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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:SIRPB2-HSPA1A (FusionGDB2 ID:81412) |
Fusion Gene Summary for SIRPB2-HSPA1A |
Fusion gene summary |
Fusion gene information | Fusion gene name: SIRPB2-HSPA1A | Fusion gene ID: 81412 | Hgene | Tgene | Gene symbol | SIRPB2 | HSPA1A | Gene ID | 284759 | 3303 |
Gene name | signal regulatory protein beta 2 | heat shock protein family A (Hsp70) member 1A | |
Synonyms | PTPN1L|PTPNS1L3|dJ776F14.2 | HEL-S-103|HSP70-1|HSP70-1A|HSP70-2|HSP70.1|HSP70.2|HSP70I|HSP72|HSPA1 | |
Cytomap | 20p13 | 6p21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | signal-regulatory protein beta-2SIRP-beta-2protein tyrosine phosphatase non-receptor type substrate proteinprotein tyrosine phosphatase, non-receptor type substrate 1-like 3 | heat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103epididymis secretory sperm binding proteinheat shock 70 kDa pr | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | P0DMV8 | |
Ensembl transtripts involved in fusion gene | ENST00000359801, ENST00000444444, ENST00000537284, ENST00000608747, | ENST00000375651, ENST00000458062, ENST00000608703, ENST00000430065, ENST00000422919, ENST00000441618, ENST00000449876, ENST00000433487, ENST00000452298, ENST00000400040, ENST00000383389, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 15 X 4=360 |
# samples | 1 | 11 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SIRPB2 [Title/Abstract] AND HSPA1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | SIRPB2(1470878)-HSPA1A(31784817), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | HSPA1A | GO:0006402 | mRNA catabolic process | 10205060 |
Tgene | HSPA1A | GO:0006986 | response to unfolded protein | 10859165 |
Tgene | HSPA1A | GO:0031396 | regulation of protein ubiquitination | 16809764 |
Tgene | HSPA1A | GO:0031397 | negative regulation of protein ubiquitination | 12150907 |
Tgene | HSPA1A | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 24613385 |
Tgene | HSPA1A | GO:0033120 | positive regulation of RNA splicing | 20625543 |
Tgene | HSPA1A | GO:0034605 | cellular response to heat | 24061851 |
Tgene | HSPA1A | GO:0042026 | protein refolding | 15603737|21231916 |
Tgene | HSPA1A | GO:0046034 | ATP metabolic process | 23921388 |
Tgene | HSPA1A | GO:0050821 | protein stabilization | 21909508 |
Tgene | HSPA1A | GO:0051131 | chaperone-mediated protein complex assembly | 10811660 |
Tgene | HSPA1A | GO:0090084 | negative regulation of inclusion body assembly | 15603737|21231916 |
Tgene | HSPA1A | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress | 9499401 |
Tgene | HSPA1A | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 20625543 |
Tgene | HSPA1A | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 12150907|20625543 |
Tgene | HSPA1A | GO:1902380 | positive regulation of endoribonuclease activity | 20625543 |
Fusion gene breakpoints across SIRPB2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across HSPA1A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | AK097113 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
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Fusion Gene ORF analysis for SIRPB2-HSPA1A |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000359801 | ENST00000375651 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000359801 | ENST00000458062 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000359801 | ENST00000608703 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000430065 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000422919 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000441618 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000449876 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000433487 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000452298 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000400040 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000359801 | ENST00000383389 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000444444 | ENST00000375651 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000444444 | ENST00000458062 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000444444 | ENST00000608703 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000430065 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000422919 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000441618 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000449876 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000433487 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000452298 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000400040 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000444444 | ENST00000383389 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000537284 | ENST00000375651 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000537284 | ENST00000458062 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000537284 | ENST00000608703 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000430065 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000422919 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000441618 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000449876 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000433487 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000452298 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000400040 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000537284 | ENST00000383389 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000608747 | ENST00000375651 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000608747 | ENST00000458062 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-3CDS | ENST00000608747 | ENST00000608703 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000430065 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000422919 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000441618 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000449876 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000433487 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000452298 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000400040 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
intron-intron | ENST00000608747 | ENST00000383389 | SIRPB2 | chr20 | 1470878 | - | HSPA1A | chr6 | 31784817 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for SIRPB2-HSPA1A |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SIRPB2-HSPA1A |
Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | HSPA1A |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for SIRPB2-HSPA1A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for SIRPB2-HSPA1A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SIRPB2-HSPA1A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SIRPB2-HSPA1A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HSPA1A | C0036341 | Schizophrenia | 5 | PSYGENET |
Tgene | HSPA1A | C0041696 | Unipolar Depression | 3 | PSYGENET |
Tgene | HSPA1A | C1269683 | Major Depressive Disorder | 3 | PSYGENET |
Tgene | HSPA1A | C0022660 | Kidney Failure, Acute | 2 | CTD_human |
Tgene | HSPA1A | C1565662 | Acute Kidney Insufficiency | 2 | CTD_human |
Tgene | HSPA1A | C2609414 | Acute kidney injury | 2 | CTD_human |
Tgene | HSPA1A | C0013182 | Drug Allergy | 1 | CTD_human |
Tgene | HSPA1A | C0023895 | Liver diseases | 1 | CTD_human |
Tgene | HSPA1A | C0024517 | Major depression, single episode | 1 | PSYGENET |
Tgene | HSPA1A | C0025202 | melanoma | 1 | CTD_human |
Tgene | HSPA1A | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | HSPA1A | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | HSPA1A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | HSPA1A | C0035126 | Reperfusion Injury | 1 | CTD_human |
Tgene | HSPA1A | C0036349 | Paranoid Schizophrenia | 1 | PSYGENET |
Tgene | HSPA1A | C0086565 | Liver Dysfunction | 1 | CTD_human |
Tgene | HSPA1A | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | HSPA1A | C0282507 | Heat Stress Disorders | 1 | CTD_human |
Tgene | HSPA1A | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | HSPA1A | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |