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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOBP-VTA1 (FusionGDB2 ID:84481)

Fusion Gene Summary for SOBP-VTA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SOBP-VTA1
Fusion gene ID: 84481
HgeneTgene
Gene symbol

SOBP

VTA1

Gene ID

55084

51534

Gene namesine oculis binding protein homologvesicle trafficking 1
SynonymsJXC1|MRAMSC6orf55|DRG-1|DRG1|HSPC228|LIP5|My012|SBP1
Cytomap

6q21

6q24.1-q24.2

Type of geneprotein-codingprotein-coding
Descriptionsine oculis-binding protein homologjackson circler protein 1vacuolar protein sorting-associated protein VTA1 homologLYST-interacting protein 5SKD1-binding protein 1Vps20-associated 1 homologdopamine-responsive gene 1 proteinhomolog of mouse SKD1-binding protein 1vesicle (multivesicular body) trafficking 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000317357, ENST00000494935, 
ENST00000367630, ENST00000367621, 
ENST00000452973, ENST00000491881, 
Fusion gene scores* DoF score8 X 6 X 6=28810 X 12 X 6=720
# samples 813
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOBP [Title/Abstract] AND VTA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOBP(107908379)-VTA1(142510562), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SOBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across VTA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-CC-5261SOBPchr6

107908379

+VTA1chr6

142510562

+


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Fusion Gene ORF analysis for SOBP-VTA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000317357ENST00000367630SOBPchr6

107908379

+VTA1chr6

142510562

+
In-frameENST00000317357ENST00000367621SOBPchr6

107908379

+VTA1chr6

142510562

+
In-frameENST00000317357ENST00000452973SOBPchr6

107908379

+VTA1chr6

142510562

+
5CDS-3UTRENST00000317357ENST00000491881SOBPchr6

107908379

+VTA1chr6

142510562

+
intron-3CDSENST00000494935ENST00000367630SOBPchr6

107908379

+VTA1chr6

142510562

+
intron-3CDSENST00000494935ENST00000367621SOBPchr6

107908379

+VTA1chr6

142510562

+
intron-3CDSENST00000494935ENST00000452973SOBPchr6

107908379

+VTA1chr6

142510562

+
intron-3UTRENST00000494935ENST00000491881SOBPchr6

107908379

+VTA1chr6

142510562

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000317357SOBPchr6107908379+ENST00000367630VTA1chr6142510562+788713286591840393
ENST00000317357SOBPchr6107908379+ENST00000367621VTA1chr6142510562+226513286591840393
ENST00000317357SOBPchr6107908379+ENST00000452973VTA1chr6142510562+236813286591759366

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000317357ENST00000367630SOBPchr6107908379+VTA1chr6142510562+0.0003505810.9996494
ENST00000317357ENST00000367621SOBPchr6107908379+VTA1chr6142510562+0.0040878840.9959122
ENST00000317357ENST00000452973SOBPchr6107908379+VTA1chr6142510562+0.0036690270.99633104

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Fusion Genomic Features for SOBP-VTA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SOBPchr6107908379+VTA1chr6142510562+0.162526440.83747363
SOBPchr6107908379+VTA1chr6142510562+0.162526440.83747363

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOBP-VTA1


check button Go to

FGviewer for the breakpoints of chr6:107908379-chr6:142510562

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOBPchr6:107908379chr6:142510562ENST00000317357+57142_180223.01271.3333333333333Zinc fingerFCS-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOBPchr6:107908379chr6:142510562ENST00000317357+57346_552223.01271.3333333333333Compositional biasPro-rich
HgeneSOBPchr6:107908379chr6:142510562ENST00000317357+57740_763223.01271.3333333333333Compositional biasPro-rich
HgeneSOBPchr6:107908379chr6:142510562ENST00000317357+57216_256223.01271.3333333333333Zinc fingerFCS-type 2


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Fusion Gene Sequence for SOBP-VTA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000317357_ENST00000367630_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(transcript)=7887nt_BP=1328nt
AGCCACGCCCGCTCGAGAGCCGGGGGGCTGTCCTCGCCCCCCCCACCTTTCCCCTCCCTCCGACCCCCTCCCGGCCGCGCTCCCTCCCCT
CCTCCCGCGCCGGCCCCCGGCCCGCCCCCGGCTCGGCTCGCGGGAGGCGCTGGGCGCCGGGGCTGGCGCGCTCTCCCGGGCTCACACACA
GCCGCGCACGCACGCCCGGGGCCGCTCTCCGCGCCGGCCCTTGCTCCCCGCGCCCATGCGGACGGACCGAGCGACGGAAGATGGCTGACG
ACTCCACGGGGCCCCGAGGATGCGGCCCGGCGGCGGCGGCGGCGGGAGCGGCAGCGGCAGCGAGGGCGGCAGGGGCAGCGGCAGCAGCGG
CGGCGTTGGCTGCGGCGGCGGCGGCGGCGGCAGCAGGAGCCGGAGCGACGGCGGCGGCATCCCCGAGACTCTCCGCACTATCCTTACCCG
TGACAGCCACTGACGTCCTCCGCCGCTAGAAGAGACCCCGCTTCTCGGCGCCTGCCCTCCCCCTCGCGGCTCGGTCCGGCCCCGCCAGCA
CCGCTACCTCCGCCAGCCTCGCCACCATCAGCACCACCTCCACCGCCGCCGCCGCCGCCACCACCACCGCCGGCGGCGGCAGCAGCCATT
TCATCTCCACAGAAACCAGACACAAAAACATGGCAGAAATGGAGAAAGAAGGGAGACCTCCCGAAAATAAACGGAGCAGGAAGCCGGCTC
ACCCAGTGAAAAGGGAGATCAATGAGGAGATGAAGAACTTTGCAGAAAACACCATGAATGAACTCCTTGGCTGGTATGGCTATGATAAGG
TTGAATTAAAAGATGGTGAGGATATTGAATTCAGGAGCTACCCTACAGATGGGGAGAGCCGGCAGCACATTTCTGTTCTCAAAGAAAATT
CTTTGCCAAAACCAAAATTACCCGAGGACAGTGTTATTTCACCATACAATATAAGCACAGGCTATTCAGGGCTTGCCACTGGAAATGGAC
TCAGTGACTCACCTGCAGGGTCAAAGGATCATGGCAGTGTGCCCATTATTGTACCTTTAATTCCACCACCTTTCATAAAGCCACCAGCAG
AAGATGATGTGTCAAATGTACAAATAATGTGTGCCTGGTGCCAGAAAGTGGGAATCAAGCGCTATTCCCTGAGTATGGGAAGTGAGGTGA
AAAGCTTCTGCAGCGAGAAGTGCTTTGCGGCCTGCCGACGAGCCTACTTCAAGAGAAATAAGGCTAGAGATGAAGATGGACATGCTGAAA
ATTTTCCCCAGCAGCACTATGCTAAGGAAACTCCAAGGCTTGCCTTCAAGAATAACTGCGAACTACTTAATGTGAAACACAGGAAGTATG
CCAGATGGAAGGCAACATACATCCATAATTGTTTAAAGAATGGGGAGACTCCTCAAGCAGGCCCTGTTGGAATTGAAGAAGATAATGATA
TTGAAGAAAATGAAGATGCTGGAGCAGCCTCTCTGCCCACTCAGCCAACTCAGCCATCATCATCTTCAACTTATGACCCAAGCAACATGC
CATCAGGCAACTATACTGGAATACAGATTCCTCCGGGTGCACACGCTCCAGCTAATACACCAGCAGAAGTGCCTCACAGCACAGGTGTAG
CAAGTAATACTATCCAACCTACTCCACAGACTATACCTGCCATTGATCCCGCACTTTTCAATACAATTTCCCAGGGGGATGTTCGTCTAA
CCCCAGAAGACTTTGCTAGAGCTCAGAAGTACTGCAAATATGCTGGCAGTGCTTTGCAGTATGAAGATGTAAGCACTGCTGTCCAGAATC
TACAAAAGGCTCTCAAGTTACTGACGACAGGCAGAGAATGAAGCCTTTGTATGACAGACCCATGTATTTTTGGCATGAGGAACTAACAGT
CCATTACTCTATCTTCAGCCTATCAGGATCACAGTTTTAAGGAAGACTTGGTTTTGTTGAATATGACAATGAAATCTGTGTGTATCAGAT
TTTTATTGAAGCATTCATCAGCAGCCTCAACCAGTTTTCATTGTCCATTTACTAGATTCAATCGTCTCTGAGTATATAGGGCTGATGTTA
GCAAGACCCTAAAAATGTCCATTGAACCCTGCTTCAAAAAATGAAAACACACCTCTATAAAATGTGTACTGGGAATAAGCTTTGTATTTA
CATACATTAGGGGAATTTTTTAAAATCTGTAATGTTTGGACAAACAGATGATATTACTTTGCTATAAAATTATAAATGTAACTTTTAATA
AAGATAGCCAGAATATTCTAAATTAGAAATTACGTTTTTGTTTCCCTCAAGACATAAAACAAATATAAACATTCTAAACTGCTGGATGAA
TCTGAAAAGACATTAAGTTCAAATTTTAATTTATTCTCATATTAAATATAACTCCATTAAAAGTTTAAAATTTCATGGGAGAAAATATAA
TAAGGTAAAGAGGTAGAATCACTTTCAGACTTAAGAATAATGTTGATTTCCCAAGTGCTTTACCTTATCTGTTAAAGCGTAAGATGAATT
GGTATTTGCTTCATAGGCAGTTTGACTGCATGTATTAGAGAATGAAAAGAAGATATTTGTAGTAATGCCTGGAAACTTGGTGCTTTAAAT
TAAGGTACTCCTCTGCTGCTGTAGAATGGATTCCACACAGTGGATAGCTATGGGTGATTCAGAATATTATGTTTAGATTCCCATTTGTTA
AGTTTATAAGTTTTGTGGGGAATTATGAACTTACTGTGTACTACCTGCATTTGTGCTGTGTGAAAAATAAATACAAGGATTCGTTTAGCT
AATTCAACTTACTACAAAGACAAATGTCTGTTTTTATTTGCCTGCTAGGATTGTCTTTTTTAAAAGTCATTTTTATTTATAGGAATATGG
GTGTTTCTATAGGAAGAAACAGGTTTTTTGTTTTTTGTTTTTTAAGATAAATTTGACAAAGTTAACTGAAATTTATCTGGTCCATTTTAT
TCATGCTACTAAGATGGGAATCTTTAAACACAAGGGTCAGCAAGCTTTGGCCCATGGATTGGCCACCTGTTACGTAAATAAAGTTTCTTT
GAAACAAGCCTACACTCATTCATTTATGTTTTGTCTGTGGTTGCTTTCCACAACTGCAGAGTTGTATGGCTTGCAAGTCTAAAAACATTT
ACTATTTGGCCCTCTAAGAAAAAGTTAAGACACCTAGTCTAATGGCCTTTTGGGAAAAAACAAATCACTAACTCATAATCATTTATATCC
ATTATTTTCTGCATAAATGTAATGCTATTGTACAGGGTTTGGTAGAATAAATATTCAGACTGACTAAACTGTTCTAAATCCTCACAAAAA
AGTCCCCAAACAACATGCCTCCTAAAAAACATTTTCCTATCTTTTACAAGAGGTATGAACATTTGTAGGGTTCCACATTTGCATCTAGAA
ATCCAATGCTCTTTAGAATGTTATTACGAATAGAAAGATGGCCAGGATGACCTTTAGTGTTACATGATGTTCAGCAAATTTTAATTCAAA
CCTTGATATGCCTGGACACTGAAAAGTAAACGCATCACCTCCTATTTTATACCCTACCTTCTGGTTCCCAATTGGGAGAGCACATAGAGG
GAAGGAGACAATATAGAAACTACGGAGTCCGCTGGTAGTGGGCTGCATGGTGTGACAGAGCCCTTCTCTGTAAAATGGAAATGACACCAC
TAGCCATCTCAATAGTTACAAGAATTAAAAGAGATACAGTACCTGAAGTGCTTAGCGCATGGTAGCATTTCATAAATGTTTAGTGTCAAT
ACTAATGCTCTAATAATGTAAATTGTTAATAATTTATTTCCCTAATATCAGGAAATCCCAGTTGTCTATGTGGCCCAGTGCTTAAAAACG
CCTTCTTGCATGAGGGGATTGAACTATACAATGTTTGTTAACTTTGTATTTGTATTTTTTCCTATAAAATCTTAAAATAAAATTAGGAGA
TGTGTTCTGATGTAACAGTAGGATTAGCAATTTTCATTTATTCCTTCCATATATATTTACTGAATGGCTACTATATGCCTGGTATTGTTC
TTTGAAAGCAGAAACAGCAGGAAAAAAAGTCCCTCCCTCATAGAGTTTACATTCTAAAAGGGAGGAAATAGATAATAAAATATACATTAC
ATTTAATCAGTGGCTCTCCGAGTGTGATTAGAAATACAAATTTTGGGCCCCACCTGTCCTACCCAATCAGAAACTCTAGGGATGGGTCCC
AGCCTTCTGAGTTTTAAGAGACACTTAAGGTGGTCCCTAAAGTTCGAGTGGTTTAGCTCTACCCAAATCAGAAATATTGCAAGTCTGAGA
AAAGAGATTCTCCTCAAACCGGTTCTCAAAGGTGTCTCTGGACGACCGGCATCAGCATCACCTGCGAACTTGCTAGAAAGTTCTGGGGAC
CACACTATGGGAACTTCTGTATTAAATAGTGATAAATGCTATGGAGGAAACATTGAGGACAGGATAGGAGATGCTTAGGTGTGTACAGAC
ATATGCATATTTCAATAGAATAGCCAGGATAGACCTCCCTGAGGTAACATTTGAGCAAAGAAGGAAAAGAGTAACTAGTATGCAGATACA
TACATGGAGGAAGAGCATTCCCAACAGGTAGACAGAAATCAGGTCAGAGGGTAAAAGCAGGAGAAAGGCTGGTGAGGGAGCTAAAAGCTT
AGGATCATAAAGCTTTTTTGTAAGACACTTGACTGGGAGCTATATGGAAAGGTTTTCAGAAGAAACGTAGCCTGATGTGACTTAACTTTT
GAAATAATCATATTGGCTCCTATGTTGAGAATAGACCGTAAGGTGGGTGGTAAGTAAGGGAGGAAGCTGGGAGACCAGTTAAAAAGAGTA
TTAACAATAGGCCGGGGGCGGTGGTTCGCACCTGCAATCCCAGCACTTTGGGAGCCAAGGCAGGCGGATCATCTGAGGTCAGGAGTATAT
ATTTATTAATATATAAATATGTATTTATATATAAATCATAAATATATTAATAAATATATAATATATATATTAGCCTGGCATGGTGGCACA
TACCTCTAATCTCAGCTACTGAAGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCGTGCCAC
TGCACTCCAGCCTGGGCGACAGAGCGAGACTCCTTCTCAAAAAAAAAAAAAGTATTACAATAATCAAGGTGAGATATTATGATGTCTTAG
TCCAGGAGTAGCCTTGGAGGTAATAAAACGGGATTGGTTTCTGGCGGCTTTTTTTTAGGTAGAGCCACAGGATTTCTGTAAACTGGATGT
GAGGTACGAACATAAGAGAAGGAGTAAAGGTTGACTCCAGATTTTTCACCTGAATGCCTGAAAGGAATGAGTAATCATGTACTGCAGTAG
GGAAAGTTGCCGAATTCCTCTCTCACTTAGACTGAAGTACAATGTTTCCAAGTTTTTGTGACCAGCCCAAGTGAAACTGATAACGGTGTT
TTGTCAATGCGGCAGAGGGAGAAGAAGAAATAAGGTTCTGCTGACAATGATTGCCACAGATATCTCACCAAATCACTGCTGAACTGGAGC
TGCAAGCCAAGAATAGTTCCCATGGTTAGCATGGCCTAGGAAGTTTACTGACATCAGGACTACACCAAGAAAAAGACTCCAGTTATGGGT
CTTGAAAATTAATATCCTCAGATGTTTTTAGAATTTATATATGACTTGTAATTCTAGAAATTTGAGAATTCTATGTATGCATTGAAAGAT
TATATACTGTCTTTTCTAAAGAAACACCCTAATAGCAGCATTGTACAAATATTTTCAACTCTAAAAGAATAATAGCTAATGGAGTTGATG
GGTTTTGGTTTTCATATGAGAAGTATCCTTCCCTGGTTGGTTGTAATCTTTGAAGTCTATGTGGAATTCTAAGACTGCAGGCTTGTTCAT
TGGAGTACACTTAAGTAGGACAAATTCTAAGTAAGCAACACTTCAATAATAATCATAATAGCTAACATTTCAATGTTTACTAAATGTCAG
ATACTATTCTAAGTATTTTGCATATATTAATTCATTTAATCTTCACAGTGGTCCTGAGAGGTAGGCTTTATTTCTGTTTTAAGATGAGGA
AAGGGAGCCACAGAGTAACAAATTTGCCTAAGGTAACACAGCTAATATTTATTTCTAAGCTCAGACTGCCTGTTTCAGATCATAAGAAGT
ATCATCCATGTCAGTAAGTCACCTGTTACATTGTAAGTACAATGAGATGTTATGAGTTCCACATTATCAAGGTCATTGGACAGTTCCTTT
TATTAGTGAGGTGTTAGCACCTAAATTTTTCTATTATCTGGGCCATATGTTCCAATTGACAGTGCTAGGCAGTGAACACAGGGTATGAAC
TTGAAAATCTGATTGCACCCTCAATATCTGGAATATACACTGATCTATGACCTGAAATTGTATGGACTGCAGCAATCCAAGGGGACACTA
AGCAGGGTTTGAGTAATGCTACAATGGATTTATAGGTCATTTTGGAGAAGGTGTTCCACATCATTAGGGAGTCTGGGTTTCCCAGATGTG
CCTGTTTTATCCTTTTTATTTTAAATAACATCACTGTCTTTCCTAACTAAAAATTCTTCATCTTCAGGAAATAAGATTGAGATACGGACT
GAAAATATAAAATTAGCAATAATGTTTATTATTAGATACTTCCTCAATTAAATTTCTCCCTGAAAGTCTTAGGCAAAAGCCCCTGTCTCT
TACTTCATATATCAAGTTTGGAGGGAAAGACATAATTGCATAGCAGTATTCCATGAATATAACTTAATGGGGAACTGGCTTCAGAGTTCA
GCAATATTGGGAAGTCTTGTCAAATATTAAGTCATTCATATGTTCAAAAATATTAATATGTATTGAGCATCTACCATCAAATATTTAATA
TGATAATGCCATACTGGATATTATATACGAGTTACAATAATTCTTCCTAAAGTCAGGGAAAGCTTCACAGATAAGGTTGAGCTGAAGGTT
TGGCAGGCAGGGAAGCAAGGAGAAGTTAGCAGAGAGAAAAGCACAAGCAACACCATGGAGGAACAAATGTGGGCAATTCAGGTAACTCGA
GTAATTTAGTGTTACTATGCATATGGCCTATGGAGGCCAGGAGTGTAAATGTATTATGGCTGGGGCGGGGGGCTAGGGAATGTGTTATGA
CTAAATTGTATCCCTTCAGAATTCATATTTTGAAGCACTGATCTCCAGTGTGTCTGTGTTCAGAGGCAGGTCCCATAGGGAGGCAATTAA
GGTTACATGAGATCATAAAGGTGAGGCCCTAATCCTATAGGTCTGCTGTCATTACAAGAAGAGGAAGAGCCACCGGAGCTGGCTCATTCT
GCACGTGTACAGAGAAGAGGCCATGTGAGGACACGCAGAGGCTCGAATATGCTCTCAACCCTATCAGTTGCCTGCTTTAATTCATCCCAT
GGAATTGTTTTGTCTTTTCGACCCCTCGGCTATGTTATTTGTATTGTGATATAGGGGATATTCGGAGTCCTCTGAGACGGGACAAGGACA
CTGGACGGTCTATTGTGCCATGCTTATATATTTTCTGTATACAATGCTTTCTGTATAAAACCAGTAATACCTGAGAAACAACAGTAACTT
GACAAAATTACTATTGATCACTTAACTTTATGTATCACGTAAGTTAAACTTTATTTATTTACATGTGTCTCCCTCATTAGATGCTAAGTT
CCTTGATATTTTATACATTTGTGAATTCCTGGTAATTCACATGAAGCTTGATGCATTGTAAGTATTCTGACCTGGTGAAATAAATATACG

>In-frame_ENST00000317357_ENST00000367630_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(amino acids)=393AA_start in transcript=659_stop in transcript=1840
MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPED
SVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFA
ACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLNVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAA
SLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQK

--------------------------------------------------------------
>In-frame_ENST00000317357_ENST00000367621_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(transcript)=2265nt_BP=1328nt
AGCCACGCCCGCTCGAGAGCCGGGGGGCTGTCCTCGCCCCCCCCACCTTTCCCCTCCCTCCGACCCCCTCCCGGCCGCGCTCCCTCCCCT
CCTCCCGCGCCGGCCCCCGGCCCGCCCCCGGCTCGGCTCGCGGGAGGCGCTGGGCGCCGGGGCTGGCGCGCTCTCCCGGGCTCACACACA
GCCGCGCACGCACGCCCGGGGCCGCTCTCCGCGCCGGCCCTTGCTCCCCGCGCCCATGCGGACGGACCGAGCGACGGAAGATGGCTGACG
ACTCCACGGGGCCCCGAGGATGCGGCCCGGCGGCGGCGGCGGCGGGAGCGGCAGCGGCAGCGAGGGCGGCAGGGGCAGCGGCAGCAGCGG
CGGCGTTGGCTGCGGCGGCGGCGGCGGCGGCAGCAGGAGCCGGAGCGACGGCGGCGGCATCCCCGAGACTCTCCGCACTATCCTTACCCG
TGACAGCCACTGACGTCCTCCGCCGCTAGAAGAGACCCCGCTTCTCGGCGCCTGCCCTCCCCCTCGCGGCTCGGTCCGGCCCCGCCAGCA
CCGCTACCTCCGCCAGCCTCGCCACCATCAGCACCACCTCCACCGCCGCCGCCGCCGCCACCACCACCGCCGGCGGCGGCAGCAGCCATT
TCATCTCCACAGAAACCAGACACAAAAACATGGCAGAAATGGAGAAAGAAGGGAGACCTCCCGAAAATAAACGGAGCAGGAAGCCGGCTC
ACCCAGTGAAAAGGGAGATCAATGAGGAGATGAAGAACTTTGCAGAAAACACCATGAATGAACTCCTTGGCTGGTATGGCTATGATAAGG
TTGAATTAAAAGATGGTGAGGATATTGAATTCAGGAGCTACCCTACAGATGGGGAGAGCCGGCAGCACATTTCTGTTCTCAAAGAAAATT
CTTTGCCAAAACCAAAATTACCCGAGGACAGTGTTATTTCACCATACAATATAAGCACAGGCTATTCAGGGCTTGCCACTGGAAATGGAC
TCAGTGACTCACCTGCAGGGTCAAAGGATCATGGCAGTGTGCCCATTATTGTACCTTTAATTCCACCACCTTTCATAAAGCCACCAGCAG
AAGATGATGTGTCAAATGTACAAATAATGTGTGCCTGGTGCCAGAAAGTGGGAATCAAGCGCTATTCCCTGAGTATGGGAAGTGAGGTGA
AAAGCTTCTGCAGCGAGAAGTGCTTTGCGGCCTGCCGACGAGCCTACTTCAAGAGAAATAAGGCTAGAGATGAAGATGGACATGCTGAAA
ATTTTCCCCAGCAGCACTATGCTAAGGAAACTCCAAGGCTTGCCTTCAAGAATAACTGCGAACTACTTAATGTGAAACACAGGAAGTATG
CCAGATGGAAGGCAACATACATCCATAATTGTTTAAAGAATGGGGAGACTCCTCAAGCAGGCCCTGTTGGAATTGAAGAAGATAATGATA
TTGAAGAAAATGAAGATGCTGGAGCAGCCTCTCTGCCCACTCAGCCAACTCAGCCATCATCATCTTCAACTTATGACCCAAGCAACATGC
CATCAGGCAACTATACTGGAATACAGATTCCTCCGGGTGCACACGCTCCAGCTAATACACCAGCAGAAGTGCCTCACAGCACAGGTGTAG
CAAGTAATACTATCCAACCTACTCCACAGACTATACCTGCCATTGATCCCGCACTTTTCAATACAATTTCCCAGGGGGATGTTCGTCTAA
CCCCAGAAGACTTTGCTAGAGCTCAGAAGTACTGCAAATATGCTGGCAGTGCTTTGCAGTATGAAGATGTAAGCACTGCTGTCCAGAATC
TACAAAAGGCTCTCAAGTTACTGACGACAGGCAGAGAATGAAGCCTTTGTATGACAGACCCATGTATTTTTGGCATGAGGAACTAACAGT
CCATTACTCTATCTTCAGCCTATCAGGATCACAGTTTTAAGGAAGACTTGGTTTTGTTGAATATGACAATGAAATCTGTGTGTATCAGAT
TTTTATTGAAGCATTCATCAGCAGCCTCAACCAGTTTTCATTGTCCATTTACTAGATTCAATCGTCTCTGAGTATATAGGGCTGATGTTA
GCAAGACCCTAAAAATGTCCATTGAACCCTGCTTCAAAAAATGAAAACACACCTCTATAAAATGTGTACTGGGAATAAGCTTTGTATTTA
CATACATTAGGGGAATTTTTTAAAATCTGTAATGTTTGGACAAACAGATGATATTACTTTGCTATAAAATTATAAATGTAACTTTTAATA

>In-frame_ENST00000317357_ENST00000367621_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(amino acids)=393AA_start in transcript=659_stop in transcript=1840
MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPED
SVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFA
ACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLNVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAA
SLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGVASNTIQPTPQTIPAIDPALFNTISQGDVRLTPEDFARAQK

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>In-frame_ENST00000317357_ENST00000452973_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(transcript)=2368nt_BP=1328nt
AGCCACGCCCGCTCGAGAGCCGGGGGGCTGTCCTCGCCCCCCCCACCTTTCCCCTCCCTCCGACCCCCTCCCGGCCGCGCTCCCTCCCCT
CCTCCCGCGCCGGCCCCCGGCCCGCCCCCGGCTCGGCTCGCGGGAGGCGCTGGGCGCCGGGGCTGGCGCGCTCTCCCGGGCTCACACACA
GCCGCGCACGCACGCCCGGGGCCGCTCTCCGCGCCGGCCCTTGCTCCCCGCGCCCATGCGGACGGACCGAGCGACGGAAGATGGCTGACG
ACTCCACGGGGCCCCGAGGATGCGGCCCGGCGGCGGCGGCGGCGGGAGCGGCAGCGGCAGCGAGGGCGGCAGGGGCAGCGGCAGCAGCGG
CGGCGTTGGCTGCGGCGGCGGCGGCGGCGGCAGCAGGAGCCGGAGCGACGGCGGCGGCATCCCCGAGACTCTCCGCACTATCCTTACCCG
TGACAGCCACTGACGTCCTCCGCCGCTAGAAGAGACCCCGCTTCTCGGCGCCTGCCCTCCCCCTCGCGGCTCGGTCCGGCCCCGCCAGCA
CCGCTACCTCCGCCAGCCTCGCCACCATCAGCACCACCTCCACCGCCGCCGCCGCCGCCACCACCACCGCCGGCGGCGGCAGCAGCCATT
TCATCTCCACAGAAACCAGACACAAAAACATGGCAGAAATGGAGAAAGAAGGGAGACCTCCCGAAAATAAACGGAGCAGGAAGCCGGCTC
ACCCAGTGAAAAGGGAGATCAATGAGGAGATGAAGAACTTTGCAGAAAACACCATGAATGAACTCCTTGGCTGGTATGGCTATGATAAGG
TTGAATTAAAAGATGGTGAGGATATTGAATTCAGGAGCTACCCTACAGATGGGGAGAGCCGGCAGCACATTTCTGTTCTCAAAGAAAATT
CTTTGCCAAAACCAAAATTACCCGAGGACAGTGTTATTTCACCATACAATATAAGCACAGGCTATTCAGGGCTTGCCACTGGAAATGGAC
TCAGTGACTCACCTGCAGGGTCAAAGGATCATGGCAGTGTGCCCATTATTGTACCTTTAATTCCACCACCTTTCATAAAGCCACCAGCAG
AAGATGATGTGTCAAATGTACAAATAATGTGTGCCTGGTGCCAGAAAGTGGGAATCAAGCGCTATTCCCTGAGTATGGGAAGTGAGGTGA
AAAGCTTCTGCAGCGAGAAGTGCTTTGCGGCCTGCCGACGAGCCTACTTCAAGAGAAATAAGGCTAGAGATGAAGATGGACATGCTGAAA
ATTTTCCCCAGCAGCACTATGCTAAGGAAACTCCAAGGCTTGCCTTCAAGAATAACTGCGAACTACTTAATGTGAAACACAGGAAGTATG
CCAGATGGAAGGCAACATACATCCATAATTGTTTAAAGAATGGGGAGACTCCTCAAGCAGGCCCTGTTGGAATTGAAGAAGATAATGATA
TTGAAGAAAATGAAGATGCTGGAGCAGCCTCTCTGCCCACTCAGCCAACTCAGCCATCATCATCTTCAACTTATGACCCAAGCAACATGC
CATCAGGCAACTATACTGGAATACAGATTCCTCCGGGTGCACACGCTCCAGCTAATACACCAGCAGAAGTGCCTCACAGCACAGGGGATG
TTCGTCTAACCCCAGAAGACTTTGCTAGAGCTCAGAAGTACTGCAAATATGCTGGCAGTGCTTTGCAGTATGAAGATGTAAGCACTGCTG
TCCAGAATCTACAAAAGGCTCTCAAGTTACTGACGACAGGCAGAGAATGAAGCCTTTGTATGACAGACCCATGTATTTTTGGCATGAGGA
ACTAACAGTCCATTACTCTATCTTCAGCCTATCAGGATCACAGTTTTAAGGAAGACTTGGTTTTGTTGAATATGACAATGAAATCTGTGT
GTATCAGATTTTTATTGAAGCATTCATCAGCAGCCTCAACCAGTTTTCATTGTCCATTTACTAGATTCAATCGTCTCTGAGTATATAGGG
CTGATGTTAGCAAGACCCTAAAAATGTCCATTGAACCCTGCTTCAAAAAATGAAAACACACCTCTATAAAATGTGTACTGGGAATAAGCT
TTGTATTTACATACATTAGGGGAATTTTTTAAAATCTGTAATGTTTGGACAAACAGATGATATTACTTTGCTATAAAATTATAAATGTAA
CTTTTAATAAAGATAGCCAGAATATTCTAAATTAGAAATTACGTTTTTGTTTCCCTCAAGACATAAAACAAATATAAACATTCTAAACTG
CTGGATGAATCTGAAAAGACATTAAGTTCAAATTTTAATTTATTCTCATATTAAATATAACTCCATTAAAAGTTTAAAATTTCATGGGAG

>In-frame_ENST00000317357_ENST00000452973_TCGA-CC-5261_SOBP_chr6_107908379_+_VTA1_chr6_142510562_length(amino acids)=366AA_start in transcript=659_stop in transcript=1759
MAEMEKEGRPPENKRSRKPAHPVKREINEEMKNFAENTMNELLGWYGYDKVELKDGEDIEFRSYPTDGESRQHISVLKENSLPKPKLPED
SVISPYNISTGYSGLATGNGLSDSPAGSKDHGSVPIIVPLIPPPFIKPPAEDDVSNVQIMCAWCQKVGIKRYSLSMGSEVKSFCSEKCFA
ACRRAYFKRNKARDEDGHAENFPQQHYAKETPRLAFKNNCELLNVKHRKYARWKATYIHNCLKNGETPQAGPVGIEEDNDIEENEDAGAA
SLPTQPTQPSSSSTYDPSNMPSGNYTGIQIPPGAHAPANTPAEVPHSTGDVRLTPEDFARAQKYCKYAGSALQYEDVSTAVQNLQKALKL

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Fusion Gene PPI Analysis for SOBP-VTA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneVTA1chr6:107908379chr6:142510562ENST0000036763038198_307137.0308.0VPS4B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneVTA1chr6:107908379chr6:142510562ENST00000367630382_75137.0308.0CHMP5
TgeneVTA1chr6:107908379chr6:142510562ENST00000367630382_186137.0308.0IST1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOBP-VTA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOBP-VTA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOBPC3150924MENTAL RETARDATION, ANTERIOR MAXILLARY PROTRUSION, AND STRABISMUS2CTD_human;GENOMICS_ENGLAND
HgeneSOBPC0033975Psychotic Disorders1PSYGENET
HgeneSOBPC0349204Nonorganic psychosis1PSYGENET