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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIL1-NRG2 (FusionGDB2 ID:81317)

Fusion Gene Summary for SIL1-NRG2

check button Fusion gene summary
Fusion gene informationFusion gene name: SIL1-NRG2
Fusion gene ID: 81317
HgeneTgene
Gene symbol

SIL1

NRG2

Gene ID

64374

9542

Gene nameSIL1 nucleotide exchange factorneuregulin 2
SynonymsBAP|MSS|ULG5DON1|HRG2|NTAK
Cytomap

5q31.2

5q31.2

Type of geneprotein-codingprotein-coding
Descriptionnucleotide exchange factor SIL1BiP-associated proteinSIL1 homolog, endoplasmic reticulum chaperoneSIL1-like protein endoplasmic reticulum chaperonepro-neuregulin-2, membrane-bound isoformdivergent of neuregulin-1neural- and thymus-derived activator for ErbB kinasespro-NRG2
Modification date2020031320200313
UniProtAcc.

O14511

Ensembl transtripts involved in fusion geneENST00000394817, ENST00000265195, 
ENST00000509534, ENST00000515008, 
ENST00000541337, ENST00000289422, 
ENST00000361474, ENST00000545385, 
ENST00000394770, ENST00000358522, 
ENST00000289409, ENST00000340391, 
ENST00000518130, 
Fusion gene scores* DoF score14 X 11 X 10=15403 X 3 X 4=36
# samples 174
** MAII scorelog2(17/1540*10)=-3.17932369944456
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SIL1 [Title/Abstract] AND NRG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIL1(138456724)-NRG2(139267096), # samples:2
Anticipated loss of major functional domain due to fusion event.SIL1-NRG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SIL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NRG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H9-01ASIL1chr5

138456724

-NRG2chr5

139267096

-
ChimerDB4LIHCTCGA-EP-A2KA-01ASIL1chr5

138286860

-NRG2chr5

139267096

-
ChimerDB4BRCATCGA-BH-A0H9-01ASIL1chr5

138456724

-NRG2chr5

139267096

-


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Fusion Gene ORF analysis for SIL1-NRG2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000394817ENST00000541337SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000289422SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000361474SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000545385SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000394770SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000358522SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000289409SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000340391SIL1chr5

138456724

-NRG2chr5

139267096

-
5CDS-5UTRENST00000394817ENST00000518130SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000541337SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000289422SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000361474SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000545385SIL1chr5

138456724

-NRG2chr5

139267096

-
In-frameENST00000265195ENST00000394770SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000358522SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000289409SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000340391SIL1chr5

138456724

-NRG2chr5

139267096

-
5CDS-5UTRENST00000265195ENST00000518130SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000541337SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000289422SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000361474SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000545385SIL1chr5

138456724

-NRG2chr5

139267096

-
In-frameENST00000509534ENST00000394770SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000358522SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000289409SIL1chr5

138456724

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000340391SIL1chr5

138456724

-NRG2chr5

139267096

-
5CDS-5UTRENST00000509534ENST00000518130SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000541337SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000289422SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000361474SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000545385SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000394770SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000358522SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000289409SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-3CDSENST00000515008ENST00000340391SIL1chr5

138456724

-NRG2chr5

139267096

-
intron-5UTRENST00000515008ENST00000518130SIL1chr5

138456724

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000541337SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000289422SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000361474SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000545385SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000394817ENST00000394770SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000358522SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000289409SIL1chr5

138286860

-NRG2chr5

139267096

-
In-frameENST00000394817ENST00000340391SIL1chr5

138286860

-NRG2chr5

139267096

-
5CDS-5UTRENST00000394817ENST00000518130SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000541337SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000289422SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000361474SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000545385SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000394770SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000358522SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000289409SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000265195ENST00000340391SIL1chr5

138286860

-NRG2chr5

139267096

-
5CDS-5UTRENST00000265195ENST00000518130SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000541337SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000289422SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000361474SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000545385SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000394770SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000358522SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000289409SIL1chr5

138286860

-NRG2chr5

139267096

-
Frame-shiftENST00000509534ENST00000340391SIL1chr5

138286860

-NRG2chr5

139267096

-
5CDS-5UTRENST00000509534ENST00000518130SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000541337SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000289422SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000361474SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000545385SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000394770SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000358522SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000289409SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-3CDSENST00000515008ENST00000340391SIL1chr5

138286860

-NRG2chr5

139267096

-
5UTR-5UTRENST00000515008ENST00000518130SIL1chr5

138286860

-NRG2chr5

139267096

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265195SIL1chr5138456724-ENST00000394770NRG2chr5139267096-25443909222301459
ENST00000509534SIL1chr5138456724-ENST00000394770NRG2chr5139267096-263247810102389459
ENST00000394817SIL1chr5138286860-ENST00000541337NRG2chr5139267096-3962116911832823546
ENST00000394817SIL1chr5138286860-ENST00000289422NRG2chr5139267096-3314116911833045620
ENST00000394817SIL1chr5138286860-ENST00000361474NRG2chr5139267096-3264116911833021612
ENST00000394817SIL1chr5138286860-ENST00000545385NRG2chr5139267096-3270116911833027614
ENST00000394817SIL1chr5138286860-ENST00000358522NRG2chr5139267096-3028116911833027615
ENST00000394817SIL1chr5138286860-ENST00000289409NRG2chr5139267096-3004116911833003607
ENST00000394817SIL1chr5138286860-ENST00000340391NRG2chr5139267096-3022116911833021613

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265195ENST00000394770SIL1chr5138456724-NRG2chr5139267096-0.220214110.77978593
ENST00000509534ENST00000394770SIL1chr5138456724-NRG2chr5139267096-0.238109720.76189023
ENST00000394817ENST00000541337SIL1chr5138286860-NRG2chr5139267096-0.057931080.9420689
ENST00000394817ENST00000289422SIL1chr5138286860-NRG2chr5139267096-0.0490322370.9509677
ENST00000394817ENST00000361474SIL1chr5138286860-NRG2chr5139267096-0.0581332630.94186676
ENST00000394817ENST00000545385SIL1chr5138286860-NRG2chr5139267096-0.0501186140.94988143
ENST00000394817ENST00000358522SIL1chr5138286860-NRG2chr5139267096-0.061835810.9381642
ENST00000394817ENST00000289409SIL1chr5138286860-NRG2chr5139267096-0.0585532450.9414468
ENST00000394817ENST00000340391SIL1chr5138286860-NRG2chr5139267096-0.064376720.93562335

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Fusion Genomic Features for SIL1-NRG2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIL1-NRG2


check button Go to

FGviewer for the breakpoints of chr5:138456724-chr5:139267096

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NRG2

O14511

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010330_340233.33333333333334845.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010721_727233.33333333333334845.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011330_340233.33333333333334859.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011721_727233.33333333333334859.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010330_34030.333333333333332648.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST0000034039101033_4730.333333333333332648.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010721_72730.333333333333332648.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000034039101087_9030.333333333333332648.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011330_340233.33333333333334853.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011721_727233.33333333333334853.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010330_340233.33333333333334851.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010721_727233.33333333333334851.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011330_340233.33333333333334491.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011721_727233.33333333333334491.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010330_340233.33333333333334845.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010721_727233.33333333333334845.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011330_340233.33333333333334859.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011721_727233.33333333333334859.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010330_34030.333333333333332648.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST0000034039101033_4730.333333333333332648.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010721_72730.333333333333332648.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000034039101087_9030.333333333333332648.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011330_340233.33333333333334853.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011721_727233.33333333333334853.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010330_340233.33333333333334851.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010721_727233.33333333333334851.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011330_340233.33333333333334491.0Compositional biasNote=Ser/Thr-rich
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011721_727233.33333333333334491.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010237_332233.33333333333334845.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010341_382233.33333333333334845.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011237_332233.33333333333334859.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011341_382233.33333333333334859.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010237_33230.333333333333332648.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010341_38230.333333333333332648.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011237_332233.33333333333334853.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011341_382233.33333333333334853.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010237_332233.33333333333334851.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010341_382233.33333333333334851.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011237_332233.33333333333334491.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011341_382233.33333333333334491.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010237_332233.33333333333334845.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010341_382233.33333333333334845.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011237_332233.33333333333334859.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011341_382233.33333333333334859.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010237_33230.333333333333332648.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010341_38230.333333333333332648.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011237_332233.33333333333334853.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011341_382233.33333333333334853.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010237_332233.33333333333334851.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010341_382233.33333333333334851.0DomainEGF-like
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011237_332233.33333333333334491.0DomainNote=Ig-like C2-type
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011341_382233.33333333333334491.0DomainEGF-like
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010112_40530.333333333333332648.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010112_40530.333333333333332648.0Topological domainExtracellular
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010406_426233.33333333333334845.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011406_426233.33333333333334859.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138286860chr5:139267096ENST00000340391010406_42630.333333333333332648.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011406_426233.33333333333334853.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010406_426233.33333333333334851.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011406_426233.33333333333334491.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010406_426233.33333333333334845.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011406_426233.33333333333334859.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000340391010406_42630.333333333333332648.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011406_426233.33333333333334853.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010406_426233.33333333333334851.0TransmembraneHelical%3B Note%3DInternal signal sequence
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011406_426233.33333333333334491.0TransmembraneHelical%3B Note%3DInternal signal sequence

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNRG2chr5:138286860chr5:139267096ENST0000028940901010_13233.33333333333334845.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000028940901020_30233.33333333333334845.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000028940901033_47233.33333333333334845.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000028940901087_90233.33333333333334845.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST0000028942201110_13233.33333333333334859.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000028942201120_30233.33333333333334859.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000028942201133_47233.33333333333334859.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000028942201187_90233.33333333333334859.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST0000034039101010_1330.333333333333332648.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000034039101020_3030.333333333333332648.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000035852201110_13233.33333333333334853.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000035852201120_30233.33333333333334853.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000035852201133_47233.33333333333334853.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000035852201187_90233.33333333333334853.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST0000036147401010_13233.33333333333334851.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000036147401020_30233.33333333333334851.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000036147401033_47233.33333333333334851.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000036147401087_90233.33333333333334851.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST0000039477001110_13233.33333333333334491.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138286860chr5:139267096ENST0000039477001120_30233.33333333333334491.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000039477001133_47233.33333333333334491.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138286860chr5:139267096ENST0000039477001187_90233.33333333333334491.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST0000028940901010_13233.33333333333334845.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000028940901020_30233.33333333333334845.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000028940901033_47233.33333333333334845.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000028940901087_90233.33333333333334845.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST0000028942201110_13233.33333333333334859.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000028942201120_30233.33333333333334859.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000028942201133_47233.33333333333334859.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000028942201187_90233.33333333333334859.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST0000034039101010_1330.333333333333332648.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000034039101020_3030.333333333333332648.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000035852201110_13233.33333333333334853.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000035852201120_30233.33333333333334853.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000035852201133_47233.33333333333334853.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000035852201187_90233.33333333333334853.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST0000036147401010_13233.33333333333334851.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000036147401020_30233.33333333333334851.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000036147401033_47233.33333333333334851.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000036147401087_90233.33333333333334851.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138456724chr5:139267096ENST0000039477001110_13233.33333333333334491.0Compositional biasNote=Poly-Pro
TgeneNRG2chr5:138456724chr5:139267096ENST0000039477001120_30233.33333333333334491.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000039477001133_47233.33333333333334491.0Compositional biasNote=Poly-Ser
TgeneNRG2chr5:138456724chr5:139267096ENST0000039477001187_90233.33333333333334491.0Compositional biasNote=Poly-Ala
TgeneNRG2chr5:138286860chr5:139267096ENST00000289409010112_405233.33333333333334845.0Topological domainExtracellular
TgeneNRG2chr5:138286860chr5:139267096ENST00000289422011112_405233.33333333333334859.0Topological domainExtracellular
TgeneNRG2chr5:138286860chr5:139267096ENST00000358522011112_405233.33333333333334853.0Topological domainExtracellular
TgeneNRG2chr5:138286860chr5:139267096ENST00000361474010112_405233.33333333333334851.0Topological domainExtracellular
TgeneNRG2chr5:138286860chr5:139267096ENST00000394770011112_405233.33333333333334491.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000289409010112_405233.33333333333334845.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000289422011112_405233.33333333333334859.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000358522011112_405233.33333333333334853.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000361474010112_405233.33333333333334851.0Topological domainExtracellular
TgeneNRG2chr5:138456724chr5:139267096ENST00000394770011112_405233.33333333333334491.0Topological domainExtracellular


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Fusion Gene Sequence for SIL1-NRG2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000265195_ENST00000394770_TCGA-BH-A0H9-01A_SIL1_chr5_138456724_-_NRG2_chr5_139267096_length(transcript)=2544nt_BP=390nt
CTGGAATTGTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGCCAGCTATTACTTCTCTACTGAGGCCAACTGTGAGCCCTGG
TGTGTTTCATTGGCAGGAGAAGAGGCTAATTAAGTGAAACTGAAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGG
CTCCTCTGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCA
ACCCAGAGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACC
CGACGCATGAGTGGCAGGCCCTTCAGCCAGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAAT
CGCTGAAGTGTGAGGCAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTC
GCATCAAATATGGCAACGGCAGAAAGAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCG
AGAACATCCTGGGGAAGGACACCGTCCGGGGCCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGA
AGTGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAA
ATGGATTCTTCGGACAGAGATGTTTGGAGAAACTGCCTTTGCGATTGTACATGCCAGATCCTAAGCAAAGTGTCCTGTGGGATACACCGG
GGACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGT
GGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAA
CATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATAT
TTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCA
CTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCA
GTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAA
CCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTC
GGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAA
CTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCC
CGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCC
CGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGA
GACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCG
CCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGC
CTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGC
GCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAG
ACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGCCCCACT
ATCTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAAAAAGTA
TAACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATATG

>In-frame_ENST00000265195_ENST00000394770_TCGA-BH-A0H9-01A_SIL1_chr5_138456724_-_NRG2_chr5_139267096_length(amino acids)=459AA_start in transcript=922_stop in transcript=2301
MVNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPAT
DHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRA
TAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPG
PGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGL
AAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPP

--------------------------------------------------------------
>In-frame_ENST00000509534_ENST00000394770_TCGA-BH-A0H9-01A_SIL1_chr5_138456724_-_NRG2_chr5_139267096_length(transcript)=2632nt_BP=478nt
ATTACTTCTCTACTGAGGCCAACTGTGAGCCCTGGTGTGTTTCATTGGCAGGAGAAGAGGCTAATTAAGTGAAACTGAAAGAACAAATAA
AATGATGAGTCCAGTTTCTGTGGCTGATTTCACAGACCCCTCGAGAGACAGCACGGCTATGGAAAGAGCATGGCTTTGGGGCCAAACTGG
CTTTGAATTCTGACTCTACTGCTCTGTGGCTGCATGAACTCTGGCACGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATG
GCTCCTCTGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGGAGTTTGCCCTGACCAAC
CCAGAGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCG
ACGCATGAGTGGCAGGCCCTTCAGCCAGCCACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCG
CTGAAGTGTGAGGCAGCAGCCGGTAATCCCCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGC
ATCAAATATGGCAACGGCAGAAAGAACTCACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAG
AACATCCTGGGGAAGGACACCGTCCGGGGCCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAG
TGCAACGAGACAGCCAAGTCCTATTGCGTCAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAAT
GGATTCTTCGGACAGAGATGTTTGGAGAAACTGCCTTTGCGATTGTACATGCCAGATCCTAAGCAAAGTGTCCTGTGGGATACACCGGGG
ACAGGTGTCAGCAGTTCGCAATGGTCAACTTCTCCAAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGTGG
CTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAACA
TGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATATTT
CCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCACT
GCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCAGT
CGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAACC
TGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTCGG
CCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAACT
CGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCCCG
GCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCCCG
GACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGAGA
CCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCGCC
GCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGCCT
CGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGCGC
TGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAGAC
ACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGCCCCACTAT
CTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAAAAAGTATA
ACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATATGTA

>In-frame_ENST00000509534_ENST00000394770_TCGA-BH-A0H9-01A_SIL1_chr5_138456724_-_NRG2_chr5_139267096_length(amino acids)=459AA_start in transcript=1010_stop in transcript=2389
MVNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPAT
DHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRA
TAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPG
PGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGL
AAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPP

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000541337_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3962nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGG
CATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAACATGTGCCCGGCCCATCA
GAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATATTTCCAAGAACGTGCCAGC
CACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCACTGCTCCACAGCCACACC
CACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCAGTCGGGGATCATGCTATC
ATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAACCTGGAGGAGCGGCGCAG
GGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTCGGCCCTGACCACGCCCGC
GCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAACTCGGCGCACGCCGTGTC
GCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCCCGGCCCGGGACCCGGACC
CGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCCCGGACCGCGGCGCGGGAC
CTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGAGACCACGCAGGAGTGCGC
GCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCGCCGCTCGCGCCTCAACGG
GCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGCCTCGGCGTCGGACGACGA
CGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGCGCTGCGCTCGGACTCGCC
GCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAGACACAGCCGCGGGCCGCC
CCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGCCCCACTATCTTTAAGGAGACCAGA
GACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAAAAAGTATAACAAAATGTTTTATTT
TCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATATGTAACATCCTGATTTACAG
CTTCGGAAAAAAAAAAGAAACAACAAAAAAAAAAGAGAGATGGGCCAATTTTTTGACTCTTTAATAGAAACCTATTTTGTGGTGCCTTTT
GCTGTATGCTCATCTGGGGCTCCGGGGGACAGGTCTGGGTTGTGGGGTGCTGAGAGTGACAGCTGGGAGAGAAGAGGTGCGGGTTCTGTT
GGGGGCGAGGGTGGGGGGCGGTGGGGGGTTGGCCCTAAGGAAGAACTGAGGACGGAAGTAGCTTTGCTCCCAGGCAAGAGCTGAAGTTCC
CGACCCCTGGGAGGAGAGGGCCAGGACCCTAGGCTTGGAGCTGGAGCTGGGGTAACTTCCAGGGGGAGATAAAGACACAGCTACCCGAAT
GGGGAAGCCCTGGCTACTCACAGCTGTTAAAGGAGGGGGGGCAGAGAAACGTTTCCCCAAGAGCCTGAGCCCAGGGAGGTGGCAGCTCTG
CCAGGGGCCCAATGTTGGCGGCTCCTGTCCCCCACAGCCTCCAGGACGCCCCTCCGTCCTCTGCAGCACCTTCGTTTACAGGTCGTCTTT
TCTATTTTACACCTGCATGTCCTTTGCATTTCAGATTCTTTAGATTGGATGCATGGTCACGCTGGGACCGAGAAGAGCCACTCGACAGTG
TATTCCCCTTTTAGCAATAAAGTAACACCATTTCCTTCTCACAGGCTGCCTCCTAGCCCCCAACCCACCTATGACATCCACTCGTCTCCA
GTCCTGCCCTCCCACCCCCAAAAACTGGGTCCACTGCTAATTTGTCAAAAAGGTAATTGTTTAAAAAAAAAAAAAATCCCAAACAGAAAC
AGATGGGAATCCTGTCCTGAAATGTCTGAACACCTGACTGTTGACACTTGAACATTTTTATATTATAAATAAAATCAGAAATAACTCCTG

>In-frame_ENST00000394817_ENST00000541337_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=546AA_start in transcript=1183_stop in transcript=2823
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHV
IRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAP
PYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGP
GPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQ
RARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAK

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000289422_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3314nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAATGGATTCTTCGGACAGAGATGTTTGGAGAA
ACTGCCTTTGCGATTGTACATGCCAGATCCTAAGCAAAAGCACCTTGGATTTGAATTAAAGGAAGCCGAGGAGCTGTACCAGAAGAGGGT
CCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCA
GATGCACAACCACCTCCGGCAGAACATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGA
GGAGATCCAGATGGCAGATTATATTTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAG
CCACTCCTGTTCTCCTTCTCACCACTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTC
TGAGAGCCTGACTTCTGACTCCCAGTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCG
GGCAAGGCGGGCAGCAGCCTACAACCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTC
CCCACACAGCGAGAGGTACGTGTCGGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCC
AACTTTCGAGATCACGTCCCCCAACTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCC
GTTACTGCGGCACCCGGCGCCCCCCGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAG
CTACTATTACCCCGCGGCGGGGCCCGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCG
CATCCCCGAGGACGACGAGTACGAGACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGAC
GTCGGCGGGGCCCCGGCGCTGGCGCCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAG
CAGCGGCTCGGGCGGCGGCTCAGCCTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCT
GGGCCTGCGTGGGGCGCACGACGCGCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAG
CCACAGCACGCGGGCCAGCAGCAGACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCG
CCCCTCCGCCCCGCCCGCCCCACTATCTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTT
ATTTTCTATAAAAGGAAAAAAGTATAACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGT

>In-frame_ENST00000394817_ENST00000289422_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=620AA_start in transcript=1183_stop in transcript=3045
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTIT
GICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCS
PSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSE
RYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYP
AAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSG

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000361474_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3264nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAATGGATTCTTCGGACAGAGATGTTTGGAGAA
ACTGCCTTTGCGATTGTACATGCCAGATCCTAAGCAAAAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGT
GGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAA
CATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATAT
TTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCA
CTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCA
GTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAA
CCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTC
GGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAA
CTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCC
CGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCC
CGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGA
GACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCG
CCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGC
CTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGC
GCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAG
ACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGCCCCACT
ATCTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAAAAAGTA
TAACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATTTATATG

>In-frame_ENST00000394817_ENST00000361474_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=612AA_start in transcript=1183_stop in transcript=3021
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLV
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTA
TPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRR
GTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000545385_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3270nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAGTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTT
CGCAATGGTCAACTTCTCCACAAGACTAGGGGGAGATGTAGAGGAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCAT
CTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCG
GCAGAACATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGA
TTATATTTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTC
TCACCACTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGA
CTCCCAGTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGC
CTACAACCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTA
CGTGTCGGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTC
CCCCAACTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGC
GCCCCCCGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGC
GGGGCCCGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGA
GTACGAGACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCG
CTGGCGCCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGG
CTCAGCCTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCA
CGACGCGCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAG
CAGCAGACACAGCCGCGGGCCGCCCCCGCGGGCCAAGCAGGACTCGGCGCCACTCTAGGGCCCCGCCGCGCGCCCCTCCGCCCCGCCCGC
CCCACTATCTTTAAGGAGACCAGAGACCGCCTACTGGAGAGAAAGGAGGAAAAAAGAAATAAAAATATTTTTATTTTCTATAAAAGGAAA
AAAGTATAACAAAATGTTTTATTTTCATTTTAGCAAAAATTGTCTTATAATACTAGCTAACGGCAAAGGCGTTTTTATAGGGAAACTATT

>In-frame_ENST00000394817_ENST00000545385_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=614AA_start in transcript=1183_stop in transcript=3027
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSTRLGGDVEEAEELYQKRVLTITGICVAL
LVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCS
TATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSAL
TTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGP
RRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASA

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000358522_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3028nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAGTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTT
CGCAATGGTCAACTTCTCCAAGCACCTTGGATTTGAATTAAAGGAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCAT
CTGCGTGGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCG
GCAGAACATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGA
TTATATTTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTC
TCACCACTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGA
CTCCCAGTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGC
CTACAACCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTA
CGTGTCGGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTC
CCCCAACTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGC
GCCCCCCGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGC
GGGGCCCGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGA
GTACGAGACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCG
CTGGCGCCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGG
CTCAGCCTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCA
CGACGCGCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAG

>In-frame_ENST00000394817_ENST00000358522_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=615AA_start in transcript=1183_stop in transcript=3027
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVAL
LVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCS
TATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSAL
TTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGP
RRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASA

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000289409_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3004nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAGTGTCCTGTGGGATACACCGGGGACAGGTGTCAGCAGTT
CGCAATGGTCAACTTCTCCAAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGTGGCTCTGCTGGTCGTGGG
CATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAACATGTGCCCGGCCCATCA
GAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATATTTCCAAGAACGTGCCAGC
CACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCACTGCTCCACAGCCACACC
CACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCAGTCGGGGATCATGCTATC
ATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAACCTGGAGGAGCGGCGCAG
GGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTCGGCCCTGACCACGCCCGC
GCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAACTCGGCGCACGCCGTGTC
GCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCCCGGCCCGGGACCCGGACC
CGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCCCGGACCGCGGCGCGGGAC
CTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGAGACCACGCAGGAGTGCGC
GCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCGCCGCTCGCGCCTCAACGG
GCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGCCTCGGCGTCGGACGACGA
CGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGCGCTGCGCTCGGACTCGCC
GCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAGACACAGCCGCGGGCCGCC

>In-frame_ENST00000394817_ENST00000289409_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=607AA_start in transcript=1183_stop in transcript=3003
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICVALLVVGIVCV
VAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSH
RHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSP
VDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALG
GSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDA

--------------------------------------------------------------
>In-frame_ENST00000394817_ENST00000340391_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(transcript)=3022nt_BP=1169nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGGCAGGCTGTCCCTGCAGGATCCCACGTACGGCTGAATCTTCAGACTGGGGAAAGAGAGGCAAAAC
TCCAATATGAGGACAAGTTCCGAAATAATTTGAAAGGCAAAAGGCTGGATATCAACACCAACACCTACACATCTCAGGATCTCAAGAGTG
CACTGGCAAAATTCAAGGAGGGGGCAGAGATGGAGAGTTCAAAGGAAGACAAGGCAAGGCAGGCTGAGGTAAAGCGGCTCTTCCGCCCCA
TTGAGGAACTGAAGAAAGACTTTGATGAGCTGAATGTTGTCATTGAGACTGACATGCAGATCATGGTACGGCTGATCAACAAGTTCAATA
GTTCCAGCTCCAGTTTGGAAGAGAAGATTGCTGCGCTCTTTGATCTTGAATATTATGTCCATCAGATGGACAATGCGCAGGACCTGCTTT
CCTTTGGTGGTCTTCAAGTGGTGATCAATGGGCTGAACAGCACAGAGCCCCTCGTGAAGGAGTATGCTGCGTTTGTGCTGGGCGCTGCCT
TTTCCAGCAACCCCAAGGTCCAGGTGGAGGCCATCGAAGGGGGAGCCCTGCAGAAGCTGCTGGTCATCCTGGCCACGGAGCAGCCGCTCA
CTGCAAAGAAGAAGGTCCTGTTTGCACTGTGCTCCCTGCTGCGCCACTTCCCCTATGCCCAGCGGCAGTTCCTGAAGCTCGGGGGGCTGC
AGGTCCTGAGGACCCTGGTGCAGGAGAAGGGCACGGAGGTGCTCGCCGTGCGCGTGGTCACACTGCTCTACGACCTGGTCACGGAGAAGC
CACCCGGCCCAAGTTGAAGAAGATGAAGAGCCAGACGGGACAGGTGGGTGAGAAGCAATCGCTGAAGTGTGAGGCAGCAGCCGGTAATCC
CCAGCCTTCCTACCGTTGGTTCAAGGATGGCAAGGAGCTCAACCGCAGCCGAGACATTCGCATCAAATATGGCAACGGCAGAAAGAACTC
ACGACTACAGTTCAACAAGGTGAAGGTGGAGGACGCTGGGGAGTATGTCTGCGAGGCCGAGAACATCCTGGGGAAGGACACCGTCCGGGG
CCGGCTTTACGTCAACAGCGTGAGCACCACCCTGTCATCCTGGTCGGGGCACGCCCGGAAGTGCAACGAGACAGCCAAGTCCTATTGCGT
CAATGGAGGCGTCTGCTACTACATCGAGGGCATCAACCAGCTCTCCTGCAAATGTCCAAATGGATTCTTCGGACAGAGATGTTTGGAGAA
ACTGCCTTTGCGATTGTACATGCCAGATCCTAAGCAAAAAGCCGAGGAGCTGTACCAGAAGAGGGTCCTGACCATCACGGGCATCTGCGT
GGCTCTGCTGGTCGTGGGCATCGTCTGTGTGGTGGCCTACTGCAAGACCAAAAAACAGCGGAAGCAGATGCACAACCACCTCCGGCAGAA
CATGTGCCCGGCCCATCAGAACCGGAGCTTGGCCAATGGGCCCAGCCACCCCCGGCTGGACCCAGAGGAGATCCAGATGGCAGATTATAT
TTCCAAGAACGTGCCAGCCACAGACCATGTCATCAGGAGAGAAACTGAGACCACCTTCTCTGGGAGCCACTCCTGTTCTCCTTCTCACCA
CTGCTCCACAGCCACACCCACCTCCAGCCACAGACACGAGAGCCACACGTGGAGCCTGGAACGTTCTGAGAGCCTGACTTCTGACTCCCA
GTCGGGGATCATGCTATCATCAGTGGGTACCAGCAAATGCAACAGCCCAGCATGTGTGGAGGCCCGGGCAAGGCGGGCAGCAGCCTACAA
CCTGGAGGAGCGGCGCAGGGCCACCGCGCCACCCTATCACGATTCCGTGGACTCCCTTCGCGACTCCCCACACAGCGAGAGGTACGTGTC
GGCCCTGACCACGCCCGCGCGCCTCTCGCCCGTGGACTTCCACTACTCGCTGGCCACGCAGGTGCCAACTTTCGAGATCACGTCCCCCAA
CTCGGCGCACGCCGTGTCGCTGCCGCCGGCGGCGCCCATCAGTTACCGCCTGGCCGAGCAGCAGCCGTTACTGCGGCACCCGGCGCCCCC
CGGCCCGGGACCCGGACCCGGGCCCGGGCCCGGGCCCGGCGCAGACATGCAGCGCAGCTATGACAGCTACTATTACCCCGCGGCGGGGCC
CGGACCGCGGCGCGGGACCTGCGCGCTCGGCGGCAGCCTGGGCAGCCTGCCTGCCAGCCCCTTCCGCATCCCCGAGGACGACGAGTACGA
GACCACGCAGGAGTGCGCGCCCCCGCCGCCGCCGCGGCCGCGCGCGCGCGGTGCGTCCCGCAGGACGTCGGCGGGGCCCCGGCGCTGGCG
CCGCTCGCGCCTCAACGGGCTGGCGGCGCAGCGCGCACGGGCGGCGAGGGACTCGCTGTCGCTGAGCAGCGGCTCGGGCGGCGGCTCAGC
CTCGGCGTCGGACGACGACGCGGACGACGCGGACGGGGCGCTGGCGGCCGAGAGCACACCTTTCCTGGGCCTGCGTGGGGCGCACGACGC
GCTGCGCTCGGACTCGCCGCCACTGTGCCCGGCGGCCGACAGCAGGACTTACTACTCACTGGACAGCCACAGCACGCGGGCCAGCAGCAG

>In-frame_ENST00000394817_ENST00000340391_TCGA-EP-A2KA-01A_SIL1_chr5_138286860_-_NRG2_chr5_139267096_length(amino acids)=613AA_start in transcript=1183_stop in transcript=3021
MKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYV
NSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLV
VGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTA
TPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTT
PARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRR
GTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIL1-NRG2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSIL1chr5:138286860chr5:139267096ENST00000265195-10111_256343.0462.0HSPA5 and localization to the endoplasmic reticulum
HgeneSIL1chr5:138286860chr5:139267096ENST00000394817-9101_256343.0462.0HSPA5 and localization to the endoplasmic reticulum


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSIL1chr5:138456724chr5:139267096ENST00000265195-4111_25681.33333333333333462.0HSPA5 and localization to the endoplasmic reticulum
HgeneSIL1chr5:138456724chr5:139267096ENST00000394817-3101_25681.33333333333333462.0HSPA5 and localization to the endoplasmic reticulum


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIL1-NRG2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIL1-NRG2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSIL1C0024814Marinesco-Sjogren syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneSIL1C0033578Prostatic Neoplasms1CTD_human
HgeneSIL1C0376358Malignant neoplasm of prostate1CTD_human
HgeneSIL1C3495676Anorectal Malformations1GENOMICS_ENGLAND