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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SPEN-PLEKHM2 (FusionGDB2 ID:85136)

Fusion Gene Summary for SPEN-PLEKHM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SPEN-PLEKHM2
Fusion gene ID: 85136
HgeneTgene
Gene symbol

SPEN

PLEKHM2

Gene ID

64783

23207

Gene nameRNA binding motif protein 15pleckstrin homology and RUN domain containing M2
SynonymsOTT|OTT1|SPENSKIP
Cytomap

1p13.3

1p36.21

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1putative RNA-binding protein 15pleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family M
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375759, ENST00000471538, 
ENST00000375799, ENST00000375793, 
ENST00000477849, 
Fusion gene scores* DoF score20 X 12 X 15=36003 X 6 X 7=126
# samples 317
** MAII scorelog2(31/3600*10)=-3.5376567859428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPEN [Title/Abstract] AND PLEKHM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSPEN(16203173)-PLEKHM2(16060292), # samples:2
Anticipated loss of major functional domain due to fusion event.SPEN-PLEKHM2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
SPEN-PLEKHM2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SPEN-PLEKHM2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SPEN-PLEKHM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPEN

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

26575292

HgeneSPEN

GO:0001510

RNA methylation

27602518

HgeneSPEN

GO:0009048

dosage compensation by inactivation of X chromosome

27602518

HgeneSPEN

GO:0045652

regulation of megakaryocyte differentiation

26575292

HgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689

TgenePLEKHM2

GO:1903527

positive regulation of membrane tubulation

18996344


check buttonFusion gene breakpoints across SPEN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PLEKHM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6528SPENchr1

16174645

+PLEKHM2chr1

16042731

+
ChimerDB4BRCATCGA-GM-A2DH-01ASPENchr1

16174645

+PLEKHM2chr1

16053687

+
ChimerDB4OVTCGA-23-1111-01ASPENchr1

16203173

+PLEKHM2chr1

16058384

+
ChimerDB4SARCTCGA-DX-AB2P-01ASPENchr1

16203173

+PLEKHM2chr1

16060292

+
ChimerDB4SARCTCGA-LI-A9QH-01ASPENchr1

16203173

-PLEKHM2chr1

16060292

+
ChimerDB4CESCTCGA-VS-A959-01ASPENchr1

16203173

-PLEKHM2chr1

16042732

+


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Fusion Gene ORF analysis for SPEN-PLEKHM2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000375759ENST00000375799SPENchr1

16174645

+PLEKHM2chr1

16042731

+
Frame-shiftENST00000375759ENST00000375793SPENchr1

16174645

+PLEKHM2chr1

16042731

+
5CDS-intronENST00000375759ENST00000477849SPENchr1

16174645

+PLEKHM2chr1

16042731

+
intron-3CDSENST00000471538ENST00000375799SPENchr1

16174645

+PLEKHM2chr1

16042731

+
intron-3CDSENST00000471538ENST00000375793SPENchr1

16174645

+PLEKHM2chr1

16042731

+
intron-intronENST00000471538ENST00000477849SPENchr1

16174645

+PLEKHM2chr1

16042731

+
In-frameENST00000375759ENST00000375799SPENchr1

16174645

+PLEKHM2chr1

16053687

+
In-frameENST00000375759ENST00000375793SPENchr1

16174645

+PLEKHM2chr1

16053687

+
5CDS-intronENST00000375759ENST00000477849SPENchr1

16174645

+PLEKHM2chr1

16053687

+
intron-3CDSENST00000471538ENST00000375799SPENchr1

16174645

+PLEKHM2chr1

16053687

+
intron-3CDSENST00000471538ENST00000375793SPENchr1

16174645

+PLEKHM2chr1

16053687

+
intron-intronENST00000471538ENST00000477849SPENchr1

16174645

+PLEKHM2chr1

16053687

+
In-frameENST00000375759ENST00000375799SPENchr1

16203173

+PLEKHM2chr1

16058384

+
In-frameENST00000375759ENST00000375793SPENchr1

16203173

+PLEKHM2chr1

16058384

+
5CDS-intronENST00000375759ENST00000477849SPENchr1

16203173

+PLEKHM2chr1

16058384

+
3UTR-3CDSENST00000471538ENST00000375799SPENchr1

16203173

+PLEKHM2chr1

16058384

+
3UTR-3CDSENST00000471538ENST00000375793SPENchr1

16203173

+PLEKHM2chr1

16058384

+
3UTR-intronENST00000471538ENST00000477849SPENchr1

16203173

+PLEKHM2chr1

16058384

+
In-frameENST00000375759ENST00000375799SPENchr1

16203173

+PLEKHM2chr1

16060292

+
In-frameENST00000375759ENST00000375793SPENchr1

16203173

+PLEKHM2chr1

16060292

+
5CDS-3UTRENST00000375759ENST00000477849SPENchr1

16203173

+PLEKHM2chr1

16060292

+
3UTR-3CDSENST00000471538ENST00000375799SPENchr1

16203173

+PLEKHM2chr1

16060292

+
3UTR-3CDSENST00000471538ENST00000375793SPENchr1

16203173

+PLEKHM2chr1

16060292

+
3UTR-3UTRENST00000471538ENST00000477849SPENchr1

16203173

+PLEKHM2chr1

16060292

+
Frame-shiftENST00000375759ENST00000375799SPENchr1

16203173

-PLEKHM2chr1

16042732

+
Frame-shiftENST00000375759ENST00000375793SPENchr1

16203173

-PLEKHM2chr1

16042732

+
5CDS-intronENST00000375759ENST00000477849SPENchr1

16203173

-PLEKHM2chr1

16042732

+
3UTR-3CDSENST00000471538ENST00000375799SPENchr1

16203173

-PLEKHM2chr1

16042732

+
3UTR-3CDSENST00000471538ENST00000375793SPENchr1

16203173

-PLEKHM2chr1

16042732

+
3UTR-intronENST00000471538ENST00000477849SPENchr1

16203173

-PLEKHM2chr1

16042732

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375759SPENchr116174645+ENST00000375799PLEKHM2chr116053687+30622873432226627
ENST00000375759SPENchr116174645+ENST00000375793PLEKHM2chr116053687+30622873432226627
ENST00000375759SPENchr116203173+ENST00000375799PLEKHM2chr116058384+25151085271679550
ENST00000375759SPENchr116203173+ENST00000375793PLEKHM2chr116058384+25151085271679550
ENST00000375759SPENchr116203173+ENST00000375799PLEKHM2chr116060292+20581085271148373
ENST00000375759SPENchr116203173+ENST00000375793PLEKHM2chr116060292+20581085271148373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375759ENST00000375799SPENchr116174645+PLEKHM2chr116053687+0.0400063130.95999366
ENST00000375759ENST00000375793SPENchr116174645+PLEKHM2chr116053687+0.0400063130.95999366
ENST00000375759ENST00000375799SPENchr116203173+PLEKHM2chr116058384+0.0324057680.96759415
ENST00000375759ENST00000375793SPENchr116203173+PLEKHM2chr116058384+0.0324057680.96759415
ENST00000375759ENST00000375799SPENchr116203173+PLEKHM2chr116060292+0.0124277470.9875723
ENST00000375759ENST00000375793SPENchr116203173+PLEKHM2chr116060292+0.0124277470.9875723

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Fusion Genomic Features for SPEN-PLEKHM2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SPENchr116174645+PLEKHM2chr116042731+1.46E-070.9999999
SPENchr116203173+PLEKHM2chr116058383+5.34E-081
SPENchr116203173+PLEKHM2chr116060291+5.19E-101
SPENchr116174645+PLEKHM2chr116042731+1.46E-070.9999999
SPENchr116203173+PLEKHM2chr116058383+5.34E-081
SPENchr116203173+PLEKHM2chr116060291+5.19E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPEN-PLEKHM2


check button Go to

FGviewer for the breakpoints of chr1:16174645-chr1:16053687

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315125_277293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315125_277293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3156_81293.66666666666673665.0DomainRRM 1
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3156_81293.66666666666673665.0DomainRRM 1
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020317_32001020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020323_32601020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020506_51101020.0Compositional biasNote=Poly-Gly
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020593_59601020.0Compositional biasNote=Poly-Leu
TgenePLEKHM2chr1:16174645chr1:16053687ENST0000037579902036_15801020.0DomainRUN
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020771_87301020.0DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151170_119127.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151408_142827.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151496_152927.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151592_161227.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151928_194427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115688_71527.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115977_100427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151170_1191293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151408_1428293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151496_1529293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151592_1612293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151928_1944293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315688_715293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315977_1004293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151170_1191293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151408_1428293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151496_1529293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151592_1612293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151928_1944293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315688_715293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315977_1004293.66666666666673665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115125_27727.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115240_32527.6666666666666683665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1152428_252027.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1153220_348227.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115616_81027.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115624_69727.6666666666666683665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315240_325293.66666666666673665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3152428_2520293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3153220_3482293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315616_810293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315624_697293.66666666666673665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315240_325293.66666666666673665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3152428_2520293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3153220_3482293.66666666666673665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315616_810293.66666666666673665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315624_697293.66666666666673665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1151_57327.6666666666666683665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3151_573293.66666666666673665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3151_573293.66666666666673665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1152201_270727.6666666666666683665.0DomainNote=RID
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115335_41527.6666666666666683665.0DomainRRM 2
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1153498_366427.6666666666666683665.0DomainSPOC
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115438_51327.6666666666666683665.0DomainRRM 3
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+115517_58927.6666666666666683665.0DomainRRM 4
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1156_8127.6666666666666683665.0DomainRRM 1
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3152201_2707293.66666666666673665.0DomainNote=RID
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315335_415293.66666666666673665.0DomainRRM 2
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3153498_3664293.66666666666673665.0DomainSPOC
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315438_513293.66666666666673665.0DomainRRM 3
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+315517_589293.66666666666673665.0DomainRRM 4
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3152201_2707293.66666666666673665.0DomainNote=RID
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315335_415293.66666666666673665.0DomainRRM 2
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3153498_3664293.66666666666673665.0DomainSPOC
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315438_513293.66666666666673665.0DomainRRM 3
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+315517_589293.66666666666673665.0DomainRRM 4
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520317_320821.66666666666661020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520323_326821.66666666666661020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520506_511821.66666666666661020.0Compositional biasNote=Poly-Gly
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520593_596821.66666666666661020.0Compositional biasNote=Poly-Leu
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820317_320974.01020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820323_326974.01020.0Compositional biasNote=Poly-Lys
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820506_511974.01020.0Compositional biasNote=Poly-Gly
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820593_596974.01020.0Compositional biasNote=Poly-Leu
TgenePLEKHM2chr1:16203173chr1:16058384ENST00000375799152036_158821.66666666666661020.0DomainRUN
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520771_873821.66666666666661020.0DomainPH
TgenePLEKHM2chr1:16203173chr1:16060292ENST00000375799182036_158974.01020.0DomainRUN
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820771_873974.01020.0DomainPH


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Fusion Gene Sequence for SPEN-PLEKHM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000375759_ENST00000375799_TCGA-GM-A2DH-01A_SPEN_chr1_16174645_+_PLEKHM2_chr1_16053687_length(transcript)=3062nt_BP=287nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGAGGAGGGAGAGGGGCCGAGCAGCACCACGGAGAGCAGCGAGCGCTCCGAGCCGGGCCTGCTGATCCCTGAGAT
GAAGGACACCTCCATGGAGCGCTTGGGGCAGCCCCTGAGCAAGGTTATCGACCAGCTCAACGGGCAGCTGGACCCCAGCACCTGGTGCTC
CCGTGCTGAGCCCCCAGACCAGTCCTTTCGGACCGGCTCTCCCGGGGATGCCCCGGAGAGGCCGCCGCTTTGCGACTTTAGTGAGGGGCT
TTCAGCCCCAATGGACTTCTACCGCTTTACCGTCGAGAGTCCAAGCACTGTTACATCAGGTGGCGGCCACCATGACCCTGCAGGGCTTGG
CCAACCGCTGCATGTTCCTAGTAGCCCTGAGGCTGCTGGCCAAGAAGAAGAGGGAGGAGGAGGAGAGGGACAGACGCCTCGGCCCCTAGA
GGATACCACGAGGGAGGCTCAGGAGCTGGAGGCCCAGCTGTCCCTGGTCAGGGAGGGGCCTGTGTCTGAGCCAGAGCCTGGGACCCAGGA
GGTTCTCTGCCAGCTCAAGCGAGACCAGCCCAGCCCGTGTCTGAGTAGCGCTGAGGATTCTGGGGTGGATGAGGGACAGGGGAGCCCTTC
GGAGATGGTCCATTCCTCGGAGTTCAGAGTAGACAACAATCACCTGCTCCTGCTCATGATCCACGTGTTCCGAGAAAACGAAGAGCAGCT
GTTCAAAATGATCCGGATGAGCACCGGGCACATGGAGGGCAACCTGCAGCTGCTGTACGTGCTGCTCACAGACTGCTATGTCTACCTGCT
CCGGAAAGGGGCCACAGAGAAGCCATACCTGGTGGAAGAGGCCGTTTCTTACAATGAACTTGACTATGTGTCGGTTGGCCTTGACCAGCA
GACGGTGAAGCTGGTGTGCACCAACCGCAGGAAGCAGTTTCTGCTGGACACGGCTGATGTGGCGCTGGCTGAGTTCTTTTTGGCTTCTTT
GAAGTCAGCCATGATCAAAGGCTGTCGAGAACCTCCCTACCCCAGCATCCTGACGGATGCCACCATGGAGAAGCTGGCACTGGCCAAATT
TGTGGCCCAAGAATCGAAGTGTGAGGCATCTGCTGTCACCGTGCGCTTCTACGGCCTTGTGCACTGGGAGGACCCCACAGACGAGTCCCT
GGGCCCCACGCCCTGCCACTGCTCACCCCCCGAGGGCACCATCACCAAAGAAGGCATGCTGCACTACAAGGCGGGCACCTCCTACCTGGG
CAAGGAACACTGGAAGACGTGCTTCGTGGTGCTCAGCAACGGGATCCTCTACCAGTACCCGGACCGCACCGACGTCATCCCTCTGCTCTC
GGTGAACATGGGGGGGGAGCAGTGCGGTGGCTGCCGGAGAGCCAACACCACGGATCGGCCCCACGCCTTCCAGGTCATTCTCTCCGACCG
GCCCTGCCTGGAGCTAAGTGCCGAGAGCGAGGCCGAGATGGCCGAGTGGATGCAGCATCTCTGCCAGGCTGTGTCCAAAGGGGTCATCCC
CCAGGGCGTAGCTCCCAGCCCCTGCATACCCTGCTGCCTGGTCCTCACGGATGACCGCCTCTTTACGTGCCATGAGGATTGCCAGACCAG
CTTCTTCCGCTCTTTGGGCACAGCCAAGCTGGGCGACATCAGCGCCGTCTCCACCGAGCCGGGCAAGGAGTACTGCGTCTTGGAGTTCTC
CCAGGACAGCCAGCAGCTCCTCCCGCCCTGGGTCATCTACCTGAGCTGCACTTCTGAACTGGACCGATTGCTGTCTGCACTGAACTCTGG
GTGGAAAACCATCTATCAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCAT
CCACAGCGCCTGGCAGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTG
GTGGGCAGGAAAGGAAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTG
GGCGGCAGAACCACCGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCC
GACAGGTAGCGAATGGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCA
GTCTGCAGAATTTCTGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTC
TCCTGGGTTGGGGGCTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGG
GGTGTCTGCGCATGTTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCT
GGCTGCCAGGAGGCTCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTG
GATGGGGGGCTTGGAGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCC
TTCCCTAGAGTTTCGTCAAGAGCCTCCTGGGGAAGGGGTCAGGTGGTTTGGGTTTTGTTTTTTAAAATAAAATAGACATGTTATATTGCC

>In-frame_ENST00000375759_ENST00000375799_TCGA-GM-A2DH-01A_SPEN_chr1_16174645_+_PLEKHM2_chr1_16053687_length(amino acids)=627AA_start in transcript=343_stop in transcript=2226
MLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHH
DPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDE
GQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVS
VGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWED
PTDESLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHAFQ
VILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEY

--------------------------------------------------------------
>In-frame_ENST00000375759_ENST00000375793_TCGA-GM-A2DH-01A_SPEN_chr1_16174645_+_PLEKHM2_chr1_16053687_length(transcript)=3062nt_BP=287nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGAGGAGGGAGAGGGGCCGAGCAGCACCACGGAGAGCAGCGAGCGCTCCGAGCCGGGCCTGCTGATCCCTGAGAT
GAAGGACACCTCCATGGAGCGCTTGGGGCAGCCCCTGAGCAAGGTTATCGACCAGCTCAACGGGCAGCTGGACCCCAGCACCTGGTGCTC
CCGTGCTGAGCCCCCAGACCAGTCCTTTCGGACCGGCTCTCCCGGGGATGCCCCGGAGAGGCCGCCGCTTTGCGACTTTAGTGAGGGGCT
TTCAGCCCCAATGGACTTCTACCGCTTTACCGTCGAGAGTCCAAGCACTGTTACATCAGGTGGCGGCCACCATGACCCTGCAGGGCTTGG
CCAACCGCTGCATGTTCCTAGTAGCCCTGAGGCTGCTGGCCAAGAAGAAGAGGGAGGAGGAGGAGAGGGACAGACGCCTCGGCCCCTAGA
GGATACCACGAGGGAGGCTCAGGAGCTGGAGGCCCAGCTGTCCCTGGTCAGGGAGGGGCCTGTGTCTGAGCCAGAGCCTGGGACCCAGGA
GGTTCTCTGCCAGCTCAAGCGAGACCAGCCCAGCCCGTGTCTGAGTAGCGCTGAGGATTCTGGGGTGGATGAGGGACAGGGGAGCCCTTC
GGAGATGGTCCATTCCTCGGAGTTCAGAGTAGACAACAATCACCTGCTCCTGCTCATGATCCACGTGTTCCGAGAAAACGAAGAGCAGCT
GTTCAAAATGATCCGGATGAGCACCGGGCACATGGAGGGCAACCTGCAGCTGCTGTACGTGCTGCTCACAGACTGCTATGTCTACCTGCT
CCGGAAAGGGGCCACAGAGAAGCCATACCTGGTGGAAGAGGCCGTTTCTTACAATGAACTTGACTATGTGTCGGTTGGCCTTGACCAGCA
GACGGTGAAGCTGGTGTGCACCAACCGCAGGAAGCAGTTTCTGCTGGACACGGCTGATGTGGCGCTGGCTGAGTTCTTTTTGGCTTCTTT
GAAGTCAGCCATGATCAAAGGCTGTCGAGAACCTCCCTACCCCAGCATCCTGACGGATGCCACCATGGAGAAGCTGGCACTGGCCAAATT
TGTGGCCCAAGAATCGAAGTGTGAGGCATCTGCTGTCACCGTGCGCTTCTACGGCCTTGTGCACTGGGAGGACCCCACAGACGAGTCCCT
GGGCCCCACGCCCTGCCACTGCTCACCCCCCGAGGGCACCATCACCAAAGAAGGCATGCTGCACTACAAGGCGGGCACCTCCTACCTGGG
CAAGGAACACTGGAAGACGTGCTTCGTGGTGCTCAGCAACGGGATCCTCTACCAGTACCCGGACCGCACCGACGTCATCCCTCTGCTCTC
GGTGAACATGGGGGGGGAGCAGTGCGGTGGCTGCCGGAGAGCCAACACCACGGATCGGCCCCACGCCTTCCAGGTCATTCTCTCCGACCG
GCCCTGCCTGGAGCTAAGTGCCGAGAGCGAGGCCGAGATGGCCGAGTGGATGCAGCATCTCTGCCAGGCTGTGTCCAAAGGGGTCATCCC
CCAGGGCGTAGCTCCCAGCCCCTGCATACCCTGCTGCCTGGTCCTCACGGATGACCGCCTCTTTACGTGCCATGAGGATTGCCAGACCAG
CTTCTTCCGCTCTTTGGGCACAGCCAAGCTGGGCGACATCAGCGCCGTCTCCACCGAGCCGGGCAAGGAGTACTGCGTCTTGGAGTTCTC
CCAGGACAGCCAGCAGCTCCTCCCGCCCTGGGTCATCTACCTGAGCTGCACTTCTGAACTGGACCGATTGCTGTCTGCACTGAACTCTGG
GTGGAAAACCATCTATCAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCAT
CCACAGCGCCTGGCAGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTG
GTGGGCAGGAAAGGAAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTG
GGCGGCAGAACCACCGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCC
GACAGGTAGCGAATGGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCA
GTCTGCAGAATTTCTGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTC
TCCTGGGTTGGGGGCTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGG
GGTGTCTGCGCATGTTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCT
GGCTGCCAGGAGGCTCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTG
GATGGGGGGCTTGGAGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCC
TTCCCTAGAGTTTCGTCAAGAGCCTCCTGGGGAAGGGGTCAGGTGGTTTGGGTTTTGTTTTTTAAAATAAAATAGACATGTTATATTGCC

>In-frame_ENST00000375759_ENST00000375793_TCGA-GM-A2DH-01A_SPEN_chr1_16174645_+_PLEKHM2_chr1_16053687_length(amino acids)=627AA_start in transcript=343_stop in transcript=2226
MLIPEMKDTSMERLGQPLSKVIDQLNGQLDPSTWCSRAEPPDQSFRTGSPGDAPERPPLCDFSEGLSAPMDFYRFTVESPSTVTSGGGHH
DPAGLGQPLHVPSSPEAAGQEEEGGGGEGQTPRPLEDTTREAQELEAQLSLVREGPVSEPEPGTQEVLCQLKRDQPSPCLSSAEDSGVDE
GQGSPSEMVHSSEFRVDNNHLLLLMIHVFRENEEQLFKMIRMSTGHMEGNLQLLYVLLTDCYVYLLRKGATEKPYLVEEAVSYNELDYVS
VGLDQQTVKLVCTNRRKQFLLDTADVALAEFFLASLKSAMIKGCREPPYPSILTDATMEKLALAKFVAQESKCEASAVTVRFYGLVHWED
PTDESLGPTPCHCSPPEGTITKEGMLHYKAGTSYLGKEHWKTCFVVLSNGILYQYPDRTDVIPLLSVNMGGEQCGGCRRANTTDRPHAFQ
VILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLGDISAVSTEPGKEY

--------------------------------------------------------------
>In-frame_ENST00000375759_ENST00000375799_TCGA-23-1111-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16058384_length(transcript)=2515nt_BP=1085nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGATATGGCCGCGTGGAAAGTGTCAAAATTCTTCCCAAGAGGGGATCTGAAGGAGGAGTGGCTGCCTTTGTGGAT
TTTGTGGACATCAAAAGTGCACAGAAAGCTCACAACTCGGTCAACAAAATGGGTGACAGAGACCTACGCACGGATTATAATGAACCAGGC
ACCATCCCGAGTGCTGCTCGGGGATTGGATGATACAGTTTCCATAGCATCTCGTAGTAGAGAGGTTTCTGGGTTCAGAGGAGGTGGTGGA
GGGCCTGCTTATGGTCCCCCACCGTCACTTCATGCACGAGAAGGACGTTATGAGCGGAGACTTGATGGGGCTTCAGATAACAGGGAGCGT
GCTTATGAACATAGTGCCTATGGACACCATGAACGGGGGACGGGAGGATTTGATCGGACAAGACATTACGATCAGGATTACTATAGAGAT
CCTCGAGAGCGGACTTTACAACATGGGCTCTATTACGCTTCTCGGAGTCGAAGTCCAAATCGCTTTGATGCTCATGACCCCCGATATGAA
CCTAGGGCTCGCGAGCAGTTTACACTGCCCAGTGTGGTACACAGGGATATCTACAGGGATGATATTACCCGGGAGGTACGAGGCAGAAGG
CCAGAGCGGAATTACCAGCACAGCAGGAGTCGGTCACCACATTCATCCCAGTCTAGAAATCAGTCTCCTCAGAGACTGGCTAGCCAAGCA
TCTAGACCCACAAGGTCCCCTAGCGGCAGCGGCTCTAGAAGTAGATCCTCCAGTAGTGATTCAATCAGCAGCAGCAGTAGTACCAGCAGT
GACAGGGGGGAGCAGTGCGGTGGCTGCCGGAGAGCCAACACCACGGATCGGCCCCACGCCTTCCAGGTCATTCTCTCCGACCGGCCCTGC
CTGGAGCTAAGTGCCGAGAGCGAGGCCGAGATGGCCGAGTGGATGCAGCATCTCTGCCAGGCTGTGTCCAAAGGGGTCATCCCCCAGGGC
GTAGCTCCCAGCCCCTGCATACCCTGCTGCCTGGTCCTCACGGATGACCGCCTCTTTACGTGCCATGAGGATTGCCAGACCAGCTTCTTC
CGCTCTTTGGGCACAGCCAAGCTGGGCGACATCAGCGCCGTCTCCACCGAGCCGGGCAAGGAGTACTGCGTCTTGGAGTTCTCCCAGGAC
AGCCAGCAGCTCCTCCCGCCCTGGGTCATCTACCTGAGCTGCACTTCTGAACTGGACCGATTGCTGTCTGCACTGAACTCTGGGTGGAAA
ACCATCTATCAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCATCCACAGC
GCCTGGCAGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTGGTGGGCA
GGAAAGGAAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTGGGCGGCA
GAACCACCGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCCGACAGGT
AGCGAATGGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCAGTCTGCA
GAATTTCTGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTCTCCTGGG
TTGGGGGCTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGGGGTGTCT
GCGCATGTTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCTGGCTGCC
AGGAGGCTCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTGGATGGGG
GGCTTGGAGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCCTTCCCTA

>In-frame_ENST00000375759_ENST00000375799_TCGA-23-1111-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16058384_length(amino acids)=550AA_start in transcript=27_stop in transcript=1679
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRYGR
VESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPS
LHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTL
PSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDRGEQCGGC
RRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLG
DISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLC

--------------------------------------------------------------
>In-frame_ENST00000375759_ENST00000375793_TCGA-23-1111-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16058384_length(transcript)=2515nt_BP=1085nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGATATGGCCGCGTGGAAAGTGTCAAAATTCTTCCCAAGAGGGGATCTGAAGGAGGAGTGGCTGCCTTTGTGGAT
TTTGTGGACATCAAAAGTGCACAGAAAGCTCACAACTCGGTCAACAAAATGGGTGACAGAGACCTACGCACGGATTATAATGAACCAGGC
ACCATCCCGAGTGCTGCTCGGGGATTGGATGATACAGTTTCCATAGCATCTCGTAGTAGAGAGGTTTCTGGGTTCAGAGGAGGTGGTGGA
GGGCCTGCTTATGGTCCCCCACCGTCACTTCATGCACGAGAAGGACGTTATGAGCGGAGACTTGATGGGGCTTCAGATAACAGGGAGCGT
GCTTATGAACATAGTGCCTATGGACACCATGAACGGGGGACGGGAGGATTTGATCGGACAAGACATTACGATCAGGATTACTATAGAGAT
CCTCGAGAGCGGACTTTACAACATGGGCTCTATTACGCTTCTCGGAGTCGAAGTCCAAATCGCTTTGATGCTCATGACCCCCGATATGAA
CCTAGGGCTCGCGAGCAGTTTACACTGCCCAGTGTGGTACACAGGGATATCTACAGGGATGATATTACCCGGGAGGTACGAGGCAGAAGG
CCAGAGCGGAATTACCAGCACAGCAGGAGTCGGTCACCACATTCATCCCAGTCTAGAAATCAGTCTCCTCAGAGACTGGCTAGCCAAGCA
TCTAGACCCACAAGGTCCCCTAGCGGCAGCGGCTCTAGAAGTAGATCCTCCAGTAGTGATTCAATCAGCAGCAGCAGTAGTACCAGCAGT
GACAGGGGGGAGCAGTGCGGTGGCTGCCGGAGAGCCAACACCACGGATCGGCCCCACGCCTTCCAGGTCATTCTCTCCGACCGGCCCTGC
CTGGAGCTAAGTGCCGAGAGCGAGGCCGAGATGGCCGAGTGGATGCAGCATCTCTGCCAGGCTGTGTCCAAAGGGGTCATCCCCCAGGGC
GTAGCTCCCAGCCCCTGCATACCCTGCTGCCTGGTCCTCACGGATGACCGCCTCTTTACGTGCCATGAGGATTGCCAGACCAGCTTCTTC
CGCTCTTTGGGCACAGCCAAGCTGGGCGACATCAGCGCCGTCTCCACCGAGCCGGGCAAGGAGTACTGCGTCTTGGAGTTCTCCCAGGAC
AGCCAGCAGCTCCTCCCGCCCTGGGTCATCTACCTGAGCTGCACTTCTGAACTGGACCGATTGCTGTCTGCACTGAACTCTGGGTGGAAA
ACCATCTATCAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCATCCACAGC
GCCTGGCAGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTGGTGGGCA
GGAAAGGAAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTGGGCGGCA
GAACCACCGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCCGACAGGT
AGCGAATGGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCAGTCTGCA
GAATTTCTGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTCTCCTGGG
TTGGGGGCTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGGGGTGTCT
GCGCATGTTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCTGGCTGCC
AGGAGGCTCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTGGATGGGG
GGCTTGGAGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCCTTCCCTA

>In-frame_ENST00000375759_ENST00000375793_TCGA-23-1111-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16058384_length(amino acids)=550AA_start in transcript=27_stop in transcript=1679
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRYGR
VESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPS
LHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTL
PSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDRGEQCGGC
RRANTTDRPHAFQVILSDRPCLELSAESEAEMAEWMQHLCQAVSKGVIPQGVAPSPCIPCCLVLTDDRLFTCHEDCQTSFFRSLGTAKLG
DISAVSTEPGKEYCVLEFSQDSQQLLPPWVIYLSCTSELDRLLSALNSGWKTIYQVDLPHTAIQEASNKKKFEDALSLIHSAWQRSDSLC

--------------------------------------------------------------
>In-frame_ENST00000375759_ENST00000375799_TCGA-DX-AB2P-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16060292_length(transcript)=2058nt_BP=1085nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGATATGGCCGCGTGGAAAGTGTCAAAATTCTTCCCAAGAGGGGATCTGAAGGAGGAGTGGCTGCCTTTGTGGAT
TTTGTGGACATCAAAAGTGCACAGAAAGCTCACAACTCGGTCAACAAAATGGGTGACAGAGACCTACGCACGGATTATAATGAACCAGGC
ACCATCCCGAGTGCTGCTCGGGGATTGGATGATACAGTTTCCATAGCATCTCGTAGTAGAGAGGTTTCTGGGTTCAGAGGAGGTGGTGGA
GGGCCTGCTTATGGTCCCCCACCGTCACTTCATGCACGAGAAGGACGTTATGAGCGGAGACTTGATGGGGCTTCAGATAACAGGGAGCGT
GCTTATGAACATAGTGCCTATGGACACCATGAACGGGGGACGGGAGGATTTGATCGGACAAGACATTACGATCAGGATTACTATAGAGAT
CCTCGAGAGCGGACTTTACAACATGGGCTCTATTACGCTTCTCGGAGTCGAAGTCCAAATCGCTTTGATGCTCATGACCCCCGATATGAA
CCTAGGGCTCGCGAGCAGTTTACACTGCCCAGTGTGGTACACAGGGATATCTACAGGGATGATATTACCCGGGAGGTACGAGGCAGAAGG
CCAGAGCGGAATTACCAGCACAGCAGGAGTCGGTCACCACATTCATCCCAGTCTAGAAATCAGTCTCCTCAGAGACTGGCTAGCCAAGCA
TCTAGACCCACAAGGTCCCCTAGCGGCAGCGGCTCTAGAAGTAGATCCTCCAGTAGTGATTCAATCAGCAGCAGCAGTAGTACCAGCAGT
GACAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCATCCACAGCGCCTGGC
AGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTGGTGGGCAGGAAAGG
AAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTGGGCGGCAGAACCAC
CGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCCGACAGGTAGCGAAT
GGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCAGTCTGCAGAATTTC
TGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTCTCCTGGGTTGGGGG
CTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGGGGTGTCTGCGCATG
TTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCTGGCTGCCAGGAGGC
TCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTGGATGGGGGGCTTGG
AGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCCTTCCCTAGAGTTTC

>In-frame_ENST00000375759_ENST00000375799_TCGA-DX-AB2P-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16060292_length(amino acids)=373AA_start in transcript=27_stop in transcript=1148
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRYGR
VESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPS
LHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTL
PSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDRWTSPTRR

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>In-frame_ENST00000375759_ENST00000375793_TCGA-DX-AB2P-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16060292_length(transcript)=2058nt_BP=1085nt
TGAGCTGCGAGGCCCGAGAGTCAGAACCTGGGGGAGAGGGATGGTCTCTGCACGGGGGGGAGCCGGAGGAGCCGCCGCCGCTGCCGACGC
CACCGCCGCAGCCGCCGCCGCCGCCGCCCCGGCACCCGCCTCCCGGCGCTGACGGTCTCGTACGAAGCCGGCGAGGGGGAGCCAGCAGCG
GCGGTCGCCGGCACGCCGCCCAGCATGGTCCGGGAAACCAGGCATCTCTGGGTGGGCAACTTACCCGAGAACGTGCGGGAAGAGAAGATC
ATCGAGCATTTCAAACGATATGGCCGCGTGGAAAGTGTCAAAATTCTTCCCAAGAGGGGATCTGAAGGAGGAGTGGCTGCCTTTGTGGAT
TTTGTGGACATCAAAAGTGCACAGAAAGCTCACAACTCGGTCAACAAAATGGGTGACAGAGACCTACGCACGGATTATAATGAACCAGGC
ACCATCCCGAGTGCTGCTCGGGGATTGGATGATACAGTTTCCATAGCATCTCGTAGTAGAGAGGTTTCTGGGTTCAGAGGAGGTGGTGGA
GGGCCTGCTTATGGTCCCCCACCGTCACTTCATGCACGAGAAGGACGTTATGAGCGGAGACTTGATGGGGCTTCAGATAACAGGGAGCGT
GCTTATGAACATAGTGCCTATGGACACCATGAACGGGGGACGGGAGGATTTGATCGGACAAGACATTACGATCAGGATTACTATAGAGAT
CCTCGAGAGCGGACTTTACAACATGGGCTCTATTACGCTTCTCGGAGTCGAAGTCCAAATCGCTTTGATGCTCATGACCCCCGATATGAA
CCTAGGGCTCGCGAGCAGTTTACACTGCCCAGTGTGGTACACAGGGATATCTACAGGGATGATATTACCCGGGAGGTACGAGGCAGAAGG
CCAGAGCGGAATTACCAGCACAGCAGGAGTCGGTCACCACATTCATCCCAGTCTAGAAATCAGTCTCCTCAGAGACTGGCTAGCCAAGCA
TCTAGACCCACAAGGTCCCCTAGCGGCAGCGGCTCTAGAAGTAGATCCTCCAGTAGTGATTCAATCAGCAGCAGCAGTAGTACCAGCAGT
GACAGGTGGACCTCCCCCACACGGCGATCCAGGAAGCCTCCAACAAGAAGAAATTCGAGGATGCCTTGAGCCTCATCCACAGCGCCTGGC
AGCGGAGCGACAGTCTCTGCCGCGGCCGAGCCTCCCGAGACCCCTGGTGCTGAGGCAGAGCTGGTTGGCGTCCCTGGTGGGCAGGAAAGG
AAGGCACGCCAGCCGGCAGGCACACTGTCACGGCTGTTGTCATGCTGTCGGGAGCCTACAGTCCACCCCTGCCCTGGGCGGCAGAACCAC
CGAGTGTGGCTTAAGACAGGGTCCCTCCACTCCAGGGATCCAGATCAGGTGCCCGGCACCCCTGGGCATCCTGCCCGACAGGTAGCGAAT
GGAGGTCGCTGGGGGCAGAGGGTCCGAGCCCTGTGGGCTCTGCGGATGCACGCCCTCCTCCCGGGCCTCCGCCTCAGTCTGCAGAATTTC
TGCCGAGTGGCACCGAGAACACCATCCATCTAAGGACGAACAAAAGAACCAGGAGGGCGGGACCCCCCTCTTCCTCTCCTGGGTTGGGGG
CTGGGGCCCTGAGTGCCCAGCCATCCTTGTTCGTGTTTGAACACTCTCCTGGCCACGTGGGGAAGCGGGAACACGGGGTGTCTGCGCATG
TTTCCTCCTCCTAGCTCCATCACTGCGCACACAGCTGCCTGCCTCGCCAGATGCAGGGGGGCGGGCAGCCCTCCCTGGCTGCCAGGAGGC
TCTGCATGCCCACAGTCCTGCCCTGCCTGTCCCCTCAACCCGGCAGTGCCTGTAGCACCGAGGAGCAAAGGGGGTGGATGGGGGGCTTGG
AGAAGGGCGGAGCCCACCAGCCTGGCATCCATGTTGACATCTTCTGACTGTCCCCTGCTTGGCTGGAGCCAGGCCCTTCCCTAGAGTTTC

>In-frame_ENST00000375759_ENST00000375793_TCGA-DX-AB2P-01A_SPEN_chr1_16203173_+_PLEKHM2_chr1_16060292_length(amino acids)=373AA_start in transcript=27_stop in transcript=1148
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRYGR
VESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDDTVSIASRSREVSGFRGGGGGPAYGPPPS
LHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGGFDRTRHYDQDYYRDPRERTLQHGLYYASRSRSPNRFDAHDPRYEPRAREQFTL
PSVVHRDIYRDDITREVRGRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSTSSDRWTSPTRR

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Fusion Gene PPI Analysis for SPEN-PLEKHM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgenePLEKHM2chr1:16174645chr1:16053687ENST000003757990201_31001020.0KIF5B
TgenePLEKHM2chr1:16174645chr1:16053687ENST00000375799020762_88501020.0sifA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1152130_246427.6666666666666683665.0MSX2
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3152130_2464293.66666666666673665.0MSX2
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3152130_2464293.66666666666673665.0MSX2
HgeneSPENchr1:16174645chr1:16053687ENST00000375759+1152709_287027.6666666666666683665.0RBPSUH
HgeneSPENchr1:16203173chr1:16058384ENST00000375759+3152709_2870293.66666666666673665.0RBPSUH
HgeneSPENchr1:16203173chr1:16060292ENST00000375759+3152709_2870293.66666666666673665.0RBPSUH
TgenePLEKHM2chr1:16203173chr1:16058384ENST0000037579915201_310821.66666666666661020.0KIF5B
TgenePLEKHM2chr1:16203173chr1:16060292ENST0000037579918201_310974.01020.0KIF5B
TgenePLEKHM2chr1:16203173chr1:16058384ENST000003757991520762_885821.66666666666661020.0sifA
TgenePLEKHM2chr1:16203173chr1:16060292ENST000003757991820762_885974.01020.0sifA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SPEN-PLEKHM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SPEN-PLEKHM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPENC0033578Prostatic Neoplasms1CTD_human
HgeneSPENC0376358Malignant neoplasm of prostate1CTD_human
TgenePLEKHM2C1960469Left ventricular noncompaction1ORPHANET