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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SOX6-GALNT18 (FusionGDB2 ID:84761)

Fusion Gene Summary for SOX6-GALNT18

check button Fusion gene summary
Fusion gene informationFusion gene name: SOX6-GALNT18
Fusion gene ID: 84761
HgeneTgene
Gene symbol

SOX6

GALNT18

Gene ID

55553

374378

Gene nameSRY-box transcription factor 6polypeptide N-acetylgalactosaminyltransferase 18
SynonymsHSSOX6|SOXDGALNACT18|GALNT15|GALNTL4|GalNAc-T15|GalNAc-T18
Cytomap

11p15.2

11p15.4

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor SOX-6SRY (sex determining region Y)-box 6SRY-box 6SRY-box containing gene 6polypeptide N-acetylgalactosaminyltransferase 18GalNAc-transferase 18UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-N-acetyl-alpha-D-galacto
Modification date2020031320200313
UniProtAcc.

Q6P9A2

Ensembl transtripts involved in fusion geneENST00000316399, ENST00000396356, 
ENST00000352083, ENST00000528252, 
ENST00000527619, ENST00000528429, 
ENST00000533658, 		ENST00000227756, 
ENST00000526064, 
Fusion gene scores* DoF score13 X 12 X 8=12488 X 7 X 5=280
# samples 148
** MAII scorelog2(14/1248*10)=-3.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOX6 [Title/Abstract] AND GALNT18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSOX6(16339992)-GALNT18(11400811), # samples:2
Anticipated loss of major functional domain due to fusion event.SOX6-GALNT18 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SOX6-GALNT18 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSOX6

GO:0032332

positive regulation of chondrocyte differentiation

21401405

HgeneSOX6

GO:0061036

positive regulation of cartilage development

21401405

HgeneSOX6

GO:0071560

cellular response to transforming growth factor beta stimulus

21401405

HgeneSOX6

GO:2000741

positive regulation of mesenchymal stem cell differentiation

21401405

TgeneGALNT18

GO:0006493

protein O-linked glycosylation

22186971


check buttonFusion gene breakpoints across SOX6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GALNT18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A24Q-01ASOX6chr11

16339992

-GALNT18chr11

11400811

-
ChimerDB4BRCATCGA-AR-A24Q-01ASOX6chr11

16339992

-GALNT18chr11

11400811

-


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Fusion Gene ORF analysis for SOX6-GALNT18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000316399ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000316399ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
In-frameENST00000396356ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000396356ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
In-frameENST00000352083ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000352083ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
Frame-shiftENST00000528252ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000528252ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
In-frameENST00000527619ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000527619ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
Frame-shiftENST00000528429ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
5CDS-intronENST00000528429ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-
intron-3CDSENST00000533658ENST00000227756SOX6chr11

16339992

-GALNT18chr11

11400811

-
intron-intronENST00000533658ENST00000526064SOX6chr11

16339992

-GALNT18chr11

11400811

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316399SOX6chr1116339992-ENST00000227756GALNT18chr1111400811-196346601694564
ENST00000396356SOX6chr1116339992-ENST00000227756GALNT18chr1111400811-2020523391751570
ENST00000352083SOX6chr1116339992-ENST00000227756GALNT18chr1111400811-2020523391751570
ENST00000527619SOX6chr1116339992-ENST00000227756GALNT18chr1111400811-21346371831865560

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316399ENST00000227756SOX6chr1116339992-GALNT18chr1111400811-0.0037222990.99627763
ENST00000396356ENST00000227756SOX6chr1116339992-GALNT18chr1111400811-0.0032677350.99673223
ENST00000352083ENST00000227756SOX6chr1116339992-GALNT18chr1111400811-0.0032677350.99673223
ENST00000527619ENST00000227756SOX6chr1116339992-GALNT18chr1111400811-0.0031910680.99680895

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Fusion Genomic Features for SOX6-GALNT18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SOX6-GALNT18


check button Go to

FGviewer for the breakpoints of chr11:16339992-chr11:11400811

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GALNT18

Q6P9A2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000269|PubMed:22186971}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGALNT18chr11:16339992chr11:11400811ENST00000227756211469_599198.33333333333334608.0DomainRicin B-type lectin
TgeneGALNT18chr11:16339992chr11:11400811ENST00000227756211324_385198.33333333333334608.0RegionNote=Catalytic subdomain B

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOX6chr11:16339992chr11:11400811ENST00000316399-215184_262148.33333333333334809.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000352083-316184_262148.33333333333334829.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000396356-316184_262148.33333333333334809.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000527619-315184_262151.33333333333334805.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000528252-315184_262148.33333333333334802.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000528429-316184_262148.33333333333334829.0Coiled coilOntology_term=ECO:0000255
HgeneSOX6chr11:16339992chr11:11400811ENST00000316399-215219_261148.33333333333334809.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000316399-215280_285148.33333333333334809.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000316399-215313_317148.33333333333334809.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000352083-316219_261148.33333333333334829.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000352083-316280_285148.33333333333334829.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000352083-316313_317148.33333333333334829.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000396356-316219_261148.33333333333334809.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000396356-316280_285148.33333333333334809.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000396356-316313_317148.33333333333334809.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000527619-315219_261151.33333333333334805.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000527619-315280_285151.33333333333334805.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000527619-315313_317151.33333333333334805.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000528252-315219_261148.33333333333334802.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000528252-315280_285148.33333333333334802.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000528252-315313_317148.33333333333334802.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000528429-316219_261148.33333333333334829.0Compositional biasNote=Gln-rich
HgeneSOX6chr11:16339992chr11:11400811ENST00000528429-316280_285148.33333333333334829.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000528429-316313_317148.33333333333334829.0Compositional biasNote=Poly-Ala
HgeneSOX6chr11:16339992chr11:11400811ENST00000316399-215621_689148.33333333333334809.0DNA bindingHMG box
HgeneSOX6chr11:16339992chr11:11400811ENST00000352083-316621_689148.33333333333334829.0DNA bindingHMG box
HgeneSOX6chr11:16339992chr11:11400811ENST00000396356-316621_689148.33333333333334809.0DNA bindingHMG box
HgeneSOX6chr11:16339992chr11:11400811ENST00000527619-315621_689151.33333333333334805.0DNA bindingHMG box
HgeneSOX6chr11:16339992chr11:11400811ENST00000528252-315621_689148.33333333333334802.0DNA bindingHMG box
HgeneSOX6chr11:16339992chr11:11400811ENST00000528429-316621_689148.33333333333334829.0DNA bindingHMG box
TgeneGALNT18chr11:16339992chr11:11400811ENST00000227756211153_267198.33333333333334608.0RegionNote=Catalytic subdomain A
TgeneGALNT18chr11:16339992chr11:11400811ENST000002277562111_12198.33333333333334608.0Topological domainCytoplasmic
TgeneGALNT18chr11:16339992chr11:11400811ENST0000022775621136_607198.33333333333334608.0Topological domainLumenal
TgeneGALNT18chr11:16339992chr11:11400811ENST0000022775621113_35198.33333333333334608.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for SOX6-GALNT18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000316399_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(transcript)=1963nt_BP=466nt
CTGTTTTTTTTCTGCAGAAGAATGTCTTCCAAGCAAGCCACCTCTCCATTTGCCTGTGCAGCTGATGGAGAGGATGCAATGACCCAGGAT
TTAACCTCAAGGGAAAAGGAAGAGGGCAGTGATCAACATGTGGCCTCCCATCTGCCTCTGCACCCCATAATGCACAACAAACCTCACTCT
GAGGAGCTACCAACACTTGTCAGTACCATTCAACAAGATGCTGACTGGGACAGCGTTCTGTCATCTCAGCAAAGAATGGAATCAGAGAAT
AATAAGTTATGTTCCCTATATTCCTTCCGAAATACCTCTACCTCACCACATAAGCCTGACGAAGGGAGTCGGGACCGTGAGATAATGACC
AGTGTTACTTTTGGAACCCCAGAGCGCCGCAAAGGGAGTCTTGCCGATGTGGTGGACACACTGAAACAGAAGAAGCTTGAGGAAATGACT
CGGACTGAACAAGAGGAGGAACTGAAGGAGAAGCTGACCGAATATGTGGACAAGGTGAACAGCCAGAAGCCAGGCTTCATCAAAGTCGTG
CGTCACAGCAAGCAGGAAGGCCTCATCCGCTCCAGGGTCAGTGGCTGGAGGGCGGCCACTGCCCCTGTGGTGGCACTCTTTGATGCCCAC
GTGGAGTTCAATGTGGGCTGGGCTGAACCTGTACTCACCCGCATCAAGGAGAACCGGAAGCGGATCATCTCGCCATCCTTTGATAACATC
AAATATGACAACTTTGAGATAGAAGAGTACCCGCTGGCTGCCCAGGGCTTTGACTGGGAGCTGTGGTGCCGCTACCTAAATCCCCCCAAG
GCCTGGTGGAAGCTGGAGAACTCCACAGCGCCAATCAGGAGCCCTGCCCTCATTGGCTGCTTCATTGTGGACCGGCAGTACTTCCAGGAG
ATCGGCCTGCTGGACGAAGGCATGGAAGTCTACGGGGGCGAGAATGTGGAGCTTGGGATCAGGGTGTGGCAGTGTGGCGGGAGTGTGGAG
GTCCTGCCCTGCTCACGGATTGCCCACATTGAGCGAGCCCACAAGCCCTACACAGAGGACCTCACCGCCCATGTCCGCAGGAACGCTCTC
AGGGTGGCTGAAGTCTGGATGGATGAATTTAAAAGCCACGTCTACATGGCATGGAACATACCGCAGGAGGACTCAGGAATTGACATTGGG
GACATCACTGCAAGGAAGGCTCTCAGGAAACAGCTGCAGTGCAAGACCTTCCGGTGGTACCTGGTCAGCGTGTACCCAGAGATGAGGATG
TACTCCGACATCATTGCCTATGGAGTGCTGCAGAATTCTCTGAAGACTGATTTGTGTCTTGACCAGGGGCCAGATACAGAGAATGTCCCC
ATCATGTACATCTGCCATGGGATGACGCCTCAGAACGTGTACTACACGAGCAGTCAGCAGATCCATGTGGGCATTCTGAGCCCCACCGTG
GATGATGATGACAACCGATGCCTGGTGGACGTCAACAGCCGGCCCCGGCTCATCGAATGCAGCTACGCCAAAGCCAAGAGGATGAAGCTT
CACTGGCAGTTCTCTCAGGGAGGACCCATCCAGAACCGCAAGTCTAAGCGCTGTCTGGAGCTGCAGGAGAATAGCGACCTGGAGTTCGGC
TTCCAGCTGGTGTTGCAGAAGTGCTCGGGCCAGCACTGGAGCATCACCAACGTCCTGAGGAGCCTCGCGTCCTGACCCACCGGGGCCACT
TCCGGCTGCCTCTTTGCTACTGTGTAGCACCTGCTGCAACGTTGCCTGCTGTCCACGTGGGGTTGTTTGGAGTCTGGGGAACCAGGTTAG
TGGGCCCCCAAGAAGAGCTTTTTATTTCCTATTCAATTTTCATGGAGTTTATAGAAAGATGCTGATTGGTAGGTGATGGTATGATATCAA

>In-frame_ENST00000316399_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(amino acids)=564AA_start in transcript=0_stop in transcript=1694
LFFFCRRMSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESEN
NKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEEELKEKLTEYVDKVNSQKPGFIKVV
RHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPK
AWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAHVRRNAL
RVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTENVP
IMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFG

--------------------------------------------------------------
>In-frame_ENST00000396356_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(transcript)=2020nt_BP=523nt
GTCACTTTCATGAATTCAAAGGCAATTTACCAGTGATTTCTGGGTGCTGGGGCTGATATTTTTTGTGCATATTTAAGAATGTCTTCCAAG
CAAGCCACCTCTCCATTTGCCTGTGCAGCTGATGGAGAGGATGCAATGACCCAGGATTTAACCTCAAGGGAAAAGGAAGAGGGCAGTGAT
CAACATGTGGCCTCCCATCTGCCTCTGCACCCCATAATGCACAACAAACCTCACTCTGAGGAGCTACCAACACTTGTCAGTACCATTCAA
CAAGATGCTGACTGGGACAGCGTTCTGTCATCTCAGCAAAGAATGGAATCAGAGAATAATAAGTTATGTTCCCTATATTCCTTCCGAAAT
ACCTCTACCTCACCACATAAGCCTGACGAAGGGAGTCGGGACCGTGAGATAATGACCAGTGTTACTTTTGGAACCCCAGAGCGCCGCAAA
GGGAGTCTTGCCGATGTGGTGGACACACTGAAACAGAAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGAGGAACTGAAGGAGAAG
CTGACCGAATATGTGGACAAGGTGAACAGCCAGAAGCCAGGCTTCATCAAAGTCGTGCGTCACAGCAAGCAGGAAGGCCTCATCCGCTCC
AGGGTCAGTGGCTGGAGGGCGGCCACTGCCCCTGTGGTGGCACTCTTTGATGCCCACGTGGAGTTCAATGTGGGCTGGGCTGAACCTGTA
CTCACCCGCATCAAGGAGAACCGGAAGCGGATCATCTCGCCATCCTTTGATAACATCAAATATGACAACTTTGAGATAGAAGAGTACCCG
CTGGCTGCCCAGGGCTTTGACTGGGAGCTGTGGTGCCGCTACCTAAATCCCCCCAAGGCCTGGTGGAAGCTGGAGAACTCCACAGCGCCA
ATCAGGAGCCCTGCCCTCATTGGCTGCTTCATTGTGGACCGGCAGTACTTCCAGGAGATCGGCCTGCTGGACGAAGGCATGGAAGTCTAC
GGGGGCGAGAATGTGGAGCTTGGGATCAGGGTGTGGCAGTGTGGCGGGAGTGTGGAGGTCCTGCCCTGCTCACGGATTGCCCACATTGAG
CGAGCCCACAAGCCCTACACAGAGGACCTCACCGCCCATGTCCGCAGGAACGCTCTCAGGGTGGCTGAAGTCTGGATGGATGAATTTAAA
AGCCACGTCTACATGGCATGGAACATACCGCAGGAGGACTCAGGAATTGACATTGGGGACATCACTGCAAGGAAGGCTCTCAGGAAACAG
CTGCAGTGCAAGACCTTCCGGTGGTACCTGGTCAGCGTGTACCCAGAGATGAGGATGTACTCCGACATCATTGCCTATGGAGTGCTGCAG
AATTCTCTGAAGACTGATTTGTGTCTTGACCAGGGGCCAGATACAGAGAATGTCCCCATCATGTACATCTGCCATGGGATGACGCCTCAG
AACGTGTACTACACGAGCAGTCAGCAGATCCATGTGGGCATTCTGAGCCCCACCGTGGATGATGATGACAACCGATGCCTGGTGGACGTC
AACAGCCGGCCCCGGCTCATCGAATGCAGCTACGCCAAAGCCAAGAGGATGAAGCTTCACTGGCAGTTCTCTCAGGGAGGACCCATCCAG
AACCGCAAGTCTAAGCGCTGTCTGGAGCTGCAGGAGAATAGCGACCTGGAGTTCGGCTTCCAGCTGGTGTTGCAGAAGTGCTCGGGCCAG
CACTGGAGCATCACCAACGTCCTGAGGAGCCTCGCGTCCTGACCCACCGGGGCCACTTCCGGCTGCCTCTTTGCTACTGTGTAGCACCTG
CTGCAACGTTGCCTGCTGTCCACGTGGGGTTGTTTGGAGTCTGGGGAACCAGGTTAGTGGGCCCCCAAGAAGAGCTTTTTATTTCCTATT
CAATTTTCATGGAGTTTATAGAAAGATGCTGATTGGTAGGTGATGGTATGATATCAAACTATTTTGCAGTTGTAAATAGGGGACAGATGG

>In-frame_ENST00000396356_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(amino acids)=570AA_start in transcript=39_stop in transcript=1751
MGAGADIFCAYLRMSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQ
RMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEEELKEKLTEYVDKVNSQKP
GFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCR
YLNPPKAWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAH
VRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGP
DTENVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQEN

--------------------------------------------------------------
>In-frame_ENST00000352083_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(transcript)=2020nt_BP=523nt
GTCACTTTCATGAATTCAAAGGCAATTTACCAGTGATTTCTGGGTGCTGGGGCTGATATTTTTTGTGCATATTTAAGAATGTCTTCCAAG
CAAGCCACCTCTCCATTTGCCTGTGCAGCTGATGGAGAGGATGCAATGACCCAGGATTTAACCTCAAGGGAAAAGGAAGAGGGCAGTGAT
CAACATGTGGCCTCCCATCTGCCTCTGCACCCCATAATGCACAACAAACCTCACTCTGAGGAGCTACCAACACTTGTCAGTACCATTCAA
CAAGATGCTGACTGGGACAGCGTTCTGTCATCTCAGCAAAGAATGGAATCAGAGAATAATAAGTTATGTTCCCTATATTCCTTCCGAAAT
ACCTCTACCTCACCACATAAGCCTGACGAAGGGAGTCGGGACCGTGAGATAATGACCAGTGTTACTTTTGGAACCCCAGAGCGCCGCAAA
GGGAGTCTTGCCGATGTGGTGGACACACTGAAACAGAAGAAGCTTGAGGAAATGACTCGGACTGAACAAGAGGAGGAACTGAAGGAGAAG
CTGACCGAATATGTGGACAAGGTGAACAGCCAGAAGCCAGGCTTCATCAAAGTCGTGCGTCACAGCAAGCAGGAAGGCCTCATCCGCTCC
AGGGTCAGTGGCTGGAGGGCGGCCACTGCCCCTGTGGTGGCACTCTTTGATGCCCACGTGGAGTTCAATGTGGGCTGGGCTGAACCTGTA
CTCACCCGCATCAAGGAGAACCGGAAGCGGATCATCTCGCCATCCTTTGATAACATCAAATATGACAACTTTGAGATAGAAGAGTACCCG
CTGGCTGCCCAGGGCTTTGACTGGGAGCTGTGGTGCCGCTACCTAAATCCCCCCAAGGCCTGGTGGAAGCTGGAGAACTCCACAGCGCCA
ATCAGGAGCCCTGCCCTCATTGGCTGCTTCATTGTGGACCGGCAGTACTTCCAGGAGATCGGCCTGCTGGACGAAGGCATGGAAGTCTAC
GGGGGCGAGAATGTGGAGCTTGGGATCAGGGTGTGGCAGTGTGGCGGGAGTGTGGAGGTCCTGCCCTGCTCACGGATTGCCCACATTGAG
CGAGCCCACAAGCCCTACACAGAGGACCTCACCGCCCATGTCCGCAGGAACGCTCTCAGGGTGGCTGAAGTCTGGATGGATGAATTTAAA
AGCCACGTCTACATGGCATGGAACATACCGCAGGAGGACTCAGGAATTGACATTGGGGACATCACTGCAAGGAAGGCTCTCAGGAAACAG
CTGCAGTGCAAGACCTTCCGGTGGTACCTGGTCAGCGTGTACCCAGAGATGAGGATGTACTCCGACATCATTGCCTATGGAGTGCTGCAG
AATTCTCTGAAGACTGATTTGTGTCTTGACCAGGGGCCAGATACAGAGAATGTCCCCATCATGTACATCTGCCATGGGATGACGCCTCAG
AACGTGTACTACACGAGCAGTCAGCAGATCCATGTGGGCATTCTGAGCCCCACCGTGGATGATGATGACAACCGATGCCTGGTGGACGTC
AACAGCCGGCCCCGGCTCATCGAATGCAGCTACGCCAAAGCCAAGAGGATGAAGCTTCACTGGCAGTTCTCTCAGGGAGGACCCATCCAG
AACCGCAAGTCTAAGCGCTGTCTGGAGCTGCAGGAGAATAGCGACCTGGAGTTCGGCTTCCAGCTGGTGTTGCAGAAGTGCTCGGGCCAG
CACTGGAGCATCACCAACGTCCTGAGGAGCCTCGCGTCCTGACCCACCGGGGCCACTTCCGGCTGCCTCTTTGCTACTGTGTAGCACCTG
CTGCAACGTTGCCTGCTGTCCACGTGGGGTTGTTTGGAGTCTGGGGAACCAGGTTAGTGGGCCCCCAAGAAGAGCTTTTTATTTCCTATT
CAATTTTCATGGAGTTTATAGAAAGATGCTGATTGGTAGGTGATGGTATGATATCAAACTATTTTGCAGTTGTAAATAGGGGACAGATGG

>In-frame_ENST00000352083_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(amino acids)=570AA_start in transcript=39_stop in transcript=1751
MGAGADIFCAYLRMSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQ
RMESENNKLCSLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEEELKEKLTEYVDKVNSQKP
GFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCR
YLNPPKAWWKLENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAH
VRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGP
DTENVPIMYICHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQEN

--------------------------------------------------------------
>In-frame_ENST00000527619_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(transcript)=2134nt_BP=637nt
GGGATAGGAAAGATGAAAGGTCATGGTGAGCTTCAAGGACATGAAAGGTTGTTGTCTCATGTAACAATAGTAGATTGTTTTTTTTCCTAA
TATTTCTAGCCAGCCCCTAAGTCAGGTGATGGAACAAATACCTACAGTTTAGTCAGGTGAAACAGGAGTGGGTGGAGGAAGGAAAGAAGA
AAAATGGGAAGAATGTCTTCCAAGCAAGCCACCTCTCCATTTGCCTGTGCAGCTGATGGAGAGGATGCAATGACCCAGGATTTAACCTCA
AGGGAAAAGGAAGAGGGCAGTGATCAACATGTGGCCTCCCATCTGCCTCTGCACCCCATAATGCACAACAAACCTCACTCTGAGGAGCTA
CCAACACTTGTCAGTACCATTCAACAAGATGCTGACTGGGACAGCGTTCTGTCATCTCAGCAAAGAATGGAATCAGAGAATAATAAGTTA
TGTTCCCTATATTCCTTCCGAAATACCTCTACCTCACCACATAAGCCTGACGAAGGGAGTCGGGACCGTGAGATAATGACCAGTGTTACT
TTTGGAACCCCAGAGCGCCGCAAAGGGAGTCTTGCCGATGTGGTGGACACACTGAAACAGAAGAAGCTTGAGGAAATGACTCGGACTGAA
CAAGAGGAGGAACTGAAGGAGAAGCTGACCGAATATGTGGACAAGGTGAACAGCCAGAAGCCAGGCTTCATCAAAGTCGTGCGTCACAGC
AAGCAGGAAGGCCTCATCCGCTCCAGGGTCAGTGGCTGGAGGGCGGCCACTGCCCCTGTGGTGGCACTCTTTGATGCCCACGTGGAGTTC
AATGTGGGCTGGGCTGAACCTGTACTCACCCGCATCAAGGAGAACCGGAAGCGGATCATCTCGCCATCCTTTGATAACATCAAATATGAC
AACTTTGAGATAGAAGAGTACCCGCTGGCTGCCCAGGGCTTTGACTGGGAGCTGTGGTGCCGCTACCTAAATCCCCCCAAGGCCTGGTGG
AAGCTGGAGAACTCCACAGCGCCAATCAGGAGCCCTGCCCTCATTGGCTGCTTCATTGTGGACCGGCAGTACTTCCAGGAGATCGGCCTG
CTGGACGAAGGCATGGAAGTCTACGGGGGCGAGAATGTGGAGCTTGGGATCAGGGTGTGGCAGTGTGGCGGGAGTGTGGAGGTCCTGCCC
TGCTCACGGATTGCCCACATTGAGCGAGCCCACAAGCCCTACACAGAGGACCTCACCGCCCATGTCCGCAGGAACGCTCTCAGGGTGGCT
GAAGTCTGGATGGATGAATTTAAAAGCCACGTCTACATGGCATGGAACATACCGCAGGAGGACTCAGGAATTGACATTGGGGACATCACT
GCAAGGAAGGCTCTCAGGAAACAGCTGCAGTGCAAGACCTTCCGGTGGTACCTGGTCAGCGTGTACCCAGAGATGAGGATGTACTCCGAC
ATCATTGCCTATGGAGTGCTGCAGAATTCTCTGAAGACTGATTTGTGTCTTGACCAGGGGCCAGATACAGAGAATGTCCCCATCATGTAC
ATCTGCCATGGGATGACGCCTCAGAACGTGTACTACACGAGCAGTCAGCAGATCCATGTGGGCATTCTGAGCCCCACCGTGGATGATGAT
GACAACCGATGCCTGGTGGACGTCAACAGCCGGCCCCGGCTCATCGAATGCAGCTACGCCAAAGCCAAGAGGATGAAGCTTCACTGGCAG
TTCTCTCAGGGAGGACCCATCCAGAACCGCAAGTCTAAGCGCTGTCTGGAGCTGCAGGAGAATAGCGACCTGGAGTTCGGCTTCCAGCTG
GTGTTGCAGAAGTGCTCGGGCCAGCACTGGAGCATCACCAACGTCCTGAGGAGCCTCGCGTCCTGACCCACCGGGGCCACTTCCGGCTGC
CTCTTTGCTACTGTGTAGCACCTGCTGCAACGTTGCCTGCTGTCCACGTGGGGTTGTTTGGAGTCTGGGGAACCAGGTTAGTGGGCCCCC
AAGAAGAGCTTTTTATTTCCTATTCAATTTTCATGGAGTTTATAGAAAGATGCTGATTGGTAGGTGATGGTATGATATCAAACTATTTTG

>In-frame_ENST00000527619_ENST00000227756_TCGA-AR-A24Q-01A_SOX6_chr11_16339992_-_GALNT18_chr11_11400811_length(amino acids)=560AA_start in transcript=183_stop in transcript=1865
MGRMSSKQATSPFACAADGEDAMTQDLTSREKEEGSDQHVASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLC
SLYSFRNTSTSPHKPDEGSRDREIMTSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEEELKEKLTEYVDKVNSQKPGFIKVVRHSK
QEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEEYPLAAQGFDWELWCRYLNPPKAWWK
LENSTAPIRSPALIGCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYTEDLTAHVRRNALRVAE
VWMDEFKSHVYMAWNIPQEDSGIDIGDITARKALRKQLQCKTFRWYLVSVYPEMRMYSDIIAYGVLQNSLKTDLCLDQGPDTENVPIMYI
CHGMTPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRPRLIECSYAKAKRMKLHWQFSQGGPIQNRKSKRCLELQENSDLEFGFQLV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SOX6-GALNT18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SOX6-GALNT18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SOX6-GALNT18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOX6C3495676Anorectal Malformations1GENOMICS_ENGLAND