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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SPATA13-MIPEP (FusionGDB2 ID:84952)

Fusion Gene Summary for SPATA13-MIPEP

Fusion gene summary

Fusion gene information	Fusion gene name: SPATA13-MIPEP
	Fusion gene ID: 84952
		Hgene	Tgene
	Gene symbol	SPATA13	MIPEP
	Gene ID	221178	4285
	Gene name	spermatogenesis associated 13	mitochondrial intermediate peptidase
	Synonyms	ARHGEF29\|ASEF2	COXPD31\|HMIP\|MIP
	Cytomap	13q12.12	13q12.12
	Type of gene	protein-coding	protein-coding
	Description	spermatogenesis-associated protein 13APC-stimulated guanine nucleotide exchange factor 2adenomatous polyposis coli stimulated exchange factor 2	mitochondrial intermediate peptidase
	Modification date	20200313	20200313
	UniProtAcc	.	Q99797
	Ensembl transtripts involved in fusion gene	ENST00000424834, ENST00000382108, ENST00000382095, ENST00000474317, ENST00000399949, ENST00000409126, ENST00000343003,	ENST00000382172, ENST00000469167,
Fusion gene scores	* DoF score	9 X 5 X 6=270	10 X 7 X 7=490
	# samples	9	14
	** MAII score	log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/490*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SPATA13 [Title/Abstract] AND MIPEP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SPATA13(24798720)-MIPEP(24384063), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SPATA13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MIPEP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-5497-01A	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-

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Fusion Gene ORF analysis for SPATA13-MIPEP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000424834	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
5CDS-intron	ENST00000424834	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
In-frame	ENST00000382108	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
5CDS-intron	ENST00000382108	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-3CDS	ENST00000382095	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-intron	ENST00000382095	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
3UTR-3CDS	ENST00000474317	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
3UTR-intron	ENST00000474317	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-3CDS	ENST00000399949	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-intron	ENST00000399949	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-3CDS	ENST00000409126	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-intron	ENST00000409126	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-3CDS	ENST00000343003	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-
intron-intron	ENST00000343003	ENST00000469167	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000424834

SPATA13

chr13

24798720

ENST00000382172

MIPEP

chr13

24384063

2774

2126

287

2614

775

ENST00000382108

SPATA13

chr13

24798720

ENST00000382172

MIPEP

chr13

24384063

2623

1975

283

2463

726

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000424834	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-	0.0184256	0.98157436
ENST00000382108	ENST00000382172	SPATA13	chr13	24798720	+	MIPEP	chr13	24384063	-	0.013788004	0.986212

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Fusion Genomic Features for SPATA13-MIPEP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPATA13-MIPEP

Go to
FGviewer for the breakpoints of chr13:24798720-chr13:24384063
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MIPEP Q99797
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

20_23

597.0

Compositional bias

Note=Poly-Arg

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

20_23

653.0

Compositional bias

Note=Poly-Arg

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

20_23

575.0

Compositional bias

Note=Poly-Arg

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

147_206

597.0

Domain

SH3

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

240_424

597.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

455_561

597.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

147_206

653.0

Domain

SH3

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

240_424

653.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

455_561

653.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

147_206

575.0

Domain

SH3

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

240_424

575.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

455_561

575.0

Domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

561_652

597.0

Region

Note=C-terminal tail

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000343003

98_150

597.0

Region

Note=ABR (APC-binding region) domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

561_652

653.0

Region

Note=C-terminal tail

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000382095

98_150

653.0

Region

Note=ABR (APC-binding region) domain

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

561_652

575.0

Region

Note=C-terminal tail

Hgene

SPATA13

chr13:24798720

chr13:24384063

ENST00000399949

98_150

575.0

Region

Note=ABR (APC-binding region) domain

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Fusion Gene Sequence for SPATA13-MIPEP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000424834_ENST00000382172_TCGA-EJ-5497-01A_SPATA13_chr13_24798720_+_MIPEP_chr13_24384063_length(transcript)=2774nt_BP=2126nt
GCGCACCCGGGACAGTTTCCAGTCGGCTTCTCCGTGACCTTCCTCCCCCTTCCAGCTCGGAGCGGGATGCTGGGATCCCTCCAAGGACCC
TCTGAGGACGTAGGAGGGATGCTGAGACAGGGCCAGCTTCAAACCTTGTCAAGCTCTGACAAGGGAAGATGAAGCCTAGTTCCAGCTAGG
GGTGACCTGTCTATCTGCATTTTTTGAGCTGCAGAGTGATGGGAGTCATATTCGCTGCCTGTGCAGCACCACAGGCCTGATGAAAATGAA
ATGGCAACACCGTGCAGATGGCAAAGCGTAGGCCTCACAAACATCCTGGCCGTGAAGAGCTTGTCTTCAAGAGTAGCTGGTGCAGAAACT
CGCCCGTGGCCACCCAGGAGCCCGATGTGCAAGGCAGGTGTGAGTGCCAGGACGGCATTCCTGGAGATGAAGGCCTGGAGCTGCGGTCTG
CGGACTCGGCAGTGCCCGTGGCCATGACCCAGGCTGCCGTGCGGCCCTGGGCACCCTGCCTGGAGAACATGACCACTGCCCCAAACGGCC
TCGGGCCAGGCCCCGCAGCCCCCTGTGCAGGCTCGGACCTGAAAGACGCCAAGATGGTGACCTCCCTTGCGTGTGGAAATGGAGTCTGTG
GCTGCAGCCCTGGTGGCGACACGGACACCCAGGAAGCCAAACTCAGCCCAGCCAAGCTTGTGCGCCTCTTTTCCACCAGTCGGAAGAGGA
CGGGTGCCCACCCCGAGCGGCCCCACTCCATGGTCCTGGTGGGGAACTCCTCCACATGGAACACCCTCGCCTCCTTCCGGAAAATGGGAT
CCTTTAAGAAACTGAAGTCCTCAGTCCTGAAAGGAATTCAGAGCCGAGAGGGGTCAAATGCCTGTTCAAAGGGAGAGGCTTCGGAGCATG
GCCTGGGAAAGTCCATCCCAAATGGCGCTGTCCCAGGAGCCCAGGCAAGCAGGGGCTCCCCCTTAGCACCGGGACCAGCATGTGGTGCCC
TCAGGCCAGCAGAGTGGGGCACATTGGATGGCTCCGACCTCGAGGACACGGACGATGCCTTCCAGCGGAGCACACACCGCTCCCGCAGCC
TCCGCAGAGCCTACGGCCTGGGCCGCATCTGCCTGCTGGATGCGCCCCAGAACCATGCGACACCCACGATAGCCACTGGCCAGGTGCCCG
CCGTGTGTGAGATTCTCGTGAGGGACCCTGAAAACAACAGCATGGGCTACAGGAGGAGCAAGAGCACGGACAATCTTGCCTTTCTGAAGA
AGAGCTCCTTTAAGCGGAAGTCCACCTCCAATCTTGCAGACCTCAGGACGGCCCATGACGCACGGGTACCACAGAGGACCCTGAGCAGTT
CCTCCACTGACTCCCAAAAGCTTGGGTCAGGAAGGACCAAACGCTGGAGGAGCCCGATAAGGGCCAAGGACTTTGACAGAGTCTTCAAAC
TTGTGAGCAATGTGACTGAGGCTGCCTGGAGGAGGGAGAGTCCTAGGAGTGGGGCCCCATCCCCTGGAGAGGCCAGCCTGAGACTTCAGG
CACACAGCCGGCTGCATGACGACTACTCCCGCCGCGTCTCCAGGAGCACTGAGCAGGACAGCAGGCGGGGCGGGGCGGTCATGCATGGGA
CCACTGCAACCTGCACCGTGGCCCCCGGTTTCGGCTCAGCCACCTCTAAGGGGCCCCACCTAGACGCTGACACTGCCGTATTTCCTCTTG
AAACCAAAAGTTCCTGGGCGGTGGAAAGCGACAGTTCCTGCACTTGCAGCTCTTTGCCAAGCCCGATTGTCCAGGATGTGTTGAGCAAAG
ACTCCTGTGACCCAAACGCTGGCAGCCAGTTGACATTTGACCCTGAGCAGCCTCCCACCCCTCTAAGGCCCACCACACCCAAGCCCCAGA
GCCCTCAGAGCCCCCAGAGCCCCGGGGCAGGAAGTGCCAGCTGTCACAGCAATCACAGTGCCCTGTCCGCGAATTCAGAGGAAAGTGAAG
GAAGGGCAGAAGAGCCTGCTCAGAGAGAGCCAGGGCCTGTGTCCTTGCAGGATCCCCTGGAAGCCACACATGGTGATGAGGGCAGCAAGG
ACCTTCTGGTGAACATTGGTGTGGCAGCCGGCCCAGAAGAAAAGGAGAAGGAGGAGCCACTGCCAAAAAATATGGTGTCTCGTCTTTGTG
AATCTAAAAAGGTTTGTGCTGCAGCTGATATGCAACTTCAGGTCTTTTATGCCACTCTGGATCAAATCTACCATGGGAAGCATCCCCTGA
GGAATTCAACCACAGACATTCTCAAGGAAACACAAGAGAAATTCTATGGCCTACCATATGTTCCAAATACTGCCTGGCAGCTGCGATTCA
GCCACCTCGTGGGGTATGGTGCTAGATATTACTCTTACCTCATGTCCAGAGCGGTCGCCTCCATGGTTTGGAAGGAGTGTTTTCTACAGG
ATCCTTTCAACAGGGCTGCCGGGGAGCGCTATCGCAGGGAGATGCTGGCCCACGGTGGAGGCAGGGAGCCCATGCTCATGGTTGAAGGTA
TGCTTCAGAAGTGTCCTTCTGTTGATGACTTCGTAAGTGCCCTCGTTTCCGACTTGGATCTGGACTTCGAAACTTTCCTCATGGATTCTG
AATAAAAGAAACACTCTACACCTCTTAAATCAAGGTCATGTAGATAATGACTTTGTTATAAATGCTACAGCTGTGAGAGCTTGTTTCTGA

>In-frame_ENST00000424834_ENST00000382172_TCGA-EJ-5497-01A_SPATA13_chr13_24798720_+_MIPEP_chr13_24384063_length(amino acids)=775AA_start in transcript=287_stop in transcript=2614
MAKRRPHKHPGREELVFKSSWCRNSPVATQEPDVQGRCECQDGIPGDEGLELRSADSAVPVAMTQAAVRPWAPCLENMTTAPNGLGPGPA
APCAGSDLKDAKMVTSLACGNGVCGCSPGGDTDTQEAKLSPAKLVRLFSTSRKRTGAHPERPHSMVLVGNSSTWNTLASFRKMGSFKKLK
SSVLKGIQSREGSNACSKGEASEHGLGKSIPNGAVPGAQASRGSPLAPGPACGALRPAEWGTLDGSDLEDTDDAFQRSTHRSRSLRRAYG
LGRICLLDAPQNHATPTIATGQVPAVCEILVRDPENNSMGYRRSKSTDNLAFLKKSSFKRKSTSNLADLRTAHDARVPQRTLSSSSTDSQ
KLGSGRTKRWRSPIRAKDFDRVFKLVSNVTEAAWRRESPRSGAPSPGEASLRLQAHSRLHDDYSRRVSRSTEQDSRRGGAVMHGTTATCT
VAPGFGSATSKGPHLDADTAVFPLETKSSWAVESDSSCTCSSLPSPIVQDVLSKDSCDPNAGSQLTFDPEQPPTPLRPTTPKPQSPQSPQ
SPGAGSASCHSNHSALSANSEESEGRAEEPAQREPGPVSLQDPLEATHGDEGSKDLLVNIGVAAGPEEKEKEEPLPKNMVSRLCESKKVC
AAADMQLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRA

--------------------------------------------------------------
>In-frame_ENST00000382108_ENST00000382172_TCGA-EJ-5497-01A_SPATA13_chr13_24798720_+_MIPEP_chr13_24384063_length(transcript)=2623nt_BP=1975nt
GTGTGCTGCCGCGGCGCGGGAGGAGAGTGTGCGTTGCGCTTTCTCCCGCGATCGCCCTGCCGGTCGCTAGCTCCGAGGGCGCGCACTGGA
TCCCAGGCTCCTCCGAGAGTGCGGCGACCTCGGGGCTCCGCCGGCACCGGAGGTGGCTCTGAGGGCAGGGACGTGTTGGACACGCTGACT
TTGTAGGCTCCGCCAAGAGGCGCCGCAGGAGCCCGTGGCCACCCAGGAGCCCGATGTGCAAGGCAGGTGTGAGTGCCAGGACGGCATTCC
TGGAGATGAAGGCCTGGAGCTGCGGTCTGCGGACTCGGCAGTGCCCGTGGCCATGACCCAGGCTGCCGTGCGGCCCTGGGCACCCTGCCT
GGAGAACATGACCACTGCCCCAAACGGCCTCGGGCCAGGCCCCGCAGCCCCCTGTGCAGGCTCGGACCTGAAAGACGCCAAGATGGTGAC
CTCCCTTGCGTGTGGAAATGGAGTCTGTGGCTGCAGCCCTGGTGGCGACACGGACACCCAGGAAGCCAAACTCAGCCCAGCCAAGCTTGT
GCGCCTCTTTTCCACCAGTCGGAAGAGGACGGGTGCCCACCCCGAGCGGCCCCACTCCATGGTCCTGGTGGGGAACTCCTCCACATGGAA
CACCCTCGCCTCCTTCCGGAAAATGGGATCCTTTAAGAAACTGAAGTCCTCAGTCCTGAAAGGAATTCAGAGCCGAGAGGGGTCAAATGC
CTGTTCAAAGGGAGAGGCTTCGGAGCATGGCCTGGGAAAGTCCATCCCAAATGGCGCTGTCCCAGGAGCCCAGGCAAGCAGGGGCTCCCC
CTTAGCACCGGGACCAGCATGTGGTGCCCTCAGGCCAGCAGAGTGGGGCACATTGGATGGCTCCGACCTCGAGGACACGGACGATGCCTT
CCAGCGGAGCACACACCGCTCCCGCAGCCTCCGCAGAGCCTACGGCCTGGGCCGCATCTGCCTGCTGGATGCGCCCCAGAACCATGCGAC
ACCCACGATAGCCACTGGCCAGGTGCCCGCCGTGTGTGAGATTCTCGTGAGGGACCCTGAAAACAACAGCATGGGCTACAGGAGGAGCAA
GAGCACGGACAATCTTGCCTTTCTGAAGAAGAGCTCCTTTAAGCGGAAGTCCACCTCCAATCTTGCAGACCTCAGGACGGCCCATGACGC
ACGGGTACCACAGAGGACCCTGAGCAGTTCCTCCACTGACTCCCAAAAGCTTGGGTCAGGAAGGACCAAACGCTGGAGGAGCCCGATAAG
GGCCAAGGACTTTGACAGAGTCTTCAAACTTGTGAGCAATGTGACTGAGGCTGCCTGGAGGAGGGAGAGTCCTAGGAGTGGGGCCCCATC
CCCTGGAGAGGCCAGCCTGAGACTTCAGGCACACAGCCGGCTGCATGACGACTACTCCCGCCGCGTCTCCAGGAGCACTGAGCAGGACAG
CAGGCGGGGCGGGGCGGTCATGCATGGGACCACTGCAACCTGCACCGTGGCCCCCGGTTTCGGCTCAGCCACCTCTAAGGGGCCCCACCT
AGACGCTGACACTGCCGTATTTCCTCTTGAAACCAAAAGTTCCTGGGCGGTGGAAAGCGACAGTTCCTGCACTTGCAGCTCTTTGCCAAG
CCCGATTGTCCAGGATGTGTTGAGCAAAGACTCCTGTGACCCAAACGCTGGCAGCCAGTTGACATTTGACCCTGAGCAGCCTCCCACCCC
TCTAAGGCCCACCACACCCAAGCCCCAGAGCCCTCAGAGCCCCCAGAGCCCCGGGGCAGGAAGTGCCAGCTGTCACAGCAATCACAGTGC
CCTGTCCGCGAATTCAGAGGAAAGTGAAGGAAGGGCAGAAGAGCCTGCTCAGAGAGAGCCAGGGCCTGTGTCCTTGCAGGATCCCCTGGA
AGCCACACATGGTGATGAGGGCAGCAAGGACCTTCTGGTGAACATTGGTGTGGCAGCCGGCCCAGAAGAAAAGGAGAAGGAGGAGCCACT
GCCAAAAAATATGGTGTCTCGTCTTTGTGAATCTAAAAAGGTTTGTGCTGCAGCTGATATGCAACTTCAGGTCTTTTATGCCACTCTGGA
TCAAATCTACCATGGGAAGCATCCCCTGAGGAATTCAACCACAGACATTCTCAAGGAAACACAAGAGAAATTCTATGGCCTACCATATGT
TCCAAATACTGCCTGGCAGCTGCGATTCAGCCACCTCGTGGGGTATGGTGCTAGATATTACTCTTACCTCATGTCCAGAGCGGTCGCCTC
CATGGTTTGGAAGGAGTGTTTTCTACAGGATCCTTTCAACAGGGCTGCCGGGGAGCGCTATCGCAGGGAGATGCTGGCCCACGGTGGAGG
CAGGGAGCCCATGCTCATGGTTGAAGGTATGCTTCAGAAGTGTCCTTCTGTTGATGACTTCGTAAGTGCCCTCGTTTCCGACTTGGATCT
GGACTTCGAAACTTTCCTCATGGATTCTGAATAAAAGAAACACTCTACACCTCTTAAATCAAGGTCATGTAGATAATGACTTTGTTATAA
ATGCTACAGCTGTGAGAGCTTGTTTCTGATTTCATTGTTCGCTTCTGTAATTCTGAAAAACTTTAAACTGGTAGAACTTGGAATAAATAA

>In-frame_ENST00000382108_ENST00000382172_TCGA-EJ-5497-01A_SPATA13_chr13_24798720_+_MIPEP_chr13_24384063_length(amino acids)=726AA_start in transcript=283_stop in transcript=2463
MELRSADSAVPVAMTQAAVRPWAPCLENMTTAPNGLGPGPAAPCAGSDLKDAKMVTSLACGNGVCGCSPGGDTDTQEAKLSPAKLVRLFS
TSRKRTGAHPERPHSMVLVGNSSTWNTLASFRKMGSFKKLKSSVLKGIQSREGSNACSKGEASEHGLGKSIPNGAVPGAQASRGSPLAPG
PACGALRPAEWGTLDGSDLEDTDDAFQRSTHRSRSLRRAYGLGRICLLDAPQNHATPTIATGQVPAVCEILVRDPENNSMGYRRSKSTDN
LAFLKKSSFKRKSTSNLADLRTAHDARVPQRTLSSSSTDSQKLGSGRTKRWRSPIRAKDFDRVFKLVSNVTEAAWRRESPRSGAPSPGEA
SLRLQAHSRLHDDYSRRVSRSTEQDSRRGGAVMHGTTATCTVAPGFGSATSKGPHLDADTAVFPLETKSSWAVESDSSCTCSSLPSPIVQ
DVLSKDSCDPNAGSQLTFDPEQPPTPLRPTTPKPQSPQSPQSPGAGSASCHSNHSALSANSEESEGRAEEPAQREPGPVSLQDPLEATHG
DEGSKDLLVNIGVAAGPEEKEKEEPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTA
WQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPATA13-MIPEP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SPATA13-MIPEP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SPATA13-MIPEP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	MIPEP	C4310661	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 31	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT