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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPECC1-TMEM11 (FusionGDB2 ID:85083)

Fusion Gene Summary for SPECC1-TMEM11

check button Fusion gene summary
Fusion gene informationFusion gene name: SPECC1-TMEM11
Fusion gene ID: 85083
HgeneTgene
Gene symbol

SPECC1

TMEM11

Gene ID

92521

8834

Gene namesperm antigen with calponin homology and coiled-coil domains 1transmembrane protein 11
SynonymsCYTSB|HCMOGT-1|HCMOGT1|NSPC17orf35|PM1|PMI
Cytomap

17p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptioncytospin-BNSP5cytokinesis and spindle organization Bnuclear structure protein 5sperm antigen HCMOGT-1sperm antigen with calponin-like and coiled coil domains 1structure protein NSP5a3astructure protein NSP5a3bstructure protein NSP5b3astructure prtransmembrane protein 11, mitochondrialputative receptor protein
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000472876, ENST00000395527, 
ENST00000395529, ENST00000261503, 
ENST00000395530, ENST00000536879, 
ENST00000395522, ENST00000395525, 
ENST00000584527, 		ENST00000317635, 
ENST00000584432, 
Fusion gene scores* DoF score11 X 11 X 3=3634 X 2 X 3=24
# samples 114
** MAII scorelog2(11/363*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SPECC1 [Title/Abstract] AND TMEM11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPECC1(20059549)-TMEM11(21102153), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SPECC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TMEM11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0EY-01ASPECC1chr17

20059549

+TMEM11chr17

21102153

-
ChimerDB4BRCATCGA-A2-A0EYSPECC1chr17

20059549

+TMEM11chr17

21102153

-
ChimerDB4BRCATCGA-A2-A0EY-01ASPECC1chr17

20059549

+TMEM11chr17

21102153

-
ChimerDB4BRCATCGA-A2-A0EY-01ASPECC1chr17

20059549

-TMEM11chr17

21102153

-


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Fusion Gene ORF analysis for SPECC1-TMEM11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000472876ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-5UTRENST00000472876ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-3CDSENST00000395527ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-5UTRENST00000395527ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-3CDSENST00000395529ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-5UTRENST00000395529ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-3CDSENST00000261503ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-5UTRENST00000261503ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
In-frameENST00000395530ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
5CDS-5UTRENST00000395530ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
5UTR-3CDSENST00000536879ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
5UTR-5UTRENST00000536879ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
In-frameENST00000395522ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
5CDS-5UTRENST00000395522ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
In-frameENST00000395525ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
5CDS-5UTRENST00000395525ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-3CDSENST00000584527ENST00000317635SPECC1chr17

20059549

+TMEM11chr17

21102153

-
intron-5UTRENST00000584527ENST00000584432SPECC1chr17

20059549

+TMEM11chr17

21102153

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395530SPECC1chr1720059549+ENST00000317635TMEM11chr1721102153-180924857764235
ENST00000395522SPECC1chr1720059549+ENST00000317635TMEM11chr1721102153-171515492670192
ENST00000395525SPECC1chr1720059549+ENST00000317635TMEM11chr1721102153-170914886664192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395530ENST00000317635SPECC1chr1720059549+TMEM11chr1721102153-0.316862310.68313766
ENST00000395522ENST00000317635SPECC1chr1720059549+TMEM11chr1721102153-0.580696760.41930327
ENST00000395525ENST00000317635SPECC1chr1720059549+TMEM11chr1721102153-0.359830380.6401696

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Fusion Genomic Features for SPECC1-TMEM11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPECC1-TMEM11


check button Go to

FGviewer for the breakpoints of chr17:20059549-chr17:21102153

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM11chr17:20059549chr17:21102153ENST0000031763502107_12420.666666666666668193.0TransmembraneHelical
TgeneTMEM11chr17:20059549chr17:21102153ENST000003176350284_10020.666666666666668193.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPECC1chr17:20059549chr17:21102153ENST00000261503+115579_77301069.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395522+16579_77313.333333333333334903.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395525+16579_77313.333333333333334710.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395527+115579_77301069.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395529+18579_7730791.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395530+113579_77313.333333333333334988.0Coiled coilOntology_term=ECO:0000255
HgeneSPECC1chr17:20059549chr17:21102153ENST00000261503+115260_37201069.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395522+16260_37213.333333333333334903.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395525+16260_37213.333333333333334710.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395527+115260_37201069.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395529+18260_3720791.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395530+113260_37213.333333333333334988.0Compositional biasNote=Ser-rich
HgeneSPECC1chr17:20059549chr17:21102153ENST00000261503+115962_106701069.0DomainCalponin-homology (CH)
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395522+16962_106713.333333333333334903.0DomainCalponin-homology (CH)
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395525+16962_106713.333333333333334710.0DomainCalponin-homology (CH)
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395527+115962_106701069.0DomainCalponin-homology (CH)
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395529+18962_10670791.0DomainCalponin-homology (CH)
HgeneSPECC1chr17:20059549chr17:21102153ENST00000395530+113962_106713.333333333333334988.0DomainCalponin-homology (CH)


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Fusion Gene Sequence for SPECC1-TMEM11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000395530_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(transcript)=1809nt_BP=248nt
GATGCAGATGAGGGGGCGGGGCCCACGGGCGCGGGAGAGCAGCGGCTCCGCCGGCAGCTGCTGGGAACTGGAAGGCGCCCGGTCCTTTCT
TTGACTGGAGCGGACCCGCCGGACGCAACCGCCTCGCCAGCCGGAGCCAGCGCGAGCTCGGCACGGTGGACACCCGGTCCGAGGCCGGCA
AGCCGGCTGGTGCCCGAGTCGGCCAAGCATGGGCAACCACTCAGGACGGCCCGAGGATCCGGAACCAGGGTGAGCTTGTCGGCCACAGAC
TGCTACATTGTGCATGAGATCTACAATGGGGAGAATGCCCAAGACCAGTTTGAGTACGAGCTGGAGCAGGCCCTGGAAGCCCAGTACAAG
TACATTGTGATTGAGCCCACTCGCATTGGCGACGAGACAGCCCGCTGGATCACCGTGGGCAACTGCCTGCACAAGACGGCCGTGCTGGCG
GGCACCGCCTGCCTCTTCACCCCGTTGGCGCTGCCCTTAGATTATTCCCACTACATTTCCCTGCCCGCTGGTGTGCTGAGCCTGGCCTGC
TGCACCCTCTATGGGATCTCCTGGCAGTTTGACCCTTGCTGCAAGTACCAAGTGGAGTACGACGCCTATAAACTGTCGCGCCTGCCTCTG
CACACACTCACCTCCTCCACCCCGGTGGTGCTGGTCCGGAAGGACGACCTGCACAGAAAGAGACTGCACAACACGATAGCACTGGCCGCC
CTGGTGTACTGTGTAAAGAAGATTTACGAACTCTATGCCGTATGATTTCAGTAGAACAGGGAGCGAAGCAAAACCACCCGGCCCACAAGA
GACAACAGAGTATTCAGATCGCCACACTCTGTGAGGCAGCAGAGCCTGGGCAGGTGTTTGGCTTAGTATTTGTTATTTTTAAAAAATAAC
AGATCACGGGTGTACCCAGGGTTTTTCAGCTCATTACACTAAGATGTGGATTTCCATAACCCAAGAGGGGGGTCTGAGGCTGTGGAAGTC
CGACTGGGCAGTGGAATGCTGATGGAGGCAGACGCTGCCGAGGGGGTGTGGACGTGCTTTGGGGGAGGTCTTTAAGTCTATTGTTTAACT
GTACCATCCAGAGCCCACCAGAAGCTATTGATCATTAAAATTATGAGAATTTCAACTCCCGCTGTTCTCTCTTTCCATGACTGCCCGCAG
CTGCTGCTGCACATCTGCTCTGGGTGGCGGCTTGCACATGGAAGGAGCAGGTGCCATGGTAGCCACCCTGCCCTGCTCCTAGCTGCGGCC
CAGTGTTACCACTTACAGCGACGACAAGCCTAGATCCAAGGTAGTCCTGGGGCCAAACCCCGCCCAGGAGCAGTCTCCTGGCTCACCTTG
GCCTCATCATTCCGAAGGCCATCACTGCCACCATGCTGTTCAGGAACATGGTAGGATAAGGTGACGAGGCTTGGAGGCCTTTGGGTGTCC
ACTTGAGTTCACGTGGGGAACTCTGGGCTCCAGGATCGCTCTTCAGAGATCTGAACACCTGTGTTTTCTTTGAAGCACCAAAACTCTTCC
TACTGTGGACCATGAGTTTATTAACCCATTGCCCTAGGCTGACAGAAGAGCCCTCGGAGCAATCTTGGAAGCACCCCCTGGCCTCAGTGC
TCGCTGTTCCACAGGAGCCAAGCCGGTGCTTCTCCCTCACACCAGAAGGTAGACTGTGTCACCTGCCACATTTCCTCTAAGGCAGGGGTG
GCCAATCTTGACTTCCCTGTGCCACATTGGAAAAAGAATTGTCTTGGACCACACATAAAATACACTAACGACAGCTGATGAGCTAAAAAA

>In-frame_ENST00000395530_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(amino acids)=235AA_start in transcript=57_stop in transcript=764
MLGTGRRPVLSLTGADPPDATASPAGASASSARWTPGPRPASRLVPESAKHGQPLRTARGSGTRVSLSATDCYIVHEIYNGENAQDQFEY
ELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVE

--------------------------------------------------------------
>In-frame_ENST00000395522_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(transcript)=1715nt_BP=154nt
CTGGAGCGGACCCGCCGGACGCAACCGCCTCGCCAGCCGGAGCCAGCGCGAGCTCGGCACGGTGGACACCCGGTCCGAGGCCGGCAAGCC
GGCTGGTGCCCGAGTCGGCCAAGCATGGGCAACCACTCAGGACGGCCCGAGGATCCGGAACCAGGGTGAGCTTGTCGGCCACAGACTGCT
ACATTGTGCATGAGATCTACAATGGGGAGAATGCCCAAGACCAGTTTGAGTACGAGCTGGAGCAGGCCCTGGAAGCCCAGTACAAGTACA
TTGTGATTGAGCCCACTCGCATTGGCGACGAGACAGCCCGCTGGATCACCGTGGGCAACTGCCTGCACAAGACGGCCGTGCTGGCGGGCA
CCGCCTGCCTCTTCACCCCGTTGGCGCTGCCCTTAGATTATTCCCACTACATTTCCCTGCCCGCTGGTGTGCTGAGCCTGGCCTGCTGCA
CCCTCTATGGGATCTCCTGGCAGTTTGACCCTTGCTGCAAGTACCAAGTGGAGTACGACGCCTATAAACTGTCGCGCCTGCCTCTGCACA
CACTCACCTCCTCCACCCCGGTGGTGCTGGTCCGGAAGGACGACCTGCACAGAAAGAGACTGCACAACACGATAGCACTGGCCGCCCTGG
TGTACTGTGTAAAGAAGATTTACGAACTCTATGCCGTATGATTTCAGTAGAACAGGGAGCGAAGCAAAACCACCCGGCCCACAAGAGACA
ACAGAGTATTCAGATCGCCACACTCTGTGAGGCAGCAGAGCCTGGGCAGGTGTTTGGCTTAGTATTTGTTATTTTTAAAAAATAACAGAT
CACGGGTGTACCCAGGGTTTTTCAGCTCATTACACTAAGATGTGGATTTCCATAACCCAAGAGGGGGGTCTGAGGCTGTGGAAGTCCGAC
TGGGCAGTGGAATGCTGATGGAGGCAGACGCTGCCGAGGGGGTGTGGACGTGCTTTGGGGGAGGTCTTTAAGTCTATTGTTTAACTGTAC
CATCCAGAGCCCACCAGAAGCTATTGATCATTAAAATTATGAGAATTTCAACTCCCGCTGTTCTCTCTTTCCATGACTGCCCGCAGCTGC
TGCTGCACATCTGCTCTGGGTGGCGGCTTGCACATGGAAGGAGCAGGTGCCATGGTAGCCACCCTGCCCTGCTCCTAGCTGCGGCCCAGT
GTTACCACTTACAGCGACGACAAGCCTAGATCCAAGGTAGTCCTGGGGCCAAACCCCGCCCAGGAGCAGTCTCCTGGCTCACCTTGGCCT
CATCATTCCGAAGGCCATCACTGCCACCATGCTGTTCAGGAACATGGTAGGATAAGGTGACGAGGCTTGGAGGCCTTTGGGTGTCCACTT
GAGTTCACGTGGGGAACTCTGGGCTCCAGGATCGCTCTTCAGAGATCTGAACACCTGTGTTTTCTTTGAAGCACCAAAACTCTTCCTACT
GTGGACCATGAGTTTATTAACCCATTGCCCTAGGCTGACAGAAGAGCCCTCGGAGCAATCTTGGAAGCACCCCCTGGCCTCAGTGCTCGC
TGTTCCACAGGAGCCAAGCCGGTGCTTCTCCCTCACACCAGAAGGTAGACTGTGTCACCTGCCACATTTCCTCTAAGGCAGGGGTGGCCA
ATCTTGACTTCCCTGTGCCACATTGGAAAAAGAATTGTCTTGGACCACACATAAAATACACTAACGACAGCTGATGAGCTAAAAAAAAAA

>In-frame_ENST00000395522_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(amino acids)=192AA_start in transcript=92_stop in transcript=670
MVPESAKHGQPLRTARGSGTRVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGT
ACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALV

--------------------------------------------------------------
>In-frame_ENST00000395525_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(transcript)=1709nt_BP=148nt
CGGACCCGCCGGACGCAACCGCCTCGCCAGCCGGAGCCAGCGCGAGCTCGGCACGGTGGACACCCGGTCCGAGGCCGGCAAGCCGGCTGG
TGCCCGAGTCGGCCAAGCATGGGCAACCACTCAGGACGGCCCGAGGATCCGGAACCAGGGTGAGCTTGTCGGCCACAGACTGCTACATTG
TGCATGAGATCTACAATGGGGAGAATGCCCAAGACCAGTTTGAGTACGAGCTGGAGCAGGCCCTGGAAGCCCAGTACAAGTACATTGTGA
TTGAGCCCACTCGCATTGGCGACGAGACAGCCCGCTGGATCACCGTGGGCAACTGCCTGCACAAGACGGCCGTGCTGGCGGGCACCGCCT
GCCTCTTCACCCCGTTGGCGCTGCCCTTAGATTATTCCCACTACATTTCCCTGCCCGCTGGTGTGCTGAGCCTGGCCTGCTGCACCCTCT
ATGGGATCTCCTGGCAGTTTGACCCTTGCTGCAAGTACCAAGTGGAGTACGACGCCTATAAACTGTCGCGCCTGCCTCTGCACACACTCA
CCTCCTCCACCCCGGTGGTGCTGGTCCGGAAGGACGACCTGCACAGAAAGAGACTGCACAACACGATAGCACTGGCCGCCCTGGTGTACT
GTGTAAAGAAGATTTACGAACTCTATGCCGTATGATTTCAGTAGAACAGGGAGCGAAGCAAAACCACCCGGCCCACAAGAGACAACAGAG
TATTCAGATCGCCACACTCTGTGAGGCAGCAGAGCCTGGGCAGGTGTTTGGCTTAGTATTTGTTATTTTTAAAAAATAACAGATCACGGG
TGTACCCAGGGTTTTTCAGCTCATTACACTAAGATGTGGATTTCCATAACCCAAGAGGGGGGTCTGAGGCTGTGGAAGTCCGACTGGGCA
GTGGAATGCTGATGGAGGCAGACGCTGCCGAGGGGGTGTGGACGTGCTTTGGGGGAGGTCTTTAAGTCTATTGTTTAACTGTACCATCCA
GAGCCCACCAGAAGCTATTGATCATTAAAATTATGAGAATTTCAACTCCCGCTGTTCTCTCTTTCCATGACTGCCCGCAGCTGCTGCTGC
ACATCTGCTCTGGGTGGCGGCTTGCACATGGAAGGAGCAGGTGCCATGGTAGCCACCCTGCCCTGCTCCTAGCTGCGGCCCAGTGTTACC
ACTTACAGCGACGACAAGCCTAGATCCAAGGTAGTCCTGGGGCCAAACCCCGCCCAGGAGCAGTCTCCTGGCTCACCTTGGCCTCATCAT
TCCGAAGGCCATCACTGCCACCATGCTGTTCAGGAACATGGTAGGATAAGGTGACGAGGCTTGGAGGCCTTTGGGTGTCCACTTGAGTTC
ACGTGGGGAACTCTGGGCTCCAGGATCGCTCTTCAGAGATCTGAACACCTGTGTTTTCTTTGAAGCACCAAAACTCTTCCTACTGTGGAC
CATGAGTTTATTAACCCATTGCCCTAGGCTGACAGAAGAGCCCTCGGAGCAATCTTGGAAGCACCCCCTGGCCTCAGTGCTCGCTGTTCC
ACAGGAGCCAAGCCGGTGCTTCTCCCTCACACCAGAAGGTAGACTGTGTCACCTGCCACATTTCCTCTAAGGCAGGGGTGGCCAATCTTG

>In-frame_ENST00000395525_ENST00000317635_TCGA-A2-A0EY-01A_SPECC1_chr17_20059549_+_TMEM11_chr17_21102153_length(amino acids)=192AA_start in transcript=86_stop in transcript=664
MVPESAKHGQPLRTARGSGTRVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGT
ACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPECC1-TMEM11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPECC1-TMEM11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPECC1-TMEM11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource