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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMYD3-COPA (FusionGDB2 ID:83786)

Fusion Gene Summary for SMYD3-COPA

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD3-COPA
Fusion gene ID: 83786
HgeneTgene
Gene symbol

SMYD3

COPA

Gene ID

64754

1314

Gene nameSET and MYND domain containing 3COPI coat complex subunit alpha
SynonymsKMT3E|ZMYND1|ZNFN3A1|bA74P14.1AILJK|HEP-COP|alpha-COP
Cytomap

1q44

1q23.2

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1coatomer subunit alphaalpha coat proteincoatomer protein complex subunit alphaproxeninxenin
Modification date2020032020200327
UniProtAcc.

P53621

Ensembl transtripts involved in fusion geneENST00000541742, ENST00000490107, 
ENST00000388985, ENST00000366517, 
ENST00000403792, 		ENST00000368069, 
ENST00000241704, 
Fusion gene scores* DoF score22 X 13 X 10=286012 X 9 X 8=864
# samples 2413
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD3 [Title/Abstract] AND COPA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMYD3(245927343)-COPA(160305112), # samples:3
Anticipated loss of major functional domain due to fusion event.SMYD3-COPA seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMYD3-COPA seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SMYD3-COPA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOPA

GO:0030157

pancreatic juice secretion

1429581


check buttonFusion gene breakpoints across SMYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5518-01ASMYD3chr1

245927343

-COPAchr1

160305112

-
ChimerDB4PRADTCGA-EJ-5518SMYD3chr1

245927343

-COPAchr1

160305112

-
ChimerDB4PRADTCGA-EJ-5518-01ASMYD3chr1

245927343

-COPAchr1

160305112

-


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Fusion Gene ORF analysis for SMYD3-COPA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000541742ENST00000368069SMYD3chr1

245927343

-COPAchr1

160305112

-
Frame-shiftENST00000541742ENST00000241704SMYD3chr1

245927343

-COPAchr1

160305112

-
In-frameENST00000490107ENST00000368069SMYD3chr1

245927343

-COPAchr1

160305112

-
In-frameENST00000490107ENST00000241704SMYD3chr1

245927343

-COPAchr1

160305112

-
In-frameENST00000388985ENST00000368069SMYD3chr1

245927343

-COPAchr1

160305112

-
In-frameENST00000388985ENST00000241704SMYD3chr1

245927343

-COPAchr1

160305112

-
5UTR-3CDSENST00000366517ENST00000368069SMYD3chr1

245927343

-COPAchr1

160305112

-
5UTR-3CDSENST00000366517ENST00000241704SMYD3chr1

245927343

-COPAchr1

160305112

-
intron-3CDSENST00000403792ENST00000368069SMYD3chr1

245927343

-COPAchr1

160305112

-
intron-3CDSENST00000403792ENST00000241704SMYD3chr1

245927343

-COPAchr1

160305112

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490107SMYD3chr1245927343-ENST00000368069COPAchr1160305112-558312251646981560
ENST00000490107SMYD3chr1245927343-ENST00000241704COPAchr1160305112-555612251646711551
ENST00000388985SMYD3chr1245927343-ENST00000368069COPAchr1160305112-55431185046581552
ENST00000388985SMYD3chr1245927343-ENST00000241704COPAchr1160305112-55161185046311543

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490107ENST00000368069SMYD3chr1245927343-COPAchr1160305112-0.000815310.99918467
ENST00000490107ENST00000241704SMYD3chr1245927343-COPAchr1160305112-0.0008970740.99910295
ENST00000388985ENST00000368069SMYD3chr1245927343-COPAchr1160305112-0.0007515630.99924845
ENST00000388985ENST00000241704SMYD3chr1245927343-COPAchr1160305112-0.0008254220.99917454

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Fusion Genomic Features for SMYD3-COPA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMYD3-COPA


check button Go to

FGviewer for the breakpoints of chr1:245927343-chr1:160305112

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COPA

P53621

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:245927343chr1:160305112ENST00000388985-11124_240395.0429.0DomainSET
HgeneSMYD3chr1:245927343chr1:160305112ENST00000490107-11124_240336.0370.0DomainSET
HgeneSMYD3chr1:245927343chr1:160305112ENST00000541742-11124_240336.0370.0DomainSET
HgeneSMYD3chr1:245927343chr1:160305112ENST00000388985-111214_16395.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000388985-1112205_206395.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000490107-111214_16336.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000490107-1112205_206336.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000541742-111214_16336.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000541742-1112205_206336.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:245927343chr1:160305112ENST00000388985-111249_87395.0429.0Zinc fingerMYND-type
HgeneSMYD3chr1:245927343chr1:160305112ENST00000490107-111249_87336.0370.0Zinc fingerMYND-type
HgeneSMYD3chr1:245927343chr1:160305112ENST00000541742-111249_87336.0370.0Zinc fingerMYND-type
TgeneCOPAchr1:245927343chr1:160305112ENST00000241704233126_16476.01225.0RepeatNote=WD 4
TgeneCOPAchr1:245927343chr1:160305112ENST00000241704233195_23476.01225.0RepeatNote=WD 5
TgeneCOPAchr1:245927343chr1:160305112ENST00000241704233241_27876.01225.0RepeatNote=WD 6
TgeneCOPAchr1:245927343chr1:160305112ENST00000241704233282_31976.01225.0RepeatNote=WD 7
TgeneCOPAchr1:245927343chr1:160305112ENST0000024170423384_12276.01225.0RepeatNote=WD 3
TgeneCOPAchr1:245927343chr1:160305112ENST00000368069233126_16476.01234.0RepeatNote=WD 4
TgeneCOPAchr1:245927343chr1:160305112ENST00000368069233195_23476.01234.0RepeatNote=WD 5
TgeneCOPAchr1:245927343chr1:160305112ENST00000368069233241_27876.01234.0RepeatNote=WD 6
TgeneCOPAchr1:245927343chr1:160305112ENST00000368069233282_31976.01234.0RepeatNote=WD 7
TgeneCOPAchr1:245927343chr1:160305112ENST0000036806923384_12276.01234.0RepeatNote=WD 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCOPAchr1:245927343chr1:160305112ENST000002417042333_3876.01225.0RepeatNote=WD 1
TgeneCOPAchr1:245927343chr1:160305112ENST0000024170423342_8076.01225.0RepeatNote=WD 2
TgeneCOPAchr1:245927343chr1:160305112ENST000003680692333_3876.01234.0RepeatNote=WD 1
TgeneCOPAchr1:245927343chr1:160305112ENST0000036806923342_8076.01234.0RepeatNote=WD 2


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Fusion Gene Sequence for SMYD3-COPA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000490107_ENST00000368069_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(transcript)=5583nt_BP=1225nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCT
ATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCG
AGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTA
CTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCA
AGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTC
TGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGC
CTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGG
CAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGTTTGGAATTACAAGCTTCGGCGCTGTCTTTTCAC
ATTGCTTGGGCACTTAGATTATATTCGCACCACGTTTTTTCATCATGAATATCCCTGGATTCTGAGTGCCTCCGATGATCAGACCATCCG
AGTGTGGAACTGGCAATCTAGAACCTGTGTTTGTGTGTTAACAGGGCACAACCATTATGTGATGTGTGCTCAGTTCCACCCCACAGAAGA
CTTGGTAGTATCAGCCAGCCTGGACCAGACTGTGCGCGTTTGGGATATTTCTGGTCTGAGGAAAAAAAACCTGTCCCCTGGTGCGGTGGA
ATCGGATGTGAGAGGAATAACTGGGGTTGATCTATTTGGAACTACAGATGCAGTGGTGAAGCATGTACTAGAGGGTCACGATCGTGGAGT
AAACTGGGCTGCCTTCCACCCCACTATGCCCCTTATTGTATCTGGGGCAGATGATCGTCAAGTGAAGATCTGGCGCATGAATGAATCAAA
GGCATGGGAGGTTGATACCTGCCGGGGCCATTACAACAATGTATCTTGTGCCGTCTTCCACCCTCGCCAAGAGTTGATCCTCAGCAATTC
TGAGGACAAGAGTATTCGAGTCTGGGATATGTCTAAGCGGACTGGGGTTCAGACTTTCCGCAGAGACCATGATCGTTTCTGGGTCCTAGC
TGCTCACCCTAACCTTAACCTCTTTGCAGCAGGCCATGATGGTGGTATGATTGTGTTTAAGCTGGAACGGGAACGGCCAGCCTATGCTGT
TCATGGCAATATGCTACACTATGTCAAGGACCGATTCTTACGACAGCTGGATTTCAACAGCTCCAAAGATGTAGCTGTGATGCAGTTGCG
GAGTGGTTCCAAGTTTCCAGTATTCAATATGTCATACAATCCAGCAGAAAATGCAGTCCTGCTTTGTACAAGAGCTAGCAATCTAGAGAA
TAGTACCTATGACCTGTACACCATCCCTAAAGATGCTGACTCCCAGAATCCTGATGCGCCTGAAGGGAAACGATCCTCAGGCCTGACAGC
CGTTTGGGTCGCTCGAAATCGGTTTGCTGTCCTAGATCGGATGCATTCGCTTCTGATCAAGAATCTGAAGAATGAGATCACCAAAAAGGT
ACAGGTGCCCAACTGTGATGAGATCTTCTATGCTGGCACAGGCAATCTCCTGCTTCGAGATGCGGACTCTATCACACTCTTTGACGTACA
GCAGAAGCGGACTCTGGCATCTGTGAAGATTTCTAAAGTGAAATACGTTATCTGGTCAGCAGACATGTCACATGTAGCACTACTAGCCAA
ACACGAACACTCATGCCCTTTGCCTCTTACAGCCATTGTGATCTGTAACCGCAAACTGGATGCTTTATGTAACATTCATGAGAACATTCG
TGTCAAGAGTGGGGCCTGGGATGAGAGTGGGGTATTTATCTATACCACAAGCAACCACATCAAATATGCTGTCACCACTGGGGACCACGG
GATCATTCGAACTCTGGATTTACCCATCTATGTCACACGGGTGAAGGGCAACAATGTATACTGCCTAGACAGGGAGTGTCGTCCCCGGGT
ACTCACCATTGATCCCACTGAGTTCAAATTCAAGCTGGCCCTGATCAACAGAAAATATGATGAGGTACTGCACATGGTGAGGAATGCCAA
ACTAGTTGGCCAGTCTATTATTGCTTATCTCCAGAAGAAGGGCTATCCTGAAGTGGCACTGCATTTTGTCAAGGATGAGAAAACTCGCTT
TAGTCTGGCACTGGAGTGTGGAAACATTGAGATTGCTCTGGAAGCAGCCAAAGCACTGGATGACAAGAACTGCTGGGAAAAGCTGGGAGA
AGTGGCCCTGCTGCAGGGGAACCACCAGATTGTGGAAATGTGCTATCAGCGTACCAAAAACTTTGACAAACTTTCCTTCCTGTATCTTAT
CACTGGCAACTTAGAAAAACTTCGCAAGATGATGAAGATTGCTGAGATCAGAAAGGACATGAGTGGCCACTATCAGAATGCCCTATACCT
GGGTGATGTGTCAGAGCGTGTGCGGATCCTGAAGAACTGTGGACAGAAGTCCCTGGCCTATCTCACAGCTGCTACCCATGGCTTAGATGA
AGAAGCTGAGAGCCTAAAGGAGACATTTGACCCAGAGAAGGAGACAATCCCAGACATTGACCCTAATGCCAAGCTGCTCCAGCCACCTGC
ACCTATCATGCCATTGGATACCAATTGGCCTTTATTGACTGTATCCAAAGGATTTTTTGAAGGCACCATTGCCAGCAAAGGGAAGGGAGG
AGCACTGGCTGCTGACATTGACATTGACACTGTTGGTACAGAGGGCTGGGGAGAGGATGCAGAGCTGCAGTTGGATGAAGATGGGTTTGT
GGAGGCTACAGAAGGTTTGGGGGATGATGCTCTTGGCAAGGGACAGGAAGAAGGAGGTGGCTGGGATGTAGAAGAAGATCTGGAGCTCCC
TCCTGAGCTGGATATATCCCCTGGGGCAGCTGGTGGGGCTGAAGATGGTTTCTTTGTGCCCCCAACCAAGGGAACAAGTCCAACTCAGAT
CTGGTGTAATAACTCTCAGCTTCCAGTTGATCACATCCTGGCAGGCTCTTTCGAAACAGCCATGCGGCTCCTTCATGACCAAGTAGGGGT
AATCCAGTTTGGCCCCTACAAGCAACTGTTCCTACAGACATACGCCCGAGGCCGCACAACCTATCAGGCTCTGCCCTGCCTACCCTCCAT
GTATGGCTATCCTAATCGCAACTGGAAGGATGCAGGGCTGAAGAATGGTGTACCAGCTGTGGGCCTGAAGCTTAATGACCTCATCCAACG
GTTGCAGCTGTGCTACCAGCTCACCACAGTTGGCAAATTTGAGGAGGCTGTGGAAAAATTCCGTTCCATCCTTCTCAGTGTGCCACTTCT
TGTTGTGGACAATAAACAAGAGATTGCAGAGGCCCAGCAGCTCATCACCATTTGCCGTGAGTACATTGTGGGTTTGTCCGTGGAGACAGA
AAGGAAGAAGCTGCCCAAAGAGACTCTAGAACAGCAGAAGCGCATCTGTGAGATGGCAGCCTATTTCACCCACTCAAACCTGCAGCCTGT
GCACATGATCCTGGTGCTGCGTACAGCCCTCAATCTGTTCTTCAAGCTCAAGAACTTCAAGACAGCTGCCACCTTTGCTCGGCGCCTACT
AGAACTCGGGCCCAAGCCTGAGGTGGCCCAACAGACCCGAAAAATCCTGTCTGCCTGTGAGAAGAATCCCACAGATGCCTACCAGCTCAA
TTATGACATGCACAACCCCTTTGACATTTGTGCTGCATCATATCGGCCCATCTACCGTGGAAAGCCAGTAGAAAAGTGTCCACTCAGTGG
GGCCTGCTATTCCCCTGAGTTCAAAGGTCAAATCTGCAGGGTCACCACAGTGACAGAGATTGGCAAAGATGTGATTGGTTTAAGGATCAG
TCCTCTGCAGTTTCGCTAAGGCCCCCTTTGTGTGCATGGGTCAGTCACCATATGTTCCCCCCAGAGAATGTGTCTATATCCTCCTTCTAA
CAGCACCTTCCCCCTGCAGCTACTCTTCAGATCTGGCTCTCTGTACCCTAAAACCTAGTATCTTTTTCTCTTCTATGGAAAATCCGAAGG
TCTAAACTTGACTTTTTTGAGGTCTTCTCAACTTGACTACAGTTGTGCTCATAATTGTCCTTGCCTTTCCAGCTTAATTATTTTAAGGAA
CAAATGAAAACTCTGGGCTGGGTGGAGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTACGGTGGGCAGATCATCTGAGGCCAGG
AGTTCGAGACCTGCCTGGCCAACATGGCAACACCCCGTCTCTAATAAAAATATAAAAATTAGCCTGGCATGGTAGCATGCGCCTATAGTC
CCAGCTGCTCAGGAGGCTGAGGCATGAGAATCGCTTGAACCTAGGAGGTGGAGGTTGCATTCAACTGAGATCATACCACTTCATTCCAGC
CTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGGAAAACTCTGTGATGGACATTTGTTTAGTAAATCCCTTCAGTATTTAT
CCCTCCTTTCCCCACAGCAGCTTTCTTTCCTGTCAACTAGAAAGGAGCAGGATGTAATAAATACATTTTGGTGTGACTAGGCCACACCAA
CTCTTAATCATCTCCCATTTTCCTTAGACATTTAAATTTCAAGGCAGGTACCCTCTGTGTACTCAGAAATTTGAAGAAGTTATTTGGTTT
TCCAAAATGCACACTGCGGGTTATTGATTTGTTCTTTACAACTATTGTTCTCATATTTCTCACACTAAATAAATCTCTATGAGAGCTTCT

>In-frame_ENST00000490107_ENST00000368069_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(amino acids)=1560AA_start in transcript=16_stop in transcript=4698
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPD
HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLF
EAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECD
CFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGT
RTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ
SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAF
HPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNL
NLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDL
YTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTL
ASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTL
DLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALE
CGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSE
RVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAAD
IDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNS
QLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCY
QLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILV
LRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSP

--------------------------------------------------------------
>In-frame_ENST00000490107_ENST00000241704_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(transcript)=5556nt_BP=1225nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTGATCTGCAACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCT
ATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCCAACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCG
AGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTGGATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTA
CTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGACAAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCA
AGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGGAAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTC
TGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTGCTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGC
CTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATTTTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGG
CAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATGAAGAATCTGAGACTGGTTTGGAATTACAAGCTTCGGCGCTGTCTTTTCAC
ATTGCTTGGGCACTTAGATTATATTCGCACCACGTTTTTTCATCATGAATATCCCTGGATTCTGAGTGCCTCCGATGATCAGACCATCCG
AGTGTGGAACTGGCAATCTAGAACCTGTGTTTGTGTGTTAACAGGGCACAACCATTATGTGATGTGTGCTCAGTTCCACCCCACAGAAGA
CTTGGTAGTATCAGCCAGCCTGGACCAGACTGTGCGCGTTTGGGATATTTCTGGTCTGAGGAAAAAAAACCTGTCCCCTGGTGCGGTGGA
ATCGGATGTGAGAGGAATAACTGGGGTTGATCTATTTGGAACTACAGATGCAGTGGTGAAGCATGTACTAGAGGGTCACGATCGTGGAGT
AAACTGGGCTGCCTTCCACCCCACTATGCCCCTTATTGTATCTGGGGCAGATGATCGTCAAGTGAAGATCTGGCGCATGAATGAATCAAA
GGCATGGGAGGTTGATACCTGCCGGGGCCATTACAACAATGTATCTTGTGCCGTCTTCCACCCTCGCCAAGAGTTGATCCTCAGCAATTC
TGAGGACAAGAGTATTCGAGTCTGGGATATGTCTAAGCGGACTGGGGTTCAGACTTTCCGCAGAGACCATGATCGTTTCTGGGTCCTAGC
TGCTCACCCTAACCTTAACCTCTTTGCAGCAGGCCATGATGGTGGTATGATTGTGTTTAAGCTGGAACGGGAACGGCCAGCCTATGCTGT
TCATGGCAATATGCTACACTATGTCAAGGACCGATTCTTACGACAGCTGGATTTCAACAGCTCCAAAGATGTAGCTGTGATGCAGTTGCG
GAGTGGTTCCAAGTTTCCAGTATTCAATATGTCATACAATCCAGCAGAAAATGCAGTCCTGCTTTGTACAAGAGCTAGCAATCTAGAGAA
TAGTACCTATGACCTGTACACCATCCCTAAAGATGCTGACTCCCAGAATCCTGATGCGCCTGAAGGGAAACGATCCTCAGGCCTGACAGC
CGTTTGGGTCGCTCGAAATCGGTTTGCTGTCCTAGATCGGATGCATTCGCTTCTGATCAAGAATCTGAAGAATGAGATCACCAAAAAGGT
ACAGGTGCCCAACTGTGATGAGATCTTCTATGCTGGCACAGGCAATCTCCTGCTTCGAGATGCGGACTCTATCACACTCTTTGACGTACA
GCAGAAGCGGACTCTGGCATCTGTGAAGATTTCTAAAGTGAAATACGTTATCTGGTCAGCAGACATGTCACATGTAGCACTACTAGCCAA
ACACGCCATTGTGATCTGTAACCGCAAACTGGATGCTTTATGTAACATTCATGAGAACATTCGTGTCAAGAGTGGGGCCTGGGATGAGAG
TGGGGTATTTATCTATACCACAAGCAACCACATCAAATATGCTGTCACCACTGGGGACCACGGGATCATTCGAACTCTGGATTTACCCAT
CTATGTCACACGGGTGAAGGGCAACAATGTATACTGCCTAGACAGGGAGTGTCGTCCCCGGGTACTCACCATTGATCCCACTGAGTTCAA
ATTCAAGCTGGCCCTGATCAACAGAAAATATGATGAGGTACTGCACATGGTGAGGAATGCCAAACTAGTTGGCCAGTCTATTATTGCTTA
TCTCCAGAAGAAGGGCTATCCTGAAGTGGCACTGCATTTTGTCAAGGATGAGAAAACTCGCTTTAGTCTGGCACTGGAGTGTGGAAACAT
TGAGATTGCTCTGGAAGCAGCCAAAGCACTGGATGACAAGAACTGCTGGGAAAAGCTGGGAGAAGTGGCCCTGCTGCAGGGGAACCACCA
GATTGTGGAAATGTGCTATCAGCGTACCAAAAACTTTGACAAACTTTCCTTCCTGTATCTTATCACTGGCAACTTAGAAAAACTTCGCAA
GATGATGAAGATTGCTGAGATCAGAAAGGACATGAGTGGCCACTATCAGAATGCCCTATACCTGGGTGATGTGTCAGAGCGTGTGCGGAT
CCTGAAGAACTGTGGACAGAAGTCCCTGGCCTATCTCACAGCTGCTACCCATGGCTTAGATGAAGAAGCTGAGAGCCTAAAGGAGACATT
TGACCCAGAGAAGGAGACAATCCCAGACATTGACCCTAATGCCAAGCTGCTCCAGCCACCTGCACCTATCATGCCATTGGATACCAATTG
GCCTTTATTGACTGTATCCAAAGGATTTTTTGAAGGCACCATTGCCAGCAAAGGGAAGGGAGGAGCACTGGCTGCTGACATTGACATTGA
CACTGTTGGTACAGAGGGCTGGGGAGAGGATGCAGAGCTGCAGTTGGATGAAGATGGGTTTGTGGAGGCTACAGAAGGTTTGGGGGATGA
TGCTCTTGGCAAGGGACAGGAAGAAGGAGGTGGCTGGGATGTAGAAGAAGATCTGGAGCTCCCTCCTGAGCTGGATATATCCCCTGGGGC
AGCTGGTGGGGCTGAAGATGGTTTCTTTGTGCCCCCAACCAAGGGAACAAGTCCAACTCAGATCTGGTGTAATAACTCTCAGCTTCCAGT
TGATCACATCCTGGCAGGCTCTTTCGAAACAGCCATGCGGCTCCTTCATGACCAAGTAGGGGTAATCCAGTTTGGCCCCTACAAGCAACT
GTTCCTACAGACATACGCCCGAGGCCGCACAACCTATCAGGCTCTGCCCTGCCTACCCTCCATGTATGGCTATCCTAATCGCAACTGGAA
GGATGCAGGGCTGAAGAATGGTGTACCAGCTGTGGGCCTGAAGCTTAATGACCTCATCCAACGGTTGCAGCTGTGCTACCAGCTCACCAC
AGTTGGCAAATTTGAGGAGGCTGTGGAAAAATTCCGTTCCATCCTTCTCAGTGTGCCACTTCTTGTTGTGGACAATAAACAAGAGATTGC
AGAGGCCCAGCAGCTCATCACCATTTGCCGTGAGTACATTGTGGGTTTGTCCGTGGAGACAGAAAGGAAGAAGCTGCCCAAAGAGACTCT
AGAACAGCAGAAGCGCATCTGTGAGATGGCAGCCTATTTCACCCACTCAAACCTGCAGCCTGTGCACATGATCCTGGTGCTGCGTACAGC
CCTCAATCTGTTCTTCAAGCTCAAGAACTTCAAGACAGCTGCCACCTTTGCTCGGCGCCTACTAGAACTCGGGCCCAAGCCTGAGGTGGC
CCAACAGACCCGAAAAATCCTGTCTGCCTGTGAGAAGAATCCCACAGATGCCTACCAGCTCAATTATGACATGCACAACCCCTTTGACAT
TTGTGCTGCATCATATCGGCCCATCTACCGTGGAAAGCCAGTAGAAAAGTGTCCACTCAGTGGGGCCTGCTATTCCCCTGAGTTCAAAGG
TCAAATCTGCAGGGTCACCACAGTGACAGAGATTGGCAAAGATGTGATTGGTTTAAGGATCAGTCCTCTGCAGTTTCGCTAAGGCCCCCT
TTGTGTGCATGGGTCAGTCACCATATGTTCCCCCCAGAGAATGTGTCTATATCCTCCTTCTAACAGCACCTTCCCCCTGCAGCTACTCTT
CAGATCTGGCTCTCTGTACCCTAAAACCTAGTATCTTTTTCTCTTCTATGGAAAATCCGAAGGTCTAAACTTGACTTTTTTGAGGTCTTC
TCAACTTGACTACAGTTGTGCTCATAATTGTCCTTGCCTTTCCAGCTTAATTATTTTAAGGAACAAATGAAAACTCTGGGCTGGGTGGAG
TGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTACGGTGGGCAGATCATCTGAGGCCAGGAGTTCGAGACCTGCCTGGCCAACATGG
CAACACCCCGTCTCTAATAAAAATATAAAAATTAGCCTGGCATGGTAGCATGCGCCTATAGTCCCAGCTGCTCAGGAGGCTGAGGCATGA
GAATCGCTTGAACCTAGGAGGTGGAGGTTGCATTCAACTGAGATCATACCACTTCATTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTC
AAAAAAAAAAAAAAGGAAAACTCTGTGATGGACATTTGTTTAGTAAATCCCTTCAGTATTTATCCCTCCTTTCCCCACAGCAGCTTTCTT
TCCTGTCAACTAGAAAGGAGCAGGATGTAATAAATACATTTTGGTGTGACTAGGCCACACCAACTCTTAATCATCTCCCATTTTCCTTAG
ACATTTAAATTTCAAGGCAGGTACCCTCTGTGTACTCAGAAATTTGAAGAAGTTATTTGGTTTTCCAAAATGCACACTGCGGGTTATTGA

>In-frame_ENST00000490107_ENST00000241704_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(amino acids)=1551AA_start in transcript=16_stop in transcript=4671
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPD
HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLF
EAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECD
CFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGT
RTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQ
SRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAF
HPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNL
NLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDL
YTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTL
ASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRV
KGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALE
AAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCG
QKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTE
GWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILA
GSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFE
EAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFF
KLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRV

--------------------------------------------------------------
>In-frame_ENST00000388985_ENST00000368069_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(transcript)=5543nt_BP=1185nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTGATCTGC
AACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCC
AACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTG
GATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGAC
AAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGG
AAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTG
CTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATT
TTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATG
AAGAATCTGAGACTGGTTTGGAATTACAAGCTTCGGCGCTGTCTTTTCACATTGCTTGGGCACTTAGATTATATTCGCACCACGTTTTTT
CATCATGAATATCCCTGGATTCTGAGTGCCTCCGATGATCAGACCATCCGAGTGTGGAACTGGCAATCTAGAACCTGTGTTTGTGTGTTA
ACAGGGCACAACCATTATGTGATGTGTGCTCAGTTCCACCCCACAGAAGACTTGGTAGTATCAGCCAGCCTGGACCAGACTGTGCGCGTT
TGGGATATTTCTGGTCTGAGGAAAAAAAACCTGTCCCCTGGTGCGGTGGAATCGGATGTGAGAGGAATAACTGGGGTTGATCTATTTGGA
ACTACAGATGCAGTGGTGAAGCATGTACTAGAGGGTCACGATCGTGGAGTAAACTGGGCTGCCTTCCACCCCACTATGCCCCTTATTGTA
TCTGGGGCAGATGATCGTCAAGTGAAGATCTGGCGCATGAATGAATCAAAGGCATGGGAGGTTGATACCTGCCGGGGCCATTACAACAAT
GTATCTTGTGCCGTCTTCCACCCTCGCCAAGAGTTGATCCTCAGCAATTCTGAGGACAAGAGTATTCGAGTCTGGGATATGTCTAAGCGG
ACTGGGGTTCAGACTTTCCGCAGAGACCATGATCGTTTCTGGGTCCTAGCTGCTCACCCTAACCTTAACCTCTTTGCAGCAGGCCATGAT
GGTGGTATGATTGTGTTTAAGCTGGAACGGGAACGGCCAGCCTATGCTGTTCATGGCAATATGCTACACTATGTCAAGGACCGATTCTTA
CGACAGCTGGATTTCAACAGCTCCAAAGATGTAGCTGTGATGCAGTTGCGGAGTGGTTCCAAGTTTCCAGTATTCAATATGTCATACAAT
CCAGCAGAAAATGCAGTCCTGCTTTGTACAAGAGCTAGCAATCTAGAGAATAGTACCTATGACCTGTACACCATCCCTAAAGATGCTGAC
TCCCAGAATCCTGATGCGCCTGAAGGGAAACGATCCTCAGGCCTGACAGCCGTTTGGGTCGCTCGAAATCGGTTTGCTGTCCTAGATCGG
ATGCATTCGCTTCTGATCAAGAATCTGAAGAATGAGATCACCAAAAAGGTACAGGTGCCCAACTGTGATGAGATCTTCTATGCTGGCACA
GGCAATCTCCTGCTTCGAGATGCGGACTCTATCACACTCTTTGACGTACAGCAGAAGCGGACTCTGGCATCTGTGAAGATTTCTAAAGTG
AAATACGTTATCTGGTCAGCAGACATGTCACATGTAGCACTACTAGCCAAACACGAACACTCATGCCCTTTGCCTCTTACAGCCATTGTG
ATCTGTAACCGCAAACTGGATGCTTTATGTAACATTCATGAGAACATTCGTGTCAAGAGTGGGGCCTGGGATGAGAGTGGGGTATTTATC
TATACCACAAGCAACCACATCAAATATGCTGTCACCACTGGGGACCACGGGATCATTCGAACTCTGGATTTACCCATCTATGTCACACGG
GTGAAGGGCAACAATGTATACTGCCTAGACAGGGAGTGTCGTCCCCGGGTACTCACCATTGATCCCACTGAGTTCAAATTCAAGCTGGCC
CTGATCAACAGAAAATATGATGAGGTACTGCACATGGTGAGGAATGCCAAACTAGTTGGCCAGTCTATTATTGCTTATCTCCAGAAGAAG
GGCTATCCTGAAGTGGCACTGCATTTTGTCAAGGATGAGAAAACTCGCTTTAGTCTGGCACTGGAGTGTGGAAACATTGAGATTGCTCTG
GAAGCAGCCAAAGCACTGGATGACAAGAACTGCTGGGAAAAGCTGGGAGAAGTGGCCCTGCTGCAGGGGAACCACCAGATTGTGGAAATG
TGCTATCAGCGTACCAAAAACTTTGACAAACTTTCCTTCCTGTATCTTATCACTGGCAACTTAGAAAAACTTCGCAAGATGATGAAGATT
GCTGAGATCAGAAAGGACATGAGTGGCCACTATCAGAATGCCCTATACCTGGGTGATGTGTCAGAGCGTGTGCGGATCCTGAAGAACTGT
GGACAGAAGTCCCTGGCCTATCTCACAGCTGCTACCCATGGCTTAGATGAAGAAGCTGAGAGCCTAAAGGAGACATTTGACCCAGAGAAG
GAGACAATCCCAGACATTGACCCTAATGCCAAGCTGCTCCAGCCACCTGCACCTATCATGCCATTGGATACCAATTGGCCTTTATTGACT
GTATCCAAAGGATTTTTTGAAGGCACCATTGCCAGCAAAGGGAAGGGAGGAGCACTGGCTGCTGACATTGACATTGACACTGTTGGTACA
GAGGGCTGGGGAGAGGATGCAGAGCTGCAGTTGGATGAAGATGGGTTTGTGGAGGCTACAGAAGGTTTGGGGGATGATGCTCTTGGCAAG
GGACAGGAAGAAGGAGGTGGCTGGGATGTAGAAGAAGATCTGGAGCTCCCTCCTGAGCTGGATATATCCCCTGGGGCAGCTGGTGGGGCT
GAAGATGGTTTCTTTGTGCCCCCAACCAAGGGAACAAGTCCAACTCAGATCTGGTGTAATAACTCTCAGCTTCCAGTTGATCACATCCTG
GCAGGCTCTTTCGAAACAGCCATGCGGCTCCTTCATGACCAAGTAGGGGTAATCCAGTTTGGCCCCTACAAGCAACTGTTCCTACAGACA
TACGCCCGAGGCCGCACAACCTATCAGGCTCTGCCCTGCCTACCCTCCATGTATGGCTATCCTAATCGCAACTGGAAGGATGCAGGGCTG
AAGAATGGTGTACCAGCTGTGGGCCTGAAGCTTAATGACCTCATCCAACGGTTGCAGCTGTGCTACCAGCTCACCACAGTTGGCAAATTT
GAGGAGGCTGTGGAAAAATTCCGTTCCATCCTTCTCAGTGTGCCACTTCTTGTTGTGGACAATAAACAAGAGATTGCAGAGGCCCAGCAG
CTCATCACCATTTGCCGTGAGTACATTGTGGGTTTGTCCGTGGAGACAGAAAGGAAGAAGCTGCCCAAAGAGACTCTAGAACAGCAGAAG
CGCATCTGTGAGATGGCAGCCTATTTCACCCACTCAAACCTGCAGCCTGTGCACATGATCCTGGTGCTGCGTACAGCCCTCAATCTGTTC
TTCAAGCTCAAGAACTTCAAGACAGCTGCCACCTTTGCTCGGCGCCTACTAGAACTCGGGCCCAAGCCTGAGGTGGCCCAACAGACCCGA
AAAATCCTGTCTGCCTGTGAGAAGAATCCCACAGATGCCTACCAGCTCAATTATGACATGCACAACCCCTTTGACATTTGTGCTGCATCA
TATCGGCCCATCTACCGTGGAAAGCCAGTAGAAAAGTGTCCACTCAGTGGGGCCTGCTATTCCCCTGAGTTCAAAGGTCAAATCTGCAGG
GTCACCACAGTGACAGAGATTGGCAAAGATGTGATTGGTTTAAGGATCAGTCCTCTGCAGTTTCGCTAAGGCCCCCTTTGTGTGCATGGG
TCAGTCACCATATGTTCCCCCCAGAGAATGTGTCTATATCCTCCTTCTAACAGCACCTTCCCCCTGCAGCTACTCTTCAGATCTGGCTCT
CTGTACCCTAAAACCTAGTATCTTTTTCTCTTCTATGGAAAATCCGAAGGTCTAAACTTGACTTTTTTGAGGTCTTCTCAACTTGACTAC
AGTTGTGCTCATAATTGTCCTTGCCTTTCCAGCTTAATTATTTTAAGGAACAAATGAAAACTCTGGGCTGGGTGGAGTGGCTCATACCTG
TAATCCCAGCACTTTGGGAGGCTACGGTGGGCAGATCATCTGAGGCCAGGAGTTCGAGACCTGCCTGGCCAACATGGCAACACCCCGTCT
CTAATAAAAATATAAAAATTAGCCTGGCATGGTAGCATGCGCCTATAGTCCCAGCTGCTCAGGAGGCTGAGGCATGAGAATCGCTTGAAC
CTAGGAGGTGGAGGTTGCATTCAACTGAGATCATACCACTTCATTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAA
AGGAAAACTCTGTGATGGACATTTGTTTAGTAAATCCCTTCAGTATTTATCCCTCCTTTCCCCACAGCAGCTTTCTTTCCTGTCAACTAG
AAAGGAGCAGGATGTAATAAATACATTTTGGTGTGACTAGGCCACACCAACTCTTAATCATCTCCCATTTTCCTTAGACATTTAAATTTC
AAGGCAGGTACCCTCTGTGTACTCAGAAATTTGAAGAAGTTATTTGGTTTTCCAAAATGCACACTGCGGGTTATTGATTTGTTCTTTACA

>In-frame_ENST00000388985_ENST00000368069_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(amino acids)=1552AA_start in transcript=0_stop in transcript=4658
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQD
KDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL
TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIV
SGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD
GGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDAD
SQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKV
KYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTR
VKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIAL
EAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNC
GQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGT
EGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHIL
AGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKF
EEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLF
FKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICR

--------------------------------------------------------------
>In-frame_ENST00000388985_ENST00000241704_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(transcript)=5516nt_BP=1185nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTGATCTGC
AACTCTTTCACCATCTGTAATGCGGAGATGCAGGAAGTTGGTGTTGGCCTATATCCCAGTATCTCTTTGCTCAATCACAGCTGTGACCCC
AACTGTTCGATTGTGTTCAATGGGCCCCACCTCTTACTGCGAGCAGTCCGAGACATCGAGGTGGGAGAGGAGCTCACCATCTGCTACCTG
GATATGCTGATGACCAGTGAGGAGCGCCGGAAGCAGCTGAGGGACCAGTACTGCTTTGAATGTGACTGTTTCCGTTGCCAAACCCAGGAC
AAGGATGCTGATATGCTAACTGGTGATGAGCAAGTATGGAAGGAAGTTCAAGAATCCCTGAAAAAAATTGAAGAACTGAAGGCACACTGG
AAGTGGGAGCAGGTTCTGGCCATGTGCCAGGCAATCATAAGCAGCAATTCTGAACGGCTTCCCGATATCAACATCTACCAGCTGAAGGTG
CTCGACTGCGCCATGGATGCCTGCATCAACCTCGGCCTGTTGGAGGAAGCCTTGTTCTATGGTACTCGGACCATGGAGCCATACAGGATT
TTTTTCCCAGGAAGCCATCCCGTCAGAGGGGTTCAAGTGATGAAAGTTGGCAAACTGCAGCTACATCAAGGCATGTTTCCCCAAGCAATG
AAGAATCTGAGACTGGTTTGGAATTACAAGCTTCGGCGCTGTCTTTTCACATTGCTTGGGCACTTAGATTATATTCGCACCACGTTTTTT
CATCATGAATATCCCTGGATTCTGAGTGCCTCCGATGATCAGACCATCCGAGTGTGGAACTGGCAATCTAGAACCTGTGTTTGTGTGTTA
ACAGGGCACAACCATTATGTGATGTGTGCTCAGTTCCACCCCACAGAAGACTTGGTAGTATCAGCCAGCCTGGACCAGACTGTGCGCGTT
TGGGATATTTCTGGTCTGAGGAAAAAAAACCTGTCCCCTGGTGCGGTGGAATCGGATGTGAGAGGAATAACTGGGGTTGATCTATTTGGA
ACTACAGATGCAGTGGTGAAGCATGTACTAGAGGGTCACGATCGTGGAGTAAACTGGGCTGCCTTCCACCCCACTATGCCCCTTATTGTA
TCTGGGGCAGATGATCGTCAAGTGAAGATCTGGCGCATGAATGAATCAAAGGCATGGGAGGTTGATACCTGCCGGGGCCATTACAACAAT
GTATCTTGTGCCGTCTTCCACCCTCGCCAAGAGTTGATCCTCAGCAATTCTGAGGACAAGAGTATTCGAGTCTGGGATATGTCTAAGCGG
ACTGGGGTTCAGACTTTCCGCAGAGACCATGATCGTTTCTGGGTCCTAGCTGCTCACCCTAACCTTAACCTCTTTGCAGCAGGCCATGAT
GGTGGTATGATTGTGTTTAAGCTGGAACGGGAACGGCCAGCCTATGCTGTTCATGGCAATATGCTACACTATGTCAAGGACCGATTCTTA
CGACAGCTGGATTTCAACAGCTCCAAAGATGTAGCTGTGATGCAGTTGCGGAGTGGTTCCAAGTTTCCAGTATTCAATATGTCATACAAT
CCAGCAGAAAATGCAGTCCTGCTTTGTACAAGAGCTAGCAATCTAGAGAATAGTACCTATGACCTGTACACCATCCCTAAAGATGCTGAC
TCCCAGAATCCTGATGCGCCTGAAGGGAAACGATCCTCAGGCCTGACAGCCGTTTGGGTCGCTCGAAATCGGTTTGCTGTCCTAGATCGG
ATGCATTCGCTTCTGATCAAGAATCTGAAGAATGAGATCACCAAAAAGGTACAGGTGCCCAACTGTGATGAGATCTTCTATGCTGGCACA
GGCAATCTCCTGCTTCGAGATGCGGACTCTATCACACTCTTTGACGTACAGCAGAAGCGGACTCTGGCATCTGTGAAGATTTCTAAAGTG
AAATACGTTATCTGGTCAGCAGACATGTCACATGTAGCACTACTAGCCAAACACGCCATTGTGATCTGTAACCGCAAACTGGATGCTTTA
TGTAACATTCATGAGAACATTCGTGTCAAGAGTGGGGCCTGGGATGAGAGTGGGGTATTTATCTATACCACAAGCAACCACATCAAATAT
GCTGTCACCACTGGGGACCACGGGATCATTCGAACTCTGGATTTACCCATCTATGTCACACGGGTGAAGGGCAACAATGTATACTGCCTA
GACAGGGAGTGTCGTCCCCGGGTACTCACCATTGATCCCACTGAGTTCAAATTCAAGCTGGCCCTGATCAACAGAAAATATGATGAGGTA
CTGCACATGGTGAGGAATGCCAAACTAGTTGGCCAGTCTATTATTGCTTATCTCCAGAAGAAGGGCTATCCTGAAGTGGCACTGCATTTT
GTCAAGGATGAGAAAACTCGCTTTAGTCTGGCACTGGAGTGTGGAAACATTGAGATTGCTCTGGAAGCAGCCAAAGCACTGGATGACAAG
AACTGCTGGGAAAAGCTGGGAGAAGTGGCCCTGCTGCAGGGGAACCACCAGATTGTGGAAATGTGCTATCAGCGTACCAAAAACTTTGAC
AAACTTTCCTTCCTGTATCTTATCACTGGCAACTTAGAAAAACTTCGCAAGATGATGAAGATTGCTGAGATCAGAAAGGACATGAGTGGC
CACTATCAGAATGCCCTATACCTGGGTGATGTGTCAGAGCGTGTGCGGATCCTGAAGAACTGTGGACAGAAGTCCCTGGCCTATCTCACA
GCTGCTACCCATGGCTTAGATGAAGAAGCTGAGAGCCTAAAGGAGACATTTGACCCAGAGAAGGAGACAATCCCAGACATTGACCCTAAT
GCCAAGCTGCTCCAGCCACCTGCACCTATCATGCCATTGGATACCAATTGGCCTTTATTGACTGTATCCAAAGGATTTTTTGAAGGCACC
ATTGCCAGCAAAGGGAAGGGAGGAGCACTGGCTGCTGACATTGACATTGACACTGTTGGTACAGAGGGCTGGGGAGAGGATGCAGAGCTG
CAGTTGGATGAAGATGGGTTTGTGGAGGCTACAGAAGGTTTGGGGGATGATGCTCTTGGCAAGGGACAGGAAGAAGGAGGTGGCTGGGAT
GTAGAAGAAGATCTGGAGCTCCCTCCTGAGCTGGATATATCCCCTGGGGCAGCTGGTGGGGCTGAAGATGGTTTCTTTGTGCCCCCAACC
AAGGGAACAAGTCCAACTCAGATCTGGTGTAATAACTCTCAGCTTCCAGTTGATCACATCCTGGCAGGCTCTTTCGAAACAGCCATGCGG
CTCCTTCATGACCAAGTAGGGGTAATCCAGTTTGGCCCCTACAAGCAACTGTTCCTACAGACATACGCCCGAGGCCGCACAACCTATCAG
GCTCTGCCCTGCCTACCCTCCATGTATGGCTATCCTAATCGCAACTGGAAGGATGCAGGGCTGAAGAATGGTGTACCAGCTGTGGGCCTG
AAGCTTAATGACCTCATCCAACGGTTGCAGCTGTGCTACCAGCTCACCACAGTTGGCAAATTTGAGGAGGCTGTGGAAAAATTCCGTTCC
ATCCTTCTCAGTGTGCCACTTCTTGTTGTGGACAATAAACAAGAGATTGCAGAGGCCCAGCAGCTCATCACCATTTGCCGTGAGTACATT
GTGGGTTTGTCCGTGGAGACAGAAAGGAAGAAGCTGCCCAAAGAGACTCTAGAACAGCAGAAGCGCATCTGTGAGATGGCAGCCTATTTC
ACCCACTCAAACCTGCAGCCTGTGCACATGATCCTGGTGCTGCGTACAGCCCTCAATCTGTTCTTCAAGCTCAAGAACTTCAAGACAGCT
GCCACCTTTGCTCGGCGCCTACTAGAACTCGGGCCCAAGCCTGAGGTGGCCCAACAGACCCGAAAAATCCTGTCTGCCTGTGAGAAGAAT
CCCACAGATGCCTACCAGCTCAATTATGACATGCACAACCCCTTTGACATTTGTGCTGCATCATATCGGCCCATCTACCGTGGAAAGCCA
GTAGAAAAGTGTCCACTCAGTGGGGCCTGCTATTCCCCTGAGTTCAAAGGTCAAATCTGCAGGGTCACCACAGTGACAGAGATTGGCAAA
GATGTGATTGGTTTAAGGATCAGTCCTCTGCAGTTTCGCTAAGGCCCCCTTTGTGTGCATGGGTCAGTCACCATATGTTCCCCCCAGAGA
ATGTGTCTATATCCTCCTTCTAACAGCACCTTCCCCCTGCAGCTACTCTTCAGATCTGGCTCTCTGTACCCTAAAACCTAGTATCTTTTT
CTCTTCTATGGAAAATCCGAAGGTCTAAACTTGACTTTTTTGAGGTCTTCTCAACTTGACTACAGTTGTGCTCATAATTGTCCTTGCCTT
TCCAGCTTAATTATTTTAAGGAACAAATGAAAACTCTGGGCTGGGTGGAGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTACGG
TGGGCAGATCATCTGAGGCCAGGAGTTCGAGACCTGCCTGGCCAACATGGCAACACCCCGTCTCTAATAAAAATATAAAAATTAGCCTGG
CATGGTAGCATGCGCCTATAGTCCCAGCTGCTCAGGAGGCTGAGGCATGAGAATCGCTTGAACCTAGGAGGTGGAGGTTGCATTCAACTG
AGATCATACCACTTCATTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAGGAAAACTCTGTGATGGACATTTGTT
TAGTAAATCCCTTCAGTATTTATCCCTCCTTTCCCCACAGCAGCTTTCTTTCCTGTCAACTAGAAAGGAGCAGGATGTAATAAATACATT
TTGGTGTGACTAGGCCACACCAACTCTTAATCATCTCCCATTTTCCTTAGACATTTAAATTTCAAGGCAGGTACCCTCTGTGTACTCAGA
AATTTGAAGAAGTTATTTGGTTTTCCAAAATGCACACTGCGGGTTATTGATTTGTTCTTTACAACTATTGTTCTCATATTTCTCACACTA

>In-frame_ENST00000388985_ENST00000241704_TCGA-EJ-5518-01A_SMYD3_chr1_245927343_-_COPA_chr1_160305112_length(amino acids)=1543AA_start in transcript=0_stop in transcript=4631
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC
NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQD
KDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI
FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVL
TGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIV
SGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD
GGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDAD
SQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKV
KYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCL
DRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDK
NCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLT
AATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAEL
QLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMR
LLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRS
ILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTA
ATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVEKCPLSGACYSPEFKGQICRVTTVTEIGK

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Fusion Gene PPI Analysis for SMYD3-COPA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMYD3-COPA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMYD3-COPA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMYD3C0236733Amphetamine-Related Disorders1CTD_human
HgeneSMYD3C0236804Amphetamine Addiction1CTD_human
HgeneSMYD3C0236807Amphetamine Abuse1CTD_human
TgeneCOPAC4225334AUTOIMMUNE INTERSTITIAL LUNG, JOINT, AND KIDNEY DISEASE2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneCOPAC0003864Arthritis1CTD_human
TgeneCOPAC0004364Autoimmune Diseases1CTD_human
TgeneCOPAC0162323Polyarthritis1CTD_human
TgeneCOPAC0206061Pneumonia, Interstitial1CTD_human
TgeneCOPAC0206062Lung Diseases, Interstitial1CTD_human
TgeneCOPAC3860213Autoinflammatory disorder1GENOMICS_ENGLAND