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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SNX30-PRPF4 (FusionGDB2 ID:84401)

Fusion Gene Summary for SNX30-PRPF4

Fusion gene summary

Fusion gene information	Fusion gene name: SNX30-PRPF4
	Fusion gene ID: 84401
		Hgene	Tgene
	Gene symbol	SNX30	PRPF4
	Gene ID	401548	9128
	Gene name	sorting nexin family member 30	pre-mRNA processing factor 4
	Synonyms	ATG24A	HPRP4\|HPRP4P\|PRP4\|Prp4p\|RP70\|SNRNP60
	Cytomap	9q32	9q32
	Type of gene	protein-coding	protein-coding
	Description	sorting nexin-30	U4/U6 small nuclear ribonucleoprotein Prp4PRP4 homologPRP4 pre-mRNA processing factor 4 homologPRP4/STK/WD splicing factorU4/U6 snRNP 60 kDa proteinWD splicing factor Prp4
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000374232, ENST00000604751,	ENST00000374199, ENST00000374198, ENST00000488937,
Fusion gene scores	* DoF score	12 X 9 X 11=1188	1 X 1 X 1=1
	# samples	15	1
	** MAII score	log2(15/1188*10)=-2.98550043030489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: SNX30 [Title/Abstract] AND PRPF4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SNX30(115513437)-PRPF4(116038828), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PRPF4	GO:0000398	mRNA splicing, via spliceosome	28781166

Fusion gene breakpoints across SNX30 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRPF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-D1-A3JQ-01A	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+

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Fusion Gene ORF analysis for SNX30-PRPF4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000374232	ENST00000374199	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+
In-frame	ENST00000374232	ENST00000374198	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+
5CDS-intron	ENST00000374232	ENST00000488937	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+
intron-3CDS	ENST00000604751	ENST00000374199	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+
intron-3CDS	ENST00000604751	ENST00000374198	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+
intron-intron	ENST00000604751	ENST00000488937	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000374232

SNX30

chr9

115513437

ENST00000374199

PRPF4

chr9

116038828

3104

320

164

1858

564

ENST00000374232

SNX30

chr9

115513437

ENST00000374198

PRPF4

chr9

116038828

2978

320

164

1861

565

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000374232	ENST00000374199	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+	0.003786963	0.9962131
ENST00000374232	ENST00000374198	SNX30	chr9	115513437	+	PRPF4	chr9	116038828	+	0.007429277	0.9925707

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Fusion Genomic Features for SNX30-PRPF4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SNX30	chr9	115513437	+	PRPF4	chr9	116038824	+	2.99E-05	0.9999701
SNX30	chr9	115513437	+	PRPF4	chr9	116038824	+	2.99E-05	0.9999701

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SNX30-PRPF4

Go to
FGviewer for the breakpoints of chr9:115513437-chr9:116038828
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

229_268

9.0

523.0

Repeat

Note=WD 1

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

271_318

9.0

523.0

Repeat

Note=WD 2

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

321_360

9.0

523.0

Repeat

Note=WD 3

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

363_402

9.0

523.0

Repeat

Note=WD 4

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

405_444

9.0

523.0

Repeat

Note=WD 5

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

447_487

9.0

523.0

Repeat

Note=WD 6

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374198

490_521

9.0

523.0

Repeat

Note=WD 7

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

229_268

9.0

522.0

Repeat

Note=WD 1

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

271_318

9.0

522.0

Repeat

Note=WD 2

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

321_360

9.0

522.0

Repeat

Note=WD 3

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

363_402

9.0

522.0

Repeat

Note=WD 4

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

405_444

9.0

522.0

Repeat

Note=WD 5

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

447_487

9.0

522.0

Repeat

Note=WD 6

Tgene

PRPF4

chr9:115513437

chr9:116038828

ENST00000374199

490_521

9.0

522.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX30

chr9:115513437

chr9:116038828

ENST00000374232

89_210

52.0

438.0

Domain

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Fusion Gene Sequence for SNX30-PRPF4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000374232_ENST00000374199_TCGA-D1-A3JQ-01A_SNX30_chr9_115513437_+_PRPF4_chr9_116038828_length(transcript)=3104nt_BP=320nt
GCCGGCAGAGACCAGCCGGCGGGTGGCGGCGGCCCCCAGCACGGCCGGTGCAAGGCCTCGGGTTAAGCGGCGGCCGAGCGGGGCTCGGCC
CGGGGTGCTCGGGGAGCTCGCCGCGGCGGGCAGCAGGAGGAAGCGGCGGCGGCGCGTCCCGAGCGGTGCGCGCCATGGCGGGCGGGCCCC
CCAAGGCCCTGCCGTCCACGGGGCCCCACTCCCTGCGCGACATGCCGCACCCGCTGGCCGGCTCCAGCAGCGAGGAGGCCGTGGGTGGTG
ACAGCACGCCCAGCCCGGACCTGCTGATGGCCCGCAGCTTCGGTGACAAGGCAACCAAAACTAAAGCACCCGACGACTTAGTTGCTCCGG
TCGTGAAGAAACCACACATCTATTATGGAAGTTTGGAAGAGAAGGAGAGGGAGCGTCTGGCCAAAGGAGAGTCTGGGATTTTGGGGAAAG
ACGGACTTAAAGCAGGGATCGAAGCTGGAAATATTAATATAACCTCTGGAGAAGTGTTTGAAATTGAAGAGCATATCAGCGAGCGACAGG
CAGAAGTATTGGCTGAGTTTGAGAGAAGGAAGCGAGCCCGGCAGATCAATGTTTCCACAGATGACTCAGAGGTCAAAGCTTGCCTTAGAG
CCTTGGGGGAACCCATCACACTTTTTGGAGAGGGTCCTGCTGAAAGAAGAGAAAGGTTAAGAAATATCCTCTCAGTTGTCGGTACTGATG
CCTTGAAAAAGACCAAAAAGGATGATGAGAAGTCTAAAAAGTCCAAAGAAGAGTATCAGCAAACCTGGTATCATGAAGGACCAAATAGCT
TGAAGGTGGCAAGACTATGGATTGCTAATTATTCGTTGCCCAGGGCAATGAAACGCTTGGAAGAGGCCCGACTCCATAAGGAGATTCCTG
AGACAACAAGGACCTCCCAGATGCAAGAGCTGCACAAGTCTCTCCGGTCTTTGAATAATTTTTGCAGTCAGATTGGGGATGATCGGCCTA
TCTCCTACTGTCACTTTAGTCCCAATTCCAAGATGCTGGCCACAGCTTGTTGGAGTGGGCTTTGCAAGCTCTGGTCTGTTCCTGATTGCA
ACCTCCTTCACACTCTTCGAGGGCATAACACAAATGTAGGAGCAATTGTATTCCATCCCAAATCCACTGTCTCCTTGGACCCAAAAGATG
TCAACCTGGCCTCTTGTGCGGCTGATGGCTCTGTGAAGCTTTGGAGTCTCGACAGTGATGAACCAGTGGCAGATATTGAAGGCCATACAG
TGCGTGTGGCGCGGGTAATGTGGCATCCTTCAGGACGTTTCCTGGGCACCACCTGCTATGACCGTTCATGGCGCTTATGGGATTTGGAGG
CTCAAGAGGAGATCCTGCATCAGGAAGGCCATAGCATGGGTGTGTATGACATTGCCTTCCATCAAGATGGCTCTTTGGCTGGCACTGGGG
GACTGGATGCATTTGGTCGAGTTTGGGACCTACGCACAGGACGTTGTATCATGTTCTTAGAAGGCCACCTGAAAGAAATCTATGGAATAA
ATTTCTCCCCCAATGGCTATCACATTGCAACCGGCAGTGGTGACAACACCTGCAAAGTGTGGGACCTCCGACAGCGGCGTTGCGTCTACA
CCATCCCTGCTCATCAGAACTTAGTGACTGGTGTCAAGTTTGAGCCTATCCATGGGAACTTCTTGCTTACTGGTGCCTATGATAACACAG
CCAAGATCTGGACGCACCCAGGCTGGTCCCCGCTGAAGACTCTGGCTGGCCACGAAGGCAAAGTGATGGGCCTAGATATTTCTTCCGATG
GGCAGCTCATAGCCACTTGCTCATATGACAGGACCTTCAAGCTGTGGATGGCTGAATAGATGACAATGGGAAAAGGACTTGAACCTCAAG
CTCTCTCTAAGGAGCTGTTTTCCTCAAACGAGAAGAATTGAAGTGTTTAGTTCTATCATGTTTTCTGCCAATTACCATGCATAGACCCTC
AGTAGAATTGGATTTCCATGTCAGCCCCCACTCCAGGAAGGCAGCCCAATCCCTAGGTGATGGGGAACCCCTCTCACGGTTGAAAATTTA
TTACCTTTTTACGCCCTGCCACGAACTGTGTAGACATTGTTTTTATTAATCTTTTGTTTGGCCGGGCGTGGTGGCTCACGCCTGTAATCC
TAGCACTTTGGGAGGCCGAGGTGGGTAGATCGCTTGAGCTCAGGAGTTCAAGACGAGCCTGGGCAACATGGCAAATGCCGTCTCTGCAAA
AAAATACTAAAATTAGCTGGTCGCGGTGGCTTCTGCCTGTGATTCCGGCTACTTGGGAGGCTGAGGTGGGAGGGATTGCTTAAGCCTGGG
AGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCTAGCCTGTGTGACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAATTTG
TTCGAATGCCTTATAGCCTTCCTCACAGCACCCAGGATTGTGACTGACTCTGCATTTTTAATTCTTGAAACTTGGCTTTCCATAACATGG
TACATGCTTCAGGACTACATATGACCCAGAGAGCAAGGTGGCTGAACTATAGTCTGGAAGCCCTCAGGTAAAGAGGCACATCTCACCACT
CATTGGTTAAACAATGCATCATAGCGAGCACTTTTCCTTTCCCTGGAGAATGGGATGTGAAGCAGTAGACCGCAGCCACGCCGATGGTTA
TACAGTGAAGAAGACTTCACCTCTTCCTATTGAGTTTGCTTGGAATGCTGACAGCATCAGGCAACTCTGAACTGAACATTTGCTTTGTCA
GAAAATATCTTTTTTTTTACTTTGAAGTTTGGCAACCTTCATGTTACCCCAAAGCAAAACCATTGTGTCAGGAGTCAAACAAATGTTTAG
AAAGCAAACATGACGTCTCTATTGTACAACCTCCTTTCTCTTGGCTGTTTAAAGGATGTACTTCGTGTATTAAAGGGTACTTTATGTTGA
AGTAACGAAAAAACCCTAATGGGTGTTCCTAAACCTAAACCTTTTCTTTATTCCACATTTGCTACGGTAAAATCCTGTTACAAAACTACC

>In-frame_ENST00000374232_ENST00000374199_TCGA-D1-A3JQ-01A_SNX30_chr9_115513437_+_PRPF4_chr9_116038828_length(amino acids)=564AA_start in transcript=164_stop in transcript=1858
MAGGPPKALPSTGPHSLRDMPHPLAGSSSEEAVGGDSTPSPDLLMARSFGDKATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGES
GILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILS
VVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQI
GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVAD
IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLK
EIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGL

--------------------------------------------------------------
>In-frame_ENST00000374232_ENST00000374198_TCGA-D1-A3JQ-01A_SNX30_chr9_115513437_+_PRPF4_chr9_116038828_length(transcript)=2978nt_BP=320nt
GCCGGCAGAGACCAGCCGGCGGGTGGCGGCGGCCCCCAGCACGGCCGGTGCAAGGCCTCGGGTTAAGCGGCGGCCGAGCGGGGCTCGGCC
CGGGGTGCTCGGGGAGCTCGCCGCGGCGGGCAGCAGGAGGAAGCGGCGGCGGCGCGTCCCGAGCGGTGCGCGCCATGGCGGGCGGGCCCC
CCAAGGCCCTGCCGTCCACGGGGCCCCACTCCCTGCGCGACATGCCGCACCCGCTGGCCGGCTCCAGCAGCGAGGAGGCCGTGGGTGGTG
ACAGCACGCCCAGCCCGGACCTGCTGATGGCCCGCAGCTTCGGTGACAAGCAGGCAACCAAAACTAAAGCACCCGACGACTTAGTTGCTC
CGGTCGTGAAGAAACCACACATCTATTATGGAAGTTTGGAAGAGAAGGAGAGGGAGCGTCTGGCCAAAGGAGAGTCTGGGATTTTGGGGA
AAGACGGACTTAAAGCAGGGATCGAAGCTGGAAATATTAATATAACCTCTGGAGAAGTGTTTGAAATTGAAGAGCATATCAGCGAGCGAC
AGGCAGAAGTATTGGCTGAGTTTGAGAGAAGGAAGCGAGCCCGGCAGATCAATGTTTCCACAGATGACTCAGAGGTCAAAGCTTGCCTTA
GAGCCTTGGGGGAACCCATCACACTTTTTGGAGAGGGTCCTGCTGAAAGAAGAGAAAGGTTAAGAAATATCCTCTCAGTTGTCGGTACTG
ATGCCTTGAAAAAGACCAAAAAGGATGATGAGAAGTCTAAAAAGTCCAAAGAAGAGTATCAGCAAACCTGGTATCATGAAGGACCAAATA
GCTTGAAGGTGGCAAGACTATGGATTGCTAATTATTCGTTGCCCAGGGCAATGAAACGCTTGGAAGAGGCCCGACTCCATAAGGAGATTC
CTGAGACAACAAGGACCTCCCAGATGCAAGAGCTGCACAAGTCTCTCCGGTCTTTGAATAATTTTTGCAGTCAGATTGGGGATGATCGGC
CTATCTCCTACTGTCACTTTAGTCCCAATTCCAAGATGCTGGCCACAGCTTGTTGGAGTGGGCTTTGCAAGCTCTGGTCTGTTCCTGATT
GCAACCTCCTTCACACTCTTCGAGGGCATAACACAAATGTAGGAGCAATTGTATTCCATCCCAAATCCACTGTCTCCTTGGACCCAAAAG
ATGTCAACCTGGCCTCTTGTGCGGCTGATGGCTCTGTGAAGCTTTGGAGTCTCGACAGTGATGAACCAGTGGCAGATATTGAAGGCCATA
CAGTGCGTGTGGCGCGGGTAATGTGGCATCCTTCAGGACGTTTCCTGGGCACCACCTGCTATGACCGTTCATGGCGCTTATGGGATTTGG
AGGCTCAAGAGGAGATCCTGCATCAGGAAGGCCATAGCATGGGTGTGTATGACATTGCCTTCCATCAAGATGGCTCTTTGGCTGGCACTG
GGGGACTGGATGCATTTGGTCGAGTTTGGGACCTACGCACAGGACGTTGTATCATGTTCTTAGAAGGCCACCTGAAAGAAATCTATGGAA
TAAATTTCTCCCCCAATGGCTATCACATTGCAACCGGCAGTGGTGACAACACCTGCAAAGTGTGGGACCTCCGACAGCGGCGTTGCGTCT
ACACCATCCCTGCTCATCAGAACTTAGTGACTGGTGTCAAGTTTGAGCCTATCCATGGGAACTTCTTGCTTACTGGTGCCTATGATAACA
CAGCCAAGATCTGGACGCACCCAGGCTGGTCCCCGCTGAAGACTCTGGCTGGCCACGAAGGCAAAGTGATGGGCCTAGATATTTCTTCCG
ATGGGCAGCTCATAGCCACTTGCTCATATGACAGGACCTTCAAGCTGTGGATGGCTGAATAGATGACAATGGGAAAAGGACTTGAACCTC
AAGCTCTCTCTAAGGAGCTGTTTTCCTCAAACGAGAAGAATTGAAGTGTTTAGTTCTATCATGTTTTCTGCCAATTACCATGCATAGACC
CTCAGTAGAATTGGATTTCCATGTCAGCCCCCACTCCAGGAAGGCAGCCCAATCCCTAGGTGATGGGGAACCCCTCTCACGGTTGAAAAT
TTATTACCTTTTTACGCCCTGCCACGAACTGTGTAGACATTGTTTTTATTAATCTTTTGTTTGGCCGGGCGTGGTGGCTCACGCCTGTAA
TCCTAGCACTTTGGGAGGCCGAGGTGGGTAGATCGCTTGAGCTCAGGAGTTCAAGACGAGCCTGGGCAACATGGCAAATGCCGTCTCTGC
AAAAAAATACTAAAATTAGCTGGTCGCGGTGGCTTCTGCCTGTGATTCCGGCTACTTGGGAGGCTGAGGTGGGAGGGATTGCTTAAGCCT
GGGAGGCAGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCTAGCCTGTGTGACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAT
TTGTTCGAATGCCTTATAGCCTTCCTCACAGCACCCAGGATTGTGACTGACTCTGCATTTTTAATTCTTGAAACTTGGCTTTCCATAACA
TGGTACATGCTTCAGGACTACATATGACCCAGAGAGCAAGGTGGCTGAACTATAGTCTGGAAGCCCTCAGGTAAAGAGGCACATCTCACC
ACTCATTGGTTAAACAATGCATCATAGCGAGCACTTTTCCTTTCCCTGGAGAATGGGATGTGAAGCAGTAGACCGCAGCCACGCCGATGG
TTATACAGTGAAGAAGACTTCACCTCTTCCTATTGAGTTTGCTTGGAATGCTGACAGCATCAGGCAACTCTGAACTGAACATTTGCTTTG
TCAGAAAATATCTTTTTTTTTACTTTGAAGTTTGGCAACCTTCATGTTACCCCAAAGCAAAACCATTGTGTCAGGAGTCAAACAAATGTT
TAGAAAGCAAACATGACGTCTCTATTGTACAACCTCCTTTCTCTTGGCTGTTTAAAGGATGTACTTCGTGTATTAAAGGGTACTTTATGT

>In-frame_ENST00000374232_ENST00000374198_TCGA-D1-A3JQ-01A_SNX30_chr9_115513437_+_PRPF4_chr9_116038828_length(amino acids)=565AA_start in transcript=164_stop in transcript=1861
MAGGPPKALPSTGPHSLRDMPHPLAGSSSEEAVGGDSTPSPDLLMARSFGDKQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGE
SGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNIL
SVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQ
IGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVA
DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHL
KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SNX30-PRPF4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SNX30-PRPF4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SNX30-PRPF4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	PRPF4	C4014681	RETINITIS PIGMENTOSA 70	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	PRPF4	C0013146	Drug abuse	1	CTD_human
Tgene	PRPF4	C0013170	Drug habituation	1	CTD_human
Tgene	PRPF4	C0013222	Drug Use Disorders	1	CTD_human
Tgene	PRPF4	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	PRPF4	C0035334	Retinitis Pigmentosa	1	ORPHANET
Tgene	PRPF4	C0038580	Substance Dependence	1	CTD_human
Tgene	PRPF4	C0038586	Substance Use Disorders	1	CTD_human
Tgene	PRPF4	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	PRPF4	C0740858	Substance abuse problem	1	CTD_human
Tgene	PRPF4	C1510472	Drug Dependence	1	CTD_human
Tgene	PRPF4	C4316881	Prescription Drug Abuse	1	CTD_human