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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC9A3R1-FBXO18 (FusionGDB2 ID:82962)

Fusion Gene Summary for SLC9A3R1-FBXO18

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC9A3R1-FBXO18
Fusion gene ID: 82962
HgeneTgene
Gene symbol

SLC9A3R1

FBXO18

Gene ID

9368

84893

Gene nameSLC9A3 regulator 1F-box DNA helicase 1
SynonymsEBP50|NHERF|NHERF-1|NHERF1|NPHLOP2FBXO18|Fbx18|hFBH1
Cytomap

17q25.1

10p15.1

Type of geneprotein-codingprotein-coding
DescriptionNa(+)/H(+) exchange regulatory cofactor NHE-RF1Na+/H+ exchange regulatory co-factorezrin-radixin-moesin binding phosphoprotein-50regulatory cofactor of Na(+)/H(+) exchangersolute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factoF-box DNA helicase 1F-box only protein, helicase, 18F-box protein, helicase, 18
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262613, ENST00000413388, 
ENST00000397269, ENST00000362091, 
ENST00000470089, ENST00000379999, 
Fusion gene scores* DoF score7 X 8 X 6=3366 X 5 X 5=150
# samples 107
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/150*10)=-1.09953567355091
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC9A3R1 [Title/Abstract] AND FBXO18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC9A3R1(72745426)-FBXO18(5978419), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC9A3R1

GO:0008285

negative regulation of cell proliferation

20012548

HgeneSLC9A3R1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

20012548

HgeneSLC9A3R1

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

20012548

TgeneFBXO18

GO:0006974

cellular response to DNA damage stimulus

19736316|23319600|23361013|25585578

TgeneFBXO18

GO:0008219

cell death

23319600

TgeneFBXO18

GO:0016567

protein ubiquitination

25585578

TgeneFBXO18

GO:0031297

replication fork processing

25585578

TgeneFBXO18

GO:2000042

negative regulation of double-strand break repair via homologous recombination

19736316


check buttonFusion gene breakpoints across SLC9A3R1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXO18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-7318-01BSLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
ChimerDB4PRADTCGA-EJ-7318SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
ChimerDB4PRADTCGA-EJ-7318SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
ChimerDB4PRADTCGA-EJ-7318SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
ChimerDB4PRADTCGA-EJ-7318-01BSLC9A3R1chr17

72745426

-FBXO18chr10

5978419

+


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Fusion Gene ORF analysis for SLC9A3R1-FBXO18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262613ENST00000397269SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
In-frameENST00000262613ENST00000362091SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
5CDS-intronENST00000262613ENST00000470089SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
5CDS-intronENST00000262613ENST00000379999SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
intron-3CDSENST00000413388ENST00000397269SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
intron-3CDSENST00000413388ENST00000362091SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
intron-intronENST00000413388ENST00000470089SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
intron-intronENST00000413388ENST00000379999SLC9A3R1chr17

72745426

+FBXO18chr10

5978419

+
In-frameENST00000262613ENST00000397269SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
In-frameENST00000262613ENST00000362091SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
5CDS-intronENST00000262613ENST00000470089SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
5CDS-intronENST00000262613ENST00000379999SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
intron-3CDSENST00000413388ENST00000397269SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
intron-3CDSENST00000413388ENST00000362091SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
intron-intronENST00000413388ENST00000470089SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+
intron-intronENST00000413388ENST00000379999SLC9A3R1chr17

72745426

+FBXO18chr10

5978418

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262613SLC9A3R1chr1772745426+ENST00000397269FBXO18chr105978419+124563666938290
ENST00000262613SLC9A3R1chr1772745426+ENST00000362091FBXO18chr105978419+125263666938290
ENST00000262613SLC9A3R1chr1772745426+ENST00000397269FBXO18chr105978418+124563666938290
ENST00000262613SLC9A3R1chr1772745426+ENST00000362091FBXO18chr105978418+125263666938290

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262613ENST00000397269SLC9A3R1chr1772745426+FBXO18chr105978419+0.0059586450.9940414
ENST00000262613ENST00000362091SLC9A3R1chr1772745426+FBXO18chr105978419+0.0057698950.99423015
ENST00000262613ENST00000397269SLC9A3R1chr1772745426+FBXO18chr105978418+0.0059586450.9940414
ENST00000262613ENST00000362091SLC9A3R1chr1772745426+FBXO18chr105978418+0.0057698950.99423015

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Fusion Genomic Features for SLC9A3R1-FBXO18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC9A3R1chr1772745426+FBXO18chr105978418+4.92E-141
SLC9A3R1chr1772745426+FBXO18chr105978418+4.92E-141
SLC9A3R1chr1772745426+FBXO18chr105978418+4.92E-141
SLC9A3R1chr1772745426+FBXO18chr105978418+4.92E-141

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SLC9A3R1-FBXO18


check button Go to

FGviewer for the breakpoints of chr17:72745426-chr10:5978419

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC9A3R1chr17:72745426chr10:5978418ENST00000262613+1614_94147.0359.0DomainPDZ 1
HgeneSLC9A3R1chr17:72745426chr10:5978419ENST00000262613+1614_94147.0359.0DomainPDZ 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC9A3R1chr17:72745426chr10:5978418ENST00000262613+16154_234147.0359.0DomainPDZ 2
HgeneSLC9A3R1chr17:72745426chr10:5978419ENST00000262613+16154_234147.0359.0DomainPDZ 2
TgeneFBXO18chr17:72745426chr10:5978418ENST000003620911821138_184943.01044.0DomainF-box
TgeneFBXO18chr17:72745426chr10:5978418ENST000003620911821442_705943.01044.0DomainUvrD-like helicase ATP-binding
TgeneFBXO18chr17:72745426chr10:5978418ENST000003799991922138_184994.01095.0DomainF-box
TgeneFBXO18chr17:72745426chr10:5978418ENST000003799991922442_705994.01095.0DomainUvrD-like helicase ATP-binding
TgeneFBXO18chr17:72745426chr10:5978419ENST000003620911821138_184943.01044.0DomainF-box
TgeneFBXO18chr17:72745426chr10:5978419ENST000003620911821442_705943.01044.0DomainUvrD-like helicase ATP-binding
TgeneFBXO18chr17:72745426chr10:5978419ENST000003799991922138_184994.01095.0DomainF-box
TgeneFBXO18chr17:72745426chr10:5978419ENST000003799991922442_705994.01095.0DomainUvrD-like helicase ATP-binding
TgeneFBXO18chr17:72745426chr10:5978418ENST00000362091182157_64943.01044.0MotifPIP-box
TgeneFBXO18chr17:72745426chr10:5978418ENST000003620911821807_811943.01044.0MotifAPIM motif
TgeneFBXO18chr17:72745426chr10:5978418ENST00000379999192257_64994.01095.0MotifPIP-box
TgeneFBXO18chr17:72745426chr10:5978418ENST000003799991922807_811994.01095.0MotifAPIM motif
TgeneFBXO18chr17:72745426chr10:5978419ENST00000362091182157_64943.01044.0MotifPIP-box
TgeneFBXO18chr17:72745426chr10:5978419ENST000003620911821807_811943.01044.0MotifAPIM motif
TgeneFBXO18chr17:72745426chr10:5978419ENST00000379999192257_64994.01095.0MotifPIP-box
TgeneFBXO18chr17:72745426chr10:5978419ENST000003799991922807_811994.01095.0MotifAPIM motif
TgeneFBXO18chr17:72745426chr10:5978418ENST000003620911821463_470943.01044.0Nucleotide bindingATP
TgeneFBXO18chr17:72745426chr10:5978418ENST000003799991922463_470994.01095.0Nucleotide bindingATP
TgeneFBXO18chr17:72745426chr10:5978419ENST000003620911821463_470943.01044.0Nucleotide bindingATP
TgeneFBXO18chr17:72745426chr10:5978419ENST000003799991922463_470994.01095.0Nucleotide bindingATP


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Fusion Gene Sequence for SLC9A3R1-FBXO18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262613_ENST00000397269_TCGA-EJ-7318-01B_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978419_length(transcript)=1245nt_BP=636nt
GTCTGTGGTCCTCTCTCGGCTCCTCGCGGCTCGCGGCGGCCGACGGTTCCTGGGACACCTGCTTGCTTGGCCCGTCCGGCGGCTCAGGGC
TTCTCTGCTGCGCTCCCGGTTCGCTGGACGGGAAGAAGGGCTGGGCCGTCCCGTCCCGTCCCCATCGGAACCCCAAGTCGCGCCGCTGAC
CCGTCGCAGGGCGAGATGAGCGCGGACGCAGCGGCCGGGGCGCCCCTGCCCCGGCTCTGCTGCCTGGAGAAGGGTCCGAACGGCTACGGC
TTCCACCTGCACGGGGAGAAGGGCAAGTTGGGCCAGTACATCCGGCTGGTGGAGCCCGGCTCGCCGGCCGAGAAGGCGGGGCTGCTGGCG
GGGGACCGGCTGGTGGAGGTGAACGGCGAAAACGTGGAGAAGGAGACCCACCAGCAGGTGGTGAGCCGCATCCGCGCCGCACTCAACGCC
GTGCGCCTGCTGGTGGTCGACCCCGAGACGGACGAGCAGCTGCAGAAGCTCGGCGTCCAGGTCCGAGAGGAGCTGCTGCGCGCCCAGGAA
GCGCCGGGGCAGGCCGAGCCGCCGGCCGCCGCCGAGGTGCAGGGGGCTGGCAACGAAAATGAGCCTCGCGAGGCCGACAAGAGCCACCCG
GAGCAGGAGTACTTCTTGCAAGCAGAGCTGACAAGCAACGTCTTAAAAACAGGCGTGGTGCGCTGCTGCGTGGGACAGTGCAACAATGCC
ATCCCTGTTGACACCGTCCTTACCATGAAGAAGCTGCCCATCACCTATAGCAACAGGAAGGAAAACAAGGGGGGCTACCTCTGCCACTCC
TGTGCGGAGCAGCGCATCGGGCCCCTGGCGTTCCTGACAGCCTCCCCGGAGCAGGTGCGCGCCATGGAGCGCACTGTGGAGAACATCGTA
CTGCCCCGGCATGAGGCCCTGCTCTTCCTCGTCTTCTGAGGACAAGGCGCACGTTCTCCGCAGTGCAGAGCAGCTTGCCGAGGACCCCGC
GTGAAGAAAGCCAGCGAGGGGGGCTTCTGCTCCCTGAGACTCTGGGTTCACCCACAGCACTTTCTGAGGAAGAGGACACCAGCCCAAGCT
GGACCTGCCATTTCTCCACTCCCTACAGACAGCCAGTCTCCACTTGCCTCCCCTCTGGATGTATCTGGTCAGGGAAGTGGGGGATGTTCT

>In-frame_ENST00000262613_ENST00000397269_TCGA-EJ-7318-01B_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978419_length(amino acids)=290AA_start in transcript=66_stop in transcript=938
MARPAAQGFSAALPVRWTGRRAGPSRPVPIGTPSRAADPSQGEMSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSP
AEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEP
READKSHPEQEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAM

--------------------------------------------------------------
>In-frame_ENST00000262613_ENST00000362091_TCGA-EJ-7318-01B_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978419_length(transcript)=1252nt_BP=636nt
GTCTGTGGTCCTCTCTCGGCTCCTCGCGGCTCGCGGCGGCCGACGGTTCCTGGGACACCTGCTTGCTTGGCCCGTCCGGCGGCTCAGGGC
TTCTCTGCTGCGCTCCCGGTTCGCTGGACGGGAAGAAGGGCTGGGCCGTCCCGTCCCGTCCCCATCGGAACCCCAAGTCGCGCCGCTGAC
CCGTCGCAGGGCGAGATGAGCGCGGACGCAGCGGCCGGGGCGCCCCTGCCCCGGCTCTGCTGCCTGGAGAAGGGTCCGAACGGCTACGGC
TTCCACCTGCACGGGGAGAAGGGCAAGTTGGGCCAGTACATCCGGCTGGTGGAGCCCGGCTCGCCGGCCGAGAAGGCGGGGCTGCTGGCG
GGGGACCGGCTGGTGGAGGTGAACGGCGAAAACGTGGAGAAGGAGACCCACCAGCAGGTGGTGAGCCGCATCCGCGCCGCACTCAACGCC
GTGCGCCTGCTGGTGGTCGACCCCGAGACGGACGAGCAGCTGCAGAAGCTCGGCGTCCAGGTCCGAGAGGAGCTGCTGCGCGCCCAGGAA
GCGCCGGGGCAGGCCGAGCCGCCGGCCGCCGCCGAGGTGCAGGGGGCTGGCAACGAAAATGAGCCTCGCGAGGCCGACAAGAGCCACCCG
GAGCAGGAGTACTTCTTGCAAGCAGAGCTGACAAGCAACGTCTTAAAAACAGGCGTGGTGCGCTGCTGCGTGGGACAGTGCAACAATGCC
ATCCCTGTTGACACCGTCCTTACCATGAAGAAGCTGCCCATCACCTATAGCAACAGGAAGGAAAACAAGGGGGGCTACCTCTGCCACTCC
TGTGCGGAGCAGCGCATCGGGCCCCTGGCGTTCCTGACAGCCTCCCCGGAGCAGGTGCGCGCCATGGAGCGCACTGTGGAGAACATCGTA
CTGCCCCGGCATGAGGCCCTGCTCTTCCTCGTCTTCTGAGGACAAGGCGCACGTTCTCCGCAGTGCAGAGCAGCTTGCCGAGGACCCCGC
GTGAAGAAAGCCAGCGAGGGGGGCTTCTGCTCCCTGAGACTCTGGGTTCACCCACAGCACTTTCTGAGGAAGAGGACACCAGCCCAAGCT
GGACCTGCCATTTCTCCACTCCCTACAGACAGCCAGTCTCCACTTGCCTCCCCTCTGGATGTATCTGGTCAGGGAAGTGGGGGATGTTCT

>In-frame_ENST00000262613_ENST00000362091_TCGA-EJ-7318-01B_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978419_length(amino acids)=290AA_start in transcript=66_stop in transcript=938
MARPAAQGFSAALPVRWTGRRAGPSRPVPIGTPSRAADPSQGEMSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSP
AEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEP
READKSHPEQEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAM

--------------------------------------------------------------
>In-frame_ENST00000262613_ENST00000397269_TCGA-EJ-7318_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978418_length(transcript)=1245nt_BP=636nt
GTCTGTGGTCCTCTCTCGGCTCCTCGCGGCTCGCGGCGGCCGACGGTTCCTGGGACACCTGCTTGCTTGGCCCGTCCGGCGGCTCAGGGC
TTCTCTGCTGCGCTCCCGGTTCGCTGGACGGGAAGAAGGGCTGGGCCGTCCCGTCCCGTCCCCATCGGAACCCCAAGTCGCGCCGCTGAC
CCGTCGCAGGGCGAGATGAGCGCGGACGCAGCGGCCGGGGCGCCCCTGCCCCGGCTCTGCTGCCTGGAGAAGGGTCCGAACGGCTACGGC
TTCCACCTGCACGGGGAGAAGGGCAAGTTGGGCCAGTACATCCGGCTGGTGGAGCCCGGCTCGCCGGCCGAGAAGGCGGGGCTGCTGGCG
GGGGACCGGCTGGTGGAGGTGAACGGCGAAAACGTGGAGAAGGAGACCCACCAGCAGGTGGTGAGCCGCATCCGCGCCGCACTCAACGCC
GTGCGCCTGCTGGTGGTCGACCCCGAGACGGACGAGCAGCTGCAGAAGCTCGGCGTCCAGGTCCGAGAGGAGCTGCTGCGCGCCCAGGAA
GCGCCGGGGCAGGCCGAGCCGCCGGCCGCCGCCGAGGTGCAGGGGGCTGGCAACGAAAATGAGCCTCGCGAGGCCGACAAGAGCCACCCG
GAGCAGGAGTACTTCTTGCAAGCAGAGCTGACAAGCAACGTCTTAAAAACAGGCGTGGTGCGCTGCTGCGTGGGACAGTGCAACAATGCC
ATCCCTGTTGACACCGTCCTTACCATGAAGAAGCTGCCCATCACCTATAGCAACAGGAAGGAAAACAAGGGGGGCTACCTCTGCCACTCC
TGTGCGGAGCAGCGCATCGGGCCCCTGGCGTTCCTGACAGCCTCCCCGGAGCAGGTGCGCGCCATGGAGCGCACTGTGGAGAACATCGTA
CTGCCCCGGCATGAGGCCCTGCTCTTCCTCGTCTTCTGAGGACAAGGCGCACGTTCTCCGCAGTGCAGAGCAGCTTGCCGAGGACCCCGC
GTGAAGAAAGCCAGCGAGGGGGGCTTCTGCTCCCTGAGACTCTGGGTTCACCCACAGCACTTTCTGAGGAAGAGGACACCAGCCCAAGCT
GGACCTGCCATTTCTCCACTCCCTACAGACAGCCAGTCTCCACTTGCCTCCCCTCTGGATGTATCTGGTCAGGGAAGTGGGGGATGTTCT

>In-frame_ENST00000262613_ENST00000397269_TCGA-EJ-7318_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978418_length(amino acids)=290AA_start in transcript=66_stop in transcript=938
MARPAAQGFSAALPVRWTGRRAGPSRPVPIGTPSRAADPSQGEMSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSP
AEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEP
READKSHPEQEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAM

--------------------------------------------------------------
>In-frame_ENST00000262613_ENST00000362091_TCGA-EJ-7318_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978418_length(transcript)=1252nt_BP=636nt
GTCTGTGGTCCTCTCTCGGCTCCTCGCGGCTCGCGGCGGCCGACGGTTCCTGGGACACCTGCTTGCTTGGCCCGTCCGGCGGCTCAGGGC
TTCTCTGCTGCGCTCCCGGTTCGCTGGACGGGAAGAAGGGCTGGGCCGTCCCGTCCCGTCCCCATCGGAACCCCAAGTCGCGCCGCTGAC
CCGTCGCAGGGCGAGATGAGCGCGGACGCAGCGGCCGGGGCGCCCCTGCCCCGGCTCTGCTGCCTGGAGAAGGGTCCGAACGGCTACGGC
TTCCACCTGCACGGGGAGAAGGGCAAGTTGGGCCAGTACATCCGGCTGGTGGAGCCCGGCTCGCCGGCCGAGAAGGCGGGGCTGCTGGCG
GGGGACCGGCTGGTGGAGGTGAACGGCGAAAACGTGGAGAAGGAGACCCACCAGCAGGTGGTGAGCCGCATCCGCGCCGCACTCAACGCC
GTGCGCCTGCTGGTGGTCGACCCCGAGACGGACGAGCAGCTGCAGAAGCTCGGCGTCCAGGTCCGAGAGGAGCTGCTGCGCGCCCAGGAA
GCGCCGGGGCAGGCCGAGCCGCCGGCCGCCGCCGAGGTGCAGGGGGCTGGCAACGAAAATGAGCCTCGCGAGGCCGACAAGAGCCACCCG
GAGCAGGAGTACTTCTTGCAAGCAGAGCTGACAAGCAACGTCTTAAAAACAGGCGTGGTGCGCTGCTGCGTGGGACAGTGCAACAATGCC
ATCCCTGTTGACACCGTCCTTACCATGAAGAAGCTGCCCATCACCTATAGCAACAGGAAGGAAAACAAGGGGGGCTACCTCTGCCACTCC
TGTGCGGAGCAGCGCATCGGGCCCCTGGCGTTCCTGACAGCCTCCCCGGAGCAGGTGCGCGCCATGGAGCGCACTGTGGAGAACATCGTA
CTGCCCCGGCATGAGGCCCTGCTCTTCCTCGTCTTCTGAGGACAAGGCGCACGTTCTCCGCAGTGCAGAGCAGCTTGCCGAGGACCCCGC
GTGAAGAAAGCCAGCGAGGGGGGCTTCTGCTCCCTGAGACTCTGGGTTCACCCACAGCACTTTCTGAGGAAGAGGACACCAGCCCAAGCT
GGACCTGCCATTTCTCCACTCCCTACAGACAGCCAGTCTCCACTTGCCTCCCCTCTGGATGTATCTGGTCAGGGAAGTGGGGGATGTTCT

>In-frame_ENST00000262613_ENST00000362091_TCGA-EJ-7318_SLC9A3R1_chr17_72745426_+_FBXO18_chr10_5978418_length(amino acids)=290AA_start in transcript=66_stop in transcript=938
MARPAAQGFSAALPVRWTGRRAGPSRPVPIGTPSRAADPSQGEMSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSP
AEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEP
READKSHPEQEYFLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPITYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAM

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Fusion Gene PPI Analysis for SLC9A3R1-FBXO18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC9A3R1-FBXO18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC9A3R1-FBXO18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC9A3R1C2676782Nephrolithiasis-Osteoporosis, Hypophosphatemic, 23CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneSLC9A3R1C0021367Mammary Ductal Carcinoma1CTD_human
HgeneSLC9A3R1C1134719Invasive Ductal Breast Carcinoma1CTD_human