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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SPARC-HSP90B1 (FusionGDB2 ID:84907) |
Fusion Gene Summary for SPARC-HSP90B1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPARC-HSP90B1 | Fusion gene ID: 84907 | Hgene | Tgene | Gene symbol | SPARC | HSP90B1 | Gene ID | 6678 | 7184 |
| Gene name | secreted protein acidic and cysteine rich | heat shock protein 90 beta family member 1 | |
| Synonyms | BM-40|OI17|ON|ONT | ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1 | |
| Cytomap | 5q33.1 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin) | endoplasmin94 kDa glucose-regulated proteinendothelial cell (HBMEC) glycoproteinepididymis luminal protein 35epididymis secretory sperm binding protein Li 125mheat shock protein 90 kDa beta member 1heat shock protein 90kDa beta (Grp94), member 1hea | |
| Modification date | 20200329 | 20200320 | |
| UniProtAcc | SPARC | P14625 | |
| Ensembl transtripts involved in fusion gene | ENST00000231061, ENST00000537849, | ENST00000299767, | |
| Fusion gene scores | * DoF score | 39 X 30 X 11=12870 | 21 X 21 X 8=3528 |
| # samples | 47 | 25 | |
| ** MAII score | log2(47/12870*10)=-4.77520748654306 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(25/3528*10)=-3.81885056089543 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPARC [Title/Abstract] AND HSP90B1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SPARC(151054173)-HSP90B1(104341152), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | SPARC-HSP90B1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. SPARC-HSP90B1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. SPARC-HSP90B1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SPARC-HSP90B1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SPARC | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 |
| Hgene | SPARC | GO:0010595 | positive regulation of endothelial cell migration | 12867428 |
| Hgene | SPARC | GO:0016525 | negative regulation of angiogenesis | 12867428 |
| Hgene | SPARC | GO:0022604 | regulation of cell morphogenesis | 15389586 |
| Tgene | HSP90B1 | GO:0001666 | response to hypoxia | 15620698 |
| Tgene | HSP90B1 | GO:0031247 | actin rod assembly | 19000834 |
| Tgene | HSP90B1 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 19000834 |
| Tgene | HSP90B1 | GO:0071318 | cellular response to ATP | 19000834 |
| Fusion gene breakpoints across SPARC (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across HSP90B1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-AH-6549-01A | SPARC | chr5 | 151054173 | - | HSP90B1 | chr12 | 104341152 | + |
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Fusion Gene ORF analysis for SPARC-HSP90B1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000231061 | ENST00000299767 | SPARC | chr5 | 151054173 | - | HSP90B1 | chr12 | 104341152 | + |
| intron-3CDS | ENST00000537849 | ENST00000299767 | SPARC | chr5 | 151054173 | - | HSP90B1 | chr12 | 104341152 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for SPARC-HSP90B1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SPARC-HSP90B1 |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPARC | HSP90B1 |
| 664 | FUNCTION: Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). Has ATPase activity (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059). {ECO:0000250|UniProtKB:P08113, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:32272059}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for SPARC-HSP90B1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for SPARC-HSP90B1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SPARC-HSP90B1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB00615 | Rifabutin | Other/unknown | Small molecule | Approved|Investigational |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational | |
| Tgene | HSP90B1 | P14625 | DB09130 | Copper | Small molecule | Approved|Investigational |
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Related Diseases for SPARC-HSP90B1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPARC | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
| Hgene | SPARC | C0029434 | Osteogenesis Imperfecta | 2 | CTD_human;GENOMICS_ENGLAND |
| Hgene | SPARC | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| Hgene | SPARC | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Hgene | SPARC | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| Hgene | SPARC | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | SPARC | C0019158 | Hepatitis | 1 | CTD_human |
| Hgene | SPARC | C0020429 | Hyperalgesia | 1 | CTD_human |
| Hgene | SPARC | C0022658 | Kidney Diseases | 1 | CTD_human |
| Hgene | SPARC | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | SPARC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | SPARC | C0023931 | Lobstein Disease | 1 | CTD_human |
| Hgene | SPARC | C0024031 | Low Back Pain | 1 | CTD_human |
| Hgene | SPARC | C0026764 | Multiple Myeloma | 1 | CTD_human |
| Hgene | SPARC | C0026998 | Acute Myeloid Leukemia, M1 | 1 | CTD_human |
| Hgene | SPARC | C0027540 | Necrosis | 1 | CTD_human |
| Hgene | SPARC | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Hgene | SPARC | C0040034 | Thrombocytopenia | 1 | CTD_human |
| Hgene | SPARC | C0041948 | Uremia | 1 | CTD_human |
| Hgene | SPARC | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | SPARC | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | SPARC | C0158266 | Intervertebral Disc Degeneration | 1 | CTD_human |
| Hgene | SPARC | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Hgene | SPARC | C0239946 | Fibrosis, Liver | 1 | CTD_human |
| Hgene | SPARC | C0268363 | Osteogenesis imperfecta type IV (disorder) | 1 | ORPHANET |
| Hgene | SPARC | C0423682 | Low Back Pain, Mechanical | 1 | CTD_human |
| Hgene | SPARC | C0423689 | Low Back Pain, Posterior Compartment | 1 | CTD_human |
| Hgene | SPARC | C0458247 | Allodynia | 1 | CTD_human |
| Hgene | SPARC | C0577660 | Low Back Pain, Postural | 1 | CTD_human |
| Hgene | SPARC | C0751211 | Hyperalgesia, Primary | 1 | CTD_human |
| Hgene | SPARC | C0751212 | Hyperalgesia, Secondary | 1 | CTD_human |
| Hgene | SPARC | C0751213 | Tactile Allodynia | 1 | CTD_human |
| Hgene | SPARC | C0751214 | Hyperalgesia, Thermal | 1 | CTD_human |
| Hgene | SPARC | C0751648 | Recurrent Low Back Pain | 1 | CTD_human |
| Hgene | SPARC | C0919267 | ovarian neoplasm | 1 | CTD_human |
| Hgene | SPARC | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
| Hgene | SPARC | C1879321 | Acute Myeloid Leukemia (AML-M2) | 1 | CTD_human |
| Hgene | SPARC | C2717759 | Degenerative Intervertebral Discs | 1 | CTD_human |
| Hgene | SPARC | C2936719 | Mechanical Allodynia | 1 | CTD_human |
| Hgene | SPARC | C4225301 | OSTEOGENESIS IMPERFECTA, TYPE XVII | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Tgene | HSP90B1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Tgene | HSP90B1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | HSP90B1 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
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