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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC44A5-PTGFR (FusionGDB2 ID:82730)

Fusion Gene Summary for SLC44A5-PTGFR

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC44A5-PTGFR
Fusion gene ID: 82730
HgeneTgene
Gene symbol

SLC44A5

PTGFR

Gene ID

204962

5737

Gene namesolute carrier family 44 member 5prostaglandin F receptor
SynonymsCTL5FP
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 5prostaglandin F2-alpha receptorFP prostanoid receptorPGF receptorPGF2 alpha receptorprostaglandin receptor (2-alpha)prostanoid FP receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000370859, ENST00000370855, 
ENST00000535611, ENST00000469525, 
ENST00000370758, ENST00000370756, 
ENST00000370757, 
Fusion gene scores* DoF score8 X 8 X 3=1925 X 5 X 3=75
# samples 85
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC44A5 [Title/Abstract] AND PTGFR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC44A5(75677153)-PTGFR(79002091), # samples:1
Anticipated loss of major functional domain due to fusion event.SLC44A5-PTGFR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SLC44A5-PTGFR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC44A5-PTGFR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTGFR

GO:0035584

calcium-mediated signaling using intracellular calcium source

18587449


check buttonFusion gene breakpoints across SLC44A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTGFR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Z-01ASLC44A5chr1

75677153

-PTGFRchr1

79002091

+


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Fusion Gene ORF analysis for SLC44A5-PTGFR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370859ENST00000370758SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000370859ENST00000370756SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000370859ENST00000370757SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000370855ENST00000370758SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000370855ENST00000370756SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000370855ENST00000370757SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
In-frameENST00000535611ENST00000370758SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
Frame-shiftENST00000535611ENST00000370756SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
In-frameENST00000535611ENST00000370757SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
intron-3CDSENST00000469525ENST00000370758SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
intron-3CDSENST00000469525ENST00000370756SLC44A5chr1

75677153

-PTGFRchr1

79002091

+
intron-3CDSENST00000469525ENST00000370757SLC44A5chr1

75677153

-PTGFRchr1

79002091

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535611SLC44A5chr175677153-ENST00000370758PTGFRchr179002091+530819641062016636
ENST00000535611SLC44A5chr175677153-ENST00000370757PTGFRchr179002091+530819641062016636

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535611ENST00000370758SLC44A5chr175677153-PTGFRchr179002091+0.0007144220.99928564
ENST00000535611ENST00000370757SLC44A5chr175677153-PTGFRchr179002091+0.0007144220.99928564

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Fusion Genomic Features for SLC44A5-PTGFR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC44A5chr175677152-PTGFRchr179002090+3.53E-050.9999646
SLC44A5chr175677152-PTGFRchr179002090+3.53E-050.9999646

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC44A5-PTGFR


check button Go to

FGviewer for the breakpoints of chr1:75677153-chr1:79002091

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-23241_38682.3333333333334720.0Topological domainCytoplasmic
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324264_265682.3333333333334720.0Topological domainCytoplasmic
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324287_325682.3333333333334720.0Topological domainExtracellular
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324347_351682.3333333333334720.0Topological domainCytoplasmic
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324373_374682.3333333333334720.0Topological domainExtracellular
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324396_460682.3333333333334720.0Topological domainCytoplasmic
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324482_515682.3333333333334720.0Topological domainExtracellular
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324537_610682.3333333333334720.0Topological domainCytoplasmic
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-232460_242682.3333333333334720.0Topological domainExtracellular
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324632_649682.3333333333334720.0Topological domainExtracellular
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324243_263682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324266_286682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324326_346682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324352_372682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324375_395682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-232439_59682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324461_481682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324516_536682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324611_631682.3333333333334720.0TransmembraneHelical
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324650_670682.3333333333334720.0TransmembraneHelical
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624308_359289.6666666666667298.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713268_285266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713308_359266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824268_285266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824308_359266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713286_307266.0360.0TransmembraneHelical%3B Name%3D7
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824286_307266.0360.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A5chr1:75677153chr1:79002091ENST00000370855-2324671_719682.3333333333334720.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624132_152289.6666666666667298.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624176_198289.6666666666667298.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST00000370756241_31289.6666666666667298.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624225_250289.6666666666667298.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624268_285289.6666666666667298.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST000003707562455_69289.6666666666667298.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST000003707562491_109289.6666666666667298.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713132_152266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713176_198266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST00000370757131_31266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713225_250266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST000003707571355_69266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST000003707571391_109266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824132_152266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824176_198266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST00000370758241_31266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824225_250266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST000003707582455_69266.0360.0Topological domainCytoplasmic
TgenePTGFRchr1:75677153chr1:79002091ENST000003707582491_109266.0360.0Topological domainExtracellular
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624110_131289.6666666666667298.0TransmembraneHelical%3B Name%3D3
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624153_175289.6666666666667298.0TransmembraneHelical%3B Name%3D4
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624199_224289.6666666666667298.0TransmembraneHelical%3B Name%3D5
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624251_267289.6666666666667298.0TransmembraneHelical%3B Name%3D6
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075624286_307289.6666666666667298.0TransmembraneHelical%3B Name%3D7
TgenePTGFRchr1:75677153chr1:79002091ENST000003707562432_54289.6666666666667298.0TransmembraneHelical%3B Name%3D1
TgenePTGFRchr1:75677153chr1:79002091ENST000003707562470_90289.6666666666667298.0TransmembraneHelical%3B Name%3D2
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713110_131266.0360.0TransmembraneHelical%3B Name%3D3
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713153_175266.0360.0TransmembraneHelical%3B Name%3D4
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713199_224266.0360.0TransmembraneHelical%3B Name%3D5
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075713251_267266.0360.0TransmembraneHelical%3B Name%3D6
TgenePTGFRchr1:75677153chr1:79002091ENST000003707571332_54266.0360.0TransmembraneHelical%3B Name%3D1
TgenePTGFRchr1:75677153chr1:79002091ENST000003707571370_90266.0360.0TransmembraneHelical%3B Name%3D2
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824110_131266.0360.0TransmembraneHelical%3B Name%3D3
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824153_175266.0360.0TransmembraneHelical%3B Name%3D4
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824199_224266.0360.0TransmembraneHelical%3B Name%3D5
TgenePTGFRchr1:75677153chr1:79002091ENST0000037075824251_267266.0360.0TransmembraneHelical%3B Name%3D6
TgenePTGFRchr1:75677153chr1:79002091ENST000003707582432_54266.0360.0TransmembraneHelical%3B Name%3D1
TgenePTGFRchr1:75677153chr1:79002091ENST000003707582470_90266.0360.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for SLC44A5-PTGFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000535611_ENST00000370758_TCGA-AR-A24Z-01A_SLC44A5_chr1_75677153_-_PTGFR_chr1_79002091_length(transcript)=5308nt_BP=1964nt
TGTGCTTTTTCCTAGAAAAACCAGCAGATACTCCCTCTGAGGAAGAGGACTTTGGTGATCCAAGGACATATGACCCAGATTTCAAGGGGC
CTGTTGCCAACAGGAGTTGTACAGATGTTCTGTGCTGTATGATCTTCCTACTGTGTATTATTGGCTACATTGTTTTAGGACTTGTGGGAA
CAAGACCATTTTGTTTTACTTTAACCTGTTACGCTGTACCAGTCCCTCCGTGTTGCTAAACCTACAGTGCCCTACCACACAGATCTGTGT
CTCCAAGTGCCCAGAAAAATTTTTAACCTATGTGGAAATGCAACTTTTGTACACAAAAGACAAAAGCTACTGGGAAGACTACCGTCAGTT
CTGTAAGACCACTGCTAAGCCTGTGAAGTCTCTCACACAGCTTTTACTGGATGATGATTGTCCAACAGCGATTTTTCCCAGCAAACCTTT
TCTCCAGAGATGTTTCCCTGACTTCTCTACCAAAAATGGCACTTTAACAATAGGAAGTAAGATGATGTTTCAAGATGGAAATGGAGGGAC
AAGAAGTGTTGTAGAACTCGGGATTGCTGCAAATGGTATCAATAAACTTCTTGATGCAAAGTCACTTGGATTGAAAGTGTTTGAAGACTA
TGCAAGAACTTGGTATTGGATTCTCATTGGCCTGACGATTGCCATGGTCCTTAGTTGGATATTTTTGATACTTCTGAGGTTCATAGCTGG
ATGCCTCTTCTGGGTCTTCATGATTGGTGTGATTGGAATTATAGGTTATGGAATATGGCACTGTTACCAGCAGTACACCAATCTTCAGGA
ACGCCCAAGTTCTGTATTAACTATCTATGACATCGGGATTCAGACTAACATAAGCATGTACTTTGAACTGCAACAAACATGGTTCACATT
TATGATAATACTCTGCATCATTGAAGTGATTGTCATCCTCATGCTGATCTTCCTCAGGAATCGAATCCGAGTCGCCATTATCCTGCTGAA
GGAAGGAAGCAAAGCCATTGGATATGTTCCTAGTACATTAGTCTATCCAGCTTTAACTTTCATTTTGCTCTCAATCTGCATTTGCTACTG
GGTCGTGACAGCAGTTTTCTTGGCGACATCGGGGGTACCTGTATACAAAGTCATAGCTCCAGGGGGGCATTGTATACATGAAAATCAAAC
CTGTGACCCAGAGATTTTTAATACAACTGAAATTGCCAAAGCTTGCCCTGGGGCTCTGTGTAACTTTGCTTTCTATGGTGGAAAGAGCTT
GTACCATCAGTACATCCCTACCTTCCATGTATACAACTTATTTGTCTTTCTCTGGCTTATAAACTTCGTCATTGCATTAGGTCAGTGCGC
CCTTGCTGGTGCATTCGCTACTTATTACTGGGCCATGAAAAAACCTGATGACATCCCACGATATCCACTTTTTACTGCATTTGGACGAGC
CATACGATATCACACAGGATCCCTAGCATTTGGATCTTTAATTATTGCATTAATTCAAATGTTTAAAATTGTACTAGAATACTTGGACCA
CCGTCTTAAACGTACCCAGAACACATTGTCTAAATTCCTACAATGCTGCCTGAGATGCTGCTTCTGGTGTTTGGAAAATGCAATAAAGTT
TTTAAACAGAAATGCCTATATTATGATTGCAATATATGGCAGAAACTTCTGCAGGTCAGCAAAAGATGCTTTCAATCTGCTGATGAGAAA
TGTTTTGAAAGTTGCAGTTACAGATGAAGTTACATACTTTGTATTATTCCTGGGGAAACTTCTAGTTGCTGGAAGTATAGGTGTTCTGGC
CTTCCTATTCTTCACACAAAGACTGCCAGTGATTGCACAAGGACCAGCATCTTTAAATTACTACTGGGTACCTTTGCTGACAGTCATTTT
TGGGTCTTACCTGATTGCACATGGGTTCTTCAGCGTCTATGCAATGTGTGTTGAAACAATTTTCATCTGCTTCTGTTACAATGGCCAACA
TTGGAATAAATGGAAATCATTCTCTGGAAACCTGTGAAACAACACTTTTTGCTCTCCGAATGGCAACATGGAATCAAATCTTAGATCCTT
GGGTATATATTCTTCTACGAAAGGCTGTCCTTAAGAATCTCTATAAGCTTGCCAGTCAATGCTGTGGAGTGCATGTCATCAGCTTACATA
TTTGGGAGCTTAGTTCCATTAAAAATTCCTTAAAGGTTGCTGCTATTTCTGAGTCACCAGTTGCAGAGAAATCAGCAAGCACCTAGCTTA
ATAGGACAGTAAATCTGTGTGGGGCTAGAACAAAATTAAGACATGTTTGGCAATATTTCAGTTAGTTAAATACCTGTAGCCTAACTGGAA
AATTCAGGCTTCATCATGTAGTTTGAAGATACTATTGTCAGATTCAGGTTTTGAAATTTGTCAAATAAACAGGATAACTGTACATTTTTC
ACTTGTTTTTGCCAATGGGAGGTAGACACAATAAAATAATGCCATGGGAGTCACACTGAAAGCAATTTTGAGCTTATCTGTCTTATTTAT
GCTTTGAGTGAATCATCTGTTGAGGTCTAATGCCTTTACTTGGCCTATTTGCCAGAGAACATCTTAATGCAGCCTGCATAGTGAAATGGT
TATTTTGAGATCACCGCTCTGTAGCTAACCCTTATAAACTAGGCTCAGTAAAATAAAGCACTCTTATTTTTTGATCTGGCCTATTTTGCC
CCTCATTGTGTAGCCTCAATTAACACATGCATGGTCATGACACCCAGAATTCATGATGGTTTGTTATAACAACCTCTGCATATTCCAGGT
CTGGCAGACAGGTTGCCTGACCCTGCAATCCTATCTAGAATGGGCCCATTCTTGTCATATTTGACAAATAGGACTGCCTACATTTATTAT
TATGAAGGTCGATTGTTGTTGGAAGTGTTTTTTCATGTCATAGATTAGCAATTTTCAAATAATTATTTTTTCTCTGAAAATTTTGTGTGT
GATTGCACAATAAATAATTTTTAGAGAAACAAAGGCTCTTTCTCAGCACATTGATGGGCAACTAGAATTACAGCAGTTTCAAAACTCTAC
CATGGATAATGCAAACAAACCGAAGCTACATGCCAATGATAGGTGCAAAGAATATTGGCAAAAGGTGCTTTACCTTGAGCCATTATTTGT
GTCAGAGAACAAAAGAAACAGAATCAATATATAAAATTCAAAGACTATCTGCAGCTAGTGTGTTTCTTCTTTACACACATATACACACAG
ACATCAGAAAATTCTGTTGAGAGCAGGTTCATTAAATTTGTAAGATGGCATATTCTAAAGCCTGTGCTACCAGTACTAAGAGGGGAAGAC
TGGCAATTTGCCAAGCACTTGGGGATTATTATAACAATTAACTAGGAGATCAAGAGATAATAATCTCTCCCCAAATTTTCCAATAATAAT
TGAGACTTTTTCTTTGCTTGTTTGTGTAATTCAACCAAAAGAATTTCAATACCCATTCAAATTGTCCTAGGTCTATCAGAAATTAGGGAA
GGTAGTCCTGCTTTATAATAGGAAAATGTATTTCTGTATAAGAGTTCTTTGCTTTCATTAACTTGGATTCATTTAAAAATTAATCTTCCC
TGTTAGGCTGATTTCAGATTCTCTAGGAAATCTGTGTAAGTAACCAGAAGACCTTTCAGATGGTTTATTTGCTTTCAGCAGAGAATTTAT
TTCATACAGTTACTTAAGAGTGTTGATGTCTTGTGAACAGAGATATAAGGAACCATTCTCCATCCTTCCTTATCATGCTGGGTACAATGC
TTCTATGAATATTTCCATGTATTTTGACTGGGGAGAGGCATGGAGAAGAAACTCTCATTCAGGGGCTCCAGGATCCTTCTCCTTGAGGCT
TCTAAATAAATGGCAGAATTCTTGCTGTATTGCCATGATGTCACCCTGGCCATGTGTACTGACTTGAGGAGATCTTGCAACATGGCCATG
TGCAAGGCTTTAAGGAGTGAGAGAGATGTGTACATATCTTAGGAGGGTTATCTATGTTATCTGAGTATATGTTTGGGTAACCAAATTGGT
CTTAAAAATGATGTTAACCCAAGAAGTAGACATCAAAAATTAAAAAAAAAAAAAGGAATGTGTTTTCATTGTTTTAAGTTTTTCTTCTGA
GTAAAACAAAATTATAGAAAACAAATGCAACAATGTGCACATCTGACTTAAGAGTTTCATTTCTGTTATTATATGTGTTGCATGTAGCTT
GGCGATTTACTGTGTAATGAATAATAGACTGGAACATCTACCAATAACTTTCACATAAATGTTCAAAATAGAAGTGTATTTTTTCAGGTT
TCTGGAAATAAATAGTAAAATAAATGGCACAAATAGTTTCAATAAATTTACCAATTTGAGTGTTTTCAGCTCTATTTCAAAACTCATAAC
TAATCTTCAGAATTACTGAATTTCCTTTTGAACTGGGTAAGGCATTATCCAAGCAACTTCACATACTATTTAAACATGATTTCTCGGTAA
TTATATATTCTGGGCAAATAACATAAACATGTCAGGATTTTTACAGGTGTTAGTGAATTTTTCTAAAAAGATGAGACAAAAGCAAAAATA
TCACACATAGGTTTTTATGACTATGAATACAAAGATAATGCTGATTCACAATTAGCTATGGGTAAGTCCAAAACATCAGACCTTTTACTG
ATGGGTTAACTAGGTGAAAGAAATGGGCCCTTATTTTTTTTTTTCCCTAGAGGCAGAAAGTTACTTCTAATGATCTATATAGCTAAAACG
AAAAATACCTGAAAGTTAATACATACATATGTAGATATATTTTGTTATGTGATAAATGTTTCTTGTTTGCACACTTTTGGACTTGAGAAA
TCTGCTTTTGTTTTGTGCCTACTCTGAGTTTAGAACCCAAATAAGAGGACTTGTTAAATATAGAGTGTACTTTTTGTTAAAACTATTGCT
AGCTTCACCTGTATACCATCATTGTTCCAAATTAAATAACTGTTTTGGGTCAGAATATAAATGCTGGGAATATACATTTTATTACTTCTT
AATCTGGGTGTCAAAGATTTTACCACCTGGTAAATAATGTTGGACTTCAACTTGTTACTGGCACATTTTAATAGTAGATGAAACATGTTT
TTCTTGGTTATGTGAATAAATGTATGTTGTGCTCTTCATACTTGTTGGATTGTATAGAGATTAAATAGTGATATGTATATTTTGTTGTTT

>In-frame_ENST00000535611_ENST00000370758_TCGA-AR-A24Z-01A_SLC44A5_chr1_75677153_-_PTGFR_chr1_79002091_length(amino acids)=636AA_start in transcript=106_stop in transcript=2016
MYRCSVLYDLPTVYYWLHCFRTCGNKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTA
KPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWY
WILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILC
IIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCDPEI
FNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHT
GSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVA
VTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCYNGQHWNKWK

--------------------------------------------------------------
>In-frame_ENST00000535611_ENST00000370757_TCGA-AR-A24Z-01A_SLC44A5_chr1_75677153_-_PTGFR_chr1_79002091_length(transcript)=5308nt_BP=1964nt
TGTGCTTTTTCCTAGAAAAACCAGCAGATACTCCCTCTGAGGAAGAGGACTTTGGTGATCCAAGGACATATGACCCAGATTTCAAGGGGC
CTGTTGCCAACAGGAGTTGTACAGATGTTCTGTGCTGTATGATCTTCCTACTGTGTATTATTGGCTACATTGTTTTAGGACTTGTGGGAA
CAAGACCATTTTGTTTTACTTTAACCTGTTACGCTGTACCAGTCCCTCCGTGTTGCTAAACCTACAGTGCCCTACCACACAGATCTGTGT
CTCCAAGTGCCCAGAAAAATTTTTAACCTATGTGGAAATGCAACTTTTGTACACAAAAGACAAAAGCTACTGGGAAGACTACCGTCAGTT
CTGTAAGACCACTGCTAAGCCTGTGAAGTCTCTCACACAGCTTTTACTGGATGATGATTGTCCAACAGCGATTTTTCCCAGCAAACCTTT
TCTCCAGAGATGTTTCCCTGACTTCTCTACCAAAAATGGCACTTTAACAATAGGAAGTAAGATGATGTTTCAAGATGGAAATGGAGGGAC
AAGAAGTGTTGTAGAACTCGGGATTGCTGCAAATGGTATCAATAAACTTCTTGATGCAAAGTCACTTGGATTGAAAGTGTTTGAAGACTA
TGCAAGAACTTGGTATTGGATTCTCATTGGCCTGACGATTGCCATGGTCCTTAGTTGGATATTTTTGATACTTCTGAGGTTCATAGCTGG
ATGCCTCTTCTGGGTCTTCATGATTGGTGTGATTGGAATTATAGGTTATGGAATATGGCACTGTTACCAGCAGTACACCAATCTTCAGGA
ACGCCCAAGTTCTGTATTAACTATCTATGACATCGGGATTCAGACTAACATAAGCATGTACTTTGAACTGCAACAAACATGGTTCACATT
TATGATAATACTCTGCATCATTGAAGTGATTGTCATCCTCATGCTGATCTTCCTCAGGAATCGAATCCGAGTCGCCATTATCCTGCTGAA
GGAAGGAAGCAAAGCCATTGGATATGTTCCTAGTACATTAGTCTATCCAGCTTTAACTTTCATTTTGCTCTCAATCTGCATTTGCTACTG
GGTCGTGACAGCAGTTTTCTTGGCGACATCGGGGGTACCTGTATACAAAGTCATAGCTCCAGGGGGGCATTGTATACATGAAAATCAAAC
CTGTGACCCAGAGATTTTTAATACAACTGAAATTGCCAAAGCTTGCCCTGGGGCTCTGTGTAACTTTGCTTTCTATGGTGGAAAGAGCTT
GTACCATCAGTACATCCCTACCTTCCATGTATACAACTTATTTGTCTTTCTCTGGCTTATAAACTTCGTCATTGCATTAGGTCAGTGCGC
CCTTGCTGGTGCATTCGCTACTTATTACTGGGCCATGAAAAAACCTGATGACATCCCACGATATCCACTTTTTACTGCATTTGGACGAGC
CATACGATATCACACAGGATCCCTAGCATTTGGATCTTTAATTATTGCATTAATTCAAATGTTTAAAATTGTACTAGAATACTTGGACCA
CCGTCTTAAACGTACCCAGAACACATTGTCTAAATTCCTACAATGCTGCCTGAGATGCTGCTTCTGGTGTTTGGAAAATGCAATAAAGTT
TTTAAACAGAAATGCCTATATTATGATTGCAATATATGGCAGAAACTTCTGCAGGTCAGCAAAAGATGCTTTCAATCTGCTGATGAGAAA
TGTTTTGAAAGTTGCAGTTACAGATGAAGTTACATACTTTGTATTATTCCTGGGGAAACTTCTAGTTGCTGGAAGTATAGGTGTTCTGGC
CTTCCTATTCTTCACACAAAGACTGCCAGTGATTGCACAAGGACCAGCATCTTTAAATTACTACTGGGTACCTTTGCTGACAGTCATTTT
TGGGTCTTACCTGATTGCACATGGGTTCTTCAGCGTCTATGCAATGTGTGTTGAAACAATTTTCATCTGCTTCTGTTACAATGGCCAACA
TTGGAATAAATGGAAATCATTCTCTGGAAACCTGTGAAACAACACTTTTTGCTCTCCGAATGGCAACATGGAATCAAATCTTAGATCCTT
GGGTATATATTCTTCTACGAAAGGCTGTCCTTAAGAATCTCTATAAGCTTGCCAGTCAATGCTGTGGAGTGCATGTCATCAGCTTACATA
TTTGGGAGCTTAGTTCCATTAAAAATTCCTTAAAGGTTGCTGCTATTTCTGAGTCACCAGTTGCAGAGAAATCAGCAAGCACCTAGCTTA
ATAGGACAGTAAATCTGTGTGGGGCTAGAACAAAATTAAGACATGTTTGGCAATATTTCAGTTAGTTAAATACCTGTAGCCTAACTGGAA
AATTCAGGCTTCATCATGTAGTTTGAAGATACTATTGTCAGATTCAGGTTTTGAAATTTGTCAAATAAACAGGATAACTGTACATTTTTC
ACTTGTTTTTGCCAATGGGAGGTAGACACAATAAAATAATGCCATGGGAGTCACACTGAAAGCAATTTTGAGCTTATCTGTCTTATTTAT
GCTTTGAGTGAATCATCTGTTGAGGTCTAATGCCTTTACTTGGCCTATTTGCCAGAGAACATCTTAATGCAGCCTGCATAGTGAAATGGT
TATTTTGAGATCACCGCTCTGTAGCTAACCCTTATAAACTAGGCTCAGTAAAATAAAGCACTCTTATTTTTTGATCTGGCCTATTTTGCC
CCTCATTGTGTAGCCTCAATTAACACATGCATGGTCATGACACCCAGAATTCATGATGGTTTGTTATAACAACCTCTGCATATTCCAGGT
CTGGCAGACAGGTTGCCTGACCCTGCAATCCTATCTAGAATGGGCCCATTCTTGTCATATTTGACAAATAGGACTGCCTACATTTATTAT
TATGAAGGTCGATTGTTGTTGGAAGTGTTTTTTCATGTCATAGATTAGCAATTTTCAAATAATTATTTTTTCTCTGAAAATTTTGTGTGT
GATTGCACAATAAATAATTTTTAGAGAAACAAAGGCTCTTTCTCAGCACATTGATGGGCAACTAGAATTACAGCAGTTTCAAAACTCTAC
CATGGATAATGCAAACAAACCGAAGCTACATGCCAATGATAGGTGCAAAGAATATTGGCAAAAGGTGCTTTACCTTGAGCCATTATTTGT
GTCAGAGAACAAAAGAAACAGAATCAATATATAAAATTCAAAGACTATCTGCAGCTAGTGTGTTTCTTCTTTACACACATATACACACAG
ACATCAGAAAATTCTGTTGAGAGCAGGTTCATTAAATTTGTAAGATGGCATATTCTAAAGCCTGTGCTACCAGTACTAAGAGGGGAAGAC
TGGCAATTTGCCAAGCACTTGGGGATTATTATAACAATTAACTAGGAGATCAAGAGATAATAATCTCTCCCCAAATTTTCCAATAATAAT
TGAGACTTTTTCTTTGCTTGTTTGTGTAATTCAACCAAAAGAATTTCAATACCCATTCAAATTGTCCTAGGTCTATCAGAAATTAGGGAA
GGTAGTCCTGCTTTATAATAGGAAAATGTATTTCTGTATAAGAGTTCTTTGCTTTCATTAACTTGGATTCATTTAAAAATTAATCTTCCC
TGTTAGGCTGATTTCAGATTCTCTAGGAAATCTGTGTAAGTAACCAGAAGACCTTTCAGATGGTTTATTTGCTTTCAGCAGAGAATTTAT
TTCATACAGTTACTTAAGAGTGTTGATGTCTTGTGAACAGAGATATAAGGAACCATTCTCCATCCTTCCTTATCATGCTGGGTACAATGC
TTCTATGAATATTTCCATGTATTTTGACTGGGGAGAGGCATGGAGAAGAAACTCTCATTCAGGGGCTCCAGGATCCTTCTCCTTGAGGCT
TCTAAATAAATGGCAGAATTCTTGCTGTATTGCCATGATGTCACCCTGGCCATGTGTACTGACTTGAGGAGATCTTGCAACATGGCCATG
TGCAAGGCTTTAAGGAGTGAGAGAGATGTGTACATATCTTAGGAGGGTTATCTATGTTATCTGAGTATATGTTTGGGTAACCAAATTGGT
CTTAAAAATGATGTTAACCCAAGAAGTAGACATCAAAAATTAAAAAAAAAAAAAGGAATGTGTTTTCATTGTTTTAAGTTTTTCTTCTGA
GTAAAACAAAATTATAGAAAACAAATGCAACAATGTGCACATCTGACTTAAGAGTTTCATTTCTGTTATTATATGTGTTGCATGTAGCTT
GGCGATTTACTGTGTAATGAATAATAGACTGGAACATCTACCAATAACTTTCACATAAATGTTCAAAATAGAAGTGTATTTTTTCAGGTT
TCTGGAAATAAATAGTAAAATAAATGGCACAAATAGTTTCAATAAATTTACCAATTTGAGTGTTTTCAGCTCTATTTCAAAACTCATAAC
TAATCTTCAGAATTACTGAATTTCCTTTTGAACTGGGTAAGGCATTATCCAAGCAACTTCACATACTATTTAAACATGATTTCTCGGTAA
TTATATATTCTGGGCAAATAACATAAACATGTCAGGATTTTTACAGGTGTTAGTGAATTTTTCTAAAAAGATGAGACAAAAGCAAAAATA
TCACACATAGGTTTTTATGACTATGAATACAAAGATAATGCTGATTCACAATTAGCTATGGGTAAGTCCAAAACATCAGACCTTTTACTG
ATGGGTTAACTAGGTGAAAGAAATGGGCCCTTATTTTTTTTTTTCCCTAGAGGCAGAAAGTTACTTCTAATGATCTATATAGCTAAAACG
AAAAATACCTGAAAGTTAATACATACATATGTAGATATATTTTGTTATGTGATAAATGTTTCTTGTTTGCACACTTTTGGACTTGAGAAA
TCTGCTTTTGTTTTGTGCCTACTCTGAGTTTAGAACCCAAATAAGAGGACTTGTTAAATATAGAGTGTACTTTTTGTTAAAACTATTGCT
AGCTTCACCTGTATACCATCATTGTTCCAAATTAAATAACTGTTTTGGGTCAGAATATAAATGCTGGGAATATACATTTTATTACTTCTT
AATCTGGGTGTCAAAGATTTTACCACCTGGTAAATAATGTTGGACTTCAACTTGTTACTGGCACATTTTAATAGTAGATGAAACATGTTT
TTCTTGGTTATGTGAATAAATGTATGTTGTGCTCTTCATACTTGTTGGATTGTATAGAGATTAAATAGTGATATGTATATTTTGTTGTTT

>In-frame_ENST00000535611_ENST00000370757_TCGA-AR-A24Z-01A_SLC44A5_chr1_75677153_-_PTGFR_chr1_79002091_length(amino acids)=636AA_start in transcript=106_stop in transcript=2016
MYRCSVLYDLPTVYYWLHCFRTCGNKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTA
KPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWY
WILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILC
IIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCDPEI
FNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHT
GSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVA
VTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCYNGQHWNKWK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC44A5-PTGFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC44A5-PTGFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC44A5-PTGFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTGFRC0001883Airway Obstruction1CTD_human
TgenePTGFRC0008301Choking1CTD_human
TgenePTGFRC0014175Endometriosis1CTD_human
TgenePTGFRC0269102Endometrioma1CTD_human