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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC19A2-KDM4C (FusionGDB2 ID:81799)

Fusion Gene Summary for SLC19A2-KDM4C

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC19A2-KDM4C
Fusion gene ID: 81799
HgeneTgene
Gene symbol

SLC19A2

KDM4C

Gene ID

10560

23081

Gene namesolute carrier family 19 member 2lysine demethylase 4C
SynonymsTC1|THMD1|THT1|THTR1|TRMAGASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap

1q24.2

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionthiamine transporter 1high affinity thiamine transporterreduced folate carrier protein (RFC) likesolute carrier family 19 (thiamine transporter), member 2thTr-1lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2020031320200329
UniProtAcc.

Q9H3R0

Ensembl transtripts involved in fusion geneENST00000236137, ENST00000367804, 
ENST00000535193, ENST00000543771, 
ENST00000381306, ENST00000381309, 
ENST00000442236, ENST00000489243, 
ENST00000536108, ENST00000428870, 
ENST00000401787, 
Fusion gene scores* DoF score4 X 4 X 2=3222 X 22 X 7=3388
# samples 426
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(26/3388*10)=-3.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC19A2 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC19A2(169446393)-KDM4C(7046862), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across SLC19A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0E1-01ASLC19A2chr1

169446393

-KDM4Cchr9

7046862

+


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Fusion Gene ORF analysis for SLC19A2-KDM4C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000236137ENST00000535193SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
In-frameENST00000236137ENST00000543771SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
In-frameENST00000236137ENST00000381306SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
In-frameENST00000236137ENST00000381309SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
In-frameENST00000236137ENST00000442236SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
5CDS-intronENST00000236137ENST00000489243SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
5CDS-intronENST00000236137ENST00000536108SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
5CDS-intronENST00000236137ENST00000428870SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
5CDS-intronENST00000236137ENST00000401787SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-3CDSENST00000367804ENST00000535193SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-3CDSENST00000367804ENST00000543771SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-3CDSENST00000367804ENST00000381306SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-3CDSENST00000367804ENST00000381309SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-3CDSENST00000367804ENST00000442236SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-intronENST00000367804ENST00000489243SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-intronENST00000367804ENST00000536108SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-intronENST00000367804ENST00000428870SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+
intron-intronENST00000367804ENST00000401787SLC19A2chr1

169446393

-KDM4Cchr9

7046862

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000236137SLC19A2chr1169446393-ENST00000535193KDM4Cchr97046862+203810441231226367
ENST00000236137SLC19A2chr1169446393-ENST00000543771KDM4Cchr97046862+203810441231226367
ENST00000236137SLC19A2chr1169446393-ENST00000381306KDM4Cchr97046862+282110441231928601
ENST00000236137SLC19A2chr1169446393-ENST00000381309KDM4Cchr97046862+287510441231955610
ENST00000236137SLC19A2chr1169446393-ENST00000442236KDM4Cchr97046862+205110441231955610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000236137ENST00000535193SLC19A2chr1169446393-KDM4Cchr97046862+0.0010510010.998949
ENST00000236137ENST00000543771SLC19A2chr1169446393-KDM4Cchr97046862+0.0010510010.998949
ENST00000236137ENST00000381306SLC19A2chr1169446393-KDM4Cchr97046862+0.000399060.99960095
ENST00000236137ENST00000381309SLC19A2chr1169446393-KDM4Cchr97046862+0.0006008130.9993992
ENST00000236137ENST00000442236SLC19A2chr1169446393-KDM4Cchr97046862+0.0013280570.998672

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Fusion Genomic Features for SLC19A2-KDM4C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC19A2chr1169446392-KDM4Cchr97046861+0.0054154050.9945846
SLC19A2chr1169446392-KDM4Cchr97046861+0.0054154050.9945846

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC19A2-KDM4C


check button Go to

FGviewer for the breakpoints of chr1:169446393-chr9:7046862

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KDM4C

Q9H3R0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26119_128269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26150_165269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26186_191269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-261_28269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2647_72269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2692_99269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26100_118269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26129_149269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26166_185269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26192_208269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2629_46269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-2673_91269.0498.0TransmembraneHelical
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421877_934753.01048.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421935_991753.01048.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422877_934753.01057.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422935_991753.01057.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418877_934775.0836.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418935_991775.0836.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418877_934753.0814.0DomainNote=Tudor 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418935_991753.0814.0DomainNote=Tudor 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421752_785753.01048.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421808_865753.01048.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422752_785753.01057.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422808_865753.01057.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418808_865775.0836.0Zinc fingerPHD-type 2
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418752_785753.0814.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418808_865753.0814.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26209_285269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26311_337269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26355_363269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26381_386269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26410_419269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26444_455269.0498.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26480_497269.0498.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15119_1280297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15150_1650297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15186_1910297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-151_280297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15209_2850297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15311_3370297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15355_3630297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15381_3860297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15410_4190297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15444_4550297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1547_720297.0Topological domainExtracellular
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15480_4970297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1592_990297.0Topological domainCytoplasmic
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26286_310269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26338_354269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26364_380269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26387_409269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26420_443269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000236137-26456_479269.0498.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15100_1180297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15129_1490297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15166_1850297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15192_2080297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15286_3100297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1529_460297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15338_3540297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15364_3800297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15387_4090297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15420_4430297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-15456_4790297.0TransmembraneHelical
HgeneSLC19A2chr1:169446393chr9:7046862ENST00000367804-1573_910297.0TransmembraneHelical
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421144_310753.01048.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000381306142116_58753.01048.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422144_310753.01057.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000381309142216_58753.01057.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418144_310775.0836.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000535193141816_58775.0836.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418144_310753.0814.0DomainJmjC
TgeneKDM4Cchr1:169446393chr9:7046862ENST00000543771141816_58753.0814.0DomainJmjN
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813061421689_747753.01048.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000003813091422689_747753.01057.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418689_747775.0836.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005351931418752_785775.0836.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr1:169446393chr9:7046862ENST000005437711418689_747753.0814.0Zinc fingerNote=PHD-type 1


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Fusion Gene Sequence for SLC19A2-KDM4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000236137_ENST00000535193_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(transcript)=2038nt_BP=1044nt
GGCAGAGGGTGGGCCTTAGGACGGGTCTCCCTTAAACTGGGCGATCAGGCAGCGACCCTAGAGGCGTCTGTAGGGTAAAGCTGGGGGTTC
TGTAGCCGGAGGCGGCGGCGAGTCCAGAACGTCCTGGCCTTACAGGGAGAAGGCGTCACTCGCGGTTACAAGTGCCTGACCCTCACTCCA
GTTGGCGGAGGAGGAGAAGGAAGGGGCCGGGCCGGGTCCCCTCCCCTCGCGCCCCGGATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCG
GCGGCGGCGGCGGCCACTGTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTACGGC
TTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTTCCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGGTCTTCAAT
GAAATTTATCCAGTATGGACTTACTCTTACCTGGTGCTACTGTTTCCTGTGTTCCTTGCCACAGACTACCTCCGTTATAAACCTGTTGTT
CTACTGCAGGGGCTCAGCCTTATTGTTACATGGTTTATGCTGCTCTATGCCCAGGGACTGCTGGCCATTCAATTTCTAGAATTTTTTTAT
GGCATCGCCACAGCCACTGAAATTGCCTATTACTCTTATATCTACAGTGTGGTGGACCTGGGCATGTACCAGAAAGTCACAAGTTACTGT
CGAAGTGCCACTTTGGTGGGCTTTACAGTGGGCTCTGTCCTAGGGCAAATCCTTGTCTCAGTGGCAGGCTGGTCGCTGTTCAGCCTGAAT
GTCATCTCTCTTACCTGTGTTTCAGTGGCTTTTGCTGTGGCCTGGTTTTTACCTATGCCACAGAAGAGCCTCTTCTTTCACCACATTCCT
TCTACCTGCCAGAGAGTGAATGGCATCAAGGTACAAAATGGTGGCATTGTTACTGACACCCCAGCTTCTAACCACCTTCCTGGCTGGGAG
GACATTGAGTCAAAAATCCCTCTAAATATGGAGGAGCCTCCCGTGGAGGAACCGGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTT
AAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAA
ATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAGACACAGCAACAGTAACAACAACAACAATAACAA
TGAAGGCTCACTGTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCGCCACTGTTTCAGATGCTGTTTCTCATTCTCCATGGGAG
CAGCCAGCATCGTGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGAGTCAGACCCTGGACTTTCCCTTTTGTATCTGTCATTTT
CCTCTGGATCCTCACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGACTTCCTATGTGGGGTAAAATGACTTCCTTTGATTAATG
TACTTTCTGTATCCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTGTCCTACTACAGCCTCAAAAATTGTCATTGGAATCAAAA
GCTTTCCAAGGTGCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTCCTGTAGCATGGAGGCATTATAATAGGAGTCTCAGAAGT
TACACCATTTTTCTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGAATCCACTCTATGTCTGTCAGCCTGAATCCTTCCTTCTT
GCTGCACAACAAAGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCACTCATTCATCAAAGTTCTATCTGGGTGATATATGCTATC
GAAACAGATGTGGACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTGAAGCTCATGTTATCACACATGCTGTGGGAAGAGAGGTC

>In-frame_ENST00000236137_ENST00000535193_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(amino acids)=367AA_start in transcript=123_stop in transcript=1226
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL

--------------------------------------------------------------
>In-frame_ENST00000236137_ENST00000543771_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(transcript)=2038nt_BP=1044nt
GGCAGAGGGTGGGCCTTAGGACGGGTCTCCCTTAAACTGGGCGATCAGGCAGCGACCCTAGAGGCGTCTGTAGGGTAAAGCTGGGGGTTC
TGTAGCCGGAGGCGGCGGCGAGTCCAGAACGTCCTGGCCTTACAGGGAGAAGGCGTCACTCGCGGTTACAAGTGCCTGACCCTCACTCCA
GTTGGCGGAGGAGGAGAAGGAAGGGGCCGGGCCGGGTCCCCTCCCCTCGCGCCCCGGATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCG
GCGGCGGCGGCGGCCACTGTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTACGGC
TTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTTCCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGGTCTTCAAT
GAAATTTATCCAGTATGGACTTACTCTTACCTGGTGCTACTGTTTCCTGTGTTCCTTGCCACAGACTACCTCCGTTATAAACCTGTTGTT
CTACTGCAGGGGCTCAGCCTTATTGTTACATGGTTTATGCTGCTCTATGCCCAGGGACTGCTGGCCATTCAATTTCTAGAATTTTTTTAT
GGCATCGCCACAGCCACTGAAATTGCCTATTACTCTTATATCTACAGTGTGGTGGACCTGGGCATGTACCAGAAAGTCACAAGTTACTGT
CGAAGTGCCACTTTGGTGGGCTTTACAGTGGGCTCTGTCCTAGGGCAAATCCTTGTCTCAGTGGCAGGCTGGTCGCTGTTCAGCCTGAAT
GTCATCTCTCTTACCTGTGTTTCAGTGGCTTTTGCTGTGGCCTGGTTTTTACCTATGCCACAGAAGAGCCTCTTCTTTCACCACATTCCT
TCTACCTGCCAGAGAGTGAATGGCATCAAGGTACAAAATGGTGGCATTGTTACTGACACCCCAGCTTCTAACCACCTTCCTGGCTGGGAG
GACATTGAGTCAAAAATCCCTCTAAATATGGAGGAGCCTCCCGTGGAGGAACCGGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTT
AAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAA
ATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAGACACAGCAACAGTAACAACAACAACAATAACAA
TGAAGGCTCACTGTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCGCCACTGTTTCAGATGCTGTTTCTCATTCTCCATGGGAG
CAGCCAGCATCGTGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGAGTCAGACCCTGGACTTTCCCTTTTGTATCTGTCATTTT
CCTCTGGATCCTCACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGACTTCCTATGTGGGGTAAAATGACTTCCTTTGATTAATG
TACTTTCTGTATCCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTGTCCTACTACAGCCTCAAAAATTGTCATTGGAATCAAAA
GCTTTCCAAGGTGCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTCCTGTAGCATGGAGGCATTATAATAGGAGTCTCAGAAGT
TACACCATTTTTCTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGAATCCACTCTATGTCTGTCAGCCTGAATCCTTCCTTCTT
GCTGCACAACAAAGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCACTCATTCATCAAAGTTCTATCTGGGTGATATATGCTATC
GAAACAGATGTGGACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTGAAGCTCATGTTATCACACATGCTGTGGGAAGAGAGGTC

>In-frame_ENST00000236137_ENST00000543771_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(amino acids)=367AA_start in transcript=123_stop in transcript=1226
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL

--------------------------------------------------------------
>In-frame_ENST00000236137_ENST00000381306_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(transcript)=2821nt_BP=1044nt
GGCAGAGGGTGGGCCTTAGGACGGGTCTCCCTTAAACTGGGCGATCAGGCAGCGACCCTAGAGGCGTCTGTAGGGTAAAGCTGGGGGTTC
TGTAGCCGGAGGCGGCGGCGAGTCCAGAACGTCCTGGCCTTACAGGGAGAAGGCGTCACTCGCGGTTACAAGTGCCTGACCCTCACTCCA
GTTGGCGGAGGAGGAGAAGGAAGGGGCCGGGCCGGGTCCCCTCCCCTCGCGCCCCGGATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCG
GCGGCGGCGGCGGCCACTGTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTACGGC
TTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTTCCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGGTCTTCAAT
GAAATTTATCCAGTATGGACTTACTCTTACCTGGTGCTACTGTTTCCTGTGTTCCTTGCCACAGACTACCTCCGTTATAAACCTGTTGTT
CTACTGCAGGGGCTCAGCCTTATTGTTACATGGTTTATGCTGCTCTATGCCCAGGGACTGCTGGCCATTCAATTTCTAGAATTTTTTTAT
GGCATCGCCACAGCCACTGAAATTGCCTATTACTCTTATATCTACAGTGTGGTGGACCTGGGCATGTACCAGAAAGTCACAAGTTACTGT
CGAAGTGCCACTTTGGTGGGCTTTACAGTGGGCTCTGTCCTAGGGCAAATCCTTGTCTCAGTGGCAGGCTGGTCGCTGTTCAGCCTGAAT
GTCATCTCTCTTACCTGTGTTTCAGTGGCTTTTGCTGTGGCCTGGTTTTTACCTATGCCACAGAAGAGCCTCTTCTTTCACCACATTCCT
TCTACCTGCCAGAGAGTGAATGGCATCAAGGTACAAAATGGTGGCATTGTTACTGACACCCCAGCTTCTAACCACCTTCCTGGCTGGGAG
GACATTGAGTCAAAAATCCCTCTAAATATGGAGGAGCCTCCCGTGGAGGAACCGGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTT
AAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAA
ATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCTGCATC
CAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGCCTTAT
GTGGTGAACATTACATGCTTTCGACATAAGGTCAACCCCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAACGGTC
ATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATGATGGC
TCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGAGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCCAAGTC
AAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGATCCCAG
ATAGCAATGAAGAGAGAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTTGTAAGTGCTGGCAGATGCCAC
TTGGGGACCTGCCAAGTGAATTCCTTGTCCTCACCTCATGTTTCCCAAGCCCAGCAGGAAACATACTTGGGCTTTTGGATTAATTCTAAA
AAAAGCCAATGCAACATTTTCCTTAGTGGAACCTATTGAATGCAAACTTCAAATTCAACCAAAATCGGGGAAATTAATGCATGTGCTTTA
CTTTTCTTCTAATGAAGTCACATGATGCTTCTTTGTGTTGACATTTATTGGTGCACAAAAATACTTACTGAATGTGTGCTCTGTGTAAAA
CACCAGGAGCAAACAAAGATACCATCAAGGCATTTGCAATCTTGTTAGTAGAAGCAACATTAAAAGTATTCAGGAGTAGATCAAAGGGGA
CTCGGCATAATTGAATGTCTGTCTATTCTTTTATAGGTTTTTCATGGATTGACTACCTTCTGTCTCAGAAAGTTACTGATGTTTGTGTCA
GTTCATCATTAAGCTAAACTCTGACTTTCATAATAAAAGGGATAAACAAAGCCTAAATGCTAGTTGTGGGAATACTAAAGCAGTTTTTTA
AAAAGGAAATAGTAGTTTCATGCCCTCACATACCATTAAAAGATGAACAAACATGGACAAATATTCAAAACTGCAGTCATTGAAAAATAT
AATTCACAATAATTTAGACTTCATATTATTGTATCATAAAATATTCAGTGGACCCTGAAATGAAGTCAGTTTTATTCATTTAGAATTATA
TCTATTGTGTCTGTGAAATGATAAATCCTAAATAGAGAAATTTGAATGGATGGGGTTTTTCTGACTAAAATGAAATTTTTTTTCTGAATA
ATTCAGTTTAGTGAGTGCTTATGATATACTTGTCTGCAGTGATAGAGTCACTATAGATTATTTGGTTATTTTGGAAAAACCAAGGGTTTT
CTTAAATCAGGGATGTCCAATCTTTTTGCATCCCTGGGCCATACTTGAAGAAGAAGAATTGTCTTTGGCCTCACATAAACTACACTAACA

>In-frame_ENST00000236137_ENST00000381306_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(amino acids)=601AA_start in transcript=123_stop in transcript=1928
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------
>In-frame_ENST00000236137_ENST00000381309_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(transcript)=2875nt_BP=1044nt
GGCAGAGGGTGGGCCTTAGGACGGGTCTCCCTTAAACTGGGCGATCAGGCAGCGACCCTAGAGGCGTCTGTAGGGTAAAGCTGGGGGTTC
TGTAGCCGGAGGCGGCGGCGAGTCCAGAACGTCCTGGCCTTACAGGGAGAAGGCGTCACTCGCGGTTACAAGTGCCTGACCCTCACTCCA
GTTGGCGGAGGAGGAGAAGGAAGGGGCCGGGCCGGGTCCCCTCCCCTCGCGCCCCGGATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCG
GCGGCGGCGGCGGCCACTGTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTACGGC
TTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTTCCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGGTCTTCAAT
GAAATTTATCCAGTATGGACTTACTCTTACCTGGTGCTACTGTTTCCTGTGTTCCTTGCCACAGACTACCTCCGTTATAAACCTGTTGTT
CTACTGCAGGGGCTCAGCCTTATTGTTACATGGTTTATGCTGCTCTATGCCCAGGGACTGCTGGCCATTCAATTTCTAGAATTTTTTTAT
GGCATCGCCACAGCCACTGAAATTGCCTATTACTCTTATATCTACAGTGTGGTGGACCTGGGCATGTACCAGAAAGTCACAAGTTACTGT
CGAAGTGCCACTTTGGTGGGCTTTACAGTGGGCTCTGTCCTAGGGCAAATCCTTGTCTCAGTGGCAGGCTGGTCGCTGTTCAGCCTGAAT
GTCATCTCTCTTACCTGTGTTTCAGTGGCTTTTGCTGTGGCCTGGTTTTTACCTATGCCACAGAAGAGCCTCTTCTTTCACCACATTCCT
TCTACCTGCCAGAGAGTGAATGGCATCAAGGTACAAAATGGTGGCATTGTTACTGACACCCCAGCTTCTAACCACCTTCCTGGCTGGGAG
GACATTGAGTCAAAAATCCCTCTAAATATGGAGGAGCCTCCCGTGGAGGAACCGGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTT
AAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAA
ATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCTGCATC
CAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGCCTTAT
GTGGTGAACATTACATGCTTTCGACATAAGGTCAACCCCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAACGGTC
ATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATGATGGC
TCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGAGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCCAAGTC
AAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGATCCCAG
ATAGCAATGAAGAGAGAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTTTCCACAGCCTCTGACATGCGA
TTTGAAGACACGTTTTATGGAGCAGACATTATCCAAGGGGAGAGAAAGAGACAAAGAGTGCTGAGCTCCAGGTTTAAGAATGAATATGTG
GCCGACCCTGTATACCGCACTTTTTTGAAGAGCTCTTTCCAGAAGAAGTGCCAGAAGAGACAGTAGTCTGCATACATCGCTGCAGGCCAC
AGAGCAGCTTGGGTTGGAAGAGAGAAGATGAAGGGACATCCTTGGGGCTGTGCCGTGAGTTTTGCTGGCATAGGTGACAGGGTGTGTCTC
TGACAGTGGTAAATCGGGTTTCCAGAGTTTGGTCACCAAAAATACAAAATACACCCAATGAATTGGACGCAGCAATCTGAAATCATCTCT
AGTCTTGCTTTCACTTGTGAGCAGTTGTCTTCTATGATCCCAAAGAAGTTTTCTAAGTGAAAGGAAATACTAGTGAATCACCCACAAGGA
AAAGCCACTGCCACAGAGGAGGCGGGTCCCCTTGTGCGGCTTAGGGCCCTGTCAGGAAACACACGGGGACCTCTCTCTCTAGCTCCAGCA
GGTGGCACCTCGGTACCCAGCGGGTAGGGCGATAATTTATATATTTTCCACAGTCAGGGAAGGACTCTCACTTATTTGTTTCAAATTGCA
GTTTTTATAAAACATTTTTAAAACACAAATGGCATGTATGCTAATGAGATTTACCCGTGTGCTATCTGTATTTCCCTTGTACAGAACTTT
TACATTTTTGAATATTCCTATTACTTTTGATTGTGTCTGATGGGAACTGAGTTGTTGGCCTTTGTGAAATGAAATTTTTGGCTCTTGAGA
AAGAATTCTTATGAATTGTTATGCGAATTTTATATATTTAAAGAGGGAGATCTGGGGCTGTTATTTTTAAACACTTTTTTTCATAATACA
TATTCCGAGTAGATATTTATAAAATATATGTTTCTTTCATTATGTGTTTGTAAAATTAGAGTTTAAATAAATATGCTTTGATGCATAGTT

>In-frame_ENST00000236137_ENST00000381309_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(amino acids)=610AA_start in transcript=123_stop in transcript=1955
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------
>In-frame_ENST00000236137_ENST00000442236_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(transcript)=2051nt_BP=1044nt
GGCAGAGGGTGGGCCTTAGGACGGGTCTCCCTTAAACTGGGCGATCAGGCAGCGACCCTAGAGGCGTCTGTAGGGTAAAGCTGGGGGTTC
TGTAGCCGGAGGCGGCGGCGAGTCCAGAACGTCCTGGCCTTACAGGGAGAAGGCGTCACTCGCGGTTACAAGTGCCTGACCCTCACTCCA
GTTGGCGGAGGAGGAGAAGGAAGGGGCCGGGCCGGGTCCCCTCCCCTCGCGCCCCGGATGGATGTGCCCGGCCCGGTGTCTCGGCGGGCG
GCGGCGGCGGCGGCCACTGTGCTCCTGCGGACCGCTCGGGTCCGTCGCGAATGCTGGTTCTTGCCGACCGCGCTGCTCTGCGCCTACGGC
TTCTTCGCCAGCCTCAGGCCGTCCGAGCCCTTCCTGACCCCGTACCTGCTGGGGCCGGACAAGAACCTGACCGAGAGGGAGGTCTTCAAT
GAAATTTATCCAGTATGGACTTACTCTTACCTGGTGCTACTGTTTCCTGTGTTCCTTGCCACAGACTACCTCCGTTATAAACCTGTTGTT
CTACTGCAGGGGCTCAGCCTTATTGTTACATGGTTTATGCTGCTCTATGCCCAGGGACTGCTGGCCATTCAATTTCTAGAATTTTTTTAT
GGCATCGCCACAGCCACTGAAATTGCCTATTACTCTTATATCTACAGTGTGGTGGACCTGGGCATGTACCAGAAAGTCACAAGTTACTGT
CGAAGTGCCACTTTGGTGGGCTTTACAGTGGGCTCTGTCCTAGGGCAAATCCTTGTCTCAGTGGCAGGCTGGTCGCTGTTCAGCCTGAAT
GTCATCTCTCTTACCTGTGTTTCAGTGGCTTTTGCTGTGGCCTGGTTTTTACCTATGCCACAGAAGAGCCTCTTCTTTCACCACATTCCT
TCTACCTGCCAGAGAGTGAATGGCATCAAGGTACAAAATGGTGGCATTGTTACTGACACCCCAGCTTCTAACCACCTTCCTGGCTGGGAG
GACATTGAGTCAAAAATCCCTCTAAATATGGAGGAGCCTCCCGTGGAGGAACCGGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTT
AAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAA
ATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGAAATGCATCTTCTGCAGACACCGGGTTAAGAGGGTCTCTGGAGCCTGCATC
CAGTGTTCCTACGGTCGCTGCCCGGCCTCCTTCCATGTCACTTGTGCCCATGCTGCTGGGGTACTGATGGAGCCTGATGACTGGCCTTAT
GTGGTGAACATTACATGCTTTCGACATAAGGTCAACCCCAACGTGAAGTCCAAGGCTTGCGAGAAGGTCATTTCCGTGGGTCAAACGGTC
ATCACGAAGCATCGGAACACCCGGTATTACAGTTGCAGAGTGATGGCTGTGACATCGCAGACCTTCTATGAGGTCATGTTTGATGATGGC
TCCTTTAGCAGAGACACATTTCCTGAGGATATCGTGAGCCGAGACTGTCTGAAGCTGGGCCCACCTGCTGAGGGAGAAGTCGTCCAAGTC
AAGTGGCCCGATGGCAAACTCTATGGAGCAAAATATTTTGGATCAAATATTGCCCACATGTACCAGGTTGAGTTTGAAGATGGATCCCAG
ATAGCAATGAAGAGAGAGGACATCTACACTTTAGATGAAGAGTTACCCAAGAGAGTGAAAGCTCGATTTTCCACAGCCTCTGACATGCGA
TTTGAAGACACGTTTTATGGAGCAGACATTATCCAAGGGGAGAGAAAGAGACAAAGAGTGCTGAGCTCCAGGTTTAAGAATGAATATGTG
GCCGACCCTGTATACCGCACTTTTTTGAAGAGCTCTTTCCAGAAGAAGTGCCAGAAGAGACAGTAGTCTGCATACATCGCTGCAGGCCAC

>In-frame_ENST00000236137_ENST00000442236_TCGA-BH-A0E1-01A_SLC19A2_chr1_169446393_-_KDM4C_chr9_7046862_length(amino acids)=610AA_start in transcript=123_stop in transcript=1955
MALQGEGVTRGYKCLTLTPVGGGGEGRGRAGSPPLAPRMDVPGPVSRRAAAAAATVLLRTARVRRECWFLPTALLCAYGFFASLRPSEPF
LTPYLLGPDKNLTEREVFNEIYPVWTYSYLVLLFPVFLATDYLRYKPVVLLQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYY
SYIYSVVDLGMYQKVTSYCRSATLVGFTVGSVLGQILVSVAGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFHHIPSTCQRVNGIKV
QNGGIVTDTPASNHLPGWEDIESKIPLNMEEPPVEEPECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRL
KLKCIFCRHRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNITCFRHKVNPNVKSKACEKVISVGQTVITKHRNTRYYS
CRVMAVTSQTFYEVMFDDGSFSRDTFPEDIVSRDCLKLGPPAEGEVVQVKWPDGKLYGAKYFGSNIAHMYQVEFEDGSQIAMKREDIYTL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC19A2-KDM4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC19A2-KDM4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC19A2-KDM4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC19A2C0342287Thiamine responsive megaloblastic anemia syndrome6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSLC19A2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC19A2C0158981Neonatal diabetes mellitus1GENOMICS_ENGLAND
TgeneKDM4CC0004565Melanoma, B161CTD_human
TgeneKDM4CC0009075Melanoma, Cloudman S911CTD_human
TgeneKDM4CC0018598Melanoma, Harding-Passey1CTD_human
TgeneKDM4CC0025149Medulloblastoma1CTD_human
TgeneKDM4CC0025202melanoma1CTD_human
TgeneKDM4CC0025205Melanoma, Experimental1CTD_human
TgeneKDM4CC0079772T-Cell Lymphoma1CTD_human
TgeneKDM4CC0205833Medullomyoblastoma1CTD_human
TgeneKDM4CC0236663Alcohol withdrawal syndrome1PSYGENET
TgeneKDM4CC0278510Childhood Medulloblastoma1CTD_human
TgeneKDM4CC0278876Adult Medulloblastoma1CTD_human
TgeneKDM4CC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneKDM4CC1275668Melanotic medulloblastoma1CTD_human