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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC39A7-TAF6 (FusionGDB2 ID:82627)

Fusion Gene Summary for SLC39A7-TAF6

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A7-TAF6
Fusion gene ID: 82627
HgeneTgene
Gene symbol

SLC39A7

TAF6

Gene ID

7922

6878

Gene namesolute carrier family 39 member 7TATA-box binding protein associated factor 6
SynonymsD6S115E|D6S2244E|H2-KE4|HKE4|KE4|RING5|ZIP7ALYUS|MGC:8964|TAF(II)70|TAF(II)80|TAF2E|TAFII-70|TAFII-80|TAFII70|TAFII80|TAFII85
Cytomap

6p21.32

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter SLC39A7HLA class II region expressed gene KE4Ke4 gene, mouse, human homolog ofhistidine-rich membrane protein Ke4really interesting new gene 5 proteinsolute carrier family 39 (zinc transporter), member 7zrt-, Irt-like protein 7transcription initiation factor TFIID subunit 6RNA polymerase II TBP-associated factor subunit ETAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85
Modification date2020031320200313
UniProtAcc.

TAF6L

Ensembl transtripts involved in fusion geneENST00000374675, ENST00000374677, 
ENST00000463972, ENST00000423043, 
ENST00000418477, ENST00000486338, 
ENST00000416369, ENST00000441854, 
ENST00000477713, ENST00000441953, 
ENST00000431735, ENST00000462670, 
ENST00000383214, ENST00000383213, 
ENST00000486373, ENST00000443773, 
ENST00000456261, ENST00000487655, 
ENST00000453269, ENST00000472509, 
ENST00000452041, ENST00000344095, 
ENST00000418432, ENST00000437822, 
ENST00000497233, 
Fusion gene scores* DoF score5 X 4 X 4=8013 X 8 X 5=520
# samples 614
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/520*10)=-1.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A7 [Title/Abstract] AND TAF6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC39A7(33168715)-TAF6(99705246), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAF6

GO:0006352

DNA-templated transcription, initiation

9603525

TgeneTAF6

GO:0006367

transcription initiation from RNA polymerase II promoter

9603525

TgeneTAF6

GO:0045786

negative regulation of cell cycle

15328371


check buttonFusion gene breakpoints across SLC39A7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TAF6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6454SLC39A7chr6

33168715

+TAF6chr7

99705246

-


Top

Fusion Gene ORF analysis for SLC39A7-TAF6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000374675ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374675ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374675ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374675ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374675ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374675ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-intronENST00000374675ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-3CDSENST00000374677ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
5UTR-intronENST00000374677ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000463972ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000463972ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000423043ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000423043ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000418477ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000418477ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486338ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000486338ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000416369ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000416369ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441854ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000441854ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000477713ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000477713ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000441953ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000441953ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000431735ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000431735ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000462670ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000462670ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383214ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000383214ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000383213ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000383213ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000486373ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000486373ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000443773ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000443773ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000456261ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000456261ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000453269SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000472509SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000452041SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000344095SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000418432SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-3CDSENST00000487655ENST00000437822SLC39A7chr6

33168715

+TAF6chr7

99705246

-
intron-intronENST00000487655ENST00000497233SLC39A7chr6

33168715

+TAF6chr7

99705246

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SLC39A7-TAF6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC39A7-TAF6


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TAF6

TAF6L

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.622

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC39A7-TAF6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC39A7-TAF6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC39A7-TAF6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC39A7-TAF6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A7C0001768Agammaglobulinemia1GENOMICS_ENGLAND
TgeneTAF6C4310702ALAZAMI-YUAN SYNDROME2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneTAF6C3714756Intellectual Disability1GENOMICS_ENGLAND