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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC35F5-ACTR3 (FusionGDB2 ID:82444)

Fusion Gene Summary for SLC35F5-ACTR3

Fusion gene summary

Fusion gene information	Fusion gene name: SLC35F5-ACTR3
	Fusion gene ID: 82444
		Hgene	Tgene
	Gene symbol	SLC35F5	ACTR3
	Gene ID	80255	10096
	Gene name	solute carrier family 35 member F5	actin related protein 3
	Synonyms	-	ARP3
	Cytomap	2q14.1	2q14.1
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 35 member F5HCV NS5A-transactivated protein 3hepatitis C virus NS5A-transactivated protein 3	actin-related protein 3ARP3 actin related protein 3 homologactin-like protein 3
	Modification date	20200313	20200327
	UniProtAcc	.	Q9C0K3
	Ensembl transtripts involved in fusion gene	ENST00000245680, ENST00000470204, ENST00000409342,	ENST00000263238, ENST00000536059, ENST00000535589,
Fusion gene scores	* DoF score	5 X 5 X 3=75	16 X 13 X 7=1456
	# samples	5	17
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1456*10)=-3.098403704061 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC35F5 [Title/Abstract] AND ACTR3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC35F5(114512741)-ACTR3(114697535), # samples:1
Anticipated loss of major functional domain due to fusion event.	SLC35F5-ACTR3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC35F5-ACTR3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACTR3	GO:0034314	Arp2/3 complex-mediated actin nucleation	11741539\|17220302
Tgene	ACTR3	GO:0045944	positive regulation of transcription by RNA polymerase II	17220302

Fusion gene breakpoints across SLC35F5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-6527	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+

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Fusion Gene ORF analysis for SLC35F5-ACTR3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000245680	ENST00000263238	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
Frame-shift	ENST00000245680	ENST00000536059	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
Frame-shift	ENST00000245680	ENST00000535589	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
intron-3CDS	ENST00000470204	ENST00000263238	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
intron-3CDS	ENST00000470204	ENST00000536059	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
intron-3CDS	ENST00000470204	ENST00000535589	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
In-frame	ENST00000409342	ENST00000263238	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
In-frame	ENST00000409342	ENST00000536059	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+
In-frame	ENST00000409342	ENST00000535589	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000409342	SLC35F5	chr2	114512741	-	ENST00000263238	ACTR3	chr2	114697535	+	6857	999	732	1715	327
ENST00000409342	SLC35F5	chr2	114512741	-	ENST00000536059	ACTR3	chr2	114697535	+	1831	999	732	1715	327
ENST00000409342	SLC35F5	chr2	114512741	-	ENST00000535589	ACTR3	chr2	114697535	+	1852	999	732	1715	327

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409342	ENST00000263238	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+	4.94E-05	0.99995065
ENST00000409342	ENST00000536059	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+	0.000430381	0.9995696
ENST00000409342	ENST00000535589	SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+	0.000410823	0.99958915

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Fusion Genomic Features for SLC35F5-ACTR3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+	1.64E-09	1
SLC35F5	chr2	114512741	-	ACTR3	chr2	114697535	+	1.64E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC35F5-ACTR3

Go to
FGviewer for the breakpoints of chr2:114512741-chr2:114697535
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTR3 Q9C0K3
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells. {ECO:0000269\|PubMed:11162478}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

69_89

91.0

1176.3333333333333

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

371_374

91.0

1176.3333333333333

Compositional bias

Note=Poly-Leu

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

252_316

91.0

1176.3333333333333

Domain

Note=EamA

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

101_121

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

243_263

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

268_288

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

296_316

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

327_347

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

361_381

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

395_415

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

420_440

91.0

1176.3333333333333

Transmembrane

Helical

Hgene

SLC35F5

chr2:114512741

chr2:114697535

ENST00000245680

452_472

91.0

1176.3333333333333

Transmembrane

Helical

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Fusion Gene Sequence for SLC35F5-ACTR3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000409342_ENST00000263238_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(transcript)=6857nt_BP=999nt
ATAGCTGACTGTGCCGTCCCTTCCCCTCACCCGCTCCACGCCCTCCTGGGCCGAGTGGAGTTGGGTGGTGTCGGGAGCCTCTCCCTGAGG
GGCACCGCGTCTTCAGGAGCTGGGCCTCCAGTGCGGCGCGATGTCAGGCGCGGTGACAGCTCTGTGAGTCCGAGGCCGCGGCCGTGGCGC
TGGGCGGCTGCGGGGCCTGACCGGTCCGCTCATGGTGCCGCCACGACGCCATCGCGGGGCAGGAAGGCCAGGTAGGCAGGCAGGGAAGGG
CCCCGACATCACCGGAGCCCAAACCGGGACGGAGTGCCCACCAGCAGCACCACCTCCTGCCCTCGGTGGCAGCAGGAGCGCCTTGACCGA
AACCGTGAAGGTCTCTAGGGGCGGAGGGAGCGGGAGCTGACAGGGGCGCCGGAGCCCTGCGCCCACCGCTGGCAATTGAGGAAGCCGTGC
GTGCGCCCTCGCCTCGGCTCCCCGGGGAGGCGTCGCTGCCTTAACTGTCTTCCCCGCTCCAAAACAGAAGGATGATTTCTTTTCCCAGCT
GTTTCTTTTAAAATGACTGGATGTTTTGATAGAGGTGGGTGGAGGAGCATGGAGAATCCTTTTCTTTTACCACTTGAAGAGATTGGAAAG
GTGCCTTCAAGACCCACAGCAAATCACTTACTCTCCGATAACCAAATTCCACTCCAGCAGATCAGGGACAGAAAAGACACTTTTAGAAAC
AGTGTCTAGACGCTGTCCCCAGGGATGGATTCCTCTGGATGGAGAGGGGTGCTGAGTTCTTCACCTCCTTTTAGACTGAGATCTGCCAAG
TTTTCCGGCATTGCTCTTGAGGATCTCAGAAGGGCTCTTAAGACAAGACTGCAAATGGTGTGTGTATTTGTCATGAACCGAATGAATTCC
CAGAACAGTGGTTTCACTCAGCGCAGGCGAATGGCTCTTGGGATTGTTATTCTTCTGCTTGTTGATGTGATATGGGTTGCTTCCTCTGAA
CTTACTTCGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTG
CTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGAT
TTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTT
TCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCAGAGTTTGCTAATCCAGACTTTACACAACCTATCTCA
GAAGTTGTAGATGAAGTAATTCAGAATTGTCCTATTGATGTCAGACGTCCTCTCTACAAGAATATTGTCCTCTCTGGAGGTTCAACCATG
TTCAGGGACTTTGGACGTCGCTTGCAAAGAGATTTGAAAAGAACTGTAGATGCCCGGCTGAAATTAAGTGAGGAATTGAGTGGTGGTAGA
TTGAAGCCAAAACCTATTGATGTACAAGTCATTACACACCACATGCAGCGATATGCAGTTTGGTTTGGAGGATCAATGCTGGCTTCCACG
CCTGAGTTCTACCAAGTATGCCACACCAAAAAGGATTATGAAGAAATTGGACCTAGCATTTGTCGTCACAATCCAGTGTTTGGAGTCATG
TCGTAAAATTGGCTTCATAGTTATTGGGGTTAGGGAGGTGGGGAAGAGATAATCTTTCTGATTACCTGTTTTGTCTGGATGGCTGGTTTT
GAGGTTTTAAACCTGACTTGAAATAGTAACACCAAACATGATTATACAGGAATATTTTAATAAGTGTATCACCATGCAGATGTAGAAGAG
AGCGAAAGTGATTGTGTTTTTCTTTAGATTGAATATTTGAATCTTATGTGTAACAAAAAGAAGTGGGTTTTAGTTCTTTCTGTGCCCTGA
TATTTTGTATATTAATGAATTATCCAAGATTCGATGGGATTTATCAGTGTGTAGATAGCTCTATAATGCTTGAATTGTACACTTCTAAGT
GTGCAGTGCAAGAGCTTGTTTATATTTCATACTTTTTATACTTTGAGGAAAAAAAGTCAAAGAAAAATTGTATTTGAGGGAAAAAACCAT
GACCAAGTAAAGGATAAATTCAAAAAATAGCCTCATGAGACTTGGCATACACACTCGTGGGATTCCAGTTATTATGGAGTGCTTCCATCC
CTCTCCACCCCTTCCCCCCAAAAGGTTTTCTTTGCAAGTGCTTTTGGAACTAAGAGCTAGTATCTTGGATTAACTGATGCCTGCTAGTGC
TTTCTGATTACTCGCATTCTGTTTCTTGCTTTAAAAGAAGAGTAAAGACAAGAGTGTTGGACCAGTATTGCAGTTCTGTAGTGTCATTTC
TTATAAAAAACAAAACAACAACAATAATTTATCAAAATTGGCATATTTAAAGCCTAACATTCTAATAAAGGCACAAATTTCTTTTTAATA
CTTGTTTCAGCCTCTTTAATCTCTTTATAAGTTAACTAATAAATCTATTTTCTTCAGACTTCTGCAATAGTTCTTTAAAATCACAACAGT
TAGCAAGCTGACTTTTGTAATGTGCTCAATACAAATACTTGTGAACTTTTAATATGTTGAGTGCTTTCATTTTGATAACTGGATCTCCAT
TTGATATTTTCATTTGTATAACTCATTTGCAGTCTGAAAATTTTTTTTAGTGCCAGTCCCTGAACATATCATTGAAAGTTAATTTTCTTT
GCATTTTAAAATATCTGGATTATGAAGAAAAAGTGATGAAAATAAATTAAAACTGAATTACCTTTTCTAATGTTTTTTTTTTTTAAGTAA
TGTAATTCTATTTTGTTTTTATGTATGTGATATCTGTTTCTGTTGAGATTTGGGAGTTATTGAAATCTCTGTAATGTGTATGGTAGAAAA
TTTCTTGTGACCTTAAAATTTTACCAGTTATTTATAGAAAGAGAAAATGGGAAATGTTTTATAGGCTTTTTACTAGCAGTATCAGTGAAC
ACTTGAACTCCATTATTCATGAAAATAACACGTTAGGATTGGAATACGTCTATTCAAAAGTGAAAGAATATAAAGTGTTTAGTTTTTTGT
TTTTACTCTAAAGATAGAATTGGGGAGTAAACTTCAGTTTTTGTTTAGAGTGGATCTGAATATTTAAAATCCTATAATAATTTTTGTGAA
TCTTCATTCTTTGAGTATGGGATTGTAAAAGACAAACTATATCCTACAGTAGTATCATCATCAGTATCAAAGGTCTCCTTTTTTTACTTG
GAAAAGTAATTCACAAACATTATAAAAATACTATTCAAACAGTACCAAAGAGTAGATTAGCAAAAGTAAGTTTTTTTCCCTAGCCTGTCT
CATTTTTCCATCATTACACAGACTACTTGGAATGTCTTAGATGTCCTTGTATTGTAATTTTCTGTGTAGGTAGAAATAAATGTAGCTTTC
TTATTTTACACAAATAGGAACTTACTGTATATACTGTTCTGCACTTTGCTTTTATTAAAGATCTTTTGATAAAGAACTATATTGATAAGC
AGTAAAGATGTCATGCTCCTGGCCCAATAAAATATTGTTAGCATTGTCATAAATATGTCTTTTCCACCGGCGATGGTTGGGTAGTTAAGT
GAATAAGCTAGAAAGACATGTTTATAAAGCTATTTGATGACAATCTCAGGCATATTTATACAGAGATGTTCTTAACTGTTTGCTACAAAA
ACATGAAGATCAAAAACTTTCTTGAAGCTTACGCTTAACTTATTTGGGGAAACAAAACTCCAGCCCTTCTTGTGTATGTTCTGATATCCC
TTTGCTCTACTTTTAGAGGAGTGAACCCTAATAGGATGGTAGCAGCATTCTTGTTTCTTTATATCTCTCCTCTGTGATTGTATACCGTTT
TTTCAACTTAAAGCAACTTCAGCTGGAAATATGTAGAGGTTGGCCAAGGTGAACTAAATAGTCTGTAACATTGATTAGATATCAAGCAAC
GTGAGCATGGTAGCAAAAGCACTAACTGAAGCCAGTGATTTAATTTTTAATTCTGATTCTGATAATTGATGATATAGCTCCTCGAACTTT
GTTTTTTGTTAAAACTTGGAAAATATATTTGTATTATTTTGGACAAATTATTTGAACTCTCTGGACCTTGATTCAATTTATATATAAGGT
AAAGGCATTATACTGGATTATCCTGCAATTTCTTTGAGTTGTTAGAATATAATGTAGCTTATTAATAGCAATATTAGCAGTGTAGTAGAT
TCTGACTGCAAAACCTAGCCTTTTCTATTGATTCATTAGTGGTAGTAAAGGTATTATCTGATTTATCCTTTTTAATAGGCAGTGCTTTGA
TCAAGTGGGAAATAGTAATGGACAAATAAAATCAATGATCATTATCTAACTTGATGCCTGCTTTTCAAAAAGTGAGCAAATTTCACATCT
TCACCCTTAGACATTAATTCATGGCACCTACTATAAGTACTCATCCTCTTCTTACCTATCTTCTTTTCTATAGGAGATAAAGTGGTTATT
CAGACCCCCCAATACAATTTTTTGGTTTGTTTTCACAGCTACTTAAAAGATTAAAATAACTATTCTTGCAGATATTTCTAGGAATATTTT
TAGAAATAATATGAAATACAGGGATAATAGGCCAATTATGATCTTTATTTTTAATTTCTACAGAAAAGTACTAGAGAATATATCTATAGA
AACTTCTTTCAGATAACCCTAAAGATGATACTAGAATGTTTATAAAATTATTGAGAAGATTATTTGTGTTATAAAGCTTATTTGTACCAT
AGTAAAGGATGTTTTTGTTCCTCTTCATTCTGGGCTAATCTGTCAATACTGAAGTCCAGTCTTTTCCCCCTTTTCTTACCAGCTCAACCT
TGATTCCTGTGACCCATTCTTTCTGATCTTTCGTAGTTCATAGTCACCAGGCATGAGTACCTTGGATAGCCCTCTGAAGTCTGTTACCAC
CCAGATTTCCAACTCGGGTTAATTGGTACTAATTCTATTAGCTGGTATAAATAATCCAAAATCTGTGCAGACTCTGGGAGCAAAATGTTC
TACTCAGTTTGGAATACTGTGCCTTAAAATATATTTCATTGTAACAGCACCTTGTATATATAGTTGGCCAAGGACAGAGTTGTTACAAGT
TACGTGGAACTTTCATAGCAAATCTTGACAGTAAATACCTTGTTCTTGTATTAGGTCTATATCCTGAATTGACCTTTAGCAAGAATCTTT
AGATCTGCTGGAGGGCTGGGATGGCTTTTGGACTTCAGTGAAAAAGAATTTCTGCTACTCATTGTTGATAACGCTTCAGTACTGTATAAA
TGTTTATCCTTTTCCACGTAATTTGTTTTCTATGATATGAGAACTTTTATTATAATTTGCCTCAGTCTTGATAGAATCTTAACAAAAATA
AAATCTGTGGTCGTCTGAGGTATTCTCCATGCTATAACCCAGTTTAGCTGATGCATTTGGAGCTTGGGTGCTGAAATTAAATATAACCTA
TTTGAGTTAAGGATTTATTACTAGTGCTCCAGTGGTCACAGGAACAATAAAAAAGGAACAACGATAGAAATACGTGATCTAGGAAAGAAG
GCAACTGAAAAACCTGAAAGAAAAAAAATGAAAGATTAAAAGTATACGATATTCTATTTTGATTTAGCAATTACTTGTTTTCTAGTGTTC
TGTCAATTTTTGGTGACTTTTATAATTACATTAAAACTAAGATGCTGAATTAAAATAAAGTTTCTCTTTTATTCAAGCACCAACATTCAC
TTATATTACCTATATATTGCATCAAGTTTTGAGCCTTCAATCCCAGAAGCATTGATTGACTGTCTACTGTGGTTCAAGTACTGTGCATAA
AGATGAATAAATATTCTGTCCTTGGCTTAGTCTAATAGTAAAGGCACTCTTAGAGGAGGGACAAATATTTTGCCTAGATAAGATTTGAGA
GATAGTAAGTGCGGAATTTCTCTTCATAAAAATGGTAGTGTTAGTTGTTTAGAGGGAGAAGTCCAGCTATGTAAGGTGAAAGTGGGGCTT
ATAAAAGTGGATCTATTGTTTAAAAATTAGTACTTTGCTCCTAAAATTTTTACCTAAGTGTTACATCCAACAACAGATGAAAGTAATTCG
ACAGTAGCATCTGCTTTATTCATTTCATATTTCCAGTGCCTGACATATTGCTTGGCATATAGTAGTTTAGTGGATGTGTTTGATGAATGA
ATGAGTAAAAATTATTTTTCATGTTAAAATAAAACTTTGAATTACATGAGTATACAACTTTTGTTCCTTCAAAATACCCATATTTGTCAA
ATATGACCGAATTACGACTTTTTTTCTGTTCCACTAGTTTCTACCTTAGAAGTGACATTCTGCGTAAGGTAGTGGGGGATTACTAAGTGA
TCATGACTTTTCTGAAGCAGGTCTTAAATAATTATCTAAGCCTTCAGTCATTTCAAAATCTCTGTAGTGTAAATGATCACAGGCTCTAAA
TCAGATTGTTGTACAAGGTAATTGACATGTCCTGAAATGTAACATTCAACATTAACAGTAGAAACAGGCCTCATTTCTCCCTCTGGCTTT
TATTGATCAATTTTGATATTGTCCAGATCCCATGTTAAACCACTTGATTTAGAGATGACTTAATTCTAAACTTCCTCCATTTTTAATTAA
TAAGATTCAAGGTTGCAGTAAATTGTTAATCTTATTTGGAATTATATTAGAAAGTCGATATCGGAATTGGAACCACACATCTTTTTCTTA

>In-frame_ENST00000409342_ENST00000263238_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(amino acids)=327AA_start in transcript=732_stop in transcript=1715
MSPGMDSSGWRGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQNSGFTQRRRMALGIVILLLVDVIWVASSELTSA
EGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDV
GYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPK

--------------------------------------------------------------
>In-frame_ENST00000409342_ENST00000536059_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(transcript)=1831nt_BP=999nt
ATAGCTGACTGTGCCGTCCCTTCCCCTCACCCGCTCCACGCCCTCCTGGGCCGAGTGGAGTTGGGTGGTGTCGGGAGCCTCTCCCTGAGG
GGCACCGCGTCTTCAGGAGCTGGGCCTCCAGTGCGGCGCGATGTCAGGCGCGGTGACAGCTCTGTGAGTCCGAGGCCGCGGCCGTGGCGC
TGGGCGGCTGCGGGGCCTGACCGGTCCGCTCATGGTGCCGCCACGACGCCATCGCGGGGCAGGAAGGCCAGGTAGGCAGGCAGGGAAGGG
CCCCGACATCACCGGAGCCCAAACCGGGACGGAGTGCCCACCAGCAGCACCACCTCCTGCCCTCGGTGGCAGCAGGAGCGCCTTGACCGA
AACCGTGAAGGTCTCTAGGGGCGGAGGGAGCGGGAGCTGACAGGGGCGCCGGAGCCCTGCGCCCACCGCTGGCAATTGAGGAAGCCGTGC
GTGCGCCCTCGCCTCGGCTCCCCGGGGAGGCGTCGCTGCCTTAACTGTCTTCCCCGCTCCAAAACAGAAGGATGATTTCTTTTCCCAGCT
GTTTCTTTTAAAATGACTGGATGTTTTGATAGAGGTGGGTGGAGGAGCATGGAGAATCCTTTTCTTTTACCACTTGAAGAGATTGGAAAG
GTGCCTTCAAGACCCACAGCAAATCACTTACTCTCCGATAACCAAATTCCACTCCAGCAGATCAGGGACAGAAAAGACACTTTTAGAAAC
AGTGTCTAGACGCTGTCCCCAGGGATGGATTCCTCTGGATGGAGAGGGGTGCTGAGTTCTTCACCTCCTTTTAGACTGAGATCTGCCAAG
TTTTCCGGCATTGCTCTTGAGGATCTCAGAAGGGCTCTTAAGACAAGACTGCAAATGGTGTGTGTATTTGTCATGAACCGAATGAATTCC
CAGAACAGTGGTTTCACTCAGCGCAGGCGAATGGCTCTTGGGATTGTTATTCTTCTGCTTGTTGATGTGATATGGGTTGCTTCCTCTGAA
CTTACTTCGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTG
CTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGAT
TTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTT
TCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCAGAGTTTGCTAATCCAGACTTTACACAACCTATCTCA
GAAGTTGTAGATGAAGTAATTCAGAATTGTCCTATTGATGTCAGACGTCCTCTCTACAAGAATATTGTCCTCTCTGGAGGTTCAACCATG
TTCAGGGACTTTGGACGTCGCTTGCAAAGAGATTTGAAAAGAACTGTAGATGCCCGGCTGAAATTAAGTGAGGAATTGAGTGGTGGTAGA
TTGAAGCCAAAACCTATTGATGTACAAGTCATTACACACCACATGCAGCGATATGCAGTTTGGTTTGGAGGATCAATGCTGGCTTCCACG
CCTGAGTTCTACCAAGTATGCCACACCAAAAAGGATTATGAAGAAATTGGACCTAGCATTTGTCGTCACAATCCAGTGTTTGGAGTCATG
TCGTAAAATTGGCTTCATAGTTATTGGGGTTAGGGAGGTGGGGAAGAGATAATCTTTCTGATTACCTGTTTTGTCTGGATGGCTGGTTTT

>In-frame_ENST00000409342_ENST00000536059_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(amino acids)=327AA_start in transcript=732_stop in transcript=1715
MSPGMDSSGWRGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQNSGFTQRRRMALGIVILLLVDVIWVASSELTSA
EGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDV
GYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPK

--------------------------------------------------------------
>In-frame_ENST00000409342_ENST00000535589_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(transcript)=1852nt_BP=999nt
ATAGCTGACTGTGCCGTCCCTTCCCCTCACCCGCTCCACGCCCTCCTGGGCCGAGTGGAGTTGGGTGGTGTCGGGAGCCTCTCCCTGAGG
GGCACCGCGTCTTCAGGAGCTGGGCCTCCAGTGCGGCGCGATGTCAGGCGCGGTGACAGCTCTGTGAGTCCGAGGCCGCGGCCGTGGCGC
TGGGCGGCTGCGGGGCCTGACCGGTCCGCTCATGGTGCCGCCACGACGCCATCGCGGGGCAGGAAGGCCAGGTAGGCAGGCAGGGAAGGG
CCCCGACATCACCGGAGCCCAAACCGGGACGGAGTGCCCACCAGCAGCACCACCTCCTGCCCTCGGTGGCAGCAGGAGCGCCTTGACCGA
AACCGTGAAGGTCTCTAGGGGCGGAGGGAGCGGGAGCTGACAGGGGCGCCGGAGCCCTGCGCCCACCGCTGGCAATTGAGGAAGCCGTGC
GTGCGCCCTCGCCTCGGCTCCCCGGGGAGGCGTCGCTGCCTTAACTGTCTTCCCCGCTCCAAAACAGAAGGATGATTTCTTTTCCCAGCT
GTTTCTTTTAAAATGACTGGATGTTTTGATAGAGGTGGGTGGAGGAGCATGGAGAATCCTTTTCTTTTACCACTTGAAGAGATTGGAAAG
GTGCCTTCAAGACCCACAGCAAATCACTTACTCTCCGATAACCAAATTCCACTCCAGCAGATCAGGGACAGAAAAGACACTTTTAGAAAC
AGTGTCTAGACGCTGTCCCCAGGGATGGATTCCTCTGGATGGAGAGGGGTGCTGAGTTCTTCACCTCCTTTTAGACTGAGATCTGCCAAG
TTTTCCGGCATTGCTCTTGAGGATCTCAGAAGGGCTCTTAAGACAAGACTGCAAATGGTGTGTGTATTTGTCATGAACCGAATGAATTCC
CAGAACAGTGGTTTCACTCAGCGCAGGCGAATGGCTCTTGGGATTGTTATTCTTCTGCTTGTTGATGTGATATGGGTTGCTTCCTCTGAA
CTTACTTCGGCTGAAGGGTATGTGATTGGCAGCTGTATTAAACACATTCCAATCGCAGGACGAGATATAACATATTTTATTCAGCAACTG
CTGAGAGACCGAGAAGTAGGAATCCCTCCAGAACAATCCTTGGAAACTGCTAAGGCAGTAAAGGAGCGCTATAGTTATGTCTGCCCAGAT
TTAGTAAAAGAATTTAACAAGTATGATACAGATGGGTCAAAATGGATTAAACAGTATACTGGAATCAATGCTATCTCAAAGAAAGAGTTT
TCTATCGATGTTGGTTATGAGAGATTTTTGGGACCTGAAATCTTTTTTCATCCAGAGTTTGCTAATCCAGACTTTACACAACCTATCTCA
GAAGTTGTAGATGAAGTAATTCAGAATTGTCCTATTGATGTCAGACGTCCTCTCTACAAGAATATTGTCCTCTCTGGAGGTTCAACCATG
TTCAGGGACTTTGGACGTCGCTTGCAAAGAGATTTGAAAAGAACTGTAGATGCCCGGCTGAAATTAAGTGAGGAATTGAGTGGTGGTAGA
TTGAAGCCAAAACCTATTGATGTACAAGTCATTACACACCACATGCAGCGATATGCAGTTTGGTTTGGAGGATCAATGCTGGCTTCCACG
CCTGAGTTCTACCAAGTATGCCACACCAAAAAGGATTATGAAGAAATTGGACCTAGCATTTGTCGTCACAATCCAGTGTTTGGAGTCATG
TCGTAAAATTGGCTTCATAGTTATTGGGGTTAGGGAGGTGGGGAAGAGATAATCTTTCTGATTACCTGTTTTGTCTGGATGGCTGGTTTT

>In-frame_ENST00000409342_ENST00000535589_TCGA-D7-6527_SLC35F5_chr2_114512741_-_ACTR3_chr2_114697535_length(amino acids)=327AA_start in transcript=732_stop in transcript=1715
MSPGMDSSGWRGVLSSSPPFRLRSAKFSGIALEDLRRALKTRLQMVCVFVMNRMNSQNSGFTQRRRMALGIVILLLVDVIWVASSELTSA
EGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDV
GYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC35F5-ACTR3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SLC35F5-ACTR3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC35F5-ACTR3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	ACTR3	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	ACTR3	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	ACTR3	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	ACTR3	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	ACTR3	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	ACTR3	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human