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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:SLC4A4-GOLGA4 (FusionGDB2 ID:82802)

Fusion Gene Summary for SLC4A4-GOLGA4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC4A4-GOLGA4
Fusion gene ID: 82802
HgeneTgene
Gene symbol

SLC4A4

GOLGA4

Gene ID

8671

2803

Gene namesolute carrier family 4 member 4golgin A4
SynonymsHNBC1|KNBC|NBC1|NBC2|NBCe1-A|SLC4A5|hhNMC|kNBC1|pNBCCRPF46|GCP2|GOLG|MU-RMS-40.18|p230
Cytomap

4q13.3

3p22.2

Type of geneprotein-codingprotein-coding
Descriptionelectrogenic sodium bicarbonate cotransporter 1Na(+)/HCO3(-) cotransportersodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)solute carrier family 4 (sodium bicarbonate cotransportergolgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230
Modification date2020031320200313
UniProtAcc.

Q13439

Ensembl transtripts involved in fusion geneENST00000264485, ENST00000425175, 
ENST00000351898, ENST00000340595, 
ENST00000514331, ENST00000512686, 
ENST00000361924, ENST00000435830, 
ENST00000444882, ENST00000356847, 
Fusion gene scores* DoF score12 X 12 X 5=72014 X 16 X 6=1344
# samples 1315
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1344*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC4A4 [Title/Abstract] AND GOLGA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC4A4(72413437)-GOLGA4(37396592), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC4A4

GO:0006814

sodium ion transport

16769890

HgeneSLC4A4

GO:0015701

bicarbonate transport

10069984

HgeneSLC4A4

GO:0035725

sodium ion transmembrane transport

10069984

HgeneSLC4A4

GO:0042391

regulation of membrane potential

10069984|15273250

HgeneSLC4A4

GO:0051453

regulation of intracellular pH

10069984

TgeneGOLGA4

GO:0043001

Golgi to plasma membrane protein transport

15265687

TgeneGOLGA4

GO:0045773

positive regulation of axon extension

22705394


check buttonFusion gene breakpoints across SLC4A4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GOLGA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VP-A875-01ASLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
ChimerDB4PRADTCGA-VP-A875SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
ChimerDB4PRADTCGA-VP-A875-01ASLC4A4chr4

72413437

-GOLGA4chr3

37396592

+


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Fusion Gene ORF analysis for SLC4A4-GOLGA4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264485ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000264485ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000264485ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000264485ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
In-frameENST00000425175ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000425175ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000425175ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000425175ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-3CDSENST00000351898ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000351898ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000351898ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000351898ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
In-frameENST00000340595ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000340595ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000340595ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
5CDS-intronENST00000340595ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-3CDSENST00000514331ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000514331ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000514331ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000514331ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-3CDSENST00000512686ENST00000361924SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000512686ENST00000435830SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000512686ENST00000444882SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+
intron-intronENST00000512686ENST00000356847SLC4A4chr4

72413437

+GOLGA4chr3

37396592

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264485SLC4A4chr472413437+ENST00000361924GOLGA4chr337396592+36332811842927947
ENST00000425175SLC4A4chr472413437+ENST00000361924GOLGA4chr337396592+36332811842927947
ENST00000340595SLC4A4chr472413437+ENST00000361924GOLGA4chr337396592+358027581752874899

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264485ENST00000361924SLC4A4chr472413437+GOLGA4chr337396592+0.0001635550.99983644
ENST00000425175ENST00000361924SLC4A4chr472413437+GOLGA4chr337396592+0.0001635550.99983644
ENST00000340595ENST00000361924SLC4A4chr472413437+GOLGA4chr337396592+0.000347410.9996526

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Fusion Genomic Features for SLC4A4-GOLGA4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC4A4chr472413437+GOLGA4chr337396591+1.27E-050.99998724
SLC4A4chr472413437+GOLGA4chr337396591+1.27E-050.99998724
SLC4A4chr472413437+GOLGA4chr337396591+1.27E-050.99998724
SLC4A4chr472413437+GOLGA4chr337396591+1.27E-050.99998724

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC4A4-GOLGA4


check button Go to

FGviewer for the breakpoints of chr4:72413437-chr3:37396592

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GOLGA4

Q13439

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:29084197}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+20261_466898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026492_501898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026521_521898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026543_550898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026572_585898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026610_692898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026711_725898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026746_779898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026808_819898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026837_837898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026856_877898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026895_901898.01684.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+17231_466854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723492_501854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723521_521854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723543_550854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723572_585854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723610_692854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723711_725854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723746_779854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723808_819854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723837_837854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+20251_466898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025492_501898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025521_521898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025543_550898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025572_585898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025610_692898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025711_725898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025746_779898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025808_819898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025837_837898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025856_877898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025895_901898.01095.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026467_491898.01684.6666666666667TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026502_520898.01684.6666666666667TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026522_542898.01684.6666666666667TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026551_571898.01684.6666666666667TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026586_609898.01684.6666666666667TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026693_710898.01684.6666666666667TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026726_745898.01684.6666666666667TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026780_807898.01684.6666666666667TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026820_836898.01684.6666666666667TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026838_855898.01684.6666666666667TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026878_894898.01684.6666666666667TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723467_491854.02318.3333333333335TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723502_520854.02318.3333333333335TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723522_542854.02318.3333333333335TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723551_571854.02318.3333333333335TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723586_609854.02318.3333333333335TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723693_710854.02318.3333333333335TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723726_745854.02318.3333333333335TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723780_807854.02318.3333333333335TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723820_836854.02318.3333333333335TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723838_855854.02318.3333333333335TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025467_491898.01095.0TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025502_520898.01095.0TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025522_542898.01095.0TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025551_571898.01095.0TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025586_609898.01095.0TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025693_710898.01095.0TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025726_745898.01095.0TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025780_807898.01095.0TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025820_836898.01095.0TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025838_855898.01095.0TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025878_894898.01095.0TransmembraneHelical%3B Name%3D11

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+20261009_1024898.01684.6666666666667Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+17231009_1024854.02318.3333333333335Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+1241009_102401194.6666666666667Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+20251009_1024898.01095.0Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+1111009_10240647.0Compositional biasNote=Lys-rich
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026961_986898.01684.6666666666667IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723961_986854.02318.3333333333335IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124961_98601194.6666666666667IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025961_986898.01095.0IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111961_9860647.0IntramembraneDiscontinuously helical
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+20261002_1004898.01684.6666666666667RegionNote=CA2-binding
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+20261057_1059898.01684.6666666666667RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+17231002_1004854.02318.3333333333335RegionNote=CA2-binding
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+17231057_1059854.02318.3333333333335RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+1241002_100401194.6666666666667RegionNote=CA2-binding
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+1241057_105901194.6666666666667RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+20251002_1004898.01095.0RegionNote=CA2-binding
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+20251057_1059898.01095.0RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+1111002_10040647.0RegionNote=CA2-binding
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+1111057_10590647.0RegionNote=Required for basolateral targeting
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026919_960898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026987_1079898.01684.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723856_877854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723895_901854.02318.3333333333335Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723919_960854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723987_1079854.02318.3333333333335Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+1241_46601194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124492_50101194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124521_52101194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124543_55001194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124572_58501194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124610_69201194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124711_72501194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124746_77901194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124808_81901194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124837_83701194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124856_87701194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124895_90101194.6666666666667Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124919_96001194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124987_107901194.6666666666667Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025919_960898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025987_1079898.01095.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+1111_4660647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111492_5010647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111521_5210647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111543_5500647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111572_5850647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111610_6920647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111711_7250647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111746_7790647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111808_8190647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111837_8370647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111856_8770647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111895_9010647.0Topological domainExtracellular
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111919_9600647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111987_10790647.0Topological domainCytoplasmic
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026902_918898.01684.6666666666667TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723878_894854.02318.3333333333335TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723902_918854.02318.3333333333335TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124467_49101194.6666666666667TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124502_52001194.6666666666667TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124522_54201194.6666666666667TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124551_57101194.6666666666667TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124586_60901194.6666666666667TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124693_71001194.6666666666667TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124726_74501194.6666666666667TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124780_80701194.6666666666667TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124820_83601194.6666666666667TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124838_85501194.6666666666667TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124878_89401194.6666666666667TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124902_91801194.6666666666667TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025902_918898.01095.0TransmembraneHelical%3B Name%3D12
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111467_4910647.0TransmembraneHelical%3B Name%3D1
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111502_5200647.0TransmembraneHelical%3B Name%3D2
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111522_5420647.0TransmembraneDiscontinuously helical%3B Name%3D3
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111551_5710647.0TransmembraneHelical%3B Name%3D4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111586_6090647.0TransmembraneHelical%3B Name%3D5
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111693_7100647.0TransmembraneHelical%3B Name%3D6
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111726_7450647.0TransmembraneHelical%3B Name%3D7
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111780_8070647.0TransmembraneHelical%3B Name%3D8
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111820_8360647.0TransmembraneHelical%3B Name%3D9
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111838_8550647.0TransmembraneDiscontinuously helical%3B Name%3D10
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111878_8940647.0TransmembraneHelical%3B Name%3D11
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111902_9180647.0TransmembraneHelical%3B Name%3D12
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003568472023133_21852207.02244.0Coiled coilOntology_term=ECO:0000255
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003619242024133_21852192.02306.3333333333335Coiled coilOntology_term=ECO:0000255
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003568472023252_20962207.02244.0Compositional biasNote=Glu-rich
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003619242024252_20962192.02306.3333333333335Compositional biasNote=Glu-rich
TgeneGOLGA4chr4:72413437chr3:37396592ENST0000035684720232168_22152207.02244.0DomainGRIP
TgeneGOLGA4chr4:72413437chr3:37396592ENST0000036192420242168_22152192.02306.3333333333335DomainGRIP


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Fusion Gene Sequence for SLC4A4-GOLGA4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000264485_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(transcript)=3633nt_BP=2811nt
GCGGCGGCGGCCGCGGTGGCAGCGAAGGCGGCGGCGGCGGCGGCAGTGGCAGTGGCCGCTGCAGCCCCACACTCCGCCGCCAAACTGGAG
GAGCGACGGAAGCCAGACCCCAGGAGGATGGAGGATGAAGCTGTCCTGGACAGAGGGGCTTCCTTCCTCAAGCATGTGTGTGATGAAGAA
GAAGTAGAAGGCCACCATACCATTTACATCGGAGTCCATGTGCCGAAGAGTTACAGGAGAAGGAGACGTCACAAGAGAAAGACAGGGCAC
AAAGAAAAGAAGGAAAAGGAGAGAATCTCTGAGAACTACTCTGACAAATCAGATATTGAAAATGCTGATGAATCCAGCAGCAGCATCCTA
AAACCTCTCATCTCTCCTGCTGCAGAACGCATCCGATTCATCTTGGGAGAGGAGGATGACAGCCCAGCTCCCCCTCAGCTCTTCACGGAA
CTGGATGAGCTGCTGGCCGTGGATGGGCAGGAGATGGAGTGGAAGGAAACAGCCAGGTGGATCAAGTTTGAAGAAAAAGTGGAACAGGGT
GGGGAAAGATGGAGCAAGCCCCATGTGGCCACATTGTCCCTTCATAGTTTATTTGAGCTGAGGACATGTATGGAGAAAGGATCCATCATG
CTTGATCGGGAGGCTTCTTCTCTCCCACAGTTGGTGGAGATGATTGTTGACCATCAGATTGAGACAGGCCTATTGAAACCTGAACTTAAG
GATAAGGTGACCTATACTTTGCTCCGGAAGCACCGGCATCAAACCAAGAAATCCAACCTTCGGTCCCTGGCTGACATTGGGAAGACAGTC
TCCAGTGCAAGTAGGATGTTTACCAACCCTGATAATGGTAGCCCAGCCATGACCCATAGGAATCTGACTTCCTCCAGTCTGAATGACATT
TCTGATAAACCGGAGAAGGACCAGCTGAAGAATAAGTTCATGAAAAAATTGCCACGTGATGCAGAAGCTTCCAACGTGCTTGTTGGGGAG
GTTGACTTTTTGGATACTCCTTTCATTGCCTTTGTTAGGCTACAGCAGGCTGTCATGCTGGGTGCCCTGACTGAAGTTCCTGTGCCCACA
AGGTTCTTGTTCATTCTCTTAGGTCCTAAGGGGAAAGCCAAGTCCTACCACGAGATTGGCAGAGCCATTGCCACCCTGATGTCTGATGAG
GTGTTCCATGACATTGCTTATAAAGCAAAAGACAGGCACGACCTGATTGCTGGTATTGATGAGTTCCTAGATGAAGTCATCGTCCTTCCA
CCTGGGGAATGGGATCCAGCAATTAGGATAGAGCCTCCTAAGAGTCTTCCATCCTCTGACAAAAGAAAGAATATGTACTCAGGTGGAGAG
AATGTTCAGATGAATGGGGATACGCCCCATGATGGAGGTCACGGAGGAGGAGGACATGGGGATTGTGAAGAATTGCAGCGAACTGGACGG
TTCTGTGGTGGACTAATTAAAGACATAAAGAGGAAAGCGCCATTTTTTGCCAGTGATTTTTATGATGCTTTAAATATTCAAGCTCTTTCG
GCAATTCTCTTCATTTATCTGGCAACTGTAACTAATGCTATCACTTTTGGAGGACTGCTTGGGGATGCCACTGACAACATGCAGGGCGTG
TTGGAGAGTTTCCTGGGCACTGCTGTCTCTGGAGCCATCTTTTGCCTTTTTGCTGGTCAACCACTCACTATTCTGAGCAGCACCGGACCT
GTCCTAGTTTTTGAGAGGCTTCTATTTAATTTCAGCAAGGACAATAATTTTGACTATTTGGAGTTTCGCCTTTGGATTGGCCTGTGGTCC
GCCTTCCTATGTCTCATTTTGGTAGCCACTGATGCCAGCTTCTTGGTTCAATACTTCACACGTTTCACGGAGGAGGGCTTTTCCTCTCTG
ATTAGCTTCATCTTTATCTATGATGCTTTCAAGAAGATGATCAAGCTTGCAGATTACTACCCCATCAACTCCAACTTCAAAGTGGGCTAC
AACACTCTCTTTTCCTGTACCTGTGTGCCACCTGACCCAGCTAATATCTCAATATCTAATGACACCACACTGGCCCCAGAGTATTTGCCA
ACTATGTCTTCTACTGACATGTACCATAATACTACCTTTGACTGGGCATTTTTGTCGAAGAAGGAGTGTTCAAAATACGGAGGAAACCTC
GTCGGGAACAACTGTAATTTTGTTCCTGATATCACACTCATGTCTTTTATCCTCTTCTTGGGAACCTACACCTCTTCCATGGCTCTGAAA
AAATTCAAAACTAGTCCTTATTTTCCAACCACAGCAAGAAAACTGATCAGTGATTTTGCCATTATCTTGTCCATTCTCATCTTTTGTGTA
ATAGATGCCCTAGTAGGCGTGGACACCCCAAAACTAATTGTGCCAAGTGAGTTCAAGCCAACAAGTCCAAACCGAGGTTGGTTCGTTCCA
CCGTTTGGAGAAAACCCCTGGTGGGTGTGCCTTGCTGCTGCTATCCCGGCTTTGTTGGTCACTATACTGATTTTCATGGACCAACAAATT
ACAGCTGTGATTGTAAACAGGAAAGAACATAAACTCAAGAAAGGAGCAGGGTATCACTTGGATCTCTTTTGGGTGGCCATCCTCATGGTT
ATATGCTCCCTCATGGCTCTTCCGTGGTATGTAGCTGCTACGGTCATCTCCATTGCTCACATCGACAGTTTGAAGATGGAGACAGAGACT
TCTGCACCTGGAGAACAACCAAAGTTTCTAGGAGTGAGGGAACAAAGAGTCACTGGAACCCTTGTGTTTATTCTGACTGGTCTGTCAGTC
TTTATGGCTCCCATCTTGAAGACCATGGCAAAAGTTATAACCACCGTACTGAAGTTCCCTGATGATCAGACTCAGAAAATTTTGGAAAGA
GAAGATGCTCGGCTGATGTTTACTTCACCTCGCAGTGGTATCTTCTGAGTAAACCATCAGTCTGTGCTTAGTTAACATGTGTCATGGCTC
CGATCTTCATCTTGAAGAAGAGTGACATTGGGTGACTGCTGCTTGGAAAACTGTCCACACTTGCTACTCTTTGAGAATGAAGTTGTCATT
CAGGGCCCCTCATGTAGCCAAAAGACCAAGAAAAATCTGGCCCACAGATAAGTTGCAGACTGCCTTTAAAATAGATTTTATCAGTGGAGA
AATGGTGATAGTTTTTTCTTCAGTTTTCTCTTGGGAAGAGTTTTATGTTGTTTAAAAGATATTTTGATAACTTAACCTGCTTTATGGGCT
TACATAATATTCCTTTCATCCATTCTTTTTAAAGAACGGCTTACCTTTCCTATTTATTTTTAGGGTGATTTTTTAAAAAGACTTGTGCAA
TACATTTTGAGGTGAAACTTAGTGGATTTTTTCTGATAAATTAGAGCATTTAATTGACTATTTTATTCAGGTTGATCTGTTGAATATTTG
CTAAAGACCAGTTCTTTAAGCTAAGACATGTAAAAAATCCCAAATGGCAGTACCTCATTGTTTACTTAGCTTTTGTACTTATATTTTTCA
GAGGAAAAAACACTACTGTAAATTGTGAATAGCCAATACATAACTGTATTGTATGCAAATCTGTGATTGTTGGCAGTGTCATCTCTGAGA

>In-frame_ENST00000264485_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(amino acids)=947AA_start in transcript=84_stop in transcript=2927
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS
ILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGS
IMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLN
DISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMS
DEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRT
GRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSST
GPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKV
GYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMA
LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQ
QITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGL

--------------------------------------------------------------
>In-frame_ENST00000425175_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(transcript)=3633nt_BP=2811nt
GCGGCGGCGGCCGCGGTGGCAGCGAAGGCGGCGGCGGCGGCGGCAGTGGCAGTGGCCGCTGCAGCCCCACACTCCGCCGCCAAACTGGAG
GAGCGACGGAAGCCAGACCCCAGGAGGATGGAGGATGAAGCTGTCCTGGACAGAGGGGCTTCCTTCCTCAAGCATGTGTGTGATGAAGAA
GAAGTAGAAGGCCACCATACCATTTACATCGGAGTCCATGTGCCGAAGAGTTACAGGAGAAGGAGACGTCACAAGAGAAAGACAGGGCAC
AAAGAAAAGAAGGAAAAGGAGAGAATCTCTGAGAACTACTCTGACAAATCAGATATTGAAAATGCTGATGAATCCAGCAGCAGCATCCTA
AAACCTCTCATCTCTCCTGCTGCAGAACGCATCCGATTCATCTTGGGAGAGGAGGATGACAGCCCAGCTCCCCCTCAGCTCTTCACGGAA
CTGGATGAGCTGCTGGCCGTGGATGGGCAGGAGATGGAGTGGAAGGAAACAGCCAGGTGGATCAAGTTTGAAGAAAAAGTGGAACAGGGT
GGGGAAAGATGGAGCAAGCCCCATGTGGCCACATTGTCCCTTCATAGTTTATTTGAGCTGAGGACATGTATGGAGAAAGGATCCATCATG
CTTGATCGGGAGGCTTCTTCTCTCCCACAGTTGGTGGAGATGATTGTTGACCATCAGATTGAGACAGGCCTATTGAAACCTGAACTTAAG
GATAAGGTGACCTATACTTTGCTCCGGAAGCACCGGCATCAAACCAAGAAATCCAACCTTCGGTCCCTGGCTGACATTGGGAAGACAGTC
TCCAGTGCAAGTAGGATGTTTACCAACCCTGATAATGGTAGCCCAGCCATGACCCATAGGAATCTGACTTCCTCCAGTCTGAATGACATT
TCTGATAAACCGGAGAAGGACCAGCTGAAGAATAAGTTCATGAAAAAATTGCCACGTGATGCAGAAGCTTCCAACGTGCTTGTTGGGGAG
GTTGACTTTTTGGATACTCCTTTCATTGCCTTTGTTAGGCTACAGCAGGCTGTCATGCTGGGTGCCCTGACTGAAGTTCCTGTGCCCACA
AGGTTCTTGTTCATTCTCTTAGGTCCTAAGGGGAAAGCCAAGTCCTACCACGAGATTGGCAGAGCCATTGCCACCCTGATGTCTGATGAG
GTGTTCCATGACATTGCTTATAAAGCAAAAGACAGGCACGACCTGATTGCTGGTATTGATGAGTTCCTAGATGAAGTCATCGTCCTTCCA
CCTGGGGAATGGGATCCAGCAATTAGGATAGAGCCTCCTAAGAGTCTTCCATCCTCTGACAAAAGAAAGAATATGTACTCAGGTGGAGAG
AATGTTCAGATGAATGGGGATACGCCCCATGATGGAGGTCACGGAGGAGGAGGACATGGGGATTGTGAAGAATTGCAGCGAACTGGACGG
TTCTGTGGTGGACTAATTAAAGACATAAAGAGGAAAGCGCCATTTTTTGCCAGTGATTTTTATGATGCTTTAAATATTCAAGCTCTTTCG
GCAATTCTCTTCATTTATCTGGCAACTGTAACTAATGCTATCACTTTTGGAGGACTGCTTGGGGATGCCACTGACAACATGCAGGGCGTG
TTGGAGAGTTTCCTGGGCACTGCTGTCTCTGGAGCCATCTTTTGCCTTTTTGCTGGTCAACCACTCACTATTCTGAGCAGCACCGGACCT
GTCCTAGTTTTTGAGAGGCTTCTATTTAATTTCAGCAAGGACAATAATTTTGACTATTTGGAGTTTCGCCTTTGGATTGGCCTGTGGTCC
GCCTTCCTATGTCTCATTTTGGTAGCCACTGATGCCAGCTTCTTGGTTCAATACTTCACACGTTTCACGGAGGAGGGCTTTTCCTCTCTG
ATTAGCTTCATCTTTATCTATGATGCTTTCAAGAAGATGATCAAGCTTGCAGATTACTACCCCATCAACTCCAACTTCAAAGTGGGCTAC
AACACTCTCTTTTCCTGTACCTGTGTGCCACCTGACCCAGCTAATATCTCAATATCTAATGACACCACACTGGCCCCAGAGTATTTGCCA
ACTATGTCTTCTACTGACATGTACCATAATACTACCTTTGACTGGGCATTTTTGTCGAAGAAGGAGTGTTCAAAATACGGAGGAAACCTC
GTCGGGAACAACTGTAATTTTGTTCCTGATATCACACTCATGTCTTTTATCCTCTTCTTGGGAACCTACACCTCTTCCATGGCTCTGAAA
AAATTCAAAACTAGTCCTTATTTTCCAACCACAGCAAGAAAACTGATCAGTGATTTTGCCATTATCTTGTCCATTCTCATCTTTTGTGTA
ATAGATGCCCTAGTAGGCGTGGACACCCCAAAACTAATTGTGCCAAGTGAGTTCAAGCCAACAAGTCCAAACCGAGGTTGGTTCGTTCCA
CCGTTTGGAGAAAACCCCTGGTGGGTGTGCCTTGCTGCTGCTATCCCGGCTTTGTTGGTCACTATACTGATTTTCATGGACCAACAAATT
ACAGCTGTGATTGTAAACAGGAAAGAACATAAACTCAAGAAAGGAGCAGGGTATCACTTGGATCTCTTTTGGGTGGCCATCCTCATGGTT
ATATGCTCCCTCATGGCTCTTCCGTGGTATGTAGCTGCTACGGTCATCTCCATTGCTCACATCGACAGTTTGAAGATGGAGACAGAGACT
TCTGCACCTGGAGAACAACCAAAGTTTCTAGGAGTGAGGGAACAAAGAGTCACTGGAACCCTTGTGTTTATTCTGACTGGTCTGTCAGTC
TTTATGGCTCCCATCTTGAAGACCATGGCAAAAGTTATAACCACCGTACTGAAGTTCCCTGATGATCAGACTCAGAAAATTTTGGAAAGA
GAAGATGCTCGGCTGATGTTTACTTCACCTCGCAGTGGTATCTTCTGAGTAAACCATCAGTCTGTGCTTAGTTAACATGTGTCATGGCTC
CGATCTTCATCTTGAAGAAGAGTGACATTGGGTGACTGCTGCTTGGAAAACTGTCCACACTTGCTACTCTTTGAGAATGAAGTTGTCATT
CAGGGCCCCTCATGTAGCCAAAAGACCAAGAAAAATCTGGCCCACAGATAAGTTGCAGACTGCCTTTAAAATAGATTTTATCAGTGGAGA
AATGGTGATAGTTTTTTCTTCAGTTTTCTCTTGGGAAGAGTTTTATGTTGTTTAAAAGATATTTTGATAACTTAACCTGCTTTATGGGCT
TACATAATATTCCTTTCATCCATTCTTTTTAAAGAACGGCTTACCTTTCCTATTTATTTTTAGGGTGATTTTTTAAAAAGACTTGTGCAA
TACATTTTGAGGTGAAACTTAGTGGATTTTTTCTGATAAATTAGAGCATTTAATTGACTATTTTATTCAGGTTGATCTGTTGAATATTTG
CTAAAGACCAGTTCTTTAAGCTAAGACATGTAAAAAATCCCAAATGGCAGTACCTCATTGTTTACTTAGCTTTTGTACTTATATTTTTCA
GAGGAAAAAACACTACTGTAAATTGTGAATAGCCAATACATAACTGTATTGTATGCAAATCTGTGATTGTTGGCAGTGTCATCTCTGAGA

>In-frame_ENST00000425175_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(amino acids)=947AA_start in transcript=84_stop in transcript=2927
MEERRKPDPRRMEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKTGHKEKKEKERISENYSDKSDIENADESSSS
ILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGS
IMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLN
DISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMS
DEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRT
GRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSST
GPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKV
GYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMA
LKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQ
QITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGL

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>In-frame_ENST00000340595_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(transcript)=3580nt_BP=2758nt
AGGAGGGGAAGTGAGTGGTTAGACCTCAGCTCATCTGAGGGCTAAAGGTTCTTTGTGACACATCACACAGAATTGGAGTGCTGTCCTTCT
GGAGAGTGGTGGAGAACCAAGATACAGTTCAGAACCAAAGGAATAGAGAAGGGCTTTGATTTCTTTTTGGCTTTAGATTGGGGATTTGGG
AGGCTTAGCAGGAAAGATGTCCACTGAAAATGTGGAAGGGAAGCCCAGTAACCTTGGGGAGAGAGGAAGAGCCCGGAGCTCCACTTTCCT
CAGGGTTGTCCAGCCAATGTTTAACCACAGTATTTTCACTTCTGCAGTCTCTCCTGCTGCAGAACGCATCCGATTCATCTTGGGAGAGGA
GGATGACAGCCCAGCTCCCCCTCAGCTCTTCACGGAACTGGATGAGCTGCTGGCCGTGGATGGGCAGGAGATGGAGTGGAAGGAAACAGC
CAGGTGGATCAAGTTTGAAGAAAAAGTGGAACAGGGTGGGGAAAGATGGAGCAAGCCCCATGTGGCCACATTGTCCCTTCATAGTTTATT
TGAGCTGAGGACATGTATGGAGAAAGGATCCATCATGCTTGATCGGGAGGCTTCTTCTCTCCCACAGTTGGTGGAGATGATTGTTGACCA
TCAGATTGAGACAGGCCTATTGAAACCTGAACTTAAGGATAAGGTGACCTATACTTTGCTCCGGAAGCACCGGCATCAAACCAAGAAATC
CAACCTTCGGTCCCTGGCTGACATTGGGAAGACAGTCTCCAGTGCAAGTAGGATGTTTACCAACCCTGATAATGGTAGCCCAGCCATGAC
CCATAGGAATCTGACTTCCTCCAGTCTGAATGACATTTCTGATAAACCGGAGAAGGACCAGCTGAAGAATAAGTTCATGAAAAAATTGCC
ACGTGATGCAGAAGCTTCCAACGTGCTTGTTGGGGAGGTTGACTTTTTGGATACTCCTTTCATTGCCTTTGTTAGGCTACAGCAGGCTGT
CATGCTGGGTGCCCTGACTGAAGTTCCTGTGCCCACAAGGTTCTTGTTCATTCTCTTAGGTCCTAAGGGGAAAGCCAAGTCCTACCACGA
GATTGGCAGAGCCATTGCCACCCTGATGTCTGATGAGGTGTTCCATGACATTGCTTATAAAGCAAAAGACAGGCACGACCTGATTGCTGG
TATTGATGAGTTCCTAGATGAAGTCATCGTCCTTCCACCTGGGGAATGGGATCCAGCAATTAGGATAGAGCCTCCTAAGAGTCTTCCATC
CTCTGACAAAAGAAAGAATATGTACTCAGGTGGAGAGAATGTTCAGATGAATGGGGATACGCCCCATGATGGAGGTCACGGAGGAGGAGG
ACATGGGGATTGTGAAGAATTGCAGCGAACTGGACGGTTCTGTGGTGGACTAATTAAAGACATAAAGAGGAAAGCGCCATTTTTTGCCAG
TGATTTTTATGATGCTTTAAATATTCAAGCTCTTTCGGCAATTCTCTTCATTTATCTGGCAACTGTAACTAATGCTATCACTTTTGGAGG
ACTGCTTGGGGATGCCACTGACAACATGCAGGGCGTGTTGGAGAGTTTCCTGGGCACTGCTGTCTCTGGAGCCATCTTTTGCCTTTTTGC
TGGTCAACCACTCACTATTCTGAGCAGCACCGGACCTGTCCTAGTTTTTGAGAGGCTTCTATTTAATTTCAGCAAGGACAATAATTTTGA
CTATTTGGAGTTTCGCCTTTGGATTGGCCTGTGGTCCGCCTTCCTATGTCTCATTTTGGTAGCCACTGATGCCAGCTTCTTGGTTCAATA
CTTCACACGTTTCACGGAGGAGGGCTTTTCCTCTCTGATTAGCTTCATCTTTATCTATGATGCTTTCAAGAAGATGATCAAGCTTGCAGA
TTACTACCCCATCAACTCCAACTTCAAAGTGGGCTACAACACTCTCTTTTCCTGTACCTGTGTGCCACCTGACCCAGCTAATATCTCAAT
ATCTAATGACACCACACTGGCCCCAGAGTATTTGCCAACTATGTCTTCTACTGACATGTACCATAATACTACCTTTGACTGGGCATTTTT
GTCGAAGAAGGAGTGTTCAAAATACGGAGGAAACCTCGTCGGGAACAACTGTAATTTTGTTCCTGATATCACACTCATGTCTTTTATCCT
CTTCTTGGGAACCTACACCTCTTCCATGGCTCTGAAAAAATTCAAAACTAGTCCTTATTTTCCAACCACAGCAAGAAAACTGATCAGTGA
TTTTGCCATTATCTTGTCCATTCTCATCTTTTGTGTAATAGATGCCCTAGTAGGCGTGGACACCCCAAAACTAATTGTGCCAAGTGAGTT
CAAGCCAACAAGTCCAAACCGAGGTTGGTTCGTTCCACCGTTTGGAGAAAACCCCTGGTGGGTGTGCCTTGCTGCTGCTATCCCGGCTTT
GTTGGTCACTATACTGATTTTCATGGACCAACAAATTACAGCTGTGATTGTAAACAGGAAAGAACATAAACTCAAGAAAGGAGCAGGGTA
TCACTTGGATCTCTTTTGGGTGGCCATCCTCATGGTTATATGCTCCCTCATGGCTCTTCCGTGGTATGTAGCTGCTACGGTCATCTCCAT
TGCTCACATCGACAGTTTGAAGATGGAGACAGAGACTTCTGCACCTGGAGAACAACCAAAGTTTCTAGGAGTGAGGGAACAAAGAGTCAC
TGGAACCCTTGTGTTTATTCTGACTGGTCTGTCAGTCTTTATGGCTCCCATCTTGAAGACCATGGCAAAAGTTATAACCACCGTACTGAA
GTTCCCTGATGATCAGACTCAGAAAATTTTGGAAAGAGAAGATGCTCGGCTGATGTTTACTTCACCTCGCAGTGGTATCTTCTGAGTAAA
CCATCAGTCTGTGCTTAGTTAACATGTGTCATGGCTCCGATCTTCATCTTGAAGAAGAGTGACATTGGGTGACTGCTGCTTGGAAAACTG
TCCACACTTGCTACTCTTTGAGAATGAAGTTGTCATTCAGGGCCCCTCATGTAGCCAAAAGACCAAGAAAAATCTGGCCCACAGATAAGT
TGCAGACTGCCTTTAAAATAGATTTTATCAGTGGAGAAATGGTGATAGTTTTTTCTTCAGTTTTCTCTTGGGAAGAGTTTTATGTTGTTT
AAAAGATATTTTGATAACTTAACCTGCTTTATGGGCTTACATAATATTCCTTTCATCCATTCTTTTTAAAGAACGGCTTACCTTTCCTAT
TTATTTTTAGGGTGATTTTTTAAAAAGACTTGTGCAATACATTTTGAGGTGAAACTTAGTGGATTTTTTCTGATAAATTAGAGCATTTAA
TTGACTATTTTATTCAGGTTGATCTGTTGAATATTTGCTAAAGACCAGTTCTTTAAGCTAAGACATGTAAAAAATCCCAAATGGCAGTAC
CTCATTGTTTACTTAGCTTTTGTACTTATATTTTTCAGAGGAAAAAACACTACTGTAAATTGTGAATAGCCAATACATAACTGTATTGTA

>In-frame_ENST00000340595_ENST00000361924_TCGA-VP-A875-01A_SLC4A4_chr4_72413437_+_GOLGA4_chr3_37396592_length(amino acids)=899AA_start in transcript=175_stop in transcript=2874
MGGLAGKMSTENVEGKPSNLGERGRARSSTFLRVVQPMFNHSIFTSAVSPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKE
TARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRHQTK
KSNLRSLADIGKTVSSASRMFTNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQ
AVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPAIRIEPPKSL
PSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITF
GGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLV
QYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAPEYLPTMSSTDMYHNTTFDWA
FLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMALKKFKTSPYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPS
EFKPTSPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMALPWYVAATVI

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Fusion Gene PPI Analysis for SLC4A4-GOLGA4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000264485+2026748_779898.01684.6666666666667CA4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000340595+1723748_779854.02318.3333333333335CA4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000425175+2025748_779898.01095.0CA4


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000351898+124748_77901194.6666666666667CA4
HgeneSLC4A4chr4:72413437chr3:37396592ENST00000512686+111748_7790647.0CA4
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003568472023133_2032207.02244.0MACF1
TgeneGOLGA4chr4:72413437chr3:37396592ENST000003619242024133_2032192.02306.3333333333335MACF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC4A4-GOLGA4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC4A4-GOLGA4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC4A4C1970309Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneSLC4A4C0001126Renal tubular acidosis1CTD_human
HgeneSLC4A4C0008073Developmental Disabilities1CTD_human
HgeneSLC4A4C0010038Corneal Opacity1CTD_human
HgeneSLC4A4C0017601Glaucoma1CTD_human
HgeneSLC4A4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC4A4C0085996Child Development Deviations1CTD_human
HgeneSLC4A4C0085997Child Development Disorders, Specific1CTD_human
HgeneSLC4A4C0086543Cataract1CTD_human
HgeneSLC4A4C0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneSLC4A4C0268435Renal Tubular Acidosis, Type II1CTD_human
HgeneSLC4A4C0524524Pseudoaphakia1CTD_human
HgeneSLC4A4C1510497Lens Opacities1CTD_human
HgeneSLC4A4C1704380Distal Renal Tubular Acidosis1CTD_human
TgeneGOLGA4C0033578Prostatic Neoplasms1CTD_human
TgeneGOLGA4C0037274Dermatologic disorders1CTD_human
TgeneGOLGA4C0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneGOLGA4C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneGOLGA4C0311375Arsenic Poisoning1CTD_human
TgeneGOLGA4C0376358Malignant neoplasm of prostate1CTD_human
TgeneGOLGA4C0751851Arsenic Encephalopathy1CTD_human
TgeneGOLGA4C0751852Arsenic Induced Polyneuropathy1CTD_human