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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SLA-GSDMB (FusionGDB2 ID:81589) |
Fusion Gene Summary for SLA-GSDMB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLA-GSDMB | Fusion gene ID: 81589 | Hgene | Tgene | Gene symbol | SLA | GSDMB | Gene ID | 51091 | 55876 |
| Gene name | Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase | gasdermin B | |
| Synonyms | LP|PCH2D|SLA|SLA/LP | GSDMB-1|GSDML|PP4052|PRO2521 | |
| Cytomap | 4p15.2 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | O-phosphoseryl-tRNA(Sec) selenium transferaseSLA-p35SLA/LP autoantigenUGA suppressor tRNA-associated proteinliver-pancreas antigensoluble liver antigensoluble liver antigen/liver pancreas antigentRNA(Ser/Sec)-associated antigenic protein | gasdermin-Bgasdermin-like proteingasderminB-1 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q8TAX9 | |
| Ensembl transtripts involved in fusion gene | ENST00000338087, ENST00000395352, ENST00000524345, ENST00000517648, ENST00000518565, ENST00000427060, | ENST00000360317, ENST00000394175, ENST00000309481, ENST00000520542, ENST00000418519, ENST00000394179, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 12 X 13 X 9=1404 |
| # samples | 4 | 15 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/1404*10)=-3.22650852980868 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLA [Title/Abstract] AND GSDMB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SLA(134060075)-GSDMB(38063240), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across SLA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GSDMB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | KIRC | TCGA-BP-4169-01A | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
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Fusion Gene ORF analysis for SLA-GSDMB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000338087 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000338087 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000338087 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000338087 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000338087 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000338087 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| In-frame | ENST00000395352 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000395352 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000395352 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000395352 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000395352 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000395352 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| Frame-shift | ENST00000524345 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000524345 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000524345 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000524345 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000524345 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000524345 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| In-frame | ENST00000517648 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000517648 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000517648 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000517648 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000517648 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000517648 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-3CDS | ENST00000518565 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-intron | ENST00000518565 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-intron | ENST00000518565 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-intron | ENST00000518565 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-intron | ENST00000518565 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| intron-intron | ENST00000518565 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| In-frame | ENST00000427060 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000427060 | ENST00000394175 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000427060 | ENST00000309481 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000427060 | ENST00000520542 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000427060 | ENST00000418519 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| 5CDS-intron | ENST00000427060 | ENST00000394179 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000395352 | SLA | chr8 | 134060075 | - | ENST00000360317 | GSDMB | chr17 | 38063240 | - | 1520 | 752 | 346 | 1302 | 318 |
| ENST00000517648 | SLA | chr8 | 134060075 | - | ENST00000360317 | GSDMB | chr17 | 38063240 | - | 1220 | 452 | 46 | 1002 | 318 |
| ENST00000427060 | SLA | chr8 | 134060075 | - | ENST00000360317 | GSDMB | chr17 | 38063240 | - | 1318 | 550 | 78 | 1100 | 340 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000395352 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - | 0.002632042 | 0.99736804 |
| ENST00000517648 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - | 0.00320073 | 0.99679923 |
| ENST00000427060 | ENST00000360317 | SLA | chr8 | 134060075 | - | GSDMB | chr17 | 38063240 | - | 0.001922108 | 0.99807787 |
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Fusion Genomic Features for SLA-GSDMB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SLA-GSDMB |
| Go to FGviewer for the breakpoints of chr8:134060075-chr17:38063240 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | GSDMB |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: [Gasdermin-B]: Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). {ECO:0000269|PubMed:32299851}.; FUNCTION: [Gasdermin-B, N-terminal]: Pore-forming protein produced by cleavage by granzyme A (GZMA), which causes membrane permeabilization and pyroptosis in target cells of cytotoxic T and natural killer (NK) cells (PubMed:27281216, PubMed:32299851). Key downstream mediator of granzyme-mediated cell death: (1) granzyme A (GZMA), delivered to target cells from cytotoxic T- and NK-cells, (2) specifically cleaves Gasdermin-B to generate this form (PubMed:32299851). After cleavage, moves to the plasma membrane, homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32299851). Binds to membrane inner leaflet lipids, such as phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, and more weakly to phosphatidic acid (PubMed:28154144). Also binds sufatide, a component of the apical membrane of epithelial cells (PubMed:28154144). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:28154144, ECO:0000269|PubMed:32299851}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLA | chr8:134060075 | chr17:38063240 | ENST00000338087 | - | 6 | 9 | 22_82 | 117.33333333333333 | 277.0 | Domain | SH3 |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000309481 | 4 | 10 | 243_271 | 220.33333333333334 | 404.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000360317 | 4 | 10 | 243_271 | 233.33333333333334 | 417.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000394175 | 0 | 8 | 243_271 | 0 | 395.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000394179 | 0 | 10 | 243_271 | 0 | 412.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000418519 | 5 | 11 | 243_271 | 233.33333333333334 | 417.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000520542 | 0 | 10 | 243_271 | 0 | 408.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000394175 | 0 | 8 | 1_275 | 0 | 395.0 | Region | Triggers pyroptosis | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000394179 | 0 | 10 | 1_275 | 0 | 412.0 | Region | Triggers pyroptosis | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000520542 | 0 | 10 | 1_275 | 0 | 408.0 | Region | Triggers pyroptosis |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLA | chr8:134060075 | chr17:38063240 | ENST00000338087 | - | 6 | 9 | 84_175 | 117.33333333333333 | 277.0 | Domain | SH2 |
| Hgene | SLA | chr8:134060075 | chr17:38063240 | ENST00000338087 | - | 6 | 9 | 212_276 | 117.33333333333333 | 277.0 | Region | Note=SLA C-terminal |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000309481 | 4 | 10 | 1_275 | 220.33333333333334 | 404.0 | Region | Triggers pyroptosis | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000360317 | 4 | 10 | 1_275 | 233.33333333333334 | 417.0 | Region | Triggers pyroptosis | |
| Tgene | GSDMB | chr8:134060075 | chr17:38063240 | ENST00000418519 | 5 | 11 | 1_275 | 233.33333333333334 | 417.0 | Region | Triggers pyroptosis |
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Fusion Gene Sequence for SLA-GSDMB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000395352_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(transcript)=1520nt_BP=752nt ACTGCTACCCACAGGGCCCCCACTCCACCTGCTCCCAGACGAGGCCAACTCCTGGCCAAGCTTAGGGGCACAGCGGAGGCGCTCTGTTTC TGATTTTTCTCGCCTTCCTTGGAGATGCCTGTGCTTGGAAGGGAAGGCAGAACATTGCATCTTGGAACAAATCTGCTTTTGATCATGCAA ATGAATGCCTGGATAATGTAGGCAGACTGTCAATTTCACCAGTTAGAAAGAAAGAGAAAAGGGGGAGAAATTCCCCATGACAGCGACTGA TGAAGAATTTCAATAGAAAGCTGCTACTTCAGAAAATAAGATCATTTGCTGCGAATGGAGAACATCTCAGGCAGCCCTGATGCTCCACCG GCTCTGGGCATCACCAGCGGCCCCAGGGAAAAAGAAAGAAATGGGAAACAGCATGAAATCCACCCCTGCGCCTGCCGAGAGGCCCCTGCC CAACCCGGAGGGACTGGATAGCGACTTCCTTGCCGTGCTAAGTGACTACCCGTCTCCTGACATCAGCCCCCCGATATTCCGCCGAGGGGA GAAACTGCGTGTGATTTCTGATGAAGGGGGCTGGTGGAAAGCTATTTCTCTTAGCACTGGTCGAGAGAGTTACATCCCTGGAATATGTGT GGCCAGAGTTTACCATGGCTGGCTGTTTGAGGGCCTGGGCAGAGACAAGGCCGAGGAGCTGCTGCAGCTGCCAGACACAAAGGTCGGCTC CTTCATGATCAGAGAGAGTGAGACCAAGAAAGAGAAGGATGGTGCTTCATCCTGTTTAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAA CATGAAGGAGAAGTTGGAGGACATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTG CCTCGGCAAGGAGGATATTCGGCAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAA GCCTCTCCTAAGCAGCCTTTTTAATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGA GCTGTCTGAAGAGCAGCAGTTTGTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCA GAACTGGGATGAGCTGGCCAGCAGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTAT CCTGCTGGAGCTGGCTGAGGGGCCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTTTACC AGTCTGTCCTCACTGCCATCGCCACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATCCCAT >In-frame_ENST00000395352_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(amino acids)=318AA_start in transcript=346_stop in transcript=1302 MMLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYI PGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLN SLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVK -------------------------------------------------------------- >In-frame_ENST00000517648_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(transcript)=1220nt_BP=452nt AGAAAATAAGATCATTTGCTGCGAATGGAGAACATCTCAGGCAGCCCTGATGCTCCACCGGCTCTGGGCATCACCAGCGGCCCCAGGGAA AAAGAAAGAAATGGGAAACAGCATGAAATCCACCCCTGCGCCTGCCGAGAGGCCCCTGCCCAACCCGGAGGGACTGGATAGCGACTTCCT TGCCGTGCTAAGTGACTACCCGTCTCCTGACATCAGCCCCCCGATATTCCGCCGAGGGGAGAAACTGCGTGTGATTTCTGATGAAGGGGG CTGGTGGAAAGCTATTTCTCTTAGCACTGGTCGAGAGAGTTACATCCCTGGAATATGTGTGGCCAGAGTTTACCATGGCTGGCTGTTTGA GGGCCTGGGCAGAGACAAGGCCGAGGAGCTGCTGCAGCTGCCAGACACAAAGGTCGGCTCCTTCATGATCAGAGAGAGTGAGACCAAGAA AGAGAAGGATGGTGCTTCATCCTGTTTAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGACATGGAGAG TGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGGCAGGATCT AGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTTAATGCTGC TGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTTGTGGCTGA GGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGCAGTCCTCC TGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGGCCTACCTC TGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGCCACTACCA TCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAAACCAGCCT >In-frame_ENST00000517648_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(amino acids)=318AA_start in transcript=46_stop in transcript=1002 MMLHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYI PGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKEKDGASSCLGKSLGSEDSRNMKEKLEDMESVLKDLTEEKRKDVLN SLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSEEQQFVAEALEKGTLPLLKDQVK -------------------------------------------------------------- >In-frame_ENST00000427060_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(transcript)=1318nt_BP=550nt AACCAATCTTCACCAATCTCATCTTCACATATAAACAGCCGCCTTTCAAGAAGCAAGCTGCCAGAAAAATGATGCACGATGCTCTCTAAA CTGGGTCATTCTCCACTTGGAGGGCTCAGGGCACGGTTGACTTTCCCCGTCTGTCTCCTATACCACAGGCTCTGGGCATCACCAGCGGCC CCAGGGAAAAAGAAAGAAATGGGAAACAGCATGAAATCCACCCCTGCGCCTGCCGAGAGGCCCCTGCCCAACCCGGAGGGACTGGATAGC GACTTCCTTGCCGTGCTAAGTGACTACCCGTCTCCTGACATCAGCCCCCCGATATTCCGCCGAGGGGAGAAACTGCGTGTGATTTCTGAT GAAGGGGGCTGGTGGAAAGCTATTTCTCTTAGCACTGGTCGAGAGAGTTACATCCCTGGAATATGTGTGGCCAGAGTTTACCATGGCTGG CTGTTTGAGGGCCTGGGCAGAGACAAGGCCGAGGAGCTGCTGCAGCTGCCAGACACAAAGGTCGGCTCCTTCATGATCAGAGAGAGTGAG ACCAAGAAAGAGAAGGATGGTGCTTCATCCTGTTTAGGAAAGTCTTTGGGTTCGGAGGATTCCAGAAACATGAAGGAGAAGTTGGAGGAC ATGGAGAGTGTCCTCAAGGACCTGACAGAGGAGAAGAGAAAAGATGTGCTAAACTCCCTCGCTAAGTGCCTCGGCAAGGAGGATATTCGG CAGGATCTAGAGCAAAGAGTATCTGAGGTCCTGATTTCCGGGGAGCTACACATGGAGGACCCAGACAAGCCTCTCCTAAGCAGCCTTTTT AATGCTGCTGGGGTCTTGGTAGAAGCGCGTGCAAAAGCCATTCTGGACTTCCTGGATGCCCTGCTAGAGCTGTCTGAAGAGCAGCAGTTT GTGGCTGAGGCCCTGGAGAAGGGGACCCTTCCTCTGTTGAAGGACCAGGTGAAATCTGTCATGGAGCAGAACTGGGATGAGCTGGCCAGC AGTCCTCCTGACATGGACTATGACCCTGAGGCACGAATTCTCTGTGCGCTGTATGTTGTTGTCTCTATCCTGCTGGAGCTGGCTGAGGGG CCTACCTCTGTCTCTTCCTAACTACAAAAGCCCTTTCTCCCCACAAGCCTCTGGGTTTTCCCTTTACCAGTCTGTCCTCACTGCCATCGC CACTACCATCCTGTCACCAGTGGGACCTCTTTAAAACAAGCAGCCAACCATTCTTTGATGTATCCCATTCGCTCCATGTTAACATCCAAA >In-frame_ENST00000427060_ENST00000360317_TCGA-BP-4169-01A_SLA_chr8_134060075_-_GSDMB_chr17_38063240_length(amino acids)=340AA_start in transcript=78_stop in transcript=1100 MLSKLGHSPLGGLRARLTFPVCLLYHRLWASPAAPGKKKEMGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLR VISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKEKDGASSCLGKSLGSEDSRNMKE KLEDMESVLKDLTEEKRKDVLNSLAKCLGKEDIRQDLEQRVSEVLISGELHMEDPDKPLLSSLFNAAGVLVEARAKAILDFLDALLELSE -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SLA-GSDMB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SLA-GSDMB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SLA-GSDMB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLA | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | SLA | C0042900 | Vitiligo | 1 | CTD_human |
| Tgene | GSDMB | C0004096 | Asthma | 1 | CTD_human |
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