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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC22A15-ATP1A1 (FusionGDB2 ID:81873)

Fusion Gene Summary for SLC22A15-ATP1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC22A15-ATP1A1
Fusion gene ID: 81873
HgeneTgene
Gene symbol

SLC22A15

ATP1A1

Gene ID

55356

480

Gene namesolute carrier family 22 member 15ATPase Na+/K+ transporting subunit alpha 4
SynonymsFLIPT1|PRO34686ATP1A1|ATP1AL2
Cytomap

1p13.1

1q23.2

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 22 member 15flipt 1fly-like putative organic ion transporter 1fly-like putative transporter 1solute carrier family 22 (organic cation transporter), member 15trans-like proteinsodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
Modification date2020031320200313
UniProtAcc.

Q5TC04

Ensembl transtripts involved in fusion geneENST00000369503, ENST00000369502, 
ENST00000481127, 		ENST00000295598, 
ENST00000537345, ENST00000369496, 
ENST00000491156, 
Fusion gene scores* DoF score4 X 3 X 4=4819 X 23 X 5=2185
# samples 424
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/2185*10)=-3.18652696877944
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC22A15 [Title/Abstract] AND ATP1A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC22A15(116519335)-ATP1A1(116926636), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

TgeneATP1A1

GO:0030641

regulation of cellular pH

12112599


check buttonFusion gene breakpoints across SLC22A15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ATP1A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A48C-01ASLC22A15chr1

116519335

+ATP1A1chr1

116926636

+


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Fusion Gene ORF analysis for SLC22A15-ATP1A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000369503ENST00000295598SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
In-frameENST00000369503ENST00000537345SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
5CDS-5UTRENST00000369503ENST00000369496SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
5CDS-intronENST00000369503ENST00000491156SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
In-frameENST00000369502ENST00000295598SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
In-frameENST00000369502ENST00000537345SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
5CDS-5UTRENST00000369502ENST00000369496SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
5CDS-intronENST00000369502ENST00000491156SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
intron-3CDSENST00000481127ENST00000295598SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
intron-3CDSENST00000481127ENST00000537345SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
intron-5UTRENST00000481127ENST00000369496SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+
intron-intronENST00000481127ENST00000491156SLC22A15chr1

116519335

+ATP1A1chr1

116926636

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369503SLC22A15chr1116519335+ENST00000295598ATP1A1chr1116926636+36072176732761069
ENST00000369503SLC22A15chr1116519335+ENST00000537345ATP1A1chr1116926636+36052176732761069
ENST00000369502SLC22A15chr1116519335+ENST00000295598ATP1A1chr1116926636+34911011431601048
ENST00000369502SLC22A15chr1116519335+ENST00000537345ATP1A1chr1116926636+34891011431601048

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369503ENST00000295598SLC22A15chr1116519335+ATP1A1chr1116926636+0.0010172670.9989827
ENST00000369503ENST00000537345SLC22A15chr1116519335+ATP1A1chr1116926636+0.0010151610.9989849
ENST00000369502ENST00000295598SLC22A15chr1116519335+ATP1A1chr1116926636+0.0010039220.9989961
ENST00000369502ENST00000537345SLC22A15chr1116519335+ATP1A1chr1116926636+0.001001370.9989986

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Fusion Genomic Features for SLC22A15-ATP1A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC22A15chr1116519335+ATP1A1chr1116926635+0.0021409190.99785906
SLC22A15chr1116519335+ATP1A1chr1116926635+0.0021409190.99785906

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC22A15-ATP1A1


check button Go to

FGviewer for the breakpoints of chr1:116519335-chr1:116926636

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATP1A1

Q5TC04

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP1A1chr1:116519335chr1:116926636ENST0000029559802382_844.01024.0RegionPhosphoinositide-3 kinase binding
TgeneATP1A1chr1:116519335chr1:116926636ENST0000036949602382_840993.0RegionPhosphoinositide-3 kinase binding
TgeneATP1A1chr1:116519335chr1:116926636ENST0000053734502382_844.01024.0RegionPhosphoinositide-3 kinase binding
TgeneATP1A1chr1:116519335chr1:116926636ENST000002955980231007_10234.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023109_1314.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023153_2884.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023309_3204.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023339_7724.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST000002955980236_874.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023793_8024.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023824_8434.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023867_9184.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023939_9514.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023971_9854.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST000003694960231007_10230993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023109_1310993.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023153_2880993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023309_3200993.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023339_7720993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST000003694960236_870993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023793_8020993.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023824_8430993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023867_9180993.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023939_9510993.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023971_9850993.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST000005373450231007_10234.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023109_1314.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023153_2884.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023309_3204.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023339_7724.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST000005373450236_874.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023793_8024.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023824_8434.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023867_9184.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023939_9514.01024.0Topological domainCytoplasmic
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023971_9854.01024.0Topological domainExtracellular
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023132_1524.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023289_3084.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023321_3384.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023773_7924.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023803_8234.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023844_8664.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST0000029559802388_1084.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023919_9384.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023952_9704.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000295598023986_10064.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023132_1520993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023289_3080993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023321_3380993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023773_7920993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023803_8230993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023844_8660993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST0000036949602388_1080993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023919_9380993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023952_9700993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000369496023986_10060993.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023132_1524.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023289_3084.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023321_3384.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023773_7924.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023803_8234.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023844_8664.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST0000053734502388_1084.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023919_9384.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023952_9704.01024.0TransmembraneHelical
TgeneATP1A1chr1:116519335chr1:116926636ENST00000537345023986_10064.01024.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16529_53529.0246.0Compositional biasNote=Poly-Glu
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112529_53529.0548.0Compositional biasNote=Poly-Glu
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16111_13129.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16141_16129.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16165_18729.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16201_22129.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16226_24629.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+1622_4229.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16303_32329.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16338_35829.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16368_38829.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16401_42029.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16433_45329.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369502+16462_48229.0246.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112111_13129.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112141_16129.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112165_18729.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112201_22129.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112226_24629.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+11222_4229.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112303_32329.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112338_35829.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112368_38829.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112401_42029.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112433_45329.0548.0TransmembraneHelical
HgeneSLC22A15chr1:116519335chr1:116926636ENST00000369503+112462_48229.0548.0TransmembraneHelical


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Fusion Gene Sequence for SLC22A15-ATP1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000369503_ENST00000295598_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(transcript)=3607nt_BP=217nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAA
GGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCA
TCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCC
CCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTT
CTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCAT
AACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGAT
TCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGA
CCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCAC
AAATGAAAACCCCCTGGAGACGAGGAACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGG
GGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTAT
CCACATCATCACGGGTGTGGCTGTGTTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCAT
CTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGC
AAGGAAAAACTGCTTAGTGAAGAACTTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGAC
TCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGA
CAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTAT
TCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGA
AAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCA
ACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGA
GGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGA
TGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGAT
TGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAAT
CACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGT
CAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTT
GAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGT
GGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTC
CAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTT
GAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACT
GGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCAT
GAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGC
CCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGA
CCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTT
CTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAA
GATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCC
CCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACG
CCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACAC
CCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTG
GAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGT
GCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTAT

>In-frame_ENST00000369503_ENST00000295598_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(amino acids)=1069AA_start in transcript=67_stop in transcript=3276
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH
KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGV
VLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEP
QTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILE
YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE
NQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHK
NPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLC
FVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMT
SEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEE
GRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAY
GQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSV

--------------------------------------------------------------
>In-frame_ENST00000369503_ENST00000537345_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(transcript)=3605nt_BP=217nt
GCCGCCAGCGCTTCCATCCCCGCCCCGGCGGGTCCAAGCCGGTGCCGGGCGCCCAGGGGTTGCCGCGCTGGGCGGGAGGGCAGCGCCTGA
GAGGGCGGTGGGGTGGCGGGGTTCCTGCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCA
GATGTACTTGTGCTTCCTGCTGGCCGTGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAA
GGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCA
TCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCC
CCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTT
CTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCAT
AACTGGTTGCTTCTCCTACTATCAAGAAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGAT
TCGAAATGGTGAGAAAATGAGCATAAATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGA
CCTCAGAATCATATCTGCAAATGGCTGCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCAC
AAATGAAAACCCCCTGGAGACGAGGAACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGG
GGATCGCACTGTGATGGGAAGAATTGCCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTAT
CCACATCATCACGGGTGTGGCTGTGTTCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCAT
CTTCCTCATCGGTATCATCGTAGCCAATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGC
AAGGAAAAACTGCTTAGTGAAGAACTTAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGAC
TCAGAACCGGATGACAGTGGCCCACATGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGA
CAAGACTTCAGCTACCTGGCTTGCTCTGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTAT
TCTTAAGCGGGCAGTTGCAGGAGATGCCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGA
AAGATACGCCAAAATCGTCGAGATACCCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCA
ACACCTGTTGGTGATGAAGGGCGCCCCAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGA
GGAGCTGAAAGACGCCTTTCAGAACGCCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGA
TGAACAGTTTCCTGAAGGGTTCCAGTTTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGAT
TGACCCTCCACGGGCGGCCGTTCCTGATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAAT
CACAGCTAAAGCTATTGCCAAAGGTGTGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGT
CAGCCAGGTGAACCCCAGGGATGCCAAGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTT
GAAGTACCACACTGAGATAGTGTTTGCCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGT
GGCTGTGACTGGTGACGGTGTGAATGACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTC
CAAGCAAGCTGCTGACATGATTCTTCTGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTT
GAAGAAATCCATTGCTTATACCTTAACCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACT
GGGGACTGTCACCATCCTCTGCATTGACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCAT
GAAGAGACAGCCCAGAAATCCCAAAACAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGC
CCTGGGAGGCTTCTTTACTTACTTTGTGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGA
CCGCTGGATCAACGATGTGGAAGACAGCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTT
CTTCGTCAGTATCGTGGTGGTGCAGTGGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAA
GATCTTGATATTTGGCCTCTTTGAAGAGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCC
CCTCAAACCTACCTGGTGGTTCTGTGCCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACG
CCCTGGCGGCTGGGTGGAGAAGGAAACCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACAC
CCACCCCCTCTTTGTGTACTTCAGTCTTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTG
GAATGAAGCATGTAGCTCTATGGGGGGAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGT
GCCTTTTTGTTTTTGTAAAAAAGGAACACCCGGAAAGACTGAAAGAATACATTTTATATCTGGATTTTTACAAATAAAGATGGCTATTAT

>In-frame_ENST00000369503_ENST00000537345_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(amino acids)=1069AA_start in transcript=67_stop in transcript=3276
MGGRAAPERAVGWRGSCARPAMEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDH
KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGV
VLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEP
QTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILE
YTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE
NQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHK
NPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLC
FVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMT
SEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEE
GRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAY
GQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSV

--------------------------------------------------------------
>In-frame_ENST00000369502_ENST00000295598_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(transcript)=3491nt_BP=101nt
GCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCAGATGTACTTGTGCTTCCTGCTGGCCG
TGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGG
ACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCC
GGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCA
AGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTA
CAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAG
AAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAA
ATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCT
GCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGGA
ACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGGGGATCGCACTGTGATGGGAAGAATTG
CCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGT
TCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGTATCATCGTAGCCA
ATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAACT
TAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGACTCAGAACCGGATGACAGTGGCCCACA
TGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTC
TGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATG
CCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATAC
CCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCC
CAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACG
CCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGT
TTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTG
ATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTG
TGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCA
AGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTG
CCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATG
ACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTC
TGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAA
CCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTG
ACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAA
CAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTG
TGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACA
GCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGT
GGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAG
AGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTG
CCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAA
CCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTC
TTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGG
GAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAA

>In-frame_ENST00000369502_ENST00000295598_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(amino acids)=1048AA_start in transcript=14_stop in transcript=3160
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTS
ARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSS
KIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFF
STNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEG
LLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIA
GLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERIL
DRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGK
CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSP
QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP
EITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAE
NGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALA

--------------------------------------------------------------
>In-frame_ENST00000369502_ENST00000537345_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(transcript)=3489nt_BP=101nt
GCGCGCGGCCCGCCATGGAGGTGGAGGAGGCGTTCCAGGCGGTGGGGGAGATGGGCATCTACCAGATGTACTTGTGCTTCCTGCTGGCCG
TGCTGCTGCAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGG
ACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCC
GGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCA
AGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTA
CAGAAGAGGAACCTCAAAACGATAATCTGTACCTGGGTGTGGTGCTATCAGCCGTTGTAATCATAACTGGTTGCTTCTCCTACTATCAAG
AAGCTAAAAGTTCAAAGATCATGGAATCCTTCAAAAACATGGTCCCTCAGCAAGCCCTTGTGATTCGAAATGGTGAGAAAATGAGCATAA
ATGCGGAGGAAGTTGTGGTTGGGGATCTGGTGGAAGTAAAAGGAGGAGACCGAATTCCTGCTGACCTCAGAATCATATCTGCAAATGGCT
GCAAGGTGGATAACTCCTCGCTCACTGGTGAATCAGAACCCCAGACTAGGTCTCCAGATTTCACAAATGAAAACCCCCTGGAGACGAGGA
ACATTGCCTTCTTTTCAACCAATTGTGTTGAAGGCACCGCACGTGGTATTGTTGTCTACACTGGGGATCGCACTGTGATGGGAAGAATTG
CCACACTTGCTTCTGGGCTGGAAGGAGGCCAGACCCCCATTGCTGCAGAAATTGAACATTTTATCCACATCATCACGGGTGTGGCTGTGT
TCCTGGGTGTGTCTTTCTTCATCCTTTCTCTCATCCTTGAGTACACCTGGCTTGAGGCTGTCATCTTCCTCATCGGTATCATCGTAGCCA
ATGTGCCGGAAGGTTTGCTGGCCACTGTCACGGTCTGTCTGACACTTACTGCCAAACGCATGGCAAGGAAAAACTGCTTAGTGAAGAACT
TAGAAGCTGTGGAGACCTTGGGGTCCACGTCCACCATCTGCTCTGATAAAACTGGAACTCTGACTCAGAACCGGATGACAGTGGCCCACA
TGTGGTTTGACAATCAAATCCATGAAGCTGATACGACAGAGAATCAGAGTGGTGTCTCTTTTGACAAGACTTCAGCTACCTGGCTTGCTC
TGTCCAGAATTGCAGGTCTTTGTAACAGGGCAGTGTTTCAGGCTAACCAGGAAAACCTACCTATTCTTAAGCGGGCAGTTGCAGGAGATG
CCTCTGAGTCAGCACTCTTAAAGTGCATAGAGCTGTGCTGTGGTTCCGTGAAGGAGATGAGAGAAAGATACGCCAAAATCGTCGAGATAC
CCTTCAACTCCACCAACAAGTACCAGTTGTCTATTCATAAGAACCCCAACACATCGGAGCCCCAACACCTGTTGGTGATGAAGGGCGCCC
CAGAAAGGATCCTAGACCGTTGCAGCTCTATCCTCCTCCACGGCAAGGAGCAGCCCCTGGATGAGGAGCTGAAAGACGCCTTTCAGAACG
CCTATTTGGAGCTGGGGGGCCTCGGAGAACGAGTCCTAGGTTTCTGCCACCTCTTTCTGCCAGATGAACAGTTTCCTGAAGGGTTCCAGT
TTGACACTGACGATGTGAATTTCCCTATCGATAATCTGTGCTTTGTTGGGCTCATCTCCATGATTGACCCTCCACGGGCGGCCGTTCCTG
ATGCCGTGGGCAAATGTCGAAGTGCTGGAATTAAGGTCATCATGGTCACAGGAGACCATCCAATCACAGCTAAAGCTATTGCCAAAGGTG
TGGGCATCATCTCAGAAGGCAATGAGACCGTGGAAGACATTGCTGCCCGCCTCAACATCCCAGTCAGCCAGGTGAACCCCAGGGATGCCA
AGGCCTGCGTAGTACACGGCAGTGATCTAAAGGACATGACCTCCGAGCAGCTGGATGACATTTTGAAGTACCACACTGAGATAGTGTTTG
CCAGGACCTCCCCTCAGCAGAAGCTCATCATTGTGGAAGGCTGCCAAAGACAGGGTGCTATCGTGGCTGTGACTGGTGACGGTGTGAATG
ACTCTCCAGCTTTGAAGAAAGCAGACATTGGGGTTGCTATGGGGATTGCTGGCTCAGATGTGTCCAAGCAAGCTGCTGACATGATTCTTC
TGGATGACAACTTTGCCTCAATTGTGACTGGAGTAGAGGAAGGTCGTCTGATCTTTGATAACTTGAAGAAATCCATTGCTTATACCTTAA
CCAGTAACATTCCCGAGATCACCCCGTTCCTGATATTTATTATTGCAAACATTCCACTACCACTGGGGACTGTCACCATCCTCTGCATTG
ACTTGGGCACTGACATGGTTCCTGCCATCTCCCTGGCTTATGAGCAGGCTGAGAGTGACATCATGAAGAGACAGCCCAGAAATCCCAAAA
CAGACAAACTTGTGAATGAGCGGCTGATCAGCATGGCCTATGGGCAGATTGGAATGATCCAGGCCCTGGGAGGCTTCTTTACTTACTTTG
TGATTCTGGCTGAGAACGGCTTCCTCCCAATTCACCTGTTGGGCCTCCGAGTGGACTGGGATGACCGCTGGATCAACGATGTGGAAGACA
GCTACGGGCAGCAGTGGACCTATGAGCAGAGGAAAATCGTGGAGTTCACCTGCCACACAGCCTTCTTCGTCAGTATCGTGGTGGTGCAGT
GGGCCGACTTGGTCATCTGTAAGACCAGGAGGAATTCGGTCTTCCAGCAGGGGATGAAGAACAAGATCTTGATATTTGGCCTCTTTGAAG
AGACAGCCCTGGCTGCTTTCCTTTCCTACTGCCCTGGAATGGGTGTTGCTCTTAGGATGTATCCCCTCAAACCTACCTGGTGGTTCTGTG
CCTTCCCCTACTCTCTTCTCATCTTCGTATATGACGAAGTCAGAAAACTCATCATCAGGCGACGCCCTGGCGGCTGGGTGGAGAAGGAAA
CCTACTATTAGCCCCCCGTCCTGCACGCCGTGGAGCATCAGGCCACACACTCTGCATCCGACACCCACCCCCTCTTTGTGTACTTCAGTC
TTGGAGTTTGGAACTCTACCCTGGTAGGAAAGCACCGCAGCATGTGGGGAAGCAAGACGTCCTGGAATGAAGCATGTAGCTCTATGGGGG
GAGGGGGGAGGGCTGCCTGAAAACCATCCATCTGTGGAAATGACAGCGGGGAAGGTTTTTATGTGCCTTTTTGTTTTTGTAAAAAAGGAA

>In-frame_ENST00000369502_ENST00000537345_TCGA-CD-A48C-01A_SLC22A15_chr1_116519335_+_ATP1A1_chr1_116926636_length(amino acids)=1048AA_start in transcript=14_stop in transcript=3160
MEVEEAFQAVGEMGIYQMYLCFLLAVLLQVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTS
ARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSS
KIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFF
STNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEG
LLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIA
GLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERIL
DRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGK
CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSP
QQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIP
EITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAE
NGFLPIHLLGLRVDWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALA

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Fusion Gene PPI Analysis for SLC22A15-ATP1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC22A15-ATP1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC22A15-ATP1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC22A15C0009402Colorectal Carcinoma1CTD_human
HgeneSLC22A15C0009404Colorectal Neoplasms1CTD_human
TgeneATP1A1C0001430Adenoma2CTD_human
TgeneATP1A1C0205646Adenoma, Basal Cell2CTD_human
TgeneATP1A1C0205647Follicular adenoma2CTD_human
TgeneATP1A1C0205648Adenoma, Microcystic2CTD_human
TgeneATP1A1C0205649Adenoma, Monomorphic2CTD_human
TgeneATP1A1C0205650Papillary adenoma2CTD_human
TgeneATP1A1C0205651Adenoma, Trabecular2CTD_human
TgeneATP1A1C4747974CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2DD2GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneATP1A1C0005586Bipolar Disorder1PSYGENET
TgeneATP1A1C0017162Gastroenteritis, Transmissible, of Swine1CTD_human
TgeneATP1A1C0020428Hyperaldosteronism1CTD_human
TgeneATP1A1C0020538Hypertensive disease1CTD_human
TgeneATP1A1C0027051Myocardial Infarction1CTD_human
TgeneATP1A1C0027055Myocardial Reperfusion Injury1CTD_human
TgeneATP1A1C0036572Seizures1GENOMICS_ENGLAND
TgeneATP1A1C0042594Vestibular Diseases1CTD_human
TgeneATP1A1C0151723Hypomagnesemia1GENOMICS_ENGLAND
TgeneATP1A1C0151744Myocardial Ischemia1CTD_human
TgeneATP1A1C1384514Conn Syndrome1CTD_human
TgeneATP1A1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneATP1A1C4552839Hypomagnesemia, CTCAE1GENOMICS_ENGLAND