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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A24-DHRS12 (FusionGDB2 ID:82035)

Fusion Gene Summary for SLC25A24-DHRS12

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A24-DHRS12
Fusion gene ID: 82035
HgeneTgene
Gene symbol

SLC25A24

DHRS12

Gene ID

29957

79758

Gene namesolute carrier family 25 member 24dehydrogenase/reductase 12
SynonymsAPC1|SCAMC-1|SCAMC1SDR40C1
Cytomap

1p13.3

13q14.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding mitochondrial carrier protein SCaMC-1calcium-binding transportermitochondrial ATP-Mg/Pi carrier protein 1mitochondrial Ca(2+)-dependent solute carrier protein 1short calcium-binding mitochondrial carrier 1small calcium-binding mitochodehydrogenase/reductase SDR family member 12dehydrogenase/reductase (SDR family) member 12short-chain dehydrogenase/reductase family 40C member 1
Modification date2020031320200313
UniProtAcc.

A0PJE2

Ensembl transtripts involved in fusion geneENST00000565488, ENST00000370041, 
ENST00000569674, 		ENST00000444610, 
ENST00000218981, ENST00000280056, 
ENST00000490949, 
Fusion gene scores* DoF score1 X 2 X 1=24 X 3 X 3=36
# samples 25
** MAII scorelog2(2/2*10)=3.32192809488736log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC25A24 [Title/Abstract] AND DHRS12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A24(108724563)-DHRS12(52373803), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC25A24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DHRS12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A2LL-01ASLC25A24chr1

108724563

-DHRS12chr13

52373803

-
ChimerDB4BRCATCGA-AR-A2LLSLC25A24chr1

108724562

-DHRS12chr13

52373803

-
ChimerDB4BRCATCGA-AR-A2LL-01ASLC25A24chr1

108724563

-DHRS12chr13

52373803

-
ChimerDB4BRCATCGA-AR-A2LL-01ASLC25A24chr1

108724563

-DHRS12chr13

52373803

-


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Fusion Gene ORF analysis for SLC25A24-DHRS12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000565488ENST00000444610SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000218981SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000280056SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000490949SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
In-frameENST00000370041ENST00000444610SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000218981SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000280056SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000490949SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
intron-3CDSENST00000569674ENST00000444610SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000218981SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000280056SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000490949SLC25A24chr1

108724563

-DHRS12chr13

52373803

-
In-frameENST00000565488ENST00000444610SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000218981SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000280056SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000565488ENST00000490949SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
In-frameENST00000370041ENST00000444610SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000218981SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000280056SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
5CDS-5UTRENST00000370041ENST00000490949SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
intron-3CDSENST00000569674ENST00000444610SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000218981SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000280056SLC25A24chr1

108724562

-DHRS12chr13

52373803

-
intron-5UTRENST00000569674ENST00000490949SLC25A24chr1

108724562

-DHRS12chr13

52373803

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000565488SLC25A24chr1108724563-ENST00000444610DHRS12chr1352373803-1710618701515481
ENST00000370041SLC25A24chr1108724563-ENST00000444610DHRS12chr1352373803-16305381971435412
ENST00000565488SLC25A24chr1108724562-ENST00000444610DHRS12chr1352373803-1710618701515481
ENST00000370041SLC25A24chr1108724562-ENST00000444610DHRS12chr1352373803-16305381971435412

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000565488ENST00000444610SLC25A24chr1108724563-DHRS12chr1352373803-0.0037877120.99621236
ENST00000370041ENST00000444610SLC25A24chr1108724563-DHRS12chr1352373803-0.0008810770.99911886
ENST00000565488ENST00000444610SLC25A24chr1108724562-DHRS12chr1352373803-0.0037877120.99621236
ENST00000370041ENST00000444610SLC25A24chr1108724562-DHRS12chr1352373803-0.0008810770.99911886

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Fusion Genomic Features for SLC25A24-DHRS12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC25A24-DHRS12


check button Go to

FGviewer for the breakpoints of chr1:108724563-chr13:52373803

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DHRS12

A0PJE2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Putative oxidoreductase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31032_43113.66666666666667459.0Calcium bindingNote=1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31068_79113.66666666666667459.0Calcium bindingNote=2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31099_110113.66666666666667459.0Calcium bindingNote=3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31032_43132.66666666666666478.0Calcium bindingNote=1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31068_79132.66666666666666478.0Calcium bindingNote=2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31099_110132.66666666666666478.0Calcium bindingNote=3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31032_43113.66666666666667459.0Calcium bindingNote=1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31068_79113.66666666666667459.0Calcium bindingNote=2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31099_110113.66666666666667459.0Calcium bindingNote=3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31032_43132.66666666666666478.0Calcium bindingNote=1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31068_79132.66666666666666478.0Calcium bindingNote=2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31099_110132.66666666666666478.0Calcium bindingNote=3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31019_54113.66666666666667459.0DomainEF-hand 1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31055_88113.66666666666667459.0DomainEF-hand 2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31019_54132.66666666666666478.0DomainEF-hand 1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31055_88132.66666666666666478.0DomainEF-hand 2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-31086_121132.66666666666666478.0DomainEF-hand 3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31019_54113.66666666666667459.0DomainEF-hand 1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31055_88113.66666666666667459.0DomainEF-hand 2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31019_54132.66666666666666478.0DomainEF-hand 1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31055_88132.66666666666666478.0DomainEF-hand 2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-31086_121132.66666666666666478.0DomainEF-hand 3
TgeneDHRS12chr1:108724562chr13:52373803ENST000002189810847_530243.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr1:108724562chr13:52373803ENST000002800560847_530272.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr1:108724562chr13:52373803ENST0000044461001047_5318.666666666666668318.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr1:108724563chr13:52373803ENST000002189810847_530243.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr1:108724563chr13:52373803ENST000002800560847_530272.0Nucleotide bindingNAD or NADP
TgeneDHRS12chr1:108724563chr13:52373803ENST0000044461001047_5318.666666666666668318.0Nucleotide bindingNAD or NADP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310135_146113.66666666666667459.0Calcium bindingNote=4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310135_146132.66666666666666478.0Calcium bindingNote=4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310135_146113.66666666666667459.0Calcium bindingNote=4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310135_146132.66666666666666478.0Calcium bindingNote=4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310122_157113.66666666666667459.0DomainEF-hand 4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-31086_121113.66666666666667459.0DomainEF-hand 3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310122_157132.66666666666666478.0DomainEF-hand 4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310122_157113.66666666666667459.0DomainEF-hand 4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-31086_121113.66666666666667459.0DomainEF-hand 3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310122_157132.66666666666666478.0DomainEF-hand 4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310192_278113.66666666666667459.0RepeatNote=Solcar 1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310286_371113.66666666666667459.0RepeatNote=Solcar 2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310383_471113.66666666666667459.0RepeatNote=Solcar 3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310192_278132.66666666666666478.0RepeatNote=Solcar 1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310286_371132.66666666666666478.0RepeatNote=Solcar 2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310383_471132.66666666666666478.0RepeatNote=Solcar 3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310192_278113.66666666666667459.0RepeatNote=Solcar 1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310286_371113.66666666666667459.0RepeatNote=Solcar 2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310383_471113.66666666666667459.0RepeatNote=Solcar 3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310192_278132.66666666666666478.0RepeatNote=Solcar 1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310286_371132.66666666666666478.0RepeatNote=Solcar 2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310383_471132.66666666666666478.0RepeatNote=Solcar 3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-3101_197113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310216_252113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310273_295113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310310_345113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310366_388113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310407_445113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310466_477113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-3101_197132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310216_252132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310273_295132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310310_345132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310366_388132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310407_445132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310466_477132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-3101_197113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310216_252113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310273_295113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310310_345113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310366_388113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310407_445113.66666666666667459.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310466_477113.66666666666667459.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-3101_197132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310216_252132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310273_295132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310310_345132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310366_388132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310407_445132.66666666666666478.0Topological domainMitochondrial matrix
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310466_477132.66666666666666478.0Topological domainMitochondrial intermembrane
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310198_215113.66666666666667459.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310253_272113.66666666666667459.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310296_309113.66666666666667459.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310346_365113.66666666666667459.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310389_406113.66666666666667459.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000370041-310446_465113.66666666666667459.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310198_215132.66666666666666478.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310253_272132.66666666666666478.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310296_309132.66666666666666478.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310346_365132.66666666666666478.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310389_406132.66666666666666478.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A24chr1:108724562chr13:52373803ENST00000565488-310446_465132.66666666666666478.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310198_215113.66666666666667459.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310253_272113.66666666666667459.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310296_309113.66666666666667459.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310346_365113.66666666666667459.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310389_406113.66666666666667459.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000370041-310446_465113.66666666666667459.0TransmembraneHelical%3B Name%3D6
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310198_215132.66666666666666478.0TransmembraneHelical%3B Name%3D1
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310253_272132.66666666666666478.0TransmembraneHelical%3B Name%3D2
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310296_309132.66666666666666478.0TransmembraneHelical%3B Name%3D3
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310346_365132.66666666666666478.0TransmembraneHelical%3B Name%3D4
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310389_406132.66666666666666478.0TransmembraneHelical%3B Name%3D5
HgeneSLC25A24chr1:108724563chr13:52373803ENST00000565488-310446_465132.66666666666666478.0TransmembraneHelical%3B Name%3D6


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Fusion Gene Sequence for SLC25A24-DHRS12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000565488_ENST00000444610_TCGA-AR-A2LL-01A_SLC25A24_chr1_108724563_-_DHRS12_chr13_52373803_length(transcript)=1710nt_BP=618nt
AGCGGCGGGACGGCCACACCCTGCGCTCCGCGCGGGCTCGGGTGGGGTCTCCGCTCCTGCGCCCTGCGCCCTGCGCGCCGCAGCCGCAAC
CCCGACGGCGCCCCAAACGCTGTTGCGCCGCGCGCCCCGCCCAGCCCGGCCTCGCGCTGGTCCCGGTCTCGCCCCGCAGCCCTCGATCTC
CCGTGACTTCCTCGGCCAGGCCGCCTGCGCCTCTGGGACCATGTTGCGCTGGCTGCGGGACTTCGTGCTGCCCACCGCGGCCTGCCAGGA
CGCGGAGCAGCCGACGCGCTACGAGACCCTCTTCCAGGCACTGGACCGCAATGGGGACGGAGTGGTGGACATCGGCGAGCTGCAGGAGGG
GCTCAGGAACCTGGGCATCCCTCTGGGCCAGGACGCCGAGGAGAAAATTTTTACTACTGGAGATGTCAACAAAGATGGGAAGCTGGATTT
TGAAGAATTTATGAAGTACCTTAAAGACCATGAGAAGAAAATGAAATTGGCATTTAAGAGTTTAGACAAAAATAATGATGGAAAAATTGA
GGCTTCAGAAATTGTCCAGTCTCTCCAGACACTGGGTCTGACTATTTCTGAACAACAAGCAGAGTTGATTCTTCAAAGGAGTGGCTATGA
ATCTGCATGTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGG
CAAAGCAACTGCCCTTGAAATCGCCAAGCGAGGTGGCACAGTTCACCTGGTTTGTCGAGATCAAGCCCCAGCAGAAGATGCCAGGGGTGA
GATCATCCGGGAGAGCGGTAACCAGAACATTTTTCTGCACATTGTGGACTTGTCTGATCCCAAGCAAATCTGGAAATTTGTTGAAAATTT
CAAGCAGGAACATAAACTCCATGTTCTGATCAATAATGCAGGTTGCATGGTCAATAAAAGAGAGCTCACAGAAGATGGACTTGAAAAAAA
CTTTGCTGCCAATACTCTGGGTGTGTACATTCTCACGACCGGCCTGATCCCTGTGCTGGAGAAAGAACACGACCCCCGAGTGATAACCGT
CTCCTCAGGAGGAATGTTGGTTCAGAAACTGAACACCAATGATCTCCAGTCCGAAAGAACACCATTTGATGGAACTATGGTCTATGCACA
AAACAAGAGGCAGCAAGTGGTTCTGACGGAGCGGTGGGCCCAAGGGCACCCGGCCATCCATTTTTCTTCCATGCATCCTGGCTGGGCCGA
CACCCCAGGTGTGAGGCAGGCGATGCCGGGGTTCCACGCCAGGTTCGGGGACCGCCTGCGCTCCGAGGCCCAGGGCGCGGACACCATGCT
GTGGCTGGCCCTCTCCTCTGCCGCAGCCGCACAGCCCAGCGGCCGCTTCTTTCAAGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGC
TACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACAC
AGTGCGGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAA
GACGTTGTGCCTCACAGCGAGGCCTACAAGGGATGGGAACTTTTATTTCAAAATAAATACTACCGAGGCTGTGATCAGGCTCACCTTGAA

>In-frame_ENST00000565488_ENST00000444610_TCGA-AR-A2LL-01A_SLC25A24_chr1_108724563_-_DHRS12_chr13_52373803_length(amino acids)=481AA_start in transcript=70_stop in transcript=1515
MRAAAATPTAPQTLLRRAPRPARPRAGPGLAPQPSISRDFLGQAACASGTMLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVD
IGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELI
LQRSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPKQI
WKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFD
GTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPV

--------------------------------------------------------------
>In-frame_ENST00000370041_ENST00000444610_TCGA-AR-A2LL-01A_SLC25A24_chr1_108724563_-_DHRS12_chr13_52373803_length(transcript)=1630nt_BP=538nt
GAAGCCGTTAGGATGAGCCCTCTCCTTCCAGAGCTTTAACCGATGAAGGTGCATTGTGTTTGGCGCCCCTGAGGAGGATGCTGTCTTAGG
CCTCTTCCCACTGGACGTGTGTGGTGGGCAGAGATCCCGTTCGTCGGTCGCACTTCCACCCCGCTGGGGCTCACTCAGGCCGCGGAGCTG
CGAGGGAGACATCCTCGATGGACTCCCTCTACGGAGATCTCTTTTGGTACCTGGACTATAACAAGGATGGGACCTTGGACATTTTTGAGC
TTCAGGAAGGCCTGGAGGATGTAGGGGCCATTCAATCTCTAGAGGAAGCGAAGAAAATTTTTACTACTGGAGATGTCAACAAAGATGGGA
AGCTGGATTTTGAAGAATTTATGAAGTACCTTAAAGACCATGAGAAGAAAATGAAATTGGCATTTAAGAGTTTAGACAAAAATAATGATG
GAAAAATTGAGGCTTCAGAAATTGTCCAGTCTCTCCAGACACTGGGTCTGACTATTTCTGAACAACAAGCAGAGTTGATTCTTCAAAGGA
GTGGCTATGAATCTGCATGTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACA
GCGGCATTGGCAAAGCAACTGCCCTTGAAATCGCCAAGCGAGGTGGCACAGTTCACCTGGTTTGTCGAGATCAAGCCCCAGCAGAAGATG
CCAGGGGTGAGATCATCCGGGAGAGCGGTAACCAGAACATTTTTCTGCACATTGTGGACTTGTCTGATCCCAAGCAAATCTGGAAATTTG
TTGAAAATTTCAAGCAGGAACATAAACTCCATGTTCTGATCAATAATGCAGGTTGCATGGTCAATAAAAGAGAGCTCACAGAAGATGGAC
TTGAAAAAAACTTTGCTGCCAATACTCTGGGTGTGTACATTCTCACGACCGGCCTGATCCCTGTGCTGGAGAAAGAACACGACCCCCGAG
TGATAACCGTCTCCTCAGGAGGAATGTTGGTTCAGAAACTGAACACCAATGATCTCCAGTCCGAAAGAACACCATTTGATGGAACTATGG
TCTATGCACAAAACAAGAGGCAGCAAGTGGTTCTGACGGAGCGGTGGGCCCAAGGGCACCCGGCCATCCATTTTTCTTCCATGCATCCTG
GCTGGGCCGACACCCCAGGTGTGAGGCAGGCGATGCCGGGGTTCCACGCCAGGTTCGGGGACCGCCTGCGCTCCGAGGCCCAGGGCGCGG
ACACCATGCTGTGGCTGGCCCTCTCCTCTGCCGCAGCCGCACAGCCCAGCGGCCGCTTCTTTCAAGATCGGAAGCCAGTTTCTACACACT
TGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCA
ACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACT
TCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAAGGGATGGGAACTTTTATTTCAAAATAAATACTACCGAGGCTGTGATCAGGC

>In-frame_ENST00000370041_ENST00000444610_TCGA-AR-A2LL-01A_SLC25A24_chr1_108724563_-_DHRS12_chr13_52373803_length(amino acids)=412AA_start in transcript=197_stop in transcript=1435
MDSLYGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEAS
EIVQSLQTLGLTISEQQAELILQRSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEII
RESGNQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSS
GGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWL

--------------------------------------------------------------
>In-frame_ENST00000565488_ENST00000444610_TCGA-AR-A2LL_SLC25A24_chr1_108724562_-_DHRS12_chr13_52373803_length(transcript)=1710nt_BP=618nt
AGCGGCGGGACGGCCACACCCTGCGCTCCGCGCGGGCTCGGGTGGGGTCTCCGCTCCTGCGCCCTGCGCCCTGCGCGCCGCAGCCGCAAC
CCCGACGGCGCCCCAAACGCTGTTGCGCCGCGCGCCCCGCCCAGCCCGGCCTCGCGCTGGTCCCGGTCTCGCCCCGCAGCCCTCGATCTC
CCGTGACTTCCTCGGCCAGGCCGCCTGCGCCTCTGGGACCATGTTGCGCTGGCTGCGGGACTTCGTGCTGCCCACCGCGGCCTGCCAGGA
CGCGGAGCAGCCGACGCGCTACGAGACCCTCTTCCAGGCACTGGACCGCAATGGGGACGGAGTGGTGGACATCGGCGAGCTGCAGGAGGG
GCTCAGGAACCTGGGCATCCCTCTGGGCCAGGACGCCGAGGAGAAAATTTTTACTACTGGAGATGTCAACAAAGATGGGAAGCTGGATTT
TGAAGAATTTATGAAGTACCTTAAAGACCATGAGAAGAAAATGAAATTGGCATTTAAGAGTTTAGACAAAAATAATGATGGAAAAATTGA
GGCTTCAGAAATTGTCCAGTCTCTCCAGACACTGGGTCTGACTATTTCTGAACAACAAGCAGAGTTGATTCTTCAAAGGAGTGGCTATGA
ATCTGCATGTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACAGCGGCATTGG
CAAAGCAACTGCCCTTGAAATCGCCAAGCGAGGTGGCACAGTTCACCTGGTTTGTCGAGATCAAGCCCCAGCAGAAGATGCCAGGGGTGA
GATCATCCGGGAGAGCGGTAACCAGAACATTTTTCTGCACATTGTGGACTTGTCTGATCCCAAGCAAATCTGGAAATTTGTTGAAAATTT
CAAGCAGGAACATAAACTCCATGTTCTGATCAATAATGCAGGTTGCATGGTCAATAAAAGAGAGCTCACAGAAGATGGACTTGAAAAAAA
CTTTGCTGCCAATACTCTGGGTGTGTACATTCTCACGACCGGCCTGATCCCTGTGCTGGAGAAAGAACACGACCCCCGAGTGATAACCGT
CTCCTCAGGAGGAATGTTGGTTCAGAAACTGAACACCAATGATCTCCAGTCCGAAAGAACACCATTTGATGGAACTATGGTCTATGCACA
AAACAAGAGGCAGCAAGTGGTTCTGACGGAGCGGTGGGCCCAAGGGCACCCGGCCATCCATTTTTCTTCCATGCATCCTGGCTGGGCCGA
CACCCCAGGTGTGAGGCAGGCGATGCCGGGGTTCCACGCCAGGTTCGGGGACCGCCTGCGCTCCGAGGCCCAGGGCGCGGACACCATGCT
GTGGCTGGCCCTCTCCTCTGCCGCAGCCGCACAGCCCAGCGGCCGCTTCTTTCAAGATCGGAAGCCAGTTTCTACACACTTGCCTCTCGC
TACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCAACCCAGACAC
AGTGCGGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACTTCCCCTCGAA
GACGTTGTGCCTCACAGCGAGGCCTACAAGGGATGGGAACTTTTATTTCAAAATAAATACTACCGAGGCTGTGATCAGGCTCACCTTGAA

>In-frame_ENST00000565488_ENST00000444610_TCGA-AR-A2LL_SLC25A24_chr1_108724562_-_DHRS12_chr13_52373803_length(amino acids)=481AA_start in transcript=70_stop in transcript=1515
MRAAAATPTAPQTLLRRAPRPARPRAGPGLAPQPSISRDFLGQAACASGTMLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVD
IGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELI
LQRSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEIIRESGNQNIFLHIVDLSDPKQI
WKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFD
GTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQDRKPV

--------------------------------------------------------------
>In-frame_ENST00000370041_ENST00000444610_TCGA-AR-A2LL_SLC25A24_chr1_108724562_-_DHRS12_chr13_52373803_length(transcript)=1630nt_BP=538nt
GAAGCCGTTAGGATGAGCCCTCTCCTTCCAGAGCTTTAACCGATGAAGGTGCATTGTGTTTGGCGCCCCTGAGGAGGATGCTGTCTTAGG
CCTCTTCCCACTGGACGTGTGTGGTGGGCAGAGATCCCGTTCGTCGGTCGCACTTCCACCCCGCTGGGGCTCACTCAGGCCGCGGAGCTG
CGAGGGAGACATCCTCGATGGACTCCCTCTACGGAGATCTCTTTTGGTACCTGGACTATAACAAGGATGGGACCTTGGACATTTTTGAGC
TTCAGGAAGGCCTGGAGGATGTAGGGGCCATTCAATCTCTAGAGGAAGCGAAGAAAATTTTTACTACTGGAGATGTCAACAAAGATGGGA
AGCTGGATTTTGAAGAATTTATGAAGTACCTTAAAGACCATGAGAAGAAAATGAAATTGGCATTTAAGAGTTTAGACAAAAATAATGATG
GAAAAATTGAGGCTTCAGAAATTGTCCAGTCTCTCCAGACACTGGGTCTGACTATTTCTGAACAACAAGCAGAGTTGATTCTTCAAAGGA
GTGGCTATGAATCTGCATGTAAAGACTTTGTCCCTCATGACTTGGAGGTCCAGATTCCTGGAAGAGTCTTTTTGGTCACTGGAGGAAACA
GCGGCATTGGCAAAGCAACTGCCCTTGAAATCGCCAAGCGAGGTGGCACAGTTCACCTGGTTTGTCGAGATCAAGCCCCAGCAGAAGATG
CCAGGGGTGAGATCATCCGGGAGAGCGGTAACCAGAACATTTTTCTGCACATTGTGGACTTGTCTGATCCCAAGCAAATCTGGAAATTTG
TTGAAAATTTCAAGCAGGAACATAAACTCCATGTTCTGATCAATAATGCAGGTTGCATGGTCAATAAAAGAGAGCTCACAGAAGATGGAC
TTGAAAAAAACTTTGCTGCCAATACTCTGGGTGTGTACATTCTCACGACCGGCCTGATCCCTGTGCTGGAGAAAGAACACGACCCCCGAG
TGATAACCGTCTCCTCAGGAGGAATGTTGGTTCAGAAACTGAACACCAATGATCTCCAGTCCGAAAGAACACCATTTGATGGAACTATGG
TCTATGCACAAAACAAGAGGCAGCAAGTGGTTCTGACGGAGCGGTGGGCCCAAGGGCACCCGGCCATCCATTTTTCTTCCATGCATCCTG
GCTGGGCCGACACCCCAGGTGTGAGGCAGGCGATGCCGGGGTTCCACGCCAGGTTCGGGGACCGCCTGCGCTCCGAGGCCCAGGGCGCGG
ACACCATGCTGTGGCTGGCCCTCTCCTCTGCCGCAGCCGCACAGCCCAGCGGCCGCTTCTTTCAAGATCGGAAGCCAGTTTCTACACACT
TGCCTCTCGCTACAGCGTCCTCCTCACCGGCCGAAGAGGAGAAACTCATTGAAATCCTGGAACAGCTGGCTCAGACATTTAAATAGGCCA
ACCCAGACACAGTGCGGTACCAGAATTGCCTTAGAAGATACCAGAAGGTGCGGTCTAGGGACCAGTGAATAAGAAGACCCCACTTCAACT
TCCCCTCGAAGACGTTGTGCCTCACAGCGAGGCCTACAAGGGATGGGAACTTTTATTTCAAAATAAATACTACCGAGGCTGTGATCAGGC

>In-frame_ENST00000370041_ENST00000444610_TCGA-AR-A2LL_SLC25A24_chr1_108724562_-_DHRS12_chr13_52373803_length(amino acids)=412AA_start in transcript=197_stop in transcript=1435
MDSLYGDLFWYLDYNKDGTLDIFELQEGLEDVGAIQSLEEAKKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEAS
EIVQSLQTLGLTISEQQAELILQRSGYESACKDFVPHDLEVQIPGRVFLVTGGNSGIGKATALEIAKRGGTVHLVCRDQAPAEDARGEII
RESGNQNIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSS
GGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC25A24-DHRS12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A24-DHRS12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A24-DHRS12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A24C2676780Progeroid Syndrome, Congenital, Petty Type2GENOMICS_ENGLAND;UNIPROT
HgeneSLC25A24C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC25A24C0345382Gorlin Chaudhry Moss syndrome1ORPHANET
HgeneSLC25A24C2931653Petty Laxova Wiedemann syndrome1ORPHANET