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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMG1-SNF8 (FusionGDB2 ID:83497)

Fusion Gene Summary for SMG1-SNF8

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG1-SNF8
Fusion gene ID: 83497
HgeneTgene
Gene symbol

SMG1

SNF8

Gene ID

23049

11267

Gene nameSMG1 nonsense mediated mRNA decay associated PI3K related kinaseSNF8 subunit of ESCRT-II
Synonyms61E3.4|ATX|LIPDot3|EAP30|VPS22
Cytomap

16p12.3

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinasevacuolar-sorting protein SNF8EAP30 subunit of ELL complexELL-associated protein of 30 kDaESCRT-II complex subunit VPS22SNF8, ESCRT-II complex subunit, homolog
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000389467, ENST00000446231, 
ENST00000565224, ENST00000567737, 
ENST00000502492, ENST00000290330, 
ENST00000514089, 
Fusion gene scores* DoF score28 X 23 X 9=57966 X 5 X 5=150
# samples 3110
** MAII scorelog2(31/5796*10)=-4.22471747428269
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/150*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMG1 [Title/Abstract] AND SNF8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG1(18937272)-SNF8(47018424), # samples:2
SMG1(18937271)-SNF8(47018424), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG1

GO:0000184

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

11544179

HgeneSMG1

GO:0018105

peptidyl-serine phosphorylation

11544179|15175154

HgeneSMG1

GO:0046777

protein autophosphorylation

11331269|11544179

HgeneSMG1

GO:0046854

phosphatidylinositol phosphorylation

11331269

HgeneSMG1

GO:2001020

regulation of response to DNA damage stimulus

15175154

TgeneSNF8

GO:0006357

regulation of transcription by RNA polymerase II

10419521


check buttonFusion gene breakpoints across SMG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SNF8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XJ-A9DK-01ASMG1chr16

18937272

-SNF8chr17

47018424

-
ChimerDB4PRADTCGA-XJ-A9DKSMG1chr16

18937271

-SNF8chr17

47018424

-
ChimerDB4PRADTCGA-XJ-A9DKSMG1chr16

18937271

-SNF8chr17

47018424

-
ChimerDB4PRADTCGA-XJ-A9DK-01ASMG1chr16

18937272

-SNF8chr17

47018424

-


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Fusion Gene ORF analysis for SMG1-SNF8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000389467ENST00000502492SMG1chr16

18937272

-SNF8chr17

47018424

-
In-frameENST00000389467ENST00000290330SMG1chr16

18937272

-SNF8chr17

47018424

-
5CDS-intronENST00000389467ENST00000514089SMG1chr16

18937272

-SNF8chr17

47018424

-
In-frameENST00000446231ENST00000502492SMG1chr16

18937272

-SNF8chr17

47018424

-
In-frameENST00000446231ENST00000290330SMG1chr16

18937272

-SNF8chr17

47018424

-
5CDS-intronENST00000446231ENST00000514089SMG1chr16

18937272

-SNF8chr17

47018424

-
intron-3CDSENST00000565224ENST00000502492SMG1chr16

18937272

-SNF8chr17

47018424

-
intron-3CDSENST00000565224ENST00000290330SMG1chr16

18937272

-SNF8chr17

47018424

-
intron-intronENST00000565224ENST00000514089SMG1chr16

18937272

-SNF8chr17

47018424

-
5UTR-3CDSENST00000567737ENST00000502492SMG1chr16

18937272

-SNF8chr17

47018424

-
5UTR-3CDSENST00000567737ENST00000290330SMG1chr16

18937272

-SNF8chr17

47018424

-
5UTR-intronENST00000567737ENST00000514089SMG1chr16

18937272

-SNF8chr17

47018424

-
In-frameENST00000389467ENST00000502492SMG1chr16

18937271

-SNF8chr17

47018424

-
In-frameENST00000389467ENST00000290330SMG1chr16

18937271

-SNF8chr17

47018424

-
5CDS-intronENST00000389467ENST00000514089SMG1chr16

18937271

-SNF8chr17

47018424

-
In-frameENST00000446231ENST00000502492SMG1chr16

18937271

-SNF8chr17

47018424

-
In-frameENST00000446231ENST00000290330SMG1chr16

18937271

-SNF8chr17

47018424

-
5CDS-intronENST00000446231ENST00000514089SMG1chr16

18937271

-SNF8chr17

47018424

-
intron-3CDSENST00000565224ENST00000502492SMG1chr16

18937271

-SNF8chr17

47018424

-
intron-3CDSENST00000565224ENST00000290330SMG1chr16

18937271

-SNF8chr17

47018424

-
intron-intronENST00000565224ENST00000514089SMG1chr16

18937271

-SNF8chr17

47018424

-
5UTR-3CDSENST00000567737ENST00000502492SMG1chr16

18937271

-SNF8chr17

47018424

-
5UTR-3CDSENST00000567737ENST00000290330SMG1chr16

18937271

-SNF8chr17

47018424

-
5UTR-intronENST00000567737ENST00000514089SMG1chr16

18937271

-SNF8chr17

47018424

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000389467SMG1chr1618937272-ENST00000502492SNF8chr1747018424-22864554431126227
ENST00000389467SMG1chr1618937272-ENST00000290330SNF8chr1747018424-12254554431123226
ENST00000446231SMG1chr1618937272-ENST00000502492SNF8chr1747018424-23365054931176227
ENST00000446231SMG1chr1618937272-ENST00000290330SNF8chr1747018424-12755054931173226
ENST00000389467SMG1chr1618937271-ENST00000502492SNF8chr1747018424-22864554431126227
ENST00000389467SMG1chr1618937271-ENST00000290330SNF8chr1747018424-12254554431123226
ENST00000446231SMG1chr1618937271-ENST00000502492SNF8chr1747018424-23365054931176227
ENST00000446231SMG1chr1618937271-ENST00000290330SNF8chr1747018424-12755054931173226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000389467ENST00000502492SMG1chr1618937272-SNF8chr1747018424-0.0039187160.9960813
ENST00000389467ENST00000290330SMG1chr1618937272-SNF8chr1747018424-0.0042766530.99572337
ENST00000446231ENST00000502492SMG1chr1618937272-SNF8chr1747018424-0.003607670.9963923
ENST00000446231ENST00000290330SMG1chr1618937272-SNF8chr1747018424-0.003821810.99617815
ENST00000389467ENST00000502492SMG1chr1618937271-SNF8chr1747018424-0.0039187160.9960813
ENST00000389467ENST00000290330SMG1chr1618937271-SNF8chr1747018424-0.0042766530.99572337
ENST00000446231ENST00000502492SMG1chr1618937271-SNF8chr1747018424-0.003607670.9963923
ENST00000446231ENST00000290330SMG1chr1618937271-SNF8chr1747018424-0.003821810.99617815

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Fusion Genomic Features for SMG1-SNF8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMG1-SNF8


check button Go to

FGviewer for the breakpoints of chr16:18937272-chr17:47018424

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG1chr16:18937271chr17:47018424ENST00000446231-1631283_186630.6666666666666683662.0DomainFAT
HgeneSMG1chr16:18937271chr17:47018424ENST00000446231-1632150_247830.6666666666666683662.0DomainPI3K/PI4K
HgeneSMG1chr16:18937271chr17:47018424ENST00000446231-1633629_366130.6666666666666683662.0DomainFATC
HgeneSMG1chr16:18937272chr17:47018424ENST00000446231-1631283_186630.6666666666666683662.0DomainFAT
HgeneSMG1chr16:18937272chr17:47018424ENST00000446231-1632150_247830.6666666666666683662.0DomainPI3K/PI4K
HgeneSMG1chr16:18937272chr17:47018424ENST00000446231-1633629_366130.6666666666666683662.0DomainFATC
HgeneSMG1chr16:18937271chr17:47018424ENST00000446231-1631817_185230.6666666666666683662.0RepeatNote=HEAT
HgeneSMG1chr16:18937272chr17:47018424ENST00000446231-1631817_185230.6666666666666683662.0RepeatNote=HEAT
TgeneSNF8chr16:18937271chr17:47018424ENST000002903301827_5335.0258.0Coiled coilOntology_term=ECO:0000255
TgeneSNF8chr16:18937271chr17:47018424ENST000005024921827_5335.0259.0Coiled coilOntology_term=ECO:0000255
TgeneSNF8chr16:18937272chr17:47018424ENST000002903301827_5335.0258.0Coiled coilOntology_term=ECO:0000255
TgeneSNF8chr16:18937272chr17:47018424ENST000005024921827_5335.0259.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for SMG1-SNF8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000389467_ENST00000502492_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(transcript)=2286nt_BP=455nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT
TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG
GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC
TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC
TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC
TGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGG
AACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCT
ACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGG
AGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTT
GAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACCTCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACA
TATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAAGAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAG
CTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTTTTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTA
AATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAGAGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGT
CAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAATGGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAA
ATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCAGGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTA
CCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCAAGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAG
GGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGCCTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGG
CAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGTCAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCA
AGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAAGGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGT
TTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATACTGAGACCCTTCCTTTAGCAGGATATAGCCTGGGCCCATCTCTTCCTCTGC

>In-frame_ENST00000389467_ENST00000502492_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(amino acids)=227AA_start in transcript=443_stop in transcript=1126
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQ

--------------------------------------------------------------
>In-frame_ENST00000389467_ENST00000290330_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(transcript)=1225nt_BP=455nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT
TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG
GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC
TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC
TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC
TGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAAC
ACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACT
CCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGG

>In-frame_ENST00000389467_ENST00000290330_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(amino acids)=226AA_start in transcript=443_stop in transcript=1123
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQV

--------------------------------------------------------------
>In-frame_ENST00000446231_ENST00000502492_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(transcript)=2336nt_BP=505nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT
GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT
GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT
GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA
GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA
CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGA
GATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACA
GGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCT
CCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAA
ATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACC
TCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAA
GAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTT
TTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAG
AGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAAT
GGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCA
GGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCA
AGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGC
CTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGT
CAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAA
GGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATAC

>In-frame_ENST00000446231_ENST00000502492_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(amino acids)=227AA_start in transcript=493_stop in transcript=1176
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQ

--------------------------------------------------------------
>In-frame_ENST00000446231_ENST00000290330_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(transcript)=1275nt_BP=505nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT
GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT
GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT
GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA
GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA
CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGAT
CAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGC
CCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCC
CTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATA

>In-frame_ENST00000446231_ENST00000290330_TCGA-XJ-A9DK-01A_SMG1_chr16_18937272_-_SNF8_chr17_47018424_length(amino acids)=226AA_start in transcript=493_stop in transcript=1173
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQV

--------------------------------------------------------------
>In-frame_ENST00000389467_ENST00000502492_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(transcript)=2286nt_BP=455nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT
TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG
GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC
TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC
TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC
TGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGG
AACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCT
ACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGG
AGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTT
GAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACCTCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACA
TATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAAGAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAG
CTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTTTTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTA
AATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAGAGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGT
CAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAATGGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAA
ATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCAGGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTA
CCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCAAGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAG
GGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGCCTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGG
CAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGTCAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCA
AGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAAGGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGT
TTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATACTGAGACCCTTCCTTTAGCAGGATATAGCCTGGGCCCATCTCTTCCTCTGC

>In-frame_ENST00000389467_ENST00000502492_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(amino acids)=227AA_start in transcript=443_stop in transcript=1126
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQ

--------------------------------------------------------------
>In-frame_ENST00000389467_ENST00000290330_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(transcript)=1225nt_BP=455nt
GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT
GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG
GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC
GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG
GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA
CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT
TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG
GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC
TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC
TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC
TGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAAC
ACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACT
CCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGG

>In-frame_ENST00000389467_ENST00000290330_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(amino acids)=226AA_start in transcript=443_stop in transcript=1123
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQV

--------------------------------------------------------------
>In-frame_ENST00000446231_ENST00000502492_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(transcript)=2336nt_BP=505nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT
GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT
GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT
GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA
GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA
CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGA
GATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACA
GGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCT
CCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAA
ATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACC
TCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAA
GAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTT
TTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAG
AGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAAT
GGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCA
GGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCA
AGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGC
CTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGT
CAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAA
GGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATAC

>In-frame_ENST00000446231_ENST00000502492_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(amino acids)=227AA_start in transcript=493_stop in transcript=1176
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKASLKWETERARQ

--------------------------------------------------------------
>In-frame_ENST00000446231_ENST00000290330_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(transcript)=1275nt_BP=505nt
GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT
CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC
CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC
TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC
GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG
GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT
GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT
GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT
GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA
GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA
CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGAT
CAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGC
CCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCC
CTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATA

>In-frame_ENST00000446231_ENST00000290330_TCGA-XJ-A9DK_SMG1_chr16_18937271_-_SNF8_chr17_47018424_length(amino acids)=226AA_start in transcript=493_stop in transcript=1173
MATQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITL
EELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAENGYVTVSEIKASLKWETERARQV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMG1-SNF8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG1chr16:18937271chr17:47018424ENST00000446231-1631_197730.6666666666666683662.0SMG8 and SMG9
HgeneSMG1chr16:18937272chr17:47018424ENST00000446231-1631_197730.6666666666666683662.0SMG8 and SMG9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG1-SNF8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG1-SNF8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource