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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPEN-FBLIM1 (FusionGDB2 ID:85132)

Fusion Gene Summary for SPEN-FBLIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPEN-FBLIM1
Fusion gene ID: 85132
HgeneTgene
Gene symbol

SPEN

FBLIM1

Gene ID

64783

54751

Gene nameRNA binding motif protein 15filamin binding LIM protein 1
SynonymsOTT|OTT1|SPENCAL|FBLP-1|FBLP1
Cytomap

1p13.3

1p36.21

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1putative RNA-binding protein 15filamin-binding LIM protein 1CSX-associated LIMMIG2-interacting proteinmigfilinmitogen-inducible 2 interacting protein
Modification date2020031320200313
UniProtAcc.

Q8WUP2

Ensembl transtripts involved in fusion geneENST00000375759, ENST00000471538, 
ENST00000375771, ENST00000375766, 
ENST00000400773, ENST00000441801, 
ENST00000332305, ENST00000509138, 
Fusion gene scores* DoF score20 X 12 X 15=36005 X 7 X 6=210
# samples 318
** MAII scorelog2(31/3600*10)=-3.5376567859428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPEN [Title/Abstract] AND FBLIM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPEN(16203173)-FBLIM1(16090991), # samples:2
SPEN(16174645)-FBLIM1(16096904), # samples:2
SPEN(16203173)-FBLIM1(16101113), # samples:2
Anticipated loss of major functional domain due to fusion event.SPEN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SPEN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SPEN-FBLIM1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SPEN-FBLIM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPEN

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

26575292

HgeneSPEN

GO:0001510

RNA methylation

27602518

HgeneSPEN

GO:0009048

dosage compensation by inactivation of X chromosome

27602518

HgeneSPEN

GO:0045652

regulation of megakaryocyte differentiation

26575292

HgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689


check buttonFusion gene breakpoints across SPEN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBLIM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-K4-A3WV-01ASPENchr1

16203173

+FBLIM1chr1

16090991

+
ChimerDB4LIHCTCGA-RC-A6M3-01ASPENchr1

16174645

+FBLIM1chr1

16096904

+
ChimerDB4LIHCTCGA-5C-AAPDSPENchr1

16203173

+FBLIM1chr1

16101113

+
ChimerDB4LIHCTCGA-5C-AAPD-01ASPENchr1

16203173

-FBLIM1chr1

16101113

+
ChimerDB4BLCATCGA-K4-A3WV-01ASPENchr1

16203173

-FBLIM1chr1

16090991

+
ChimerDB4LIHCTCGA-RC-A6M3-01ASPENchr1

16174645

-FBLIM1chr1

16096904

+


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Fusion Gene ORF analysis for SPEN-FBLIM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000375759ENST00000375771SPENchr1

16203173

+FBLIM1chr1

16090991

+
5CDS-5UTRENST00000375759ENST00000375766SPENchr1

16203173

+FBLIM1chr1

16090991

+
5CDS-5UTRENST00000375759ENST00000400773SPENchr1

16203173

+FBLIM1chr1

16090991

+
5CDS-5UTRENST00000375759ENST00000441801SPENchr1

16203173

+FBLIM1chr1

16090991

+
5CDS-intronENST00000375759ENST00000332305SPENchr1

16203173

+FBLIM1chr1

16090991

+
5CDS-intronENST00000375759ENST00000509138SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-5UTRENST00000471538ENST00000375771SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-5UTRENST00000471538ENST00000375766SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-5UTRENST00000471538ENST00000400773SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-5UTRENST00000471538ENST00000441801SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-intronENST00000471538ENST00000332305SPENchr1

16203173

+FBLIM1chr1

16090991

+
3UTR-intronENST00000471538ENST00000509138SPENchr1

16203173

+FBLIM1chr1

16090991

+
Frame-shiftENST00000375759ENST00000375771SPENchr1

16174645

+FBLIM1chr1

16096904

+
Frame-shiftENST00000375759ENST00000375766SPENchr1

16174645

+FBLIM1chr1

16096904

+
Frame-shiftENST00000375759ENST00000400773SPENchr1

16174645

+FBLIM1chr1

16096904

+
Frame-shiftENST00000375759ENST00000441801SPENchr1

16174645

+FBLIM1chr1

16096904

+
Frame-shiftENST00000375759ENST00000332305SPENchr1

16174645

+FBLIM1chr1

16096904

+
5CDS-intronENST00000375759ENST00000509138SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-3CDSENST00000471538ENST00000375771SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-3CDSENST00000471538ENST00000375766SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-3CDSENST00000471538ENST00000400773SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-3CDSENST00000471538ENST00000441801SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-3CDSENST00000471538ENST00000332305SPENchr1

16174645

+FBLIM1chr1

16096904

+
intron-intronENST00000471538ENST00000509138SPENchr1

16174645

+FBLIM1chr1

16096904

+
Frame-shiftENST00000375759ENST00000375771SPENchr1

16203173

+FBLIM1chr1

16101113

+
Frame-shiftENST00000375759ENST00000375766SPENchr1

16203173

+FBLIM1chr1

16101113

+
Frame-shiftENST00000375759ENST00000400773SPENchr1

16203173

+FBLIM1chr1

16101113

+
In-frameENST00000375759ENST00000441801SPENchr1

16203173

+FBLIM1chr1

16101113

+
Frame-shiftENST00000375759ENST00000332305SPENchr1

16203173

+FBLIM1chr1

16101113

+
5CDS-intronENST00000375759ENST00000509138SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-3CDSENST00000471538ENST00000375771SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-3CDSENST00000471538ENST00000375766SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-3CDSENST00000471538ENST00000400773SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-3CDSENST00000471538ENST00000441801SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-3CDSENST00000471538ENST00000332305SPENchr1

16203173

+FBLIM1chr1

16101113

+
3UTR-intronENST00000471538ENST00000509138SPENchr1

16203173

+FBLIM1chr1

16101113

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375759SPENchr116203173+ENST00000441801FBLIM1chr116101113+17101085271184385

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375759ENST00000441801SPENchr116203173+FBLIM1chr116101113+0.0416411870.9583588

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Fusion Genomic Features for SPEN-FBLIM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPENchr116203173+FBLIM1chr116090993+9.49E-101
SPENchr116174645+FBLIM1chr116096903+5.64E-081
SPENchr116203173+FBLIM1chr116101112+6.58E-111
SPENchr116203173+FBLIM1chr116090993+9.49E-101
SPENchr116174645+FBLIM1chr116096903+5.64E-081
SPENchr116203173+FBLIM1chr116101112+6.58E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPEN-FBLIM1


check button Go to

FGviewer for the breakpoints of chr1:16203173-chr1:16101113

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FBLIM1

Q8WUP2

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455, ECO:0000269|PubMed:19074766}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315125_277293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3156_81293.66666666666673665.0DomainRRM 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000033230515181_242140.0277.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000033230515243_300140.0277.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000033230515301_370140.0277.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000037576659243_300237.0374.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000037576659301_370237.0374.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375771610243_300237.0374.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375771610301_370237.0374.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000040077337181_242140.0277.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000040077337243_300140.0277.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000040077337301_370140.0277.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000044180146243_300237.0375.0DomainLIM zinc-binding 2
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000044180146301_370237.0375.0DomainLIM zinc-binding 3
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000033230515276_373140.0277.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000037576659276_373237.0374.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375771610276_373237.0374.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000040077337276_373140.0277.0RegionNote=FERMT2-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000044180146276_373237.0375.0RegionNote=FERMT2-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151170_1191293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151408_1428293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151496_1529293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151592_1612293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151928_1944293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315688_715293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315977_1004293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315240_325293.66666666666673665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3152428_2520293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3153220_3482293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315616_810293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315624_697293.66666666666673665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3151_573293.66666666666673665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3152201_2707293.66666666666673665.0DomainNote=RID
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315335_415293.66666666666673665.0DomainRRM 2
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3153498_3664293.66666666666673665.0DomainSPOC
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315438_513293.66666666666673665.0DomainRRM 3
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+315517_589293.66666666666673665.0DomainRRM 4
TgeneFBLIM1chr1:16203173chr1:16101113ENST000003323051542_173140.0277.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:16203173chr1:16101113ENST000003757665942_173237.0374.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000037577161042_173237.0374.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:16203173chr1:16101113ENST000004007733742_173140.0277.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:16203173chr1:16101113ENST000004418014642_173237.0375.0Compositional biasNote=Pro-rich
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000037576659181_242237.0374.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375771610181_242237.0374.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST0000044180146181_242237.0375.0DomainLIM zinc-binding 1
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000332305151_70140.0277.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000332305151_85140.0277.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375766591_70237.0374.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000375766591_85237.0374.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:16203173chr1:16101113ENST000003757716101_70237.0374.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST000003757716101_85237.0374.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000400773371_70140.0277.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000400773371_85140.0277.0RegionNote=Intrinsically disordered
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000441801461_70237.0375.0RegionNote=Filamin-binding
TgeneFBLIM1chr1:16203173chr1:16101113ENST00000441801461_85237.0375.0RegionNote=Intrinsically disordered


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Fusion Gene Sequence for SPEN-FBLIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375759_ENST00000441801_TCGA-5C-AAPD_SPEN_chr1_16203173_+_FBLIM1_chr1_16101113_length(transcript)=1710nt_BP=1085nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGATATGGCCGCGTGGAAAGTGTCAAAATTCTTCCCAAGAGGGGATCTGAAGGAGGAGTGGCTGCCTTTGTGGAT
TTTGTGGACATCAAAAGTGCACAGAAAGCTCACAACTCGGTCAACAAAATGGGTGACAGAGACCTACGCACGGATTATAATGAACCAGGC
ACCATCCCGAGTGCTGCTCGGGGATTGGATGATACAGTTTCCATAGCATCTCGTAGTAGAGAGGTTTCTGGGTTCAGAGGAGGTGGTGGA
GGGCCTGCTTATGGTCCCCCACCGTCACTTCATGCACGAGAAGGACGTTATGAGCGGAGACTTGATGGGGCTTCAGATAACAGGGAGCGT
GCTTATGAACATAGTGCCTATGGACACCATGAACGGGGGACGGGAGGATTTGATCGGACAAGACATTACGATCAGGATTACTATAGAGAT
CCTCGAGAGCGGACTTTACAACATGGGCTCTATTACGCTTCTCGGAGTCGAAGTCCAAATCGCTTTGATGCTCATGACCCCCGATATGAA
CCTAGGGCTCGCGAGCAGTTTACACTGCCCAGTGTGGTACACAGGGATATCTACAGGGATGATATTACCCGGGAGGTACGAGGCAGAAGG
CCAGAGCGGAATTACCAGCACAGCAGGAGTCGGTCACCACATTCATCCCAGTCTAGAAATCAGTCTCCTCAGAGACTGGCTAGCCAAGCA
TCTAGACCCACAAGGTCCCCTAGCGGCAGCGGCTCTAGAAGTAGATCCTCCAGTAGTGATTCAATCAGCAGCAGCAGTAGTACCAGCAGT
GACAGGACACACTGGAGAGGTGCGGCAAGTGTGGCGAGGTGGTCCGGGACCACATCATCAGGGCCCTGGGCCAGGCCTTCCACCCCTCCT
GCTTCACGTGTGTGACCTGCGCCCGGTGCATTGGGGATGAGAGCTTTGCCCTGGGCAGCCAGAACGAGGTGTACTGCCTGGACGACTTCT
ACAGGTACGAGAAGGGTTTGTGCACTGGGTGGGGTGCAGGGACAGGGCGAGACCCAAGCAGGGTGAAGGAGCTGAGCTTGAGTCCTGGGT
GCTGGGCCAGAGTTTCCTGTCTACTGGTTTATTATAAAGAATATTACAGGGCTGGGCTGGGCGCGGTGGCTCACGCCTGTAATCCCAGCA
CTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGATCATCCTGGCTAACATGGTGAAACCCCGTCTCTACTAAAAATAC
AAAAAAAATTAGCCAGGCATGGTGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCTGGGAGGCA
GAGCTTGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGCAACAGAGTGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAA

>In-frame_ENST00000375759_ENST00000441801_TCGA-5C-AAPD_SPEN_chr1_16203173_+_FBLIM1_chr1_16101113_length(amino acids)=385AA_start in transcript=27_stop in transcript=1184
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRYGR
VESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPS
LHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTL
PSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDRTHWRGAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SPEN-FBLIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3152130_2464293.66666666666673665.0MSX2
HgeneSPENchr1:16203173chr1:16101113ENST00000375759+3152709_2870293.66666666666673665.0RBPSUH


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPEN-FBLIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPEN-FBLIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPENC0033578Prostatic Neoplasms1CTD_human
HgeneSPENC0376358Malignant neoplasm of prostate1CTD_human
TgeneFBLIM1C1864997Majeed syndrome1GENOMICS_ENGLAND