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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:SORD-IKZF3 (FusionGDB2 ID:84636)

Fusion Gene Summary for SORD-IKZF3

check button Fusion gene summary
Fusion gene informationFusion gene name: SORD-IKZF3
Fusion gene ID: 84636
HgeneTgene
Gene symbol

SORD

IKZF3

Gene ID

6652

22806

Gene namesorbitol dehydrogenaseIKAROS family zinc finger 3
SynonymsHEL-S-95n|RDH|SDH|SORD1|XDHAIO|AIOLOS|ZNFN1A3
Cytomap

15q21.1

17q12-q21.1

Type of geneprotein-codingprotein-coding
Descriptionsorbitol dehydrogenase(R,R)-butanediol dehydrogenaseL-iditol 2-dehydrogenaseepididymis secretory sperm binding protein Li 95npolyol dehydrogenaseribitol dehydrogenasexylitol dehydrogenasezinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)
Modification date2020031320200327
UniProtAcc.

Q9UKT9

Ensembl transtripts involved in fusion geneENST00000267814, ENST00000558580, 
ENST00000559562, 		ENST00000346872, 
ENST00000394189, ENST00000439167, 
ENST00000535189, ENST00000377944, 
ENST00000377945, ENST00000377952, 
ENST00000377958, ENST00000346243, 
ENST00000350532, ENST00000351680, 
ENST00000467757, ENST00000439016, 
ENST00000583368, 
Fusion gene scores* DoF score7 X 4 X 4=11234 X 12 X 14=5712
# samples 949
** MAII scorelog2(9/112*10)=-0.315501825727929
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(49/5712*10)=-3.54314232502653
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORD [Title/Abstract] AND IKZF3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSORD(45335619)-IKZF3(37949186), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORD

GO:0006062

sorbitol catabolic process

3365415|6870831|8487505|12962626

HgeneSORD

GO:0046370

fructose biosynthetic process

3365415|6870831|8487505

HgeneSORD

GO:0051160

L-xylitol catabolic process

8487505

HgeneSORD

GO:0051164

L-xylitol metabolic process

3365415


check buttonFusion gene breakpoints across SORD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IKZF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6822SORDchr15

45335619

+IKZF3chr17

37949186

-
ChimerDB4STADTCGA-D7-6822-01ASORDchr15

45335619

+IKZF3chr17

37949186

-


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Fusion Gene ORF analysis for SORD-IKZF3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267814ENST00000346872SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000394189SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000439167SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000535189SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000377944SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000377945SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000377952SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000377958SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000346243SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000350532SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000351680SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000467757SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000439016SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000267814ENST00000583368SORDchr15

45335619

+IKZF3chr17

37949186

-
In-frameENST00000558580ENST00000346872SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000394189SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000439167SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000535189SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000377944SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000377945SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000377952SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000377958SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000346243SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000350532SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000351680SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000467757SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000439016SORDchr15

45335619

+IKZF3chr17

37949186

-
5CDS-intronENST00000558580ENST00000583368SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-3CDSENST00000559562ENST00000346872SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000394189SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000439167SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000535189SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000377944SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000377945SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000377952SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000377958SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000346243SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000350532SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000351680SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000467757SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000439016SORDchr15

45335619

+IKZF3chr17

37949186

-
intron-intronENST00000559562ENST00000583368SORDchr15

45335619

+IKZF3chr17

37949186

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000267814SORDchr1545335619+ENST00000346872IKZF3chr1737949186-26574451801811543
ENST00000558580SORDchr1545335619+ENST00000346872IKZF3chr1737949186-25203081061674522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000267814ENST00000346872SORDchr1545335619+IKZF3chr1737949186-0.0007751640.9992248
ENST00000558580ENST00000346872SORDchr1545335619+IKZF3chr1737949186-0.0011910880.998809

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Fusion Genomic Features for SORD-IKZF3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SORD-IKZF3


check button Go to

FGviewer for the breakpoints of chr15:45335619-chr17:37949186

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IKZF3

Q9UKT9

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269|PubMed:10369681}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326118_14054.333333333333336432.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326146_16854.333333333333336432.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326174_19654.333333333333336432.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326202_22454.333333333333336432.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326452_47454.333333333333336432.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034624326480_50454.333333333333336432.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228118_14054.333333333333336510.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228146_16854.333333333333336510.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228174_19654.333333333333336510.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228202_22454.333333333333336510.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228452_47454.333333333333336510.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000034687228480_50454.333333333333336510.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227118_14054.333333333333336471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227146_16854.333333333333336471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227174_19654.333333333333336471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227202_22454.333333333333336471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227452_47454.333333333333336471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035053227480_50454.333333333333336471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027118_14054.333333333333336471.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027146_16854.333333333333336471.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027174_19654.333333333333336471.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027202_22454.333333333333336471.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027452_47454.333333333333336471.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000035168027480_50454.333333333333336471.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406118_1400367.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406146_1680367.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406174_1960367.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406202_2240367.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406452_4740367.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794406480_5040367.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525118_14054.333333333333336376.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525146_16854.333333333333336376.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525174_19654.333333333333336376.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525202_22454.333333333333336376.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525452_47454.333333333333336376.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037794525480_50454.333333333333336376.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204118_1400289.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204146_1680289.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204174_1960289.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204202_2240289.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204452_4740289.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795204480_5040289.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807118_1400423.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807146_1680423.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807174_1960423.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807202_2240423.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807452_4740423.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000037795807480_5040423.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905118_1400328.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905146_1680328.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905174_1960328.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905202_2240328.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905452_4740328.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000039418905480_5040328.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626118_14054.333333333333336415.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626146_16854.333333333333336415.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626174_19654.333333333333336415.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626202_22454.333333333333336415.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626452_47454.333333333333336415.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043901626480_50454.333333333333336415.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716118_14020.333333333333332437.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716146_16820.333333333333332437.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716174_19620.333333333333332437.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716202_22420.333333333333332437.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716452_47420.333333333333332437.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000043916716480_50420.333333333333332437.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727118_14054.333333333333336454.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727146_16854.333333333333336454.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727174_19654.333333333333336454.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727202_22454.333333333333336454.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727452_47454.333333333333336454.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000046775727480_50454.333333333333336454.0Zinc fingerC2H2-type 6%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917118_14020.333333333333332476.0Zinc fingerC2H2-type 1
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917146_16820.333333333333332476.0Zinc fingerC2H2-type 2
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917174_19620.333333333333332476.0Zinc fingerC2H2-type 3
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917202_22420.333333333333332476.0Zinc fingerC2H2-type 4%3B atypical
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917452_47420.333333333333332476.0Zinc fingerC2H2-type 5
TgeneIKZF3chr15:45335619chr17:37949186ENST0000053518917480_50420.333333333333332476.0Zinc fingerC2H2-type 6%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORDchr15:45335619chr17:37949186ENST00000267814+39273_27588.33333333333333358.0Nucleotide bindingNAD
HgeneSORDchr15:45335619chr17:37949186ENST00000267814+39297_29988.33333333333333358.0Nucleotide bindingNAD


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Fusion Gene Sequence for SORD-IKZF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000267814_ENST00000346872_TCGA-D7-6822_SORD_chr15_45335619_+_IKZF3_chr17_37949186_length(transcript)=2657nt_BP=445nt
CTCCACGCTAGCGCCGCCCAGGCTGGCACAAAGGAGGAAGCCTAGTCCCGCCCCTGCGTGCGGCGCTTCTCCCAGGCCCCACCTTCCATC
CAGTGCCCTGGACCCTCGGCTGGGTAGCGCCACCAGAGCGACCAAACGTCCCGCGCCTTCCAGGCCGCACTCCAGAGCCAAAAGAGCTCC
ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTGCGCCTGGAGAACTATCCTATCCCTGAACCA
GGCCCAAATGAGGTCTTGCTGAGGATGCATTCTGTTGGAATCTGTGGCTCAGATGTCCACTACTGGGAGTATGGTCGAATTGGGAATTTT
ATTGTGAAAAAGCCCATGGTGCTGGGACATGAAGCTTCGGGAACAGTCGAAAAAGTGGGATCATCGGTAAAGCACCTAAAACCAGATGAT
TCAATGAAAGTGAAAGATGAATACAGTGAAAGAGATGAGAATGTTTTAAAGTCAGAACCCATGGGAAATGCAGAAGAGCCTGAAATCCCT
TACAGCTATTCAAGAGAATATAATGAATATGAAAACATTAAGTTGGAGAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGA
AAGATGAACTGCGATGTGTGTGGATTATCCTGCATCAGCTTCAATGTCTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTC
CAGTGTAATCAGTGTGGGGCATCTTTTACTCAGAAAGGTAACCTCCTCCGCCACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGT
CACCTCTGCAACTATGCATGCCAAAGAAGAGATGCGCTCACGGGGCATCTTAGGACACATTCTGTGGAGAAACCCTACAAATGTGAGTTT
TGTGGAAGGAGTTACAAGCAGAGAAGTTCCCTTGAGGAGCACAAGGAGCGCTGCCGTACATTTCTTCAGAGCACTGACCCAGGGGACACT
GCAAGTGCGGAGGCAAGACACATCAAAGCAGAGATGGGAAGTGAAAGAGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAAAACGA
AAAAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGCGCCACTGCTTTGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGT
GAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCATCAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACA
CCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTATCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCT
CAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCCTTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCC
ACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCAGCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCA
CTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCCCATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGG
GAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCTGGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTC
CGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCGGTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACAGAGCC
CTGCTGAAGTGAATATCTGGTCTCAGGGATTGCTCCTATGTATTCAGCATCGTTTCTAAAAACCAATGACCTCGCCTAACAGATTGCTCT
CAAAACATACTCAGTTCCAAACTTCTTTTCATACCATTTTTAGCTGTGTTCACAGGGGTAGCCAGGGAAACACTGTCTTCCTTCAGAAAT
TATTCGCAGGTCTAGCATATTATTACTTTTGTGAAACCTTTGTTTTCCCATCAGGGACTTGAATTTTATGGAATTTAAAAGCCAAAAAGG
TATTTGGTCATTATCTTCTACAGCAGTGGAATGAGTGGTCCCGGAGATGTGCTATATGAAACATTCTTTCTGAGATATATCAACCACACG
TGGAAAAGCCTTTCAGTCATACATGCAAATCCACAAAGAGGAAGAGCTGACCAGCTGACCTTGCTGGGAAGCCTCACCCTTCTGCCCTTC
ACAGGCTGAAGGGTTAAGATCTAATCTCCCTAATCTAAATGACAGTCTAAGAGTAAGTAAAAGAACAGCCATAAAATAAGTATCTGTTAC
GAGTAACTGAAGACCCCATTCTCCAAGCATCAGATCCATTTCCTATCACAACATTTTTAAAAAATGTCATCTGATGGCACTTCTGCTTCT
GTCCTTTACCTTCCCATCTCCAGTGAAAAGCTGAGCTGCTTTGGGCTAAACCAGTTGTCTATAGAAGAAAATCTATGCCAGAAGAACTCA
TGGTTTTAAATATAGACCATCATCGAAACTCCAGAAATTTATCCACTGTGGATGATGACATCGCTTTCCTTTGGTCAAGGTTGGCAGAGC

>In-frame_ENST00000267814_ENST00000346872_TCGA-D7-6822_SORD_chr15_45335619_+_IKZF3_chr17_37949186_length(amino acids)=543AA_start in transcript=180_stop in transcript=1811
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPDD
SMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPF
QCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDT
ASAEARHIKAEMGSERALVLDRLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQT
PPAPTSEMVPVISSMYPIALTRAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMP
LLKEVPRSYELLKPPPICPRDSVKVINKEGEVMDVYRCDHCRVLFLDYVMFTIHMGCHGFRDPFECNMCGYRSHDRYEFSSHIARGEHRA

--------------------------------------------------------------
>In-frame_ENST00000558580_ENST00000346872_TCGA-D7-6822_SORD_chr15_45335619_+_IKZF3_chr17_37949186_length(transcript)=2520nt_BP=308nt
TGAGACCAAGAACCCACCAATTCCGGACACAAAGAGAGGAGTATATATGTGATTAAGATATGTATTTCTGACTTGAAGTGAAATATTCTG
GAAAACTCACACAACTATGGAGAACTATCCTATCCCTGAACCAGGCCCAAATGAGGTCTTGCTGAGGATGCATTCTGTTGGAATCTGTGG
CTCAGATGTCCACTACTGGGAGTATGGTCGAATTGGGAATTTTATTGTGAAAAAGCCCATGGTGCTGGGACATGAAGCTTCGGGAACAGT
CGAAAAAGTGGGATCATCGGTAAAGCACCTAAAACCAGATGATTCAATGAAAGTGAAAGATGAATACAGTGAAAGAGATGAGAATGTTTT
AAAGTCAGAACCCATGGGAAATGCAGAAGAGCCTGAAATCCCTTACAGCTATTCAAGAGAATATAATGAATATGAAAACATTAAGTTGGA
GAGACATGTTGTCTCATTCGATAGTAGCAGGCCAACCAGTGGAAAGATGAACTGCGATGTGTGTGGATTATCCTGCATCAGCTTCAATGT
CTTAATGGTTCATAAGCGAAGCCATACTGGTGAACGCCCATTCCAGTGTAATCAGTGTGGGGCATCTTTTACTCAGAAAGGTAACCTCCT
CCGCCACATTAAACTGCACACAGGGGAAAAACCTTTTAAGTGTCACCTCTGCAACTATGCATGCCAAAGAAGAGATGCGCTCACGGGGCA
TCTTAGGACACATTCTGTGGAGAAACCCTACAAATGTGAGTTTTGTGGAAGGAGTTACAAGCAGAGAAGTTCCCTTGAGGAGCACAAGGA
GCGCTGCCGTACATTTCTTCAGAGCACTGACCCAGGGGACACTGCAAGTGCGGAGGCAAGACACATCAAAGCAGAGATGGGAAGTGAAAG
AGCTCTCGTACTGGACAGATTAGCAAGCAATGTGGCAAAACGAAAAAGCTCAATGCCTCAGAAATTCATTGGTGAGAAGCGCCACTGCTT
TGATGTCAACTATAATTCAAGTTACATGTATGAGAAAGAGAGTGAGCTCATACAGACCCGCATGATGGACCAAGCCATCAATAACGCCAT
CAGCTATCTTGGCGCCGAAGCCCTGCGCCCCTTGGTCCAGACACCGCCTGCTCCCACCTCGGAGATGGTTCCAGTTATCAGCAGCATGTA
TCCCATAGCCCTCACCCGGGCTGAGATGTCAAACGGTGCCCCTCAAGAGCTGGAAAAGAAAAGCATCCACCTTCCAGAGAAGAGCGTGCC
TTCTGAGAGAGGCCTCTCTCCCAACAATAGTGGCCACGACTCCACGGACACTGACAGCAACCATGAAGAACGCCAGAATCACATCTATCA
GCAAAATCACATGGTCCTGTCTCGGGCCCGCAATGGGATGCCACTTCTGAAGGAGGTTCCCCGCTCTTACGAACTCCTCAAGCCCCCGCC
CATCTGCCCAAGAGACTCCGTCAAAGTGATCAACAAGGAAGGGGAGGTGATGGATGTGTATCGGTGTGACCACTGCCGCGTCCTCTTCCT
GGACTATGTGATGTTCACGATTCACATGGGCTGCCACGGCTTCCGTGACCCTTTCGAGTGTAACATGTGTGGATATCGAAGCCATGATCG
GTATGAGTTCTCGTCTCACATAGCCAGAGGAGAACACAGAGCCCTGCTGAAGTGAATATCTGGTCTCAGGGATTGCTCCTATGTATTCAG
CATCGTTTCTAAAAACCAATGACCTCGCCTAACAGATTGCTCTCAAAACATACTCAGTTCCAAACTTCTTTTCATACCATTTTTAGCTGT
GTTCACAGGGGTAGCCAGGGAAACACTGTCTTCCTTCAGAAATTATTCGCAGGTCTAGCATATTATTACTTTTGTGAAACCTTTGTTTTC
CCATCAGGGACTTGAATTTTATGGAATTTAAAAGCCAAAAAGGTATTTGGTCATTATCTTCTACAGCAGTGGAATGAGTGGTCCCGGAGA
TGTGCTATATGAAACATTCTTTCTGAGATATATCAACCACACGTGGAAAAGCCTTTCAGTCATACATGCAAATCCACAAAGAGGAAGAGC
TGACCAGCTGACCTTGCTGGGAAGCCTCACCCTTCTGCCCTTCACAGGCTGAAGGGTTAAGATCTAATCTCCCTAATCTAAATGACAGTC
TAAGAGTAAGTAAAAGAACAGCCATAAAATAAGTATCTGTTACGAGTAACTGAAGACCCCATTCTCCAAGCATCAGATCCATTTCCTATC
ACAACATTTTTAAAAAATGTCATCTGATGGCACTTCTGCTTCTGTCCTTTACCTTCCCATCTCCAGTGAAAAGCTGAGCTGCTTTGGGCT
AAACCAGTTGTCTATAGAAGAAAATCTATGCCAGAAGAACTCATGGTTTTAAATATAGACCATCATCGAAACTCCAGAAATTTATCCACT
GTGGATGATGACATCGCTTTCCTTTGGTCAAGGTTGGCAGAGCAAGGGTATAAAGGGGGAAATTGTTTGGCAGCACCAACAGAAAACAAA

>In-frame_ENST00000558580_ENST00000346872_TCGA-D7-6822_SORD_chr15_45335619_+_IKZF3_chr17_37949186_length(amino acids)=522AA_start in transcript=106_stop in transcript=1674
MENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPDDSMKVKDEYSERDENVLKSEPM
GNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKL
HTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTASAEARHIKAEMGSERALVLD
RLASNVAKRKSSMPQKFIGEKRHCFDVNYNSSYMYEKESELIQTRMMDQAINNAISYLGAEALRPLVQTPPAPTSEMVPVISSMYPIALT
RAEMSNGAPQELEKKSIHLPEKSVPSERGLSPNNSGHDSTDTDSNHEERQNHIYQQNHMVLSRARNGMPLLKEVPRSYELLKPPPICPRD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SORD-IKZF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SORD-IKZF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SORD-IKZF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORDC0019193Hepatitis, Toxic1CTD_human
HgeneSORDC0027055Myocardial Reperfusion Injury1CTD_human
HgeneSORDC0520459Necrotizing Enterocolitis1CTD_human
HgeneSORDC0860207Drug-Induced Liver Disease1CTD_human
HgeneSORDC1262760Hepatitis, Drug-Induced1CTD_human
HgeneSORDC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneSORDC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneSORDC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneIKZF3C0003873Rheumatoid Arthritis1CTD_human
TgeneIKZF3C0004096Asthma1CTD_human
TgeneIKZF3C0023434Chronic Lymphocytic Leukemia1ORPHANET
TgeneIKZF3C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneIKZF3C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneIKZF3C0855095Small Lymphocytic Lymphoma1ORPHANET
TgeneIKZF3C1868683B-CELL MALIGNANCY, LOW-GRADE1ORPHANET
TgeneIKZF3C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIKZF3C2930967Gastro-enteropancreatic neuroendocrine tumor1CTD_human