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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMYD3-GPATCH2 (FusionGDB2 ID:83790)

Fusion Gene Summary for SMYD3-GPATCH2

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD3-GPATCH2
Fusion gene ID: 83790
HgeneTgene
Gene symbol

SMYD3

GPATCH2

Gene ID

64754

55105

Gene nameSET and MYND domain containing 3G-patch domain containing 2
SynonymsKMT3E|ZMYND1|ZNFN3A1|bA74P14.1CT110|GPATC2|PPP1R30|Pfa1
Cytomap

1q44

1q41

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1G patch domain-containing protein 2cancer/testis antigen 110protein phosphatase 1, regulatory subunit 30
Modification date2020032020200313
UniProtAcc.

Q9NWQ4

Ensembl transtripts involved in fusion geneENST00000541742, ENST00000490107, 
ENST00000388985, ENST00000366517, 
ENST00000403792, 
ENST00000366935, 
ENST00000489246, ENST00000366934, 
Fusion gene scores* DoF score22 X 13 X 10=28608 X 7 X 5=280
# samples 248
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD3 [Title/Abstract] AND GPATCH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSMYD3(246490503)-GPATCH2(217604707), # samples:1
Anticipated loss of major functional domain due to fusion event.SMYD3-GPATCH2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMYD3-GPATCH2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPATCH2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across SMYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GPATCH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-8122-01ASMYD3chr1

246490503

-GPATCH2chr1

217604707

-


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Fusion Gene ORF analysis for SMYD3-GPATCH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000541742ENST00000366935SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000541742ENST00000489246SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000541742ENST00000366934SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
In-frameENST00000490107ENST00000366935SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000490107ENST00000489246SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000490107ENST00000366934SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
In-frameENST00000388985ENST00000366935SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000388985ENST00000489246SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000388985ENST00000366934SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
intron-3CDSENST00000366517ENST00000366935SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
intron-intronENST00000366517ENST00000489246SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
intron-intronENST00000366517ENST00000366934SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
In-frameENST00000403792ENST00000366935SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000403792ENST00000489246SMYD3chr1

246490503

-GPATCH2chr1

217604707

-
5CDS-intronENST00000403792ENST00000366934SMYD3chr1

246490503

-GPATCH2chr1

217604707

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000490107SMYD3chr1246490503-ENST00000366935GPATCH2chr1217604707-494557116579187
ENST00000388985SMYD3chr1246490503-ENST00000366935GPATCH2chr1217604707-49055310539179
ENST00000403792SMYD3chr1246490503-ENST00000366935GPATCH2chr1217604707-500062650634194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490107ENST00000366935SMYD3chr1246490503-GPATCH2chr1217604707-0.0030800810.99692
ENST00000388985ENST00000366935SMYD3chr1246490503-GPATCH2chr1217604707-0.0031033730.9968966
ENST00000403792ENST00000366935SMYD3chr1246490503-GPATCH2chr1217604707-0.0031801980.99681973

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Fusion Genomic Features for SMYD3-GPATCH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMYD3-GPATCH2


check button Go to

FGviewer for the breakpoints of chr1:246490503-chr1:217604707

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GPATCH2

Q9NWQ4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246490503chr1:217604707ENST00000388985-51214_16177.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:217604707ENST00000490107-51214_16118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:217604707ENST00000541742-51214_16118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:217604707ENST00000388985-51249_87177.0429.0Zinc fingerMYND-type
HgeneSMYD3chr1:246490503chr1:217604707ENST00000490107-51249_87118.0370.0Zinc fingerMYND-type
HgeneSMYD3chr1:246490503chr1:217604707ENST00000541742-51249_87118.0370.0Zinc fingerMYND-type
TgeneGPATCH2chr1:246490503chr1:217604707ENST0000036693406467_5130377.0DomainG-patch
TgeneGPATCH2chr1:246490503chr1:217604707ENST00000366935810467_513455.3333333333333529.0DomainG-patch

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246490503chr1:217604707ENST00000388985-5124_240177.0429.0DomainSET
HgeneSMYD3chr1:246490503chr1:217604707ENST00000490107-5124_240118.0370.0DomainSET
HgeneSMYD3chr1:246490503chr1:217604707ENST00000541742-5124_240118.0370.0DomainSET
HgeneSMYD3chr1:246490503chr1:217604707ENST00000388985-512205_206177.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:217604707ENST00000490107-512205_206118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:217604707ENST00000541742-512205_206118.0370.0RegionS-adenosyl-L-methionine binding


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Fusion Gene Sequence for SMYD3-GPATCH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000490107_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(transcript)=4945nt_BP=571nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGATTTGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTT
CAGAATATGGGCTGGACGCCTGGGTCAGGCCTTGGACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGA
TTAGGACTTGGATTTCCTCTACCAAAAAGTACTTCCGCAACTACTACCCCCAATGCAGGAAAATCCGCCTAAGAAAAGCAAAGAAGAAAT
GTTTTACAGACTTTATTCACTATGTCCCATTGTTCTAAAATGATAACATGACTTCTGTTTTTGAAGCAAAAATCTACATTGCCTCAAACA
CATCACTCTAGCTTCCTTACTGCATACAGTCCTGCCATAGTGAGAGAAATGGGATTTCATCACAATTCATGGTGCTAAAATGAAAACCTC
TGCACTTTAATTTTTTTCAGTAATTTCCAGCTATTTCTAGGTATAAAGAGCAGCTCGTTTCTCTTATTTATTTTAGTCTCATGTGTCAAT
ACTTTCCGATGCTTTGCTTAATTCATGTATGTGTGCAGTGCTGCAATGCCCAGACAAACGTGAGCACACCCACCAGTTTCTAAAATGGAA
TAGACAGGAAAAGATTGTGTTTTATATCATCCCTATCTATTGTAACCCAAAAGACCTACCATCGCATCAGTGAAGTCCGAACACATCTTT
GTTTGAAAGGCTTGTCAATTTCATATTCCTTGAATTGGCTTCTTGGTGAGGATTTTCTGACAGAGTGATACCCATCAATTTTCTATCCTT
AGACAATGTAGTGTGAAGTTCACAGTTGACAAACAACAATTAATGTTTCCCTTGGATGTTTTGACAAAAATAAACCTCATCGTTGTTATC
ACCAGAGTGCCCTCTACCTTACTTTAATGCAGATTTTATAAATTTTACCTCATTTAGAACATAAAATAATTATTGAAAGAAAAATGTATT
TTTTAAATTCACCGTGATTGAACTGTAAATTCTATTAATCCAGATGTACTTCTACCTCTGTTTTCCCAAAGATTGATATTATTTTTAAGA
TCAACTCAAGTGTAGTAAACGGATTTAAAATTTTAATCATTGGAGTAATTTATTACAATATTGAATCAATTTACATGAAAAGTTAAATGG
CTCTCCCAGAACTCAGATTTCTGGCAATGACCCAACCCATTTAGAAGGTGAACAAAAGAAGTAAATGGTACTGATTTGCCCTTTCTAGGA
CCCAAGATGTTACTTTAAAACCTAGCAAAAGAGGTCGTTTGTATTACGTGCCTAGTATTGAGCTGTTTCTGAGTCATTTGCTTCATAGTA
TCAGAAATTCTAAATTGCTTTTAGTTTAGAAGATCTTTATTTATTATCTTCATTATTAACAACTTATTATGATGATGATTATTATCATTC
TATTTATAATGGCCTTTGCTGGTTGAGTAAAGACTGAGATAACACATGTGAATCACCTTTCTAATGGGTTTTTAAAATCTTGTCACTTTC
CAAAAGAGTTTTTTTGTTTCTTTTTTTTTTTTTTTTTTTTTGACAGAGTCTGCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCACTCTC
GGCTCACTGCAGCCTCCCCCTCCTGGGTTCAAGTGATTGTTCTGCCTCAGCCTCCCAAATAGCAGGGATTACAGGCACCCACGACCATAC
CCGGATAATTTTTGTATTTTTAGTATAGACGGAGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCAC
CTTGGCCTCCCAAAGAGCTGGGATTACAGGCATGAACCACAGCGCCCAGCCCCCAGAAGAGTTTTTAAAAGGTGTTAAAGGAGGTTTATG
CACGTAACAGACCTTTCTCAGGTGGTCCCCTAAAAAAAATCCTGCCAACTAGGGAGGGGAAGTCCAACCTGCTATTTGAAAGCCTTCACG
GTTTGCCAAATGTACATTTCTTGAGAATTATCTTCTTTCCCAGGGATATTGTACCTAGAGGACAGGTTGGTTAGGGAACTATGGACGACC
AGAAGAGATGTTCTTTTGAAGCATTCTTACTGGATAAAGTAACCCCATGGTATCATTACTTTCTACAAGTTTTTTACTTACAAATTTGCC
ATTTTTTTAACTGATATTTTCTAAATGCTCATTCTGTCTATGTAGCCGGGGGGAGATTATATACAAGTTTTAAAACTTCTTTGTGATAGT
GTATTGTGCTCTGGGGTCTATTCAAAATTTGGTGTTTGAGGTTTTGTTAATTTGATTGCCTGGAGATCTGCTAAAATCCTAGAATCTCAA
AAAGCCAAGTTTGAAGCCACTGAGAGCAAACAATGAGGTCATTGTTAGCCTGGTTCCACACTCCTGAGGACTTGGCTGTTCTTTTTCACC
TTATTATGTTCTAATGGAAGTAAAAACCCTCATAGTGAAGAAGAGCAGTATATACACCAGACTAGTGTATAGGAACTTCTTCATTAAATA
TTGCAGTCCTTATGAGTGCTCTTTATTGTTGCTGTTCTGGACAGGTACAAATCTTCTGAAGCAACTTCTGTGGGATGTTAACTTAGCTTC
TCTAACACCTAAAAAAATTCTTCTTTGTATTTTCAGCTAATAGAAGACAGTTCTTCTTCATCTTGACACCTAGAGCCCTCTATGTGATTC
ACAGAGGACTTAAAATACTTCTTACTCTGTTGAAGTGTTTAATTGTACAGAATATATGTACTCTACAGTATATGTGAATCAGCACTCAAA
GCAGAGAAGTGATAACATCCCAAGCTTCCCCCATACTTCTACTGACATGCCCTCAGTCTTTAAGAAAACTCAGTACAGACCTGATGTTCT
GGTTGTACCTGAACTTAATTGGAGAAACAAACGCAATTAAAATACGAATTTTTTAGTGCAAATCAAATGTCTTTCACCATCTGAAGCCCA
CTAATTTGTCTTTTATATATAGTTAATTTTTTGCCAGTTACAACGTCCATAGAACCCCAAGATTTAGAATGTATCATTTATATTTCCTCT
AAAAGGTAGTAAGATATTTCTTCTGCTGTTTTGTGAAGCCACTCTTCTACAGTATCTGTAGCCTTATAGCAAATTAATTGGTTGTACTAA
AAATTTTAGAGACTGCATAGGTCTCCCTTTTCTATCCTAATTACCTGCAATAGCCTAGAGACGCTGAGCATGATTACATTAGCAACTTGA
CTGTTTAAAAAATTTGTTATACTTGATAATGACCAGACTGTGTGCTGGAGTCATTTGTTTCCTTCTTTTCTGCTCCCCGAATACACTATT
TAATTTGGTTACTTTTATTTTTAAACTATATGGCACCCTTTTAAATAAACATTCATTGCTAATTAAAATCTGCCAATAAATTGGTCTCAG
CATTTAAATACCATATATTTTATAACTCATACTGTGGCTATCAAACAGAAGTTAACACAGTAGGGGTAAAGATATACATAATGTGTACCT
ATAGGTGTATTTATAATGCCTGTGTGCAGTATACAGACATAATTACAAAATACTGCATTTTATTAATGTTTATTTTAATATTGAGAATTG
GCATTCTTGTAAATTGAACTGACAATTGCTTCTATTCAGTACACTTTATTTTGAGCAGATATTTCCGAAAAGAGAAAAAATCACTGTTGA
CATGCTTTTTAAAACTGTTTTCACCTGTATTTTGTCTTTCAAAAAGAAAAGTGATCTAAGTTGGCATTGTAAAGAAATTGTTAGCAAAGA
ATATTTTTTTTTATTTTTTCTTTTGGTAGAAAGTCATGTTAATAGTACAACAAAGAATCAAAGAATAAAACATAATGTTTAAGAACATTA
TTTATAAGTAGTCATTGTCTTTGTGCTTTAAATGTTTCCCTTTTACCTTAGAGTTATTTTTTAAAAGTTGAAAGTACTTTAAAAATTGGT
TTAAATGAGTACCCATTGACAATTATCATTTAATAGTGCAGTTAAGTTCAGCGAAAAATTTCAATATCTCAAAAAAATTAGAGAAAAATA
TTGGTAAATGTATTTGATTCACAAATGTATTCATAGCCGATTGTGAGCTGCTCTACCACATTTTCCTGTTTTTATTGTTTCTGTGAAGCT
TGATTAGACTAACTTGCTTAAGGTCTCTTTCCCCTCAAGGATTCTGTGATTCTAATGTAACAAGGTACACACGCTCTCTCTGACCACTTA
AAGTATCAGAGTTCAAATCTGTTACAATCACTCCATTTCCTTTTGGAAAGTTGTGCCTCTCATAAAGCTGCTTGGACATTTTAAGTGTTT

>In-frame_ENST00000490107_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(amino acids)=187AA_start in transcript=16_stop in transcript=579
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPD
HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLF

--------------------------------------------------------------
>In-frame_ENST00000388985_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(transcript)=4905nt_BP=531nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGATTTGTAG
GTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTTCAGAATATGGGCTGGACGCCTGGGTCAGGCCTTGGACGAG
ATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGATTAGGACTTGGATTTCCTCTACCAAAAAGTACTTCCGCAA
CTACTACCCCCAATGCAGGAAAATCCGCCTAAGAAAAGCAAAGAAGAAATGTTTTACAGACTTTATTCACTATGTCCCATTGTTCTAAAA
TGATAACATGACTTCTGTTTTTGAAGCAAAAATCTACATTGCCTCAAACACATCACTCTAGCTTCCTTACTGCATACAGTCCTGCCATAG
TGAGAGAAATGGGATTTCATCACAATTCATGGTGCTAAAATGAAAACCTCTGCACTTTAATTTTTTTCAGTAATTTCCAGCTATTTCTAG
GTATAAAGAGCAGCTCGTTTCTCTTATTTATTTTAGTCTCATGTGTCAATACTTTCCGATGCTTTGCTTAATTCATGTATGTGTGCAGTG
CTGCAATGCCCAGACAAACGTGAGCACACCCACCAGTTTCTAAAATGGAATAGACAGGAAAAGATTGTGTTTTATATCATCCCTATCTAT
TGTAACCCAAAAGACCTACCATCGCATCAGTGAAGTCCGAACACATCTTTGTTTGAAAGGCTTGTCAATTTCATATTCCTTGAATTGGCT
TCTTGGTGAGGATTTTCTGACAGAGTGATACCCATCAATTTTCTATCCTTAGACAATGTAGTGTGAAGTTCACAGTTGACAAACAACAAT
TAATGTTTCCCTTGGATGTTTTGACAAAAATAAACCTCATCGTTGTTATCACCAGAGTGCCCTCTACCTTACTTTAATGCAGATTTTATA
AATTTTACCTCATTTAGAACATAAAATAATTATTGAAAGAAAAATGTATTTTTTAAATTCACCGTGATTGAACTGTAAATTCTATTAATC
CAGATGTACTTCTACCTCTGTTTTCCCAAAGATTGATATTATTTTTAAGATCAACTCAAGTGTAGTAAACGGATTTAAAATTTTAATCAT
TGGAGTAATTTATTACAATATTGAATCAATTTACATGAAAAGTTAAATGGCTCTCCCAGAACTCAGATTTCTGGCAATGACCCAACCCAT
TTAGAAGGTGAACAAAAGAAGTAAATGGTACTGATTTGCCCTTTCTAGGACCCAAGATGTTACTTTAAAACCTAGCAAAAGAGGTCGTTT
GTATTACGTGCCTAGTATTGAGCTGTTTCTGAGTCATTTGCTTCATAGTATCAGAAATTCTAAATTGCTTTTAGTTTAGAAGATCTTTAT
TTATTATCTTCATTATTAACAACTTATTATGATGATGATTATTATCATTCTATTTATAATGGCCTTTGCTGGTTGAGTAAAGACTGAGAT
AACACATGTGAATCACCTTTCTAATGGGTTTTTAAAATCTTGTCACTTTCCAAAAGAGTTTTTTTGTTTCTTTTTTTTTTTTTTTTTTTT
TGACAGAGTCTGCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCACTCTCGGCTCACTGCAGCCTCCCCCTCCTGGGTTCAAGTGATTGT
TCTGCCTCAGCCTCCCAAATAGCAGGGATTACAGGCACCCACGACCATACCCGGATAATTTTTGTATTTTTAGTATAGACGGAGTTTCAC
CATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTTGGCCTCCCAAAGAGCTGGGATTACAGGCATGAACCAC
AGCGCCCAGCCCCCAGAAGAGTTTTTAAAAGGTGTTAAAGGAGGTTTATGCACGTAACAGACCTTTCTCAGGTGGTCCCCTAAAAAAAAT
CCTGCCAACTAGGGAGGGGAAGTCCAACCTGCTATTTGAAAGCCTTCACGGTTTGCCAAATGTACATTTCTTGAGAATTATCTTCTTTCC
CAGGGATATTGTACCTAGAGGACAGGTTGGTTAGGGAACTATGGACGACCAGAAGAGATGTTCTTTTGAAGCATTCTTACTGGATAAAGT
AACCCCATGGTATCATTACTTTCTACAAGTTTTTTACTTACAAATTTGCCATTTTTTTAACTGATATTTTCTAAATGCTCATTCTGTCTA
TGTAGCCGGGGGGAGATTATATACAAGTTTTAAAACTTCTTTGTGATAGTGTATTGTGCTCTGGGGTCTATTCAAAATTTGGTGTTTGAG
GTTTTGTTAATTTGATTGCCTGGAGATCTGCTAAAATCCTAGAATCTCAAAAAGCCAAGTTTGAAGCCACTGAGAGCAAACAATGAGGTC
ATTGTTAGCCTGGTTCCACACTCCTGAGGACTTGGCTGTTCTTTTTCACCTTATTATGTTCTAATGGAAGTAAAAACCCTCATAGTGAAG
AAGAGCAGTATATACACCAGACTAGTGTATAGGAACTTCTTCATTAAATATTGCAGTCCTTATGAGTGCTCTTTATTGTTGCTGTTCTGG
ACAGGTACAAATCTTCTGAAGCAACTTCTGTGGGATGTTAACTTAGCTTCTCTAACACCTAAAAAAATTCTTCTTTGTATTTTCAGCTAA
TAGAAGACAGTTCTTCTTCATCTTGACACCTAGAGCCCTCTATGTGATTCACAGAGGACTTAAAATACTTCTTACTCTGTTGAAGTGTTT
AATTGTACAGAATATATGTACTCTACAGTATATGTGAATCAGCACTCAAAGCAGAGAAGTGATAACATCCCAAGCTTCCCCCATACTTCT
ACTGACATGCCCTCAGTCTTTAAGAAAACTCAGTACAGACCTGATGTTCTGGTTGTACCTGAACTTAATTGGAGAAACAAACGCAATTAA
AATACGAATTTTTTAGTGCAAATCAAATGTCTTTCACCATCTGAAGCCCACTAATTTGTCTTTTATATATAGTTAATTTTTTGCCAGTTA
CAACGTCCATAGAACCCCAAGATTTAGAATGTATCATTTATATTTCCTCTAAAAGGTAGTAAGATATTTCTTCTGCTGTTTTGTGAAGCC
ACTCTTCTACAGTATCTGTAGCCTTATAGCAAATTAATTGGTTGTACTAAAAATTTTAGAGACTGCATAGGTCTCCCTTTTCTATCCTAA
TTACCTGCAATAGCCTAGAGACGCTGAGCATGATTACATTAGCAACTTGACTGTTTAAAAAATTTGTTATACTTGATAATGACCAGACTG
TGTGCTGGAGTCATTTGTTTCCTTCTTTTCTGCTCCCCGAATACACTATTTAATTTGGTTACTTTTATTTTTAAACTATATGGCACCCTT
TTAAATAAACATTCATTGCTAATTAAAATCTGCCAATAAATTGGTCTCAGCATTTAAATACCATATATTTTATAACTCATACTGTGGCTA
TCAAACAGAAGTTAACACAGTAGGGGTAAAGATATACATAATGTGTACCTATAGGTGTATTTATAATGCCTGTGTGCAGTATACAGACAT
AATTACAAAATACTGCATTTTATTAATGTTTATTTTAATATTGAGAATTGGCATTCTTGTAAATTGAACTGACAATTGCTTCTATTCAGT
ACACTTTATTTTGAGCAGATATTTCCGAAAAGAGAAAAAATCACTGTTGACATGCTTTTTAAAACTGTTTTCACCTGTATTTTGTCTTTC
AAAAAGAAAAGTGATCTAAGTTGGCATTGTAAAGAAATTGTTAGCAAAGAATATTTTTTTTTATTTTTTCTTTTGGTAGAAAGTCATGTT
AATAGTACAACAAAGAATCAAAGAATAAAACATAATGTTTAAGAACATTATTTATAAGTAGTCATTGTCTTTGTGCTTTAAATGTTTCCC
TTTTACCTTAGAGTTATTTTTTAAAAGTTGAAAGTACTTTAAAAATTGGTTTAAATGAGTACCCATTGACAATTATCATTTAATAGTGCA
GTTAAGTTCAGCGAAAAATTTCAATATCTCAAAAAAATTAGAGAAAAATATTGGTAAATGTATTTGATTCACAAATGTATTCATAGCCGA
TTGTGAGCTGCTCTACCACATTTTCCTGTTTTTATTGTTTCTGTGAAGCTTGATTAGACTAACTTGCTTAAGGTCTCTTTCCCCTCAAGG
ATTCTGTGATTCTAATGTAACAAGGTACACACGCTCTCTCTGACCACTTAAAGTATCAGAGTTCAAATCTGTTACAATCACTCCATTTCC
TTTTGGAAAGTTGTGCCTCTCATAAAGCTGCTTGGACATTTTAAGTGTTTTGTAATATGCATTGAAGTGTTGAGTTTTGTTTGCTGTAAG

>In-frame_ENST00000388985_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(amino acids)=179AA_start in transcript=0_stop in transcript=539
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL

--------------------------------------------------------------
>In-frame_ENST00000403792_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(transcript)=5000nt_BP=626nt
GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG
GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC
TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC
TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAAT
GCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAG
AATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAA
TGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGATT
TGTAGGTGAAAATGCCCAGCCAATCCTAGAAAATAATATTGGAAACCGAATGCTTCAGAATATGGGCTGGACGCCTGGGTCAGGCCTTGG
ACGAGATGGCAAGGGGATCTCTGAGCCAATTCAAGCCATGCAGAGGCCAAAGGGATTAGGACTTGGATTTCCTCTACCAAAAAGTACTTC
CGCAACTACTACCCCCAATGCAGGAAAATCCGCCTAAGAAAAGCAAAGAAGAAATGTTTTACAGACTTTATTCACTATGTCCCATTGTTC
TAAAATGATAACATGACTTCTGTTTTTGAAGCAAAAATCTACATTGCCTCAAACACATCACTCTAGCTTCCTTACTGCATACAGTCCTGC
CATAGTGAGAGAAATGGGATTTCATCACAATTCATGGTGCTAAAATGAAAACCTCTGCACTTTAATTTTTTTCAGTAATTTCCAGCTATT
TCTAGGTATAAAGAGCAGCTCGTTTCTCTTATTTATTTTAGTCTCATGTGTCAATACTTTCCGATGCTTTGCTTAATTCATGTATGTGTG
CAGTGCTGCAATGCCCAGACAAACGTGAGCACACCCACCAGTTTCTAAAATGGAATAGACAGGAAAAGATTGTGTTTTATATCATCCCTA
TCTATTGTAACCCAAAAGACCTACCATCGCATCAGTGAAGTCCGAACACATCTTTGTTTGAAAGGCTTGTCAATTTCATATTCCTTGAAT
TGGCTTCTTGGTGAGGATTTTCTGACAGAGTGATACCCATCAATTTTCTATCCTTAGACAATGTAGTGTGAAGTTCACAGTTGACAAACA
ACAATTAATGTTTCCCTTGGATGTTTTGACAAAAATAAACCTCATCGTTGTTATCACCAGAGTGCCCTCTACCTTACTTTAATGCAGATT
TTATAAATTTTACCTCATTTAGAACATAAAATAATTATTGAAAGAAAAATGTATTTTTTAAATTCACCGTGATTGAACTGTAAATTCTAT
TAATCCAGATGTACTTCTACCTCTGTTTTCCCAAAGATTGATATTATTTTTAAGATCAACTCAAGTGTAGTAAACGGATTTAAAATTTTA
ATCATTGGAGTAATTTATTACAATATTGAATCAATTTACATGAAAAGTTAAATGGCTCTCCCAGAACTCAGATTTCTGGCAATGACCCAA
CCCATTTAGAAGGTGAACAAAAGAAGTAAATGGTACTGATTTGCCCTTTCTAGGACCCAAGATGTTACTTTAAAACCTAGCAAAAGAGGT
CGTTTGTATTACGTGCCTAGTATTGAGCTGTTTCTGAGTCATTTGCTTCATAGTATCAGAAATTCTAAATTGCTTTTAGTTTAGAAGATC
TTTATTTATTATCTTCATTATTAACAACTTATTATGATGATGATTATTATCATTCTATTTATAATGGCCTTTGCTGGTTGAGTAAAGACT
GAGATAACACATGTGAATCACCTTTCTAATGGGTTTTTAAAATCTTGTCACTTTCCAAAAGAGTTTTTTTGTTTCTTTTTTTTTTTTTTT
TTTTTTGACAGAGTCTGCCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCACTCTCGGCTCACTGCAGCCTCCCCCTCCTGGGTTCAAGTG
ATTGTTCTGCCTCAGCCTCCCAAATAGCAGGGATTACAGGCACCCACGACCATACCCGGATAATTTTTGTATTTTTAGTATAGACGGAGT
TTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAGTGATCCGCCCACCTTGGCCTCCCAAAGAGCTGGGATTACAGGCATGA
ACCACAGCGCCCAGCCCCCAGAAGAGTTTTTAAAAGGTGTTAAAGGAGGTTTATGCACGTAACAGACCTTTCTCAGGTGGTCCCCTAAAA
AAAATCCTGCCAACTAGGGAGGGGAAGTCCAACCTGCTATTTGAAAGCCTTCACGGTTTGCCAAATGTACATTTCTTGAGAATTATCTTC
TTTCCCAGGGATATTGTACCTAGAGGACAGGTTGGTTAGGGAACTATGGACGACCAGAAGAGATGTTCTTTTGAAGCATTCTTACTGGAT
AAAGTAACCCCATGGTATCATTACTTTCTACAAGTTTTTTACTTACAAATTTGCCATTTTTTTAACTGATATTTTCTAAATGCTCATTCT
GTCTATGTAGCCGGGGGGAGATTATATACAAGTTTTAAAACTTCTTTGTGATAGTGTATTGTGCTCTGGGGTCTATTCAAAATTTGGTGT
TTGAGGTTTTGTTAATTTGATTGCCTGGAGATCTGCTAAAATCCTAGAATCTCAAAAAGCCAAGTTTGAAGCCACTGAGAGCAAACAATG
AGGTCATTGTTAGCCTGGTTCCACACTCCTGAGGACTTGGCTGTTCTTTTTCACCTTATTATGTTCTAATGGAAGTAAAAACCCTCATAG
TGAAGAAGAGCAGTATATACACCAGACTAGTGTATAGGAACTTCTTCATTAAATATTGCAGTCCTTATGAGTGCTCTTTATTGTTGCTGT
TCTGGACAGGTACAAATCTTCTGAAGCAACTTCTGTGGGATGTTAACTTAGCTTCTCTAACACCTAAAAAAATTCTTCTTTGTATTTTCA
GCTAATAGAAGACAGTTCTTCTTCATCTTGACACCTAGAGCCCTCTATGTGATTCACAGAGGACTTAAAATACTTCTTACTCTGTTGAAG
TGTTTAATTGTACAGAATATATGTACTCTACAGTATATGTGAATCAGCACTCAAAGCAGAGAAGTGATAACATCCCAAGCTTCCCCCATA
CTTCTACTGACATGCCCTCAGTCTTTAAGAAAACTCAGTACAGACCTGATGTTCTGGTTGTACCTGAACTTAATTGGAGAAACAAACGCA
ATTAAAATACGAATTTTTTAGTGCAAATCAAATGTCTTTCACCATCTGAAGCCCACTAATTTGTCTTTTATATATAGTTAATTTTTTGCC
AGTTACAACGTCCATAGAACCCCAAGATTTAGAATGTATCATTTATATTTCCTCTAAAAGGTAGTAAGATATTTCTTCTGCTGTTTTGTG
AAGCCACTCTTCTACAGTATCTGTAGCCTTATAGCAAATTAATTGGTTGTACTAAAAATTTTAGAGACTGCATAGGTCTCCCTTTTCTAT
CCTAATTACCTGCAATAGCCTAGAGACGCTGAGCATGATTACATTAGCAACTTGACTGTTTAAAAAATTTGTTATACTTGATAATGACCA
GACTGTGTGCTGGAGTCATTTGTTTCCTTCTTTTCTGCTCCCCGAATACACTATTTAATTTGGTTACTTTTATTTTTAAACTATATGGCA
CCCTTTTAAATAAACATTCATTGCTAATTAAAATCTGCCAATAAATTGGTCTCAGCATTTAAATACCATATATTTTATAACTCATACTGT
GGCTATCAAACAGAAGTTAACACAGTAGGGGTAAAGATATACATAATGTGTACCTATAGGTGTATTTATAATGCCTGTGTGCAGTATACA
GACATAATTACAAAATACTGCATTTTATTAATGTTTATTTTAATATTGAGAATTGGCATTCTTGTAAATTGAACTGACAATTGCTTCTAT
TCAGTACACTTTATTTTGAGCAGATATTTCCGAAAAGAGAAAAAATCACTGTTGACATGCTTTTTAAAACTGTTTTCACCTGTATTTTGT
CTTTCAAAAAGAAAAGTGATCTAAGTTGGCATTGTAAAGAAATTGTTAGCAAAGAATATTTTTTTTTATTTTTTCTTTTGGTAGAAAGTC
ATGTTAATAGTACAACAAAGAATCAAAGAATAAAACATAATGTTTAAGAACATTATTTATAAGTAGTCATTGTCTTTGTGCTTTAAATGT
TTCCCTTTTACCTTAGAGTTATTTTTTAAAAGTTGAAAGTACTTTAAAAATTGGTTTAAATGAGTACCCATTGACAATTATCATTTAATA
GTGCAGTTAAGTTCAGCGAAAAATTTCAATATCTCAAAAAAATTAGAGAAAAATATTGGTAAATGTATTTGATTCACAAATGTATTCATA
GCCGATTGTGAGCTGCTCTACCACATTTTCCTGTTTTTATTGTTTCTGTGAAGCTTGATTAGACTAACTTGCTTAAGGTCTCTTTCCCCT
CAAGGATTCTGTGATTCTAATGTAACAAGGTACACACGCTCTCTCTGACCACTTAAAGTATCAGAGTTCAAATCTGTTACAATCACTCCA
TTTCCTTTTGGAAAGTTGTGCCTCTCATAAAGCTGCTTGGACATTTTAAGTGTTTTGTAATATGCATTGAAGTGTTGAGTTTTGTTTGCT

>In-frame_ENST00000403792_ENST00000366935_TCGA-EQ-8122-01A_SMYD3_chr1_246490503_-_GPATCH2_chr1_217604707_length(amino acids)=194AA_start in transcript=50_stop in transcript=634
MLDAGSRLRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKC
QKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMYD3-GPATCH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMYD3-GPATCH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMYD3-GPATCH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMYD3C0236733Amphetamine-Related Disorders1CTD_human
HgeneSMYD3C0236804Amphetamine Addiction1CTD_human
HgeneSMYD3C0236807Amphetamine Abuse1CTD_human