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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC7A5-ANP32A (FusionGDB2 ID:82903)

Fusion Gene Summary for SLC7A5-ANP32A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC7A5-ANP32A
Fusion gene ID: 82903
HgeneTgene
Gene symbol

SLC7A5

ANP32A

Gene ID

8140

8125

Gene namesolute carrier family 7 member 5acidic nuclear phosphoprotein 32 family member A
Synonyms4F2LC|CD98|D16S469E|E16|LAT1|MPE16C15orf1|HPPCn|I1PP2A|LANP|MAPM|PHAP1|PHAPI|PP32
Cytomap

16q24.2

15q23

Type of geneprotein-codingprotein-coding
Descriptionlarge neutral amino acids transporter small subunit 14F2 light chainCD98 light chainL-type amino acid transporter 1integral membrane protein E16sodium-independent neutral amino acid transporter LAT1solute carrier family 7 (amino acid transporter ligacidic leucine-rich nuclear phosphoprotein 32 family member Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member Aacidic nuclear phosphoprotein pp32cerebellar leucine rich acidic nuclear proteinepididymis secretory sperm binding proteinhep
Modification date2020031320200313
UniProtAcc.

P39687

Ensembl transtripts involved in fusion geneENST00000565644, ENST00000261622, 
ENST00000465139, ENST00000483551, 
ENST00000560303, 
Fusion gene scores* DoF score17 X 9 X 10=15303 X 3 X 3=27
# samples 203
** MAII scorelog2(20/1530*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC7A5 [Title/Abstract] AND ANP32A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC7A5(87902491)-ANP32A(69080258), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC7A5

GO:1904556

L-tryptophan transmembrane transport

30867591

TgeneANP32A

GO:0006913

nucleocytoplasmic transport

11729309


check buttonFusion gene breakpoints across SLC7A5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ANP32A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01ASLC7A5chr16

87902491

-ANP32Achr15

69080258

-


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Fusion Gene ORF analysis for SLC7A5-ANP32A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000565644ENST00000465139SLC7A5chr16

87902491

-ANP32Achr15

69080258

-
intron-5UTRENST00000565644ENST00000483551SLC7A5chr16

87902491

-ANP32Achr15

69080258

-
intron-5UTRENST00000565644ENST00000560303SLC7A5chr16

87902491

-ANP32Achr15

69080258

-
In-frameENST00000261622ENST00000465139SLC7A5chr16

87902491

-ANP32Achr15

69080258

-
5CDS-5UTRENST00000261622ENST00000483551SLC7A5chr16

87902491

-ANP32Achr15

69080258

-
5CDS-5UTRENST00000261622ENST00000560303SLC7A5chr16

87902491

-ANP32Achr15

69080258

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261622SLC7A5chr1687902491-ENST00000465139ANP32Achr1569080258-28466046191299226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261622ENST00000465139SLC7A5chr1687902491-ANP32Achr1569080258-0.0008994220.99910057

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Fusion Genomic Features for SLC7A5-ANP32A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC7A5-ANP32A


check button Go to

FGviewer for the breakpoints of chr16:87902491-chr15:69080258

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANP32A

P39687

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:16341127, PubMed:11360199, PubMed:18439902, PubMed:10400610). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114). {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:11830591, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:16341127, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:18180367, ECO:0000269|PubMed:18439902}.; FUNCTION: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:32694517, PubMed:33045004, PubMed:33208942, PubMed:30666459). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Plays also an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877). {ECO:0000269|PubMed:21159877, ECO:0000269|PubMed:30666459, ECO:0000269|PubMed:32694517, ECO:0000269|PubMed:33045004, ECO:0000269|PubMed:33208942}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110105_126179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110148_169179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-1101_49179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11071_83179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110127_147179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11050_70179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-11084_104179.33333333333334508.0TransmembraneHelical
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907168_24918.0250.0Compositional biasNote=Asp/Glu-rich (highly acidic)
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907123_16118.0250.0DomainNote=LRRCT
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907150_17418.0250.0RegionNote=Necessary for tumor-suppressive function
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390718_3818.0250.0RepeatLRR 1
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390743_6418.0250.0RepeatLRR 2
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390765_8718.0250.0RepeatLRR 3
TgeneANP32Achr16:87902491chr15:69080258ENST000004651390789_11018.0250.0RepeatLRR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110191_192179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110215_242179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110264_276179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110298_324179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110346_369179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110391_395179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110417_430179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110452_457179.33333333333334508.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110479_507179.33333333333334508.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110105_1260242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110148_1690242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110191_1920242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-1101_490242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110215_2420242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110264_2760242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110298_3240242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110346_3690242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110391_3950242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110417_4300242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110452_4570242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110479_5070242.0Topological domainCytoplasmic
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11071_830242.0Topological domainExtracellular
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110170_190179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110193_214179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110243_263179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110277_297179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110325_345179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110370_390179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110396_416179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110431_451179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000261622-110458_478179.33333333333334508.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110127_1470242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110170_1900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110193_2140242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110243_2630242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110277_2970242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110325_3450242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110370_3900242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110396_4160242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110431_4510242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-110458_4780242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11050_700242.0TransmembraneHelical
HgeneSLC7A5chr16:87902491chr15:69080258ENST00000565644-11084_1040242.0TransmembraneHelical


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Fusion Gene Sequence for SLC7A5-ANP32A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000261622_ENST00000465139_TCGA-CG-5721-01A_SLC7A5_chr16_87902491_-_ANP32A_chr15_69080258_length(transcript)=2846nt_BP=604nt
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCGCAGAGCATGGCGGGTGCGGGCCCGAAGCGG
CGCGCGCTAGCGGCGCCGGCGGCCGAGGAGAAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA
GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATCATCGTGGGGACCATTATCGGCTCGGGCATC
TTCGTGACGCCCACGGGCGTGCTCAAGGAGGCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG
GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCCTACATGCTGGAGGTCTACGGCTCGCTGCCC
GCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG
CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGCGTGCGTGAAAGAACTTGTCCTGGACAACAG
TCGGTCGAATGAAGGCAAACTCGAAGGCCTCACAGATGAATTTGAAGAACTGGAATTCTTAAGTACAATCAACGTAGGCCTCACCTCAAT
CGCAAACTTACCAAAGTTAAACAAACTTAAGAAGCTTGAACTAAGCGATAACAGAGTCTCAGGGGGCCTGGAAGTATTGGCAGAAAAGTG
TCCGAACCTCACGCATCTAAATTTAAGTGGCAACAAAATTAAAGACCTCAGCACAATAGAGCCACTGAAAAAGTTAGAAAACCTCAAGAG
CTTAGACCTTTTCAATTGCGAGGTAACCAACCTGAACGACTACCGAGAAAATGTGTTCAAGCTCCTCCCGCAACTCACATATCTCGACGG
CTATGACCGGGACGACAAGGAGGCCCCTGACTCGGATGCTGAGGGCTACGTGGAGGGCCTGGATGATGAGGAGGAGGATGAGGATGAGGA
GGAGTATGATGAAGATGCTCAGGTAGTGGAAGACGAGGAGGACGAGGATGAGGAGGAGGAAGGTGAAGAGGAGGACGTGAGTGGAGAGGA
GGAGGAGGATGAAGAAGGTTATAACGATGGAGAGGTAGATGACGAGGAAGATGAAGAAGAGCTTGGTGAAGAAGAAAGGGGTCAGAAGCG
AAAACGAGAACCTGAAGATGAGGGAGAAGATGATGACTAAGTGGAATAACCTATTTTGAAAAATTCCTATTGTGATTTGACTGTTTTTAC
CCATATCCCCTCTCCCCCCCCCCTCCAATCCTGCCCCCTGAAACTTATTTTTTTCTGATTGTAACGTTGCTGTGGGAACGAGAGGGGAAG
AGTGTACTGGGGGTTGCGGGGGGAGGGATGGCGGGTGGGGGTGGAATAAAATACTATTTTTACTGCCACTCTTTATTTTTTTCCCCTACT
TTTTCTTTGTGTCCGGTTTTTGTCCCTGTAAATGCGATAGCTAAGTACACACTAAGTGAGCATTTGTTCCTGACTCTCAAAGAGGATGGT
TTGGAGTTCTCTTACGTTTCCTGGTATTTCCCAAGTCTCTTGGGTTGGTTGGAAGGCTGTGGCTGGTCTCAGTTTGGTTACTCAATGCCC
AGGAGGGGCTGAGCACCAGCCATATCTTTTGCTTTGGTTCACATGATGATACCTGCTTTTCTCAGGCCTGCTAGAGGCATCCAACGCCCT
GGTTTGTAAATAGCAACCTAAAGGCGTATTTTGGCACTGGTCTGGGGACATTCCCCATCTCTCATCCCTTTTCCCCCTTCACAGATGGTG
GTGGGCTTCGCTCTACAAAGAGGACTCTGATGTTACTCTTGAGCTTATGAGCCAGAGAGCTGAAAACCGCAGGCTTGTTGTGTTAAGTTA
CAAGGAAAATGGATTTGGTAATTAAAATTAGAAGAAACACACCTTCAAACTTCAACTTCTTTAAAAGAAAAAAAAAACTGTCCTATCTTG
TTCTGTAAAATATTAGAACGCTTTGTTTTACAAAAAATGATGAGAGAATTCTTCCACATGTACTTCTGTGCTTAGAACATTTTTACGGAC
CTAAGCGCTGGAGACGTTGCTGCATGTCGGCTGGGTTTTTTTTTTCATACACCCGAGCACGGAAAAACTAACGCAAAATTGTATTTTCTT
ACCTAGTGGAAATCTGAAATGACTGCAAATTCCTAGTGAATGTACAGGTTTGCTTTCGTGTCCCTCTTCTGGTTGCTTTAGAAGTGACGT
GTAATTTCTGAACCCATGTTTCATCTGTATAAAAGAACATCTGCACCAGTTTTTCTCCTGCCCCTCAGAAGAGCCAAACTTTGAGTTTTA
TGTCTGTTTGTCATTGATAAATTTCAATAAATCTTTTTATACAATTTTTTTGGGGATGGCTTCTTTGAGTCCAACAGGCCATTGATCTTT
TCAAGATGCATTCCAGATGAACTGCTAGGTGAGGGGGAAGCTTCATTTTTGTTACCTGATAGAATAGCTTTTCTTATGAGATATATATAA
TGTGATACTATGTTTGGATATTTTTGGTCTTAAAGCAAGACTCAGTGGTGTATCTTCATTAAAAGCTTCCTTTAAAAAAGTTACAGAGTT
ACTAAAAAAACAAGTACCCAAACAATCAAGTTGGGCCAACCTTGGAACCTTGTTTTGAATATCTTTCATTGTTTTGTTTGTCGTATTGTA

>In-frame_ENST00000261622_ENST00000465139_TCGA-CG-5721-01A_SLC7A5_chr16_87902491_-_ANP32A_chr15_69080258_length(amino acids)=226AA_start in transcript=619_stop in transcript=1299
MDNSRSNEGKLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTHLNLSGNKIKDLSTIEPLKKLE
NLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDEEDEDEEEEGEEEDV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SLC7A5-ANP32A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneANP32Achr16:87902491chr15:69080258ENST0000046513907165_24918.0250.0E4F1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC7A5-ANP32A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC7A5-ANP32A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC7A5C0024121Lung Neoplasms1CTD_human
HgeneSLC7A5C0162820Dermatitis, Allergic Contact1CTD_human
HgeneSLC7A5C0242379Malignant neoplasm of lung1CTD_human
TgeneANP32AC0009402Colorectal Carcinoma1CTD_human
TgeneANP32AC0009404Colorectal Neoplasms1CTD_human
TgeneANP32AC0152013Adenocarcinoma of lung (disorder)1CTD_human