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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:SMEK1-IFNGR2 (FusionGDB2 ID:83464) |
Fusion Gene Summary for SMEK1-IFNGR2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SMEK1-IFNGR2 | Fusion gene ID: 83464 | Hgene | Tgene | Gene symbol | SMEK1 | IFNGR2 | Gene ID | 55671 | 3460 |
Gene name | protein phosphatase 4 regulatory subunit 3A | interferon gamma receptor 2 | |
Synonyms | FLFL1|KIAA2010|MSTP033|PP4R3|PP4R3A|SMEK1|smk-1|smk1 | AF-1|IFGR2|IFNGT1|IMD28 | |
Cytomap | 14q32.12 | 21q22.11 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 4 regulatory subunit 3ASMEK homolog 1, suppressor of mek1 | interferon gamma receptor 2IFN-gamma receptor 2IFN-gamma-R-betaIFN-gamma-R2interferon gamma receptor accessory factor-1interferon gamma receptor beta chaininterferon gamma transducer 1 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | P38484 | |
Ensembl transtripts involved in fusion gene | ENST00000554684, ENST00000428424, ENST00000337238, ENST00000554943, ENST00000555462, ENST00000555718, | ENST00000290219, ENST00000381995, ENST00000405436, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 10 X 9 X 8=720 |
# samples | 8 | 11 | |
** MAII score | log2(8/100*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/720*10)=-2.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMEK1 [Title/Abstract] AND IFNGR2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | SMEK1(91947919)-IFNGR2(34804483), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | SMEK1-IFNGR2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SMEK1-IFNGR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene breakpoints across SMEK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across IFNGR2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | 43N | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
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Fusion Gene ORF analysis for SMEK1-IFNGR2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000554684 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
In-frame | ENST00000554684 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
In-frame | ENST00000554684 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000428424 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000428424 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000428424 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
Frame-shift | ENST00000337238 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
Frame-shift | ENST00000337238 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
Frame-shift | ENST00000337238 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
In-frame | ENST00000554943 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
In-frame | ENST00000554943 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
In-frame | ENST00000554943 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555462 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555462 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555462 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555718 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555718 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
intron-3CDS | ENST00000555718 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000554684 | SMEK1 | chr14 | 91947919 | - | ENST00000290219 | IFNGR2 | chr21 | 34804483 | + | 2424 | 1412 | 224 | 1864 | 546 |
ENST00000554684 | SMEK1 | chr14 | 91947919 | - | ENST00000381995 | IFNGR2 | chr21 | 34804483 | + | 2424 | 1412 | 224 | 1864 | 546 |
ENST00000554684 | SMEK1 | chr14 | 91947919 | - | ENST00000405436 | IFNGR2 | chr21 | 34804483 | + | 2405 | 1412 | 224 | 1864 | 546 |
ENST00000554943 | SMEK1 | chr14 | 91947919 | - | ENST00000290219 | IFNGR2 | chr21 | 34804483 | + | 2043 | 1031 | 80 | 1483 | 467 |
ENST00000554943 | SMEK1 | chr14 | 91947919 | - | ENST00000381995 | IFNGR2 | chr21 | 34804483 | + | 2043 | 1031 | 80 | 1483 | 467 |
ENST00000554943 | SMEK1 | chr14 | 91947919 | - | ENST00000405436 | IFNGR2 | chr21 | 34804483 | + | 2024 | 1031 | 80 | 1483 | 467 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000554684 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000472823 | 0.9995272 |
ENST00000554684 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000472823 | 0.9995272 |
ENST00000554684 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000490397 | 0.9995096 |
ENST00000554943 | ENST00000290219 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000320912 | 0.9996791 |
ENST00000554943 | ENST00000381995 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000320912 | 0.9996791 |
ENST00000554943 | ENST00000405436 | SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.000336231 | 0.99966383 |
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Fusion Genomic Features for SMEK1-IFNGR2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.997428 | 0.00257194 |
SMEK1 | chr14 | 91947919 | - | IFNGR2 | chr21 | 34804483 | + | 0.997428 | 0.00257194 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SMEK1-IFNGR2 |
Go to FGviewer for the breakpoints of chr14:91947919-chr21:34804483 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | IFNGR2 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:8124716, PubMed:7673114,PubMed:7615558). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:8124716, PubMed:7673114, PubMed:15356148). Required for signal transduction in contrast to other receptor subunit responsible for ligand binding (PubMed:7673114). {ECO:0000269|PubMed:15356148, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7673114, ECO:0000269|PubMed:8124716}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SMEK1 | chr14:91947919 | chr21:34804483 | ENST00000337238 | - | 5 | 16 | 1_100 | 305.0 | 821.0 | Domain | Note=WH1 |
Hgene | SMEK1 | chr14:91947919 | chr21:34804483 | ENST00000554684 | - | 4 | 15 | 1_100 | 305.0 | 821.0 | Domain | Note=WH1 |
Hgene | SMEK1 | chr14:91947919 | chr21:34804483 | ENST00000554943 | - | 4 | 15 | 1_100 | 305.0 | 834.0 | Domain | Note=WH1 |
Tgene | IFNGR2 | chr14:91947919 | chr21:34804483 | ENST00000290219 | 3 | 7 | 269_337 | 187.0 | 338.0 | Topological domain | Cytoplasmic | |
Tgene | IFNGR2 | chr14:91947919 | chr21:34804483 | ENST00000290219 | 3 | 7 | 248_268 | 187.0 | 338.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SMEK1 | chr14:91947919 | chr21:34804483 | ENST00000428424 | - | 1 | 14 | 1_100 | 0 | 595.0 | Domain | Note=WH1 |
Hgene | SMEK1 | chr14:91947919 | chr21:34804483 | ENST00000555462 | - | 1 | 13 | 1_100 | 0 | 595.0 | Domain | Note=WH1 |
Tgene | IFNGR2 | chr14:91947919 | chr21:34804483 | ENST00000290219 | 3 | 7 | 142_240 | 187.0 | 338.0 | Domain | Fibronectin type-III 2 | |
Tgene | IFNGR2 | chr14:91947919 | chr21:34804483 | ENST00000290219 | 3 | 7 | 31_129 | 187.0 | 338.0 | Domain | Fibronectin type-III 1 | |
Tgene | IFNGR2 | chr14:91947919 | chr21:34804483 | ENST00000290219 | 3 | 7 | 28_247 | 187.0 | 338.0 | Topological domain | Extracellular |
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Fusion Gene Sequence for SMEK1-IFNGR2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000554684_ENST00000290219_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2424nt_BP=1412nt CGCCTGTCGGCTTCTGACGTTTAAAACAGGGGGAGCGGAAGGGAGCCACTGGCCGCGGTGGCAGGGCCAGGTATAAGGAAGGAAAATATG GCGGCGGCGGCGGCGGCCTGAGGAGGCGGCGGCGGCGCGGGAAGCTGCTTCGCGGAGATCATGGCGGAGGCGGGAGCAGGGCAGTGACGG GAGCCCCGAGTTCCTAGCGCTGCGGGGCGGGAGGCTACGAAGCGCTGCGCGGCCCCCTCGGGGCTGCCGGGCGCCGGGCTCGCCAGGCCT GGACAATAGCGCCGGGGAGCCGGAGGCGAGGAAAGGCGGCGGCCCAGAGCTCGGTCCCTGGAGCGGGCCATGCAGGCGGCGGCGCGGCCC CGCGGCGCCCAGCGGCGGCAGTGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTC CTGGGCGTCTACTGGCGGGGCCCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACG AGGACCGGCAGTGGGACGACCGGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTG AGAGCGACGGTTCTCTACTTTTAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAG CAGAAAATTATGACTTGGCCCTTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACC CTTCCGTGGACATCACTCAGGACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTT GTGAATTAAGTCGCCTTGAAGAAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAG AAAATGAGGGTTATATTAAAAAGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAA TTATCAAAGGCATCTTTCTCTTGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAG AATATGATCCTGCTTTATCACAACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATC CTGAGCTGAAACAAAAAATTCATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACA TGTTATCAACACTTCACTCTTTTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCA TTTCATTGGATAACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCG GGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTT CGTTGCTGTCGGTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCA TCCCATTACAGATAGAAGAGTATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCT GGGACTCTGTGTCCATTATCTCGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTG GCTCCCTGGAAGAGATCAAGCCATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGG CCTGTCCCTGCAGACATGAGAGACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCA GAATGATTTTACGGAGATATCCCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGA CACATCTCTGATACTTTTTTCATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCC CTTGGGCAGGTCACACAACCTGTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAAT >In-frame_ENST00000554684_ENST00000290219_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=546AA_start in transcript=224_stop in transcript=1864 MRGPLGAAGRRARQAWTIAPGSRRRGKAAAQSSVPGAGHAGGGAAPRRPAAAVRPGSPPLAGALTPRPSPLQGPFPGRLLAGPPPRFPGG TMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAG CDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHV CEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQY IQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADA STELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQE -------------------------------------------------------------- >In-frame_ENST00000554684_ENST00000381995_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2424nt_BP=1412nt CGCCTGTCGGCTTCTGACGTTTAAAACAGGGGGAGCGGAAGGGAGCCACTGGCCGCGGTGGCAGGGCCAGGTATAAGGAAGGAAAATATG GCGGCGGCGGCGGCGGCCTGAGGAGGCGGCGGCGGCGCGGGAAGCTGCTTCGCGGAGATCATGGCGGAGGCGGGAGCAGGGCAGTGACGG GAGCCCCGAGTTCCTAGCGCTGCGGGGCGGGAGGCTACGAAGCGCTGCGCGGCCCCCTCGGGGCTGCCGGGCGCCGGGCTCGCCAGGCCT GGACAATAGCGCCGGGGAGCCGGAGGCGAGGAAAGGCGGCGGCCCAGAGCTCGGTCCCTGGAGCGGGCCATGCAGGCGGCGGCGCGGCCC CGCGGCGCCCAGCGGCGGCAGTGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTC CTGGGCGTCTACTGGCGGGGCCCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACG AGGACCGGCAGTGGGACGACCGGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTG AGAGCGACGGTTCTCTACTTTTAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAG CAGAAAATTATGACTTGGCCCTTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACC CTTCCGTGGACATCACTCAGGACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTT GTGAATTAAGTCGCCTTGAAGAAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAG AAAATGAGGGTTATATTAAAAAGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAA TTATCAAAGGCATCTTTCTCTTGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAG AATATGATCCTGCTTTATCACAACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATC CTGAGCTGAAACAAAAAATTCATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACA TGTTATCAACACTTCACTCTTTTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCA TTTCATTGGATAACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCG GGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTT CGTTGCTGTCGGTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCA TCCCATTACAGATAGAAGAGTATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCT GGGACTCTGTGTCCATTATCTCGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTG GCTCCCTGGAAGAGATCAAGCCATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGG CCTGTCCCTGCAGACATGAGAGACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCA GAATGATTTTACGGAGATATCCCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGA CACATCTCTGATACTTTTTTCATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCC CTTGGGCAGGTCACACAACCTGTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAAT >In-frame_ENST00000554684_ENST00000381995_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=546AA_start in transcript=224_stop in transcript=1864 MRGPLGAAGRRARQAWTIAPGSRRRGKAAAQSSVPGAGHAGGGAAPRRPAAAVRPGSPPLAGALTPRPSPLQGPFPGRLLAGPPPRFPGG TMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAG CDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHV CEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQY IQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADA STELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQE -------------------------------------------------------------- >In-frame_ENST00000554684_ENST00000405436_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2405nt_BP=1412nt CGCCTGTCGGCTTCTGACGTTTAAAACAGGGGGAGCGGAAGGGAGCCACTGGCCGCGGTGGCAGGGCCAGGTATAAGGAAGGAAAATATG GCGGCGGCGGCGGCGGCCTGAGGAGGCGGCGGCGGCGCGGGAAGCTGCTTCGCGGAGATCATGGCGGAGGCGGGAGCAGGGCAGTGACGG GAGCCCCGAGTTCCTAGCGCTGCGGGGCGGGAGGCTACGAAGCGCTGCGCGGCCCCCTCGGGGCTGCCGGGCGCCGGGCTCGCCAGGCCT GGACAATAGCGCCGGGGAGCCGGAGGCGAGGAAAGGCGGCGGCCCAGAGCTCGGTCCCTGGAGCGGGCCATGCAGGCGGCGGCGCGGCCC CGCGGCGCCCAGCGGCGGCAGTGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTC CTGGGCGTCTACTGGCGGGGCCCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACG AGGACCGGCAGTGGGACGACCGGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTG AGAGCGACGGTTCTCTACTTTTAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAG CAGAAAATTATGACTTGGCCCTTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACC CTTCCGTGGACATCACTCAGGACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTT GTGAATTAAGTCGCCTTGAAGAAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAG AAAATGAGGGTTATATTAAAAAGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAA TTATCAAAGGCATCTTTCTCTTGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAG AATATGATCCTGCTTTATCACAACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATC CTGAGCTGAAACAAAAAATTCATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACA TGTTATCAACACTTCACTCTTTTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCA TTTCATTGGATAACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCG GGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTT CGTTGCTGTCGGTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCA TCCCATTACAGATAGAAGAGTATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCT GGGACTCTGTGTCCATTATCTCGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTG GCTCCCTGGAAGAGATCAAGCCATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGG CCTGTCCCTGCAGACATGAGAGACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCA GAATGATTTTACGGAGATATCCCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGA CACATCTCTGATACTTTTTTCATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCC CTTGGGCAGGTCACACAACCTGTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAAT >In-frame_ENST00000554684_ENST00000405436_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=546AA_start in transcript=224_stop in transcript=1864 MRGPLGAAGRRARQAWTIAPGSRRRGKAAAQSSVPGAGHAGGGAAPRRPAAAVRPGSPPLAGALTPRPSPLQGPFPGRLLAGPPPRFPGG TMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAG CDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHV CEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQY IQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADA STELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSVSIISFPEKEQE -------------------------------------------------------------- >In-frame_ENST00000554943_ENST00000290219_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2043nt_BP=1031nt TGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTCCTGGGCGTCTACTGGCGGGGC CCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACGAGGACCGGCAGTGGGACGACC GGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTGAGAGCGACGGTTCTCTACTTT TAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAGCAGAAAATTATGACTTGGCCC TTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACCCTTCCGTGGACATCACTCAGG ACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTTGTGAATTAAGTCGCCTTGAAG AAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAGAAAATGAGGGTTATATTAAAA AGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAATTATCAAAGGCATCTTTCTCT TGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAGAATATGATCCTGCTTTATCAC AACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATCCTGAGCTGAAACAAAAAATTC ATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACATGTTATCAACACTTCACTCTT TTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACTTAAAAC CCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTT GCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGCTGGCAG GAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAGT ATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCTGGGACTCTGTGTCCATTATCT CGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTGGCTCCCTGGAAGAGATCAAGC CATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGGCCTGTCCCTGCAGACATGAGA GACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCAGAATGATTTTACGGAGATATC CCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGACACATCTCTGATACTTTTTTC ATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCCCTTGGGCAGGTCACACAACCT GTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAATCTTGTAAATATACTCCTAGTA >In-frame_ENST00000554943_ENST00000290219_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=467AA_start in transcript=80_stop in transcript=1483 MAGPPPRFPGGTMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENY DLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEG YIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELK QKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLS NISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSV -------------------------------------------------------------- >In-frame_ENST00000554943_ENST00000381995_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2043nt_BP=1031nt TGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTCCTGGGCGTCTACTGGCGGGGC CCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACGAGGACCGGCAGTGGGACGACC GGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTGAGAGCGACGGTTCTCTACTTT TAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAGCAGAAAATTATGACTTGGCCC TTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACCCTTCCGTGGACATCACTCAGG ACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTTGTGAATTAAGTCGCCTTGAAG AAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAGAAAATGAGGGTTATATTAAAA AGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAATTATCAAAGGCATCTTTCTCT TGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAGAATATGATCCTGCTTTATCAC AACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATCCTGAGCTGAAACAAAAAATTC ATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACATGTTATCAACACTTCACTCTT TTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACTTAAAAC CCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTT GCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGCTGGCAG GAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAGT ATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCTGGGACTCTGTGTCCATTATCT CGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTGGCTCCCTGGAAGAGATCAAGC CATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGGCCTGTCCCTGCAGACATGAGA GACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCAGAATGATTTTACGGAGATATC CCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGACACATCTCTGATACTTTTTTC ATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCCCTTGGGCAGGTCACACAACCT GTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAATCTTGTAAATATACTCCTAGTA >In-frame_ENST00000554943_ENST00000381995_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=467AA_start in transcript=80_stop in transcript=1483 MAGPPPRFPGGTMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENY DLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEG YIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELK QKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLS NISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSV -------------------------------------------------------------- >In-frame_ENST00000554943_ENST00000405436_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(transcript)=2024nt_BP=1031nt TGAGGCCGGGGAGCCCTCCGCTCGCGGGCGCCCTCACGCCTCGCCCCTCGCCTCTCCAGGGCCCCTTTCCTGGGCGTCTACTGGCGGGGC CCCCGCCCCGGTTCCCGGGCGGCACGATGACCGACACCCGGCGGCGGGTGAAGGTGTACACGCTCAACGAGGACCGGCAGTGGGACGACC GGGGCACCGGGCATGTGTCGTCTGGCTACGTGGAGCGGCTGAAGGGCATGTCCCTGCTTGTCAGGGCTGAGAGCGACGGTTCTCTACTTT TAGAGTCGAAAATAAATCCTAACACTGCATACCAGAAACAACAGGACACTCTGATTGTGTGGTCTGAAGCAGAAAATTATGACTTGGCCC TTAGCTTTCAAGAAAAAGCTGGATGTGATGAAATTTGGGAGAAAATATGTCAGGTTCAAGGAAAGGACCCTTCCGTGGACATCACTCAGG ACCTTGTGGATGAATCTGAAGAGGAGCGTTTTGATGATATGTCATCGCCAGGCTTAGAATTGCCATCTTGTGAATTAAGTCGCCTTGAAG AAATTGCAGAACTTGTGGCATCATCTTTACCTTCACCTCTTCGTCGTGAAAAACTTGCACTGGCACTAGAAAATGAGGGTTATATTAAAA AGCTCCTGGAGCTTTTTCATGTGTGTGAAGATTTGGAAAATATTGAAGGACTGCACCACTTGTATGAAATTATCAAAGGCATCTTTCTCT TGAATCGAACTGCTCTTTTTGAAGTTATGTTCTCTGAAGAATGTATAATGGACGTCATTGGATGTTTAGAATATGATCCTGCTTTATCAC AACCACGAAAACACAGGGAATTTCTAACAAAAACAGCCAAGTTTAAAGAAGTGATTCCCATATCAGATCCTGAGCTGAAACAAAAAATTC ATCAGACATACAGAGTTCAGTATATACAAGATATGGTTCTACCAACTCCTTCGGTCTTTGAAGAAAACATGTTATCAACACTTCACTCTT TTATCTTTTTCAATAAGGTAGAGATTGTTGGCATGTTGCAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACTTAAAAC CCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTT GCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGCTGGCAG GAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAGT ATTTAAAAGACCCAACTCAGCCCATCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCTGGGACTCTGTGTCCATTATCT CGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCATGGGCCTAGCCCACTGGCTCCCTGGAAGAGATCAAGC CATCGGAGCTGCTAGAGTTCTGTCTGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGGCCTGTCCCTGCAGACATGAGA GACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTTCTTAAAGAATTTTCAAAATCAAATTCCAGAATGATTTTACGGAGATATC CCAGGAAAATTAAGGCTTCTCTTAAACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGACACATCTCTGATACTTTTTTC ATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAAATGAGCCGGAGCCCCTTGGGCAGGTCACACAACCT GTCCCAGCGAGGGACACCGAGTGGCCCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAATCTTGTAAATATACTCCTAGTA >In-frame_ENST00000554943_ENST00000405436_43N_SMEK1_chr14_91947919_-_IFNGR2_chr21_34804483_length(amino acids)=467AA_start in transcript=80_stop in transcript=1483 MAGPPPRFPGGTMTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENY DLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEG YIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELK QKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQVKGPFRSNSISLDNLKPSRVYCLQVQAQLLWNKSNIFRVGHLS NISCYETMADASTELQQVILISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQPILEALDKDSSPKDDVWDSV -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SMEK1-IFNGR2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SMEK1-IFNGR2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IFNGR2 | P38484 | DB00033 | Interferon gamma-1b | Binder | Biotech | Approved|Investigational |
Tgene | IFNGR2 | P38484 | DB00033 | Interferon gamma-1b | Binder | Biotech | Approved|Investigational |
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Related Diseases for SMEK1-IFNGR2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IFNGR2 | C4013947 | IMMUNODEFICIENCY 28 | 5 | CTD_human;GENOMICS_ENGLAND;UNIPROT |