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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SP3-OLA1 (FusionGDB2 ID:84813)

Fusion Gene Summary for SP3-OLA1

Fusion gene summary

Fusion gene information	Fusion gene name: SP3-OLA1
	Fusion gene ID: 84813
		Hgene	Tgene
	Gene symbol	SP3	OLA1
	Gene ID	6670	29789
	Gene name	Sp3 transcription factor	Obg like ATPase 1
	Synonyms	SPR2	DOC45\|GBP45\|GTBP9\|GTPBP9\|PTD004
	Cytomap	2q31.1	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor Sp3GC-binding transcription factor Sp3specificity protein 3	obg-like ATPase 1DNA damage-regulated overexpressed in cancer 45 proteinGTP-binding protein 9 (putative)GTP-binding protein PTD004homologous yeast-44.2 protein
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000455789, ENST00000310015, ENST00000418194, ENST00000483084,	ENST00000284719, ENST00000344357, ENST00000428402, ENST00000409546, ENST00000392560,
Fusion gene scores	* DoF score	12 X 8 X 9=864	14 X 8 X 7=784
	# samples	18	14
	** MAII score	log2(18/864*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/784*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SP3 [Title/Abstract] AND OLA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SP3(174819601)-OLA1(175006728), # samples:4 OLA1(175087761)-SP3(174820960), # samples:1
Anticipated loss of major functional domain due to fusion event.	SP3-OLA1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. OLA1-SP3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SP3	GO:0006355	regulation of transcription, DNA-templated	12560508
Hgene	SP3	GO:0045893	positive regulation of transcription, DNA-templated	12771217
Tgene	OLA1	GO:0046034	ATP metabolic process	17430889

Fusion gene breakpoints across SP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across OLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A12F-01A	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
ChimerDB4	CESC	TCGA-DS-A3LQ-01A	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
ChimerDB4	BRCA	TCGA-AO-A12F-01A	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
ChimerDB4	CESC	TCGA-DS-A3LQ-01A	SP3	chr2	174819601	-	OLA1	chr2	175006728	-

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Fusion Gene ORF analysis for SP3-OLA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000455789	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000455789	ENST00000344357	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000455789	ENST00000428402	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000455789	ENST00000409546	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-intron	ENST00000455789	ENST00000392560	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
In-frame	ENST00000310015	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000310015	ENST00000344357	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000310015	ENST00000428402	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000310015	ENST00000409546	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-intron	ENST00000310015	ENST00000392560	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
In-frame	ENST00000418194	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000418194	ENST00000344357	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000418194	ENST00000428402	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-5UTR	ENST00000418194	ENST00000409546	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
5CDS-intron	ENST00000418194	ENST00000392560	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
intron-3CDS	ENST00000483084	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
intron-5UTR	ENST00000483084	ENST00000344357	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
intron-5UTR	ENST00000483084	ENST00000428402	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
intron-5UTR	ENST00000483084	ENST00000409546	SP3	chr2	174819601	-	OLA1	chr2	175006728	-
intron-intron	ENST00000483084	ENST00000392560	SP3	chr2	174819601	-	OLA1	chr2	175006728	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000310015	SP3	chr2	174819601	-	ENST00000284719	OLA1	chr2	175006728	-	5967	2170	510	2987	825
ENST00000418194	SP3	chr2	174819601	-	ENST00000284719	OLA1	chr2	175006728	-	5616	1819	360	2636	758

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310015	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-	0.000217632	0.9997824
ENST00000418194	ENST00000284719	SP3	chr2	174819601	-	OLA1	chr2	175006728	-	0.00030224	0.9996978

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Fusion Genomic Features for SP3-OLA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SP3-OLA1

Go to
FGviewer for the breakpoints of chr2:174819601-chr2:175006728
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

21_31

546.3333333333334

782.0

Compositional bias

Note=Poly-Gly

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

35_39

546.3333333333334

782.0

Compositional bias

Note=Poly-Gln

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

44_100

546.3333333333334

782.0

Compositional bias

Note=Ala-rich

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

21_31

493.3333333333333

729.0

Compositional bias

Note=Poly-Gly

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

35_39

493.3333333333333

729.0

Compositional bias

Note=Poly-Gln

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

44_100

493.3333333333333

729.0

Compositional bias

Note=Ala-rich

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

461_469

546.3333333333334

782.0

Motif

9aaTAD

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

461_469

493.3333333333333

729.0

Motif

9aaTAD

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

138_237

546.3333333333334

782.0

Region

Note=Transactivation domain (Gln-rich)

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

350_499

546.3333333333334

782.0

Region

Note=Transactivation domain (Gln-rich)

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

138_237

493.3333333333333

729.0

Region

Note=Transactivation domain (Gln-rich)

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000284719

304_387

124.33333333333333

397.0

Domain

TGS

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000344357

23_283

239.0

Domain

OBG-type G

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000344357

304_387

239.0

Domain

TGS

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000428402

304_387

124.33333333333333

279.0

Domain

TGS

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000284719

267_274

124.33333333333333

397.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000344357

267_274

239.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000428402

267_274

124.33333333333333

279.0

Motif

Nuclear export signal

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000344357

32_37

239.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

534_620

546.3333333333334

782.0

Region

Note=Repressor domain

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

350_499

493.3333333333333

729.0

Region

Note=Transactivation domain (Gln-rich)

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

534_620

493.3333333333333

729.0

Region

Note=Repressor domain

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

621_645

546.3333333333334

782.0

Zinc finger

C2H2-type 1

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

651_675

546.3333333333334

782.0

Zinc finger

C2H2-type 2

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000310015

681_703

546.3333333333334

782.0

Zinc finger

C2H2-type 3

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

621_645

493.3333333333333

729.0

Zinc finger

C2H2-type 1

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

651_675

493.3333333333333

729.0

Zinc finger

C2H2-type 2

Hgene

SP3

chr2:174819601

chr2:175006728

ENST00000455789

681_703

493.3333333333333

729.0

Zinc finger

C2H2-type 3

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000284719

23_283

124.33333333333333

397.0

Domain

OBG-type G

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000428402

23_283

124.33333333333333

279.0

Domain

OBG-type G

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000284719

32_37

124.33333333333333

397.0

Nucleotide binding

ATP

Tgene

OLA1

chr2:174819601

chr2:175006728

ENST00000428402

32_37

124.33333333333333

279.0

Nucleotide binding

ATP

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Fusion Gene Sequence for SP3-OLA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000310015_ENST00000284719_TCGA-AO-A12F-01A_SP3_chr2_174819601_-_OLA1_chr2_175006728_length(transcript)=5967nt_BP=2170nt
GGGACGAATTTCCTCCCCAGCTCAGCTCCCCTACAGCTTGGCTAGGCCTGCTCCGAGCGCCTGCAAGGTGGAGGAGGCCTGCGCCTCGGG
CCTGGCAGCGGCAGCCGGCGAGGGAGGCGGGCACAGCGGGGTAACCGGCGAGCCGTAGCCGCTCTCGAAAACCTACGCTGCCACGGCCGC
TCATTGTCTCTCCCCTTCCACCCGGGGGCAAACAGGAAGCGCGCCGCCTGGCAGACCGACGGACAGGCGCCTGGACCAATGAGCACAGCC
GACAAAGAGCACGGCGGCGAATGAGAGCCAAGAAGAGGGGCGGGAGTTCCGGGCGGGCTGTCACCCTCTTCCCCCCTTTTGGGCTGGAGG
CTCCACCTTTTGTGTTTCCCGCACAGTCAATCAAAATAGGAAAAAAAAATCCCCGGACCGCTCCGGCCGTGTCCGCCGCCGCTTCCCGCA
TCCTCTCCCGCCGCCGCCGCCTTCGCTCCTCACCATGTGTAAGGCGGCGGGGAGCCCCGCCTGAGGTGCCCTAAACACACTATGACCGCT
CCCGAAAAGCCCGTGAAACAAGAGGAAATGGCTGCCTTGGACGTGGATAGCGGCGGCGGCGGTGGCGGCGGCGGCGGCCACGGCGAGTAT
CTGCAGCAGCAGCAACAGCACGGAAACGGTGCGGTGGCGGCGGCAGCGGCGGCCCAGGACACTCAGCCGTCACCGCTCGCTCTGCTGGCC
GCTACCTGCAGCAAGATAGGGCCGCCATCGCCGGGCGACGACGAGGAGGAGGCGGCCGCCGCAGCCGGGGCCCCCGCCGCCGCCGGAGCG
ACAGGTGATTTGGCTTCTGCACAGTTAGGAGGAGCACCAAACCGATGGGAGGTTTTGTCAGCCACACCTACAACTATAAAAGATGAAGCT
GGTAATCTAGTCCAGATTCCAAGTGCTGCTACTTCAAGTGGGCAGTATGTTCTTCCCCTTCAGAATTTGCAGAATCAACAAATATTTTCC
GTTGCACCAGGATCAGATTCATCAAATGGTACAGTGTCCAGTGTTCAATATCAAGTGATACCACAGATCCAGTCAGCAGATGGTCAGCAG
GTTCAAATTGGTTTCACAGGCTCTTCAGATAATGGGGGTATAAATCAAGAAAGCAGTCAAATTCAGATCATTCCTGGCTCTAATCAAACC
TTACTTGCCTCTGGAACACCTTCTGCTAACATCCAGAATCTCATACCACAGACTGGTCAAGTCCAGGTTCAGGGAGTTGCAATTGGTGGT
TCATCTTTTCCTGGTCAAACCCAAGTAGTTGCTAATGTGCCTCTTGGTCTGCCAGGAAATATTACGTTTGTACCAATCAATAGTGTCGAT
CTAGATTCTTTGGGACTCTCGGGCAGTTCTCAGACAATGACTGCAGGCATTAATGCCGACGGACATTTGATAAACACAGGACAAGCTATG
GATAGTTCAGACAATTCAGAAAGGACTGGTGAGCGGGTTTCTCCTGATATTAATGAAACTAATACTGATACAGATTTATTTGTGCCAACA
TCCTCTTCATCACAGTTGCCTGTTACGATAGATAGTACAGGTATATTACAACAAAACACAAATAGCTTGACTACATCTAGTGGGCAGGTT
CATTCTTCAGATCTTCAGGGAAATTATATCCAGTCGCCTGTTTCTGAAGAGACACAGGCACAGAATATTCAGGTTTCTACAGCACAGCCT
GTTGTACAGCATCTACAACTTCAAGAGTCTCAGCAGCCAACCAGTCAAGCCCAAATTGTGCAAGGTATTACACCACAGACAATCCATGGT
GTGCAAGCCAGTGGTCAAAATATATCACAACAGGCTTTGCAAAATCTTCAGTTGCAGCTGAATCCTGGAACCTTTTTAATTCAGGCACAG
ACAGTGACCCCTTCTGGACAGGTAACTTGGCAAACGTTTCAAGTACAAGGGGTCCAGAACTTGCAGAATTTGCAAATACAGAATACTGCT
GCCCAACAAATAACTTTGACGCCTGTTCAAACCCTCACACTTGGTCAAGTTGCGGCAGGTGGAGCCTTCACTTCAACTCCAGTTAGTCTA
AGCACTGGTCAGTTGCCAAATCTACAAACAGTTACAGTGAACTCTATAGATTCTGCTGGTATACAGCTACATCCAGGAGAGAATGCTGAC
AGTCCTGCAGGTGCTTTTGAAGATGATGATATCACGCACGTTGAAGGAAGTGTAGATCCTATTCGAGATATAGAAATAATACATGAAGAG
CTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAGGTGGCTGTGAGAGGAGGAGATAAAAAACTAAAACCT
GAATATGATATAATGTGCAAAGTAAAATCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGATTGGAATGACAAAGAGATT
GAAGTGTTGAATAAACACTTATTTTTGACTTCAAAACCAATGGTCTACTTGGTTAATCTTTCTGAAAAAGACTACATTAGAAAGAAAAAC
AAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCTTTGGTCATTCCTTTTAGTGGGGCCTTGGAACTCAAGTTG
CAAGAATTGAGTGCTGAGGAGAGACAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATCATTAAGGCTGGGTTTGCA
GCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACTAAGGCTCCTCAGGCTGCA
GGAAAGATTCACACAGATTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAGGAAGGTTCTGAAAATGCA
GTCAAGGCTGCTGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAACACACCTCAA
CAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAAAATTTCTGA
AAACCAATGCGACAAATAAAGTTGGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATACTGTGTACCC
CCCCCCCCCCATGAAATGCAGGTTCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAGAAGCTTTTC
AGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATGTGGCTTGCT
CCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAAAACCAGCCTTGGTGTGTT
TGGGGATGTCTGTATTGACTGACTGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAATTTTAAGGCGTGTGTATG
ACACAGTAACTGGCAGTGTGGGGCAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAATAGTATACCAGGGATTTG
TCTCAAAAAAGTTAATTAATTTATAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATATGAGATAGGTGACTGACCA
CAAAGAAGAAAATTCTGTCTCAAAAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGAGGTTCACTTTTAATCTTT
CCTTTGAAATTATTAAATTGTAAAAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCAATGTGTATAAAAGTTCCT
ACACTGATTTTGAAATACTAAGATCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATATTTGAGAGCAGTCGAAGTG
GTAGTATGGGTAAGTTAAGCACTTCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGGTAATTTGGAGACCCTTTG
CCACTTAGCCTTCTCTTGTGATGATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTTTCCATTCCTGTGAGACCT
CCCTTCCTTGTCCTTGTCCTCTGCCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGATTCATACCCAGCCAGCCT
TTGCCTCTACTGTATCGCTTTGGGACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAAAGTTACCAAATGTAGCAC
TAGAGGCAAGAAAAGGGGTGATTTTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAGTCGTGAGTATAATTTAGA
AGCTCTCCAGTGAGTATTTTTTTAGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTACAGCAGAGAAATAAGAATA
AAACTAATGAAGGGTTTTTTAAAAGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAGTTTGCTGTGAAAAATCCT
TGTTATATCTATTTCTGTATTGGAGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAAGAATCAAATATCTTGCTT
TTGGGTCTTCTCCAAAGTAAATTGCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATCATGCAATTTTACTTTGTC
TAGCTTCTAATGTGGTAAATTGCACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGTAACTGCATTCATTAGGGG
CTGAAAATAAATGTTAAAAATGTTTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTTCATTTTCTCTGAAAGTCG
AGAATTCCAAGAACTGTTACATATAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGATAAAGTTAATATATTTTA
GGATGTTATGTAAATATTTTTGCATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTGAGGCCAGGCGTGGAGGCT
CACACCTATAATCCCAACACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCACAGGAGTTTGAGACCAGCCTGTGCAACATCATGAAA
CATCATCTCTACATAAAAAAATACATATATACAAAAATTAGCTGGGCATCATGGCACACACCTGTAGTCCCAGCTACTTAGGAGGCTGAG
ATGGGAGGATTGATCGATCGCTTGAGCCTGGGAGGTGGAGGCTACTGTGAGCCATGATCATGCCACTGCACTCCAGCCTGGGCAACAGAG
TGAGACCCTGTCTCCAAAGAGAAAGAGAAACTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAATAGCATTTAGTTGTGTTTT
ATCATGTTATCTTCATAACATGCATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAATAGTTTTTGTCGCTAACT
TAGTTATGAGTGAAGCCTCTGTTCACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATGATTCATCAATATTCCTAT
ATTAAAATTCCAGTTTGATGTTTGTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCCGTCTCCTTTCATTCAGAG
AGTCAGAGACGGTATCTCCTCCTCCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCTCTTTTTATTTTACAAGAG
ACTTGAGAAATGTCGGTTGTTCCTAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAGCTTGTAAAATACACTGTG

>In-frame_ENST00000310015_ENST00000284719_TCGA-AO-A12F-01A_SP3_chr2_174819601_-_OLA1_chr2_175006728_length(amino acids)=825AA_start in transcript=510_stop in transcript=2987
MRCPKHTMTAPEKPVKQEEMAALDVDSGGGGGGGGGHGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDEEEAAA
AAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNGTVSSVQYQVI
PQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGN
ITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNT
NSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTIHGVQASGQNISQQALQNLQLQL
NPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAG
IQLHPGENADSPAGAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEKVAVRGGDKKLKPEYDIMCKVKSWVIDQKKPVR
FYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALELKLQELSAEERQKYLEANMTQSA
LPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGSENAVKAAGKYRQQGRNYIVEDGD

--------------------------------------------------------------
>In-frame_ENST00000418194_ENST00000284719_TCGA-AO-A12F-01A_SP3_chr2_174819601_-_OLA1_chr2_175006728_length(transcript)=5616nt_BP=1819nt
CCTCGCCCGCCTGCCGCCTTTTTGTGCGCGTGTGAGTGTGGGCCCCAGCGTGCCCTCCCGGGGGTGGGTTCCGGGCGGAAGGCGGAGGCC
CGGCGCGCAGCCCGCCGCCCGCCTGCCCGCGGACCGGGGAGCCGGGGTGCTTGGAGCGGGGGACGCCAGGCGTGGGCTGGCGGCGGGACC
AGGAGGAGGAGGAGGAGGAGGAGGAGAGCGCGGGCTGGCGCTTGCCCGGGCGCAGTCGGCGGGGACCGAGTCGTACTTCCTGTGCGAAAG
GCGGCCCGACCCTAACCGCCACCCCCTCCCCCTGTCTCCCTCTCTGAACCCGCCCATTGGGGGTAGGACACTCAGCCGTCACCGCTCGCT
CTGCTGGCCGCTACCTGCAGCAAGATAGGGCCGCCATCGCCGGGCGACGACGAGGAGGAGGCGGCCGCCGCAGCCGGGGCCCCCGCCGCC
GCCGGAGCGACAGGTGATTTGGCTTCTGCACAGTTAGGAGGAGCACCAAACCGATGGGAGGTTTTGTCAGCCACACCTACAACTATAAAA
GATGAAGCTGGTAATCTAGTCCAGATTCCAAGTGCTGCTACTTCAAGTGGGCAGTATGTTCTTCCCCTTCAGAATTTGCAGAATCAACAA
ATATTTTCCGTTGCACCAGGATCAGATTCATCAAATGGTACAGTGTCCAGTGTTCAATATCAAGTGATACCACAGATCCAGTCAGCAGAT
GGTCAGCAGGTTCAAATTGGTTTCACAGGCTCTTCAGATAATGGGGGTATAAATCAAGAAAGCAGTCAAATTCAGATCATTCCTGGCTCT
AATCAAACCTTACTTGCCTCTGGAACACCTTCTGCTAACATCCAGAATCTCATACCACAGACTGGTCAAGTCCAGGTTCAGGGAGTTGCA
ATTGGTGGTTCATCTTTTCCTGGTCAAACCCAAGTAGTTGCTAATGTGCCTCTTGGTCTGCCAGGAAATATTACGTTTGTACCAATCAAT
AGTGTCGATCTAGATTCTTTGGGACTCTCGGGCAGTTCTCAGACAATGACTGCAGGCATTAATGCCGACGGACATTTGATAAACACAGGA
CAAGCTATGGATAGTTCAGACAATTCAGAAAGGACTGGTGAGCGGGTTTCTCCTGATATTAATGAAACTAATACTGATACAGATTTATTT
GTGCCAACATCCTCTTCATCACAGTTGCCTGTTACGATAGATAGTACAGGTATATTACAACAAAACACAAATAGCTTGACTACATCTAGT
GGGCAGGTTCATTCTTCAGATCTTCAGGGAAATTATATCCAGTCGCCTGTTTCTGAAGAGACACAGGCACAGAATATTCAGGTTTCTACA
GCACAGCCTGTTGTACAGCATCTACAACTTCAAGAGTCTCAGCAGCCAACCAGTCAAGCCCAAATTGTGCAAGGTATTACACCACAGACA
ATCCATGGTGTGCAAGCCAGTGGTCAAAATATATCACAACAGGCTTTGCAAAATCTTCAGTTGCAGCTGAATCCTGGAACCTTTTTAATT
CAGGCACAGACAGTGACCCCTTCTGGACAGGTAACTTGGCAAACGTTTCAAGTACAAGGGGTCCAGAACTTGCAGAATTTGCAAATACAG
AATACTGCTGCCCAACAAATAACTTTGACGCCTGTTCAAACCCTCACACTTGGTCAAGTTGCGGCAGGTGGAGCCTTCACTTCAACTCCA
GTTAGTCTAAGCACTGGTCAGTTGCCAAATCTACAAACAGTTACAGTGAACTCTATAGATTCTGCTGGTATACAGCTACATCCAGGAGAG
AATGCTGACAGTCCTGCAGGTGCTTTTGAAGATGATGATATCACGCACGTTGAAGGAAGTGTAGATCCTATTCGAGATATAGAAATAATA
CATGAAGAGCTTCAGCTTAAAGATGAGGAAATGATTGGGCCCATTATAGATAAACTAGAAAAGGTGGCTGTGAGAGGAGGAGATAAAAAA
CTAAAACCTGAATATGATATAATGTGCAAAGTAAAATCCTGGGTTATAGATCAAAAGAAACCTGTTCGCTTCTATCATGATTGGAATGAC
AAAGAGATTGAAGTGTTGAATAAACACTTATTTTTGACTTCAAAACCAATGGTCTACTTGGTTAATCTTTCTGAAAAAGACTACATTAGA
AAGAAAAACAAATGGTTGATAAAAATTAAAGAGTGGGTGGACAAGTATGACCCAGGTGCTTTGGTCATTCCTTTTAGTGGGGCCTTGGAA
CTCAAGTTGCAAGAATTGAGTGCTGAGGAGAGACAGAAGTATCTGGAAGCGAACATGACACAAAGTGCTTTGCCAAAGATCATTAAGGCT
GGGTTTGCAGCACTCCAACTAGAATACTTTTTCACTGCAGGCCCAGATGAAGTGCGTGCATGGACCATCAGGAAAGGGACTAAGGCTCCT
CAGGCTGCAGGAAAGATTCACACAGATTTTGAAAAGGGATTCATTATGGCTGAAGTAATGAAATACGAAGATTTTAAAGAGGAAGGTTCT
GAAAATGCAGTCAAGGCTGCTGGAAAGTACAGACAACAAGGCAGAAATTATATTGTTGAAGATGGAGATATTATCTTCTTCAAATTTAAC
ACACCTCAACAACCGAAGAAGAAATAAAATTTAGTTATTGCTCAGATAAACATACAACTTCCAAAAGGCATCTGATTTTTAAAAAATTAA
AATTTCTGAAAACCAATGCGACAAATAAAGTTGGGGAGATGGGAATCTTTGACAAACAAATTATTTTTATTTGTTTTAAAATTAAAATAC
TGTGTACCCCCCCCCCCCCATGAAATGCAGGTTCACTAAATGTGAACAGCTTTGCTTTTCACGTGATTAAGACCCTACTCCAAATTGTAG
AAGCTTTTCAGGAACCATATTACTCTCATGATACTTCATTAATCTCCATCATGTATGCCAAGCCTGACACATTTGACAGTGAGGACAATG
TGGCTTGCTCCTTTTTGAATCTACAGATAATGCATGTTTTACAGTACTCCAGATGTCTACACTCAATAAAACATTTGACAAAACCAGCCT
TGGTGTGTTTGGGGATGTCTGTATTGACTGACTGTGGTGTGCTGAATGCGATACGGCACCTGGTGGTTGCTGATTACAGAATTTTAAGGC
GTGTGTATGACACAGTAACTGGCAGTGTGGGGCAGCTGCAATTGTATCTTAAAAGTGAGTCTTTCATGGGAATCAGAAGAATAGTATACC
AGGGATTTGTCTCAAAAAAGTTAATTAATTTATAGATCAACATTTATTGAAAGATGATAGCAATGATATTATGAGGGATATGAGATAGGT
GACTGACCACAAAGAAGAAAATTCTGTCTCAAAAATTAAAGAATTTTGTTTGTTATTGTTGTTCTGACCATATTGAAAAGAGGTTCACTT
TTAATCTTTCCTTTGAAATTATTAAATTGTAAAAACTGACCCATTGATGTCTGGTGGGTTATGTTTTGCTTCAATTCAGCAATGTGTATA
AAAGTTCCTACACTGATTTTGAAATACTAAGATCAGACTTTGAAAATTTTAAAAATTCTTTCATTCTTACTTTTCAGATATTTGAGAGCA
GTCGAAGTGGTAGTATGGGTAAGTTAAGCACTTCTTAACATTGTAGCAGAAAATTCCAAAAGAAAGACTAGAACAAATTGGTAATTTGGA
GACCCTTTGCCACTTAGCCTTCTCTTGTGATGATGGCCTGAAAGCTCTCTCGGCCCTGAGCCTCCCTTTCTCTCCCATGTTTCCATTCCT
GTGAGACCTCCCTTCCTTGTCCTTGTCCTCTGCCCTTTTGTGCTCTTCTGTGATCACAGGACCATTTCCATGGAATGCAGATTCATACCC
AGCCAGCCTTTGCCTCTACTGTATCGCTTTGGGACTTTAAAGATGCAGAAGTATTAGAACACACACAAACTTAAAATGGAAAGTTACCAA
ATGTAGCACTAGAGGCAAGAAAAGGGGTGATTTTTTAAAGATTTGGCTATACTTAAGATATTTAAAGAGGATGAGGTTGAGTCGTGAGTA
TAATTTAGAAGCTCTCCAGTGAGTATTTTTTTAGTATCAAATAGTGATCTTCTTTTGCTAACATAAAAATGAGTAAACTACAGCAGAGAA
ATAAGAATAAAACTAATGAAGGGTTTTTTAAAAGAACTAAATAAAACAAATAAAACTAGGCTACAGGTATAGCTGACCAAGTTTGCTGTG
AAAAATCCTTGTTATATCTATTTCTGTATTGGAGTAATGTGTAGATTAGTGGATTGTTAGGGATTTCAGCAGTATAAGAAAGAATCAAAT
ATCTTGCTTTTGGGTCTTCTCCAAAGTAAATTGCATGGACTTCTTAAAGAAGTTTGAAATCAGTAAAAAGACATTAGGATCATGCAATTT
TACTTTGTCTAGCTTCTAATGTGGTAAATTGCACATTGTGCAACAGAACCATTAATAAAAGAAAGGAGTTAGTTTTGAGGTAACTGCATT
CATTAGGGGCTGAAAATAAATGTTAAAAATGTTTAATTTGGTTAGAAGTTCTACAACATTGTATGTACATATACAAAATTTCATTTTCTC
TGAAAGTCGAGAATTCCAAGAACTGTTACATATAATCATATATATGCCTATATCTAAACGTTTTCCCTCCTTTAATATTGATAAAGTTAA
TATATTTTAGGATGTTATGTAAATATTTTTGCATGTATCTGTAGCTCCATCTTAATCAAATTTATGGTTAAAAGAGATTTGAGGCCAGGC
GTGGAGGCTCACACCTATAATCCCAACACTTTGGGAGGCCGAGGTGGGAGGATCACTTGAGCACAGGAGTTTGAGACCAGCCTGTGCAAC
ATCATGAAACATCATCTCTACATAAAAAAATACATATATACAAAAATTAGCTGGGCATCATGGCACACACCTGTAGTCCCAGCTACTTAG
GAGGCTGAGATGGGAGGATTGATCGATCGCTTGAGCCTGGGAGGTGGAGGCTACTGTGAGCCATGATCATGCCACTGCACTCCAGCCTGG
GCAACAGAGTGAGACCCTGTCTCCAAAGAGAAAGAGAAACTTGAGAAGGCTTGTGCCCAAAGCTTGAAGAAAGATTGTAATAGCATTTAG
TTGTGTTTTATCATGTTATCTTCATAACATGCATTTTGCATATGGCTCAGAGCAGAGCCGGATCTCCCAAGGAAGCACAAATAGTTTTTG
TCGCTAACTTAGTTATGAGTGAAGCCTCTGTTCACTTATAACTTGCCAGTTTCATTGGTGGAATAAGTCCCCTTACTCATGATTCATCAA
TATTCCTATATTAAAATTCCAGTTTGATGTTTGTCTCTAGTTGTCTGTGTATAATATTTCCAAAGCTCCTTTGTAAACCCCGTCTCCTTT
CATTCAGAGAGTCAGAGACGGTATCTCCTCCTCCTGCCTCTTCTATTGTTCTGATTAGTCTACTTAAATTCACTTGATGCTCTTTTTATT
TTACAAGAGACTTGAGAAATGTCGGTTGTTCCTAATGGCAAACTACTTTAGCTGGGAAAATTCATTTCAACTTATTTTAAGCTTGTAAAA

>In-frame_ENST00000418194_ENST00000284719_TCGA-AO-A12F-01A_SP3_chr2_174819601_-_OLA1_chr2_175006728_length(amino acids)=758AA_start in transcript=360_stop in transcript=2636
MLAATCSKIGPPSPGDDEEEAAAAAGAPAAAGATGDLASAQLGGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSGQYVLPLQNLQNQQ
IFSVAPGSDSSNGTVSSVQYQVIPQIQSADGQQVQIGFTGSSDNGGINQESSQIQIIPGSNQTLLASGTPSANIQNLIPQTGQVQVQGVA
IGGSSFPGQTQVVANVPLGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLF
VPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQT
IHGVQASGQNISQQALQNLQLQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTP
VSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPAGAFEDDDITHVEGSVDPIRDIEIIHEELQLKDEEMIGPIIDKLEKVAVRGGDKK
LKPEYDIMCKVKSWVIDQKKPVRFYHDWNDKEIEVLNKHLFLTSKPMVYLVNLSEKDYIRKKNKWLIKIKEWVDKYDPGALVIPFSGALE
LKLQELSAEERQKYLEANMTQSALPKIIKAGFAALQLEYFFTAGPDEVRAWTIRKGTKAPQAAGKIHTDFEKGFIMAEVMKYEDFKEEGS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SP3-OLA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SP3-OLA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SP3-OLA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source