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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SMYD3-ZMYM4 (FusionGDB2 ID:83804)

Fusion Gene Summary for SMYD3-ZMYM4

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD3-ZMYM4
Fusion gene ID: 83804
HgeneTgene
Gene symbol

SMYD3

ZMYM4

Gene ID

64754

9202

Gene nameSET and MYND domain containing 3zinc finger MYM-type containing 4
SynonymsKMT3E|ZMYND1|ZNFN3A1|bA74P14.1CDIR|MYM|ZNF198L3|ZNF262
Cytomap

1q44

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1zinc finger MYM-type protein 4cell death inhibiting RNAzinc finger protein 262zinc finger, MYM-type 4
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000541742, ENST00000490107, 
ENST00000388985, ENST00000366517, 
ENST00000403792, 		ENST00000373297, 
ENST00000314607, ENST00000482131, 
Fusion gene scores* DoF score22 X 13 X 10=286013 X 13 X 7=1183
# samples 2414
** MAII scorelog2(24/2860*10)=-3.57490883605723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1183*10)=-3.07895134139482
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD3 [Title/Abstract] AND ZMYM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYM4(35827390)-SMYD3(246093239), # samples:3
SMYD3(246490503)-ZMYM4(35835630), # samples:3
Anticipated loss of major functional domain due to fusion event.SMYD3-ZMYM4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SMYD3-ZMYM4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SMYD3-ZMYM4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SMYD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ZMYM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-DA-A1I7-06ASMYD3chr1

246490503

-ZMYM4chr1

35835630

+
ChimerDB4SKCMTCGA-DA-A1I7-06ASMYD3chr1

246490503

-ZMYM4chr1

35835630

+
ChimerDB4SKCMTCGA-DA-A1I7-06ASMYD3chr1

246490503

-ZMYM4chr1

35835630

+


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Fusion Gene ORF analysis for SMYD3-ZMYM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000541742ENST00000373297SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
Frame-shiftENST00000541742ENST00000314607SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
5CDS-3UTRENST00000541742ENST00000482131SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000490107ENST00000373297SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000490107ENST00000314607SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
5CDS-3UTRENST00000490107ENST00000482131SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000388985ENST00000373297SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000388985ENST00000314607SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
5CDS-3UTRENST00000388985ENST00000482131SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
intron-3CDSENST00000366517ENST00000373297SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
intron-3CDSENST00000366517ENST00000314607SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
intron-3UTRENST00000366517ENST00000482131SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000403792ENST00000373297SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
In-frameENST00000403792ENST00000314607SMYD3chr1

246490503

-ZMYM4chr1

35835630

+
5CDS-3UTRENST00000403792ENST00000482131SMYD3chr1

246490503

-ZMYM4chr1

35835630

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000490107SMYD3chr1246490503-ENST00000373297ZMYM4chr135835630+63775711641101364
ENST00000490107SMYD3chr1246490503-ENST00000314607ZMYM4chr135835630+66455711643771453
ENST00000388985SMYD3chr1246490503-ENST00000373297ZMYM4chr135835630+6337531040701356
ENST00000388985SMYD3chr1246490503-ENST00000314607ZMYM4chr135835630+6605531043371445
ENST00000403792SMYD3chr1246490503-ENST00000373297ZMYM4chr135835630+64326265041651371
ENST00000403792SMYD3chr1246490503-ENST00000314607ZMYM4chr135835630+67006265044321460

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000490107ENST00000373297SMYD3chr1246490503-ZMYM4chr135835630+8.21E-050.99991786
ENST00000490107ENST00000314607SMYD3chr1246490503-ZMYM4chr135835630+6.26E-050.9999373
ENST00000388985ENST00000373297SMYD3chr1246490503-ZMYM4chr135835630+7.77E-050.9999223
ENST00000388985ENST00000314607SMYD3chr1246490503-ZMYM4chr135835630+5.95E-050.9999405
ENST00000403792ENST00000373297SMYD3chr1246490503-ZMYM4chr135835630+8.77E-050.99991226
ENST00000403792ENST00000314607SMYD3chr1246490503-ZMYM4chr135835630+6.67E-050.99993324

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Fusion Genomic Features for SMYD3-ZMYM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SMYD3chr1246490502-ZMYM4chr135835629+4.41E-101
SMYD3chr1246490502-ZMYM4chr135835629+4.41E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SMYD3-ZMYM4


check button Go to

FGviewer for the breakpoints of chr1:246490503-chr1:35835630

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246490503chr1:35835630ENST00000388985-51214_16177.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:35835630ENST00000490107-51214_16118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:35835630ENST00000541742-51214_16118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:35835630ENST00000388985-51249_87177.0429.0Zinc fingerMYND-type
HgeneSMYD3chr1:246490503chr1:35835630ENST00000490107-51249_87118.0370.0Zinc fingerMYND-type
HgeneSMYD3chr1:246490503chr1:35835630ENST00000541742-51249_87118.0370.0Zinc fingerMYND-type
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430362_402280.01549.0Zinc fingerNote=MYM-type 1
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430414_457280.01549.0Zinc fingerNote=MYM-type 2
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430464_499280.01549.0Zinc fingerNote=MYM-type 3
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430510_544280.01549.0Zinc fingerNote=MYM-type 4
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430554_592280.01549.0Zinc fingerNote=MYM-type 5
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430600_631280.01549.0Zinc fingerNote=MYM-type 6
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430708_742280.01549.0Zinc fingerNote=MYM-type 7
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430749_788280.01549.0Zinc fingerNote=MYM-type 8
TgeneZMYM4chr1:246490503chr1:35835630ENST00000314607430795_829280.01549.0Zinc fingerNote=MYM-type 9
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428362_402280.01460.0Zinc fingerNote=MYM-type 1
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428414_457280.01460.0Zinc fingerNote=MYM-type 2
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428464_499280.01460.0Zinc fingerNote=MYM-type 3
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428510_544280.01460.0Zinc fingerNote=MYM-type 4
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428554_592280.01460.0Zinc fingerNote=MYM-type 5
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428600_631280.01460.0Zinc fingerNote=MYM-type 6
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428708_742280.01460.0Zinc fingerNote=MYM-type 7
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428749_788280.01460.0Zinc fingerNote=MYM-type 8
TgeneZMYM4chr1:246490503chr1:35835630ENST00000373297428795_829280.01460.0Zinc fingerNote=MYM-type 9

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMYD3chr1:246490503chr1:35835630ENST00000388985-5124_240177.0429.0DomainSET
HgeneSMYD3chr1:246490503chr1:35835630ENST00000490107-5124_240118.0370.0DomainSET
HgeneSMYD3chr1:246490503chr1:35835630ENST00000541742-5124_240118.0370.0DomainSET
HgeneSMYD3chr1:246490503chr1:35835630ENST00000388985-512205_206177.0429.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:35835630ENST00000490107-512205_206118.0370.0RegionS-adenosyl-L-methionine binding
HgeneSMYD3chr1:246490503chr1:35835630ENST00000541742-512205_206118.0370.0RegionS-adenosyl-L-methionine binding


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Fusion Gene Sequence for SMYD3-ZMYM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000490107_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6377nt_BP=571nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGT
GTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCC
TTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTC
TACTCAGCTATTCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTC
AAGTTGCTCAAAAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTC
ATGTTTGTCAACATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAA
TGCTGTTATTCGACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAA
CCTCACCATGAACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAA
GAAGTTTTGTAGTTCATCGTGTATCACGGCATACAAGCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTC
TCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAG
TAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACA
CTGTAACCGTCTTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATA
TAAGAAAATAAATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAA
GTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTT
ACAGACATCTCCCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTT
GTTCTATCAGATGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTG
TAACCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCA
AGCTGCTTCAGCAGGACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCA
GCCTACAGTGAATTCTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGC
CCTGAAACTGCCACCTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTG
CAAACCACATACCCAAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTT
TGTTCCCATACCTCTTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATC
TTCAATGGATAGTGAAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGA
GATGGCAGAAATGATTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACAC
CAAGATATTTGAAAAAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCT
GAATCACTATGCCTTAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGA
AGCAGATTTTCCATCAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGG
CTTCCCCCAACCCAGACGAAGAGGACGGAAGAAGTCTATAGTGGCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTC
AGTGTCCGGGATGACACTGAAATACATGTATGGGGTAAATGCTTGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGA
TCTAAAATGTGGAGGGGTTGAACAGGCCTCATCTAGCCCACGTTCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATC
CTCAGAGCCAGGCTGTAGAGTCCGCTCTATCAAGCTGAAGGAAGACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCA
GTTTATCCAAGAGGTGCGGAGACCAAATGGTGAAAAATATGATCCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTT
TGAAAATGGTAGAATAGATAACATTTTTACTGAGCCCTATTCCAGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTAC
AATACTTCCTAATGGTTACATGTTCTCTCGCATTGAGGAAGAGCATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCT
TTTAAACACCCTCCTTTTCTTCAATACCAAATACTTCCAACTAAAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAG
ACGGACCAGGACTCTGAAGTACAGTACCAAGATGACATATCTGAGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACT
GACTGTTGGCAAGAGGAAACGAAATGAAGATGATGAGGTTCCAGTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCC
AGTCCGACTTTATGAGTTTTACCTGTCAAAATGTTCTGAAAGTGTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTG
TGTCCCGAATAGCCCCATGTGGTACTCCACATTCCCGATAGACCCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGA
GGTACATGAAGAACTTGCCAAAGCCAAATCTGAAGACTCTGATGTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACA
TATTGGTATGCACCAAACTGTGAATGCATCCAGCTGTTGGAAAATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGA
AAACAGATGACTTGTGAACCCCACAGTGTGGATGTGCAAATGAAAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGAT
ATAGTTCTTAGACATCTTCAGAATGACTAATTTCTCCGAGTGGTGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTT
AAGGAAAACTGTTGTATAAAACTTTACCATAGTAACCTTAGACCTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACT
TTGGCAAGCCCTCCGTAAAAGTCAGAGGAGAGATCAGTACAGAGCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGAC
CCAATAAAAATACTCAACTTTTTAAAAAAGATAGTGAAGTGGTCTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACA
GAAGCTTTTGCCATGGGCCCCTCACATCAGGGAAAATGACCTTCACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCC
TTCTCAGCGGTGGGTCTGGATGTGGGTAAACTAAGGTAAAGGGGATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCC
TATCAGACCCCAAGTGTCTTGAAATGTTTGTAGAAACCCACTAAAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAG
CCTGAGCTGTGGTACAGAGAAATGGGGGTTCTCCTTTTATTTTCATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCC
TATTTCCCAAACAGTTCCTCTTATTTTGTCTTTTGCACCAGTTTCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTC
TGGCAAACCTGTGAGTGATTCCACAAAGATACAGTATTACTTAGCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAA
AGCATTTGGAAGATGACCTTGTTGCCCTTGAAACTTGAAAATAGGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAA
GCAGGTCTTAGAGCATTATTCCAAACTCTAGCTGTTTCAGTAGTTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCAT
CTCCCTCATCTCCATTCTCAGTTTCTTCCCCACAAAATTTGGAATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAA
GGTTAATTTGACGCTATGATAAAACTGAGAGATGTCAAAAAGCCTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTT
TTAGGTGGGGGTGGCAGGTGTATTTCTTTTTTAACAAATAAAAGGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTG
TGTACTTGGTGGTTCTGTCCCTCTGCCTGTAACAAATCTCATTTTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTG
TATGATTAATTCCATCTGTGTTTGTCATTTCTGACTGGAAAACTTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTG
TCTGATAAGTCTGCCAATAAACTATCCAGAAATAGCAAGTGTAATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATT
TTCCCCTTCTGTAGTTGTATGAAAAAACAAATATTGTTAGCATAGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTT
TACTGAGAACACCCAATACCCAGATAAATGACTGTATCAGGATTTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTAT
TCATAAGAGAAAATATTGATTAATTATTGGTCATTCCTCATAAGTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTAT
GAAAATTGTGTAAAATTACATTTTTTTTCCAGGGGAGAAAAAAACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTT

>In-frame_ENST00000490107_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1364AA_start in transcript=16_stop in transcript=4110
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPD
HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLF
EAFAKEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFC
STLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRH
EVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVPLSQGQVI
VSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINN
VMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMA
KCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNS
NSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPL
HLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEK
DQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPR
RRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGC
RVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNG
YMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKR
KRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEEL

--------------------------------------------------------------
>In-frame_ENST00000490107_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6645nt_BP=571nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGTATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGT
GTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGTTGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCC
TTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTTCTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTC
TACTCAGCTATTCTGCTCCACACTGTGCCTCACTGGATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTC
AAGTTGCTCAAAAGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTC
ATGTTTGTCAACATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAA
TGCTGTTATTCGACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAA
CCTCACCATGAACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAA
GAAGTTTTGTAGTTCATCGTGTATCACGGCATACAAGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTC
AGCAGAAATGATTGAAAATACCAATAGCTTGGGGAAGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGT
TACTTCTGCAGGTGTACAAGTTCAGTGTAACAGTTGTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACG
CAACTTCTGCAGCTACAGCTGTGTGGTAGCTTTCCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCA
GGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAG
CTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTG
TAACCGTCTTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAA
GAAAATAAATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTC
ATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACA
GACATCTCCCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTT
CTATCAGATGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAA
CCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGC
TGCTTCAGCAGGACCCCCATCTCTGAGAAAAGATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCC
TACAGTGAATTCTAACAGTGTCTTACAAGGTGCAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCT
GAAACTGCCACCTTCCCAACCTCCAAGGCTTTTGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAA
ACCACATACCCAAAACAAAGAATGCCAGACAGAAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGT
TCCCATACCTCTTCACCTTTATACTCAATATGCTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTC
AATGGATAGTGAAGATAAAGTCACAGAGAGTATTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGAT
GGCAGAAATGATTGCAGAAGATGAAGAGAAGAAGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAA
GATATTTGAAAAAGACCAAGGAAGTACATACAGTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAA
TCACTATGCCTTAAAGTCAAATGCTGTGCAAGAGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGC
AGATTTTCCATCAGACTCCTTTGACCCACTTAATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTT
CCCCCAACCCAGACGAAGAGGACGGAAGAAGTCTATAGTGGCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTCAGT
GTCCGGGATGACACTGAAATACATGTATGGGGTAAATGCTTGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGATCT
AAAATGTGGAGGGGTTGAACAGGCCTCATCTAGCCCACGTTCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATCCTC
AGAGCCAGGCTGTAGAGTCCGCTCTATCAAGCTGAAGGAAGACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCAGTT
TATCCAAGAGGTGCGGAGACCAAATGGTGAAAAATATGATCCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTTTGA
AAATGGTAGAATAGATAACATTTTTACTGAGCCCTATTCCAGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTACAAT
ACTTCCTAATGGTTACATGTTCTCTCGCATTGAGGAAGAGCATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCTTTT
AAACACCCTCCTTTTCTTCAATACCAAATACTTCCAACTAAAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAGACG
GACCAGGACTCTGAAGTACAGTACCAAGATGACATATCTGAGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACTGAC
TGTTGGCAAGAGGAAACGAAATGAAGATGATGAGGTTCCAGTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCCAGT
CCGACTTTATGAGTTTTACCTGTCAAAATGTTCTGAAAGTGTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTGTGT
CCCGAATAGCCCCATGTGGTACTCCACATTCCCGATAGACCCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGAGGT
ACATGAAGAACTTGCCAAAGCCAAATCTGAAGACTCTGATGTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACATAT
TGGTATGCACCAAACTGTGAATGCATCCAGCTGTTGGAAAATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGAAAA
CAGATGACTTGTGAACCCCACAGTGTGGATGTGCAAATGAAAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGATATA
GTTCTTAGACATCTTCAGAATGACTAATTTCTCCGAGTGGTGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTTAAG
GAAAACTGTTGTATAAAACTTTACCATAGTAACCTTAGACCTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACTTTG
GCAAGCCCTCCGTAAAAGTCAGAGGAGAGATCAGTACAGAGCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGACCCA
ATAAAAATACTCAACTTTTTAAAAAAGATAGTGAAGTGGTCTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACAGAA
GCTTTTGCCATGGGCCCCTCACATCAGGGAAAATGACCTTCACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCCTTC
TCAGCGGTGGGTCTGGATGTGGGTAAACTAAGGTAAAGGGGATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCCTAT
CAGACCCCAAGTGTCTTGAAATGTTTGTAGAAACCCACTAAAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAGCCT
GAGCTGTGGTACAGAGAAATGGGGGTTCTCCTTTTATTTTCATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCCTAT
TTCCCAAACAGTTCCTCTTATTTTGTCTTTTGCACCAGTTTCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTCTGG
CAAACCTGTGAGTGATTCCACAAAGATACAGTATTACTTAGCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAAAGC
ATTTGGAAGATGACCTTGTTGCCCTTGAAACTTGAAAATAGGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAAGCA
GGTCTTAGAGCATTATTCCAAACTCTAGCTGTTTCAGTAGTTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCATCTC
CCTCATCTCCATTCTCAGTTTCTTCCCCACAAAATTTGGAATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAAGGT
TAATTTGACGCTATGATAAAACTGAGAGATGTCAAAAAGCCTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTTTTA
GGTGGGGGTGGCAGGTGTATTTCTTTTTTAACAAATAAAAGGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTGTGT
ACTTGGTGGTTCTGTCCCTCTGCCTGTAACAAATCTCATTTTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTGTAT
GATTAATTCCATCTGTGTTTGTCATTTCTGACTGGAAAACTTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTGTCT
GATAAGTCTGCCAATAAACTATCCAGAAATAGCAAGTGTAATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATTTTC
CCCTTCTGTAGTTGTATGAAAAAACAAATATTGTTAGCATAGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTTTAC
TGAGAACACCCAATACCCAGATAAATGACTGTATCAGGATTTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTATTCA
TAAGAGAAAATATTGATTAATTATTGGTCATTCCTCATAAGTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTATGAA
AATTGTGTAAAATTACATTTTTTTTCCAGGGGAGAAAAAAACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTTTTT

>In-frame_ENST00000490107_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1453AA_start in transcript=16_stop in transcript=4377
MRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPD
HKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLF
EAFAKEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFC
STLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRH
EVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSSAEMIE
NTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIV
SIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNV
MAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAK
CDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSN
SVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLH
LYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKD
QGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRR
RGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCR
VRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGY
MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKRK
RNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELA

--------------------------------------------------------------
>In-frame_ENST00000388985_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6337nt_BP=531nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGTATAGT
CATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGTTGACT
ACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTTCTGGT
TGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTATTCTGCTCCACACTGTGCCTCACTGGATAT
ACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAAAAGACATTTTAAATCCAAAGGATGTGATC
AGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAACATATGAACTGAAAAAAAAACCTATTGTT
ACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTCGACATGAAGTTAATTACCAGAATGTGGTC
CATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGGGTTACTGT
TACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTAGTTCATCGTGTATCACGGCATACAAGCAG
AATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCACA
GTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCCAG
TCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTTTTGCCACAAAACCAGAACTTCTTGAC
TATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATAATGTAATGGCAATGTGTGAATATTGT
AAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAACAT
GACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCAAATTGGTACAGAATAATTTAGGAGGG
AAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGGCCAAATGTGATGCTTGTAAGCGACAG
GGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAAGT
GTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAGGACCCCCATCTCTGAGAAAAGATTCG
ACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATTCTAACAGTGTCTTACAAGGTGCAGTT
CCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCACCTTCCCAACCTCCAAGGCTTTTGAAG
AACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCCAAAACAAAGAATGCCAGACAGAAGAC
ACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTCTTCACCTTTATACTCAATATGCTCCA
GTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTGAAGATAAAGTCACAGAGAGTATTGAA
GACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGATTGCAGAAGATGAAGAGAAGAAGACT
CTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAAAAGACCAAGGAAGTACATACAGTGGT
GATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCTTAAAGTCAAATGCTGTGCAAGAGGCT
GATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCATCAGACTCCTTTGACCCACTTAATAAA
GGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCAGACGAAGAGGACGGAAGAAGTCTATA
GTGGCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTCAGTGTCCGGGATGACACTGAAATACATGTATGGGGTAAAT
GCTTGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGATCTAAAATGTGGAGGGGTTGAACAGGCCTCATCTAGCCCA
CGTTCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATCCTCAGAGCCAGGCTGTAGAGTCCGCTCTATCAAGCTGAAG
GAAGACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCAGTTTATCCAAGAGGTGCGGAGACCAAATGGTGAAAAATAT
GATCCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTTTGAAAATGGTAGAATAGATAACATTTTTACTGAGCCCTAT
TCCAGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTACAATACTTCCTAATGGTTACATGTTCTCTCGCATTGAGGAA
GAGCATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCTTTTAAACACCCTCCTTTTCTTCAATACCAAATACTTCCAA
CTAAAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAGACGGACCAGGACTCTGAAGTACAGTACCAAGATGACATAT
CTGAGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACTGACTGTTGGCAAGAGGAAACGAAATGAAGATGATGAGGTT
CCAGTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCCAGTCCGACTTTATGAGTTTTACCTGTCAAAATGTTCTGAA
AGTGTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTGTGTCCCGAATAGCCCCATGTGGTACTCCACATTCCCGATA
GACCCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGAGGTACATGAAGAACTTGCCAAAGCCAAATCTGAAGACTCT
GATGTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACATATTGGTATGCACCAAACTGTGAATGCATCCAGCTGTTGG
AAAATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGAAAACAGATGACTTGTGAACCCCACAGTGTGGATGTGCAAA
TGAAAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGATATAGTTCTTAGACATCTTCAGAATGACTAATTTCTCCGAG
TGGTGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTTAAGGAAAACTGTTGTATAAAACTTTACCATAGTAACCTTA
GACCTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACTTTGGCAAGCCCTCCGTAAAAGTCAGAGGAGAGATCAGTAC
AGAGCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGACCCAATAAAAATACTCAACTTTTTAAAAAAGATAGTGAAGT
GGTCTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACAGAAGCTTTTGCCATGGGCCCCTCACATCAGGGAAAATGAC
CTTCACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCCTTCTCAGCGGTGGGTCTGGATGTGGGTAAACTAAGGTAAA
GGGGATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCCTATCAGACCCCAAGTGTCTTGAAATGTTTGTAGAAACCCA
CTAAAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAGCCTGAGCTGTGGTACAGAGAAATGGGGGTTCTCCTTTTAT
TTTCATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCCTATTTCCCAAACAGTTCCTCTTATTTTGTCTTTTGCACCA
GTTTCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTCTGGCAAACCTGTGAGTGATTCCACAAAGATACAGTATTAC
TTAGCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAAAGCATTTGGAAGATGACCTTGTTGCCCTTGAAACTTGAAA
ATAGGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAAGCAGGTCTTAGAGCATTATTCCAAACTCTAGCTGTTTCAG
TAGTTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCATCTCCCTCATCTCCATTCTCAGTTTCTTCCCCACAAAATTT
GGAATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAAGGTTAATTTGACGCTATGATAAAACTGAGAGATGTCAAAA
AGCCTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTTTTAGGTGGGGGTGGCAGGTGTATTTCTTTTTTAACAAATA
AAAGGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTGTGTACTTGGTGGTTCTGTCCCTCTGCCTGTAACAAATCTC
ATTTTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTGTATGATTAATTCCATCTGTGTTTGTCATTTCTGACTGGAA
AACTTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTGTCTGATAAGTCTGCCAATAAACTATCCAGAAATAGCAAGT
GTAATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATTTTCCCCTTCTGTAGTTGTATGAAAAAACAAATATTGTTAG
CATAGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTTTACTGAGAACACCCAATACCCAGATAAATGACTGTATCAG
GATTTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTATTCATAAGAGAAAATATTGATTAATTATTGGTCATTCCTCA
TAAGTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTATGAAAATTGTGTAAAATTACATTTTTTTTCCAGGGGAGAAA
AAAACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTTTTTAACCACTTTTAGGTTTTCCCCTTACAGAAACCACAGA

>In-frame_ENST00000388985_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1356AA_start in transcript=0_stop in transcript=4070
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKEYS
HGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGY
TVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVV
HKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVPLSQGQVIVSIPTGST
VSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYC
KIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAKCDACKRQ
GKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAV
PTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAP
VPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGSTYSG
DLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSI
VAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCRVRSIKLK
EDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEE
EHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKRKRNEDDEV
PVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDS

--------------------------------------------------------------
>In-frame_ENST00000388985_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6605nt_BP=531nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGTATAGT
CATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGTTGACT
ACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTTCTGGT
TGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTATTCTGCTCCACACTGTGCCTCACTGGATAT
ACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAAAAGACATTTTAAATCCAAAGGATGTGATC
AGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAACATATGAACTGAAAAAAAAACCTATTGTT
ACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTCGACATGAAGTTAATTACCAGAATGTGGTC
CATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGGGTTACTGT
TACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTAGTTCATCGTGTATCACGGCATACAAGCAG
AAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGATTGAAAATACCAATAGCTTGGGGAAGACA
GAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAGGTGTACAAGTTCAGTGTAACAGTTGTAAA
ACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCAGCTACAGCTGTGTGGTAGCTTTCCAGAAT
TTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCACAGTG
TCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCC
CAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTTTTGCCACAAAACCAGAACTTCTTGACTAT
AAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATAATGTAATGGCAATGTGTGAATATTGTAAA
ATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAACATGAC
TTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCAAATTGGTACAGAATAATTTAGGAGGGAAA
GTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGGCCAAATGTGATGCTTGTAAGCGACAGGGT
AAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAAGTGTA
TGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAGGACCCCCATCTCTGAGAAAAGATTCGACT
CCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATTCTAACAGTGTCTTACAAGGTGCAGTTCCA
ACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCACCTTCCCAACCTCCAAGGCTTTTGAAGAAC
AAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCCAAAACAAAGAATGCCAGACAGAAGACACT
CCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTCTTCACCTTTATACTCAATATGCTCCAGTC
CCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTGAAGATAAAGTCACAGAGAGTATTGAAGAC
ATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGATTGCAGAAGATGAAGAGAAGAAGACTCTA
TCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAAAAGACCAAGGAAGTACATACAGTGGTGAT
CTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCTTAAAGTCAAATGCTGTGCAAGAGGCTGAT
TCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCATCAGACTCCTTTGACCCACTTAATAAAGGA
CAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCAGACGAAGAGGACGGAAGAAGTCTATAGTG
GCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTCAGTGTCCGGGATGACACTGAAATACATGTATGGGGTAAATGCT
TGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGATCTAAAATGTGGAGGGGTTGAACAGGCCTCATCTAGCCCACGT
TCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATCCTCAGAGCCAGGCTGTAGAGTCCGCTCTATCAAGCTGAAGGAA
GACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCAGTTTATCCAAGAGGTGCGGAGACCAAATGGTGAAAAATATGAT
CCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTTTGAAAATGGTAGAATAGATAACATTTTTACTGAGCCCTATTCC
AGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTACAATACTTCCTAATGGTTACATGTTCTCTCGCATTGAGGAAGAG
CATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCTTTTAAACACCCTCCTTTTCTTCAATACCAAATACTTCCAACTA
AAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAGACGGACCAGGACTCTGAAGTACAGTACCAAGATGACATATCTG
AGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACTGACTGTTGGCAAGAGGAAACGAAATGAAGATGATGAGGTTCCA
GTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCCAGTCCGACTTTATGAGTTTTACCTGTCAAAATGTTCTGAAAGT
GTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTGTGTCCCGAATAGCCCCATGTGGTACTCCACATTCCCGATAGAC
CCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGAGGTACATGAAGAACTTGCCAAAGCCAAATCTGAAGACTCTGAT
GTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACATATTGGTATGCACCAAACTGTGAATGCATCCAGCTGTTGGAAA
ATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGAAAACAGATGACTTGTGAACCCCACAGTGTGGATGTGCAAATGA
AAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGATATAGTTCTTAGACATCTTCAGAATGACTAATTTCTCCGAGTGG
TGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTTAAGGAAAACTGTTGTATAAAACTTTACCATAGTAACCTTAGAC
CTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACTTTGGCAAGCCCTCCGTAAAAGTCAGAGGAGAGATCAGTACAGA
GCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGACCCAATAAAAATACTCAACTTTTTAAAAAAGATAGTGAAGTGGT
CTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACAGAAGCTTTTGCCATGGGCCCCTCACATCAGGGAAAATGACCTT
CACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCCTTCTCAGCGGTGGGTCTGGATGTGGGTAAACTAAGGTAAAGGG
GATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCCTATCAGACCCCAAGTGTCTTGAAATGTTTGTAGAAACCCACTA
AAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAGCCTGAGCTGTGGTACAGAGAAATGGGGGTTCTCCTTTTATTTT
CATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCCTATTTCCCAAACAGTTCCTCTTATTTTGTCTTTTGCACCAGTT
TCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTCTGGCAAACCTGTGAGTGATTCCACAAAGATACAGTATTACTTA
GCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAAAGCATTTGGAAGATGACCTTGTTGCCCTTGAAACTTGAAAATA
GGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAAGCAGGTCTTAGAGCATTATTCCAAACTCTAGCTGTTTCAGTAG
TTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCATCTCCCTCATCTCCATTCTCAGTTTCTTCCCCACAAAATTTGGA
ATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAAGGTTAATTTGACGCTATGATAAAACTGAGAGATGTCAAAAAGC
CTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTTTTAGGTGGGGGTGGCAGGTGTATTTCTTTTTTAACAAATAAAA
GGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTGTGTACTTGGTGGTTCTGTCCCTCTGCCTGTAACAAATCTCATT
TTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTGTATGATTAATTCCATCTGTGTTTGTCATTTCTGACTGGAAAAC
TTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTGTCTGATAAGTCTGCCAATAAACTATCCAGAAATAGCAAGTGTA
ATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATTTTCCCCTTCTGTAGTTGTATGAAAAAACAAATATTGTTAGCAT
AGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTTTACTGAGAACACCCAATACCCAGATAAATGACTGTATCAGGAT
TTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTATTCATAAGAGAAAATATTGATTAATTATTGGTCATTCCTCATAA
GTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTATGAAAATTGTGTAAAATTACATTTTTTTTCCAGGGGAGAAAAAA
ACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTTTTTAACCACTTTTAGGTTTTCCCCTTACAGAAACCACAGAAAT

>In-frame_ENST00000388985_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1445AA_start in transcript=0_stop in transcript=4337
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKEYS
HGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGY
TVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVV
HKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLRSSAEMIENTNSLGKT
ELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPLSQGQVIVSIPTGSTV
SAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCK
IEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTVLFYQMAKCDACKRQG
KLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAVP
TVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPLHLYTQYAPV
PFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLDTKIFEKDQGSTYSGD
LESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRDGFPQPRRRGRKKSIV
AVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCRVRSIKLKE
DILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEPTILPNGYMFSRIEEE
HLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDKLTVGKRKRNEDDEVP
VGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVHEELAKAKSEDSD

--------------------------------------------------------------
>In-frame_ENST00000403792_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6432nt_BP=626nt
GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG
GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC
TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC
TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAAT
GCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAG
AATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAA
TGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGT
ATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGT
TGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTT
CTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTATTCTGCTCCACACTGTGCCTCACTG
GATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAAAAGACATTTTAAATCCAAAGGATG
TGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAACATATGAACTGAAAAAAAAACCTA
TTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTCGACATGAAGTTAATTACCAGAATG
TGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGGGTT
ACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTAGTTCATCGTGTATCACGGCATACA
AGCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTT
CCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTG
CCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTTTTGCCACAAAACCAGAACTTC
TTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATAATGTAATGGCAATGTGTGAAT
ATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATA
AACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCAAATTGGTACAGAATAATTTAG
GAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGGCCAAATGTGATGCTTGTAAGC
GACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTATCTTGATGTTCTGTAATCAGC
AAAGTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAGGACCCCCATCTCTGAGAAAAG
ATTCGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATTCTAACAGTGTCTTACAAGGTG
CAGTTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCACCTTCCCAACCTCCAAGGCTTT
TGAAGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCCAAAACAAAGAATGCCAGACAG
AAGACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTCTTCACCTTTATACTCAATATG
CTCCAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTGAAGATAAAGTCACAGAGAGTA
TTGAAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGATTGCAGAAGATGAAGAGAAGA
AGACTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAAAAGACCAAGGAAGTACATACA
GTGGTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCTTAAAGTCAAATGCTGTGCAAG
AGGCTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCATCAGACTCCTTTGACCCACTTA
ATAAAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCAGACGAAGAGGACGGAAGAAGT
CTATAGTGGCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTCAGTGTCCGGGATGACACTGAAATACATGTATGGGG
TAAATGCTTGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGATCTAAAATGTGGAGGGGTTGAACAGGCCTCATCTA
GCCCACGTTCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATCCTCAGAGCCAGGCTGTAGAGTCCGCTCTATCAAGC
TGAAGGAAGACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCAGTTTATCCAAGAGGTGCGGAGACCAAATGGTGAAA
AATATGATCCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTTTGAAAATGGTAGAATAGATAACATTTTTACTGAGC
CCTATTCCAGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTACAATACTTCCTAATGGTTACATGTTCTCTCGCATTG
AGGAAGAGCATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCTTTTAAACACCCTCCTTTTCTTCAATACCAAATACT
TCCAACTAAAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAGACGGACCAGGACTCTGAAGTACAGTACCAAGATGA
CATATCTGAGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACTGACTGTTGGCAAGAGGAAACGAAATGAAGATGATG
AGGTTCCAGTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCCAGTCCGACTTTATGAGTTTTACCTGTCAAAATGTT
CTGAAAGTGTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTGTGTCCCGAATAGCCCCATGTGGTACTCCACATTCC
CGATAGACCCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGAGGTACATGAAGAACTTGCCAAAGCCAAATCTGAAG
ACTCTGATGTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACATATTGGTATGCACCAAACTGTGAATGCATCCAGCT
GTTGGAAAATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGAAAACAGATGACTTGTGAACCCCACAGTGTGGATGT
GCAAATGAAAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGATATAGTTCTTAGACATCTTCAGAATGACTAATTTCT
CCGAGTGGTGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTTAAGGAAAACTGTTGTATAAAACTTTACCATAGTAA
CCTTAGACCTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACTTTGGCAAGCCCTCCGTAAAAGTCAGAGGAGAGATC
AGTACAGAGCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGACCCAATAAAAATACTCAACTTTTTAAAAAAGATAGT
GAAGTGGTCTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACAGAAGCTTTTGCCATGGGCCCCTCACATCAGGGAAA
ATGACCTTCACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCCTTCTCAGCGGTGGGTCTGGATGTGGGTAAACTAAG
GTAAAGGGGATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCCTATCAGACCCCAAGTGTCTTGAAATGTTTGTAGAA
ACCCACTAAAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAGCCTGAGCTGTGGTACAGAGAAATGGGGGTTCTCCT
TTTATTTTCATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCCTATTTCCCAAACAGTTCCTCTTATTTTGTCTTTTG
CACCAGTTTCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTCTGGCAAACCTGTGAGTGATTCCACAAAGATACAGT
ATTACTTAGCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAAAGCATTTGGAAGATGACCTTGTTGCCCTTGAAACT
TGAAAATAGGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAAGCAGGTCTTAGAGCATTATTCCAAACTCTAGCTGT
TTCAGTAGTTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCATCTCCCTCATCTCCATTCTCAGTTTCTTCCCCACAA
AATTTGGAATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAAGGTTAATTTGACGCTATGATAAAACTGAGAGATGT
CAAAAAGCCTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTTTTAGGTGGGGGTGGCAGGTGTATTTCTTTTTTAAC
AAATAAAAGGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTGTGTACTTGGTGGTTCTGTCCCTCTGCCTGTAACAA
ATCTCATTTTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTGTATGATTAATTCCATCTGTGTTTGTCATTTCTGAC
TGGAAAACTTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTGTCTGATAAGTCTGCCAATAAACTATCCAGAAATAG
CAAGTGTAATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATTTTCCCCTTCTGTAGTTGTATGAAAAAACAAATATT
GTTAGCATAGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTTTACTGAGAACACCCAATACCCAGATAAATGACTGT
ATCAGGATTTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTATTCATAAGAGAAAATATTGATTAATTATTGGTCATT
CCTCATAAGTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTATGAAAATTGTGTAAAATTACATTTTTTTTCCAGGGG
AGAAAAAAACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTTTTTAACCACTTTTAGGTTTTCCCCTTACAGAAACC

>In-frame_ENST00000403792_ENST00000373297_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1371AA_start in transcript=50_stop in transcript=4165
MLDAGSRLRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKC
QKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQL
PPAFDLFEAFAKEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRK
GSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQ
KNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQNLFNKPTGMNSSVVP
LSQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSD
EYKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYT
VLFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPA
AQPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVP
VFVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFL
DTKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHR
DGFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQ
ESSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWE
PTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPD
KLTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMV

--------------------------------------------------------------
>In-frame_ENST00000403792_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(transcript)=6700nt_BP=626nt
GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG
GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC
TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC
TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAAT
GCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAG
AATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAA
TGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGAGT
ATAGTCATGGCCAACAGCAAAAAACTCAAGAGGGGGAACTGAAAATTAGTGCTGTGTTTTCAGTCAGTGGCAGCCCTCTTGCTCCACAGT
TGACTACTGGCTTTCAGCCCTCACTGGCGTCATCTGGCATGAATAAAATGCTTCCTTCAGTTCCAGCCACAGCTGTTCGAGTTTCCTGTT
CTGGTTGTAAAAAAATCCTCCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGGTCTACTCAGCTATTCTGCTCCACACTGTGCCTCACTG
GATATACAGTTCCACCTGCCCGCCCACCGCCTCCTCTCACCAAGAAAACTTGTTCAAGTTGCTCAAAAGACATTTTAAATCCAAAGGATG
TGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAACATATGAACTGAAAAAAAAACCTA
TTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTCGACATGAAGTTAATTACCAGAATG
TGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGGGTT
ACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTAGTTCATCGTGTATCACGGCATACA
AGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGATTGAAAATACCAATAGCTTGGGGA
AGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAGGTGTACAAGTTCAGTGTAACAGTT
GTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCAGCTACAGCTGTGTGGTAGCTTTCC
AGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCA
CAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCC
AGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTTTTGCCACAAAACCAGAACTTCTTG
ACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATAATGTAATGGCAATGTGTGAATATT
GTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAAC
ATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCAAATTGGTACAGAATAATTTAGGAG
GGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGGCCAAATGTGATGCTTGTAAGCGAC
AGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAA
GTGTATGTGACCCGCCTTCACAAAATAATGCAGCAAATATTTCCATGGTTCAAGCTGCTTCAGCAGGACCCCCATCTCTGAGAAAAGATT
CGACTCCAGTTATAGCCAATGTAGTATCATTGGCAAGTGCCCCTGCTGCTCAGCCTACAGTGAATTCTAACAGTGTCTTACAAGGTGCAG
TTCCAACAGTAACAGCGAAAATCATCGGTGATGCAAGTACTCAAACAGATGCCCTGAAACTGCCACCTTCCCAACCTCCAAGGCTTTTGA
AGAACAAAGCTTTATTATGCAAACCCATCACACAGACTAAAGCCACCTCTTGCAAACCACATACCCAAAACAAAGAATGCCAGACAGAAG
ACACTCCAAGTCAGCCCCAGATTATTGTGGTGCCAGTTCCCGTACCAGTGTTTGTTCCCATACCTCTTCACCTTTATACTCAATATGCTC
CAGTCCCATTTGGAATTCCAGTTCCAATGCCTGTCCCTATGCTTATTCCATCTTCAATGGATAGTGAAGATAAAGTCACAGAGAGTATTG
AAGACATTAAAGAAAAGCTTCCCACACATCCATTTGAAGCTGATCTCCTTGAGATGGCAGAAATGATTGCAGAAGATGAAGAGAAGAAGA
CTCTATCTCAGGGAGAGTCCCAAACTTCTGAACACGAACTCTTTCTAGACACCAAGATATTTGAAAAAGACCAAGGAAGTACATACAGTG
GTGATCTTGAATCAGAGGCAGTATCTACTCCACATAGCTGGGAGGAAGAGCTGAATCACTATGCCTTAAAGTCAAATGCTGTGCAAGAGG
CTGATTCAGAATTGAAGCAGTTCTCAAAAGGGGAAACTGAACAGGACCTGGAAGCAGATTTTCCATCAGACTCCTTTGACCCACTTAATA
AAGGACAGGGAATCCAGGCACGTTCCCGAACAAGACGACGACACAGAGATGGCTTCCCCCAACCCAGACGAAGAGGACGGAAGAAGTCTA
TAGTGGCTGTGGAGCCCAGGAGTCTTATTCAAGGAGCCTTTCAAGGCTGCTCAGTGTCCGGGATGACACTGAAATACATGTATGGGGTAA
ATGCTTGGAAGAACTGGGTTCAGTGGAAAAATGCCAAGGAAGAGCAGGGGGATCTAAAATGTGGAGGGGTTGAACAGGCCTCATCTAGCC
CACGTTCTGACCCCTTAGGAAGTACTCAAGACCATGCACTCTCTCAAGAATCCTCAGAGCCAGGCTGTAGAGTCCGCTCTATCAAGCTGA
AGGAAGACATTCTGTCCTGCACTTTTGCTGAGTTGAGTTTGGGCTTATGCCAGTTTATCCAAGAGGTGCGGAGACCAAATGGTGAAAAAT
ATGATCCAGACAGTATCTTATACTTGTGCCTTGGAATTCAACAGTACCTGTTTGAAAATGGTAGAATAGATAACATTTTTACTGAGCCCT
ATTCCAGATTTATGATTGAACTTACCAAACTCTTGAAAATATGGGAACCTACAATACTTCCTAATGGTTACATGTTCTCTCGCATTGAGG
AAGAGCATTTGTGGGAGTGCAAACAGCTGGGCGCTTACTCACCAATCGTCCTTTTAAACACCCTCCTTTTCTTCAATACCAAATACTTCC
AACTAAAGAATGTTACTGAGCACTTGAAGCTTTCCTTTGCCCATGTGATGAGACGGACCAGGACTCTGAAGTACAGTACCAAGATGACAT
ATCTGAGGTTCTTCCCACCTTTACAGAAGCAGGAGTCAGAACCAGATAAACTGACTGTTGGCAAGAGGAAACGAAATGAAGATGATGAGG
TTCCAGTGGGGGTGGAGATGGCAGAGAATACTGACAATCCACTAAGATGCCCAGTCCGACTTTATGAGTTTTACCTGTCAAAATGTTCTG
AAAGTGTGAAGCAAAGGAATGATGTGTTTTACCTTCAACCTGAGCGCTCCTGTGTCCCGAATAGCCCCATGTGGTACTCCACATTCCCGA
TAGACCCTGGAACCCTGGACACCATGTTAACACGTATTCTCATGGTGAGGGAGGTACATGAAGAACTTGCCAAAGCCAAATCTGAAGACT
CTGATGTTGAATTATCAGATTAAAACGGAAGTGAGGTTCTTATTTTCATACATATTGGTATGCACCAAACTGTGAATGCATCCAGCTGTT
GGAAAATGATGTATAAGTCTAAGTCCTCTTGACTTGACCATAAGATCATGGAAAACAGATGACTTGTGAACCCCACAGTGTGGATGTGCA
AATGAAAATTGAAGGAAAGAATATGAACTGAGAAATGTTCTTTGGCAGTGATATAGTTCTTAGACATCTTCAGAATGACTAATTTCTCCG
AGTGGTGCATAATCTTATTTTGTTTGGGAGTAACAAATCGTGGAATATTTTTAAGGAAAACTGTTGTATAAAACTTTACCATAGTAACCT
TAGACCTTAGAGAGGTAGCTTTGGAGTGAAACTTTGGCTGCAATAGGCTACTTTGGCAAGCCCTCCGTAAAAGTCAGAGGAGAGATCAGT
ACAGAGCTAAGAGTGACATCAAATGAGGACTGTGGGACCCAGATTTGAAGACCCAATAAAAATACTCAACTTTTTAAAAAAGATAGTGAA
GTGGTCTTGATTGATTTTGATTTTCACTGCCAAGCCAATCATGTGAAGGACAGAAGCTTTTGCCATGGGCCCCTCACATCAGGGAAAATG
ACCTTCACTGCTGTTAACAGTAATGTGTCCCTTTCATTTTCTGGATCAAGCCTTCTCAGCGGTGGGTCTGGATGTGGGTAAACTAAGGTA
AAGGGGATGATATTCCACAAACTAATTATGCACACAGAAAATCTGTGGAGCCTATCAGACCCCAAGTGTCTTGAAATGTTTGTAGAAACC
CACTAAAATGCCCCTTCTCTGGGTGTGGGCCCTTATTGCAGCTGTCTCACAGCCTGAGCTGTGGTACAGAGAAATGGGGGTTCTCCTTTT
ATTTTCATTTTTTTTCCCCAATGGCAGCTTTTCTCCCGTTGTTTTACCTTCCTATTTCCCAAACAGTTCCTCTTATTTTGTCTTTTGCAC
CAGTTTCTGGAGGCCCTTGTCATTTCAAAAAGGATAGTCTCTTTTCTTACTCTGGCAAACCTGTGAGTGATTCCACAAAGATACAGTATT
ACTTAGCTATCTGAATTATGATAGAAAAGGTCCTAGTTAGGTTCCTATATAAAGCATTTGGAAGATGACCTTGTTGCCCTTGAAACTTGA
AAATAGGGATTCTGGGGTGAGGATACAAAGACATTGTCTTGCATATCCATAAGCAGGTCTTAGAGCATTATTCCAAACTCTAGCTGTTTC
AGTAGTTCTATGAGGATTGCAAGTCATAGGTGTGTGTGGCATATCAGTCCATCTCCCTCATCTCCATTCTCAGTTTCTTCCCCACAAAAT
TTGGAATCAAAGCTTTTATGACGTTTGCCAATTGCAGAACTTCTTCAGCTAAGGTTAATTTGACGCTATGATAAAACTGAGAGATGTCAA
AAAGCCTCTTAGAAATTTTAATCTTGAAAGACTTTTCAGGGTATCTCATTTTTTAGGTGGGGGTGGCAGGTGTATTTCTTTTTTAACAAA
TAAAAGGCATTTAAGTAAAACTAAAATGAAAAAAGTAGGCCTTCTGACATTGTGTACTTGGTGGTTCTGTCCCTCTGCCTGTAACAAATC
TCATTTTTGTTACCAAGAACTGTATGAAAGAAGTAAATCCACCCCGATTCTGTATGATTAATTCCATCTGTGTTTGTCATTTCTGACTGG
AAAACTTCTTACTCCATACCTTGTTCGATATGGAGGACAAATAATTGGATTGTCTGATAAGTCTGCCAATAAACTATCCAGAAATAGCAA
GTGTAATAGTCCCCACTATACGAATTTTATGGTTTGTATAAACACTAACATTTTCCCCTTCTGTAGTTGTATGAAAAAACAAATATTGTT
AGCATAGTAGATAAATTGTTATGAAATACCAGAAAAAAAAATCTGTATCTTTTACTGAGAACACCCAATACCCAGATAAATGACTGTATC
AGGATTTCATTTGCATGTTAGTCCACAGAGTTGCCCAGAACCCTAAATTTATTCATAAGAGAAAATATTGATTAATTATTGGTCATTCCT
CATAAGTGTAGCTGTTGATGTGTGCGTCTGATTATTGCTTTTTTAATTTTATGAAAATTGTGTAAAATTACATTTTTTTTCCAGGGGAGA
AAAAAACATCAAACAAAAACATCTAAATCATCCTTTTTGTTCTTTTTCAGTTTTTAACCACTTTTAGGTTTTCCCCTTACAGAAACCACA

>In-frame_ENST00000403792_ENST00000314607_TCGA-DA-A1I7-06A_SMYD3_chr1_246490503_-_ZMYM4_chr1_35835630_length(amino acids)=1460AA_start in transcript=50_stop in transcript=4432
MLDAGSRLRCRSCGRMEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKC
QKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQL
PPAFDLFEAFAKEYSHGQQQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNKMLPSVPATAVRVSCSGCKKILQKGQTAYQRK
GSTQLFCSTLCLTGYTVPPARPPPPLTKKTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCLSTYELKKKPIVTINTNSISTKCSMCQ
KNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQCHMLQIEGQSKKFCSSSCITAYKQKSAKITPCALCKSLR
SSAEMIENTNSLGKTELFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNKPTGMNSSVVPL
SQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFARSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDE
YKKINNVMAMCEYCKIEKIVKETVRFSGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKLVQNNLGGKVEEFCCEECMSKYTV
LFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMVQAASAGPPSLRKDSTPVIANVVSLASAPAA
QPTVNSNSVLQGAVPTVTAKIIGDASTQTDALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPV
FVPIPLHLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEEKKTLSQGESQTSEHELFLD
TKIFEKDQGSTYSGDLESEAVSTPHSWEEELNHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQGIQARSRTRRRHRD
GFPQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNAWKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQE
SSEPGCRVRSIKLKEDILSCTFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEPYSRFMIELTKLLKIWEP
TILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHVMRRTRTLKYSTKMTYLRFFPPLQKQESEPDK
LTVGKRKRNEDDEVPVGVEMAENTDNPLRCPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SMYD3-ZMYM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SMYD3-ZMYM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SMYD3-ZMYM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMYD3C0236733Amphetamine-Related Disorders1CTD_human
HgeneSMYD3C0236804Amphetamine Addiction1CTD_human
HgeneSMYD3C0236807Amphetamine Abuse1CTD_human