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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:SHCBP1-ABCC12 (FusionGDB2 ID:81083) |
Fusion Gene Summary for SHCBP1-ABCC12 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SHCBP1-ABCC12 | Fusion gene ID: 81083 | Hgene | Tgene | Gene symbol | SHCBP1 | ABCC12 | Gene ID | 79801 | 94160 |
Gene name | SHC binding and spindle associated 1 | ATP binding cassette subfamily C member 12 | |
Synonyms | PAL | MRP9 | |
Cytomap | 16q11.2 | 16q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | SHC SH2 domain-binding protein 1Protein expressed in Activated Lymphocytes | multidrug resistance-associated protein 9ATP-binding cassette sub-family C member 12ATP-binding cassette transporter sub-family C member 12ATP-binding cassette, sub-family C (CFTR/MRP), member 12 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000303383, ENST00000564272, | ENST00000311303, ENST00000448542, ENST00000416054, ENST00000532355, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SHCBP1 [Title/Abstract] AND ABCC12 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | SHCBP1(46629464)-ABCC12(48172286), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across SHCBP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ABCC12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A2-A04U-01A | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
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Fusion Gene ORF analysis for SHCBP1-ABCC12 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000303383 | ENST00000311303 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
In-frame | ENST00000303383 | ENST00000448542 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
In-frame | ENST00000303383 | ENST00000416054 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
5CDS-intron | ENST00000303383 | ENST00000532355 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
intron-3CDS | ENST00000564272 | ENST00000311303 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
intron-3CDS | ENST00000564272 | ENST00000448542 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
intron-3CDS | ENST00000564272 | ENST00000416054 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
intron-intron | ENST00000564272 | ENST00000532355 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000303383 | SHCBP1 | chr16 | 46629464 | - | ENST00000311303 | ABCC12 | chr16 | 48172286 | - | 5722 | 1731 | 180 | 4979 | 1599 |
ENST00000303383 | SHCBP1 | chr16 | 46629464 | - | ENST00000448542 | ABCC12 | chr16 | 48172286 | - | 4793 | 1731 | 180 | 3707 | 1175 |
ENST00000303383 | SHCBP1 | chr16 | 46629464 | - | ENST00000416054 | ABCC12 | chr16 | 48172286 | - | 4947 | 1731 | 180 | 2801 | 873 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000303383 | ENST00000311303 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - | 0.00048231 | 0.9995177 |
ENST00000303383 | ENST00000448542 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - | 0.000879343 | 0.99912065 |
ENST00000303383 | ENST00000416054 | SHCBP1 | chr16 | 46629464 | - | ABCC12 | chr16 | 48172286 | - | 0.001165357 | 0.99883467 |
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Fusion Genomic Features for SHCBP1-ABCC12 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SHCBP1-ABCC12 |
Go to FGviewer for the breakpoints of chr16:46629464-chr16:48172286 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 211_216 | 488.0 | 673.0 | Compositional bias | Note=Poly-Glu |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 428_451 | 488.0 | 673.0 | Repeat | Note=PbH1 1 |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 452_473 | 488.0 | 673.0 | Repeat | Note=PbH1 2 |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 1120_1354 | 277.0 | 1360.0 | Domain | ABC transporter 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 467_701 | 277.0 | 1360.0 | Domain | ABC transporter 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 795_1082 | 277.0 | 1360.0 | Domain | ABC transmembrane type-1 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 1120_1354 | 277.0 | 612.6666666666666 | Domain | ABC transporter 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 467_701 | 277.0 | 612.6666666666666 | Domain | ABC transporter 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 795_1082 | 277.0 | 612.6666666666666 | Domain | ABC transmembrane type-1 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 1120_1354 | 277.0 | 885.6666666666666 | Domain | ABC transporter 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 467_701 | 277.0 | 885.6666666666666 | Domain | ABC transporter 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 795_1082 | 277.0 | 885.6666666666666 | Domain | ABC transmembrane type-1 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 1154_1161 | 277.0 | 1360.0 | Nucleotide binding | ATP 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 513_520 | 277.0 | 1360.0 | Nucleotide binding | ATP 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 1154_1161 | 277.0 | 612.6666666666666 | Nucleotide binding | ATP 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 513_520 | 277.0 | 612.6666666666666 | Nucleotide binding | ATP 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 1154_1161 | 277.0 | 885.6666666666666 | Nucleotide binding | ATP 2 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 513_520 | 277.0 | 885.6666666666666 | Nucleotide binding | ATP 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 1031_1051 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 348_368 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 376_396 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 791_811 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 853_873 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 934_954 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 1031_1051 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 348_368 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 376_396 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 791_811 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 853_873 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 934_954 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 1031_1051 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 348_368 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 376_396 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 791_811 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 853_873 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 934_954 | 277.0 | 885.6666666666666 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 474_496 | 488.0 | 673.0 | Repeat | Note=PbH1 3 |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 497_518 | 488.0 | 673.0 | Repeat | Note=PbH1 4 |
Hgene | SHCBP1 | chr16:46629464 | chr16:48172286 | ENST00000303383 | - | 10 | 13 | 526_548 | 488.0 | 673.0 | Repeat | Note=PbH1 5 |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 123_403 | 277.0 | 1360.0 | Domain | ABC transmembrane type-1 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 123_403 | 277.0 | 612.6666666666666 | Domain | ABC transmembrane type-1 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 123_403 | 277.0 | 885.6666666666666 | Domain | ABC transmembrane type-1 1 | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 125_145 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 159_179 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 231_251 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000311303 | 4 | 29 | 256_276 | 277.0 | 1360.0 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 125_145 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 159_179 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 231_251 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000416054 | 4 | 28 | 256_276 | 277.0 | 612.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 125_145 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 159_179 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 231_251 | 277.0 | 885.6666666666666 | Transmembrane | Helical | |
Tgene | ABCC12 | chr16:46629464 | chr16:48172286 | ENST00000448542 | 4 | 28 | 256_276 | 277.0 | 885.6666666666666 | Transmembrane | Helical |
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Fusion Gene Sequence for SHCBP1-ABCC12 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000303383_ENST00000311303_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(transcript)=5722nt_BP=1731nt TATCTCATTTCCAGGCATTGCTGGTTCGTTTTTTTCGAAAATCATTCCAAATTATATTCCAATTCGACTTTCTTCAAGTTCATCCCAGAA AAGCAAAGGCCGGGCACTTGAACAAGAACAGCTGTCAGCCTGGGGCGAGGGGGCAGTGTTGGTGGGGGCTGGAGCGGGGCCGGACTCTAA TTGGTCCACGGCCTCGGCCCGACTATCAAATCAGCAGAGCCTGCGTCATCACGTCGTTGCCTGGGCTGCCGTCCGCGGAAATTTGAAATG GCTGACGGGTCGCTGACGGGCGGCGGTCTGGAGGCAGCGGCCATGGCGCCGGAGCGCATGGGCTGGGCGGTGGAGCAGGAGCTGGCGTCT CTGGAGAAAGGTTTGTTCCAAGATGAAGATTCATGCAGTGATTGTAGCTACCGTGATAAACCAGGTTCTAGTTTACAAAGTTTTATGCCA GAAGGAAAAACCTTTTTCCCAGAAATTTTCCAAACAAATCAACTTTTGTTCTATGAGCGATTCAGAGCCTATCAAGATTACATTTTAGCT GACTGCAAGGCCTCTGAGGTACAGGAATTCACAGCTGAGTTCTTGGAGAAGGTCCTTGAGCCATCTGGATGGCGGGCAGTCTGGCACACT AATGTGTTCAAGGTGCTGGTTGAGATCACAGATGTGGACTTTGCAGCCTTGAAGGCAGTGGTGAGGCTTGCTGAACCATACCTCTGTGAC TCTCAAGTGAGCACTTTTACCATGGAGTGCATGAAGGAGCTCCTTGATCTGAAGGAGCATCGGTTGCCCCTGCAGGAGCTGTGGGTGGTG TTTGATGATTCAGGAGTGTTTGACCAGACAGCCCTTGCAATTGAGCATGTCAGATTTTTCTACCAAAACATTTGGAGGAGTTGGGATGAA GAAGAGGAGGATGAATACGATTATTTTGTCAGATGTGTTGAACCTCGATTAAGATTGCATTATGACATTCTTGAAGACCGAGTTCCATCA GGACTTATTGTTGACTACCACAATCTGTTGTCTCAATGTGAGGAGAGTTACAGGAAATTTTTAAATCTGAGAAGCAGTTTGTCAAATTGT AACTCTGATTCCGAGCAGGAAAATATCTCCATGGTGGAAGGGTTAAAATTGTATTCGGAGATGGAACAGTTGAAACAAAAGCTGAAACTC ATTGAGAATCCTTTGTTGAGGTATGTGTTTGGTTATCAGAAGAATTCTAACATCCAAGCAAAGGGTGTCCGTTCCAGCGGTCAGAAGATC ACTCATGTGGTCTCCTCCACCATGATGGCTGGTCTCCTGCGGTCCCTGCTTACGGACAGGCTTTGCCAGGAGCCTGGTGAGGAAGAAAGA GAAATTCAGTTCCATAGTGATCCATTGTCTGCTATAAATGCCTGCTTCGAAGGTGACACTGTTATTGTTTGTCCTGGCCATTATGTGGTA CATGGCACTTTCTCCATTGCTGACTCCATTGAGTTGGAAGGATATGGCCTACCAGATGACATTGTGATAGAAAAGAGGGGCAAAGGCGAC ACTTTTGTGGACTGCACTGGTGCTGATATTAAAATCTCAGGCATAAAATTTGTTCAGCATGATGCTGTAGAGGGAATCTTAATTGTTCAC CGTGGTAAGACTACGCTGGAAAACTGTGTGCTGCAGTGTGAGACGACCGGAGTCACAGTGCGGACATCAGCAGAGTTTCTAATGAAGAAC TCGGATTTATATGGCGCCAAGATGTTTATGGCCAAGCTCAATTCAGCTTTCCGAAGGTCAGCAATTTTGGTGACAGACAAGCGAGTTCAG ACAATGAATGAGTTTCTGACCTGCATCAGGCTGATCAAAATGTATGCCTGGGAGAAATCTTTTACCAACACTATCCAAGATATAAGAAGG AGGGAAAGAAAATTACTGGAAAAAGCTGGATTTGTCCAAAGTGGAAACTCTGCCCTGGCCCCCATCGTGTCCACCATAGCCATCGTGCTG ACATTATCCTGCCACATCCTCCTGAGACGCAAACTCACCGCACCCGTGGCATTTAGTGTGATTGCCATGTTTAATGTAATGAAGTTTTCC ATTGCAATCTTGCCCTTCTCCATCAAAGCAATGGCTGAAGCGAATGTCTCTCTAAGGAGAATGAAGAAAATTCTCATAGATAAAAGCCCC CCATCTTACATCACCCAACCAGAAGACCCAGATACTGTCTTGCTTTTAGCAAATGCCACCTTGACATGGGAGCATGAAGCCAGCAGGAAA AGTACCCCAAAGAAATTGCAGAACCAGAAAAGGCATTTATGCAAGAAACAGAGGTCAGAGGCATACAGTGAGAGGAGTCCACCAGCCAAG GGAGCCACTGGCCCAGAGGAGCAAAGTGACAGCCTCAAATCGGTTCTGCACAGCATAAGCTTTGTGGTGAGAAAGGGGAAGATCTTGGGA ATATGTGGGAATGTGGGAAGTGGAAAGAGCTCCCTCCTTGCAGCTCTCCTAGGACAGATGCAGCTGCAGAAAGGGGTGGTGGCAGTCAAT GGAACTTTGGCCTACGTTTCACAGCAGGCATGGATCTTTCATGGAAATGTGAGAGAAAACATACTCTTTGGAGAAAAGTATGATCACCAA AGGTATCAGCACACAGTCCGCGTCTGTGGCCTCCAGAAGGACCTGAGCAACCTCCCCTATGGAGACCTGACTGAGATTGGGGAGCGGGGC CTCAACCTCTCTGGGGGGCAGAGGCAGAGGATTAGCCTGGCCCGCGCTGTCTACTCCGACCGTCAGCTCTACCTGCTGGACGACCCCCTG TCGGCCGTGGACGCCCACGTGGGGAAGCACGTCTTTGAGGAGTGCATTAAGAAGACGCTCAGGGGAAAGACAGTCGTCCTGGTGACCCAC CAGCTACAGTTCTTAGAGTCTTGTGATGAAGTTATTTTATTAGAAGATGGAGAGATTTGTGAAAAGGGAACCCACAAGGAGTTAATGGAG GAGAGAGGGCGCTATGCAAAACTGATTCACAACCTGCGAGGATTGCAGTTCAAGGATCCTGAACACCTTTACAATGCAGCAATGGTGGAA GCCTTCAAGGAGAGCCCTGCTGAGAGAGAGGAAGATGCTGGTATAATCGTTTTGGCTCCAGGAAATGAGAAAGATGAAGGAAAAGAATCT GAAACAGGCTCAGAATTTGTAGACACAAAAGTTCCTGAGCACCAGCTCATCCAGACTGAATCCCCCCAGGAAGGAACCGTGACCTGGAAA ACATATCACACGTACATTAAGGCTTCTGGAGGGTACCTCCTTTCTCTCTTCACTGTGTTCCTCTTCCTCCTGATGATTGGCAGCGCTGCC TTCAGCAACTGGTGGCTGGGTCTCTGGTTGGACAAGGGCTCACGGATGACCTGTGGGCCCCAGGGCAACAGGACCATGTGTGAGGTCGGC GCGGTGCTGGCAGACATCGGTCAGCATGTGTACCAGTGGGTGTACACTGCAAGCATGGTGTTCATGCTGGTGTTTGGCGTCACCAAAGGC TTCGTCTTCACCAAGACCACACTGATGGCATCCTCCTCTCTGCATGACACGGTGTTTGATAAGATCTTAAAGAGCCCAATGAGTTTCTTT GACACGACTCCCACTGGCAGGCTAATGAACCGTTTTTCCAAGGATATGGACGAGCTGGATGTGAGGCTGCCGTTTCACGCAGAGAACTTT CTGCAGCAGTTTTTTATGGTGGTGTTTATTCTCGTGATCTTGGCTGCTGTGTTTCCTGCTGTCCTTTTAGTCGTGGCCAGCCTTGCTGTA GGCTTCTTCATTCTGTTACGCATTTTCCACAGAGGAGTCCAGGAGCTCAAGAAGGTGGAGAATGTCAGCCGGTCACCCTGGTTCACCCAC ATCACCTCCTCCATGCAGGGCCTGGGCATCATTCACGCCTATGGCAAGAAGGAGAGCTGCATCACCTATCACCTCCTCTACTTTAACTGT GCTCTCAGGTGGTTTGCGCTGAGAATGGATGTCCTCATGAACATCCTTACCTTCACTGTGGCCTTGTTGGTGACCCTGAGTTTCTCCTCC ATCAGTACTTCATCCAAAGGCCTGTCATTGTCATACATCATCCAGCTGAGCGGACTGCTCCAAGTGTGTGTGCGAACGGGAACAGAGACG CAAGCCAAATTCACCTCCGTGGAGCTGCTCAGGGAATACATTTCGACCTGTGTTCCTGAATGCACTCATCCCCTCAAAGTGGGGACCTGT CCCAAGGACTGGCCCAGCCGTGGGGAGATCACCTTCAGAGACTATCAGATGAGATACAGAGACAACACCCCCCTTGTTCTCGACAGCCTG AACTTGAACATACAAAGTGGGCAGACAGTCGGGATTGTTGGAAGAACAGGTTCCGGAAAGTCATCGTTAGGAATGGCTTTGTTTCGTCTG GTGGAGCCAGCCAGTGGCACAATCTTTATTGATGAGGTGGATATCTGCATTCTCAGCTTGGAAGACCTCAGAACCAAGCTGACTGTGATC CCACAGGATCCTGTCCTGTTTGTAGGTACAGTAAGGTACAACTTGGATCCCTTTGAGAGTCACACCGATGAGATGCTCTGGCAGGTTCTG GAGAGAACATTCATGAGAGACACAATAATGAAACTCCCAGAAAAATTACAGGCAGAAGTCACAGAAAATGGAGAAAACTTCTCAGTAGGG GAACGTCAGCTGCTTTGTGTGGCCCGAGCTCTTCTCCGTAATTCAAAGATCATTCTCCTTGATGAAGCCACCGCCTCTATGGACTCCAAG ACTGACACCCTGGTTCAGAACACCATCAAAGATGCCTTCAAGGGCTGCACTGTGCTGACCATCGCCCACCGCCTCAACACAGTTCTCAAC TGCGATCACGTCCTGGTTATGGAAAATGGGAAGGTGATTGAGTTTGACAAGCCTGAAGTCCTTGCAGAGAAGCCAGATTCTGCATTTGCG ATGTTACTAGCAGCAGAAGTCAGATTGTAGAGGTCCTGGCGGCTGATTCTAGAGGAGGAAGAGGCTCTGTGAGATGAATAGGAGGAGTCT TCAGGAGGAGGGGCTGTCCTCTCCGCAGGCAGCCCTGGTCTTCAGCCCCTCCCATCCACGGAGTGAGCTGGGGCTGAAGTTGTCCCCACT GCCATACTCAGTCCATGTCACCCCACTTGGTGGGCTTGGGGTTGGTTCTGGGTGGTGAACCGGGGCAGACCCAGCTAATGGATTAAAAAA CTGCCCTTCACCTCCCAAATCCCCAAGGGTTCCTCATGTGTTTTCACCAAAACCACCCCAGTGCCTGAGATTGAAAATATTGTAACTTTC AGTTAGAAATCAGCCACAATAAACAACATGGGAAAATGCCTTAGGATGGAGTTTGCAAGGTTTCCTTGCCCATTATCAGAAGGAAAAAGA GCAGAATTTTCTTCTCGTTTAACCCCACTCACTTCCATCTTGACTGGGTGACAAGTGGTAATGACACAGATTTGTAGCGTGAAAGACTGA ATACAGTGTTTGGCCAAAAATTTTTTTAAAAATCATATTATATGTTTCAATTGATCTGTTAGAATAACCAAGAAAACAAAATGCTGGAGT TTCTCTATAAATGACACTTTTATATCTTCTTTATTCGTCGTTAAAACGCGGTAGGAAATTACCCTGAAATGTCGCCTTGCAATTATTTCA >In-frame_ENST00000303383_ENST00000311303_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(amino acids)=1599AA_start in transcript=180_stop in transcript=4979 MVHGLGPTIKSAEPASSRRCLGCRPRKFEMADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMP EGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCD SQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPS GLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKI THVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGD TFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKMFMAKLNSAFRRSAILVTDKRVQ TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFS IAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQ RYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAGIIVLAPGNEKDEGKES ETGSEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVG AVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENF LQQFFMVVFILVILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKKESCITYHLLYFNC ALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKVGTC PKDWPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDEATASMDSK -------------------------------------------------------------- >In-frame_ENST00000303383_ENST00000448542_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(transcript)=4793nt_BP=1731nt TATCTCATTTCCAGGCATTGCTGGTTCGTTTTTTTCGAAAATCATTCCAAATTATATTCCAATTCGACTTTCTTCAAGTTCATCCCAGAA AAGCAAAGGCCGGGCACTTGAACAAGAACAGCTGTCAGCCTGGGGCGAGGGGGCAGTGTTGGTGGGGGCTGGAGCGGGGCCGGACTCTAA TTGGTCCACGGCCTCGGCCCGACTATCAAATCAGCAGAGCCTGCGTCATCACGTCGTTGCCTGGGCTGCCGTCCGCGGAAATTTGAAATG GCTGACGGGTCGCTGACGGGCGGCGGTCTGGAGGCAGCGGCCATGGCGCCGGAGCGCATGGGCTGGGCGGTGGAGCAGGAGCTGGCGTCT CTGGAGAAAGGTTTGTTCCAAGATGAAGATTCATGCAGTGATTGTAGCTACCGTGATAAACCAGGTTCTAGTTTACAAAGTTTTATGCCA GAAGGAAAAACCTTTTTCCCAGAAATTTTCCAAACAAATCAACTTTTGTTCTATGAGCGATTCAGAGCCTATCAAGATTACATTTTAGCT GACTGCAAGGCCTCTGAGGTACAGGAATTCACAGCTGAGTTCTTGGAGAAGGTCCTTGAGCCATCTGGATGGCGGGCAGTCTGGCACACT AATGTGTTCAAGGTGCTGGTTGAGATCACAGATGTGGACTTTGCAGCCTTGAAGGCAGTGGTGAGGCTTGCTGAACCATACCTCTGTGAC TCTCAAGTGAGCACTTTTACCATGGAGTGCATGAAGGAGCTCCTTGATCTGAAGGAGCATCGGTTGCCCCTGCAGGAGCTGTGGGTGGTG TTTGATGATTCAGGAGTGTTTGACCAGACAGCCCTTGCAATTGAGCATGTCAGATTTTTCTACCAAAACATTTGGAGGAGTTGGGATGAA GAAGAGGAGGATGAATACGATTATTTTGTCAGATGTGTTGAACCTCGATTAAGATTGCATTATGACATTCTTGAAGACCGAGTTCCATCA GGACTTATTGTTGACTACCACAATCTGTTGTCTCAATGTGAGGAGAGTTACAGGAAATTTTTAAATCTGAGAAGCAGTTTGTCAAATTGT AACTCTGATTCCGAGCAGGAAAATATCTCCATGGTGGAAGGGTTAAAATTGTATTCGGAGATGGAACAGTTGAAACAAAAGCTGAAACTC ATTGAGAATCCTTTGTTGAGGTATGTGTTTGGTTATCAGAAGAATTCTAACATCCAAGCAAAGGGTGTCCGTTCCAGCGGTCAGAAGATC ACTCATGTGGTCTCCTCCACCATGATGGCTGGTCTCCTGCGGTCCCTGCTTACGGACAGGCTTTGCCAGGAGCCTGGTGAGGAAGAAAGA GAAATTCAGTTCCATAGTGATCCATTGTCTGCTATAAATGCCTGCTTCGAAGGTGACACTGTTATTGTTTGTCCTGGCCATTATGTGGTA CATGGCACTTTCTCCATTGCTGACTCCATTGAGTTGGAAGGATATGGCCTACCAGATGACATTGTGATAGAAAAGAGGGGCAAAGGCGAC ACTTTTGTGGACTGCACTGGTGCTGATATTAAAATCTCAGGCATAAAATTTGTTCAGCATGATGCTGTAGAGGGAATCTTAATTGTTCAC CGTGGTAAGACTACGCTGGAAAACTGTGTGCTGCAGTGTGAGACGACCGGAGTCACAGTGCGGACATCAGCAGAGTTTCTAATGAAGAAC TCGGATTTATATGGCGCCAAGATGTTTATGGCCAAGCTCAATTCAGCTTTCCGAAGGTCAGCAATTTTGGTGACAGACAAGCGAGTTCAG ACAATGAATGAGTTTCTGACCTGCATCAGGCTGATCAAAATGTATGCCTGGGAGAAATCTTTTACCAACACTATCCAAGATATAAGAAGG AGGGAAAGAAAATTACTGGAAAAAGCTGGATTTGTCCAAAGTGGAAACTCTGCCCTGGCCCCCATCGTGTCCACCATAGCCATCGTGCTG ACATTATCCTGCCACATCCTCCTGAGACGCAAACTCACCGCACCCGTGGCATTTAGTGTGATTGCCATGTTTAATGTAATGAAGTTTTCC ATTGCAATCTTGCCCTTCTCCATCAAAGCAATGGCTGAAGCGAATGTCTCTCTAAGGAGAATGAAGAAAATTCTCATAGATAAAAGCCCC CCATCTTACATCACCCAACCAGAAGACCCAGATACTGTCTTGCTTTTAGCAAATGCCACCTTGACATGGGAGCATGAAGCCAGCAGGAAA AGTACCCCAAAGAAATTGCAGAACCAGAAAAGGCATTTATGCAAGAAACAGAGGTCAGAGGCATACAGTGAGAGGAGTCCACCAGCCAAG GGAGCCACTGGCCCAGAGGAGCAAAGTGACAGCCTCAAATCGGTTCTGCACAGCATAAGCTTTGTGGTGAGAAAGGGGAAGATCTTGGGA ATATGTGGGAATGTGGGAAGTGGAAAGAGCTCCCTCCTTGCAGCTCTCCTAGGACAGATGCAGCTGCAGAAAGGGGTGGTGGCAGTCAAT GGAACTTTGGCCTACGTTTCACAGCAGGCATGGATCTTTCATGGAAATGTGAGAGAAAACATACTCTTTGGAGAAAAGTATGATCACCAA AGGTATCAGCACACAGTCCGCGTCTGTGGCCTCCAGAAGGACCTGAGCAACCTCCCCTATGGAGACCTGACTGAGATTGGGGAGCGGGGC CTCAACCTCTCTGGGGGGCAGAGGCAGAGGATTAGCCTGGCCCGCGCTGTCTACTCCGACCGTCAGCTCTACCTGCTGGACGACCCCCTG TCGGCCGTGGACGCCCACGTGGGGAAGCACGTCTTTGAGGAGTGCATTAAGAAGACGCTCAGGGGAAAGACAGTCGTCCTGGTGACCCAC CAGCTACAGTTCTTAGAGTCTTGTGATGAAGTTATTTTATTAGAAGATGGAGAGATTTGTGAAAAGGGAACCCACAAGGAGTTAATGGAG GAGAGAGGGCGCTATGCAAAACTGATTCACAACCTGCGAGGATTGCAGTTCAAGGATCCTGAACACCTTTACAATGCAGCAATGGTGGAA GCCTTCAAGGAGAGCCCTGCTGAGAGAGAGGAAGATGCTGTTTTGGCTCCAGGAAATGAGAAAGATGAAGGAAAAGAATCTGAAACAGGC TCAGAATTTGTAGACACAAAAGTTCCTGAGCACCAGCTCATCCAGACTGAATCCCCCCAGGAAGGAACCGTGACCTGGAAAACATATCAC ACGTACATTAAGGCTTCTGGAGGGTACCTCCTTTCTCTCTTCACTGTGTTCCTCTTCCTCCTGATGATTGGCAGCGCTGCCTTCAGCAAC TGGTGGCTGGGTCTCTGGTTGGACAAGGGCTCACGGATGACCTGTGGGCCCCAGGGCAACAGGACCATGTGTGAGGTCGGCGCGGTGCTG GCAGACATCGGTCAGCATGTGTACCAGTGGGTGTACACTGCAAGCATGGTGTTCATGCTGGTGTTTGGCGTCACCAAAGGCTTCGTCTTC ACCAAGACCACACTGATGGCATCCTCCTCTCTGCATGACACGGTGTTTGATAAGCATTTTCCACAGAGGAGTCCAGGAGCTCAAGAAGGT GGAGAATGTCAGCCGGTCACCCTGGTTCACCCACATCACCTCCTCCATGCAGGGCCTGGGCATCATTCACGCCTATGGCAAGAAGGAGAG CTGCATCACCTAGTTTAAGACGCTAAACGACGAAAACTCCAGTCACCTCCTCTACTTTAACTGTGCTCTCAGGTGGTTTGCGCTGAGAAT GGATGTCCTCATGAACATCCTTACCTTCACTGTGGCCTTGTTGGTGACCCTGAGTTTCTCCTCCATCAGTACTTCATCCAAAGGCCTGTC ATTGTCATACATCATCCAGCTGAGCGGACTGCTCCAAGTGTGTGTGCGAACGGGAACAGAGACGCAAGCCAAATTCACCTCCGTGGAGCT GCTCAGGGAATACATTTCGACCTGTGTTCCTGAATGCACTCATCCCCTCAAAGTGGGGACCTGTCCCAAGGACTGGCCCAGCCGTGGGGA GATCACCTTCAGAGACTATCAGATGAGATACAGAGACAACACCCCCCTTGTTCTCGACAGCCTGAACTTGAACATACAAAGTGGGCAGAC AGTCGGGATTGTTGGAAGAACAGGTTCCGGAAAGTCATCGTTAGGAATGGCTTTGTTTCGTCTGGTGGAGCCAGCCAGTGGCACAATCTT TATTGATGAGGTGGATATCTGCATTCTCAGCTTGGAAGACCTCAGAACCAAGCTGACTGTGATCCCACAGGATCCTGTCCTGTTTGTAGG TACAGTAAGGTACAACTTGGATCCCTTTGAGAGTCACACCGATGAGATGCTCTGGCAGGTTCTGGAGAGAACATTCATGAGAGACACAAT AATGAAACTCCCAGAAAAATTACAGGCAGAAGTCACAGAAAATGGAGAAAACTTCTCAGTAGGGGAACGTCAGCTGCTTTGTGTGGCCCG AGCTCTTCTCCGTAATTCAAAGATCATTCTCCTTGATGAAGCCACCGCCTCTATGGACTCCAAGACTGACACCCTGGTTCAGAACACCAT CAAAGATGCCTTCAAGGGCTGCACTGTGCTGACCATCGCCCACCGCCTCAACACAGTTCTCAACTGCGATCACGTCCTGGTTATGGAAAA TGGGAAGGTGATTGAGTTTGACAAGCCTGAAGTCCTTGCAGAGAAGCCAGATTCTGCATTTGCGATGTTACTAGCAGCAGAAGTCAGATT >In-frame_ENST00000303383_ENST00000448542_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(amino acids)=1175AA_start in transcript=180_stop in transcript=3707 MVHGLGPTIKSAEPASSRRCLGCRPRKFEMADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMP EGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCD SQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPS GLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKI THVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGD TFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKMFMAKLNSAFRRSAILVTDKRVQ TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFS IAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQ RYQHTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAMVEAFKESPAEREEDAVLAPGNEKDEGKESETG SEFVDTKVPEHQLIQTESPQEGTVTWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMCEVGAVL ADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKHFPQRSPGAQEGGECQPVTLVHPHHLLHAGPGHHSRLWQEGE -------------------------------------------------------------- >In-frame_ENST00000303383_ENST00000416054_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(transcript)=4947nt_BP=1731nt TATCTCATTTCCAGGCATTGCTGGTTCGTTTTTTTCGAAAATCATTCCAAATTATATTCCAATTCGACTTTCTTCAAGTTCATCCCAGAA AAGCAAAGGCCGGGCACTTGAACAAGAACAGCTGTCAGCCTGGGGCGAGGGGGCAGTGTTGGTGGGGGCTGGAGCGGGGCCGGACTCTAA TTGGTCCACGGCCTCGGCCCGACTATCAAATCAGCAGAGCCTGCGTCATCACGTCGTTGCCTGGGCTGCCGTCCGCGGAAATTTGAAATG GCTGACGGGTCGCTGACGGGCGGCGGTCTGGAGGCAGCGGCCATGGCGCCGGAGCGCATGGGCTGGGCGGTGGAGCAGGAGCTGGCGTCT CTGGAGAAAGGTTTGTTCCAAGATGAAGATTCATGCAGTGATTGTAGCTACCGTGATAAACCAGGTTCTAGTTTACAAAGTTTTATGCCA GAAGGAAAAACCTTTTTCCCAGAAATTTTCCAAACAAATCAACTTTTGTTCTATGAGCGATTCAGAGCCTATCAAGATTACATTTTAGCT GACTGCAAGGCCTCTGAGGTACAGGAATTCACAGCTGAGTTCTTGGAGAAGGTCCTTGAGCCATCTGGATGGCGGGCAGTCTGGCACACT AATGTGTTCAAGGTGCTGGTTGAGATCACAGATGTGGACTTTGCAGCCTTGAAGGCAGTGGTGAGGCTTGCTGAACCATACCTCTGTGAC TCTCAAGTGAGCACTTTTACCATGGAGTGCATGAAGGAGCTCCTTGATCTGAAGGAGCATCGGTTGCCCCTGCAGGAGCTGTGGGTGGTG TTTGATGATTCAGGAGTGTTTGACCAGACAGCCCTTGCAATTGAGCATGTCAGATTTTTCTACCAAAACATTTGGAGGAGTTGGGATGAA GAAGAGGAGGATGAATACGATTATTTTGTCAGATGTGTTGAACCTCGATTAAGATTGCATTATGACATTCTTGAAGACCGAGTTCCATCA GGACTTATTGTTGACTACCACAATCTGTTGTCTCAATGTGAGGAGAGTTACAGGAAATTTTTAAATCTGAGAAGCAGTTTGTCAAATTGT AACTCTGATTCCGAGCAGGAAAATATCTCCATGGTGGAAGGGTTAAAATTGTATTCGGAGATGGAACAGTTGAAACAAAAGCTGAAACTC ATTGAGAATCCTTTGTTGAGGTATGTGTTTGGTTATCAGAAGAATTCTAACATCCAAGCAAAGGGTGTCCGTTCCAGCGGTCAGAAGATC ACTCATGTGGTCTCCTCCACCATGATGGCTGGTCTCCTGCGGTCCCTGCTTACGGACAGGCTTTGCCAGGAGCCTGGTGAGGAAGAAAGA GAAATTCAGTTCCATAGTGATCCATTGTCTGCTATAAATGCCTGCTTCGAAGGTGACACTGTTATTGTTTGTCCTGGCCATTATGTGGTA CATGGCACTTTCTCCATTGCTGACTCCATTGAGTTGGAAGGATATGGCCTACCAGATGACATTGTGATAGAAAAGAGGGGCAAAGGCGAC ACTTTTGTGGACTGCACTGGTGCTGATATTAAAATCTCAGGCATAAAATTTGTTCAGCATGATGCTGTAGAGGGAATCTTAATTGTTCAC CGTGGTAAGACTACGCTGGAAAACTGTGTGCTGCAGTGTGAGACGACCGGAGTCACAGTGCGGACATCAGCAGAGTTTCTAATGAAGAAC TCGGATTTATATGGCGCCAAGATGTTTATGGCCAAGCTCAATTCAGCTTTCCGAAGGTCAGCAATTTTGGTGACAGACAAGCGAGTTCAG ACAATGAATGAGTTTCTGACCTGCATCAGGCTGATCAAAATGTATGCCTGGGAGAAATCTTTTACCAACACTATCCAAGATATAAGAAGG AGGGAAAGAAAATTACTGGAAAAAGCTGGATTTGTCCAAAGTGGAAACTCTGCCCTGGCCCCCATCGTGTCCACCATAGCCATCGTGCTG ACATTATCCTGCCACATCCTCCTGAGACGCAAACTCACCGCACCCGTGGCATTTAGTGTGATTGCCATGTTTAATGTAATGAAGTTTTCC ATTGCAATCTTGCCCTTCTCCATCAAAGCAATGGCTGAAGCGAATGTCTCTCTAAGGAGAATGAAGAAAATTCTCATAGATAAAAGCCCC CCATCTTACATCACCCAACCAGAAGACCCAGATACTGTCTTGCTTTTAGCAAATGCCACCTTGACATGGGAGCATGAAGCCAGCAGGAAA AGTACCCCAAAGAAATTGCAGAACCAGAAAAGGCATTTATGCAAGAAACAGAGGTCAGAGGCATACAGTGAGAGGAGTCCACCAGCCAAG GGAGCCACTGGCCCAGAGGAGCAAAGTGACAGCCTCAAATCGGTTCTGCACAGCATAAGCTTTGTGGTGAGAAAGGGGAAGATCTTGGGA ATATGTGGGAATGTGGGAAGTGGAAAGAGCTCCCTCCTTGCAGCTCTCCTAGGACAGATGCAGCTGCAGAAAGGGGTGGTGGCAGTCAAT GGAACTTTGGCCTACGTTTCACAGCAGGCATGGATCTTTCATGGAAATGTGAGAGAAAACATACTCTTTGGAGAAAAGTATGATCACCAA AGATTGGGGAGCGGGGCCTCAACCTCTCTGGGGGGCAGAGGCAGAGGATTAGCCTGGCCCGCGCTGTCTACTCCGACCGTCAGCTCTACC TGCTGGACGACCCCCTGTCGGCCGTGGACGCCCACGTGGGGAAGCACGTCTTTGAGGAGTGCATTAAGAAGACGCTCAGGGGAAAGACAG TCGTCCTGGTGACCCACCAGCTACAGTTCTTAGAGTCTTGTGATGAAGTTATTTTATTAGAAGATGGAGAGATTTGTGAAAAGGGAACCC ACAAGGAGTTAATGGAGGAGAGAGGGCGCTATGCAAAACTGATTCACAACCTGCGAGGATTGCAGTTCAAGGATCCTGAACACCTTTACA ATGCAGCAATGGTGGAAGCCTTCAAGGAGAGCCCTGCTGAGAGAGAGGAAGATGCTGTTTTGGCTCCAGGAAATGAGAAAGATGAAGGAA AAGAATCTGAAACAGGCTCAGAATTTGTAGACACAAAAGTTCCTGAGCACCAGCTCATCCAGACTGAATCCCCCCAGGAAGGAACCGTGA CCTGGAAAACATATCACACGTACATTAAGGCTTCTGGAGGGTACCTCCTTTCTCTCTTCACTGTGTTCCTCTTCCTCCTGATGATTGGCA GCGCTGCCTTCAGCAACTGGTGGCTGGGTCTCTGGTTGGACAAGGGCTCACGGATGACCTGTGGGCCCCAGGGCAACAGGACCATGTGTG AGGTCGGCGCGGTGCTGGCAGACATCGGTCAGCATGTGTACCAGTGGGTGTACACTGCAAGCATGGTGTTCATGCTGGTGTTTGGCGTCA CCAAAGGCTTCGTCTTCACCAAGACCACACTGATGGCATCCTCCTCTCTGCATGACACGGTGTTTGATAAGATCTTAAAGAGCCCAATGA GTTTCTTTGACACGACTCCCACTGGCAGGCTAATGAACCGTTTTTCCAAGGATATGGACGAGCTGGATGTGAGGCTGCCGTTTCACGCAG AGAACTTTCTGCAGCAGTTTTTTATGGTGGTGTTTATTCTCGTGATCTTGGCTGCTGTGTTTCCTGCTGTCCTTTTAGTCGTGGCCAGCC TTGCTGTAGGCTTCTTCATTCTGTTACGCATTTTCCACAGAGGAGTCCAGGAGCTCAAGAAGGTGGAGAATGTCAGCCGGTCACCCTGGT TCACCCACATCACCTCCTCCATGCAGGGCCTGGGCATCATTCACGCCTATGGCAAGAAGGAGAGCTGCATCACCTAGTTTAAGACGCTAA ACGACGAAAACTCCAGTCACCTCCTCTACTTTAACTGTGCTCTCAGGTGGTTTGCGCTGAGAATGGATGTCCTCATGAACATCCTTACCT TCACTGTGGCCTTGTTGGTGACCCTGAGTTTCTCCTCCATCAGTACTTCATCCAAAGGCCTGTCATTGTCATACATCATCCAGCTGAGCG GACTGCTCCAAGTGTGTGTGCGAACGGGAACAGAGACGCAAGCCAAATTCACCTCCGTGGAGCTGCTCAGGGAATACATTTCGACCTGTG TTCCTGAATGCACTCATCCCCTCAAAGTGGGGACCTGTCCCAAGGACTGGCCCAGCCGTGGGGAGATCACCTTCAGAGACTATCAGATGA GATACAGAGACAACACCCCCCTTGTTCTCGACAGCCTGAACTTGAACATACAAAGTGGGCAGACAGTCGGGATTGTTGGAAGAACAGGTT CCGGAAAGTCATCGTTAGGAATGGCTTTGTTTCGTCTGGTGGAGCCAGCCAGTGGCACAATCTTTATTGATGAGGTGGATATCTGCATTC TCAGCTTGGAAGACCTCAGAACCAAGCTGACTGTGATCCCACAGGATCCTGTCCTGTTTGTAGGTACAGTAAGGTACAACTTGGATCCCT TTGAGAGTCACACCGATGAGATGCTCTGGCAGGTTCTGGAGAGAACATTCATGAGAGACACAATAATGAAACTCCCAGAAAAATTACAGG CAGAAGTCACAGAAAATGGAGAAAACTTCTCAGTAGGGGAACGTCAGCTGCTTTGTGTGGCCCGAGCTCTTCTCCGTAATTCAAAGATCA TTCTCCTTGATGAAGCCACCGCCTCTATGGACTCCAAGACTGACACCCTGGTTCAGAACACCATCAAAGATGCCTTCAAGGGCTGCACTG TGCTGACCATCGCCCACCGCCTCAACACAGTTCTCAACTGCGATCACGTCCTGGTTATGGAAAATGGGAAGGTGATTGAGTTTGACAAGC >In-frame_ENST00000303383_ENST00000416054_TCGA-A2-A04U-01A_SHCBP1_chr16_46629464_-_ABCC12_chr16_48172286_length(amino acids)=873AA_start in transcript=180_stop in transcript=2801 MVHGLGPTIKSAEPASSRRCLGCRPRKFEMADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCSDCSYRDKPGSSLQSFMP EGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFTAEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCD SQVSTFTMECMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPS GLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKI THVVSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGD TFVDCTGADIKISGIKFVQHDAVEGILIVHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKMFMAKLNSAFRRSAILVTDKRVQ TMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLTAPVAFSVIAMFNVMKFS IAILPFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTVLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAK GATGPEEQSDSLKSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SHCBP1-ABCC12 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SHCBP1-ABCC12 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SHCBP1-ABCC12 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SHCBP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SHCBP1 | C0039101 | synovial sarcoma | 1 | CTD_human |
Tgene | ABCC12 | C0005956 | Bone Marrow Diseases | 1 | CTD_human |
Tgene | ABCC12 | C0013221 | Drug toxicity | 1 | CTD_human |
Tgene | ABCC12 | C0041755 | Adverse reaction to drug | 1 | CTD_human |