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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC41A2-DNM3 (FusionGDB2 ID:82668)

Fusion Gene Summary for SLC41A2-DNM3

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC41A2-DNM3
Fusion gene ID: 82668
HgeneTgene
Gene symbol

SLC41A2

DNM3

Gene ID

84102

26052

Gene namesolute carrier family 41 member 2dynamin 3
SynonymsSLC41A1-L1Dyna III
Cytomap

12q23.3

1q24.3

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 41 member 2SLC41A1-like 1solute carrier family 41 (magnesium transporter), member 2dynamin-3T-dynamindynamin family memberdynamin, testicular
Modification date2020031320200313
UniProtAcc.

Q9UQ16

Ensembl transtripts involved in fusion geneENST00000258538, ENST00000549713, 
ENST00000358155, ENST00000367733, 
ENST00000355305, ENST00000367731, 
ENST00000520906, 
Fusion gene scores* DoF score4 X 4 X 3=4819 X 17 X 5=1615
# samples 521
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/1615*10)=-2.94307293191516
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC41A2 [Title/Abstract] AND DNM3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC41A2(105280070)-DNM3(172100314), # samples:1
SLC41A2(105280071)-DNM3(172100315), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC41A2-DNM3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLC41A2-DNM3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC41A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DNM3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A48NSLC41A2chr12

105280070

-DNM3chr1

172100314

+
ChimerDB4SARCTCGA-DX-A48N-01ASLC41A2chr12

105280071

-DNM3chr1

172100315

+


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Fusion Gene ORF analysis for SLC41A2-DNM3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000258538ENST00000358155SLC41A2chr12

105280070

-DNM3chr1

172100314

+
Frame-shiftENST00000258538ENST00000367733SLC41A2chr12

105280070

-DNM3chr1

172100314

+
Frame-shiftENST00000258538ENST00000355305SLC41A2chr12

105280070

-DNM3chr1

172100314

+
Frame-shiftENST00000258538ENST00000367731SLC41A2chr12

105280070

-DNM3chr1

172100314

+
Frame-shiftENST00000258538ENST00000520906SLC41A2chr12

105280070

-DNM3chr1

172100314

+
intron-3CDSENST00000549713ENST00000358155SLC41A2chr12

105280070

-DNM3chr1

172100314

+
intron-3CDSENST00000549713ENST00000367733SLC41A2chr12

105280070

-DNM3chr1

172100314

+
intron-3CDSENST00000549713ENST00000355305SLC41A2chr12

105280070

-DNM3chr1

172100314

+
intron-3CDSENST00000549713ENST00000367731SLC41A2chr12

105280070

-DNM3chr1

172100314

+
intron-3CDSENST00000549713ENST00000520906SLC41A2chr12

105280070

-DNM3chr1

172100314

+
Frame-shiftENST00000258538ENST00000358155SLC41A2chr12

105280071

-DNM3chr1

172100315

+
Frame-shiftENST00000258538ENST00000367733SLC41A2chr12

105280071

-DNM3chr1

172100315

+
Frame-shiftENST00000258538ENST00000355305SLC41A2chr12

105280071

-DNM3chr1

172100315

+
Frame-shiftENST00000258538ENST00000367731SLC41A2chr12

105280071

-DNM3chr1

172100315

+
Frame-shiftENST00000258538ENST00000520906SLC41A2chr12

105280071

-DNM3chr1

172100315

+
intron-3CDSENST00000549713ENST00000358155SLC41A2chr12

105280071

-DNM3chr1

172100315

+
intron-3CDSENST00000549713ENST00000367733SLC41A2chr12

105280071

-DNM3chr1

172100315

+
intron-3CDSENST00000549713ENST00000355305SLC41A2chr12

105280071

-DNM3chr1

172100315

+
intron-3CDSENST00000549713ENST00000367731SLC41A2chr12

105280071

-DNM3chr1

172100315

+
intron-3CDSENST00000549713ENST00000520906SLC41A2chr12

105280071

-DNM3chr1

172100315

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC41A2-DNM3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC41A2chr12105280070-DNM3chr1172100314+1.94E-050.99998057
SLC41A2chr12105280070-DNM3chr1172100314+1.94E-050.99998057
SLC41A2chr12105280070-DNM3chr1172100314+1.94E-050.99998057
SLC41A2chr12105280070-DNM3chr1172100314+1.94E-050.99998057

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC41A2-DNM3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DNM3

Q9UQ16

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC41A2-DNM3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC41A2-DNM3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC41A2-DNM3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC41A2-DNM3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDNM3C0022665Kidney Neoplasm1CTD_human
TgeneDNM3C0740457Malignant neoplasm of kidney1CTD_human