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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SLC38A10-MIS18A (FusionGDB2 ID:82504)

Fusion Gene Summary for SLC38A10-MIS18A

Fusion gene summary

Fusion gene information	Fusion gene name: SLC38A10-MIS18A
	Fusion gene ID: 82504
		Hgene	Tgene
	Gene symbol	SLC38A10	MIS18A
	Gene ID	124565	54069
	Gene name	solute carrier family 38 member 10	MIS18 kinetochore protein A
	Synonyms	PP1744	B28\|C21orf45\|C21orf46\|FASP1\|MIS18alpha\|hMis18alpha
	Cytomap	17q25.3	21q22.11
	Type of gene	protein-coding	protein-coding
	Description	putative sodium-coupled neutral amino acid transporter 10	protein Mis18-alphaFAPP1-associated protein 1MIS18 kinetochore protein homolog A
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NYP9
	Ensembl transtripts involved in fusion gene	ENST00000374759, ENST00000288439, ENST00000546352,	ENST00000290130, ENST00000486363,
Fusion gene scores	* DoF score	17 X 12 X 10=2040	4 X 3 X 3=36
	# samples	20	4
	** MAII score	log2(20/2040*10)=-3.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SLC38A10 [Title/Abstract] AND MIS18A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SLC38A10(79234038)-MIS18A(33647207), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLC38A10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MIS18A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-EQ-A4SO-01A	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-

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Fusion Gene ORF analysis for SLC38A10-MIS18A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000374759	ENST00000290130	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-
5CDS-intron	ENST00000374759	ENST00000486363	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-
In-frame	ENST00000288439	ENST00000290130	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-
5CDS-intron	ENST00000288439	ENST00000486363	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-
intron-3CDS	ENST00000546352	ENST00000290130	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-
intron-intron	ENST00000546352	ENST00000486363	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000374759	SLC38A10	chr17	79234038	-	ENST00000290130	MIS18A	chr21	33647207	-	2858	1672	312	2039	575
ENST00000288439	SLC38A10	chr17	79234038	-	ENST00000290130	MIS18A	chr21	33647207	-	2820	1634	274	2001	575

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374759	ENST00000290130	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-	0.003047625	0.9969524
ENST00000288439	ENST00000290130	SLC38A10	chr17	79234038	-	MIS18A	chr21	33647207	-	0.002965444	0.99703455

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Fusion Genomic Features for SLC38A10-MIS18A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC38A10-MIS18A

Go to
FGviewer for the breakpoints of chr17:79234038-chr21:33647207
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MIS18A Q9NYP9
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269\|PubMed:17199038}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

120_140

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

153_173

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

229_249

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

272_292

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

323_343

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

345_365

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

36_58

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

378_398

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

4_24

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000288439

84_104

429.3333333333333

781.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

120_140

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

153_173

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

229_249

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

272_292

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

323_343

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

345_365

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

36_58

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

378_398

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

4_24

429.3333333333333

1120.0

Transmembrane

Helical

Hgene

SLC38A10

chr17:79234038

chr21:33647207

ENST00000374759

84_104

429.3333333333333

1120.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MIS18A

chr17:79234038

chr21:33647207

ENST00000290130

80_178

111.33333333333333

234.0

Domain

Mis18

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Fusion Gene Sequence for SLC38A10-MIS18A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000374759_ENST00000290130_TCGA-EQ-A4SO-01A_SLC38A10_chr17_79234038_-_MIS18A_chr21_33647207_length(transcript)=2858nt_BP=1672nt
AAGTGTGAGCGCCGCGGCGGCAGCTGAGTTGGGCTGAGGTGTCCCTAGCTGGCTCTGCGGCTCTTCCGGGTCTGGGCTCGGAGATTCACA
GGCGGCCCGCGAGGCCGAGCGAGGGACGCATGGCCCTGAGGCGGCCGCAGGGCTTGGCGGGGTCCGGAGGTTGACCTCGCCCCCGCAGCC
GGCCTTCGAGGCTGCCTCCTCCAGGCAGCCTCTGGGGCCCGCGCCCGCGCCTGCTCAGGCTCCCGTGTTCAGGCTGCCCATCCCCTCCCC
ACCGGCGTCCCGGACGTTGGGACCTGTGACCGTGGCCTCGGGCTGGGCTTCCAAAGCCGGCCGCAGCCCGGCGACCCCCGAGGCCTCTCG
CCCCGGGCCCCTAGACCTCTCACTATGACCGCGGCCGCCGCCTCCAACTGGGGGCTGATCACGAACATCGTGAACAGCATCGTAGGGGTC
AGTGTCCTCACCATGCCCTTCTGCTTCAAACAGTGCGGCATCGTCCTGGGGGCGCTGCTCTTGGTCTTCTGCTCATGGATGACGCACCAG
TCGTGCATGTTCTTGGTGAAGTCGGCCAGCCTGAGCAAGCGGAGGACCTACGCCGGCCTGGCATTCCACGCCTACGGGAAGGCAGGCAAG
ATGCTGGTGGAGACCAGCATGATCGGGCTGATGCTGGGCACCTGCATCGCCTTCTACGTCGTGATCGGCGACTTGGGGTCCAACTTCTTT
GCCCGGCTGTTCGGGTTTCAGGTGGGCGGCACCTTCCGCATGTTCCTGCTGTTCGCCGTGTCGCTGTGCATCGTGCTCCCGCTCAGCCTG
CAGCGGAACATGATGGCCTCCATCCAGTCCTTCAGCGCCATGGCCCTCCTCTTCTACACCGTGTTCATGTTCGTGATCGTGCTCTCCTCT
CTCAAGCACGGCCTCTTCAGTGGGCAGTGGCTGCGGCGGGTCAGCTACGTCCGCTGGGAGGGCGTCTTCCGCTGCATCCCCATCTTCGGC
ATGTCCTTCGCCTGCCAGTCCCAGGTGCTGCCCACCTACGACAGCCTGGATGAGCCGTCAGTGAAAACCATGAGCTCCATATTTGCTTCC
TCCCTTAATGTGGTCACCACCTTCTACGTCATGGTGGGGTTTTTCGGCTACGTCAGCTTCACCGAGGCCACGGCCGGCAACGTGCTCATG
CACTTTCCCTCCAACCTGGTGACGGAGATGCTCCGTGTGGGCTTCATGATGTCAGTGGCTGTGGGCTTCCCCATGATGATCCTGCCATGC
AGGCAGGCCCTGAGCACGCTGCTGTGTGAGCAGCAGCAAAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAA
GCACTTACCCTCTCTGTGGTGTTTGGAACCATGGTTGGTGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACC
ATGGGAAGCCTCATCTGCTTCATCTGCCCGGCGCTGATCTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTC
GGCCTGGGCGTCCTGGTGGTGAGCACTGTCACCACACTGTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGC
CGGCTTGGAGAGGCCGAGGGTTTGATGAAGGTGGAGGCAGCGCGGCTCTCAGGTGTTTCCTGTAATGTTTCTGTGGATAAGGAACAGAAG
CTATCCAAACGTGAAAAGGAAAATGGTTGCGTCCTTGAGACTTTGTGCTGCGCGGGGTGCTCACTCAATCTTGGCTACGTGTACAGATGC
ACGCCCAAGAATCTTGATTACAAGAGAGACTTGTTTTGCCTCAGTGTTGAAGCCATTGAAAGTTATGTTTTAGGGTCCTCTGAAAAGCAA
ATTGTGTCAGAAGATAAAGAGCTTTTTAATCTTGAAAGCAGAGTTGAAATAGAAAAGTCTCTAACACAGATGGAAGATGTCTTGAAAGCA
TTACAAATGAAGCTGTGGGAGGCCGAATCCAAATTGTCCTTTGCCACTTGTAAAAGCTGAACTCTAGTCTGTGTCCTCCATTCTGCCCCC
GCCCTTCCTCCCCTTATTTGTTAAATGAAGCAACATAGTGAGACGTCGTCTCTACAAAAAAAAAAAGAAAAAAAAAATTAGCCAGGCATG
CGAAACGCTGAGGTGGGAGGATCAGATGAGCTTGGGAGGTTGAGGCTGCAGTGAGCCTTGGTCATGCCACTACTGTGTTCTAGTCTGGGC
AACAGAGTGAGACCTTCTCTCAAAAAAAAAACCCAAAATTGTAGAATTACTTCTATAGCTATATTTTATGATAAAGAAGTGATTGTTTCT
CAAAATCGCATTTTAAAGACGTTTTATGGTACTTGTTGGAATTGGGACTTAGGAGTTTTGATTTTGATAAGAAACTGGGATAATTTTCTG
AACTTTTTTTCCTCTGTATCACATTTATTTACTATTTTTAAAAACTTTGACATTTAACACTTGGGACAACATTTATTATAAATGATAAGA
AAAATCTTAGAGGTTTGTCTACCCACAGTGTCATGGAATCTTCTCTGAAAACTAATCCATAAAGTTCCCTGGAGAAATTGGTCAGAATGA
TCTGTCAGAACCATTTGAAAACTTGCTCAAGAGCAGTTGCTTATATATAGTAGGATTTTACTTTTTCCTGCTTATGTACTACTATATGCT
TAAAAAACCTGGAGGAATACTTACCAAAGAGGAGTAACCATCTCTGAGGGTGGGATTCTGGGGGAATTTTTGTTTTTTTCTGTTTTCTAT

>In-frame_ENST00000374759_ENST00000290130_TCGA-EQ-A4SO-01A_SLC38A10_chr17_79234038_-_MIS18A_chr21_33647207_length(amino acids)=575AA_start in transcript=312_stop in transcript=2039
MGFQSRPQPGDPRGLSPRAPRPLTMTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKR
RTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAM
ALLFYTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTTFYVMVGF
FGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGG
ILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAA
RLSGVSCNVSVDKEQKLSKREKENGCVLETLCCAGCSLNLGYVYRCTPKNLDYKRDLFCLSVEAIESYVLGSSEKQIVSEDKELFNLESR

--------------------------------------------------------------
>In-frame_ENST00000288439_ENST00000290130_TCGA-EQ-A4SO-01A_SLC38A10_chr17_79234038_-_MIS18A_chr21_33647207_length(transcript)=2820nt_BP=1634nt
GTGTCCCTAGCTGGCTCTGCGGCTCTTCCGGGTCTGGGCTCGGAGATTCACAGGCGGCCCGCGAGGCCGAGCGAGGGACGCATGGCCCTG
AGGCGGCCGCAGGGCTTGGCGGGGTCCGGAGGTTGACCTCGCCCCCGCAGCCGGCCTTCGAGGCTGCCTCCTCCAGGCAGCCTCTGGGGC
CCGCGCCCGCGCCTGCTCAGGCTCCCGTGTTCAGGCTGCCCATCCCCTCCCCACCGGCGTCCCGGACGTTGGGACCTGTGACCGTGGCCT
CGGGCTGGGCTTCCAAAGCCGGCCGCAGCCCGGCGACCCCCGAGGCCTCTCGCCCCGGGCCCCTAGACCTCTCACTATGACCGCGGCCGC
CGCCTCCAACTGGGGGCTGATCACGAACATCGTGAACAGCATCGTAGGGGTCAGTGTCCTCACCATGCCCTTCTGCTTCAAACAGTGCGG
CATCGTCCTGGGGGCGCTGCTCTTGGTCTTCTGCTCATGGATGACGCACCAGTCGTGCATGTTCTTGGTGAAGTCGGCCAGCCTGAGCAA
GCGGAGGACCTACGCCGGCCTGGCATTCCACGCCTACGGGAAGGCAGGCAAGATGCTGGTGGAGACCAGCATGATCGGGCTGATGCTGGG
CACCTGCATCGCCTTCTACGTCGTGATCGGCGACTTGGGGTCCAACTTCTTTGCCCGGCTGTTCGGGTTTCAGGTGGGCGGCACCTTCCG
CATGTTCCTGCTGTTCGCCGTGTCGCTGTGCATCGTGCTCCCGCTCAGCCTGCAGCGGAACATGATGGCCTCCATCCAGTCCTTCAGCGC
CATGGCCCTCCTCTTCTACACCGTGTTCATGTTCGTGATCGTGCTCTCCTCTCTCAAGCACGGCCTCTTCAGTGGGCAGTGGCTGCGGCG
GGTCAGCTACGTCCGCTGGGAGGGCGTCTTCCGCTGCATCCCCATCTTCGGCATGTCCTTCGCCTGCCAGTCCCAGGTGCTGCCCACCTA
CGACAGCCTGGATGAGCCGTCAGTGAAAACCATGAGCTCCATATTTGCTTCCTCCCTTAATGTGGTCACCACCTTCTACGTCATGGTGGG
GTTTTTCGGCTACGTCAGCTTCACCGAGGCCACGGCCGGCAACGTGCTCATGCACTTTCCCTCCAACCTGGTGACGGAGATGCTCCGTGT
GGGCTTCATGATGTCAGTGGCTGTGGGCTTCCCCATGATGATCCTGCCATGCAGGCAGGCCCTGAGCACGCTGCTGTGTGAGCAGCAGCA
AAAAGATGGCACCTTTGCAGCAGGGGGCTACATGCCCCCTCTCCGGTTTAAAGCACTTACCCTCTCTGTGGTGTTTGGAACCATGGTTGG
TGGCATCCTTATCCCCAACGTGGAGACCATCCTGGGCCTCACAGGAGCGACCATGGGAAGCCTCATCTGCTTCATCTGCCCGGCGCTGAT
CTACAAGAAAATCCACAAGAACGCACTTTCCTCCCAGGTGGTGCTGTGGGTCGGCCTGGGCGTCCTGGTGGTGAGCACTGTCACCACACT
GTCTGTGAGCGAGGAGGTCCCCGAGGACTTGGCAGAGGAAGCCCCTGGCGGCCGGCTTGGAGAGGCCGAGGGTTTGATGAAGGTGGAGGC
AGCGCGGCTCTCAGGTGTTTCCTGTAATGTTTCTGTGGATAAGGAACAGAAGCTATCCAAACGTGAAAAGGAAAATGGTTGCGTCCTTGA
GACTTTGTGCTGCGCGGGGTGCTCACTCAATCTTGGCTACGTGTACAGATGCACGCCCAAGAATCTTGATTACAAGAGAGACTTGTTTTG
CCTCAGTGTTGAAGCCATTGAAAGTTATGTTTTAGGGTCCTCTGAAAAGCAAATTGTGTCAGAAGATAAAGAGCTTTTTAATCTTGAAAG
CAGAGTTGAAATAGAAAAGTCTCTAACACAGATGGAAGATGTCTTGAAAGCATTACAAATGAAGCTGTGGGAGGCCGAATCCAAATTGTC
CTTTGCCACTTGTAAAAGCTGAACTCTAGTCTGTGTCCTCCATTCTGCCCCCGCCCTTCCTCCCCTTATTTGTTAAATGAAGCAACATAG
TGAGACGTCGTCTCTACAAAAAAAAAAAGAAAAAAAAAATTAGCCAGGCATGCGAAACGCTGAGGTGGGAGGATCAGATGAGCTTGGGAG
GTTGAGGCTGCAGTGAGCCTTGGTCATGCCACTACTGTGTTCTAGTCTGGGCAACAGAGTGAGACCTTCTCTCAAAAAAAAAACCCAAAA
TTGTAGAATTACTTCTATAGCTATATTTTATGATAAAGAAGTGATTGTTTCTCAAAATCGCATTTTAAAGACGTTTTATGGTACTTGTTG
GAATTGGGACTTAGGAGTTTTGATTTTGATAAGAAACTGGGATAATTTTCTGAACTTTTTTTCCTCTGTATCACATTTATTTACTATTTT
TAAAAACTTTGACATTTAACACTTGGGACAACATTTATTATAAATGATAAGAAAAATCTTAGAGGTTTGTCTACCCACAGTGTCATGGAA
TCTTCTCTGAAAACTAATCCATAAAGTTCCCTGGAGAAATTGGTCAGAATGATCTGTCAGAACCATTTGAAAACTTGCTCAAGAGCAGTT
GCTTATATATAGTAGGATTTTACTTTTTCCTGCTTATGTACTACTATATGCTTAAAAAACCTGGAGGAATACTTACCAAAGAGGAGTAAC
CATCTCTGAGGGTGGGATTCTGGGGGAATTTTTGTTTTTTTCTGTTTTCTATAATGTGAAACTTTTGTAGTATGTATTTTTCTAATTGAA

>In-frame_ENST00000288439_ENST00000290130_TCGA-EQ-A4SO-01A_SLC38A10_chr17_79234038_-_MIS18A_chr21_33647207_length(amino acids)=575AA_start in transcript=274_stop in transcript=2001
MGFQSRPQPGDPRGLSPRAPRPLTMTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLVFCSWMTHQSCMFLVKSASLSKR
RTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAM
ALLFYTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSLDEPSVKTMSSIFASSLNVVTTFYVMVGF
FGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMVGG
ILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTVTTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAA
RLSGVSCNVSVDKEQKLSKREKENGCVLETLCCAGCSLNLGYVYRCTPKNLDYKRDLFCLSVEAIESYVLGSSEKQIVSEDKELFNLESR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC38A10-MIS18A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SLC38A10-MIS18A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SLC38A10-MIS18A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source