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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC4A7-SLC4A7 (FusionGDB2 ID:82812)

Fusion Gene Summary for SLC4A7-SLC4A7

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC4A7-SLC4A7
Fusion gene ID: 82812
HgeneTgene
Gene symbol

SLC4A7

SLC4A7

Gene ID

9497

9497

Gene namesolute carrier family 4 member 7solute carrier family 4 member 7
SynonymsNBC2|NBC3|NBCN1|SBC2|SLC4A6NBC2|NBC3|NBCN1|SBC2|SLC4A6
Cytomap

3p24.1

3p24.1

Type of geneprotein-codingprotein-coding
Descriptionsodium bicarbonate cotransporter 3bicarbonate transporterelectroneutral Na/HCO(3) cotransportersodium bicarbonate cotransporter 2sodium bicarbonate cotransporter 2bsolute carrier family 4, sodium bicarbonate cotransporter, member 7sodium bicarbonate cotransporter 3bicarbonate transporterelectroneutral Na/HCO(3) cotransportersodium bicarbonate cotransporter 2sodium bicarbonate cotransporter 2bsolute carrier family 4, sodium bicarbonate cotransporter, member 7
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000435667, ENST00000440156, 
ENST00000455077, ENST00000437179, 
ENST00000388777, ENST00000454389, 
ENST00000446700, ENST00000425128, 
ENST00000445684, ENST00000428386, 
ENST00000295736, 		ENST00000435667, 
ENST00000440156, ENST00000455077, 
ENST00000437179, ENST00000388777, 
ENST00000454389, ENST00000446700, 
ENST00000425128, ENST00000445684, 
ENST00000428386, ENST00000295736, 
Fusion gene scores* DoF score4 X 5 X 2=404 X 4 X 2=32
# samples 54
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC4A7 [Title/Abstract] AND SLC4A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC4A7(27478997)-SLC4A7(27478932), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC4A7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC4A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA216661SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
ChiTaRS5.0N/AAB012130SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
ChiTaRS5.0N/AAF053755SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-


Top

Fusion Gene ORF analysis for SLC4A7-SLC4A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000435667ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000435667ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000435667ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000435667ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000435667ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000440156ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000440156ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000440156ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000440156ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000440156ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000455077ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000455077ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000455077ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000455077ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000455077ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000437179ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000437179ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000437179ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000437179ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000437179ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000388777ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000388777ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000388777ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000388777ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000388777ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000454389ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000454389ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000454389ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000454389ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000454389ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000446700ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000446700ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000446700ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000446700ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000446700ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000425128ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000425128ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000425128ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000425128ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000425128ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000445684ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000445684ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000445684ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000445684ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000445684ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000428386ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000428386ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000428386ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000428386ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000428386ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000295736ENST00000435667SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000295736ENST00000440156SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000295736ENST00000455077SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-3CDSENST00000295736ENST00000437179SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000388777SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000454389SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000446700SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000425128SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000445684SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000428386SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-
intron-5UTRENST00000295736ENST00000295736SLC4A7chr3

27478997

+SLC4A7chr3

27478932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC4A7-SLC4A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SLC4A7-SLC4A7


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC4A7-SLC4A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC4A7-SLC4A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC4A7-SLC4A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC4A7-SLC4A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC4A7C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneSLC4A7C0152013Adenocarcinoma of lung (disorder)1CTD_human