FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SMURF2-NGFR (FusionGDB2 ID:83754)

Fusion Gene Summary for SMURF2-NGFR

check button Fusion gene summary
Fusion gene informationFusion gene name: SMURF2-NGFR
Fusion gene ID: 83754
HgeneTgene
Gene symbol

SMURF2

NGFR

Gene ID

64750

4804

Gene nameSMAD specific E3 ubiquitin protein ligase 2nerve growth factor receptor
Synonyms-CD271|Gp80-LNGFR|TNFRSF16|p75(NTR)|p75NTR
Cytomap

17q23.3-q24.1

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SMURF2E3 ubiquitin ligase SMURF2HECT-type E3 ubiquitin transferase SMURF2SMAD ubiquitination regulatory factor 2hSMURF2tumor necrosis factor receptor superfamily member 16NGF receptorTNFR superfamily, member 16low affinity neurotrophin receptor p75NTRlow-affinity nerve growth factor receptorp75 ICD
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262435, ENST00000578200, 
ENST00000172229, ENST00000504201, 
Fusion gene scores* DoF score18 X 11 X 13=25745 X 3 X 4=60
# samples 248
** MAII scorelog2(24/2574*10)=-3.42290574261218
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMURF2 [Title/Abstract] AND NGFR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMURF2(62657947)-NGFR(47579425), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMURF2

GO:0006511

ubiquitin-dependent protein catabolic process

14755250

HgeneSMURF2

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

19255252

HgeneSMURF2

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

19122240

HgeneSMURF2

GO:1901165

positive regulation of trophoblast cell migration

19255252

TgeneNGFR

GO:0007266

Rho protein signal transduction

16712417

TgeneNGFR

GO:1900182

positive regulation of protein localization to nucleus

26268439

TgeneNGFR

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

26268439

TgeneNGFR

GO:1904646

cellular response to amyloid-beta

11927634


check buttonFusion gene breakpoints across SMURF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NGFR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A250-01ASMURF2chr17

62657947

-NGFRchr17

47579425

+
ChimerDB4BRCATCGA-AR-A250SMURF2chr17

62657946

-NGFRchr17

47579424

+
ChimerDB4BRCATCGA-AR-A250-01ASMURF2chr17

62657947

-NGFRchr17

47579425

+
ChimerDB4BRCATCGA-AR-A250-01ASMURF2chr17

62657947

-NGFRchr17

47579425

+


Top

Fusion Gene ORF analysis for SMURF2-NGFR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262435ENST00000172229SMURF2chr17

62657947

-NGFRchr17

47579425

+
5CDS-5UTRENST00000262435ENST00000504201SMURF2chr17

62657947

-NGFRchr17

47579425

+
intron-3CDSENST00000578200ENST00000172229SMURF2chr17

62657947

-NGFRchr17

47579425

+
intron-5UTRENST00000578200ENST00000504201SMURF2chr17

62657947

-NGFRchr17

47579425

+
In-frameENST00000262435ENST00000172229SMURF2chr17

62657946

-NGFRchr17

47579424

+
5CDS-5UTRENST00000262435ENST00000504201SMURF2chr17

62657946

-NGFRchr17

47579424

+
intron-3CDSENST00000578200ENST00000172229SMURF2chr17

62657946

-NGFRchr17

47579424

+
intron-5UTRENST00000578200ENST00000504201SMURF2chr17

62657946

-NGFRchr17

47579424

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262435SMURF2chr1762657947-ENST00000172229NGFRchr1747579425+34662401697222491
ENST00000262435SMURF2chr1762657946-ENST00000172229NGFRchr1747579424+34662401697222491

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262435ENST00000172229SMURF2chr1762657947-NGFRchr1747579425+0.0356684140.9643316
ENST00000262435ENST00000172229SMURF2chr1762657946-NGFRchr1747579424+0.0356684140.9643316

Top

Fusion Genomic Features for SMURF2-NGFR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMURF2chr1762657946-NGFRchr1747579424+2.44E-101
SMURF2chr1762657946-NGFRchr1747579424+2.44E-101
SMURF2chr1762657946-NGFRchr1747579424+2.44E-101
SMURF2chr1762657946-NGFRchr1747579424+2.44E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SMURF2-NGFR


check button Go to

FGviewer for the breakpoints of chr17:62657947-chr17:47579425

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906197_24822.0428.0Compositional biasNote=Ser/Thr-rich
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906197_24822.0428.0Compositional biasNote=Ser/Thr-rich
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906344_42122.0428.0DomainDeath
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906344_42122.0428.0DomainDeath
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906108_14622.0428.0RepeatNote=TNFR-Cys 3
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906148_18822.0428.0RepeatNote=TNFR-Cys 4
TgeneNGFRchr17:62657946chr17:47579424ENST000001722290631_6422.0428.0RepeatNote=TNFR-Cys 1
TgeneNGFRchr17:62657946chr17:47579424ENST000001722290666_10722.0428.0RepeatNote=TNFR-Cys 2
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906108_14622.0428.0RepeatNote=TNFR-Cys 3
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906148_18822.0428.0RepeatNote=TNFR-Cys 4
TgeneNGFRchr17:62657947chr17:47579425ENST000001722290631_6422.0428.0RepeatNote=TNFR-Cys 1
TgeneNGFRchr17:62657947chr17:47579425ENST000001722290666_10722.0428.0RepeatNote=TNFR-Cys 2
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906273_42722.0428.0Topological domainCytoplasmic
TgeneNGFRchr17:62657946chr17:47579424ENST000001722290629_25022.0428.0Topological domainExtracellular
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906273_42722.0428.0Topological domainCytoplasmic
TgeneNGFRchr17:62657947chr17:47579425ENST000001722290629_25022.0428.0Topological domainExtracellular
TgeneNGFRchr17:62657946chr17:47579424ENST0000017222906251_27222.0428.0TransmembraneHelical
TgeneNGFRchr17:62657947chr17:47579425ENST0000017222906251_27222.0428.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMURF2chr17:62657946chr17:47579424ENST00000262435-119157_19017.333333333333332749.0DomainWW 1
HgeneSMURF2chr17:62657946chr17:47579424ENST00000262435-1191_11917.333333333333332749.0DomainC2
HgeneSMURF2chr17:62657946chr17:47579424ENST00000262435-119414_74817.333333333333332749.0DomainHECT
HgeneSMURF2chr17:62657947chr17:47579425ENST00000262435-119157_19017.333333333333332749.0DomainWW 1
HgeneSMURF2chr17:62657947chr17:47579425ENST00000262435-1191_11917.333333333333332749.0DomainC2
HgeneSMURF2chr17:62657947chr17:47579425ENST00000262435-119414_74817.333333333333332749.0DomainHECT


Top

Fusion Gene Sequence for SMURF2-NGFR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262435_ENST00000172229_TCGA-AR-A250-01A_SMURF2_chr17_62657947_-_NGFR_chr17_47579425_length(transcript)=3466nt_BP=240nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGGTGTCCCTTGGAGGTGCCAAGGAGGCATGC
CCCACAGGCCTGTACACACACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAACCAGACC
GTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTC
CAGAGCATGTCGGCGCCGTGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGGCGCTGC
GAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGC
ACGTATTCCGACGAGGCCAACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGCACACGC
TGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACC
CAGGAGCCTGAGGCACCTCCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAGCCCGTG
GTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTC
AAGAGGTGGAACAGCTGCAAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAACTCCAC
AGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGAC
GGAGGCCTCTACAGCAGCCTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGGCACCTG
GCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACC
CAGGACAGCGCCACACTGGACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAGTCCACT
GCCACATCCCCGGTGTGAGCCCAACCGGGGAGCCCCCGCCCCGCCCCACATTCCGACAACCGATGCTCCAGCCAACCCCTGTGGAGCCCG
CACCCCCACCCTTTGGGGGGGGCCCGCCTGGCAGAACTGAGCTCCTCTGGGCAGGACCTCAGAGTCCAGGCCCCAAAACCACAGCCCTGT
CAGTGCAGCCCGTGTGGCCCCTTCACTTCTGACCACACTTCCTGTCCAGAGAGAGAAGTGCCCCTGCTGCCTCCCCAACCCTGCCCCTGC
CCCGTCACCATCTCAGGCCACCTGCCCCCTTCTCCCACACTGCTAGGTGGGCCAGCCCCTCCCACCACAGCAGGTGTCATATATGGGGGG
CCAACACCAGGGATGGTACTAGGGGGAAGTGACAAGGCCCCAGAGACTCAGAGGGAGGAATCGAGGAACCAGAGCCATGGACTCTACACT
GTGAACTTGGGGAACAAGGGTGGCATCCCAGTGGCCTCAACCCTCCCTCAGCCCCTCTTGCCCCCCACCCCAGCCTAAGATGAAGAGGAT
CGGAGGCTTGTCAGAGCTGGGAGGGGTTTTCGAAGCTCAGCCCACCCCCCTCATTTTGGATATAGGTCAGTGAGGCCCAGGGAGAGGCCA
TGATTCGCCCAAAGCCAGACAGCAACGGGGAGGCCAAGTGCAGGCTGGCACCGCCTTCTCTAAATGAGGGGCCTCAGGTTTGCCTGAGGG
CGAGGGGAGGGTGGCAGGTGACCTTCTGGGAAATGGCTTGAAGCCAAGTCAGCTTTGCCTTCCACGCTGTCTCCAGACCCCCACCCCTTC
CCCACTGCCTGCCCACCCGTGGAGATGGGATGCTTGCCTAGGGCCTGGTCCATGATGGAGTCAGGTTTGGGGTTCGTGGAAAGGGTGCTG
CTTCCCTCTGCCTGTCCCTCTCAGGCATGCCTGTGTGACATCAGTGGCATGGCTCCAGTCTGCTGCCCTCCATCCCGACATGGACCCGGA
GCTAACACTGGCCCCTAGAATCAGCCTAGGGGTCAGGGACCAAGGACCCCTCACCTTGCAACACACAGACACACGCACACACACACACAG
GAGGAGAAATCTCACTTTTCTCCATGAGTTTTTTCTCTTGGGCTGAGACTGGATACTGCCCGGGGCAGCTGCCAGAGAAGCATCGGAGGG
AATTGAGGTCTGCTCGGCCGTCTTCACTCGCCCCCGGGTTTGGCGGGCCAAGGACTGCCGACCGAGGCTGGAGCTGGCGTCTGTCTTCAA
GGGCTTACACGTGGAGGAATGCTCCCCCATCCTCCCCTTCCCTGCAAACATGGGGTTGGCTGGGCCCAGAAGGTTGTGATGAAGAAAAGT
GGGCCAGTGTGGGAATGCGGCAAGAAGGAATTGACTTCGACTGTGACCTGTGGGGATTTCTCCCAGCTCTAGACAACCCTGCAAAGGACT
GTTTTTTCCTGAGCTTGGCCAGAAGGGGGCCATGAGGCCTCAGTGGACTTTCCACCCCCTCCCTGGCCTGTTCTGTTTTGCCTGAAGTTG
GAGTGAGTGTGGCTCCCCTCTATTTAGCATGACAAGCCCCAGGCAGGCTGTGCGCTGACAACCACCGCTCCCCAGCCCAGGGTTCCCCCA
GCCCTGTGGAAGGGACTAGGAGCACTGTAGTAAATGGCAATTCTTTGACCTCAACCTGTGATGAGGGGAGGAAACTCACCTGCTGGCCCC
TCACCTGGGCACCTGGGGAGTGGGACAGAGTCTGGGTGTATTTATTTTCCTCCCCAGCAGGTGGGGAGGGGGTTTGGGGGCTTGCAAGTA
TGTTTTAGCATGTGTTTGGTTCTGGGGCCCCTTTTTACTCCCCTTGAGCTGAGATGGAACCCTTTTGGCCCCCGAGCTGGGGGCCATGAG
CTCCAGACCCCCAGCAACCCTCCTATCACCTCCCCTCCTTGCCTCCTGTGTAATCATTTCTTGGGCCCTCCTGAAACTTACACACAAAAC

>In-frame_ENST00000262435_ENST00000172229_TCGA-AR-A250-01A_SMURF2_chr17_62657947_-_NGFR_chr17_47579425_length(amino acids)=491AA_start in transcript=1697_stop in transcript=222
MGRQQGHFSLWTGSVVRSEGATRAALTGLWFWGLDSEVLPRGAQFCQAGPPQRVGVRAPQGLAGASVVGMWGGAGAPRLGSHRGCGSGLT
AQTLHEVGSLDAAQGGQEGVQCGAVLGGPACKQGANGAGLMGKGVYVLGLVAQLARQVPPGVPRRAVEKLLHLLPLGWGQAAVEASVTLE
GLARGCLRVGLLVMQALAVHGDATVAVEFFSLWWGRLVHWPAVGSLLVLLAAVPPLEGYVGHKAHNHSSQDGAIDRDEVVGGASGHHGLG
AAHHCGHHTCHRAGYEVLFWRCLRLLGAGGCAVRALWGCGPCNPTARDLLALGVGPACALAELALGVLAHGAGQARVHVVGLVGIRAVGA
LLAHGVLLVLAGEHEARARLAHAARLAAPSRLILVVAVGAAAHGVVGLHARRRHALEPHALGARLARLGRAHHVGERHAVQAGLTHGLVG

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000172229_TCGA-AR-A250_SMURF2_chr17_62657946_-_NGFR_chr17_47579424_length(transcript)=3466nt_BP=240nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGGTGTCCCTTGGAGGTGCCAAGGAGGCATGC
CCCACAGGCCTGTACACACACAGCGGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAACCAGACC
GTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACCGAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTC
CAGAGCATGTCGGCGCCGTGCGTGGAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGGCGCTGC
GAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGACAAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGC
ACGTATTCCGACGAGGCCAACCACGTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGCACACGC
TGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACACCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACC
CAGGAGCCTGAGGCACCTCCAGAACAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAGCCCGTG
GTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCTGCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTC
AAGAGGTGGAACAGCTGCAAGCAGAACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAACTCCAC
AGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCACACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGAC
GGAGGCCTCTACAGCAGCCTGCCCCCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGGCACCTG
GCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCCTGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACC
CAGGACAGCGCCACACTGGACGCCCTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAGTCCACT
GCCACATCCCCGGTGTGAGCCCAACCGGGGAGCCCCCGCCCCGCCCCACATTCCGACAACCGATGCTCCAGCCAACCCCTGTGGAGCCCG
CACCCCCACCCTTTGGGGGGGGCCCGCCTGGCAGAACTGAGCTCCTCTGGGCAGGACCTCAGAGTCCAGGCCCCAAAACCACAGCCCTGT
CAGTGCAGCCCGTGTGGCCCCTTCACTTCTGACCACACTTCCTGTCCAGAGAGAGAAGTGCCCCTGCTGCCTCCCCAACCCTGCCCCTGC
CCCGTCACCATCTCAGGCCACCTGCCCCCTTCTCCCACACTGCTAGGTGGGCCAGCCCCTCCCACCACAGCAGGTGTCATATATGGGGGG
CCAACACCAGGGATGGTACTAGGGGGAAGTGACAAGGCCCCAGAGACTCAGAGGGAGGAATCGAGGAACCAGAGCCATGGACTCTACACT
GTGAACTTGGGGAACAAGGGTGGCATCCCAGTGGCCTCAACCCTCCCTCAGCCCCTCTTGCCCCCCACCCCAGCCTAAGATGAAGAGGAT
CGGAGGCTTGTCAGAGCTGGGAGGGGTTTTCGAAGCTCAGCCCACCCCCCTCATTTTGGATATAGGTCAGTGAGGCCCAGGGAGAGGCCA
TGATTCGCCCAAAGCCAGACAGCAACGGGGAGGCCAAGTGCAGGCTGGCACCGCCTTCTCTAAATGAGGGGCCTCAGGTTTGCCTGAGGG
CGAGGGGAGGGTGGCAGGTGACCTTCTGGGAAATGGCTTGAAGCCAAGTCAGCTTTGCCTTCCACGCTGTCTCCAGACCCCCACCCCTTC
CCCACTGCCTGCCCACCCGTGGAGATGGGATGCTTGCCTAGGGCCTGGTCCATGATGGAGTCAGGTTTGGGGTTCGTGGAAAGGGTGCTG
CTTCCCTCTGCCTGTCCCTCTCAGGCATGCCTGTGTGACATCAGTGGCATGGCTCCAGTCTGCTGCCCTCCATCCCGACATGGACCCGGA
GCTAACACTGGCCCCTAGAATCAGCCTAGGGGTCAGGGACCAAGGACCCCTCACCTTGCAACACACAGACACACGCACACACACACACAG
GAGGAGAAATCTCACTTTTCTCCATGAGTTTTTTCTCTTGGGCTGAGACTGGATACTGCCCGGGGCAGCTGCCAGAGAAGCATCGGAGGG
AATTGAGGTCTGCTCGGCCGTCTTCACTCGCCCCCGGGTTTGGCGGGCCAAGGACTGCCGACCGAGGCTGGAGCTGGCGTCTGTCTTCAA
GGGCTTACACGTGGAGGAATGCTCCCCCATCCTCCCCTTCCCTGCAAACATGGGGTTGGCTGGGCCCAGAAGGTTGTGATGAAGAAAAGT
GGGCCAGTGTGGGAATGCGGCAAGAAGGAATTGACTTCGACTGTGACCTGTGGGGATTTCTCCCAGCTCTAGACAACCCTGCAAAGGACT
GTTTTTTCCTGAGCTTGGCCAGAAGGGGGCCATGAGGCCTCAGTGGACTTTCCACCCCCTCCCTGGCCTGTTCTGTTTTGCCTGAAGTTG
GAGTGAGTGTGGCTCCCCTCTATTTAGCATGACAAGCCCCAGGCAGGCTGTGCGCTGACAACCACCGCTCCCCAGCCCAGGGTTCCCCCA
GCCCTGTGGAAGGGACTAGGAGCACTGTAGTAAATGGCAATTCTTTGACCTCAACCTGTGATGAGGGGAGGAAACTCACCTGCTGGCCCC
TCACCTGGGCACCTGGGGAGTGGGACAGAGTCTGGGTGTATTTATTTTCCTCCCCAGCAGGTGGGGAGGGGGTTTGGGGGCTTGCAAGTA
TGTTTTAGCATGTGTTTGGTTCTGGGGCCCCTTTTTACTCCCCTTGAGCTGAGATGGAACCCTTTTGGCCCCCGAGCTGGGGGCCATGAG
CTCCAGACCCCCAGCAACCCTCCTATCACCTCCCCTCCTTGCCTCCTGTGTAATCATTTCTTGGGCCCTCCTGAAACTTACACACAAAAC

>In-frame_ENST00000262435_ENST00000172229_TCGA-AR-A250_SMURF2_chr17_62657946_-_NGFR_chr17_47579424_length(amino acids)=491AA_start in transcript=1697_stop in transcript=222
MGRQQGHFSLWTGSVVRSEGATRAALTGLWFWGLDSEVLPRGAQFCQAGPPQRVGVRAPQGLAGASVVGMWGGAGAPRLGSHRGCGSGLT
AQTLHEVGSLDAAQGGQEGVQCGAVLGGPACKQGANGAGLMGKGVYVLGLVAQLARQVPPGVPRRAVEKLLHLLPLGWGQAAVEASVTLE
GLARGCLRVGLLVMQALAVHGDATVAVEFFSLWWGRLVHWPAVGSLLVLLAAVPPLEGYVGHKAHNHSSQDGAIDRDEVVGGASGHHGLG
AAHHCGHHTCHRAGYEVLFWRCLRLLGAGGCAVRALWGCGPCNPTARDLLALGVGPACALAELALGVLAHGAGQARVHVVGLVGIRAVGA
LLAHGVLLVLAGEHEARARLAHAARLAAPSRLILVVAVGAAAHGVVGLHARRRHALEPHALGARLARLGRAHHVGERHAVQAGLTHGLVG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SMURF2-NGFR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SMURF2-NGFR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SMURF2-NGFR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNGFRC0011581Depressive disorder2PSYGENET
TgeneNGFRC0033578Prostatic Neoplasms2CTD_human
TgeneNGFRC0376358Malignant neoplasm of prostate2CTD_human
TgeneNGFRC0011570Mental Depression1PSYGENET
TgeneNGFRC0022333Jacksonian Seizure1CTD_human
TgeneNGFRC0027746Nerve Degeneration1CTD_human
TgeneNGFRC0036341Schizophrenia1PSYGENET
TgeneNGFRC0036572Seizures1CTD_human
TgeneNGFRC0149958Complex partial seizures1CTD_human
TgeneNGFRC0234533Generalized seizures1CTD_human
TgeneNGFRC0234535Clonic Seizures1CTD_human
TgeneNGFRC0270715Degenerative Diseases, Central Nervous System1CTD_human
TgeneNGFRC0270824Visual seizure1CTD_human
TgeneNGFRC0270844Tonic Seizures1CTD_human
TgeneNGFRC0270846Epileptic drop attack1CTD_human
TgeneNGFRC0422850Seizures, Somatosensory1CTD_human
TgeneNGFRC0422852Seizures, Auditory1CTD_human
TgeneNGFRC0422853Olfactory seizure1CTD_human
TgeneNGFRC0422854Gustatory seizure1CTD_human
TgeneNGFRC0422855Vertiginous seizure1CTD_human
TgeneNGFRC0494475Tonic - clonic seizures1CTD_human
TgeneNGFRC0524851Neurodegenerative Disorders1CTD_human
TgeneNGFRC0751056Non-epileptic convulsion1CTD_human
TgeneNGFRC0751110Single Seizure1CTD_human
TgeneNGFRC0751123Atonic Absence Seizures1CTD_human
TgeneNGFRC0751494Convulsive Seizures1CTD_human
TgeneNGFRC0751495Seizures, Focal1CTD_human
TgeneNGFRC0751496Seizures, Sensory1CTD_human
TgeneNGFRC0751733Degenerative Diseases, Spinal Cord1CTD_human
TgeneNGFRC3495874Nonepileptic Seizures1CTD_human
TgeneNGFRC4048158Convulsions1CTD_human
TgeneNGFRC4316903Absence Seizures1CTD_human
TgeneNGFRC4317109Epileptic Seizures1CTD_human
TgeneNGFRC4317123Myoclonic Seizures1CTD_human
TgeneNGFRC4505436Generalized Absence Seizures1CTD_human