FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SMG6-SLC16A14 (FusionGDB2 ID:83546)

Fusion Gene Summary for SMG6-SLC16A14

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG6-SLC16A14
Fusion gene ID: 83546
HgeneTgene
Gene symbol

SMG6

SLC16A14

Gene ID

23293

151473

Gene nameSMG6 nonsense mediated mRNA decay factorsolute carrier family 16 member 14
SynonymsC17orf31|EST1A|SMG-6|hSMG5/7aMCT14
Cytomap

17p13.3

2q36.3

Type of geneprotein-codingprotein-coding
Descriptiontelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1Amonocarboxylate transporter 14MCT 14monocarboxylic acid transporter 14solute carrier family 16 (monocarboxylic acid transporters), member 14
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000544865, ENST00000263073, 
ENST00000354901, ENST00000536871, 
ENST00000573166, 		ENST00000295190, 
Fusion gene scores* DoF score19 X 14 X 6=15963 X 3 X 3=27
# samples 193
** MAII scorelog2(19/1596*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMG6 [Title/Abstract] AND SLC16A14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG6(2139786)-SLC16A14(230914620), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087


check buttonFusion gene breakpoints across SMG6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC16A14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F0-01ASMG6chr17

2139786

-SLC16A14chr2

230914620

-


Top

Fusion Gene ORF analysis for SMG6-SLC16A14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544865ENST00000295190SMG6chr17

2139786

-SLC16A14chr2

230914620

-
In-frameENST00000263073ENST00000295190SMG6chr17

2139786

-SLC16A14chr2

230914620

-
In-frameENST00000354901ENST00000295190SMG6chr17

2139786

-SLC16A14chr2

230914620

-
In-frameENST00000536871ENST00000295190SMG6chr17

2139786

-SLC16A14chr2

230914620

-
intron-3CDSENST00000573166ENST00000295190SMG6chr17

2139786

-SLC16A14chr2

230914620

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544865SMG6chr172139786-ENST00000295190SLC16A14chr2230914620-6959328751145601349
ENST00000263073SMG6chr172139786-ENST00000295190SLC16A14chr2230914620-659229205141931380
ENST00000354901SMG6chr172139786-ENST00000295190SLC16A14chr2230914620-41124402321713493
ENST00000536871SMG6chr172139786-ENST00000295190SLC16A14chr2230914620-40593872421660472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544865ENST00000295190SMG6chr172139786-SLC16A14chr2230914620-0.0006223020.9993777
ENST00000263073ENST00000295190SMG6chr172139786-SLC16A14chr2230914620-0.0003879040.99961215
ENST00000354901ENST00000295190SMG6chr172139786-SLC16A14chr2230914620-0.0003146940.9996853
ENST00000536871ENST00000295190SMG6chr172139786-SLC16A14chr2230914620-0.0003292880.99967074

Top

Fusion Genomic Features for SMG6-SLC16A14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SMG6-SLC16A14


check button Go to

FGviewer for the breakpoints of chr17:2139786-chr2:230914620

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr2:230914620ENST00000263073-1019163_193956.33333333333341420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000263073-1019567_625956.33333333333341420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000544865-1019163_193925.33333333333341389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000544865-1019567_625925.33333333333341389.0Coiled coilOntology_term=ECO:0000255
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015495_51086.33333333333333511.0Topological domainCytoplasmic
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015103_12386.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015127_14786.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015159_17986.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015191_20986.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015315_33586.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015353_37386.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015379_39986.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015408_42886.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015443_46386.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST0000029519015474_49486.33333333333333511.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr2:230914620ENST00000263073-10191197_1239956.33333333333341420.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000354901-3121197_123948.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000354901-312163_19348.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000354901-312567_62548.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000536871-2111197_123948.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000536871-211163_19348.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000536871-211567_62548.333333333333336512.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000544865-10191197_1239925.33333333333341389.0Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr2:230914620ENST00000263073-10191246_1397956.33333333333341420.0DomainNote=PINc
HgeneSMG6chr17:2139786chr2:230914620ENST00000354901-3121246_139748.333333333333336512.0DomainNote=PINc
HgeneSMG6chr17:2139786chr2:230914620ENST00000536871-2111246_139748.333333333333336512.0DomainNote=PINc
HgeneSMG6chr17:2139786chr2:230914620ENST00000544865-10191246_1397925.33333333333341389.0DomainNote=PINc
TgeneSLC16A14chr17:2139786chr2:230914620ENST00000295190151_2786.33333333333333511.0Topological domainCytoplasmic
TgeneSLC16A14chr17:2139786chr2:230914620ENST000002951901528_4886.33333333333333511.0TransmembraneHelical
TgeneSLC16A14chr17:2139786chr2:230914620ENST000002951901574_9486.33333333333333511.0TransmembraneHelical


Top

Fusion Gene Sequence for SMG6-SLC16A14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000544865_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(transcript)=6959nt_BP=3287nt
AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC
TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC
CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC
CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC
AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA
TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG
CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG
TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT
GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG
TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG
TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT
TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG
AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG
GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG
CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA
GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA
CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA
TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT
TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG
ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC
TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC
ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC
CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC
AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT
GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA
GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA
GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG
GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA
AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG
CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT
TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG
CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA
AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC
TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG
CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC
ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA
GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGCCCTTTCATCGGCTTGTTCATTAACACCTGTGGGTGCCGCCA
GACTGCGATCATTGGAGGGCTCGTCAACTCCCTGGGCTGGGTGTTGAGTGCCTATGCTGCAAACGTGCATTATCTCTTCATTACTTTTGG
AGTCGCAGCTGGCCTGGGCAGCGGGATGGCCTACCTGCCAGCGGTGGTCATGGTGGGCAGGTATTTCCAGAAGAGACGCGCCCTCGCCCA
GGGCCTCAGCACCACGGGGACCGGATTCGGTACGTTCCTAATGACTGTGCTGCTGAAGTACCTGTGCGCAGAGTACGGCTGGAGGAATGC
CATGTTGATCCAAGGTGCCGTTTCCCTAAACCTGTGTGTTTGTGGGGCGCTCATGAGGCCCCTCTCTCCTGGTAAAAACCCAAACGACCC
AGGAGAGAAAGATGTGCGTGGCCTGCCAGCGCACTCCACAGAATCTGTGAAGTCAACTGGACAGCAGGGAAGAACAGAAGAGAAGGATGG
TGGGCTCGGGAACGAGGAGACCCTCTGCGACCTGCAAGCCCAGGAGTGCCCCGATCAGGCCGGGCACAGGAAGAACATGTGTGCCCTCCG
GATTCTGAAGACTGTCAGCTGGCTCACCATGAGAGTCAGGAAGGGCTTCGAGGACTGGTATTCGGGCTACTTTGGGACAGCCTCTCTATT
TACAAATCGAATGTTTGTAGCCTTTATTTTCTGGGCTTTGTTTGCATACAGCAGCTTTGTCATCCCCTTCATTCACCTCCCAGAAATCGT
CAATTTGTATAACTTATCGGAGCAAAACGACGTTTTCCCTCTGACGTCAATTATAGCAATAGTTCACATCTTTGGAAAAGTGATCCTGGG
CGTCATAGCCGACTTGCCTTGCATTAGTGTTTGGAATGTCTTCCTGTTGGCCAACTTCACCCTTGTCCTCAGTATTTTTATTCTGCCGTT
GATGCACACGTACGCTGGCCTGGCGGTCATCTGTGCGCTGATAGGGTTTTCCAGTGGTTATTTCTCCCTAATGCCCGTAGTGACTGAAGA
CTTGGTTGGCATTGAACACCTGGCCAATGCCTACGGCATCATCATCTGTGCTAATGGCATCTCTGCATTGCTGGGACCACCTTTTGCAGG
GTGGATCTATGACATCACGCAAAAATATGATTTTTCCTTCTACATATGTGGTTTGCTTTACATGATAGGAATACTCTTTTTACTTATTCA
GCCGTGCATTCGAATTATAGAACAATCCAGAAGAAAATACATGGATGGTGCACATGTTTAGTATCATGTAATGTTCCGTGTAGGTTTCAT
TGTAATACTCATGCCTACCTCGCATGGTTGCTGTGAGGCACCTATGACAGGACGTGGGAAAGCATTTTGTACGGTAACTGGCACTGTCAT
TTGTAAATGCCATTGTCACAGCCTCATTTGTAAGCAGCACTGCCTCTCTGTTTGGGGAGATGTAATGCTGGAAGATCTTAAGGACTACAT
ACATTCTAGAGATGACAGTGTTGTTCAAAGACAGCCTAGTAAGTAATTGGTAGAAATGCCCTTATAAAAACCATTCTCTTGTCATCTACT
GGGACTAGGGTTTTAAATACAGCTTTTAAAAACAAAAACAGGGAATAAAAGCTTTTCAACTCAACCACTTCTTTGTAAGACAAAACTGAA
GTATCTGTGTGCTTCCAGAAAGCTTACAGATAAATGGGTTTCAAGCACAAGAATATGACTAGATTTCAGAAATTAATTATTACAGGGAGC
TATTGATCTACTAGCATCAAACAAAGGCAAGCTCTAATTCCACAGGTAATACAATTTAGTGCAATTAAAGAAACACGGCTTGTATTTTTA
TGAGGGAATTCTGCAGCTAGGGATTGTGACTCCTAAATCCTCCTCTAAAAGAAGGCACTTGCCATTAATCCTAATTCAGTGCTATCCAGT
TATAAATGGAATCTTGAGACAAAACCTTAACAAAGAAATAACAGTAATGATTTCCTTAGCAGAAGCCGTATTTGTACGCACAACATTAAA
TCAAGGGCTACAATTCAAGCACTTTTATTCGTATCATTGGCCTCTTAGATGATATAAGCATGAGGTGGGGCCTGTAATATTTTTTTCTGA
GTTTCTTCTGCCCAAAAATATAATATAGAACTAATTGCTAACTGACAAATAAAGTTAATAGTTAAATCATCTCCAAGGAATGTTGCTAAT
CCAAAGTATAACACTATCAATTTGTGAGGATAATAAATGGAATGCCATTAGTGTAGATGTCTGTGCCACATCTGACACTGGAGTAGTGAT
AACAAATAGCCCATCTCTAGACTCTCGTGTTGTTATATAGACCATTCATTTGCCTGAGCGTGGCACAGTTTTAAAAATAGTTCTCTTGAT
TGATTTCATACAGAAGATGACTGTGATCCATGACATCTAATAATGCCCTTTCTTTATCTGAGATGTCTATTTTTCTAAGCCAAACGTTTT
TCAGACTGCAGAATGTTCTTCCCAGATCATTTGAAATTTCTGGCTGCCTTACTTGTTTACAGATAGTTTAAGACTATTTAAATTTCTACT
CACAATTTGATCATCACACACACACAAATCCTTGAATATCATTGCCAGTGTCTTAGGTCAAATTTACCTAAAGTGAATACAGCCCATTCT
CAATTATCCTTCACAATTAGACGCAGGAATGCTACTAGGAATTGGAATCAAACAATGCCACCCCAAGCGTAATTTTAGCCAGCAGTTTCA
GTTATACTCAACCATGCCCTTCTGAGCTGTTAACAAGTGATTCAATGGACAAGTTCTCTTTTTGTTCCATCTCCATTATTTCCTGCTCTA
ATGTATAGTGGGAGTGGTTGTGTAATGAAAGGACCACCAAAATAATAAAAGGCAGCTAATGGAAAGGAGAGACAAAAGCATGGTTAATAT
ATATACTTAATATTACCTCCAATGACTCGGGAATTGCCTGTAAATTATTATAGACAATAGATTGCATGTCATACTCCATTTGGTTCAACA
CAACAACCTATGTGTTATCATTACAGCTTTGGCTGCTGTTAAAGAATCCAGCTCTCTATTTTGATAAAGATAATCTTAAAGCTGAGGCAA
TGCTCCCTCCTCTATCTCTCTCTGTGTAATTTACCATAGAATTAGGATGATTAGATTGAAACACATGTTGTATGTTTTAAAAACTACATT
GCTTCATTACTTTCATTTTCCGACAACATCAAACTAACAAGAGGCAGTGTTAAATATTTTAAATGGTGCTATAGCCAATGTATTTGAATG
CTTGCACTGCTGGTTGTGTATCATCAATATGAACTTTTTATCCAATGACTCAACTCTAATTACATCTAAGTTAGACTTGCTCACGTTCAG
TTTGTACAGTTGTGTGTTGACTTACTATGTTTTGAAAGTGGTGACTTCTACCGAATGAGTGGAAGTTCCCATTGTCAAAAAAAATAAAGA
CCTGCTTGCAGTATTCATGTTGACAACAGAGTAAAAGAGAATACTGTAAAGAATTACTGCAAATATTTCCTGTTTATGTTATTTGCCGTT
GTTTGAAGATATTATAAAGGGTTAATTGTATATTTATATCATGTGCTTTATCGTTTTCCCCTCATGTATCCAAGTAATTTTTATTTACAT

>In-frame_ENST00000544865_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(amino acids)=1349AA_start in transcript=511_stop in transcript=4560
MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF
PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA
AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST
DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK
QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD
EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ
HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD
PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA
RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS
TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP
SPIGSTRMLQLMTINMFAVHNSQLKGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGR
YFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLPAHSTESVKSTG
QQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWALFAYSSFV
IPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGY

--------------------------------------------------------------
>In-frame_ENST00000263073_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(transcript)=6592nt_BP=2920nt
GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG
GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT
AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA
TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC
CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA
ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG
GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT
AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG
GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC
TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG
GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT
GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT
AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG
GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT
CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG
CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG
AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG
GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG
GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG
TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG
CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG
CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG
TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA
CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC
ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA
GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC
AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA
GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG
CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG
GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG
AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT
GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG
ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGCCCTTTCATCGGCTTGTTCATTAACACCTGTGGGTGCCGCCAGACTGCG
ATCATTGGAGGGCTCGTCAACTCCCTGGGCTGGGTGTTGAGTGCCTATGCTGCAAACGTGCATTATCTCTTCATTACTTTTGGAGTCGCA
GCTGGCCTGGGCAGCGGGATGGCCTACCTGCCAGCGGTGGTCATGGTGGGCAGGTATTTCCAGAAGAGACGCGCCCTCGCCCAGGGCCTC
AGCACCACGGGGACCGGATTCGGTACGTTCCTAATGACTGTGCTGCTGAAGTACCTGTGCGCAGAGTACGGCTGGAGGAATGCCATGTTG
ATCCAAGGTGCCGTTTCCCTAAACCTGTGTGTTTGTGGGGCGCTCATGAGGCCCCTCTCTCCTGGTAAAAACCCAAACGACCCAGGAGAG
AAAGATGTGCGTGGCCTGCCAGCGCACTCCACAGAATCTGTGAAGTCAACTGGACAGCAGGGAAGAACAGAAGAGAAGGATGGTGGGCTC
GGGAACGAGGAGACCCTCTGCGACCTGCAAGCCCAGGAGTGCCCCGATCAGGCCGGGCACAGGAAGAACATGTGTGCCCTCCGGATTCTG
AAGACTGTCAGCTGGCTCACCATGAGAGTCAGGAAGGGCTTCGAGGACTGGTATTCGGGCTACTTTGGGACAGCCTCTCTATTTACAAAT
CGAATGTTTGTAGCCTTTATTTTCTGGGCTTTGTTTGCATACAGCAGCTTTGTCATCCCCTTCATTCACCTCCCAGAAATCGTCAATTTG
TATAACTTATCGGAGCAAAACGACGTTTTCCCTCTGACGTCAATTATAGCAATAGTTCACATCTTTGGAAAAGTGATCCTGGGCGTCATA
GCCGACTTGCCTTGCATTAGTGTTTGGAATGTCTTCCTGTTGGCCAACTTCACCCTTGTCCTCAGTATTTTTATTCTGCCGTTGATGCAC
ACGTACGCTGGCCTGGCGGTCATCTGTGCGCTGATAGGGTTTTCCAGTGGTTATTTCTCCCTAATGCCCGTAGTGACTGAAGACTTGGTT
GGCATTGAACACCTGGCCAATGCCTACGGCATCATCATCTGTGCTAATGGCATCTCTGCATTGCTGGGACCACCTTTTGCAGGGTGGATC
TATGACATCACGCAAAAATATGATTTTTCCTTCTACATATGTGGTTTGCTTTACATGATAGGAATACTCTTTTTACTTATTCAGCCGTGC
ATTCGAATTATAGAACAATCCAGAAGAAAATACATGGATGGTGCACATGTTTAGTATCATGTAATGTTCCGTGTAGGTTTCATTGTAATA
CTCATGCCTACCTCGCATGGTTGCTGTGAGGCACCTATGACAGGACGTGGGAAAGCATTTTGTACGGTAACTGGCACTGTCATTTGTAAA
TGCCATTGTCACAGCCTCATTTGTAAGCAGCACTGCCTCTCTGTTTGGGGAGATGTAATGCTGGAAGATCTTAAGGACTACATACATTCT
AGAGATGACAGTGTTGTTCAAAGACAGCCTAGTAAGTAATTGGTAGAAATGCCCTTATAAAAACCATTCTCTTGTCATCTACTGGGACTA
GGGTTTTAAATACAGCTTTTAAAAACAAAAACAGGGAATAAAAGCTTTTCAACTCAACCACTTCTTTGTAAGACAAAACTGAAGTATCTG
TGTGCTTCCAGAAAGCTTACAGATAAATGGGTTTCAAGCACAAGAATATGACTAGATTTCAGAAATTAATTATTACAGGGAGCTATTGAT
CTACTAGCATCAAACAAAGGCAAGCTCTAATTCCACAGGTAATACAATTTAGTGCAATTAAAGAAACACGGCTTGTATTTTTATGAGGGA
ATTCTGCAGCTAGGGATTGTGACTCCTAAATCCTCCTCTAAAAGAAGGCACTTGCCATTAATCCTAATTCAGTGCTATCCAGTTATAAAT
GGAATCTTGAGACAAAACCTTAACAAAGAAATAACAGTAATGATTTCCTTAGCAGAAGCCGTATTTGTACGCACAACATTAAATCAAGGG
CTACAATTCAAGCACTTTTATTCGTATCATTGGCCTCTTAGATGATATAAGCATGAGGTGGGGCCTGTAATATTTTTTTCTGAGTTTCTT
CTGCCCAAAAATATAATATAGAACTAATTGCTAACTGACAAATAAAGTTAATAGTTAAATCATCTCCAAGGAATGTTGCTAATCCAAAGT
ATAACACTATCAATTTGTGAGGATAATAAATGGAATGCCATTAGTGTAGATGTCTGTGCCACATCTGACACTGGAGTAGTGATAACAAAT
AGCCCATCTCTAGACTCTCGTGTTGTTATATAGACCATTCATTTGCCTGAGCGTGGCACAGTTTTAAAAATAGTTCTCTTGATTGATTTC
ATACAGAAGATGACTGTGATCCATGACATCTAATAATGCCCTTTCTTTATCTGAGATGTCTATTTTTCTAAGCCAAACGTTTTTCAGACT
GCAGAATGTTCTTCCCAGATCATTTGAAATTTCTGGCTGCCTTACTTGTTTACAGATAGTTTAAGACTATTTAAATTTCTACTCACAATT
TGATCATCACACACACACAAATCCTTGAATATCATTGCCAGTGTCTTAGGTCAAATTTACCTAAAGTGAATACAGCCCATTCTCAATTAT
CCTTCACAATTAGACGCAGGAATGCTACTAGGAATTGGAATCAAACAATGCCACCCCAAGCGTAATTTTAGCCAGCAGTTTCAGTTATAC
TCAACCATGCCCTTCTGAGCTGTTAACAAGTGATTCAATGGACAAGTTCTCTTTTTGTTCCATCTCCATTATTTCCTGCTCTAATGTATA
GTGGGAGTGGTTGTGTAATGAAAGGACCACCAAAATAATAAAAGGCAGCTAATGGAAAGGAGAGACAAAAGCATGGTTAATATATATACT
TAATATTACCTCCAATGACTCGGGAATTGCCTGTAAATTATTATAGACAATAGATTGCATGTCATACTCCATTTGGTTCAACACAACAAC
CTATGTGTTATCATTACAGCTTTGGCTGCTGTTAAAGAATCCAGCTCTCTATTTTGATAAAGATAATCTTAAAGCTGAGGCAATGCTCCC
TCCTCTATCTCTCTCTGTGTAATTTACCATAGAATTAGGATGATTAGATTGAAACACATGTTGTATGTTTTAAAAACTACATTGCTTCAT
TACTTTCATTTTCCGACAACATCAAACTAACAAGAGGCAGTGTTAAATATTTTAAATGGTGCTATAGCCAATGTATTTGAATGCTTGCAC
TGCTGGTTGTGTATCATCAATATGAACTTTTTATCCAATGACTCAACTCTAATTACATCTAAGTTAGACTTGCTCACGTTCAGTTTGTAC
AGTTGTGTGTTGACTTACTATGTTTTGAAAGTGGTGACTTCTACCGAATGAGTGGAAGTTCCCATTGTCAAAAAAAATAAAGACCTGCTT
GCAGTATTCATGTTGACAACAGAGTAAAAGAGAATACTGTAAAGAATTACTGCAAATATTTCCTGTTTATGTTATTTGCCGTTGTTTGAA
GATATTATAAAGGGTTAATTGTATATTTATATCATGTGCTTTATCGTTTTCCCCTCATGTATCCAAGTAATTTTTATTTACATACAACTA

>In-frame_ENST00000263073_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(amino acids)=1380AA_start in transcript=51_stop in transcript=4193
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG
TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG
AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG
TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD
IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF
EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYA
ANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMR
PLSPGKNPNDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDW
YSGYFGTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANF
TLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLL

--------------------------------------------------------------
>In-frame_ENST00000354901_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(transcript)=4112nt_BP=440nt
GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG
TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC
ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA
TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG
CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGCCCTTTCAT
CGGCTTGTTCATTAACACCTGTGGGTGCCGCCAGACTGCGATCATTGGAGGGCTCGTCAACTCCCTGGGCTGGGTGTTGAGTGCCTATGC
TGCAAACGTGCATTATCTCTTCATTACTTTTGGAGTCGCAGCTGGCCTGGGCAGCGGGATGGCCTACCTGCCAGCGGTGGTCATGGTGGG
CAGGTATTTCCAGAAGAGACGCGCCCTCGCCCAGGGCCTCAGCACCACGGGGACCGGATTCGGTACGTTCCTAATGACTGTGCTGCTGAA
GTACCTGTGCGCAGAGTACGGCTGGAGGAATGCCATGTTGATCCAAGGTGCCGTTTCCCTAAACCTGTGTGTTTGTGGGGCGCTCATGAG
GCCCCTCTCTCCTGGTAAAAACCCAAACGACCCAGGAGAGAAAGATGTGCGTGGCCTGCCAGCGCACTCCACAGAATCTGTGAAGTCAAC
TGGACAGCAGGGAAGAACAGAAGAGAAGGATGGTGGGCTCGGGAACGAGGAGACCCTCTGCGACCTGCAAGCCCAGGAGTGCCCCGATCA
GGCCGGGCACAGGAAGAACATGTGTGCCCTCCGGATTCTGAAGACTGTCAGCTGGCTCACCATGAGAGTCAGGAAGGGCTTCGAGGACTG
GTATTCGGGCTACTTTGGGACAGCCTCTCTATTTACAAATCGAATGTTTGTAGCCTTTATTTTCTGGGCTTTGTTTGCATACAGCAGCTT
TGTCATCCCCTTCATTCACCTCCCAGAAATCGTCAATTTGTATAACTTATCGGAGCAAAACGACGTTTTCCCTCTGACGTCAATTATAGC
AATAGTTCACATCTTTGGAAAAGTGATCCTGGGCGTCATAGCCGACTTGCCTTGCATTAGTGTTTGGAATGTCTTCCTGTTGGCCAACTT
CACCCTTGTCCTCAGTATTTTTATTCTGCCGTTGATGCACACGTACGCTGGCCTGGCGGTCATCTGTGCGCTGATAGGGTTTTCCAGTGG
TTATTTCTCCCTAATGCCCGTAGTGACTGAAGACTTGGTTGGCATTGAACACCTGGCCAATGCCTACGGCATCATCATCTGTGCTAATGG
CATCTCTGCATTGCTGGGACCACCTTTTGCAGGGTGGATCTATGACATCACGCAAAAATATGATTTTTCCTTCTACATATGTGGTTTGCT
TTACATGATAGGAATACTCTTTTTACTTATTCAGCCGTGCATTCGAATTATAGAACAATCCAGAAGAAAATACATGGATGGTGCACATGT
TTAGTATCATGTAATGTTCCGTGTAGGTTTCATTGTAATACTCATGCCTACCTCGCATGGTTGCTGTGAGGCACCTATGACAGGACGTGG
GAAAGCATTTTGTACGGTAACTGGCACTGTCATTTGTAAATGCCATTGTCACAGCCTCATTTGTAAGCAGCACTGCCTCTCTGTTTGGGG
AGATGTAATGCTGGAAGATCTTAAGGACTACATACATTCTAGAGATGACAGTGTTGTTCAAAGACAGCCTAGTAAGTAATTGGTAGAAAT
GCCCTTATAAAAACCATTCTCTTGTCATCTACTGGGACTAGGGTTTTAAATACAGCTTTTAAAAACAAAAACAGGGAATAAAAGCTTTTC
AACTCAACCACTTCTTTGTAAGACAAAACTGAAGTATCTGTGTGCTTCCAGAAAGCTTACAGATAAATGGGTTTCAAGCACAAGAATATG
ACTAGATTTCAGAAATTAATTATTACAGGGAGCTATTGATCTACTAGCATCAAACAAAGGCAAGCTCTAATTCCACAGGTAATACAATTT
AGTGCAATTAAAGAAACACGGCTTGTATTTTTATGAGGGAATTCTGCAGCTAGGGATTGTGACTCCTAAATCCTCCTCTAAAAGAAGGCA
CTTGCCATTAATCCTAATTCAGTGCTATCCAGTTATAAATGGAATCTTGAGACAAAACCTTAACAAAGAAATAACAGTAATGATTTCCTT
AGCAGAAGCCGTATTTGTACGCACAACATTAAATCAAGGGCTACAATTCAAGCACTTTTATTCGTATCATTGGCCTCTTAGATGATATAA
GCATGAGGTGGGGCCTGTAATATTTTTTTCTGAGTTTCTTCTGCCCAAAAATATAATATAGAACTAATTGCTAACTGACAAATAAAGTTA
ATAGTTAAATCATCTCCAAGGAATGTTGCTAATCCAAAGTATAACACTATCAATTTGTGAGGATAATAAATGGAATGCCATTAGTGTAGA
TGTCTGTGCCACATCTGACACTGGAGTAGTGATAACAAATAGCCCATCTCTAGACTCTCGTGTTGTTATATAGACCATTCATTTGCCTGA
GCGTGGCACAGTTTTAAAAATAGTTCTCTTGATTGATTTCATACAGAAGATGACTGTGATCCATGACATCTAATAATGCCCTTTCTTTAT
CTGAGATGTCTATTTTTCTAAGCCAAACGTTTTTCAGACTGCAGAATGTTCTTCCCAGATCATTTGAAATTTCTGGCTGCCTTACTTGTT
TACAGATAGTTTAAGACTATTTAAATTTCTACTCACAATTTGATCATCACACACACACAAATCCTTGAATATCATTGCCAGTGTCTTAGG
TCAAATTTACCTAAAGTGAATACAGCCCATTCTCAATTATCCTTCACAATTAGACGCAGGAATGCTACTAGGAATTGGAATCAAACAATG
CCACCCCAAGCGTAATTTTAGCCAGCAGTTTCAGTTATACTCAACCATGCCCTTCTGAGCTGTTAACAAGTGATTCAATGGACAAGTTCT
CTTTTTGTTCCATCTCCATTATTTCCTGCTCTAATGTATAGTGGGAGTGGTTGTGTAATGAAAGGACCACCAAAATAATAAAAGGCAGCT
AATGGAAAGGAGAGACAAAAGCATGGTTAATATATATACTTAATATTACCTCCAATGACTCGGGAATTGCCTGTAAATTATTATAGACAA
TAGATTGCATGTCATACTCCATTTGGTTCAACACAACAACCTATGTGTTATCATTACAGCTTTGGCTGCTGTTAAAGAATCCAGCTCTCT
ATTTTGATAAAGATAATCTTAAAGCTGAGGCAATGCTCCCTCCTCTATCTCTCTCTGTGTAATTTACCATAGAATTAGGATGATTAGATT
GAAACACATGTTGTATGTTTTAAAAACTACATTGCTTCATTACTTTCATTTTCCGACAACATCAAACTAACAAGAGGCAGTGTTAAATAT
TTTAAATGGTGCTATAGCCAATGTATTTGAATGCTTGCACTGCTGGTTGTGTATCATCAATATGAACTTTTTATCCAATGACTCAACTCT
AATTACATCTAAGTTAGACTTGCTCACGTTCAGTTTGTACAGTTGTGTGTTGACTTACTATGTTTTGAAAGTGGTGACTTCTACCGAATG
AGTGGAAGTTCCCATTGTCAAAAAAAATAAAGACCTGCTTGCAGTATTCATGTTGACAACAGAGTAAAAGAGAATACTGTAAAGAATTAC
TGCAAATATTTCCTGTTTATGTTATTTGCCGTTGTTTGAAGATATTATAAAGGGTTAATTGTATATTTATATCATGTGCTTTATCGTTTT

>In-frame_ENST00000354901_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(amino acids)=493AA_start in transcript=232_stop in transcript=1713
MNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGPFIGLFINTCGCRQTAIIGG
LVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGA
VSLNLCVCGALMRPLSPGKNPNDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKNMCALRILKTVS
WLTMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLP
CISVWNVFLLANFTLVLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDIT

--------------------------------------------------------------
>In-frame_ENST00000536871_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(transcript)=4059nt_BP=387nt
ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA
GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA
TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA
AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT
TTGCAGTACACAACTCCCAGCTGAAAGGCCCTTTCATCGGCTTGTTCATTAACACCTGTGGGTGCCGCCAGACTGCGATCATTGGAGGGC
TCGTCAACTCCCTGGGCTGGGTGTTGAGTGCCTATGCTGCAAACGTGCATTATCTCTTCATTACTTTTGGAGTCGCAGCTGGCCTGGGCA
GCGGGATGGCCTACCTGCCAGCGGTGGTCATGGTGGGCAGGTATTTCCAGAAGAGACGCGCCCTCGCCCAGGGCCTCAGCACCACGGGGA
CCGGATTCGGTACGTTCCTAATGACTGTGCTGCTGAAGTACCTGTGCGCAGAGTACGGCTGGAGGAATGCCATGTTGATCCAAGGTGCCG
TTTCCCTAAACCTGTGTGTTTGTGGGGCGCTCATGAGGCCCCTCTCTCCTGGTAAAAACCCAAACGACCCAGGAGAGAAAGATGTGCGTG
GCCTGCCAGCGCACTCCACAGAATCTGTGAAGTCAACTGGACAGCAGGGAAGAACAGAAGAGAAGGATGGTGGGCTCGGGAACGAGGAGA
CCCTCTGCGACCTGCAAGCCCAGGAGTGCCCCGATCAGGCCGGGCACAGGAAGAACATGTGTGCCCTCCGGATTCTGAAGACTGTCAGCT
GGCTCACCATGAGAGTCAGGAAGGGCTTCGAGGACTGGTATTCGGGCTACTTTGGGACAGCCTCTCTATTTACAAATCGAATGTTTGTAG
CCTTTATTTTCTGGGCTTTGTTTGCATACAGCAGCTTTGTCATCCCCTTCATTCACCTCCCAGAAATCGTCAATTTGTATAACTTATCGG
AGCAAAACGACGTTTTCCCTCTGACGTCAATTATAGCAATAGTTCACATCTTTGGAAAAGTGATCCTGGGCGTCATAGCCGACTTGCCTT
GCATTAGTGTTTGGAATGTCTTCCTGTTGGCCAACTTCACCCTTGTCCTCAGTATTTTTATTCTGCCGTTGATGCACACGTACGCTGGCC
TGGCGGTCATCTGTGCGCTGATAGGGTTTTCCAGTGGTTATTTCTCCCTAATGCCCGTAGTGACTGAAGACTTGGTTGGCATTGAACACC
TGGCCAATGCCTACGGCATCATCATCTGTGCTAATGGCATCTCTGCATTGCTGGGACCACCTTTTGCAGGGTGGATCTATGACATCACGC
AAAAATATGATTTTTCCTTCTACATATGTGGTTTGCTTTACATGATAGGAATACTCTTTTTACTTATTCAGCCGTGCATTCGAATTATAG
AACAATCCAGAAGAAAATACATGGATGGTGCACATGTTTAGTATCATGTAATGTTCCGTGTAGGTTTCATTGTAATACTCATGCCTACCT
CGCATGGTTGCTGTGAGGCACCTATGACAGGACGTGGGAAAGCATTTTGTACGGTAACTGGCACTGTCATTTGTAAATGCCATTGTCACA
GCCTCATTTGTAAGCAGCACTGCCTCTCTGTTTGGGGAGATGTAATGCTGGAAGATCTTAAGGACTACATACATTCTAGAGATGACAGTG
TTGTTCAAAGACAGCCTAGTAAGTAATTGGTAGAAATGCCCTTATAAAAACCATTCTCTTGTCATCTACTGGGACTAGGGTTTTAAATAC
AGCTTTTAAAAACAAAAACAGGGAATAAAAGCTTTTCAACTCAACCACTTCTTTGTAAGACAAAACTGAAGTATCTGTGTGCTTCCAGAA
AGCTTACAGATAAATGGGTTTCAAGCACAAGAATATGACTAGATTTCAGAAATTAATTATTACAGGGAGCTATTGATCTACTAGCATCAA
ACAAAGGCAAGCTCTAATTCCACAGGTAATACAATTTAGTGCAATTAAAGAAACACGGCTTGTATTTTTATGAGGGAATTCTGCAGCTAG
GGATTGTGACTCCTAAATCCTCCTCTAAAAGAAGGCACTTGCCATTAATCCTAATTCAGTGCTATCCAGTTATAAATGGAATCTTGAGAC
AAAACCTTAACAAAGAAATAACAGTAATGATTTCCTTAGCAGAAGCCGTATTTGTACGCACAACATTAAATCAAGGGCTACAATTCAAGC
ACTTTTATTCGTATCATTGGCCTCTTAGATGATATAAGCATGAGGTGGGGCCTGTAATATTTTTTTCTGAGTTTCTTCTGCCCAAAAATA
TAATATAGAACTAATTGCTAACTGACAAATAAAGTTAATAGTTAAATCATCTCCAAGGAATGTTGCTAATCCAAAGTATAACACTATCAA
TTTGTGAGGATAATAAATGGAATGCCATTAGTGTAGATGTCTGTGCCACATCTGACACTGGAGTAGTGATAACAAATAGCCCATCTCTAG
ACTCTCGTGTTGTTATATAGACCATTCATTTGCCTGAGCGTGGCACAGTTTTAAAAATAGTTCTCTTGATTGATTTCATACAGAAGATGA
CTGTGATCCATGACATCTAATAATGCCCTTTCTTTATCTGAGATGTCTATTTTTCTAAGCCAAACGTTTTTCAGACTGCAGAATGTTCTT
CCCAGATCATTTGAAATTTCTGGCTGCCTTACTTGTTTACAGATAGTTTAAGACTATTTAAATTTCTACTCACAATTTGATCATCACACA
CACACAAATCCTTGAATATCATTGCCAGTGTCTTAGGTCAAATTTACCTAAAGTGAATACAGCCCATTCTCAATTATCCTTCACAATTAG
ACGCAGGAATGCTACTAGGAATTGGAATCAAACAATGCCACCCCAAGCGTAATTTTAGCCAGCAGTTTCAGTTATACTCAACCATGCCCT
TCTGAGCTGTTAACAAGTGATTCAATGGACAAGTTCTCTTTTTGTTCCATCTCCATTATTTCCTGCTCTAATGTATAGTGGGAGTGGTTG
TGTAATGAAAGGACCACCAAAATAATAAAAGGCAGCTAATGGAAAGGAGAGACAAAAGCATGGTTAATATATATACTTAATATTACCTCC
AATGACTCGGGAATTGCCTGTAAATTATTATAGACAATAGATTGCATGTCATACTCCATTTGGTTCAACACAACAACCTATGTGTTATCA
TTACAGCTTTGGCTGCTGTTAAAGAATCCAGCTCTCTATTTTGATAAAGATAATCTTAAAGCTGAGGCAATGCTCCCTCCTCTATCTCTC
TCTGTGTAATTTACCATAGAATTAGGATGATTAGATTGAAACACATGTTGTATGTTTTAAAAACTACATTGCTTCATTACTTTCATTTTC
CGACAACATCAAACTAACAAGAGGCAGTGTTAAATATTTTAAATGGTGCTATAGCCAATGTATTTGAATGCTTGCACTGCTGGTTGTGTA
TCATCAATATGAACTTTTTATCCAATGACTCAACTCTAATTACATCTAAGTTAGACTTGCTCACGTTCAGTTTGTACAGTTGTGTGTTGA
CTTACTATGTTTTGAAAGTGGTGACTTCTACCGAATGAGTGGAAGTTCCCATTGTCAAAAAAAATAAAGACCTGCTTGCAGTATTCATGT
TGACAACAGAGTAAAAGAGAATACTGTAAAGAATTACTGCAAATATTTCCTGTTTATGTTATTTGCCGTTGTTTGAAGATATTATAAAGG
GTTAATTGTATATTTATATCATGTGCTTTATCGTTTTCCCCTCATGTATCCAAGTAATTTTTATTTACATACAACTAAATAAATGTTGTC

>In-frame_ENST00000536871_ENST00000295190_TCGA-BH-A1F0-01A_SMG6_chr17_2139786_-_SLC16A14_chr2_230914620_length(amino acids)=472AA_start in transcript=242_stop in transcript=1660
METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFI
TFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNP
NDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDWYSGYFGTA
SLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTLVLSIFI
LPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SMG6-SLC16A14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSMG6chr17:2139786chr2:230914620ENST00000263073-1019114_503956.33333333333341420.0telomeric DNA
HgeneSMG6chr17:2139786chr2:230914620ENST00000544865-1019114_503925.33333333333341389.0telomeric DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG6chr17:2139786chr2:230914620ENST00000354901-312114_50348.333333333333336512.0telomeric DNA
HgeneSMG6chr17:2139786chr2:230914620ENST00000536871-211114_50348.333333333333336512.0telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SMG6-SLC16A14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SMG6-SLC16A14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource