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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC39A11-SLC6A4 (FusionGDB2 ID:82583)

Fusion Gene Summary for SLC39A11-SLC6A4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A11-SLC6A4
Fusion gene ID: 82583
HgeneTgene
Gene symbol

SLC39A11

SLC6A4

Gene ID

201266

6532

Gene namesolute carrier family 39 member 11solute carrier family 6 member 4
SynonymsC17orf26|ZIP-11|ZIP115-HTT|5-HTTLPR|5HTT|HTT|OCD1|SERT|SERT1|hSERT
Cytomap

17q24.3-q25.1

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP11Zrt- and Irt-like protein 11solute carrier family 39 (metal ion transporter), member 11sodium-dependent serotonin transporter5-hydroxytryptamine (serotonin) transporter5HT transporterNa+/Cl- dependent serotonin transporterserotonin transporter 1solute carrier family 6 (neurotransmitter transporter), member 4solute carrier family 6 (ne
Modification date2020031320200329
UniProtAcc.

P31645

Ensembl transtripts involved in fusion geneENST00000255559, ENST00000542342, 
ENST00000579988, ENST00000579732, 
ENST00000401766, ENST00000261707, 
Fusion gene scores* DoF score28 X 24 X 11=73924 X 3 X 4=48
# samples 356
** MAII scorelog2(35/7392*10)=-4.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC39A11 [Title/Abstract] AND SLC6A4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC39A11(70943891)-SLC6A4(28538442), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC39A11-SLC6A4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC39A11-SLC6A4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SLC39A11-SLC6A4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSLC6A4

GO:0009636

response to toxic substance

17575980

TgeneSLC6A4

GO:0015844

monoamine transport

16024787

TgeneSLC6A4

GO:0051610

serotonin uptake

8987735|16870614|17506858


check buttonFusion gene breakpoints across SLC39A11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC6A4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-SR-A6MP-01ASLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
ChimerDB4PCPGTCGA-SR-A6MP-01ASLC39A11chr17

70943891

-SLC6A4chr17

28538442

-


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Fusion Gene ORF analysis for SLC39A11-SLC6A4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000255559ENST00000401766SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
Frame-shiftENST00000255559ENST00000261707SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
intron-3CDSENST00000542342ENST00000401766SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
intron-3CDSENST00000542342ENST00000261707SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
intron-3CDSENST00000579988ENST00000401766SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
intron-3CDSENST00000579988ENST00000261707SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
Frame-shiftENST00000579732ENST00000401766SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-
Frame-shiftENST00000579732ENST00000261707SLC39A11chr17

70943891

-SLC6A4chr17

28538442

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC39A11-SLC6A4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC39A11-SLC6A4


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SLC6A4

P31645

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069, ECO:0000269|PubMed:19270731, ECO:0000269|PubMed:27049939}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC39A11-SLC6A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC39A11-SLC6A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC39A11-SLC6A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC6A4P31645DB00215CitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00215CitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00215CitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00245BenzatropineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00245BenzatropineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00245BenzatropineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00285VenlafaxineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00285VenlafaxineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00285VenlafaxineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00289AtomoxetineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00289AtomoxetineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00289AtomoxetineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00321AmitriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00321AmitriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00321AmitriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00344ProtriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00344ProtriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00344ProtriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00408LoxapineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00408LoxapineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00408LoxapineBinderSmall moleculeApproved
TgeneSLC6A4P31645DB00454MeperidineBindingSmall moleculeApproved
TgeneSLC6A4P31645DB00454MeperidineBindingSmall moleculeApproved
TgeneSLC6A4P31645DB00454MeperidineBindingSmall moleculeApproved
TgeneSLC6A4P31645DB00458ImipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00458ImipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00458ImipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00476DuloxetineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00476DuloxetineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00476DuloxetineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00514DextromethorphanInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00514DextromethorphanInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00514DextromethorphanInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00540NortriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00540NortriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00540NortriptylineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00543AmoxapineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00543AmoxapineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00543AmoxapineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00661VerapamilUnknownSmall moleculeApproved
TgeneSLC6A4P31645DB00661VerapamilUnknownSmall moleculeApproved
TgeneSLC6A4P31645DB00661VerapamilUnknownSmall moleculeApproved
TgeneSLC6A4P31645DB00726TrimipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00726TrimipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00726TrimipramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00805MinaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00805MinaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00805MinaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00852PseudoephedrineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00852PseudoephedrineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00852PseudoephedrineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00924CyclobenzaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00924CyclobenzaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00924CyclobenzaprineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00988DopamineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00988DopamineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB00988DopamineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01104SertralineBinder|Downregulator|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01104SertralineBinder|Downregulator|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01104SertralineBinder|Downregulator|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01114ChlorpheniramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01114ChlorpheniramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01114ChlorpheniramineInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01175EscitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01175EscitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB01175EscitalopramInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06204TapentadolInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06204TapentadolInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06204TapentadolInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06684VilazodoneInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06684VilazodoneInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB06684VilazodoneInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09016ButriptylineAntagonist|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09016ButriptylineAntagonist|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09016ButriptylineAntagonist|InhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09167DosulepinInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09167DosulepinInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09167DosulepinInhibitorSmall moleculeApproved
TgeneSLC6A4P31645DB09195LorpiprazoleAntagonistSmall moleculeApproved
TgeneSLC6A4P31645DB09195LorpiprazoleAntagonistSmall moleculeApproved
TgeneSLC6A4P31645DB09195LorpiprazoleAntagonistSmall moleculeApproved
TgeneSLC6A4P31645DB00191PhentermineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00191PhentermineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00191PhentermineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00907CocaineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00907CocaineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00907CocaineInhibitorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB01577MetamfetamineNegative modulatorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB01577MetamfetamineNegative modulatorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB01577MetamfetamineNegative modulatorSmall moleculeApproved|Illicit
TgeneSLC6A4P31645DB00182AmphetamineBinderSmall moleculeApproved|Illicit|Investigational
TgeneSLC6A4P31645DB00182AmphetamineBinderSmall moleculeApproved|Illicit|Investigational
TgeneSLC6A4P31645DB00182AmphetamineBinderSmall moleculeApproved|Illicit|Investigational
TgeneSLC6A4P31645DB00574FenfluramineInhibitor|SubstrateSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB00574FenfluramineInhibitor|SubstrateSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB00574FenfluramineInhibitor|SubstrateSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01105SibutramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01105SibutramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01105SibutramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01191DexfenfluramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01191DexfenfluramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB01191DexfenfluramineInhibitorSmall moleculeApproved|Illicit|Investigational|Withdrawn
TgeneSLC6A4P31645DB00176FluvoxamineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00176FluvoxamineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00176FluvoxamineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00193TramadolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00193TramadolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00193TramadolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00579MazindolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00579MazindolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00579MazindolInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00656TrazodoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00656TrazodoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00656TrazodoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00715ParoxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00715ParoxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB00715ParoxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01142DoxepinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01142DoxepinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01142DoxepinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01151DesipramineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01151DesipramineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01151DesipramineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01238AripiprazoleModulatorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01238AripiprazoleModulatorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01238AripiprazoleModulatorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB04896MilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB04896MilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB04896MilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06077LumateperoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06077LumateperoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06077LumateperoneInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06148MianserinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06148MianserinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06148MianserinInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06700DesvenlafaxineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06700DesvenlafaxineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06700DesvenlafaxineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06701DexmethylphenidateInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06701DexmethylphenidateInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB06701DexmethylphenidateInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB08918LevomilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB08918LevomilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB08918LevomilnacipranInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB09068VortioxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB09068VortioxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB09068VortioxetineInhibitorSmall moleculeApproved|Investigational
TgeneSLC6A4P31645DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneSLC6A4P31645DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneSLC6A4P31645DB01242ClomipramineInhibitorSmall moleculeApproved|Investigational|Vet_approved
TgeneSLC6A4P31645DB09225ZotepineAntagonistSmall moleculeApproved|Investigational|Withdrawn
TgeneSLC6A4P31645DB09225ZotepineAntagonistSmall moleculeApproved|Investigational|Withdrawn
TgeneSLC6A4P31645DB09225ZotepineAntagonistSmall moleculeApproved|Investigational|Withdrawn
TgeneSLC6A4P31645DB00472FluoxetineInhibitorSmall moleculeApproved|Vet_approved
TgeneSLC6A4P31645DB00472FluoxetineInhibitorSmall moleculeApproved|Vet_approved
TgeneSLC6A4P31645DB00472FluoxetineInhibitorSmall moleculeApproved|Vet_approved
TgeneSLC6A4P31645DB01149NefazodoneInhibitorSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB01149NefazodoneInhibitorSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB01149NefazodoneInhibitorSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04821NomifensineSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04821NomifensineSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04821NomifensineSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04832ZimelidineSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04832ZimelidineSmall moleculeApproved|Withdrawn
TgeneSLC6A4P31645DB04832ZimelidineSmall moleculeApproved|Withdrawn

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Related Diseases for SLC39A11-SLC6A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSLC6A4C0011581Depressive disorder9CTD_human;PSYGENET
TgeneSLC6A4C0025193Melancholia9CTD_human;PSYGENET
TgeneSLC6A4C0041696Unipolar Depression9CTD_human;PSYGENET
TgeneSLC6A4C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
TgeneSLC6A4C0005586Bipolar Disorder7CTD_human;PSYGENET
TgeneSLC6A4C0525045Mood Disorders6CTD_human;PSYGENET
TgeneSLC6A4C1269683Major Depressive Disorder6CTD_human;PSYGENET
TgeneSLC6A4C0004352Autistic Disorder5CTD_human
TgeneSLC6A4C0011570Mental Depression5PSYGENET
TgeneSLC6A4C0085159Seasonal Affective Disorder5PSYGENET
TgeneSLC6A4C0221074Depression, Postpartum5PSYGENET
TgeneSLC6A4C0344315Depressed mood5PSYGENET
TgeneSLC6A4C0600427Cocaine Dependence5CTD_human;PSYGENET
TgeneSLC6A4C0005587Depression, Bipolar4CTD_human;PSYGENET
TgeneSLC6A4C0011573Endogenous depression4CTD_human
TgeneSLC6A4C0085762Alcohol abuse4CTD_human;PSYGENET
TgeneSLC6A4C0086133Depressive Syndrome4CTD_human
TgeneSLC6A4C0282126Depression, Neurotic4CTD_human
TgeneSLC6A4C0581391Chronic depression4PSYGENET
TgeneSLC6A4C0221480Recurrent depression3PSYGENET
TgeneSLC6A4C0233477Dysphoric mood3PSYGENET
TgeneSLC6A4C2063866Depressive Disorder, Treatment-Resistant3PSYGENET
TgeneSLC6A4C0001723Affective Disorders, Psychotic2PSYGENET
TgeneSLC6A4C0001956Alcohol Use Disorder2CTD_human
TgeneSLC6A4C0003467Anxiety2GENOMICS_ENGLAND
TgeneSLC6A4C0024713Manic Disorder2CTD_human
TgeneSLC6A4C0025261Memory Disorders2CTD_human
TgeneSLC6A4C0028768Obsessive-Compulsive Disorder2CTD_human;GENOMICS_ENGLAND
TgeneSLC6A4C0038644Sudden infant death syndrome2CTD_human;GENOMICS_ENGLAND
TgeneSLC6A4C0178417Anhedonia2PSYGENET
TgeneSLC6A4C0233794Memory impairment2CTD_human
TgeneSLC6A4C0338715Drug-induced depressive state2PSYGENET
TgeneSLC6A4C0338831Manic2CTD_human
TgeneSLC6A4C0751292Age-Related Memory Disorders2CTD_human
TgeneSLC6A4C0751293Memory Disorder, Semantic2CTD_human
TgeneSLC6A4C0751294Memory Disorder, Spatial2CTD_human
TgeneSLC6A4C0751295Memory Loss2CTD_human
TgeneSLC6A4C0001969Alcoholic Intoxication1PSYGENET
TgeneSLC6A4C0003469Anxiety Disorders1CTD_human
TgeneSLC6A4C0003944As If Personality1CTD_human
TgeneSLC6A4C0004444Avoidant Personality Disorder1CTD_human
TgeneSLC6A4C0009171Cocaine Abuse1CTD_human
TgeneSLC6A4C0009241Cognition Disorders1CTD_human
TgeneSLC6A4C0011574Involutional Depression1CTD_human
TgeneSLC6A4C0013146Drug abuse1CTD_human
TgeneSLC6A4C0013170Drug habituation1CTD_human
TgeneSLC6A4C0013222Drug Use Disorders1CTD_human
TgeneSLC6A4C0013415Dysthymic Disorder1PSYGENET
TgeneSLC6A4C0020542Pulmonary Hypertension1CTD_human
TgeneSLC6A4C0021124Impulse-Ridden Personality1CTD_human
TgeneSLC6A4C0021139Inadequate Personality1CTD_human
TgeneSLC6A4C0024809Marijuana Abuse1PSYGENET
TgeneSLC6A4C0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneSLC6A4C0031212Personality Disorders1CTD_human
TgeneSLC6A4C0036341Schizophrenia1CTD_human
TgeneSLC6A4C0038580Substance Dependence1CTD_human
TgeneSLC6A4C0038586Substance Use Disorders1CTD_human
TgeneSLC6A4C0038587Substance Withdrawal Syndrome1CTD_human
TgeneSLC6A4C0086189Drug Withdrawal Symptoms1CTD_human
TgeneSLC6A4C0087169Withdrawal Symptoms1CTD_human
TgeneSLC6A4C0236733Amphetamine-Related Disorders1CTD_human
TgeneSLC6A4C0236736Cocaine-Related Disorders1CTD_human
TgeneSLC6A4C0236792Asperger Syndrome1CTD_human
TgeneSLC6A4C0236804Amphetamine Addiction1CTD_human
TgeneSLC6A4C0236807Amphetamine Abuse1CTD_human
TgeneSLC6A4C0236969Substance-Related Disorders1CTD_human
TgeneSLC6A4C0376280Anxiety States, Neurotic1CTD_human
TgeneSLC6A4C0588008Severe depression1PSYGENET
TgeneSLC6A4C0740858Substance abuse problem1CTD_human
TgeneSLC6A4C1279420Anxiety neurosis (finding)1CTD_human
TgeneSLC6A4C1510472Drug Dependence1CTD_human
TgeneSLC6A4C1571983Involutional paraphrenia1CTD_human
TgeneSLC6A4C1571984Psychosis, Involutional1CTD_human
TgeneSLC6A4C3160814Cannabis use1PSYGENET
TgeneSLC6A4C4316881Prescription Drug Abuse1CTD_human