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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SMURF2-NUDT3 (FusionGDB2 ID:83755)

Fusion Gene Summary for SMURF2-NUDT3

Fusion gene summary

Fusion gene information	Fusion gene name: SMURF2-NUDT3
	Fusion gene ID: 83755
		Hgene	Tgene
	Gene symbol	SMURF2	NUDT3
	Gene ID	64750	11165
	Gene name	SMAD specific E3 ubiquitin protein ligase 2	nudix hydrolase 3
	Synonyms	-	DIPP\|DIPP-1\|DIPP1
	Cytomap	17q23.3-q24.1	6p21.31
	Type of gene	protein-coding	protein-coding
	Description	E3 ubiquitin-protein ligase SMURF2E3 ubiquitin ligase SMURF2HECT-type E3 ubiquitin transferase SMURF2SMAD ubiquitination regulatory factor 2hSMURF2	diphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262435, ENST00000578200,	ENST00000607016,
Fusion gene scores	* DoF score	18 X 11 X 13=2574	13 X 7 X 8=728
	# samples	24	15
	** MAII score	log2(24/2574*10)=-3.42290574261218 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/728*10)=-2.27897594970282 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SMURF2 [Title/Abstract] AND NUDT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SMURF2(62657946)-NUDT3(34263462), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SMURF2	GO:0006511	ubiquitin-dependent protein catabolic process	14755250
Hgene	SMURF2	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	19255252
Hgene	SMURF2	GO:0030579	ubiquitin-dependent SMAD protein catabolic process	19122240
Hgene	SMURF2	GO:1901165	positive regulation of trophoblast cell migration	19255252
Tgene	NUDT3	GO:0071544	diphosphoinositol polyphosphate catabolic process	10585413

Fusion gene breakpoints across SMURF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUDT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A2J1	SMURF2	chr17	62657946	-	NUDT3	chr6	34263462	-

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Fusion Gene ORF analysis for SMURF2-NUDT3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000262435	ENST00000607016	SMURF2	chr17	62657946	-	NUDT3	chr6	34263462	-
intron-3CDS	ENST00000578200	ENST00000607016	SMURF2	chr17	62657946	-	NUDT3	chr6	34263462	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000262435

SMURF2

chr17

62657946

ENST00000607016

NUDT3

chr6

34263462

9623

240

3751

3347

134

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262435	ENST00000607016	SMURF2	chr17	62657946	-	NUDT3	chr6	34263462	-	0.7034966	0.29650342

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Fusion Genomic Features for SMURF2-NUDT3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMURF2-NUDT3

Go to
FGviewer for the breakpoints of chr17:62657946-chr6:34263462
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NUDT3

chr17:62657946

chr6:34263462

ENST00000607016

89_91

70.0

173.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SMURF2

chr17:62657946

chr6:34263462

ENST00000262435

157_190

17.333333333333332

749.0

Domain

WW 1

Hgene

SMURF2

chr17:62657946

chr6:34263462

ENST00000262435

1_119

17.333333333333332

749.0

Domain

Hgene

SMURF2

chr17:62657946

chr6:34263462

ENST00000262435

414_748

17.333333333333332

749.0

Domain

HECT

Tgene

NUDT3

chr17:62657946

chr6:34263462

ENST00000607016

17_142

70.0

173.0

Domain

Nudix hydrolase

Tgene

NUDT3

chr17:62657946

chr6:34263462

ENST00000607016

51_72

70.0

173.0

Motif

Note=Nudix box

Tgene

NUDT3

chr17:62657946

chr6:34263462

ENST00000607016

18_20

70.0

173.0

Region

Substrate binding

Tgene

NUDT3

chr17:62657946

chr6:34263462

ENST00000607016

39_41

70.0

173.0

Region

Substrate binding

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Fusion Gene Sequence for SMURF2-NUDT3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000262435_ENST00000607016_TCGA-DX-A2J1_SMURF2_chr17_62657946_-_NUDT3_chr6_34263462_length(transcript)=9623nt_BP=240nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGGCTGGAGTAAAAGGGACATTGGGAAGATTA
GTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGATTCA
GTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTT
GAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCAGGC
ATCAGATGACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTCCAC
TTCTCACAGGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGATGGG
GCTTTTTCTTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCACCC
CTGCAGTCCTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGACGT
TTTCTTTGATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTACAG
TTCAGTAGAGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAGAAA
GAGAAATTTGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTTTGT
TTTCGATGCTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCTTCA
TAGTGCTCCCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTTTTA
TTTTTTTTTAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGACAG
TAGAGTTGGAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTCCGT
AATGCTATTTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGAAGC
ATCCAACTTTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCACCT
GCTTGCTTGTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACCAGG
ATATGAAAGGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTTTGA
TACAGTTTCGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTACACT
GACTGATCCGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCGCCT
CATTTAAAAATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCCTGT
GTCATTTAGTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCTGTA
ATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCT
ACTAAAAATGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAGAGG
TTGCAGTGAGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTTTTT
TTTTTTTTTGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACCATG
ATACCTCTGGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTTACT
ATTCACACATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCAAAA
TAAAGTAGATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGTACT
TTGCAGGAAAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCA
AGGCAGGTGGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAGCTG
GGCATGATGGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTAAGC
CAAGATCATGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGTGCT
AACAGTAATTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGATTG
TTGTTGGTGTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACTGAG
AGATTGTGCTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACTGGG
ATTCTGATGATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGATAGA
TTAGTTAGACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATATTTC
ACTGACATTGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCTAGC
CTCTCGCTCACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAGATA
GCAGTGGATTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATTTTC
TCTCTGTCTTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTCCAG
AAACAGTGCAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAGTGT
CCACCACTCCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAGTAT
CACCCCCTCTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAACAT
GAGGCACTTGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAATGT
GTTGCTACATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGCTTG
CTTAGAAGAAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCTACA
TACAGTGCTCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGTTAT
CCTTCACATATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAAAAC
AGCTTAGCCTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTTTAA
TATTCTCTAATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATGAGA
GTTGGCTGTCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGGACA
CTTGTGGGACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCTTAA
AGACTGTGGAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGTTGG
ATAGAGCCTATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCACCTG
CCTAACTTGGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAGGAG
CTGTGTTTCTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATTGGC
TGCAGTCCCTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATACTCT
CCTTTGGAGGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAACTCT
TGTCTTTAGCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAAATA
GTTTGTCCTTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAG
GCGGGTGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGT
GTAGTGGCACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGCCGA
GATCCCGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCCCAT
TTTGTGATGATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGGTTA
TGTCTCTTCCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGGGGA
GGGGAGCTTATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTGGAA
AGAAGTCATTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTATTTG
ACTTCCTATCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGTTTT
GCCAGGTTCATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAAGAT
TCTATTAATCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGAGAA
CATCTCAACAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTGAGG
AAAAAAAGCAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGGAAA
ATCATTTTGCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAATTGA
AAATGGTAAGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAACCTT
TGTCTTTAACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCAGCA
TAACAGATATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCACGTA
GAACCTCCCCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAGCAA
GAGGCTTGTGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTCGTG
ACTGGGAGCATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAGAAT
CTCACTCTTTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGTGTT
GCATTAGTAGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCTATT
GTTTTGTGATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATATAG
CTTACCAGTTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTCTCA
CCTTCTTAGGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAAGAC
TTTGTCTTCCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTGTGT
AGTCTCCAAACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACATCCC
TGGGACCATTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGCCAA
GTTCAACAAATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTATTT
CTTGTCCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGCCAG
GGACCCATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTGTTC
ATTTCCATCAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCATAT
ATAGATCTCCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAGGAT
GGCAAGGATGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTAAAC
CTCTTGGCACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGAGCT
ACCCAACCTGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAAGTT
CAAGCTTTTCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGGAGC
TGAGGGGAGTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCTTCA
CACCTCCTTCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTTTGG
TCTGAGACAGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACTAAT
GTATCCCTTATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTTGAC
CACCCCCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTTCCA

>In-frame_ENST00000262435_ENST00000607016_TCGA-DX-A2J1_SMURF2_chr17_62657946_-_NUDT3_chr6_34263462_length(amino acids)=134AA_start in transcript=3751_stop in transcript=3347
MFLSSLNEVSSGRINDKSMSVKYSANRVAFVLSFDYFLWGDKGIATMGLTNLSLKDCDDILNKDSHGVYCAKEGKSQIIRIPVQQKTAPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMURF2-NUDT3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SMURF2-NUDT3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SMURF2-NUDT3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source