain

SH2

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368445

340_487

268.0

584.0

Region

Note=CH1

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368450

340_487

158.0

474.0

Region

Note=CH1

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000368453

340_487

158.0

475.0

Region

Note=CH1

Hgene

SHC1

chr1:154940680

chr1:156498874

ENST00000448116

340_487

268.0

585.0

Region

Note=CH1

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

34_149

1468.0

1632.0

Domain

Calponin-homology (CH)

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

730_759

1468.0

1632.0

Domain

IQ 1

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

760_789

1468.0

1632.0

Domain

IQ 2

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

790_819

1468.0

1632.0

Domain

IQ 3

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

820_849

1468.0

1632.0

Domain

IQ 4

Tgene

IQGAP3

chr1:154940680

chr1:156498874

ENST00000361170

988_1221

1468.0

1632.0

Domain

Ras-GAP

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Fusion Gene Sequence for SHC1-IQGAP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000368445_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(transcript)=2592nt_BP=1019nt
GAGGCTCCACGTTGGGCGGGGATGGGGCCTGAAACTGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCCCAGGAC
TTCTGTGACTCCTGGGCCACAGAGGTCCAACCAGGCTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCAGGGGGG
CCAGGCTGGGCAGCAGCCCCTCTTTCACCTCAACTATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGTCTCTGT
CATCGCTGGAGGAAGGGGCTTCTGGGTCCACCCCCCCGGAGGAGCTGCCTTCCCCATCAGCTTCATCCCTGGGGCCCATCCTGCCTCCTC
TGCCTGGGGACGATAGTCCCACTACCCTGTGCTCCTTCTTCCCCCGGATGAGCAACCTGAGGCTGGCCAACCCGGCTGGGGGGCGCCCAG
GGTCTAAGGGGGAGCCAGGAAGGGCAGCTGATGATGGGGAGGGGATCGTAGGGGCAGCCATGCCAGACTCAGGCCCCCTACCCCTCCTCC
AGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCCACGGGA
GCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGGTTCGGTACATGGGTT
GTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTGAGGCTG
TGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTG
GAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACATGCAAT
CTATCTCATTTGCATCCGGCGGGGATCCGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGAAGGCAGAGCTGGTGAAGCTGCAGG
CCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGGTGACTACTACAGCCAGTACATCCGGGCCTGCCTGGACCACC
TGGCCCCCGACTCCAAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTCCTGGAAAAGGGTGTCTTGG
TGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATCACGCCGGGAGATGAGGCAGGAAAGTTTGAAGTAAATG
CCAAGTTCCTGGGTGTGGACATGGAGCGATTTCAGCTTCACTATCAGGATCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGAAAC
TCTTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCGGAAGTGACAGAGGCAAAGGGTGCTAC
CCAAGCCCCTCTTACCTCTCTGGATGCTTTCTTTAACACTAACTCACCACTGTGCTTCCCTGCAGACACCTAGAGCTCAGGACTGGGCAA
GGCCCAGGGATTCTCACCCCTTCCCCAGCTGGGAGGAGCTTGCCTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGTGGGCCT
TGCCCAGAGTCCAGCTGTGTGGCTTTTATCATGCATGACAAACCCCTGGCTTTCCTGCCAGATGGTAGGACATGGACCTTGACCTGGGAA
AGCCATTACTCTTGTGTCTGCTACTGCCCTCCCACAGTCACCCCAATATTACAAGCACTGCCCCAGCGGCTTGATTTCCCCTCTGCCTTC
CTTCTCTCTGCACTCCCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGTTCCTGCCCTTCCTGAGT
CTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTCCAACCTGGGCAGGGACTGGGGGGATGCAGTGTGTGTTAGTGCCCATGTGGCATTG
TGGCACTGTTGCCCCCCATGGCGGCATGGGCAAGATGACCTTCCATTAGCTTCAAGTCTTGTTCTCTTGTCTGTGGTCTGTTTAATATGT
GGGTCACTAGGGTATTTATTCTTTCTCCCATCCTTACACTCTGGATCATTGTGCAGACTTAATCAGGGTTTTAACGCTTTCATTTTTTTT
TTTTTTTTTTTTTTTTTGAGCTCAAAGAGAGTTCTCATTTTCCCTATTCAAACTAATACCCATGCCGTGTTTTTTACCTTGGATTTAAAG
TCACCTTAGGTTGGGGCAACAGATTCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCAAAGAGGAGTCTTTCCCTTTTC
TCTTTTACCCTCAGGATTCTCATCCCTTACAGCTGACTCTTCCAGGCAATTTCCATAGATCTGCAGTCCTGCCTCTGCCACAGTCTCTCT

>In-frame_ENST00000368445_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(amino acids)=469AA_start in transcript=101_stop in transcript=1510
MGHRGPTRLRAWGYPLPGPLAQTGRGARLGSSPSFTSTMDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGD
DSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVN
KPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPI
TLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPD
SKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNK

--------------------------------------------------------------
>In-frame_ENST00000368449_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(transcript)=1999nt_BP=426nt
AGAGAAGAGGCTCCACGTTGGGCGGGGATGGGGCCTGAAACTGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCC
CAGGACTTCTGTGACTCCTGGGCCACAGAGGTCCAACCAGGCTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCA
GGGGGGCCAGGCTGGGCAGCAGCCCCTCTTTCACCTCAACTATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGT
CTCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCA
GACTGCAAACAGATCATCGCCAACCACCACATGCAATCTATCTCATTTGCATCCGGCGGGGATCCGGACATCCGCAACCAGCACAGACAC
AGGCACAGGCGGAAGGCAGAGCTGGTGAAGCTGCAGGCCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGGTGAC
TACTACAGCCAGTACATCCGGGCCTGCCTGGACCACCTGGCCCCCGACTCCAAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCAT
TACACTGCTGCTCAGCTCCTGGAAAAGGGTGTCTTGGTGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATC
ACGCCGGGAGATGAGGCAGGAAAGTTTGAAGTAAATGCCAAGTTCCTGGGTGTGGACATGGAGCGATTTCAGCTTCACTATCAGGATCTC
CTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGAAACTCTTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAG
AAGTTTTTGCGGAAGTGACAGAGGCAAAGGGTGCTACCCAAGCCCCTCTTACCTCTCTGGATGCTTTCTTTAACACTAACTCACCACTGT
GCTTCCCTGCAGACACCTAGAGCTCAGGACTGGGCAAGGCCCAGGGATTCTCACCCCTTCCCCAGCTGGGAGGAGCTTGCCTGCCTGGCC
ACAGACAGTGTATCTTCTAATTGGCTAAAGTGGGCCTTGCCCAGAGTCCAGCTGTGTGGCTTTTATCATGCATGACAAACCCCTGGCTTT
CCTGCCAGATGGTAGGACATGGACCTTGACCTGGGAAAGCCATTACTCTTGTGTCTGCTACTGCCCTCCCACAGTCACCCCAATATTACA
AGCACTGCCCCAGCGGCTTGATTTCCCCTCTGCCTTCCTTCTCTCTGCACTCCCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCC
ACTGCATCAGCAGTGGGTGTTCCTGCCCTTCCTGAGTCTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTCCAACCTGGGCAGGGACTG
GGGGGATGCAGTGTGTGTTAGTGCCCATGTGGCATTGTGGCACTGTTGCCCCCCATGGCGGCATGGGCAAGATGACCTTCCATTAGCTTC
AAGTCTTGTTCTCTTGTCTGTGGTCTGTTTAATATGTGGGTCACTAGGGTATTTATTCTTTCTCCCATCCTTACACTCTGGATCATTGTG
CAGACTTAATCAGGGTTTTAACGCTTTCATTTTTTTTTTTTTTTTTTTTTTTTTGAGCTCAAAGAGAGTTCTCATTTTCCCTATTCAAAC
TAATACCCATGCCGTGTTTTTTACCTTGGATTTAAAGTCACCTTAGGTTGGGGCAACAGATTCTCACTCATGTTTAAGATCTTGTTATTT
CAGCTTCATAAGATCAAAGAGGAGTCTTTCCCTTTTCTCTTTTACCCTCAGGATTCTCATCCCTTACAGCTGACTCTTCCAGGCAATTTC
CATAGATCTGCAGTCCTGCCTCTGCCACAGTCTCTCTGTTGTCCCCACATCTACCCAACTTCCTGTACTGTTGCCCTTCTGATGTTAATA

>In-frame_ENST00000368449_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(amino acids)=253AA_start in transcript=156_stop in transcript=917
MAPLPKLAGGPGWAAAPLSPQLWISCPPSPSTIHSGMSLSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDP
DIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASH

--------------------------------------------------------------
>In-frame_ENST00000448116_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(transcript)=2598nt_BP=1025nt
AGAGAAGAGGCTCCACGTTGGGCGGGGATGGGGCCTGAAACTGTCTGGGTCTGAGCTGGGGAGCGGAAGCCACTTGTCCCTCTCCCTCCC
CAGGACTTCTGTGACTCCTGGGCCACAGAGGTCCAACCAGGCTAAGGGCCTGGGGATACCCCCTGCCTGGCCCCCTTGCCCAAACTGGCA
GGGGGGCCAGGCTGGGCAGCAGCCCCTCTTTCACCTCAACTATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGT
CTCTGTCATCGCTGGAGGAAGGGGCTTCTGGGTCCACCCCCCCGGAGGAGCTGCCTTCCCCATCAGCTTCATCCCTGGGGCCCATCCTGC
CTCCTCTGCCTGGGGACGATAGTCCCACTACCCTGTGCTCCTTCTTCCCCCGGATGAGCAACCTGAGGCTGGCCAACCCGGCTGGGGGGC
GCCCAGGGTCTAAGGGGGAGCCAGGAAGGGCAGCTGATGATGGGGAGGGGATCGTAGGGGCAGCCATGCCAGACTCAGGCCCCCTACCCC
TCCTCCAGGACATGAACAAGCTGAGTGGAGGCGGCGGGCGCAGGACTCGGGTGGAAGGGGGCCAGCTTGGGGGCGAGGAGTGGACCCGCC
ACGGGAGCTTTGTCAATAAGCCCACGCGGGGCTGGCTGCATCCCAACGACAAAGTCATGGGACCCGGGGTTTCCTACTTGGTTCGGTACA
TGGGTTGTGTGGAGGTCCTCCAGTCAATGCGTGCCCTGGACTTCAACACCCGGACTCAGGTCACCAGGGAGGCCATCAGTCTGGTGTGTG
AGGCTGTGCCGGGTGCTAAGGGGGCGACAAGGAGGAGAAAGCCCTGTAGCCGCCCGCTCAGCTCTATCCTGGGGAGGAGTAACCTGAAAT
TTGCTGGAATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACA
TGCAATCTATCTCATTTGCATCCGGCGGGGATCCGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGAAGGCAGAGCTGGTGAAGC
TGCAGGCCACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGGTGACTACTACAGCCAGTACATCCGGGCCTGCCTGG
ACCACCTGGCCCCCGACTCCAAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTCCTGGAAAAGGGTG
TCTTGGTGGAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATCACGCCGGGAGATGAGGCAGGAAAGTTTGAAG
TAAATGCCAAGTTCCTGGGTGTGGACATGGAGCGATTTCAGCTTCACTATCAGGATCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCA
TGAAACTCTTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCGGAAGTGACAGAGGCAAAGGG
TGCTACCCAAGCCCCTCTTACCTCTCTGGATGCTTTCTTTAACACTAACTCACCACTGTGCTTCCCTGCAGACACCTAGAGCTCAGGACT
GGGCAAGGCCCAGGGATTCTCACCCCTTCCCCAGCTGGGAGGAGCTTGCCTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGT
GGGCCTTGCCCAGAGTCCAGCTGTGTGGCTTTTATCATGCATGACAAACCCCTGGCTTTCCTGCCAGATGGTAGGACATGGACCTTGACC
TGGGAAAGCCATTACTCTTGTGTCTGCTACTGCCCTCCCACAGTCACCCCAATATTACAAGCACTGCCCCAGCGGCTTGATTTCCCCTCT
GCCTTCCTTCTCTCTGCACTCCCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGTTCCTGCCCTTC
CTGAGTCTAGGCAGCTCTGCTGCTGTGATCTGCACACCCTCCAACCTGGGCAGGGACTGGGGGGATGCAGTGTGTGTTAGTGCCCATGTG
GCATTGTGGCACTGTTGCCCCCCATGGCGGCATGGGCAAGATGACCTTCCATTAGCTTCAAGTCTTGTTCTCTTGTCTGTGGTCTGTTTA
ATATGTGGGTCACTAGGGTATTTATTCTTTCTCCCATCCTTACACTCTGGATCATTGTGCAGACTTAATCAGGGTTTTAACGCTTTCATT
TTTTTTTTTTTTTTTTTTTTTTTGAGCTCAAAGAGAGTTCTCATTTTCCCTATTCAAACTAATACCCATGCCGTGTTTTTTACCTTGGAT
TTAAAGTCACCTTAGGTTGGGGCAACAGATTCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCAAAGAGGAGTCTTTCC
CTTTTCTCTTTTACCCTCAGGATTCTCATCCCTTACAGCTGACTCTTCCAGGCAATTTCCATAGATCTGCAGTCCTGCCTCTGCCACAGT

>In-frame_ENST00000448116_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(amino acids)=469AA_start in transcript=107_stop in transcript=1516
MGHRGPTRLRAWGYPLPGPLAQTGRGARLGSSPSFTSTMDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGD
DSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDSGPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVN
KPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRSNLKFAGMPI
TLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDIRNQHRHRHRRKAELVKLQATLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPD
SKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNAKFLGVDMERFQLHYQDLLQLQYEGVAVMKLFNK

--------------------------------------------------------------
>In-frame_ENST00000606391_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(transcript)=1780nt_BP=207nt
ATGGATCTCCTGCCCCCCAAGCCCAAGTACAATCCACTCCGGAATGAGTCTCTCTCTATCCTGGGGAGGAGTAACCTGAAATTTGCTGGA
ATGCCAATCACTCTCACCGTCTCCACCAGCAGCCTCAACCTCATGGCCGCAGACTGCAAACAGATCATCGCCAACCACCACATGCAATCT
ATCTCATTTGCATCCGGCGGGGATCCGGACATCCGCAACCAGCACAGACACAGGCACAGGCGGAAGGCAGAGCTGGTGAAGCTGCAGGCC
ACATTACAGGGCCTGAGCACTAAGACCACCTTCTATGAGGAGCAGGGTGACTACTACAGCCAGTACATCCGGGCCTGCCTGGACCACCTG
GCCCCCGACTCCAAGAGTTCTGGGAAGGGGAAGAAGCAGCCTTCTCTTCATTACACTGCTGCTCAGCTCCTGGAAAAGGGTGTCTTGGTG
GAAATTGAAGATCTTCCCGCCTCTCACTTCAGAAACGTCATCTTTGACATCACGCCGGGAGATGAGGCAGGAAAGTTTGAAGTAAATGCC
AAGTTCCTGGGTGTGGACATGGAGCGATTTCAGCTTCACTATCAGGATCTCCTGCAGCTCCAGTATGAGGGTGTGGCTGTCATGAAACTC
TTCAACAAGGCCAAAGTCAATGTCAACCTTCTCATCTTCCTCCTCAACAAGAAGTTTTTGCGGAAGTGACAGAGGCAAAGGGTGCTACCC
AAGCCCCTCTTACCTCTCTGGATGCTTTCTTTAACACTAACTCACCACTGTGCTTCCCTGCAGACACCTAGAGCTCAGGACTGGGCAAGG
CCCAGGGATTCTCACCCCTTCCCCAGCTGGGAGGAGCTTGCCTGCCTGGCCACAGACAGTGTATCTTCTAATTGGCTAAAGTGGGCCTTG
CCCAGAGTCCAGCTGTGTGGCTTTTATCATGCATGACAAACCCCTGGCTTTCCTGCCAGATGGTAGGACATGGACCTTGACCTGGGAAAG
CCATTACTCTTGTGTCTGCTACTGCCCTCCCACAGTCACCCCAATATTACAAGCACTGCCCCAGCGGCTTGATTTCCCCTCTGCCTTCCT
TCTCTCTGCACTCCCACAAAGCCAGGGCCAGGCTCCCCATCCCTACCTCCCACTGCATCAGCAGTGGGTGTTCCTGCCCTTCCTGAGTCT
AGGCAGCTCTGCTGCTGTGATCTGCACACCCTCCAACCTGGGCAGGGACTGGGGGGATGCAGTGTGTGTTAGTGCCCATGTGGCATTGTG
GCACTGTTGCCCCCCATGGCGGCATGGGCAAGATGACCTTCCATTAGCTTCAAGTCTTGTTCTCTTGTCTGTGGTCTGTTTAATATGTGG
GTCACTAGGGTATTTATTCTTTCTCCCATCCTTACACTCTGGATCATTGTGCAGACTTAATCAGGGTTTTAACGCTTTCATTTTTTTTTT
TTTTTTTTTTTTTTTGAGCTCAAAGAGAGTTCTCATTTTCCCTATTCAAACTAATACCCATGCCGTGTTTTTTACCTTGGATTTAAAGTC
ACCTTAGGTTGGGGCAACAGATTCTCACTCATGTTTAAGATCTTGTTATTTCAGCTTCATAAGATCAAAGAGGAGTCTTTCCCTTTTCTC
TTTTACCCTCAGGATTCTCATCCCTTACAGCTGACTCTTCCAGGCAATTTCCATAGATCTGCAGTCCTGCCTCTGCCACAGTCTCTCTGT

>In-frame_ENST00000606391_ENST00000361170_TCGA-EE-A3AD-06A_SHC1_chr1_154940680_-_IQGAP3_chr1_156498874_length(amino acids)=232AA_start in transcript=0_stop in transcript=698
MDLLPPKPKYNPLRNESLSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDIRNQHRHRHRRKAELVKLQA
TLQGLSTKTTFYEEQGDYYSQYIRACLDHLAPDSKSSGKGKKQPSLHYTAAQLLEKGVLVEIEDLPASHFRNVIFDITPGDEAGKFEVNA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SHC1-IQGAP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SHC1-IQGAP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SHC1-IQGAP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SHC1	C0018800	Cardiomegaly	1	CTD_human
Hgene	SHC1	C0019193	Hepatitis, Toxic	1	CTD_human
Hgene	SHC1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Hgene	SHC1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Hgene	SHC1	C1383860	Cardiac Hypertrophy	1	CTD_human
Hgene	SHC1	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
Hgene	SHC1	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
Hgene	SHC1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Hgene	SHC1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Hgene	SHC1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Hgene	SHC1	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human
Tgene	IQGAP3	C1510586	Autism Spectrum Disorders	1	CTD_human
Tgene	IQGAP3	C2239176	Liver carcinoma	1	CTD_human