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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMURF2-PUM2 (FusionGDB2 ID:83758)

Fusion Gene Summary for SMURF2-PUM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SMURF2-PUM2
Fusion gene ID: 83758
HgeneTgene
Gene symbol

SMURF2

PUM2

Gene ID

64750

23369

Gene nameSMAD specific E3 ubiquitin protein ligase 2pumilio RNA binding family member 2
Synonyms-PUMH2|PUML2
Cytomap

17q23.3-q24.1

2p24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SMURF2E3 ubiquitin ligase SMURF2HECT-type E3 ubiquitin transferase SMURF2SMAD ubiquitination regulatory factor 2hSMURF2pumilio homolog 2pumilio-2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262435, ENST00000578200, 
ENST00000338086, ENST00000319801, 
ENST00000361078, ENST00000536417, 
ENST00000403432, ENST00000420234, 
Fusion gene scores* DoF score18 X 11 X 13=257411 X 9 X 5=495
# samples 2413
** MAII scorelog2(24/2574*10)=-3.42290574261218
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/495*10)=-1.92891690193852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMURF2 [Title/Abstract] AND PUM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMURF2(62574609)-PUM2(20460227), # samples:1
SMURF2(62574610)-PUM2(20460227), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMURF2

GO:0006511

ubiquitin-dependent protein catabolic process

14755250

HgeneSMURF2

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

19255252

HgeneSMURF2

GO:0030579

ubiquitin-dependent SMAD protein catabolic process

19122240

HgeneSMURF2

GO:1901165

positive regulation of trophoblast cell migration

19255252

TgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

TgenePUM2

GO:0043488

regulation of mRNA stability

26724866

TgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

TgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845


check buttonFusion gene breakpoints across SMURF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PUM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HDSMURF2chr17

62574609

-PUM2chr2

20460227

-
ChimerDB4STADTCGA-HU-A4HD-01ASMURF2chr17

62574610

-PUM2chr2

20460227

-


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Fusion Gene ORF analysis for SMURF2-PUM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262435ENST00000338086SMURF2chr17

62574609

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000319801SMURF2chr17

62574609

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000361078SMURF2chr17

62574609

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000536417SMURF2chr17

62574609

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000403432SMURF2chr17

62574609

-PUM2chr2

20460227

-
5CDS-intronENST00000262435ENST00000420234SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000338086SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000319801SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000361078SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000536417SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000403432SMURF2chr17

62574609

-PUM2chr2

20460227

-
intron-intronENST00000578200ENST00000420234SMURF2chr17

62574609

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000338086SMURF2chr17

62574610

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000319801SMURF2chr17

62574610

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000361078SMURF2chr17

62574610

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000536417SMURF2chr17

62574610

-PUM2chr2

20460227

-
In-frameENST00000262435ENST00000403432SMURF2chr17

62574610

-PUM2chr2

20460227

-
5CDS-intronENST00000262435ENST00000420234SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000338086SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000319801SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000361078SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000536417SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-3CDSENST00000578200ENST00000403432SMURF2chr17

62574610

-PUM2chr2

20460227

-
intron-intronENST00000578200ENST00000420234SMURF2chr17

62574610

-PUM2chr2

20460227

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262435SMURF2chr1762574609-ENST00000338086PUM2chr220460227-490910451882014608
ENST00000262435SMURF2chr1762574609-ENST00000319801PUM2chr220460227-491410451882020610
ENST00000262435SMURF2chr1762574609-ENST00000361078PUM2chr220460227-491410451882020610
ENST00000262435SMURF2chr1762574609-ENST00000536417PUM2chr220460227-229010451882014608
ENST00000262435SMURF2chr1762574609-ENST00000403432PUM2chr220460227-229010451882014608
ENST00000262435SMURF2chr1762574610-ENST00000338086PUM2chr220460227-490910451882014608
ENST00000262435SMURF2chr1762574610-ENST00000319801PUM2chr220460227-491410451882020610
ENST00000262435SMURF2chr1762574610-ENST00000361078PUM2chr220460227-491410451882020610
ENST00000262435SMURF2chr1762574610-ENST00000536417PUM2chr220460227-229010451882014608
ENST00000262435SMURF2chr1762574610-ENST00000403432PUM2chr220460227-229010451882014608

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262435ENST00000338086SMURF2chr1762574609-PUM2chr220460227-0.0001067010.9998933
ENST00000262435ENST00000319801SMURF2chr1762574609-PUM2chr220460227-9.99E-050.9999001
ENST00000262435ENST00000361078SMURF2chr1762574609-PUM2chr220460227-9.99E-050.9999001
ENST00000262435ENST00000536417SMURF2chr1762574609-PUM2chr220460227-0.0017270330.998273
ENST00000262435ENST00000403432SMURF2chr1762574609-PUM2chr220460227-0.0017270330.998273
ENST00000262435ENST00000338086SMURF2chr1762574610-PUM2chr220460227-0.0001067010.9998933
ENST00000262435ENST00000319801SMURF2chr1762574610-PUM2chr220460227-9.99E-050.9999001
ENST00000262435ENST00000361078SMURF2chr1762574610-PUM2chr220460227-9.99E-050.9999001
ENST00000262435ENST00000536417SMURF2chr1762574610-PUM2chr220460227-0.0017270330.998273
ENST00000262435ENST00000403432SMURF2chr1762574610-PUM2chr220460227-0.0017270330.998273

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Fusion Genomic Features for SMURF2-PUM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMURF2-PUM2


check button Go to

FGviewer for the breakpoints of chr17:62574609-chr2:20460227

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMURF2chr17:62574609chr2:20460227ENST00000262435-919157_190285.6666666666667749.0DomainWW 1
HgeneSMURF2chr17:62574609chr2:20460227ENST00000262435-9191_119285.6666666666667749.0DomainC2
HgeneSMURF2chr17:62574610chr2:20460227ENST00000262435-919157_190285.6666666666667749.0DomainWW 1
HgeneSMURF2chr17:62574610chr2:20460227ENST00000262435-9191_119285.6666666666667749.0DomainC2
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119706_1048662.6666666666666988.0DomainPUM-HD
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119706_1048662.6666666666666988.0DomainPUM-HD
TgenePUM2chr17:62574609chr2:20460227ENST0000031980111191002_1006662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119741_745662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119777_781662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119813_817662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119851_855662.6666666666666988.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119887_891662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119923_927662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119959_963662.6666666666666988.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST0000033808612201002_1006741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220741_745741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220777_781741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220813_817741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220851_855741.66666666666661065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220887_891741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220923_927741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220959_963741.66666666666661065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST0000036107812201002_1006741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220741_745741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220777_781741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220813_817741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220851_855741.66666666666661067.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220887_891741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220923_927741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220959_963741.66666666666661067.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST0000040343213211002_1006741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321741_745741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321777_781741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321813_817741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321851_855741.66666666666661065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321887_891741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321923_927741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321959_963741.66666666666661065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST0000031980111191002_1006662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119741_745662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119777_781662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119813_817662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119851_855662.6666666666666988.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119887_891662.6666666666666988.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119923_927662.6666666666666988.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119959_963662.6666666666666988.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST0000033808612201002_1006741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220741_745741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220777_781741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220813_817741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220851_855741.66666666666661065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220887_891741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220923_927741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220959_963741.66666666666661065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST0000036107812201002_1006741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220741_745741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220777_781741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220813_817741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220851_855741.66666666666661067.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220887_891741.66666666666661067.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220923_927741.66666666666661067.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220959_963741.66666666666661067.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST0000040343213211002_1006741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321741_745741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321777_781741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321813_817741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321851_855741.66666666666661065.0RegionNon-specific-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321887_891741.66666666666661065.0RegionAdenine-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321923_927741.66666666666661065.0RegionUracil-nucleotide binding in RNA target
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321959_963741.66666666666661065.0RegionGuanine-nucleotide binding in RNA target
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119726_761662.6666666666666988.0RepeatPumilio 1
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119762_797662.6666666666666988.0RepeatPumilio 2
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119798_835662.6666666666666988.0RepeatPumilio 3
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119836_871662.6666666666666988.0RepeatPumilio 4
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119872_907662.6666666666666988.0RepeatPumilio 5
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119908_943662.6666666666666988.0RepeatPumilio 6
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119944_979662.6666666666666988.0RepeatPumilio 7
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119983_1022662.6666666666666988.0RepeatPumilio 8
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220762_797741.66666666666661065.0RepeatPumilio 2
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220798_835741.66666666666661065.0RepeatPumilio 3
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220836_871741.66666666666661065.0RepeatPumilio 4
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220872_907741.66666666666661065.0RepeatPumilio 5
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220908_943741.66666666666661065.0RepeatPumilio 6
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220944_979741.66666666666661065.0RepeatPumilio 7
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220983_1022741.66666666666661065.0RepeatPumilio 8
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220762_797741.66666666666661067.0RepeatPumilio 2
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220798_835741.66666666666661067.0RepeatPumilio 3
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220836_871741.66666666666661067.0RepeatPumilio 4
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220872_907741.66666666666661067.0RepeatPumilio 5
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220908_943741.66666666666661067.0RepeatPumilio 6
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220944_979741.66666666666661067.0RepeatPumilio 7
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220983_1022741.66666666666661067.0RepeatPumilio 8
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321762_797741.66666666666661065.0RepeatPumilio 2
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321798_835741.66666666666661065.0RepeatPumilio 3
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321836_871741.66666666666661065.0RepeatPumilio 4
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321872_907741.66666666666661065.0RepeatPumilio 5
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321908_943741.66666666666661065.0RepeatPumilio 6
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321944_979741.66666666666661065.0RepeatPumilio 7
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321983_1022741.66666666666661065.0RepeatPumilio 8
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119726_761662.6666666666666988.0RepeatPumilio 1
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119762_797662.6666666666666988.0RepeatPumilio 2
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119798_835662.6666666666666988.0RepeatPumilio 3
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119836_871662.6666666666666988.0RepeatPumilio 4
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119872_907662.6666666666666988.0RepeatPumilio 5
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119908_943662.6666666666666988.0RepeatPumilio 6
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119944_979662.6666666666666988.0RepeatPumilio 7
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119983_1022662.6666666666666988.0RepeatPumilio 8
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220762_797741.66666666666661065.0RepeatPumilio 2
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220798_835741.66666666666661065.0RepeatPumilio 3
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220836_871741.66666666666661065.0RepeatPumilio 4
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220872_907741.66666666666661065.0RepeatPumilio 5
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220908_943741.66666666666661065.0RepeatPumilio 6
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220944_979741.66666666666661065.0RepeatPumilio 7
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220983_1022741.66666666666661065.0RepeatPumilio 8
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220762_797741.66666666666661067.0RepeatPumilio 2
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220798_835741.66666666666661067.0RepeatPumilio 3
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220836_871741.66666666666661067.0RepeatPumilio 4
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220872_907741.66666666666661067.0RepeatPumilio 5
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220908_943741.66666666666661067.0RepeatPumilio 6
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220944_979741.66666666666661067.0RepeatPumilio 7
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220983_1022741.66666666666661067.0RepeatPumilio 8
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321762_797741.66666666666661065.0RepeatPumilio 2
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321798_835741.66666666666661065.0RepeatPumilio 3
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321836_871741.66666666666661065.0RepeatPumilio 4
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321872_907741.66666666666661065.0RepeatPumilio 5
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321908_943741.66666666666661065.0RepeatPumilio 6
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321944_979741.66666666666661065.0RepeatPumilio 7
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321983_1022741.66666666666661065.0RepeatPumilio 8

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMURF2chr17:62574609chr2:20460227ENST00000262435-919414_748285.6666666666667749.0DomainHECT
HgeneSMURF2chr17:62574610chr2:20460227ENST00000262435-919414_748285.6666666666667749.0DomainHECT
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119278_488662.6666666666666988.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119359_405662.6666666666666988.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003198011119520_687662.6666666666666988.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220278_488741.66666666666661065.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220359_405741.66666666666661065.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220520_687741.66666666666661065.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220278_488741.66666666666661067.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220359_405741.66666666666661067.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220520_687741.66666666666661067.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321278_488741.66666666666661065.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321359_405741.66666666666661065.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321520_687741.66666666666661065.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119278_488662.6666666666666988.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119359_405662.6666666666666988.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003198011119520_687662.6666666666666988.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220278_488741.66666666666661065.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220359_405741.66666666666661065.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220520_687741.66666666666661065.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220278_488741.66666666666661067.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220359_405741.66666666666661067.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220520_687741.66666666666661067.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321278_488741.66666666666661065.0Compositional biasNote=Ala-rich
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321359_405741.66666666666661065.0Compositional biasNote=Gln-rich
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321520_687741.66666666666661065.0Compositional biasNote=Ser-rich
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220706_1048741.66666666666661065.0DomainPUM-HD
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220706_1048741.66666666666661067.0DomainPUM-HD
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321706_1048741.66666666666661065.0DomainPUM-HD
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220706_1048741.66666666666661065.0DomainPUM-HD
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220706_1048741.66666666666661067.0DomainPUM-HD
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321706_1048741.66666666666661065.0DomainPUM-HD
TgenePUM2chr17:62574609chr2:20460227ENST000003380861220726_761741.66666666666661065.0RepeatPumilio 1
TgenePUM2chr17:62574609chr2:20460227ENST000003610781220726_761741.66666666666661067.0RepeatPumilio 1
TgenePUM2chr17:62574609chr2:20460227ENST000004034321321726_761741.66666666666661065.0RepeatPumilio 1
TgenePUM2chr17:62574610chr2:20460227ENST000003380861220726_761741.66666666666661065.0RepeatPumilio 1
TgenePUM2chr17:62574610chr2:20460227ENST000003610781220726_761741.66666666666661067.0RepeatPumilio 1
TgenePUM2chr17:62574610chr2:20460227ENST000004034321321726_761741.66666666666661065.0RepeatPumilio 1


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Fusion Gene Sequence for SMURF2-PUM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262435_ENST00000338086_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(transcript)=4909nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC
TGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTAAAGTCA
CAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACAACAGGT
TTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATAAATATT
ATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAGTGGTTT
GAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGAAATATT
GTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGTTAAGTC
ACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTGAGGAAG
TGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTGATAGCT
CAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAAGTTTAC
ACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGTACATTT
GTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTCTTTGAC
CTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTTCAGAAG
TATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAATTTGGAT
CACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTTTCATCT
TATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGTATGATA
ACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTTTTAAGG
CAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTATATTCA
GTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCAGTGCTG
AAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCTTCTGAG
CACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAGGCATAC
TTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCGTTCCTT
CTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAAAGCCGC
TGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCAGGATCA
AAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTTGGCACA
GGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACTCATTCC
CATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTACAGTCTG
CCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAATAAAACA
ATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGCTCTTAT
TGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTATGAAAT

>In-frame_ENST00000262435_ENST00000338086_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000319801_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(transcript)=4914nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAAT
GTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCA
AGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTAC
CTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTC
GACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAA
AGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACA
CCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGA
TTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGG
ACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTT
TTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATT
TGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTG
GATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTA
AAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACA
ACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATA
AATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAG
TGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGA
AATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGT
TAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTG
AGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTG
ATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAA
GTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGT
ACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTC
TTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTT
CAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAAT
TTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTT
TCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGT
ATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTT
TTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTA
TATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCA
GTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCT
TCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAG
GCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCG
TTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAA
AGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCA
GGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTT
GGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACT
CATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTAC
AGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAAT
AAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGC
TCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTA

>In-frame_ENST00000262435_ENST00000319801_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(amino acids)=610AA_start in transcript=188_stop in transcript=2020
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPIL
EELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMM

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000361078_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(transcript)=4914nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAAT
GTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCA
AGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTAC
CTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTC
GACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAA
AGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACA
CCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGA
TTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGG
ACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTT
TTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATT
TGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTG
GATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTA
AAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACA
ACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATA
AATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAG
TGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGA
AATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGT
TAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTG
AGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTG
ATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAA
GTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGT
ACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTC
TTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTT
CAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAAT
TTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTT
TCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGT
ATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTT
TTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTA
TATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCA
GTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCT
TCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAG
GCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCG
TTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAA
AGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCA
GGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTT
GGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACT
CATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTAC
AGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAAT
AAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGC
TCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTA

>In-frame_ENST00000262435_ENST00000361078_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(amino acids)=610AA_start in transcript=188_stop in transcript=2020
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPIL
EELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMM

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000536417_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(transcript)=2290nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC

>In-frame_ENST00000262435_ENST00000536417_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000403432_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(transcript)=2290nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC

>In-frame_ENST00000262435_ENST00000403432_TCGA-HU-A4HD_SMURF2_chr17_62574609_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000338086_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(transcript)=4909nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC
TGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTAAAGTCA
CAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACAACAGGT
TTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATAAATATT
ATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAGTGGTTT
GAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGAAATATT
GTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGTTAAGTC
ACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTGAGGAAG
TGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTGATAGCT
CAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAAGTTTAC
ACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGTACATTT
GTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTCTTTGAC
CTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTTCAGAAG
TATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAATTTGGAT
CACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTTTCATCT
TATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGTATGATA
ACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTTTTAAGG
CAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTATATTCA
GTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCAGTGCTG
AAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCTTCTGAG
CACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAGGCATAC
TTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCGTTCCTT
CTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAAAGCCGC
TGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCAGGATCA
AAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTTGGCACA
GGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACTCATTCC
CATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTACAGTCTG
CCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAATAAAACA
ATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGCTCTTAT
TGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTATGAAAT

>In-frame_ENST00000262435_ENST00000338086_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000319801_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(transcript)=4914nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAAT
GTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCA
AGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTAC
CTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTC
GACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAA
AGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACA
CCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGA
TTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGG
ACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTT
TTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATT
TGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTG
GATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTA
AAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACA
ACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATA
AATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAG
TGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGA
AATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGT
TAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTG
AGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTG
ATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAA
GTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGT
ACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTC
TTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTT
CAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAAT
TTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTT
TCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGT
ATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTT
TTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTA
TATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCA
GTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCT
TCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAG
GCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCG
TTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAA
AGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCA
GGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTT
GGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACT
CATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTAC
AGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAAT
AAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGC
TCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTA

>In-frame_ENST00000262435_ENST00000319801_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(amino acids)=610AA_start in transcript=188_stop in transcript=2020
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPIL
EELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMM

--------------------------------------------------------------
>In-frame_ENST00000262435_ENST00000361078_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(transcript)=4914nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGGTAATTAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAAT
GTGTGAAAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCA
AGGGACAAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTAC
CTATCTTAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTC
GACCTGAAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAA
AGTGTGTTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACA
CCATGATGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGA
TTCGACCTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGG
ACCTAGGACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTT
TTTTGTGTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATT
TGTAAATTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTG
GATTGCTGGCAAAGCACAGAATGCCTGTATATGATGTAACTGTATCAAAAATAAAAAGCTGTCACATATTTTGTAAATTTTTACCTTGTA
AAGTCACAAAAATAGTTTTTAAAGGAAAAAGTACAGTATTCTTTTAATAAACTGGCTCACAGTCTGGTAGGTCTACAACCCCATAGCACA
ACAGGTTTATAGAGATGTATATAGAATTATAGTCCTTATTTTTTTCCTTTGCGTGAAACCTTTTATAACAGATTAACAATCAACTGCATA
AATATTATTAATATTTTAAAAAGAGTTAAGTTGTATTTTGATAATTCACAAACTATCATGCAAATAACGAGTAAGTAGACAAGAATAAAG
TGGTTTGAGATGAAAAGAACCTAACATTATTTACAGTAGATGTGGTTTTAATACAATTACTGCCCTAAAATGTCTCTGGCAATGTACAGA
AATATTGTATATACTTACATATGTAATTGTTGTAAGAGTTAAATACAAAATCATGGTGACACTTCCAATTAAGTGCACTAAATGAAAAGT
TAAGTCACTTATTAACTTTTCAGTTTGGTTTGCAATGAGAAAGAGTGGAAATTTGTATTTTGTTTTGCTTATAGAATTACAGACATGTTG
AGGAAGTGTTGAGCTTTATTTTGCTTTTTCATAGAGGCAGAAAGTAGGAACCAGATAGAGATGAAAAGGGGCCACTGAAAAGTGAATTTG
ATAGCTCAGCATTTAAGCATGATTACATATTCAGATAGCTCTTTTTGCTTTCTATAAATATATGCATTGTGTGTGTAGTAATAGATGTAA
GTTTACACTTTGAAAGGAAATCTTGTTTCAATGTTTATTATAAAAGCCTTGCTAATTTAGTAGTGATGCTTTCCTTGGTTGTACAGGTGT
ACATTTGTAAACCTTCATGCTGTAAATGGAATTTGTTTTATCTCTTTGGGATACATTTGCATTTTAGTGTACATTTACGTCCCTGCCCTC
TTTGACCTGGCAATATAGTGTTGTATAATGTAAATTTATTTCTCCAAATCGAGAGTGATTTTTTAAAAATTTTTTATCTTTATATGGTTT
CAGAAGTATGAACCAGCTTTCTTTTTATTATTGTGAGATCATTTTGTTTTATAACATAGTTGTTGACTGTTAATATGGACCTGCTAGAAT
TTGGATCACTTTCAATTGAAGTCAGGGTATTGTGCATAATAGAAAGTATTGGACTGAGATATTTGGTTACCATGGAGGCCAATGCTTTTT
TCATCTTATTAAATGTGATGTGACTTTTTTCTTTGTACAGAAGAGTACTGTATTTTTGAATAGCCTACTCCCAAGTAAGAGCAAATCTGT
ATGATAACATTTTTTCCTCTGGACATAAGACATAACAGTAACACGATGTACATTTACAAGCGGCCTTATGTACATTTCCCAACAATCTTT
TTAAGGCAAAATTGTGACCATATGTGTATAATTAAAATCGTTTTTAATCCTTTGCCTATGAAAATATTTTGGAAAAAAACTTGCTGTGTA
TATTCAGTTTCTGAAAGATAAAGAAAGTGCTTTGTATTTTGTTGAAGTCAGTATTTTGTATAAACATTTATGTTGACCCACTTATGTTCA
GTGCTGAAAACTAAAATGAACATGCTATTCTGTCAGCTGAATATGGAAGAGATCTTTTTTTACTAGAGATCTGCAGAAGAAACGCAATCT
TCTGAGCACAATATGGAATCTAAAGGTTTTATCACTTAGTTGTTCATATTATGAACCTAAAAATAATGGCATAAAGTTTGGGGATGCCAG
GCATACTTTTTCATGTTTGGTGTTGAGTTATTTTACTTTTCTAACCCAACATTCCTTGGTGAGACCATTAAATCCAAACACTTGTCACCG
TTCCTTCTCATAGTCACTCTGGGTCATCAGCATGTCCCAGTCACTGCAGCAACGCCTTGTGTTTGTTTCATTTTTTTAAAACCCACACAA
AGCCGCTGTCTCACTTTTTCCTACTTTACCAACCTCAGAGTATTTCGGCCCGTATCGAACTTTTGTTCTCAGTATCAGCCCATGGTTTCA
GGATCAAAGCTGTCATGTTGGAGATTGGTAATGGCTTTCCTGTCTTTGTACAGTTGAATTCCTAGTCTTCCTTCATCCTTGCCCTCTGTT
GGCACAGGCATTATCTCTGCAATTTTAGAAAATGACAAGTAGAGAATACTACATTGAGAAACTAAACCCTCTTCTTGGGGTCCTGATACT
CATTCCCATTTGTCCCAGTGCTGACAACCCAATCTTCCCAATACTTTCAGGCCTGCTCTACAAAAGTACCTGTTCTTGTAGAAATTTTAC
AGTCTGCCATTTTGGGTGCCCACCCCAATTTTTACCTTTTAGTAAGTTGGCATGAAATTTTGGTAAAATCTGAAAATCACATTTCAGAAT
AAAACAATTGGGCAAAACTACCTAGGCTTTACTCTTGAGTGTCTCCTTTTGATAGGGATTGTTTCTGGACCAGTTTGTCTAAGTCCTGGC
TCTTATTGGTTCATATGAAATAATGTTAACTTCACTTCTTTGTATATTATGTATAAATTAGAAAATGAAAAATGTGTGAATAACATTGTA

>In-frame_ENST00000262435_ENST00000361078_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(amino acids)=610AA_start in transcript=188_stop in transcript=2020
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPIL
EELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMM

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>In-frame_ENST00000262435_ENST00000536417_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(transcript)=2290nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC

>In-frame_ENST00000262435_ENST00000536417_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

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>In-frame_ENST00000262435_ENST00000403432_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(transcript)=2290nt_BP=1045nt
GGGGAGCTCGGCGTCCCGCTCCCTCCGCGGCTCATGGCGACGACTCTCGGCACATCCGGGACCCTCCGGCCGTGGCGGCCGAGGCGCCGG
CTGCTCGGGCCCCAGCCCCGGCCGCTGTGGTGACTCCGCCGCGCCTCGCCGTCGCCCCCGTGCCGCCCGCCGCCCCCGCCGCCCCCGCCG
CCGGGGACATGTCTAACCCCGGAGGCCGGAGGAACGGGCCCGTCAAGCTGCGCCTGACAGTACTCTGTGCAAAAAACCTGGTGAAAAAGG
ATTTTTTCCGACTTCCTGATCCATTTGCTAAGGTGGTGGTTGATGGATCTGGGCAATGCCATTCTACAGATACTGTGAAGAATACGCTTG
ATCCAAAGTGGAATCAGCATTATGACCTGTATATTGGAAAGTCTGATTCAGTTACGATCAGTGTATGGAATCACAAGAAGATCCATAAGA
AACAAGGTGCTGGATTTCTCGGTTGTGTTCGTCTTCTTTCCAATGCCATCAACCGCCTCAAAGACACTGGTTATCAGAGGTTGGATTTAT
GCAAACTCGGGCCAAATGACAATGATACAGTTAGAGGACAGATAGTAGTAAGTCTTCAGTCCAGAGACCGAATAGGCACAGGAGGACAAG
TTGTGGACTGCAGTCGTTTATTTGATAACGATTTACCAGACGGCTGGGAAGAAAGGAGAACCGCCTCTGGAAGAATCCAGTATCTAAACC
ATATAACAAGAACTACGCAATGGGAGCGCCCAACACGACCGGCATCCGAATATTCTAGCCCTGGCAGACCTCTTAGCTGCTTTGTTGATG
AGAACACTCCAATTAGTGGAACAAATGGTGCAACATGTGGACAGTCTTCAGATCCCAGGCTGGCAGAGAGGAGAGTCAGGTCACAACGAC
ATAGAAATTACATGAGCAGAACACATTTACATACTCCTCCAGACCTACCAGAAGGCTATGAACAGAGGACAACGCAACAAGGCCAGGTGT
ATTTCTTACATACACAGACTGGTGTGAGCACATGGCATGATCCAAGAGTGCCCAGATTCATACAGCAAAAACTAGAGAGAGCTACTCCAG
CTGAGCGACAGATGGTATTTAATGAAATTCTGCAAGCAGCCTATCAATTAATGACTGATGTTTTTGGCAACTATGTTATACAGAAGTTTT
TTGAGTTTGGGAGTCTGGATCAAAAATTAGCCCTGGCTACTCGTATTCGTGGTCATGTTCTACCCTTAGCCTTGCAGATGTATGGCTGCC
GCGTTATTCAGAAAGCATTAGAATCTATTTCTTCTGACCAGCAGAGTGAAATGGTAAAGGAGCTGGATGGTCATGTGCTCAAATGTGTGA
AAGATCAGAATGGAAACCATGTTGTACAAAAATGTATCGAATGTGTTCAGCCACAGTCACTACAGTTCATCATTGATGCTTTCAAGGGAC
AAGTATTTGTGCTTTCAACTCATCCTTATGGCTGCAGAGTAATTCAGCGCATCCTAGAGCATTGCACTGCAGAACAGACCTTACCTATCT
TAGAAGAACTCCACCAACATACAGAGCAGTTGGTACAGGATCAGTATGGCAATTATGTTATTCAGCATGTACTGGAACACGGTCGACCTG
AAGACAAGAGCAAAATTGTTTCCGAAATCAGGGGAAAGGTTTTAGCCCTGAGTCAACACAAATTTGCCAGCAATGTAGTAGAAAAGTGTG
TTACTCATGCCTCCCGTGCTGAGAGAGCTTTACTGATTGACGAGGTTTGCTGCCAGAATGATGGTCCTCACAGTGCCTTATACACCATGA
TGAAGGACCAGTATGCCAATTACGTGGTTCAAAAGATGATTGATATGGCTGAACCTGCTCAGAGAAAGATAATCATGCACAAGATTCGAC
CTCACATTACTACTTTGCGCAAATACACATACGGGAAGCATATACTGGCCAAGTTGGAAAAGTATTATTTGAAGAATAGCCCGGACCTAG
GACCTATTGGAGGACCACCAAATGGAATGCTGTAAATTACAGGAGCAAGAGAAAGAAGATAATTTAACCATGTGAAAAGAATTTTTTTGT
GTGTGAATTATCAAAACACAACTCAACTATGAATCTTCAATTTTTTTTTAAAGCAAAACTATTTATTGACTTTATTCATCCATTTGTAAA
TTTTTTAAGGTTCTTGTGTATATTTGGGGGGTGGGGGATGAATTATAAATTATATTCAGCCCTGAGTGGAGACCTATCAGATTGGATTGC

>In-frame_ENST00000262435_ENST00000403432_TCGA-HU-A4HD-01A_SMURF2_chr17_62574610_-_PUM2_chr2_20460227_length(amino acids)=608AA_start in transcript=188_stop in transcript=2014
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQG
AGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHIT
RTTQWERPTRPASEYSSPGRPLSCFVDENTPISGTNGATCGQSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFL
HTQTGVSTWHDPRVPRFIQQKLERATPAERQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVI
QKALESISSDQQSEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEE
LHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKD

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Fusion Gene PPI Analysis for SMURF2-PUM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePUM2chr17:62574609chr2:20460227ENST0000031980111191_260662.6666666666666988.0SNAPIN
TgenePUM2chr17:62574609chr2:20460227ENST0000033808612201_260741.66666666666661065.0SNAPIN
TgenePUM2chr17:62574609chr2:20460227ENST0000036107812201_260741.66666666666661067.0SNAPIN
TgenePUM2chr17:62574609chr2:20460227ENST0000040343213211_260741.66666666666661065.0SNAPIN
TgenePUM2chr17:62574610chr2:20460227ENST0000031980111191_260662.6666666666666988.0SNAPIN
TgenePUM2chr17:62574610chr2:20460227ENST0000033808612201_260741.66666666666661065.0SNAPIN
TgenePUM2chr17:62574610chr2:20460227ENST0000036107812201_260741.66666666666661067.0SNAPIN
TgenePUM2chr17:62574610chr2:20460227ENST0000040343213211_260741.66666666666661065.0SNAPIN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMURF2-PUM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMURF2-PUM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource