|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SOS1-CMTM6 (FusionGDB2 ID:84672) |
Fusion Gene Summary for SOS1-CMTM6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SOS1-CMTM6 | Fusion gene ID: 84672 | Hgene | Tgene | Gene symbol | SOS1 | CMTM6 | Gene ID | 6654 | 54918 |
| Gene name | SOS Ras/Rac guanine nucleotide exchange factor 1 | CKLF like MARVEL transmembrane domain containing 6 | |
| Synonyms | GF1|GGF1|GINGF|HGF|NS4|SOS-1 | CKLFSF6|PRO2219 | |
| Cytomap | 2p22.1 | 3p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | son of sevenless homolog 1gingival fibromatosis, hereditary, 1guanine nucleotide exchange factor | CKLF-like MARVEL transmembrane domain-containing protein 6chemokine-like factor super family 6chemokine-like factor superfamily 6chemokine-like factor superfamily member 6 | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | . | Q9NX76 | |
| Ensembl transtripts involved in fusion gene | ENST00000426016, ENST00000402219, ENST00000395038, ENST00000428721, ENST00000472480, | ENST00000205636, | |
| Fusion gene scores | * DoF score | 9 X 12 X 9=972 | 6 X 6 X 4=144 |
| # samples | 14 | 7 | |
| ** MAII score | log2(14/972*10)=-2.79552948666081 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SOS1 [Title/Abstract] AND CMTM6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SOS1(39347476)-CMTM6(32533378), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | SOS1-CMTM6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across SOS1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CMTM6 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-61-2016 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
Top |
Fusion Gene ORF analysis for SOS1-CMTM6 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000426016 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
| In-frame | ENST00000402219 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
| In-frame | ENST00000395038 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
| intron-3CDS | ENST00000428721 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
| intron-3CDS | ENST00000472480 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000402219 | SOS1 | chr2 | 39347476 | - | ENST00000205636 | CMTM6 | chr3 | 32533378 | - | 3190 | 128 | 41 | 541 | 166 |
| ENST00000395038 | SOS1 | chr2 | 39347476 | - | ENST00000205636 | CMTM6 | chr3 | 32533378 | - | 3177 | 115 | 28 | 528 | 166 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000402219 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - | 0.011133967 | 0.98886603 |
| ENST00000395038 | ENST00000205636 | SOS1 | chr2 | 39347476 | - | CMTM6 | chr3 | 32533378 | - | 0.011303555 | 0.98869646 |
Top |
Fusion Genomic Features for SOS1-CMTM6 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for SOS1-CMTM6 |
| Go to FGviewer for the breakpoints of chr2:39347476-chr3:32533378 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CMTM6 |
| FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy. {ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 128_134 | 46.0 | 184.0 | Topological domain | Extracellular | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 156_183 | 46.0 | 184.0 | Topological domain | Cytoplasmic | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 61_67 | 46.0 | 184.0 | Topological domain | Extracellular | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 89_106 | 46.0 | 184.0 | Topological domain | Cytoplasmic | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 107_127 | 46.0 | 184.0 | Transmembrane | Helical | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 135_155 | 46.0 | 184.0 | Transmembrane | Helical | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 68_88 | 46.0 | 184.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000402219 | - | 1 | 23 | 1258_1261 | 29.0 | 1334.0 | Compositional bias | Note=Poly-Pro |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000426016 | - | 2 | 24 | 1258_1261 | 29.0 | 1334.0 | Compositional bias | Note=Poly-Pro |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000402219 | - | 1 | 23 | 200_390 | 29.0 | 1334.0 | Domain | DH |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000402219 | - | 1 | 23 | 444_548 | 29.0 | 1334.0 | Domain | PH |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000402219 | - | 1 | 23 | 597_741 | 29.0 | 1334.0 | Domain | N-terminal Ras-GEF |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000402219 | - | 1 | 23 | 780_1019 | 29.0 | 1334.0 | Domain | Ras-GEF |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000426016 | - | 2 | 24 | 200_390 | 29.0 | 1334.0 | Domain | DH |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000426016 | - | 2 | 24 | 444_548 | 29.0 | 1334.0 | Domain | PH |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000426016 | - | 2 | 24 | 597_741 | 29.0 | 1334.0 | Domain | N-terminal Ras-GEF |
| Hgene | SOS1 | chr2:39347476 | chr3:32533378 | ENST00000426016 | - | 2 | 24 | 780_1019 | 29.0 | 1334.0 | Domain | Ras-GEF |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 33_160 | 46.0 | 184.0 | Domain | MARVEL | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 1_39 | 46.0 | 184.0 | Topological domain | Cytoplasmic | |
| Tgene | CMTM6 | chr2:39347476 | chr3:32533378 | ENST00000205636 | 0 | 4 | 40_60 | 46.0 | 184.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for SOS1-CMTM6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >In-frame_ENST00000402219_ENST00000205636_TCGA-61-2016_SOS1_chr2_39347476_-_CMTM6_chr3_32533378_length(transcript)=3190nt_BP=128nt CCGCCGCCCCTCTCCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGC CCAAGTGGCGGGGACTACTGGTGCCTGCGCTGAAAAAGTTGCTGTCTCTGCTGGCCTTCATCTGTGAAGAAGTTGTATCACAATGTACTT TATGTGGAGGACTTTATTTTTTTGAGTTTGTAAGCTGCAGTGCCTTTCTTCTGAGTCTCCTTATACTGATTGTGTATTGCACTCCATTTT ATGAGAGAGTTGATACCACAAAAGTAAAATCATCGGATTTTTATATTACTTTGGGAACAGGATGTGTGTTTTTGTTGGCATCCATCATTT TTGTTTCCACACATGACAGGACTTCAGCTGAGATTGCTGCAATTGTGTTTGGATTTATAGCAAGTTTTATGTTCCTACTTGACTTTATCA CTATGCTGTATGAAAAACGACAGGAGTCCCAGCTGAGAAAACCTGAAAATACCACTAGGGCTGAAGCCCTCACTGAGCCACTTAATGCCT AAAGACTCTGGGGAGCAGATGTTACCTAAGGTAGTGACCCTGCATTGTGGTGCCTGAGCCCTGGCAGAAGCTCTTGTAAAATTTGTTAAT TGTTTAAACCACTTCTTTTGGAGAGCAAGGGGAAGGTCAAGAAGGCAGTTTTATCAATATTGTGTCAGTCACCACAAAGTAGGCCAGATA AGTTAAAAAAAATTTTTTTTTAAATAATAATTGAAACTTATCTCAAATGGAGATTTTGGTGGGAGGAGGAGAAAACAATTGTTTTTAAAT CACACAGCTCAACGGTTGATAAATGATTCTGTCATTCTGTTACAGGTCATTCTTTTACTAGGCTTAGCTTCCAAATTATGCTTTATAGCT GTATAAACATCGTGATTATATTCATCTACTTAGAAATTGTTTTATTTTTAAATTAATTTGCTTAGCTGTTTGTTTTGATGCTTAGATTAT GTTCTGTTAATGGGAATTTAACATATTTAAGAAACCAATATTTAAAATGTTGGTCTAGGTTTTTTTCCTTAACATATATTACCAGGCTTT ACTGTATTTCACTCAGCCTTAAATGTTATAATATTTTTGGATAACGGTTATTAATTCTTTGAGACCTTCGTATAGCCTATAAAATGTATG GGAGATGTTGGTATTTTATGTGTATAAAAGCAACAATATCAGCAACTTCGTGTTTATACTGCACCTTGGTTGTTGATGTCAAGTAAAAAA AAGATTGTTTTGTAACACATAAAAAAATGGAAGAAACTGATACCACACCTAAGGACCAAAGATAAGAAAGACTTTTTGCCCAAGACAGTG AAAGTAATTATAAAAACAAGCTTTGACCACTTACCAAGTATCTGAAGAGATGAGTTCATACTATGATTTAGAAAGTGGTTCAATTCCCCT GTTGGCATATGATTATTTTTACTAAAATTAATACAGCTCTGTGGGTCTTCCTTAGTGTTTTCTTTGAAGCCAATCTGTTTTTTTTAGGAC ACCAGCCTTTGGTTTTTCATCTGTTCGAGATGCCTCTTCTCTGTCTCCTTATCAGATAGAAATGGAGTCATGTGCTGCTGCTTCATCTAG CAGAGGTTGGCCTCTGGCTCTGACACTTTTTGTCAGTTGTCTTTAGGTGGTCCTGAATCTTGGGCCCTTTTGATTGTGAATACTGTGTAG CAGGATCTTGAGAGTCCTTGTTCTTACATAGGCATTGCTCTAGTTTGTCTTTGGCAAAAAAAAAAAAAAAAAAAAGTAAATATCCAGGGA ACCCTGCCCAGACTAATACTGTTGGTGGCATAAGAGAATCAAGCCATTCTCAAGAGATAACTTCATAACCAGAATTGTCTGTTGGCTAGC AGCTGTCACAGATAGGCAGGGCACTTGGGATATGACCTTTCTGTCCAGGTGATTCACAGACTAGACCTTTCTTATCCTCCTCCTAGAGTT TTGACTTGGGACTCTAGTGTTAAGATGATGAGCCCGTGCATCAGGTCCTTCTGCACTTTGGTGGAAGTCTCCCAGGGTAGGTTTCCTATT TGAAACAGTGGAATCATGTTTCCAGTGATAAAGTTTAATGACCTCATCCTTTTTTTTTTTTCTCATCTGCCATTTGTGTGTCTTAGATGG GTTTTAATTGCATGAATGTGGCTAATGTGGTTCTCAGAAATTGGTCAGTATGGCCCAACATAGCTTCTGCTCTGTCTTACTGACTCAATA CCTTTAGGATTTGTATCAGAGTTTGGATACTAGTGTTAGTGGTGGTGTCACCACTACTTAATTGGGAGATAATGAAACCAATCATGGATG CTGTTTTTATTGGGCATGTCATCTAAGAGAGGAGAAATAGCTGGGTTTTGGGTCTAATTATGAATAAGGACTGATTCAGAAAACGAGTTT ATGGTAGGTAGACTAAAGTTTCACATCAGACTGTACCATTGTGATTTAGACCTATCTAAAATTCAGAGCATATCATCTGGGCTACCTCAG GGTCACCACCCATGTATTGGGCTTAGTCAGGATTGACAGATACATTCTCAGCTGGCCTGTCATATAAAACATACTGTCATTGAGCTTAAG CTCCGCTTGTTCTGAGGTTTCACCTCCATGTGTTTCATTGGTGCAAAAGTGGATCTCTTAGTTGGTCACTTAATTCTTTCTTTTTCAGAA AGATAGTATGTTCACTGGTATATTTGGTCACTCTTAGAACCTTCCTTCACATTGTTTTTTATGGGACCCATGAATGGTTAGCCTTTCTTT TCTATTGTAGAAGGAAATAAATAGGAGTAAAAAGACCATTGTAGTAAATAAGTTCAAGGGGAACTTGGGACCAGAAACCACTGTTATGTA CAAAAAAATGGCAAATTCAATAAACTCAAATTTAAAATAATTTTTAAATTAACAGTTATGATAAATTTTATATTTTATACAAATAGATTG CTTAGAATGGTTCTCAAGAATTATAAGAGAAATGAACTCACAGTACAAAAATTTTATAATTACTATACTTGTGTTTTGTTTGGGGGCTGG GAAATGTATTTTTACATTGTAGCCAATCATTTTATATTTGTCAATTTAAATCTTATGGGTCTTTTTTTTTTATCTCTCTTGATGTCAGAT >In-frame_ENST00000402219_ENST00000205636_TCGA-61-2016_SOS1_chr2_39347476_-_CMTM6_chr3_32533378_length(amino acids)=166AA_start in transcript=41_stop in transcript=541 MQAQQLPYEFFSEENAPKWRGLLVPALKKLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDF -------------------------------------------------------------- >In-frame_ENST00000395038_ENST00000205636_TCGA-61-2016_SOS1_chr2_39347476_-_CMTM6_chr3_32533378_length(transcript)=3177nt_BP=115nt CCCCGCCCAGAGGCGCCCCGGGGGCACCATGCAGGCGCAGCAGCTGCCCTACGAGTTTTTCAGCGAAGAGAACGCGCCCAAGTGGCGGGG ACTACTGGTGCCTGCGCTGAAAAAGTTGCTGTCTCTGCTGGCCTTCATCTGTGAAGAAGTTGTATCACAATGTACTTTATGTGGAGGACT TTATTTTTTTGAGTTTGTAAGCTGCAGTGCCTTTCTTCTGAGTCTCCTTATACTGATTGTGTATTGCACTCCATTTTATGAGAGAGTTGA TACCACAAAAGTAAAATCATCGGATTTTTATATTACTTTGGGAACAGGATGTGTGTTTTTGTTGGCATCCATCATTTTTGTTTCCACACA TGACAGGACTTCAGCTGAGATTGCTGCAATTGTGTTTGGATTTATAGCAAGTTTTATGTTCCTACTTGACTTTATCACTATGCTGTATGA AAAACGACAGGAGTCCCAGCTGAGAAAACCTGAAAATACCACTAGGGCTGAAGCCCTCACTGAGCCACTTAATGCCTAAAGACTCTGGGG AGCAGATGTTACCTAAGGTAGTGACCCTGCATTGTGGTGCCTGAGCCCTGGCAGAAGCTCTTGTAAAATTTGTTAATTGTTTAAACCACT TCTTTTGGAGAGCAAGGGGAAGGTCAAGAAGGCAGTTTTATCAATATTGTGTCAGTCACCACAAAGTAGGCCAGATAAGTTAAAAAAAAT TTTTTTTTAAATAATAATTGAAACTTATCTCAAATGGAGATTTTGGTGGGAGGAGGAGAAAACAATTGTTTTTAAATCACACAGCTCAAC GGTTGATAAATGATTCTGTCATTCTGTTACAGGTCATTCTTTTACTAGGCTTAGCTTCCAAATTATGCTTTATAGCTGTATAAACATCGT GATTATATTCATCTACTTAGAAATTGTTTTATTTTTAAATTAATTTGCTTAGCTGTTTGTTTTGATGCTTAGATTATGTTCTGTTAATGG GAATTTAACATATTTAAGAAACCAATATTTAAAATGTTGGTCTAGGTTTTTTTCCTTAACATATATTACCAGGCTTTACTGTATTTCACT CAGCCTTAAATGTTATAATATTTTTGGATAACGGTTATTAATTCTTTGAGACCTTCGTATAGCCTATAAAATGTATGGGAGATGTTGGTA TTTTATGTGTATAAAAGCAACAATATCAGCAACTTCGTGTTTATACTGCACCTTGGTTGTTGATGTCAAGTAAAAAAAAGATTGTTTTGT AACACATAAAAAAATGGAAGAAACTGATACCACACCTAAGGACCAAAGATAAGAAAGACTTTTTGCCCAAGACAGTGAAAGTAATTATAA AAACAAGCTTTGACCACTTACCAAGTATCTGAAGAGATGAGTTCATACTATGATTTAGAAAGTGGTTCAATTCCCCTGTTGGCATATGAT TATTTTTACTAAAATTAATACAGCTCTGTGGGTCTTCCTTAGTGTTTTCTTTGAAGCCAATCTGTTTTTTTTAGGACACCAGCCTTTGGT TTTTCATCTGTTCGAGATGCCTCTTCTCTGTCTCCTTATCAGATAGAAATGGAGTCATGTGCTGCTGCTTCATCTAGCAGAGGTTGGCCT CTGGCTCTGACACTTTTTGTCAGTTGTCTTTAGGTGGTCCTGAATCTTGGGCCCTTTTGATTGTGAATACTGTGTAGCAGGATCTTGAGA GTCCTTGTTCTTACATAGGCATTGCTCTAGTTTGTCTTTGGCAAAAAAAAAAAAAAAAAAAAGTAAATATCCAGGGAACCCTGCCCAGAC TAATACTGTTGGTGGCATAAGAGAATCAAGCCATTCTCAAGAGATAACTTCATAACCAGAATTGTCTGTTGGCTAGCAGCTGTCACAGAT AGGCAGGGCACTTGGGATATGACCTTTCTGTCCAGGTGATTCACAGACTAGACCTTTCTTATCCTCCTCCTAGAGTTTTGACTTGGGACT CTAGTGTTAAGATGATGAGCCCGTGCATCAGGTCCTTCTGCACTTTGGTGGAAGTCTCCCAGGGTAGGTTTCCTATTTGAAACAGTGGAA TCATGTTTCCAGTGATAAAGTTTAATGACCTCATCCTTTTTTTTTTTTCTCATCTGCCATTTGTGTGTCTTAGATGGGTTTTAATTGCAT GAATGTGGCTAATGTGGTTCTCAGAAATTGGTCAGTATGGCCCAACATAGCTTCTGCTCTGTCTTACTGACTCAATACCTTTAGGATTTG TATCAGAGTTTGGATACTAGTGTTAGTGGTGGTGTCACCACTACTTAATTGGGAGATAATGAAACCAATCATGGATGCTGTTTTTATTGG GCATGTCATCTAAGAGAGGAGAAATAGCTGGGTTTTGGGTCTAATTATGAATAAGGACTGATTCAGAAAACGAGTTTATGGTAGGTAGAC TAAAGTTTCACATCAGACTGTACCATTGTGATTTAGACCTATCTAAAATTCAGAGCATATCATCTGGGCTACCTCAGGGTCACCACCCAT GTATTGGGCTTAGTCAGGATTGACAGATACATTCTCAGCTGGCCTGTCATATAAAACATACTGTCATTGAGCTTAAGCTCCGCTTGTTCT GAGGTTTCACCTCCATGTGTTTCATTGGTGCAAAAGTGGATCTCTTAGTTGGTCACTTAATTCTTTCTTTTTCAGAAAGATAGTATGTTC ACTGGTATATTTGGTCACTCTTAGAACCTTCCTTCACATTGTTTTTTATGGGACCCATGAATGGTTAGCCTTTCTTTTCTATTGTAGAAG GAAATAAATAGGAGTAAAAAGACCATTGTAGTAAATAAGTTCAAGGGGAACTTGGGACCAGAAACCACTGTTATGTACAAAAAAATGGCA AATTCAATAAACTCAAATTTAAAATAATTTTTAAATTAACAGTTATGATAAATTTTATATTTTATACAAATAGATTGCTTAGAATGGTTC TCAAGAATTATAAGAGAAATGAACTCACAGTACAAAAATTTTATAATTACTATACTTGTGTTTTGTTTGGGGGCTGGGAAATGTATTTTT ACATTGTAGCCAATCATTTTATATTTGTCAATTTAAATCTTATGGGTCTTTTTTTTTTATCTCTCTTGATGTCAGATTTTATAGTCTTTT >In-frame_ENST00000395038_ENST00000205636_TCGA-61-2016_SOS1_chr2_39347476_-_CMTM6_chr3_32533378_length(amino acids)=166AA_start in transcript=28_stop in transcript=528 MQAQQLPYEFFSEENAPKWRGLLVPALKKLLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDF -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for SOS1-CMTM6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for SOS1-CMTM6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for SOS1-CMTM6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SOS1 | C0028326 | Noonan Syndrome | 13 | CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET |
| Hgene | SOS1 | C1853120 | Noonan Syndrome 4 | 11 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | SOS1 | C1275081 | Cardio-facio-cutaneous syndrome | 7 | CLINGEN |
| Hgene | SOS1 | C0041409 | Turner Syndrome, Male | 2 | CTD_human |
| Hgene | SOS1 | C1527404 | Female Pseudo-Turner Syndrome | 2 | CTD_human |
| Hgene | SOS1 | C4551602 | Noonan Syndrome 1 | 2 | CTD_human |
| Hgene | SOS1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | SOS1 | C0399440 | Hereditary gingival fibromatosis | 1 | ORPHANET |
| Hgene | SOS1 | C0587248 | Costello syndrome (disorder) | 1 | CLINGEN |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies