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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SNX7-DPYD (FusionGDB2 ID:84443)

Fusion Gene Summary for SNX7-DPYD

Fusion gene summary

Fusion gene information	Fusion gene name: SNX7-DPYD
	Fusion gene ID: 84443
		Hgene	Tgene
	Gene symbol	SNX7	DPYD
	Gene ID	51375	1806
	Gene name	sorting nexin 7	dihydropyrimidine dehydrogenase
	Synonyms	-	DHP\|DHPDHASE\|DPD
	Cytomap	1p21.3	1p21.3
	Type of gene	protein-coding	protein-coding
	Description	sorting nexin-7	dihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenase
	Modification date	20200313	20200313
	UniProtAcc	.	Q12882
	Ensembl transtripts involved in fusion gene	ENST00000370189, ENST00000529992, ENST00000306121, ENST00000473868,	ENST00000370192, ENST00000474241, ENST00000423006, ENST00000306031,
Fusion gene scores	* DoF score	4 X 4 X 3=48	12 X 12 X 7=1008
	# samples	4	13
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1008*10)=-2.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SNX7 [Title/Abstract] AND DPYD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SNX7(99203945)-DPYD(98348930), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DPYD	GO:0006210	thymine catabolic process	10410956
Tgene	DPYD	GO:0006212	uracil catabolic process	1512248\|18075467
Tgene	DPYD	GO:0006214	thymidine catabolic process	1512248

Fusion gene breakpoints across SNX7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DPYD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-97-7554-01A	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-

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Fusion Gene ORF analysis for SNX7-DPYD

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000370189	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000370189	ENST00000474241	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000370189	ENST00000423006	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000370189	ENST00000306031	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
In-frame	ENST00000529992	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000529992	ENST00000474241	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000529992	ENST00000423006	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000529992	ENST00000306031	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
In-frame	ENST00000306121	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000306121	ENST00000474241	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000306121	ENST00000423006	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
5CDS-intron	ENST00000306121	ENST00000306031	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-3CDS	ENST00000473868	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000473868	ENST00000474241	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000473868	ENST00000423006	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-
intron-intron	ENST00000473868	ENST00000306031	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000529992

SNX7

chr1

99203945

ENST00000370192

DPYD

chr1

98348930

5416

1144

4182

1383

ENST00000306121

SNX7

chr1

99203945

ENST00000370192

DPYD

chr1

98348930

5559

1287

4325

1438

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000529992	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-	0.000269316	0.99973065
ENST00000306121	ENST00000370192	SNX7	chr1	99203945	+	DPYD	chr1	98348930	-	0.00026624	0.99973375

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Fusion Genomic Features for SNX7-DPYD

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SNX7-DPYD

Go to
FGviewer for the breakpoints of chr1:99203945-chr1:98348930
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DPYD Q12882
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX7

chr1:99203945

chr1:98348930

ENST00000306121

30_151

426.0

452.0

Domain

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

69_100

13.0

1026.0

Domain

4Fe-4S ferredoxin-type 1

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

944_976

13.0

1026.0

Domain

4Fe-4S ferredoxin-type 2

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

978_1007

13.0

1026.0

Domain

4Fe-4S ferredoxin-type 3

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

194_198

13.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

218_226

13.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

340_343

13.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

364_365

13.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

437_439

13.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

480_489

13.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

481_487

13.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

574_575

13.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

793_795

13.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

816_817

13.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

668_670

13.0

1026.0

Region

Substrate binding

Tgene

DPYD

chr1:99203945

chr1:98348930

ENST00000370192

736_737

13.0

1026.0

Region

Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX7

chr1:99203945

chr1:98348930

ENST00000370189

30_151

337.0

Domain

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Fusion Gene Sequence for SNX7-DPYD

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000529992_ENST00000370192_TCGA-97-7554-01A_SNX7_chr1_99203945_+_DPYD_chr1_98348930_length(transcript)=5416nt_BP=1144nt
GGTGGCGGCCGGCTGGGCGCGCACTCTCGGGATGGAGGGCGAGCGCCGGGCATCGCAGGCGCCCTCCTCGGGCCTCCCGGCCGGGGGCGC
CAACGGGGAGAGCCCGGGGGGCGGCGCCCCCTTTCCGGGCAGCAGTGGCTCTTCCGCCCTGCTGCAGGCGGAGGTGCTGGATCTGGACGA
GGACGAGGACGACCTGGAGGTGTTCAGCAAGGATGCCTCATTGATGGACATGAACTCCTTCAGCCCTATGATGCCAACATCCCCTTTATC
AATGATAAACCAAATCAAGTTTGAGGATGAACCAGATTTAAAGGATCTCTTCATCACAGTTGATGAACCTGAAAGTCATGTTACTACAAT
AGAAACTTTCATTACGTATAGGATTATTACTAAGACATCTCGTGGGGAATTTGACTCCAGTGAATTTGAAGTTAGGAGACGATATCAAGA
TTTCCTTTGGTTGAAGGGAAAACTGGAAGAAGCACACCCCACTCTGATTATTCCAGAACTCTCTTCTCACAAGAAGCAAGGTCCTGGCTT
GCTAAGCAGGATGGGGCAAACCGTCAGAGCTGTTGCGTCCTCAATGAGAGGAGTTAAAAACCGCCCAGAGGAGTTCATGGAAATGAATAA
CTTTATTGAACTATTTAGCCAGAAAATAAATTTGATAGATAAAATATCTCAGAGAATTTATAAGGAAGAAAGGGAATATTTTGATGAAAT
GAAAGAATATGGCCCAATTCATATTCTGTGGTCAGCGTCAGAAGAGGATCTGGTTGATACTCTAAAGGATGTTGCCAGCTGCATTGACAG
ATGCTGTAAGGCCACTGAAAAGCGGATGTCTGGACTCTCAGAGGCCCTGCTTCCTGTTGTACATGAGTACGTGCTTTATAGTGAAATGTT
AATGGGTGTTATGAAAAGAAGAGACCAAATACAAGCAGAACTGGATTCCAAAGTTGAAGTTTTGACCTATAAAAAGGCAGATACTGATCT
GCTTCCAGAGGAGATTGGAAAACTTGAAGATAAAGTGGAATGTGCTAATAATGCCCTGAAAGCAGATTGGGAGAGATGGAAACAAAATAT
GCAAAATGATATCAAGTTAGCATTTACAGATATGGCTGAGGAGAATATCCATTATTATGAACAGAGTATCCTGGCTTTAAATCCTCGAAC
ACAAACTCATGCAACTCTGCGTTCCACTTCGGCCAAGAAATTAGACAAGAAACATTGGAAAAGAAATCCTGATAAGAACTGCTTTAATTG
TGAGAAGCTGGAGAATAATTTTGATGACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTGAAATG
TGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAATCTTGATATTAAATCATTCATCACAAGTATTGCAAACAAGAACTATTATGGAGC
TGCTAAGATGATATTTTCTGACAACCCACTTGGTCTGACTTGTGGAATGGTATGTCCAACCTCTGATCTTTGTGTAGGTGGATGCAATTT
ATATGCCACTGAAGAGGGACCCATTAATATTGGTGGATTGCAGCAATTTGCTACTGAGGTATTCAAAGCAATGAGTATCCCACAGATCAG
AAATCCTTCGCTGCCTCCCCCAGAAAAAATGTCTGAAGCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATAAGTTG
TGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATCACTATATTTGAAAAACAAGAATATGTTGGTGGTTTAAGTACTTCTGAAATTCC
TCAGTTCCGGCTGCCGTATGATGTAGTGAATTTTGAGATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGCCTTTC
AGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAAGGCTACAAAGCTGCTTTCATTGGAATAGGTTTGCCAGAACCCAATAAAGATGC
CATCTTCCAAGGCCTGACGCAGGACCAGGGGTTTTATACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGAATGTG
CGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTCGTGATTGTACTTGGAGCTGGAGACACTGCCTTTGACTGTGCAACATCTGCTCT
ACGTTGTGGAGCTCGCCGTGTGTTCATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAACTTGCTAAGGA
AGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGGAAGGTTATAGTAAAAGGTGGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGA
GCAAGATGAAACTGGAAAATGGAATGAAGATGAAGATCAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCAGTTCT
GAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGGTCTCCCAGAAGTAGATCCAGAAACTATGCAAACTAG
TGAAGCATGGGTATTTGCAGGTGGTGATGTCGTTGGTTTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCTTGGTA
CATTCACAAATACGTACAGTCACAATATGGAGCTTCCGTTTCTGCCAAGCCTGAACTACCCCTCTTTTACACTCCTATTGATCTGGTGGA
CATTAGTGTAGAAATGGCCGGATTGAAGTTTATAAATCCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATTCGAAG
AGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAAACTTTCTCTCTTGATAAGGACATTGTGACAAATGTTTCCCCCAGAATCATCCG
GGGAACCACCTCTGGCCCCATGTATGGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATATTGGTG
TCAAAGTGTCACTGAACTAAAGGCTGACTTTCCAGACAACATTGTGATTGCTAGCATTATGTGCAGTTACAATAAAAATGACTGGACGGA
ACTTGCCAAGAAGTCTGAGGATTCTGGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATGGGCCT
GGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAAGCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCC
AAATGTCACTGATATTGTGAGCATCGCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGTCTGAT
GGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACTACATATGGAGGAGTGTCTGGGACAGCAATCAGACC
TATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGTGG
TCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGCAC
TGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAAGG
GAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGA
AAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGAAACTGTTTTATCCCCAAAAGGCCTATTCCTACCATCAA
GGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAAT
GTGTATCAACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCCACCAT
AACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTATGA
ACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTGTGAAACAGTTGCTGTGAACTTTCATGTCACCTACATAT
GCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCTTTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCAAA
ATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTGGTCATAAAATAGAATAATTCTTTTCTGAGGATAGTAGT
TAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCCAGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTT
CCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAATTAAGCATTTTGAAACAAAGTACTCTTTAACATACAAGA
AAATGTATCCAAGGAAACATTTTATCATTAAAAATTACCTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACA
AATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAATTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTTCG
CTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGGGAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGTGT
ACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAAAATGAGATGATAGGATAGATCCTGGTTACCACTCTTTT
GCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCACCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGC
TTCATTATTCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGCCAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTATGT
TTAAAAGAAATATATTTTTTGTTATTATTAGATAATATTTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCATT
TATCTCCTCTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAAAGTAACAATCTATGGCTTATTTCTATGACAAATTCAAG
AGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGAAATGCATATTTGCCACAAAACCTGTATTACTGAATAATATCAAATAAAATAT

>In-frame_ENST00000529992_ENST00000370192_TCGA-97-7554-01A_SNX7_chr1_99203945_+_DPYD_chr1_98348930_length(amino acids)=1383AA_start in transcript=31_stop in transcript=4182
MEGERRASQAPSSGLPAGGANGESPGGGAPFPGSSGSSALLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDE
PDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPELSSHKKQGPGLLSRMGQTVRA
VASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEEDLVDTLKDVASCIDRCCKATEKRMS
GLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIKLAFTD
MAEENIHYYEQSILALNPRTQTHATLRSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCP
TNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKM
SEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLK
EKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIV
FRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALS
PIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKF
INPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADF
PDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIAR
AAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASV
LQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNV
AFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLC

--------------------------------------------------------------
>In-frame_ENST00000306121_ENST00000370192_TCGA-97-7554-01A_SNX7_chr1_99203945_+_DPYD_chr1_98348930_length(transcript)=5559nt_BP=1287nt
ACTCTCGGGATGGAGGGCGAGCGCCGGGCATCGCAGGCGCCCTCCTCGGGCCTCCCGGCCGGGGGCGCCAACGGGGAGAGCCCGGGGGGC
GGCGCCCCCTTTCCGGGCAGCAGTGGCTCTTCCGCCCTGCTGCAGGCGGAGGTGCTGGATCTGGACGAGGACGAGGACGACCTGGAGGTG
TTCAGCAAGGATGCCTCATTGATGGACATGAACTCCTTCAGCCCTATGATGCCAACATCCCCTTTATCAATGATAAACCAAATCAAGTTT
GAGGATGAACCAGATTTAAAGGATCTCTTCATCACAGTTGATGAACCTGAAAGTCATGTTACTACAATAGAAACTTTCATTACGTATAGG
ATTATTACTAAGACATCTCGTGGGGAATTTGACTCCAGTGAATTTGAAGTTAGGAGACGATATCAAGATTTCCTTTGGTTGAAGGGAAAA
CTGGAAGAAGCACACCCCACTCTGATTATTCCACCATTGCCAGAAAAGTTTATAGTAAAAGGAATGGTGGAACGCTTTAACGATGACTTC
ATTGAGACACGCAGGAAGGCTTTACATAAATTTTTGAACCGAATTGCTGATCATCCAACTTTAACATTTAATGAAGACTTCAAAATTTTT
CTCACTGCACAAGCTTGGGAACTCTCTTCTCACAAGAAGCAAGGTCCTGGCTTGCTAAGCAGGATGGGGCAAACCGTCAGAGCTGTTGCG
TCCTCAATGAGAGGAGTTAAAAACCGCCCAGAGGAGTTCATGGAAATGAATAACTTTATTGAACTATTTAGCCAGAAAATAAATTTGATA
GATAAAATATCTCAGAGAATTTATAAGGAAGAAAGGGAATATTTTGATGAAATGAAAGAATATGGCCCAATTCATATTCTGTGGTCAGCG
TCAGAAGAGGATCTGGTTGATACTCTAAAGGATGTTGCCAGCTGCATTGACAGATGCTGTAAGGCCACTGAAAAGCGGATGTCTGGACTC
TCAGAGGCCCTGCTTCCTGTTGTACATGAGTACGTGCTTTATAGTGAAATGTTAATGGGTGTTATGAAAAGAAGAGACCAAATACAAGCA
GAACTGGATTCCAAAGTTGAAGTTTTGACCTATAAAAAGGCAGATACTGATCTGCTTCCAGAGGAGATTGGAAAACTTGAAGATAAAGTG
GAATGTGCTAATAATGCCCTGAAAGCAGATTGGGAGAGATGGAAACAAAATATGCAAAATGATATCAAGTTAGCATTTACAGATATGGCT
GAGGAGAATATCCATTATTATGAACAGAGTATCCTGGCTTTAAATCCTCGAACACAAACTCATGCAACTCTGCGTTCCACTTCGGCCAAG
AAATTAGACAAGAAACATTGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGTGAGAAGCTGGAGAATAATTTTGATGACATCAAGCAC
ACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTGAAATGTGCAGATGCCCCGTGTCAGAAGAGCTGTCCAACTAAT
CTTGATATTAAATCATTCATCACAAGTATTGCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAACCCACTTGGTCTG
ACTTGTGGAATGGTATGTCCAACCTCTGATCTTTGTGTAGGTGGATGCAATTTATATGCCACTGAAGAGGGACCCATTAATATTGGTGGA
TTGCAGCAATTTGCTACTGAGGTATTCAAAGCAATGAGTATCCCACAGATCAGAAATCCTTCGCTGCCTCCCCCAGAAAAAATGTCTGAA
GCCTATTCTGCAAAGATTGCTCTTTTTGGTGCTGGGCCTGCAAGTATAAGTTGTGCTTCCTTTTTGGCTCGATTGGGGTACTCTGACATC
ACTATATTTGAAAAACAAGAATATGTTGGTGGTTTAAGTACTTCTGAAATTCCTCAGTTCCGGCTGCCGTATGATGTAGTGAATTTTGAG
ATTGAGCTAATGAAGGACCTTGGTGTAAAGATAATTTGCGGTAAAAGCCTTTCAGTGAATGAAATGACTCTTAGCACTTTGAAAGAAAAA
GGCTACAAAGCTGCTTTCATTGGAATAGGTTTGCCAGAACCCAATAAAGATGCCATCTTCCAAGGCCTGACGCAGGACCAGGGGTTTTAT
ACATCCAAAGACTTTTTGCCACTTGTAGCCAAAGGCAGTAAAGCAGGAATGTGCGCCTGTCACTCTCCATTGCCATCGATACGGGGAGTC
GTGATTGTACTTGGAGCTGGAGACACTGCCTTTGACTGTGCAACATCTGCTCTACGTTGTGGAGCTCGCCGTGTGTTCATCGTCTTCAGA
AAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGATGGAACTTGCTAAGGAAGAAAAGTGTGAATTTCTGCCATTCCTGTCCCCACGG
AAGGTTATAGTAAAAGGTGGGAGAATTGTTGCTATGCAGTTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAATGAAGATGAAGAT
CAGATGGTCCATCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGTTCAGTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATA
AAATTTAACAGATGGGGTCTCCCAGAAGTAGATCCAGAAACTATGCAAACTAGTGAAGCATGGGTATTTGCAGGTGGTGATGTCGTTGGT
TTGGCTAACACTACAGTGGAATCGGTGAATGATGGAAAGCAAGCTTCTTGGTACATTCACAAATACGTACAGTCACAATATGGAGCTTCC
GTTTCTGCCAAGCCTGAACTACCCCTCTTTTACACTCCTATTGATCTGGTGGACATTAGTGTAGAAATGGCCGGATTGAAGTTTATAAAT
CCTTTTGGTCTTGCTAGCGCAACTCCAGCCACCAGCACATCAATGATTCGAAGAGCTTTTGAAGCTGGATGGGGTTTTGCCCTCACCAAA
ACTTTCTCTCTTGATAAGGACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTATGGCCCTGGACAA
AGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATATTGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTTCCAGAC
AACATTGTGATTGCTAGCATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCTGGAGCAGATGCC
CTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATGGGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATC
TGCCGCTGGGTTAGGCAAGCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATCGCAAGAGCTGCA
AAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGTCTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTG
GGGATTGCAAAGCGAACTACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCT
CTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAG
GTATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAA
GAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAG
AAACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTT
TCACCACTTAAGAGAAACTGTTTTATCCCCAAAAGGCCTATTCCTACCATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACA
TTTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTACATGACCTGTAAT
GATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCCACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGT
GTTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTG
TGTTAAGGTGATTTGTGAAACAGTTGCTGTGAACTTTCATGTCACCTACATATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTC
TTTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCAAAATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATG
ACCATTCAATTAGTGGTCATAAAATAGAATAATTCTTTTCTGAGGATAGTAGTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGC
CAGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTTCCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCT
AATTGTAAGTGAAATTAAGCATTTTGAAACAAAGTACTCTTTAACATACAAGAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTA
CCTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACAAATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGA
TAAGAAAGCCTAAAATTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTTCGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAG
GGAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGTGTACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAA
CTATGTTCCTAACAAAATGAGATGATAGGATAGATCCTGGTTACCACTCTTTTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTC
ACCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGCTTCATTATTCAAGAATGAAAAATATAATGTTGATAAT
ATATATTAAGTGTGCCAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTATGTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATA
TTTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCATTTATCTCCTCTTCATGGCATCTTCAATATGAATCTATA
AGTAGTAAATCAGAAAGTAACAATCTATGGCTTATTTCTATGACAAATTCAAGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAG

>In-frame_ENST00000306121_ENST00000370192_TCGA-97-7554-01A_SNX7_chr1_99203945_+_DPYD_chr1_98348930_length(amino acids)=1438AA_start in transcript=9_stop in transcript=4325
MEGERRASQAPSSGLPAGGANGESPGGGAPFPGSSGSSALLQAEVLDLDEDEDDLEVFSKDASLMDMNSFSPMMPTSPLSMINQIKFEDE
PDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVRRRYQDFLWLKGKLEEAHPTLIIPPLPEKFIVKGMVERFNDDFIET
RRKALHKFLNRIADHPTLTFNEDFKIFLTAQAWELSSHKKQGPGLLSRMGQTVRAVASSMRGVKNRPEEFMEMNNFIELFSQKINLIDKI
SQRIYKEEREYFDEMKEYGPIHILWSASEEDLVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELD
SKVEVLTYKKADTDLLPEEIGKLEDKVECANNALKADWERWKQNMQNDIKLAFTDMAEENIHYYEQSILALNPRTQTHATLRSTSAKKLD
KKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCG
MVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIF
EKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSK
DFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVI
VKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLAN
TTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFS
LDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALEL
NLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIA
KRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQ
DWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGE

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Top

Fusion Gene PPI Analysis for SNX7-DPYD

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SNX7-DPYD

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	DPYD	Q12882	DB03147	Flavin adenine dinucleotide		Small molecule	Approved
Tgene	DPYD	Q12882	DB09257	Gimeracil	Inhibitor	Small molecule	Approved
Tgene	DPYD	Q12882	DB03247	Flavin mononucleotide		Small molecule	Approved\|Investigational
Tgene	DPYD	Q12882	DB09327	Tegafur-uracil	Antagonist	Small molecule	Approved\|Investigational

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Related Diseases for SNX7-DPYD

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SNX7	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	DPYD	C1959620	Dihydropyrimidine Dehydrogenase Deficiency	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	DPYD	C0009402	Colorectal Carcinoma	5	CTD_human
Tgene	DPYD	C0009404	Colorectal Neoplasms	5	CTD_human
Tgene	DPYD	C0024623	Malignant neoplasm of stomach	3	CTD_human
Tgene	DPYD	C0038356	Stomach Neoplasms	3	CTD_human
Tgene	DPYD	C1708349	Hereditary Diffuse Gastric Cancer	3	CTD_human
Tgene	DPYD	C0030297	Pancreatic Neoplasm	2	CTD_human
Tgene	DPYD	C0034139	Purine-Pyrimidine Metabolism, Inborn Errors	2	CTD_human
Tgene	DPYD	C0036341	Schizophrenia	2	CTD_human
Tgene	DPYD	C0346647	Malignant neoplasm of pancreas	2	CTD_human
Tgene	DPYD	C1510586	Autism Spectrum Disorders	2	CTD_human
Tgene	DPYD	C3495551	Dihydropyrimidinuria	2	CTD_human
Tgene	DPYD	C4304578	1p21.3 microdeletion syndrome	2	ORPHANET
Tgene	DPYD	C0004352	Autistic Disorder	1	CTD_human
Tgene	DPYD	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	DPYD	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	DPYD	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	DPYD	C0018671	Head and Neck Neoplasms	1	CTD_human
Tgene	DPYD	C0018675	Head Neoplasms	1	CTD_human
Tgene	DPYD	C0023012	Language Delay	1	CTD_human
Tgene	DPYD	C0023014	Language Development Disorders	1	CTD_human
Tgene	DPYD	C0024121	Lung Neoplasms	1	CTD_human
Tgene	DPYD	C0027533	Neck Neoplasms	1	CTD_human
Tgene	DPYD	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	DPYD	C0027765	nervous system disorder	1	CTD_human
Tgene	DPYD	C0027947	Neutropenia	1	CTD_human
Tgene	DPYD	C0028754	Obesity	1	CTD_human
Tgene	DPYD	C0241210	Speech Delay	1	CTD_human
Tgene	DPYD	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	DPYD	C0270612	Leukoencephalopathy	1	CTD_human
Tgene	DPYD	C0278996	Malignant Head and Neck Neoplasm	1	CTD_human
Tgene	DPYD	C0454655	Semantic-Pragmatic Disorder	1	CTD_human
Tgene	DPYD	C0678222	Breast Carcinoma	1	CTD_human
Tgene	DPYD	C0746787	Cancer of Neck	1	CTD_human
Tgene	DPYD	C0751177	Cancer of Head	1	CTD_human
Tgene	DPYD	C0751257	Auditory Processing Disorder, Central	1	CTD_human
Tgene	DPYD	C0887900	Upper Aerodigestive Tract Neoplasms	1	CTD_human
Tgene	DPYD	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	DPYD	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	DPYD	C1858991	Childhood Ataxia with Central Nervous System Hypomyelinization	1	CTD_human
Tgene	DPYD	C2239176	Liver carcinoma	1	CTD_human
Tgene	DPYD	C4704874	Mammary Carcinoma, Human	1	CTD_human
Tgene	DPYD	C4721453	Peripheral Nervous System Diseases	1	CTD_human