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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMUG1-PPP2R5A (FusionGDB2 ID:83719)

Fusion Gene Summary for SMUG1-PPP2R5A

check button Fusion gene summary
Fusion gene informationFusion gene name: SMUG1-PPP2R5A
Fusion gene ID: 83719
HgeneTgene
Gene symbol

SMUG1

PPP2R5A

Gene ID

23583

5525

Gene namesingle-strand-selective monofunctional uracil-DNA glycosylase 1protein phosphatase 2 regulatory subunit B'alpha
SynonymsFDG|HMUDG|UNG3B56A|B56alpha|PR61A
Cytomap

12q13.13

1q32.3

Type of geneprotein-codingprotein-coding
Descriptionsingle-strand selective monofunctional uracil DNA glycosylaseserine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoformPP2A B subunit isoform B'-alphaPP2A B subunit isoform B56-alphaPP2A B subunit isoform PR61-alphaPP2A B subunit isoform R5-alphaPP2A, B subunit, B' alpha isoformPP2A, B su
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000508394, ENST00000506595, 
ENST00000514685, ENST00000505128, 
ENST00000337581, ENST00000513838, 
ENST00000243112, ENST00000505662, 
ENST00000401977, ENST00000514196, 
ENST00000261461, ENST00000537030, 
ENST00000498129, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 7 X 5=245
# samples 410
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(10/245*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMUG1 [Title/Abstract] AND PPP2R5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMUG1(54576288)-PPP2R5A(212506839), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMUG1

GO:0006284

base-excision repair

12161446

TgenePPP2R5A

GO:0006470

protein dephosphorylation

24157919


check buttonFusion gene breakpoints across SMUG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPP2R5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-XJ-A83H-01ASMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
ChimerDB4PRADTCGA-XJ-A83H-01ASMUG1chr12

54576288

-PPP2R5Achr1

212506839

+


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Fusion Gene ORF analysis for SMUG1-PPP2R5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000508394ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000508394ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3UTRENST00000508394ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000506595ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000506595ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
5CDS-3UTRENST00000506595ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
In-frameENST00000514685ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
In-frameENST00000514685ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
5CDS-3UTRENST00000514685ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000505128ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000505128ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3UTRENST00000505128ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000337581ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000337581ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3UTRENST00000337581ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
In-frameENST00000513838ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
In-frameENST00000513838ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
5CDS-3UTRENST00000513838ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000243112ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000243112ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
5CDS-3UTRENST00000243112ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000505662ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000505662ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3UTRENST00000505662ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000401977ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3CDSENST00000401977ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
intron-3UTRENST00000401977ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000514196ENST00000261461SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
Frame-shiftENST00000514196ENST00000537030SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+
5CDS-3UTRENST00000514196ENST00000498129SMUG1chr12

54576288

-PPP2R5Achr1

212506839

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000514685SMUG1chr1254576288-ENST00000261461PPP2R5Achr1212506839+29027313261813495
ENST00000514685SMUG1chr1254576288-ENST00000537030PPP2R5Achr1212506839+19667313261813495
ENST00000513838SMUG1chr1254576288-ENST00000261461PPP2R5Achr1212506839+30008294241911495
ENST00000513838SMUG1chr1254576288-ENST00000537030PPP2R5Achr1212506839+20648294241911495

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000514685ENST00000261461SMUG1chr1254576288-PPP2R5Achr1212506839+0.000592790.9994072
ENST00000514685ENST00000537030SMUG1chr1254576288-PPP2R5Achr1212506839+0.0016469780.998353
ENST00000513838ENST00000261461SMUG1chr1254576288-PPP2R5Achr1212506839+0.0007745760.9992254
ENST00000513838ENST00000537030SMUG1chr1254576288-PPP2R5Achr1212506839+0.0022878010.99771225

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Fusion Genomic Features for SMUG1-PPP2R5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMUG1chr1254576287-PPP2R5Achr1212506838+0.0006269430.99937314
SMUG1chr1254576287-PPP2R5Achr1212506838+0.0006269430.99937314

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMUG1-PPP2R5A


check button Go to

FGviewer for the breakpoints of chr12:54576288-chr1:212506839

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMUG1chr12:54576288chr1:212506839ENST00000243112-34173_187135.0178.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000337581-14173_1870271.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000401977-13173_1870271.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000506595-34173_187135.0178.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000508394-13173_1870271.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000513838-56173_187135.0178.0RegionDNA binding
HgeneSMUG1chr12:54576288chr1:212506839ENST00000514685-45173_187135.0178.0RegionDNA binding
TgenePPP2R5Achr12:54576288chr1:212506839ENST000002614611132_5126.0487.0Compositional biasNote=Poly-Ser
TgenePPP2R5Achr12:54576288chr1:212506839ENST000005370301132_569.0430.0Compositional biasNote=Poly-Ser


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Fusion Gene Sequence for SMUG1-PPP2R5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000514685_ENST00000261461_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(transcript)=2902nt_BP=731nt
AGGGGGCTGGGAATCCGGGACTGTGGGGGCAAGTTGACGGCTCCCAGGGTCGTCGGGGCTGAGCCGAGAGGGTGGTTAGAATTTCTATAT
TTTGGGGTCCCTCCCTCCGTATGGGGTAAGACTCAGTGCAGGGAGAGCCCAGCCTATGAAACCGCCTGGGAGGTCTGCAGGATCAAGGCT
TTCCAGTCGGCCGGAGCCAGCGGGCGCCCCCGGAGGTTTTCAGATTATGAGCTTACAGAAAGCCTGGCCTACATTTTACTCTTTTTGGAT
TTCTTCCTCATCAAGAGACTGCTGCAGTGCCTGTCATGTGACAGCGGCATGGACATATGCCCCAGGCTTTCCTGCTGGGGTCCATCCATG
AGCCTGCAGGTGCCCTCATGGAGCCCCAGCCCTGCCCTGGAAGCTTGGCTGAGAGCTTCCTGGAGGAGGAGCTTCGGCTCAATGCTGAGC
TGAGCCAGCTGCAGTTTTCGGAGCCTGTGGGCATCATCTACAATCCCGTGGAGTATGCATGGGAGCCACATCGCAACTACGTGACTCGCT
ACTGCCAGGGCCCCAAGGAAGTACTCTTCCTGGGCATGAACCCTGGACCTTTTGGCATGGCCCAGACTGGGGTGCCCTTTGGGGAAGTAA
GCATGGTCCGGGACTGGTTGGGCATTGTGGGGCCTGTGCTGACCCCTCCCCAAGAGCATCCTAAACGACCAGTGCTGGGACTGGAGTGCC
CACAGTCAGAAATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGATAATCCAGATTTTGATCCAGAAGAGGATGAACCCACGCTTG
AGGCCTCTTGGCCTCACATACAGTTGGTATATGAATTCTTCTTGAGATTTTTGGAGAGCCCTGATTTCCAGCCTAGCATTGCAAAACGAT
ACATTGATCAGAAATTCGTACAACAGCTCCTGGAGCTTTTTGATAGTGAAGATCCCAGAGAACGTGACTTCCTGAAGACTGTTCTGCACC
GAATTTATGGGAAATTTCTTGGATTAAGAGCATTCATCAGAAAACAAATTAACAACATTTTCCTCAGGTTTATATATGAAACAGAACATT
TCAATGGTGTTGCTGAACTTCTTGAAATATTAGGAAGTATTATCAATGGCTTTGCATTGCCACTGAAAGCAGAACATAAACAATTTCTAA
TGAAGGTTCTTATTCCTATGCATACTGCAAAAGGATTAGCTTTGTTTCATGCTCAGCTAGCATATTGTGTTGTACAGTTCCTGGAGAAAG
ATACAACACTAACAGAGCCAGTGATCAGAGGACTGCTGAAATTTTGGCCAAAAACCTGCAGTCAGAAAGAGGTGATGTTTTTAGGAGAAA
TTGAAGAAATCTTAGATGTCATTGAACCAACACAGTTCAAAAAAATTGAAGAGCCACTTTTCAAGCAGATATCCAAGTGTGTATCCAGTT
CTCATTTTCAGGTTGCAGAAAGGGCATTGTACTTCTGGAATAACGAATATATTCTTAGTTTGATTGAGGAGAACATTGATAAAATTCTGC
CAATTATGTTTGCCAGTTTGTACAAAATTTCCAAAGAACACTGGAATCCGACCATTGTAGCACTGGTATACAATGTGCTGAAAACCCTAA
TGGAAATGAATGGCAAGCTTTTCGATGACCTTACTAGCTCATACAAAGCTGAAAGACAGAGAGAGAAAAAGAAGGAATTGGAACGTGAAG
AATTATGGAAAAAATTAGAGGAGCTAAAGCTAAAGAAAGCTCTAGAAAAACAGAATAGTGCTTACAACATGCACAGTATTCTCAGCAATA
CAAGTGCCGAATAAAAAAAAAGCCTCCCACCTCTGCCGGATAGGCAGAGTTTTGTATGCTTTTTTGAAATATGTAAAAATTACAAAACAA
ACCTCATCAGTATAATATAATTAAAAGGCCAATTTTTTCTGGCAACTGTAAATGGAAAAATATATGGACTAAACGTAGCCCTGTGCTGTA
TCATGGCCATAGTATATTGTAACCTTTGTCTAATCATTGGATTTATTGTGTCACTTCTGAAGTTTCACAGAAATGAATGAATTTTATCAT
CTATGATATGAGTGAGATAATTATGGGAGTGGTAAGAATTATGACTTGAATTCTTCTTTGATTGTGTTGCACATAGATATGGTAGTCTGC
TCTGTATATTTTTCCCTTTTATAATGTGCTTTTCACACTGCTGCAAACCTTAGTTACATCCTAGGAAAAAATACTTCCTAAAATAAAACT
AAGGTATCATCCTTACCCTTCTCTTTGTCTCACCCAGAAATATGATGGGGGGAATTACCTGCCCTAACCCCTCCCTCAATAAATACATTA
CTGTACTCTGGAATTTAGGCAAAACCTTAAATCTCCAGGCTTTTTAAAGCACAAAATATAAATAAAAGCTGGGAAAGTAAACCAAAATTC
TTCAGATTGTTCCTCATGAATATCCCCCTTCCTCTGCAATTCTCCAGAGTGGTAACAGATGGGTAGAGGCAGCTCAGGTGAATTACCCAG
CTTGCCTCTCAATTCATTCCTCCTCTTCCTCTCAAAGGCTGAAGGCAGGGCCTTTCCAGTCCTCACAACCTGTCCTTCACCTAGTCCCTC
CTGACCCAGGGATGGAGGCTTTGAGTCCCACAGTGTGGTGATACAGAGCACTAGTTGTCACTGCCTGGCTTTATTTAAAGGAACTGCAGT
AGGCTTCCTCTGTAGAGCTCTGAAAAGGTTGACTATATAGAGGTCTTGTATGTTTTTACTTGGTCAAGTATTTCTCACATCTTTTGTTAT
CAGAGTACCATTCCAATCTCTTAACTTGCAGTTGTGTGGAAAACTGTTTTGTAATGAAAGATCTTCATTGGGGGATTGAGCAGCATTTAA

>In-frame_ENST00000514685_ENST00000261461_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(amino acids)=495AA_start in transcript=326_stop in transcript=1813
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFG
MAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLE
SPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFA
LPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEP
LFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAER

--------------------------------------------------------------
>In-frame_ENST00000514685_ENST00000537030_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(transcript)=1966nt_BP=731nt
AGGGGGCTGGGAATCCGGGACTGTGGGGGCAAGTTGACGGCTCCCAGGGTCGTCGGGGCTGAGCCGAGAGGGTGGTTAGAATTTCTATAT
TTTGGGGTCCCTCCCTCCGTATGGGGTAAGACTCAGTGCAGGGAGAGCCCAGCCTATGAAACCGCCTGGGAGGTCTGCAGGATCAAGGCT
TTCCAGTCGGCCGGAGCCAGCGGGCGCCCCCGGAGGTTTTCAGATTATGAGCTTACAGAAAGCCTGGCCTACATTTTACTCTTTTTGGAT
TTCTTCCTCATCAAGAGACTGCTGCAGTGCCTGTCATGTGACAGCGGCATGGACATATGCCCCAGGCTTTCCTGCTGGGGTCCATCCATG
AGCCTGCAGGTGCCCTCATGGAGCCCCAGCCCTGCCCTGGAAGCTTGGCTGAGAGCTTCCTGGAGGAGGAGCTTCGGCTCAATGCTGAGC
TGAGCCAGCTGCAGTTTTCGGAGCCTGTGGGCATCATCTACAATCCCGTGGAGTATGCATGGGAGCCACATCGCAACTACGTGACTCGCT
ACTGCCAGGGCCCCAAGGAAGTACTCTTCCTGGGCATGAACCCTGGACCTTTTGGCATGGCCCAGACTGGGGTGCCCTTTGGGGAAGTAA
GCATGGTCCGGGACTGGTTGGGCATTGTGGGGCCTGTGCTGACCCCTCCCCAAGAGCATCCTAAACGACCAGTGCTGGGACTGGAGTGCC
CACAGTCAGAAATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGATAATCCAGATTTTGATCCAGAAGAGGATGAACCCACGCTTG
AGGCCTCTTGGCCTCACATACAGTTGGTATATGAATTCTTCTTGAGATTTTTGGAGAGCCCTGATTTCCAGCCTAGCATTGCAAAACGAT
ACATTGATCAGAAATTCGTACAACAGCTCCTGGAGCTTTTTGATAGTGAAGATCCCAGAGAACGTGACTTCCTGAAGACTGTTCTGCACC
GAATTTATGGGAAATTTCTTGGATTAAGAGCATTCATCAGAAAACAAATTAACAACATTTTCCTCAGGTTTATATATGAAACAGAACATT
TCAATGGTGTTGCTGAACTTCTTGAAATATTAGGAAGTATTATCAATGGCTTTGCATTGCCACTGAAAGCAGAACATAAACAATTTCTAA
TGAAGGTTCTTATTCCTATGCATACTGCAAAAGGATTAGCTTTGTTTCATGCTCAGCTAGCATATTGTGTTGTACAGTTCCTGGAGAAAG
ATACAACACTAACAGAGCCAGTGATCAGAGGACTGCTGAAATTTTGGCCAAAAACCTGCAGTCAGAAAGAGGTGATGTTTTTAGGAGAAA
TTGAAGAAATCTTAGATGTCATTGAACCAACACAGTTCAAAAAAATTGAAGAGCCACTTTTCAAGCAGATATCCAAGTGTGTATCCAGTT
CTCATTTTCAGGTTGCAGAAAGGGCATTGTACTTCTGGAATAACGAATATATTCTTAGTTTGATTGAGGAGAACATTGATAAAATTCTGC
CAATTATGTTTGCCAGTTTGTACAAAATTTCCAAAGAACACTGGAATCCGACCATTGTAGCACTGGTATACAATGTGCTGAAAACCCTAA
TGGAAATGAATGGCAAGCTTTTCGATGACCTTACTAGCTCATACAAAGCTGAAAGACAGAGAGAGAAAAAGAAGGAATTGGAACGTGAAG
AATTATGGAAAAAATTAGAGGAGCTAAAGCTAAAGAAAGCTCTAGAAAAACAGAATAGTGCTTACAACATGCACAGTATTCTCAGCAATA
CAAGTGCCGAATAAAAAAAAAGCCTCCCACCTCTGCCGGATAGGCAGAGTTTTGTATGCTTTTTTGAAATATGTAAAAATTACAAAACAA

>In-frame_ENST00000514685_ENST00000537030_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(amino acids)=495AA_start in transcript=326_stop in transcript=1813
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFG
MAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLE
SPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFA
LPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEP
LFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAER

--------------------------------------------------------------
>In-frame_ENST00000513838_ENST00000261461_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(transcript)=3000nt_BP=829nt
GGACCAGGTGAGGAAGTAGGGGGCTGGGAATCCGGGACTGTGGGGGCAAGTTGACGGCTCCCAGGGTCGTCGGGGCTGAGCCGAGAGGGT
GGTTAGAATTTCTATATTTTGGGGTCCCTCCCTCCGTATGGGGTAAGACTCAGTGCAGGGAGAGCCCAGCCTATGAAACCGCCTGGGAGG
TCTGCAGGATCAAGGCTTTCCAGTCGGCCGGAGCCAGCGGGCGCCCCCGGAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACTGCAGCC
TCCGCCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCAGATTATGAGCTTACAGAAAGCCTGGCCTACATTTTACTCT
TTTTGGATTTCTTCCTCATCAAGAGACTGCTGCAGTGCCTGTCATGTGACAGCGGCATGGACATATGCCCCAGGCTTTCCTGCTGGGGTC
CATCCATGAGCCTGCAGGTGCCCTCATGGAGCCCCAGCCCTGCCCTGGAAGCTTGGCTGAGAGCTTCCTGGAGGAGGAGCTTCGGCTCAA
TGCTGAGCTGAGCCAGCTGCAGTTTTCGGAGCCTGTGGGCATCATCTACAATCCCGTGGAGTATGCATGGGAGCCACATCGCAACTACGT
GACTCGCTACTGCCAGGGCCCCAAGGAAGTACTCTTCCTGGGCATGAACCCTGGACCTTTTGGCATGGCCCAGACTGGGGTGCCCTTTGG
GGAAGTAAGCATGGTCCGGGACTGGTTGGGCATTGTGGGGCCTGTGCTGACCCCTCCCCAAGAGCATCCTAAACGACCAGTGCTGGGACT
GGAGTGCCCACAGTCAGAAATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGATAATCCAGATTTTGATCCAGAAGAGGATGAACC
CACGCTTGAGGCCTCTTGGCCTCACATACAGTTGGTATATGAATTCTTCTTGAGATTTTTGGAGAGCCCTGATTTCCAGCCTAGCATTGC
AAAACGATACATTGATCAGAAATTCGTACAACAGCTCCTGGAGCTTTTTGATAGTGAAGATCCCAGAGAACGTGACTTCCTGAAGACTGT
TCTGCACCGAATTTATGGGAAATTTCTTGGATTAAGAGCATTCATCAGAAAACAAATTAACAACATTTTCCTCAGGTTTATATATGAAAC
AGAACATTTCAATGGTGTTGCTGAACTTCTTGAAATATTAGGAAGTATTATCAATGGCTTTGCATTGCCACTGAAAGCAGAACATAAACA
ATTTCTAATGAAGGTTCTTATTCCTATGCATACTGCAAAAGGATTAGCTTTGTTTCATGCTCAGCTAGCATATTGTGTTGTACAGTTCCT
GGAGAAAGATACAACACTAACAGAGCCAGTGATCAGAGGACTGCTGAAATTTTGGCCAAAAACCTGCAGTCAGAAAGAGGTGATGTTTTT
AGGAGAAATTGAAGAAATCTTAGATGTCATTGAACCAACACAGTTCAAAAAAATTGAAGAGCCACTTTTCAAGCAGATATCCAAGTGTGT
ATCCAGTTCTCATTTTCAGGTTGCAGAAAGGGCATTGTACTTCTGGAATAACGAATATATTCTTAGTTTGATTGAGGAGAACATTGATAA
AATTCTGCCAATTATGTTTGCCAGTTTGTACAAAATTTCCAAAGAACACTGGAATCCGACCATTGTAGCACTGGTATACAATGTGCTGAA
AACCCTAATGGAAATGAATGGCAAGCTTTTCGATGACCTTACTAGCTCATACAAAGCTGAAAGACAGAGAGAGAAAAAGAAGGAATTGGA
ACGTGAAGAATTATGGAAAAAATTAGAGGAGCTAAAGCTAAAGAAAGCTCTAGAAAAACAGAATAGTGCTTACAACATGCACAGTATTCT
CAGCAATACAAGTGCCGAATAAAAAAAAAGCCTCCCACCTCTGCCGGATAGGCAGAGTTTTGTATGCTTTTTTGAAATATGTAAAAATTA
CAAAACAAACCTCATCAGTATAATATAATTAAAAGGCCAATTTTTTCTGGCAACTGTAAATGGAAAAATATATGGACTAAACGTAGCCCT
GTGCTGTATCATGGCCATAGTATATTGTAACCTTTGTCTAATCATTGGATTTATTGTGTCACTTCTGAAGTTTCACAGAAATGAATGAAT
TTTATCATCTATGATATGAGTGAGATAATTATGGGAGTGGTAAGAATTATGACTTGAATTCTTCTTTGATTGTGTTGCACATAGATATGG
TAGTCTGCTCTGTATATTTTTCCCTTTTATAATGTGCTTTTCACACTGCTGCAAACCTTAGTTACATCCTAGGAAAAAATACTTCCTAAA
ATAAAACTAAGGTATCATCCTTACCCTTCTCTTTGTCTCACCCAGAAATATGATGGGGGGAATTACCTGCCCTAACCCCTCCCTCAATAA
ATACATTACTGTACTCTGGAATTTAGGCAAAACCTTAAATCTCCAGGCTTTTTAAAGCACAAAATATAAATAAAAGCTGGGAAAGTAAAC
CAAAATTCTTCAGATTGTTCCTCATGAATATCCCCCTTCCTCTGCAATTCTCCAGAGTGGTAACAGATGGGTAGAGGCAGCTCAGGTGAA
TTACCCAGCTTGCCTCTCAATTCATTCCTCCTCTTCCTCTCAAAGGCTGAAGGCAGGGCCTTTCCAGTCCTCACAACCTGTCCTTCACCT
AGTCCCTCCTGACCCAGGGATGGAGGCTTTGAGTCCCACAGTGTGGTGATACAGAGCACTAGTTGTCACTGCCTGGCTTTATTTAAAGGA
ACTGCAGTAGGCTTCCTCTGTAGAGCTCTGAAAAGGTTGACTATATAGAGGTCTTGTATGTTTTTACTTGGTCAAGTATTTCTCACATCT
TTTGTTATCAGAGTACCATTCCAATCTCTTAACTTGCAGTTGTGTGGAAAACTGTTTTGTAATGAAAGATCTTCATTGGGGGATTGAGCA

>In-frame_ENST00000513838_ENST00000261461_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(amino acids)=495AA_start in transcript=424_stop in transcript=1911
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFG
MAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLE
SPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFA
LPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEP
LFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAER

--------------------------------------------------------------
>In-frame_ENST00000513838_ENST00000537030_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(transcript)=2064nt_BP=829nt
GGACCAGGTGAGGAAGTAGGGGGCTGGGAATCCGGGACTGTGGGGGCAAGTTGACGGCTCCCAGGGTCGTCGGGGCTGAGCCGAGAGGGT
GGTTAGAATTTCTATATTTTGGGGTCCCTCCCTCCGTATGGGGTAAGACTCAGTGCAGGGAGAGCCCAGCCTATGAAACCGCCTGGGAGG
TCTGCAGGATCAAGGCTTTCCAGTCGGCCGGAGCCAGCGGGCGCCCCCGGAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACTGCAGCC
TCCGCCTCCCGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCAGATTATGAGCTTACAGAAAGCCTGGCCTACATTTTACTCT
TTTTGGATTTCTTCCTCATCAAGAGACTGCTGCAGTGCCTGTCATGTGACAGCGGCATGGACATATGCCCCAGGCTTTCCTGCTGGGGTC
CATCCATGAGCCTGCAGGTGCCCTCATGGAGCCCCAGCCCTGCCCTGGAAGCTTGGCTGAGAGCTTCCTGGAGGAGGAGCTTCGGCTCAA
TGCTGAGCTGAGCCAGCTGCAGTTTTCGGAGCCTGTGGGCATCATCTACAATCCCGTGGAGTATGCATGGGAGCCACATCGCAACTACGT
GACTCGCTACTGCCAGGGCCCCAAGGAAGTACTCTTCCTGGGCATGAACCCTGGACCTTTTGGCATGGCCCAGACTGGGGTGCCCTTTGG
GGAAGTAAGCATGGTCCGGGACTGGTTGGGCATTGTGGGGCCTGTGCTGACCCCTCCCCAAGAGCATCCTAAACGACCAGTGCTGGGACT
GGAGTGCCCACAGTCAGAAATCAGTGCTAACATCTTCCGTACACTTCCTCCAAGTGATAATCCAGATTTTGATCCAGAAGAGGATGAACC
CACGCTTGAGGCCTCTTGGCCTCACATACAGTTGGTATATGAATTCTTCTTGAGATTTTTGGAGAGCCCTGATTTCCAGCCTAGCATTGC
AAAACGATACATTGATCAGAAATTCGTACAACAGCTCCTGGAGCTTTTTGATAGTGAAGATCCCAGAGAACGTGACTTCCTGAAGACTGT
TCTGCACCGAATTTATGGGAAATTTCTTGGATTAAGAGCATTCATCAGAAAACAAATTAACAACATTTTCCTCAGGTTTATATATGAAAC
AGAACATTTCAATGGTGTTGCTGAACTTCTTGAAATATTAGGAAGTATTATCAATGGCTTTGCATTGCCACTGAAAGCAGAACATAAACA
ATTTCTAATGAAGGTTCTTATTCCTATGCATACTGCAAAAGGATTAGCTTTGTTTCATGCTCAGCTAGCATATTGTGTTGTACAGTTCCT
GGAGAAAGATACAACACTAACAGAGCCAGTGATCAGAGGACTGCTGAAATTTTGGCCAAAAACCTGCAGTCAGAAAGAGGTGATGTTTTT
AGGAGAAATTGAAGAAATCTTAGATGTCATTGAACCAACACAGTTCAAAAAAATTGAAGAGCCACTTTTCAAGCAGATATCCAAGTGTGT
ATCCAGTTCTCATTTTCAGGTTGCAGAAAGGGCATTGTACTTCTGGAATAACGAATATATTCTTAGTTTGATTGAGGAGAACATTGATAA
AATTCTGCCAATTATGTTTGCCAGTTTGTACAAAATTTCCAAAGAACACTGGAATCCGACCATTGTAGCACTGGTATACAATGTGCTGAA
AACCCTAATGGAAATGAATGGCAAGCTTTTCGATGACCTTACTAGCTCATACAAAGCTGAAAGACAGAGAGAGAAAAAGAAGGAATTGGA
ACGTGAAGAATTATGGAAAAAATTAGAGGAGCTAAAGCTAAAGAAAGCTCTAGAAAAACAGAATAGTGCTTACAACATGCACAGTATTCT
CAGCAATACAAGTGCCGAATAAAAAAAAAGCCTCCCACCTCTGCCGGATAGGCAGAGTTTTGTATGCTTTTTTGAAATATGTAAAAATTA

>In-frame_ENST00000513838_ENST00000537030_TCGA-XJ-A83H-01A_SMUG1_chr12_54576288_-_PPP2R5A_chr1_212506839_length(amino acids)=495AA_start in transcript=424_stop in transcript=1911
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFG
MAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLE
SPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFA
LPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEP
LFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMUG1-PPP2R5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMUG1-PPP2R5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMUG1-PPP2R5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPP2R5AC0013990Pathological accumulation of air in tissues1CTD_human