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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC3A2-SLC3A2 (FusionGDB2 ID:82660)

Fusion Gene Summary for SLC3A2-SLC3A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC3A2-SLC3A2
Fusion gene ID: 82660
HgeneTgene
Gene symbol

SLC3A2

SLC3A2

Gene ID

6520

6520

Gene namesolute carrier family 3 member 2solute carrier family 3 member 2
Synonyms4F2|4F2HC|4T2HC|CD98|CD98HC|MDU1|NACAE4F2|4F2HC|4T2HC|CD98|CD98HC|MDU1|NACAE
Cytomap

11q12.3

11q12.3

Type of geneprotein-codingprotein-coding
Description4F2 cell-surface antigen heavy chainCD98 heavy chainantigen defined by monoclonal antibody 4F2, heavy chainantigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43lymphocyte activation antigen 4F2 large subunitmonoclonal antibody 44D74F2 cell-surface antigen heavy chainCD98 heavy chainantigen defined by monoclonal antibody 4F2, heavy chainantigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43lymphocyte activation antigen 4F2 large subunitmonoclonal antibody 44D7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377892, ENST00000377890, 
ENST00000377891, ENST00000377889, 
ENST00000535296, ENST00000338663, 
ENST00000538682, ENST00000536981, 
ENST00000377892, ENST00000377890, 
ENST00000377891, ENST00000377889, 
ENST00000535296, ENST00000338663, 
ENST00000538682, ENST00000536981, 
Fusion gene scores* DoF score15 X 12 X 9=162010 X 11 X 7=770
# samples 1913
** MAII scorelog2(19/1620*10)=-3.09192248944104
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC3A2 [Title/Abstract] AND SLC3A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC3A2(62648455)-SLC3A2(62652959), # samples:2
Anticipated loss of major functional domain due to fusion event.SLC3A2-SLC3A2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC3A2-SLC3A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC3A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC3A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF088478SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
ChiTaRS5.0N/ABG471247SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
ChiTaRS5.0N/ABG472080SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
ChiTaRS5.0N/ABQ354047SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-


Top

Fusion Gene ORF analysis for SLC3A2-SLC3A2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000377892ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377892ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377892ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377892ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377892ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377892ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000377892ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000377892ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377890ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000377890ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000377890ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377891ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000377891ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000377891ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000377889ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000377889ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000377889ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000535296ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000535296ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000535296ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3CDSENST00000338663ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-3UTRENST00000338663ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
5UTR-5UTRENST00000338663ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000538682ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000538682ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000538682ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000377892SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000377890SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000377891SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000377889SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000535296SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3CDSENST00000536981ENST00000338663SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-3UTRENST00000536981ENST00000538682SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
intron-5UTRENST00000536981ENST00000536981SLC3A2chr11

62648455

-SLC3A2chr11

62652959

-
Frame-shiftENST00000377892ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377892ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377892ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377890ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377890ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377890ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377891ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377891ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377891ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377889ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377889ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000377889ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000535296ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000535296ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000535296ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
In-frameENST00000338663ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000338663ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000338663ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3CDSENST00000538682ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3UTRENST00000538682ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
intron-3UTRENST00000538682ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000377892SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000377890SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000377891SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000377889SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000535296SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000536981ENST00000338663SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000536981ENST00000538682SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
5CDS-3UTRENST00000536981ENST00000536981SLC3A2chr11

62656079

+SLC3A2chr11

62655606

+
Frame-shiftENST00000377892ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377892ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377892ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377892ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377892ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377892ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000377892ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000377892ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377890ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000377890ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000377890ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000377891ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000377891ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000377891ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000377889ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000377889ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000377889ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000535296ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000535296ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000535296ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000338663ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000338663ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000338663ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
Frame-shiftENST00000538682ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000538682ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000538682ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000377892SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000377890SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000377891SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000377889SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000535296SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
In-frameENST00000536981ENST00000338663SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-3UTRENST00000536981ENST00000538682SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+
5CDS-5UTRENST00000536981ENST00000536981SLC3A2chr11

62655929

+SLC3A2chr11

62652670

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC3A2-SLC3A2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC3A2-SLC3A2


check button Go to

FGviewer for the breakpoints of chr11:62656079-chr11:62655606

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC3A2chr11:62655929chr11:62652670ENST0000033866309102_1840530.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62655929chr11:62652670ENST0000033866309206_6300530.0Topological domainExtracellular
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889010102_1840569.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889010206_6300569.0Topological domainExtracellular
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890012102_1840631.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890012206_6300631.0Topological domainExtracellular
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892013102_1840662.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892013206_6300662.0Topological domainExtracellular
TgeneSLC3A2chr11:62655929chr11:62652670ENST0000033866309185_2050530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889010185_2050569.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890012185_2050631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892013185_2050662.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000338663+19102_1840530.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000338663+19206_6300530.0Topological domainExtracellular
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889+110102_1840569.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889+110206_6300569.0Topological domainExtracellular
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890+112102_1840631.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890+112206_6300631.0Topological domainExtracellular
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892+113102_1840662.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892+113206_6300662.0Topological domainExtracellular
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000338663+19102_1840530.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000338663+19206_6300530.0Topological domainExtracellular
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889+110102_1840569.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889+110206_6300569.0Topological domainExtracellular
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890+112102_1840631.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890+112206_6300631.0Topological domainExtracellular
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377892+113102_1840662.0Topological domainCytoplasmic
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377892+113206_6300662.0Topological domainExtracellular
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000338663+19185_2050530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377889+110185_2050569.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377890+112185_2050631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62655929chr11:62652670ENST00000377892+113185_2050662.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000338663+19185_2050530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889+110185_2050569.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890+112185_2050631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneSLC3A2chr11:62656079chr11:62655606ENST00000377892+113185_2050662.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62656079chr11:62655606ENST0000033866369102_184381.0530.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62656079chr11:62655606ENST0000033866369206_630381.0530.0Topological domainExtracellular
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889710102_184420.0569.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889710206_630420.0569.0Topological domainExtracellular
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890912102_184482.0631.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890912206_630482.0631.0Topological domainExtracellular
TgeneSLC3A2chr11:62656079chr11:62655606ENST000003778921013102_184513.0662.0Topological domainCytoplasmic
TgeneSLC3A2chr11:62656079chr11:62655606ENST000003778921013206_630513.0662.0Topological domainExtracellular
TgeneSLC3A2chr11:62656079chr11:62655606ENST0000033866369185_205381.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377889710185_205420.0569.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62656079chr11:62655606ENST00000377890912185_205482.0631.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneSLC3A2chr11:62656079chr11:62655606ENST000003778921013185_205513.0662.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for SLC3A2-SLC3A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC3A2-SLC3A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC3A2-SLC3A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC3A2-SLC3A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC3A2C0024121Lung Neoplasms1CTD_human
HgeneSLC3A2C0242379Malignant neoplasm of lung1CTD_human
TgeneSLC3A2C0024121Lung Neoplasms1CTD_human
TgeneSLC3A2C0242379Malignant neoplasm of lung1CTD_human