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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMG7-ZC3H3 (FusionGDB2 ID:83562)

Fusion Gene Summary for SMG7-ZC3H3

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG7-ZC3H3
Fusion gene ID: 83562
HgeneTgene
Gene symbol

SMG7

ZC3H3

Gene ID

9887

23144

Gene nameSMG7 nonsense mediated mRNA decay factorzinc finger CCCH-type containing 3
SynonymsC1orf16|EST1C|SGA56MSMICL|ZC3HDC3
Cytomap

1q25.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SMG7EST1 telomerase component homolog CEST1-like protein Cbreast cancer-associated antigen SGA-56Mever shorter telomeres 1Csmg-7 homolog, nonsense mediated mRNA decay factorzinc finger CCCH domain-containing protein 3smad-interacting CPSF-like factorzinc finger CCCH-type domain containing 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000456731, ENST00000367537, 
ENST00000508461, ENST00000347615, 
ENST00000507469, ENST00000515829, 
ENST00000507406, 		ENST00000262577, 
Fusion gene scores* DoF score9 X 5 X 5=2258 X 7 X 6=336
# samples 99
** MAII scorelog2(9/225*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMG7 [Title/Abstract] AND ZC3H3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMG7(183441784)-ZC3H3(144557755), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SMG7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZC3H3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-GJ-A6C0SMG7chr1

183441784

+ZC3H3chr8

144557755

-


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Fusion Gene ORF analysis for SMG7-ZC3H3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000456731ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
5UTR-3CDSENST00000367537ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
5UTR-3CDSENST00000508461ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
In-frameENST00000347615ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
In-frameENST00000507469ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
In-frameENST00000515829ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-
intron-3CDSENST00000507406ENST00000262577SMG7chr1

183441784

+ZC3H3chr8

144557755

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000347615SMG7chr1183441784+ENST00000262577ZC3H3chr8144557755-1681148681279403
ENST00000507469SMG7chr1183441784+ENST00000262577ZC3H3chr8144557755-1680147671278403
ENST00000515829SMG7chr1183441784+ENST00000262577ZC3H3chr8144557755-1656123431254403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000347615ENST00000262577SMG7chr1183441784+ZC3H3chr8144557755-0.141418260.8585817
ENST00000507469ENST00000262577SMG7chr1183441784+ZC3H3chr8144557755-0.137414710.86258525
ENST00000515829ENST00000262577SMG7chr1183441784+ZC3H3chr8144557755-0.152480040.84752

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Fusion Genomic Features for SMG7-ZC3H3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMG7-ZC3H3


check button Go to

FGviewer for the breakpoints of chr1:183441784-chr8:144557755

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312873_881571.6666666666666949.0Compositional biasNote=Poly-Ser
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312667_695571.6666666666666949.0Zinc fingerC3H1-type 1
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312699_722571.6666666666666949.0Zinc fingerC3H1-type 2
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312723_749571.6666666666666949.0Zinc fingerC3H1-type 3
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312750_777571.6666666666666949.0Zinc fingerC3H1-type 4
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312778_800571.6666666666666949.0Zinc fingerC3H1-type 5

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG7chr1:183441784chr8:144557755ENST00000347615+122648_8439.6666666666666661138.0Compositional biasNote=Gln/Pro-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000347615+122922_10159.6666666666666661138.0Compositional biasNote=Ser-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000507469+123648_8439.6666666666666661179.0Compositional biasNote=Gln/Pro-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000507469+123922_10159.6666666666666661179.0Compositional biasNote=Ser-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000508461+122648_84301146.0Compositional biasNote=Gln/Pro-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000508461+122922_101501146.0Compositional biasNote=Ser-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000515829+122648_8439.6666666666666661092.0Compositional biasNote=Gln/Pro-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000515829+122922_10159.6666666666666661092.0Compositional biasNote=Ser-rich
HgeneSMG7chr1:183441784chr8:144557755ENST00000347615+122152_1859.6666666666666661138.0RepeatTPR 1
HgeneSMG7chr1:183441784chr8:144557755ENST00000347615+122187_2199.6666666666666661138.0RepeatTPR 2
HgeneSMG7chr1:183441784chr8:144557755ENST00000507469+123152_1859.6666666666666661179.0RepeatTPR 1
HgeneSMG7chr1:183441784chr8:144557755ENST00000507469+123187_2199.6666666666666661179.0RepeatTPR 2
HgeneSMG7chr1:183441784chr8:144557755ENST00000508461+122152_18501146.0RepeatTPR 1
HgeneSMG7chr1:183441784chr8:144557755ENST00000508461+122187_21901146.0RepeatTPR 2
HgeneSMG7chr1:183441784chr8:144557755ENST00000515829+122152_1859.6666666666666661092.0RepeatTPR 1
HgeneSMG7chr1:183441784chr8:144557755ENST00000515829+122187_2199.6666666666666661092.0RepeatTPR 2
TgeneZC3H3chr1:183441784chr8:144557755ENST00000262577312382_391571.6666666666666949.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for SMG7-ZC3H3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000347615_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(transcript)=1681nt_BP=148nt
GAGCCGGAGGAGAGGAAGATGGCGGCGGCCGCCAGCACCCGCGGTGCCGCGGGGCCGCTCCGAGGAGCCTGAGAGACCCACGGAGGCTTC
GCGGGAAGACGCGGCGGCGGCGGCGGAGGATGAGCCTGCAGAGCGCGCAGTACCTCCGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTG
CCAGCGGGGGTGGGAAAGCCCAACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTG
CCAACAAGCTCTCCAAGACCTCCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCT
GTAGCCGTTCCCTGGCCAGCCGGGCAGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACT
GCATGTACTACAACCGCTTCGGCAGGTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGT
TTGTCCGGGGCACCTGCAAGAAAACGGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCC
TGAAGGGCATCTGCAGCAACAGCAACTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCT
ACTGCCCCCTGGGTGCAAAGTGCAAGAAGAAACACACGCTGCTGTGCCCCGACTTTGCCCGCAGGGGGGCGTGTCCCCGCGGCGCCCAGT
GCCAGCTGCTCCACCGTACCCAGAAACGCCACAGTCGGCGGGCAGCCACGTCCCCCGCCCCAGGGCCCAGCGACGCAACCGCCAGGAGCA
GGGTCTCGGCCAGCCACGGGCCCAGGAAGCCTTCAGCATCCCAGCGCCCCACCAGGCAGACGCCCAGCTCGGCTGCCCTCACTGCGGCTG
CCGTGGCTGCACCTCCCCACTGCCCAGGGGGGTCAGCCTCTCCCTCATCCTCGAAGGCTTCCTCCTCCTCCTCCTCCTCCTCATCCCCTC
CCGCTTCCTTGGACCACGAGGCACCATCTCTCCAGGAGGCTGCCTTAGCAGCAGCGTGCTCCAACAGGCTCTGCAAGCTGCCTTCCTTCA
TCTCCCTGCAGTCCTCGCCGAGCCCAGGAGCCCAGCCCAGGGTCCGGGCCCCTAGGGCCCCCCTCACCAAGGACTCAGGGAAGCCTCTGC
ACATCAAACCACGTCTGTGAGGACCCCAGGGACCGGCCTGCACCTACCTCAGACCCTCATCCTTGGAGAGGAAAGAGGCTCTGTCCACCA
CTCTACCCCACAGGAGGGCCGCCCGCCACCAAGCCTCACCTGGGGGCCACAGGGACACTGCTCTGCCTGCCTGGCCCTCAACCTTCCATG
ACCAGCGTGTGCGCAGGGCCTGGTCTTCCTCCCCCAAGCCAGGCCCCTGTCCCCACCCCACCACCTTCCAGGGTGCCAGGCAGGGCTGGC
CTCCAGGCCTGTCCCCGACTGCCATTGGCAACAGTGGCCCTGCAGCCCCCAGCCCTCCCCACCCAGGTTTTCGGCCCAGTGAAGAGGCCA

>In-frame_ENST00000347615_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(amino acids)=403AA_start in transcript=68_stop in transcript=1279
MRDPRRLRGKTRRRRRRMSLQSAQYLRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTG
RLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEK
MPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGP
SDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNR

--------------------------------------------------------------
>In-frame_ENST00000507469_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(transcript)=1680nt_BP=147nt
AGCCGGAGGAGAGGAAGATGGCGGCGGCCGCCAGCACCCGCGGTGCCGCGGGGCCGCTCCGAGGAGCCTGAGAGACCCACGGAGGCTTCG
CGGGAAGACGCGGCGGCGGCGGCGGAGGATGAGCCTGCAGAGCGCGCAGTACCTCCGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGC
CAGCGGGGGTGGGAAAGCCCAACCGGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGC
CAACAAGCTCTCCAAGACCTCCGGCCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCTG
TAGCCGTTCCCTGGCCAGCCGGGCAGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACTG
CATGTACTACAACCGCTTCGGCAGGTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGTT
TGTCCGGGGCACCTGCAAGAAAACGGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCCT
GAAGGGCATCTGCAGCAACAGCAACTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCTA
CTGCCCCCTGGGTGCAAAGTGCAAGAAGAAACACACGCTGCTGTGCCCCGACTTTGCCCGCAGGGGGGCGTGTCCCCGCGGCGCCCAGTG
CCAGCTGCTCCACCGTACCCAGAAACGCCACAGTCGGCGGGCAGCCACGTCCCCCGCCCCAGGGCCCAGCGACGCAACCGCCAGGAGCAG
GGTCTCGGCCAGCCACGGGCCCAGGAAGCCTTCAGCATCCCAGCGCCCCACCAGGCAGACGCCCAGCTCGGCTGCCCTCACTGCGGCTGC
CGTGGCTGCACCTCCCCACTGCCCAGGGGGGTCAGCCTCTCCCTCATCCTCGAAGGCTTCCTCCTCCTCCTCCTCCTCCTCATCCCCTCC
CGCTTCCTTGGACCACGAGGCACCATCTCTCCAGGAGGCTGCCTTAGCAGCAGCGTGCTCCAACAGGCTCTGCAAGCTGCCTTCCTTCAT
CTCCCTGCAGTCCTCGCCGAGCCCAGGAGCCCAGCCCAGGGTCCGGGCCCCTAGGGCCCCCCTCACCAAGGACTCAGGGAAGCCTCTGCA
CATCAAACCACGTCTGTGAGGACCCCAGGGACCGGCCTGCACCTACCTCAGACCCTCATCCTTGGAGAGGAAAGAGGCTCTGTCCACCAC
TCTACCCCACAGGAGGGCCGCCCGCCACCAAGCCTCACCTGGGGGCCACAGGGACACTGCTCTGCCTGCCTGGCCCTCAACCTTCCATGA
CCAGCGTGTGCGCAGGGCCTGGTCTTCCTCCCCCAAGCCAGGCCCCTGTCCCCACCCCACCACCTTCCAGGGTGCCAGGCAGGGCTGGCC
TCCAGGCCTGTCCCCGACTGCCATTGGCAACAGTGGCCCTGCAGCCCCCAGCCCTCCCCACCCAGGTTTTCGGCCCAGTGAAGAGGCCAC

>In-frame_ENST00000507469_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(amino acids)=403AA_start in transcript=67_stop in transcript=1278
MRDPRRLRGKTRRRRRRMSLQSAQYLRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTG
RLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEK
MPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGP
SDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNR

--------------------------------------------------------------
>In-frame_ENST00000515829_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(transcript)=1656nt_BP=123nt
CGGCCGCCAGCACCCGCGGTGCCGCGGGGCCGCTCCGAGGAGCCTGAGAGACCCACGGAGGCTTCGCGGGAAGACGCGGCGGCGGCGGCG
GAGGATGAGCCTGCAGAGCGCGCAGTACCTCCGGTCCCTGGTGCTGAACCGCCTGCGTCCAGTTGCCAGCGGGGGTGGGAAAGCCCAACC
GGGCTCCCCTTGGTGGCGGAGCAAAGGCTACCGCTGCATCGGAGGGGTCCTCTACAAAGTATCTGCCAACAAGCTCTCCAAGACCTCCGG
CCAGCCCAGTGATGCGGGCAGCAGGCCCCTCCTGCGCACAGGCCGGCTGGATCCTGCAGGCAGCTGTAGCCGTTCCCTGGCCAGCCGGGC
AGTGCAGCGCAGCCTGGCCATCATCCGGCAGGCGCGGCAGCGCAGGGAGAAGAGGAAGGAGTACTGCATGTACTACAACCGCTTCGGCAG
GTGCAACCGTGGCGAGCGCTGCCCCTACATCCACGATCCCGAGAAGGTGGCCGTGTGCACCAGGTTTGTCCGGGGCACCTGCAAGAAAAC
GGATGGGACCTGCCCCTTCTCCCACCATGTGTCCAAGGAGAAGATGCCGGTGTGCTCCTACTTCCTGAAGGGCATCTGCAGCAACAGCAA
CTGTCCCTATAGCCACGTGTACGTGTCCCGCAAGGCCGAGGTCTGCAGCGACTTCCTCAAAGGCTACTGCCCCCTGGGTGCAAAGTGCAA
GAAGAAACACACGCTGCTGTGCCCCGACTTTGCCCGCAGGGGGGCGTGTCCCCGCGGCGCCCAGTGCCAGCTGCTCCACCGTACCCAGAA
ACGCCACAGTCGGCGGGCAGCCACGTCCCCCGCCCCAGGGCCCAGCGACGCAACCGCCAGGAGCAGGGTCTCGGCCAGCCACGGGCCCAG
GAAGCCTTCAGCATCCCAGCGCCCCACCAGGCAGACGCCCAGCTCGGCTGCCCTCACTGCGGCTGCCGTGGCTGCACCTCCCCACTGCCC
AGGGGGGTCAGCCTCTCCCTCATCCTCGAAGGCTTCCTCCTCCTCCTCCTCCTCCTCATCCCCTCCCGCTTCCTTGGACCACGAGGCACC
ATCTCTCCAGGAGGCTGCCTTAGCAGCAGCGTGCTCCAACAGGCTCTGCAAGCTGCCTTCCTTCATCTCCCTGCAGTCCTCGCCGAGCCC
AGGAGCCCAGCCCAGGGTCCGGGCCCCTAGGGCCCCCCTCACCAAGGACTCAGGGAAGCCTCTGCACATCAAACCACGTCTGTGAGGACC
CCAGGGACCGGCCTGCACCTACCTCAGACCCTCATCCTTGGAGAGGAAAGAGGCTCTGTCCACCACTCTACCCCACAGGAGGGCCGCCCG
CCACCAAGCCTCACCTGGGGGCCACAGGGACACTGCTCTGCCTGCCTGGCCCTCAACCTTCCATGACCAGCGTGTGCGCAGGGCCTGGTC
TTCCTCCCCCAAGCCAGGCCCCTGTCCCCACCCCACCACCTTCCAGGGTGCCAGGCAGGGCTGGCCTCCAGGCCTGTCCCCGACTGCCAT
TGGCAACAGTGGCCCTGCAGCCCCCAGCCCTCCCCACCCAGGTTTTCGGCCCAGTGAAGAGGCCACTGGCCAGGCCTCCCAGGCAGGTGT

>In-frame_ENST00000515829_ENST00000262577_TCGA-GJ-A6C0_SMG7_chr1_183441784_+_ZC3H3_chr8_144557755_length(amino acids)=403AA_start in transcript=43_stop in transcript=1254
MRDPRRLRGKTRRRRRRMSLQSAQYLRSLVLNRLRPVASGGGKAQPGSPWWRSKGYRCIGGVLYKVSANKLSKTSGQPSDAGSRPLLRTG
RLDPAGSCSRSLASRAVQRSLAIIRQARQRREKRKEYCMYYNRFGRCNRGERCPYIHDPEKVAVCTRFVRGTCKKTDGTCPFSHHVSKEK
MPVCSYFLKGICSNSNCPYSHVYVSRKAEVCSDFLKGYCPLGAKCKKKHTLLCPDFARRGACPRGAQCQLLHRTQKRHSRRAATSPAPGP
SDATARSRVSASHGPRKPSASQRPTRQTPSSAALTAAAVAAPPHCPGGSASPSSSKASSSSSSSSSPPASLDHEAPSLQEAALAAACSNR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMG7-ZC3H3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMG7-ZC3H3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMG7-ZC3H3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource