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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SLC1A2-AP4M1 (FusionGDB2 ID:81809) |
Fusion Gene Summary for SLC1A2-AP4M1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC1A2-AP4M1 | Fusion gene ID: 81809 | Hgene | Tgene | Gene symbol | SLC1A2 | AP4M1 | Gene ID | 6506 | 9179 |
| Gene name | solute carrier family 1 member 2 | adaptor related protein complex 4 subunit mu 1 | |
| Synonyms | EAAT2|EIEE41|GLT-1|HBGT | CPSQ3|MU-4|MU-ARP2|SPG50 | |
| Cytomap | 11p13 | 7q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2 | AP-4 complex subunit mu-1AP-4 adaptor complex mu subunitadapter-related protein complex 4 mu-1 subunitadapter-related protein complex 4 subunit mu-1adaptor related protein complex 4 mu 1 subunitadaptor-related protein complex AP-4 mu4 subunitmu subu | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | O00189 | |
| Ensembl transtripts involved in fusion gene | ENST00000278379, ENST00000395750, ENST00000395753, ENST00000606205, ENST00000479543, | ENST00000429084, ENST00000359593, ENST00000478501, ENST00000421755, ENST00000422582, | |
| Fusion gene scores | * DoF score | 3 X 4 X 1=12 | 4 X 4 X 3=48 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC1A2 [Title/Abstract] AND AP4M1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SLC1A2(35274643)-AP4M1(99699576), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC1A2 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
| Hgene | SLC1A2 | GO:0070207 | protein homotrimerization | 15265858|15483603 |
| Hgene | SLC1A2 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
| Hgene | SLC1A2 | GO:0098712 | L-glutamate import across plasma membrane | 7521911|15265858|26690923 |
| Tgene | AP4M1 | GO:0006605 | protein targeting | 20230749 |
| Tgene | AP4M1 | GO:0006622 | protein targeting to lysosome | 11139587 |
| Tgene | AP4M1 | GO:0090160 | Golgi to lysosome transport | 11139587 |
| Fusion gene breakpoints across SLC1A2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across AP4M1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF922824 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
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Fusion Gene ORF analysis for SLC1A2-AP4M1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000278379 | ENST00000429084 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000278379 | ENST00000359593 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000278379 | ENST00000478501 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000278379 | ENST00000421755 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-intron | ENST00000278379 | ENST00000422582 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000395750 | ENST00000429084 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000395750 | ENST00000359593 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000395750 | ENST00000478501 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000395750 | ENST00000421755 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-intron | ENST00000395750 | ENST00000422582 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000395753 | ENST00000429084 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000395753 | ENST00000359593 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000395753 | ENST00000478501 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000395753 | ENST00000421755 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-intron | ENST00000395753 | ENST00000422582 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000606205 | ENST00000429084 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000606205 | ENST00000359593 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000606205 | ENST00000478501 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000606205 | ENST00000421755 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-intron | ENST00000606205 | ENST00000422582 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000479543 | ENST00000429084 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3CDS | ENST00000479543 | ENST00000359593 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000479543 | ENST00000478501 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-3UTR | ENST00000479543 | ENST00000421755 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| intron-intron | ENST00000479543 | ENST00000422582 | SLC1A2 | chr11 | 35274643 | + | AP4M1 | chr7 | 99699576 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for SLC1A2-AP4M1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SLC1A2-AP4M1 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | AP4M1 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity). {ECO:0000250|UniProtKB:E2RED8, ECO:0000250|UniProtKB:Q2PWT8, ECO:0000250|UniProtKB:Q9JKC7, ECO:0000269|PubMed:10066790, ECO:0000269|PubMed:10436028, ECO:0000269|PubMed:11139587, ECO:0000269|PubMed:11802162, ECO:0000269|PubMed:20230749, ECO:0000269|PubMed:26544806}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for SLC1A2-AP4M1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for SLC1A2-AP4M1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SLC1A2-AP4M1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SLC1A2-AP4M1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC1A2 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
| Hgene | SLC1A2 | C0036341 | Schizophrenia | 4 | PSYGENET |
| Hgene | SLC1A2 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
| Hgene | SLC1A2 | C0011570 | Mental Depression | 3 | PSYGENET |
| Hgene | SLC1A2 | C0011581 | Depressive disorder | 3 | PSYGENET |
| Hgene | SLC1A2 | C4310717 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 41 | 3 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | SLC1A2 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
| Hgene | SLC1A2 | C0009171 | Cocaine Abuse | 1 | CTD_human |
| Hgene | SLC1A2 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Hgene | SLC1A2 | C0014544 | Epilepsy | 1 | CTD_human |
| Hgene | SLC1A2 | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human |
| Hgene | SLC1A2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
| Hgene | SLC1A2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | SLC1A2 | C0086237 | Epilepsy, Cryptogenic | 1 | CTD_human |
| Hgene | SLC1A2 | C0236018 | Aura | 1 | CTD_human |
| Hgene | SLC1A2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
| Hgene | SLC1A2 | C0393554 | Amyotrophic Lateral Sclerosis With Dementia | 1 | CTD_human |
| Hgene | SLC1A2 | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | SLC1A2 | C0543859 | Amyotrophic Lateral Sclerosis, Guam Form | 1 | CTD_human |
| Hgene | SLC1A2 | C0543888 | Epileptic encephalopathy | 1 | GENOMICS_ENGLAND |
| Hgene | SLC1A2 | C0600427 | Cocaine Dependence | 1 | CTD_human |
| Hgene | SLC1A2 | C0751111 | Awakening Epilepsy | 1 | CTD_human |
| Hgene | SLC1A2 | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human |
| Hgene | SLC1A2 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |
| Tgene | AP4M1 | C2752008 | Spastic Paraplegia-50, Autosomal Recessive | 2 | CTD_human;GENOMICS_ENGLAND |
| Tgene | AP4M1 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
| Tgene | AP4M1 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
| Tgene | AP4M1 | C0917816 | Mental deficiency | 1 | CTD_human |
| Tgene | AP4M1 | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | AP4M1 | C4755264 | Severe intellectual disability and progressive spastic paraplegia | 1 | ORPHANET |
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