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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:SORL1-CEP164 (FusionGDB2 ID:84646)

Fusion Gene Summary for SORL1-CEP164

check button Fusion gene summary
Fusion gene informationFusion gene name: SORL1-CEP164
Fusion gene ID: 84646
HgeneTgene
Gene symbol

SORL1

CEP164

Gene ID

6653

22897

Gene namesortilin related receptor 1centrosomal protein 164
SynonymsC11orf32|LR11|LRP9|SORLA|SorLA-1|gp250NPHP15
Cytomap

11q24.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionsortilin-related receptorLDLR relative with 11 ligand-binding repeatslow-density lipoprotein receptor relative with 11 ligand-binding repeatsmosaic protein LR11sortilin-related receptor, L(DLR class) A repeats containingsorting protein-related receptcentrosomal protein of 164 kDacentrosomal protein 164kDa
Modification date2020032720200320
UniProtAcc.

Q9UPV0

Ensembl transtripts involved in fusion geneENST00000260197, ENST00000532451, 
ENST00000525532, ENST00000532694, 
ENST00000534286, ENST00000527934, 
ENST00000278935, ENST00000533706, 
Fusion gene scores* DoF score17 X 17 X 8=23124 X 5 X 4=80
# samples 235
** MAII scorelog2(23/2312*10)=-3.3294356315563
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORL1 [Title/Abstract] AND CEP164 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSORL1(121367758)-CEP164(117251330), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORL1

GO:0006605

protein targeting

16407538|21385844|27322061

HgeneSORL1

GO:0006622

protein targeting to lysosome

24523320

HgeneSORL1

GO:0006892

post-Golgi vesicle-mediated transport

17855360

HgeneSORL1

GO:0014910

regulation of smooth muscle cell migration

14764453

HgeneSORL1

GO:0032091

negative regulation of protein binding

16407538

HgeneSORL1

GO:0034067

protein localization to Golgi apparatus

17855360

HgeneSORL1

GO:0038020

insulin receptor recycling

27322061

HgeneSORL1

GO:0045053

protein retention in Golgi apparatus

17855360

HgeneSORL1

GO:0045732

positive regulation of protein catabolic process

24523320

HgeneSORL1

GO:0046628

positive regulation of insulin receptor signaling pathway

27322061

HgeneSORL1

GO:0051604

protein maturation

17855360

HgeneSORL1

GO:1900168

positive regulation of glial cell-derived neurotrophic factor secretion

21994944

HgeneSORL1

GO:1902430

negative regulation of amyloid-beta formation

16407538|22621900

HgeneSORL1

GO:1902960

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

16407538

HgeneSORL1

GO:1904179

positive regulation of adipose tissue development

27322061


check buttonFusion gene breakpoints across SORL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CEP164 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-VG-A8LO-01ASORL1chr11

121367758

+CEP164chr11

117251330

+
ChimerDB4OVTCGA-VG-A8LOSORL1chr11

121367758

+CEP164chr11

117251329

+
ChimerDB4OVTCGA-VG-A8LOSORL1chr11

121367758

+CEP164chr11

117251329

+
ChimerDB4OVTCGA-VG-A8LO-01ASORL1chr11

121367758

+CEP164chr11

117251330

+
ChimerDB4OVTCGA-VG-A8LO-01ASORL1chr11

121367758

-CEP164chr11

117251330

+


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Fusion Gene ORF analysis for SORL1-CEP164

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000260197ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
5CDS-3UTRENST00000260197ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
3UTR-3CDSENST00000532451ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
3UTR-3UTRENST00000532451ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3CDSENST00000525532ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3UTRENST00000525532ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3CDSENST00000532694ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3UTRENST00000532694ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3CDSENST00000534286ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3UTRENST00000534286ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3CDSENST00000527934ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251330

+
intron-3UTRENST00000527934ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251330

+
In-frameENST00000260197ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
5CDS-3UTRENST00000260197ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+
3UTR-3CDSENST00000532451ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
3UTR-3UTRENST00000532451ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3CDSENST00000525532ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3UTRENST00000525532ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3CDSENST00000532694ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3UTRENST00000532694ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3CDSENST00000534286ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3UTRENST00000534286ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3CDSENST00000527934ENST00000278935SORL1chr11

121367758

+CEP164chr11

117251329

+
intron-3UTRENST00000527934ENST00000533706SORL1chr11

121367758

+CEP164chr11

117251329

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000260197SORL1chr11121367758+ENST00000278935CEP164chr11117251330+523410686641331355
ENST00000260197SORL1chr11121367758+ENST00000278935CEP164chr11117251329+523410686641331355

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000260197ENST00000278935SORL1chr11121367758+CEP164chr11117251330+0.0082694660.9917305
ENST00000260197ENST00000278935SORL1chr11121367758+CEP164chr11117251329+0.0082694660.9917305

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Fusion Genomic Features for SORL1-CEP164


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SORL1chr11121367758+CEP164chr11117251329+8.56E-091
SORL1chr11121367758+CEP164chr11117251329+8.56E-091
SORL1chr11121367758+CEP164chr11117251329+8.56E-091
SORL1chr11121367758+CEP164chr11117251329+8.56E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SORL1-CEP164


check button Go to

FGviewer for the breakpoints of chr11:121367758-chr11:117251330

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP164

Q9UPV0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. {ECO:0000269|PubMed:17954613, ECO:0000269|PubMed:18283122, ECO:0000269|PubMed:23348840}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+64863_65313.02215.0MotifCell attachment site
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+64863_65313.02215.0MotifCell attachment site
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648136_147313.02215.0RepeatNote=BNR 1
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648232_243313.02215.0RepeatNote=BNR 2
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648136_147313.02215.0RepeatNote=BNR 1
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648232_243313.02215.0RepeatNote=BNR 2
TgeneCEP164chr11:121367758chr11:117251329ENST0000027893510331154_1206439.01461.0Coiled coilOntology_term=ECO:0000255
TgeneCEP164chr11:121367758chr11:117251330ENST0000027893510331154_1206439.01461.0Coiled coilOntology_term=ECO:0000255
TgeneCEP164chr11:121367758chr11:117251329ENST000002789351033468_955439.01461.0Compositional biasNote=Glu-rich
TgeneCEP164chr11:121367758chr11:117251330ENST000002789351033468_955439.01461.0Compositional biasNote=Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481026_1072313.02215.0DomainNote=EGF-like
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481076_1114313.02215.0DomainLDL-receptor class A 1
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481115_1155313.02215.0DomainLDL-receptor class A 2
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481156_1194313.02215.0DomainLDL-receptor class A 3
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481198_1236313.02215.0DomainLDL-receptor class A 4
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481238_1272313.02215.0DomainLDL-receptor class A 5
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481273_1317313.02215.0DomainLDL-receptor class A 6
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481323_1361313.02215.0DomainLDL-receptor class A 7
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481366_1405313.02215.0DomainLDL-receptor class A 8
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481417_1455313.02215.0DomainLDL-receptor class A 9
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481469_1508313.02215.0DomainLDL-receptor class A 10
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481512_1551313.02215.0DomainLDL-receptor class A 11
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481557_1649313.02215.0DomainFibronectin type-III 1
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481653_1745313.02215.0DomainFibronectin type-III 2
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481749_1844313.02215.0DomainFibronectin type-III 3
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481843_1927313.02215.0DomainFibronectin type-III 4
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6481934_2029313.02215.0DomainFibronectin type-III 5
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6482030_2118313.02215.0DomainFibronectin type-III 6
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481026_1072313.02215.0DomainNote=EGF-like
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481076_1114313.02215.0DomainLDL-receptor class A 1
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481115_1155313.02215.0DomainLDL-receptor class A 2
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481156_1194313.02215.0DomainLDL-receptor class A 3
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481198_1236313.02215.0DomainLDL-receptor class A 4
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481238_1272313.02215.0DomainLDL-receptor class A 5
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481273_1317313.02215.0DomainLDL-receptor class A 6
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481323_1361313.02215.0DomainLDL-receptor class A 7
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481366_1405313.02215.0DomainLDL-receptor class A 8
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481417_1455313.02215.0DomainLDL-receptor class A 9
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481469_1508313.02215.0DomainLDL-receptor class A 10
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481512_1551313.02215.0DomainLDL-receptor class A 11
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481557_1649313.02215.0DomainFibronectin type-III 1
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481653_1745313.02215.0DomainFibronectin type-III 2
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481749_1844313.02215.0DomainFibronectin type-III 3
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481843_1927313.02215.0DomainFibronectin type-III 4
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6481934_2029313.02215.0DomainFibronectin type-III 5
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6482030_2118313.02215.0DomainFibronectin type-III 6
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6482161_2164313.02215.0MotifPotential nuclear localization signal for the C-terminal fragment generated by PSEN1
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6482161_2164313.02215.0MotifPotential nuclear localization signal for the C-terminal fragment generated by PSEN1
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648441_452313.02215.0RepeatNote=BNR 3
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648521_532313.02215.0RepeatNote=BNR 4
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648562_573313.02215.0RepeatNote=BNR 5
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648800_843313.02215.0RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648844_887313.02215.0RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648888_932313.02215.0RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648933_970313.02215.0RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+648971_1013313.02215.0RepeatNote=LDL-receptor class B 5
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648441_452313.02215.0RepeatNote=BNR 3
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648521_532313.02215.0RepeatNote=BNR 4
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648562_573313.02215.0RepeatNote=BNR 5
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648800_843313.02215.0RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648844_887313.02215.0RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648888_932313.02215.0RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648933_970313.02215.0RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+648971_1013313.02215.0RepeatNote=LDL-receptor class B 5
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6482159_2214313.02215.0Topological domainCytoplasmic
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+64882_2137313.02215.0Topological domainLumenal
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6482159_2214313.02215.0Topological domainCytoplasmic
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+64882_2137313.02215.0Topological domainLumenal
HgeneSORL1chr11:121367758chr11:117251329ENST00000260197+6482138_2158313.02215.0TransmembraneHelical
HgeneSORL1chr11:121367758chr11:117251330ENST00000260197+6482138_2158313.02215.0TransmembraneHelical
TgeneCEP164chr11:121367758chr11:117251329ENST000002789351033110_122439.01461.0Compositional biasNote=Lys-rich
TgeneCEP164chr11:121367758chr11:117251330ENST000002789351033110_122439.01461.0Compositional biasNote=Lys-rich
TgeneCEP164chr11:121367758chr11:117251329ENST00000278935103356_89439.01461.0DomainWW
TgeneCEP164chr11:121367758chr11:117251330ENST00000278935103356_89439.01461.0DomainWW


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Fusion Gene Sequence for SORL1-CEP164


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000260197_ENST00000278935_TCGA-VG-A8LO-01A_SORL1_chr11_121367758_+_CEP164_chr11_117251330_length(transcript)=5234nt_BP=1068nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGGCCCAGCAACCA
CTGGGAATAGAAGACAAGGATGACAGCCAGTCCAGCCAAGATGAGCTGCAGAGCAAGCAGTCCAAAGGCCTGGAGGAGAGGTTATCTCCT
CCACTTCCACACGAGGAGCGGGCCCAGAGTCCCCCTCGCAGCCTGGCCACTGAAGAAGAGCCTCCCCAGGGCCCCGAGGGGCAGCCCGAG
TGGAAGGAGGCAGAGGAGCTTGGGGAGGACTCTGCAGCCAGCCTCAGCCTGCAGCTGTCCCTCCAGAGGGAGCAGGCCCCAAGCCCACCT
GCTGCCTGTGAGAAGGGCAAGGAGCAGCATTCCCAGGCCGAGGAGCTGGGCCCTGGGCAGGAAGAGGCAGAGGATCCTGAGGAGAAGGTG
GCGGTCAGCCCCACCCCGCCAGTCTCTCCAGAGGTGCGATCCACAGAGCCTGTGGCTCCCCCAGAGCAGCTCTCAGAGGCTGCACTAAAG
GCCATGGAAGAGGCAGTGGCCCAAGTACTCGAGCAAGACCAGAGGCACCTGCTGGAATCCAAGCAAGAGAAGATGCAGCAACTGCGGGAG
AAGCTGTGCCAAGAGGAGGAAGAGGAGATCCTCCGGCTTCACCAGCAGAAAGAGCAATCTCTCAGTTCCTTGAGGGAGCGGCTGCAGAAA
GCCATTGAGGAGGAGGAGGCCCGGATGAGAGAGGAGGAAAGCCAGAGGCTATCCTGGCTCCGAGCTCAGGTCCAGTCCAGCACACAAGCA
GATGAGGACCAAATCAGGGCTGAGCAAGAGGCTTCCCTGCAGAAACTGAGAGAAGAGTTGGAGTCTCAACAGAAGGCTGAGAGGGCCAGC
TTGGAACAGAAAAATAGGCAAATGCTGGAGCAGCTCAAGGAAGAGATAGAGGCTTCGGAGAAGAGCGAGCAGGCTGCCCTGAATGCTGCA
AAGGAGAAGGCTCTGCAGCAGCTGAGGGAGCAGCTGGAAGGGGAGAGGAAAGAAGCTGTGGCAACGCTGGAGAAGGAGCACAGTGCTGAG
CTGGAGCGGCTCTGCTCCTCATTGGAGGCCAAGCACCGGGAGGTGGTCTCCAGCCTCCAGAAGAAGATACAGGAAGCTCAACAGAAAGAG
GAGGCCCAGCTGCAGAAGTGCCTTGGGCAAGTGGAGCACAGAGTTCACCAGAAGTCTTATCACGTGGCTGGGTATGAGCACGAGCTCAGC
AGTCTCCTGCGAGAGAAGCGCCAGGAAGTGGAAGGGGAGCATGAGAGGAGGTTGGACAAGATGAAGGAGGAGCACCAGCAAGTGATGGCT
AAGGCCAGAGAGCAGTATGAAGCTGAGGAGAGGAAGCAGCGGGCTGAGCTTCTGGGGCACCTGACCGGAGAGCTGGAGCGCCTGCAGAGG
GCCCATGAACGAGAACTGGAGACTGTGAGGCAGGAGCAACACAAGCGTCTTGAGGACTTGCGGCGCCGGCACAGGGAGCAGGAAAGGAAG
CTCCAGGATTTAGAGTTGGACCTTGAAACCAGAGCTAAAGATGTCAAGGCCAGATTGGCTCTGCTGGAGGTCCAGGAGGAGACCGCCCGG
AGGGAGAAGCAGCAGCTGCTTGATGTGCAGAGGCAGGTTGCTCTGAAGAGTGAGGAAGCCACAGCCACCCATCAGCAGCTGGAGGAGGCA
CAGAAGGAGCACACCCACCTGTTGCAGTCAAACCAGCAGCTCCGAGAAATTCTTGATGAGCTGCAGGCCCGCAAGCTGAAGCTGGAGTCC
CAAGTGGATCTGCTGCAGGCTCAGAGCCAGCAACTGCAGAAACACTTCAGCAGCCTGGAGGCTGAAGCTCAAAAGAAGCAGCACCTGTTG
AGAGAAGTGACAGTTGAGGAAAATAATGCTTCCCCACATTTTGAGCCAGATCTCCATATTGAGGACCTGAGGAAATCCCTTGGAACAAAC
CAGACCAAAGAGGTGTCTTCTTCTCTCTCCCAGAGCAAGGAGGACTTATACTTGGACAGCCTGTCCTCCCACAATGTCTGGCACCTCCTC
TCTGCTGAGGGGGTAGCCCTCCGTAGTGCCAAGGAGTTCCTTGTGCAGCAGACACGCTCCATGCGGAGGCGGCAGACAGCTCTGAAAGCT
GCCCAGCAGCATTGGCGCCATGAGCTGGCCAGTGCGCAGGAGGTGGCCAAAGACCCACCAGGCATCAAGGCCCTGGAAGATATGCGCAAG
AACCTGGAGAAGGAGACCAGGCACCTGGATGAGATGAAGTCGGCCATGCGGAAAGGCCACAACCTGCTGAAGAAGAAAGAGGAGAAGCTG
AATCAGTTGGAGTCCTCTCTTTGGGAAGAGGCCTCAGATGAGGGCACTCTGGGAGGATCCCCCACCAAGAAGGCAGTAACCTTCGACCTC
AGTGACATGGACAGCCTGAGCAGTGAAAGTTCTGAATCTTTTTCCCCGCCTCACCGTGAGTGGTGGCGGCAGCAGAGGATCGACTCAACC
CCGAGTCTCACCTCCCGCAAGATCCACGGGCTTAGCCACTCCCTCCGGCAGATCAGCAGCCAGCTGAGCAGTGTCCTCAGCATCCTGGAC
AGCCTCAACCCTCAGTCGCCGCCGCCGCTCCTCGCCTCCATGCCAGCCCAGCTCCCTCCCCGGGACCCTAAGAGCACCCCCACCCCCACC
TACTATGGCTCCCTGGCCAGGTTCTCAGCCTTATCATCTGCTACACCCACGTCCACCCAATGGGCCTGGGATTCAGGGCAGGGGCCCAGG
CTCCCCTCCTCTGTGGCTCAAACGGTGGACGACTTCCTGTTGGAGAAGTGGCGCAAGTATTTTCCATCTGGCATCCCGCTGCTCAGCAAC
AGCCCCACCCCGCTGGAGAGCAGGCTGGGTTACATGTCTGCCAGTGAGCAGCTCCGGCTCCTACAGCACTCCCATTCGCAAGTCCCTGAG
GCGGGCAGCACCACCTTTCAGGGCATAATTGAGGCCAACCGGAGGTGGCTGGAACGTGTCAAGAATGACCCCAGGTTACCTCTCTTCTCG
TCAACACCCAAGCCAAAAGCTACTTTGAGCCTCCTGCAGCTGGGCCTTGATGAGCACAACAGAGTGAAGGTGTATCGCTTCTGAGGCCCT
GAGCAGGGGCTTGGGGCAGCCCAGCCTCTCCTCCACCCAGACCAAGTGCCTGAGGAGCTGCCTGCCTTCTTCCATCTGAGAAAGCACCCT
CCTTCCCCCTTTGACTTGCAGGAGCCACCAGGGACCAGGGGGTTGAGTGGAACAGTAAAGCCACACATTCTGTGACTATATAACCTATCT
CAGGCTAAAATGTGTGGACTCGTACGAGCTCTTGTCATTGACATGGCAAGCTGATGGCGTGCGGTGGCTGCGGGGTATCAGGGCCGGGAG
CCCTTTGGGAGGAAGGGAGGCGTTAGAGGAGCTGCCTTCGGAGGCTCAGGGAGTCCCTTTGGAGCTGGTTGTTTCCTTGGCCCTGCAGCG
CACTGCTCGGGGCTCCCAAGGAGGTTGTGTGTATGGTTCTTAATTCATCAGGACAAAGACCCCCAGCATGTGTGTACCCTGGGACCCGAT
TTCTCTGGGCCCACATCTATCTCCAATACCTCAGCCTCAGATCAGACCCTTTCTTTTTTGTCTTTCTTCTCTTAATTTTTAAATGCCTCT
TTTCTTGAGCATTCCATCTCTCTTTTTGACCCTCTCAGGACTGGGCTTAGCTGTCCAGAGCCCTGCCGGAGGGTGCTGGGGGCTGTCCCT
CTGCAGGCACTGTGTTTTCCTCAGGGGCTGTCCTCAGAACACCCCTCCTGCTCCCTGGGGCTCCTCAGGGAGCCATTTCAGCTGGAGTCT
CAGGTCTCAAAAACAACTTCTCCAGGAGGCCAAAAAAAGACTGGGTTGGCTTCTGGTCCTCATGATGGCTTTTATCCTCCTGGGACACTT
TGGGTATATTCATGGGCATTGTTTCCATCTGTCTTTTCTACCTGTGCCACCCCTGCCCTGATTCCACGGCTGCCTCAGGCAGGCAGGCAA
GGAGCTAGGCCGGTGCCCGGCCCTGGCAGCAAGGGGTCTTTGTGCAGTTGGAGATGCTGCCGTTGTGGCAGAGCGTCCTGCAGCCCCGCT
TCCATCAGCAGGCTCTGGGGTGGGGGCTTTGCAGGGGATGCTCTCTGATGTTTGTTCCGTTGTTTAAATAAAATGCACTTATTTTTGTTT

>In-frame_ENST00000260197_ENST00000278935_TCGA-VG-A8LO-01A_SORL1_chr11_121367758_+_CEP164_chr11_117251330_length(amino acids)=1355AA_start in transcript=66_stop in transcript=4133
MASRCTFSPGGGATCSSVRPNMATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGA
SRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNR
SEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVK
SFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVAQQPLGIEDKDDSQSSQDELQSKQSK
GLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEE
AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLS
SLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKS
EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV
AGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRR
RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ
ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLS
SHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNL
LKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQL
SSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLARFSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFP
SGIPLLSNSPTPLESRLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKATLSLLQLGLDEHNRV

--------------------------------------------------------------
>In-frame_ENST00000260197_ENST00000278935_TCGA-VG-A8LO_SORL1_chr11_121367758_+_CEP164_chr11_117251329_length(transcript)=5234nt_BP=1068nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGGCCCAGCAACCA
CTGGGAATAGAAGACAAGGATGACAGCCAGTCCAGCCAAGATGAGCTGCAGAGCAAGCAGTCCAAAGGCCTGGAGGAGAGGTTATCTCCT
CCACTTCCACACGAGGAGCGGGCCCAGAGTCCCCCTCGCAGCCTGGCCACTGAAGAAGAGCCTCCCCAGGGCCCCGAGGGGCAGCCCGAG
TGGAAGGAGGCAGAGGAGCTTGGGGAGGACTCTGCAGCCAGCCTCAGCCTGCAGCTGTCCCTCCAGAGGGAGCAGGCCCCAAGCCCACCT
GCTGCCTGTGAGAAGGGCAAGGAGCAGCATTCCCAGGCCGAGGAGCTGGGCCCTGGGCAGGAAGAGGCAGAGGATCCTGAGGAGAAGGTG
GCGGTCAGCCCCACCCCGCCAGTCTCTCCAGAGGTGCGATCCACAGAGCCTGTGGCTCCCCCAGAGCAGCTCTCAGAGGCTGCACTAAAG
GCCATGGAAGAGGCAGTGGCCCAAGTACTCGAGCAAGACCAGAGGCACCTGCTGGAATCCAAGCAAGAGAAGATGCAGCAACTGCGGGAG
AAGCTGTGCCAAGAGGAGGAAGAGGAGATCCTCCGGCTTCACCAGCAGAAAGAGCAATCTCTCAGTTCCTTGAGGGAGCGGCTGCAGAAA
GCCATTGAGGAGGAGGAGGCCCGGATGAGAGAGGAGGAAAGCCAGAGGCTATCCTGGCTCCGAGCTCAGGTCCAGTCCAGCACACAAGCA
GATGAGGACCAAATCAGGGCTGAGCAAGAGGCTTCCCTGCAGAAACTGAGAGAAGAGTTGGAGTCTCAACAGAAGGCTGAGAGGGCCAGC
TTGGAACAGAAAAATAGGCAAATGCTGGAGCAGCTCAAGGAAGAGATAGAGGCTTCGGAGAAGAGCGAGCAGGCTGCCCTGAATGCTGCA
AAGGAGAAGGCTCTGCAGCAGCTGAGGGAGCAGCTGGAAGGGGAGAGGAAAGAAGCTGTGGCAACGCTGGAGAAGGAGCACAGTGCTGAG
CTGGAGCGGCTCTGCTCCTCATTGGAGGCCAAGCACCGGGAGGTGGTCTCCAGCCTCCAGAAGAAGATACAGGAAGCTCAACAGAAAGAG
GAGGCCCAGCTGCAGAAGTGCCTTGGGCAAGTGGAGCACAGAGTTCACCAGAAGTCTTATCACGTGGCTGGGTATGAGCACGAGCTCAGC
AGTCTCCTGCGAGAGAAGCGCCAGGAAGTGGAAGGGGAGCATGAGAGGAGGTTGGACAAGATGAAGGAGGAGCACCAGCAAGTGATGGCT
AAGGCCAGAGAGCAGTATGAAGCTGAGGAGAGGAAGCAGCGGGCTGAGCTTCTGGGGCACCTGACCGGAGAGCTGGAGCGCCTGCAGAGG
GCCCATGAACGAGAACTGGAGACTGTGAGGCAGGAGCAACACAAGCGTCTTGAGGACTTGCGGCGCCGGCACAGGGAGCAGGAAAGGAAG
CTCCAGGATTTAGAGTTGGACCTTGAAACCAGAGCTAAAGATGTCAAGGCCAGATTGGCTCTGCTGGAGGTCCAGGAGGAGACCGCCCGG
AGGGAGAAGCAGCAGCTGCTTGATGTGCAGAGGCAGGTTGCTCTGAAGAGTGAGGAAGCCACAGCCACCCATCAGCAGCTGGAGGAGGCA
CAGAAGGAGCACACCCACCTGTTGCAGTCAAACCAGCAGCTCCGAGAAATTCTTGATGAGCTGCAGGCCCGCAAGCTGAAGCTGGAGTCC
CAAGTGGATCTGCTGCAGGCTCAGAGCCAGCAACTGCAGAAACACTTCAGCAGCCTGGAGGCTGAAGCTCAAAAGAAGCAGCACCTGTTG
AGAGAAGTGACAGTTGAGGAAAATAATGCTTCCCCACATTTTGAGCCAGATCTCCATATTGAGGACCTGAGGAAATCCCTTGGAACAAAC
CAGACCAAAGAGGTGTCTTCTTCTCTCTCCCAGAGCAAGGAGGACTTATACTTGGACAGCCTGTCCTCCCACAATGTCTGGCACCTCCTC
TCTGCTGAGGGGGTAGCCCTCCGTAGTGCCAAGGAGTTCCTTGTGCAGCAGACACGCTCCATGCGGAGGCGGCAGACAGCTCTGAAAGCT
GCCCAGCAGCATTGGCGCCATGAGCTGGCCAGTGCGCAGGAGGTGGCCAAAGACCCACCAGGCATCAAGGCCCTGGAAGATATGCGCAAG
AACCTGGAGAAGGAGACCAGGCACCTGGATGAGATGAAGTCGGCCATGCGGAAAGGCCACAACCTGCTGAAGAAGAAAGAGGAGAAGCTG
AATCAGTTGGAGTCCTCTCTTTGGGAAGAGGCCTCAGATGAGGGCACTCTGGGAGGATCCCCCACCAAGAAGGCAGTAACCTTCGACCTC
AGTGACATGGACAGCCTGAGCAGTGAAAGTTCTGAATCTTTTTCCCCGCCTCACCGTGAGTGGTGGCGGCAGCAGAGGATCGACTCAACC
CCGAGTCTCACCTCCCGCAAGATCCACGGGCTTAGCCACTCCCTCCGGCAGATCAGCAGCCAGCTGAGCAGTGTCCTCAGCATCCTGGAC
AGCCTCAACCCTCAGTCGCCGCCGCCGCTCCTCGCCTCCATGCCAGCCCAGCTCCCTCCCCGGGACCCTAAGAGCACCCCCACCCCCACC
TACTATGGCTCCCTGGCCAGGTTCTCAGCCTTATCATCTGCTACACCCACGTCCACCCAATGGGCCTGGGATTCAGGGCAGGGGCCCAGG
CTCCCCTCCTCTGTGGCTCAAACGGTGGACGACTTCCTGTTGGAGAAGTGGCGCAAGTATTTTCCATCTGGCATCCCGCTGCTCAGCAAC
AGCCCCACCCCGCTGGAGAGCAGGCTGGGTTACATGTCTGCCAGTGAGCAGCTCCGGCTCCTACAGCACTCCCATTCGCAAGTCCCTGAG
GCGGGCAGCACCACCTTTCAGGGCATAATTGAGGCCAACCGGAGGTGGCTGGAACGTGTCAAGAATGACCCCAGGTTACCTCTCTTCTCG
TCAACACCCAAGCCAAAAGCTACTTTGAGCCTCCTGCAGCTGGGCCTTGATGAGCACAACAGAGTGAAGGTGTATCGCTTCTGAGGCCCT
GAGCAGGGGCTTGGGGCAGCCCAGCCTCTCCTCCACCCAGACCAAGTGCCTGAGGAGCTGCCTGCCTTCTTCCATCTGAGAAAGCACCCT
CCTTCCCCCTTTGACTTGCAGGAGCCACCAGGGACCAGGGGGTTGAGTGGAACAGTAAAGCCACACATTCTGTGACTATATAACCTATCT
CAGGCTAAAATGTGTGGACTCGTACGAGCTCTTGTCATTGACATGGCAAGCTGATGGCGTGCGGTGGCTGCGGGGTATCAGGGCCGGGAG
CCCTTTGGGAGGAAGGGAGGCGTTAGAGGAGCTGCCTTCGGAGGCTCAGGGAGTCCCTTTGGAGCTGGTTGTTTCCTTGGCCCTGCAGCG
CACTGCTCGGGGCTCCCAAGGAGGTTGTGTGTATGGTTCTTAATTCATCAGGACAAAGACCCCCAGCATGTGTGTACCCTGGGACCCGAT
TTCTCTGGGCCCACATCTATCTCCAATACCTCAGCCTCAGATCAGACCCTTTCTTTTTTGTCTTTCTTCTCTTAATTTTTAAATGCCTCT
TTTCTTGAGCATTCCATCTCTCTTTTTGACCCTCTCAGGACTGGGCTTAGCTGTCCAGAGCCCTGCCGGAGGGTGCTGGGGGCTGTCCCT
CTGCAGGCACTGTGTTTTCCTCAGGGGCTGTCCTCAGAACACCCCTCCTGCTCCCTGGGGCTCCTCAGGGAGCCATTTCAGCTGGAGTCT
CAGGTCTCAAAAACAACTTCTCCAGGAGGCCAAAAAAAGACTGGGTTGGCTTCTGGTCCTCATGATGGCTTTTATCCTCCTGGGACACTT
TGGGTATATTCATGGGCATTGTTTCCATCTGTCTTTTCTACCTGTGCCACCCCTGCCCTGATTCCACGGCTGCCTCAGGCAGGCAGGCAA
GGAGCTAGGCCGGTGCCCGGCCCTGGCAGCAAGGGGTCTTTGTGCAGTTGGAGATGCTGCCGTTGTGGCAGAGCGTCCTGCAGCCCCGCT
TCCATCAGCAGGCTCTGGGGTGGGGGCTTTGCAGGGGATGCTCTCTGATGTTTGTTCCGTTGTTTAAATAAAATGCACTTATTTTTGTTT

>In-frame_ENST00000260197_ENST00000278935_TCGA-VG-A8LO_SORL1_chr11_121367758_+_CEP164_chr11_117251329_length(amino acids)=1355AA_start in transcript=66_stop in transcript=4133
MASRCTFSPGGGATCSSVRPNMATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGA
SRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNR
SEAVIAQFYHSPADNKRYIFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVK
SFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVAQQPLGIEDKDDSQSSQDELQSKQSK
GLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEE
AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLS
SLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKS
EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV
AGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRR
RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ
ARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLS
SHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNL
LKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQL
SSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLARFSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFP
SGIPLLSNSPTPLESRLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKATLSLLQLGLDEHNRV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SORL1-CEP164


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneCEP164chr11:121367758chr11:117251329ENST0000027893510331_194439.01461.0ATRIP
TgeneCEP164chr11:121367758chr11:117251330ENST0000027893510331_194439.01461.0ATRIP


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SORL1-CEP164


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SORL1-CEP164


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORL1C0002395Alzheimer's Disease4UNIPROT
HgeneSORL1C0004238Atrial Fibrillation1CTD_human
HgeneSORL1C0008370Cholestasis1CTD_human
HgeneSORL1C0019193Hepatitis, Toxic1CTD_human
HgeneSORL1C0027626Neoplasm Invasiveness1CTD_human
HgeneSORL1C0234985Mental deterioration1CTD_human
HgeneSORL1C0235480Paroxysmal atrial fibrillation1CTD_human
HgeneSORL1C0276496Familial Alzheimer Disease (FAD)1ORPHANET
HgeneSORL1C0338656Impaired cognition1CTD_human
HgeneSORL1C0860207Drug-Induced Liver Disease1CTD_human
HgeneSORL1C1262760Hepatitis, Drug-Induced1CTD_human
HgeneSORL1C1270972Mild cognitive disorder1CTD_human
HgeneSORL1C2585653Persistent atrial fibrillation1CTD_human
HgeneSORL1C3468561familial atrial fibrillation1CTD_human
HgeneSORL1C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneSORL1C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneSORL1C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneCEP164C0403553Renal dysplasia and retinal aplasia (disorder)1GENOMICS_ENGLAND;ORPHANET
TgeneCEP164C3541853NEPHRONOPHTHISIS 151CTD_human;GENOMICS_ENGLAND;UNIPROT