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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOS2-POLN (FusionGDB2 ID:84690)

Fusion Gene Summary for SOS2-POLN

check button Fusion gene summary
Fusion gene informationFusion gene name: SOS2-POLN
Fusion gene ID: 84690
HgeneTgene
Gene symbol

SOS2

POLN

Gene ID

6655

353497

Gene nameSOS Ras/Rho guanine nucleotide exchange factor 2DNA polymerase nu
SynonymsNS9|SOS-2POL4P
Cytomap

14q21.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionson of sevenless homolog 2guanine nucleotide releasing factorDNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000216373, ENST00000543680, 
ENST00000555794, 		ENST00000382865, 
ENST00000511885, ENST00000515357, 
Fusion gene scores* DoF score12 X 11 X 6=79217 X 13 X 10=2210
# samples 1521
** MAII scorelog2(15/792*10)=-2.40053792958373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/2210*10)=-3.39558513661267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOS2 [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOS2(50697915)-POLN(2176478), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLN

GO:0019985

translesion synthesis

20102227


check buttonFusion gene breakpoints across SOS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across POLN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A5I1-01ASOS2chr14

50697915

-POLNchr4

2176478

-
ChimerDB4UCSTCGA-NA-A5I1SOS2chr14

50697915

-POLNchr4

2176478

-
ChimerDB4UCSTCGA-NA-A5I1SOS2chr14

50697915

-POLNchr4

2178061

-
ChimerDB4UCSTCGA-NA-A5I1-01ASOS2chr14

50697915

-POLNchr4

2176478

-


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Fusion Gene ORF analysis for SOS2-POLN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216373ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000216373ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
5CDS-5UTRENST00000216373ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000543680ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000543680ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
5CDS-5UTRENST00000543680ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-
intron-3CDSENST00000555794ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
intron-3CDSENST00000555794ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
intron-5UTRENST00000555794ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000216373ENST00000382865SOS2chr14

50697915

-POLNchr4

2178061

-
In-frameENST00000216373ENST00000511885SOS2chr14

50697915

-POLNchr4

2178061

-
5CDS-5UTRENST00000216373ENST00000515357SOS2chr14

50697915

-POLNchr4

2178061

-
In-frameENST00000543680ENST00000382865SOS2chr14

50697915

-POLNchr4

2178061

-
In-frameENST00000543680ENST00000511885SOS2chr14

50697915

-POLNchr4

2178061

-
5CDS-5UTRENST00000543680ENST00000515357SOS2chr14

50697915

-POLNchr4

2178061

-
intron-3CDSENST00000555794ENST00000382865SOS2chr14

50697915

-POLNchr4

2178061

-
intron-3CDSENST00000555794ENST00000511885SOS2chr14

50697915

-POLNchr4

2178061

-
intron-5UTRENST00000555794ENST00000515357SOS2chr14

50697915

-POLNchr4

2178061

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216373SOS2chr1450697915-ENST00000382865POLNchr42176478-20133622091816535
ENST00000216373SOS2chr1450697915-ENST00000511885POLNchr42176478-20133622091816535
ENST00000543680SOS2chr1450697915-ENST00000382865POLNchr42176478-1764113261567513
ENST00000543680SOS2chr1450697915-ENST00000511885POLNchr42176478-1764113261567513
ENST00000216373SOS2chr1450697915-ENST00000382865POLNchr42178061-20823622091885558
ENST00000216373SOS2chr1450697915-ENST00000511885POLNchr42178061-20823622091885558
ENST00000543680SOS2chr1450697915-ENST00000382865POLNchr42178061-1833113261636536
ENST00000543680SOS2chr1450697915-ENST00000511885POLNchr42178061-1833113261636536

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216373ENST00000382865SOS2chr1450697915-POLNchr42176478-0.0161779670.98382205
ENST00000216373ENST00000511885SOS2chr1450697915-POLNchr42176478-0.0161779670.98382205
ENST00000543680ENST00000382865SOS2chr1450697915-POLNchr42176478-0.018591180.9814089
ENST00000543680ENST00000511885SOS2chr1450697915-POLNchr42176478-0.018591180.9814089
ENST00000216373ENST00000382865SOS2chr1450697915-POLNchr42178061-0.0194611510.98053885
ENST00000216373ENST00000511885SOS2chr1450697915-POLNchr42178061-0.0194611510.98053885
ENST00000543680ENST00000382865SOS2chr1450697915-POLNchr42178061-0.0241392660.9758607
ENST00000543680ENST00000511885SOS2chr1450697915-POLNchr42178061-0.0241392660.9758607

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Fusion Genomic Features for SOS2-POLN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOS2-POLN


check button Go to

FGviewer for the breakpoints of chr14:50697915-chr4:2176478

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-1231180_118329.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-1231203_120829.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123755_75829.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-1231180_118329.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-1231203_120829.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-123755_75829.01333.0Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123198_38829.01333.0DomainDH
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123442_54629.01333.0DomainPH
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123595_73929.01333.0DomainN-terminal Ras-GEF
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123778_101729.01333.0DomainRas-GEF
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-123198_38829.01333.0DomainDH
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-123442_54629.01333.0DomainPH
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-123595_73929.01333.0DomainN-terminal Ras-GEF
HgeneSOS2chr14:50697915chr4:2178061ENST00000216373-123778_101729.01333.0DomainRas-GEF


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Fusion Gene Sequence for SOS2-POLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000216373_ENST00000382865_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(transcript)=2013nt_BP=362nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_ENST00000216373_ENST00000382865_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(amino acids)=535AA_start in transcript=209_stop in transcript=1816
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA
LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTF
VDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHL
SGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA
IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP

--------------------------------------------------------------
>In-frame_ENST00000216373_ENST00000511885_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(transcript)=2013nt_BP=362nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_ENST00000216373_ENST00000511885_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(amino acids)=535AA_start in transcript=209_stop in transcript=1816
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA
LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTF
VDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHL
SGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA
IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP

--------------------------------------------------------------
>In-frame_ENST00000543680_ENST00000382865_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(transcript)=1764nt_BP=113nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGG
AAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTC
ATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTC
AAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTAC
CCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTT
CCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGA
TTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCT
TTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTG
AAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGA
AGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGG
AGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCA
TGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGC
AAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGG
CCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGG
AACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGC
AGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGC
CCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGG
CCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTG

>In-frame_ENST00000543680_ENST00000382865_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(amino acids)=513AA_start in transcript=26_stop in transcript=1567
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

--------------------------------------------------------------
>In-frame_ENST00000543680_ENST00000511885_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(transcript)=1764nt_BP=113nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGG
AAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTC
ATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTC
AAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTAC
CCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTT
CCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGA
TTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCT
TTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTG
AAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGA
AGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGG
AGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCA
TGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGC
AAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGG
CCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGG
AACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGC
AGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGC
CCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGG
CCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTG

>In-frame_ENST00000543680_ENST00000511885_TCGA-NA-A5I1-01A_SOS2_chr14_50697915_-_POLN_chr4_2176478_length(amino acids)=513AA_start in transcript=26_stop in transcript=1567
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

--------------------------------------------------------------
>In-frame_ENST00000216373_ENST00000382865_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(transcript)=2082nt_BP=362nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAAC
TATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGA
CGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACC
AGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGT
CTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGT
CAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTT
CAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTC
TCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTA
CACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGG
ATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGC
TGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCC
GAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACC
AGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATG
TCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGC
AGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCA
AGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGT
CTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCC
AGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATT
AACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTTCCTGT

>In-frame_ENST00000216373_ENST00000382865_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(amino acids)=558AA_start in transcript=209_stop in transcript=1885
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLI
PILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNAL
RDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFV
SSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQ
EAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHT
LTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPG

--------------------------------------------------------------
>In-frame_ENST00000216373_ENST00000511885_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(transcript)=2082nt_BP=362nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGAAGGATTATGGTTTATGGCAAC
TATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGA
CGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACC
AGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGT
CTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGT
CAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTT
CAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTC
TCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTA
CACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGG
ATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGC
TGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCC
GAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACC
AGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATG
TCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGC
AGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCA
AGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGT
CTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCC
AGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATT
AACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTTGTCTGAGTGAATTCTTCCTGT

>In-frame_ENST00000216373_ENST00000511885_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(amino acids)=558AA_start in transcript=209_stop in transcript=1885
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLI
PILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNAL
RDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFV
SSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQ
EAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHT
LTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPG

--------------------------------------------------------------
>In-frame_ENST00000543680_ENST00000382865_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(transcript)=1833nt_BP=113nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_ENST00000543680_ENST00000382865_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(amino acids)=536AA_start in transcript=26_stop in transcript=1636
MQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKST
FVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTH
LSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARA
AIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQI

--------------------------------------------------------------
>In-frame_ENST00000543680_ENST00000511885_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(transcript)=1833nt_BP=113nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGAATCAGAATGTACGTGAGAACCTGAAGACACTCTACAGACTTACAATGGACCTTTGCTCTAAACTGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_ENST00000543680_ENST00000511885_TCGA-NA-A5I1_SOS2_chr14_50697915_-_POLN_chr4_2178061_length(amino acids)=536AA_start in transcript=26_stop in transcript=1636
MQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKST
FVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTH
LSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARA
AIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SOS2-POLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOS2-POLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOS2-POLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOS2C0028326Noonan Syndrome4CLINGEN;GENOMICS_ENGLAND;ORPHANET
HgeneSOS2C4225282NOONAN SYNDROME 92CTD_human;GENOMICS_ENGLAND;UNIPROT